Mathias Brochhausen
Meiu Wong
Darrell R. Abernethy
Zuoshuang "Allen" Xiang
Rebecca Racz
The Ontology of Adverse Eventsy (OAE) is a biomedical ontology in the domain of adverse events. OAE aims to standardize adverse event annotation, integrate various adverse event data, and support computer-assisted reasoning. OAE is a community-based ontology. Its development follows the OBO Foundry principles. Vaccine adverse events have been used as an initial testing use case. OAE also studies adverse events associated with the administration of drug and nutritional products, the operation of surgeries, and the usage of medical devices, etc.
OAE: Ontology of Adverse Events
Product version
Sydni Joubran
"Asiyah" Yu Lin
Luca Toldo
Kelly Yang
Yongqun "Oliver" He (YH)
OWL-DL
Kevin Mo
Izabela Birsanescu
Shelley Zhang
Jiangan Xie
Vision Release; 1.1.333
Sydni Joubran
Liwei Wang
Elizabeth Blair
Desikan Jagannathan
Edison Ong
Abra Guo
Qingping Liu
Keith Burkhart
An ontology for the annotation of the adverse event domain.
2017-01-18
Sirarat Sarntivijai
Barry Smith
BFO OWL specification label
BFO CLIF specification label
editor preferred term
example of usage
has curation status
definition
editor note
definition editor
term editor
alternative term
definition source
curator note
imported from
elucidation
has associated axiom(nl)
has associated axiom(fol)
has axiom label
YH, JX
a chinese translation represents a chinese translation of the existing term.
Chinese translation
The AE 'cough AE' has the 'label of AE outcome' of 'cough'; 'infection AE' has the 'label of AE outcom' of 'infection'.
an annotation property that represents the label of an adverse event
Yongqun Oliver He, Jiangan Hardy Xie
label of adverse event outcome
adverse event outcome
has_meddra_id
has_alternative_id
database_cross_reference
has_exact_synonym
has_narrow_synonym
has_related_synonym
in_subset
label
a preceded_by relation that indicates that one process (e.g., an adverse event) is causally preceded by (induced by) another process (e.g., a medical intervention) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes.
Yongqun He
induced by
induced_by
the relation indicates that one process (e.g., a medical intervention) induces another process (e.g., an adverse event) and there is a causal relation between these two processes. This relation indicates the existence of a causal chain, meaning many processes may occur in between these two processes. This is an inverse relation of the term "induced_by".
YH, AG
induces
This is a tentative relation. We need to get this role from another ontology later. Oliver
-- BFO 2.0 has this role 'is role of':: http://purl.obolibrary.org/obo/BFO_0000081
Once we get BFO 2.0, we can replace with this role.
Oliver
role_of
An electrocardiogram qt prolonged AE is_evidence_of arrhythmia AE; arrhythmia AE is_evidence_of cardiomyopathy AE; fever AE is_evidence_of inflammation AE; fever AE is_evidence_of viral infection AE; plural effusion AE is_evidence_of cardiac disorder AE.
AE1 is_evidence_of AE2 if and only if: given an adverse event instance ae1 that instantiates class AE1 (e.g., electrocardiogram qt prolonged AE) and another adverse event instance ae2 that instantiates class AE2 (e.g., arrhythmia AE), both ae1 and ae2 are adverse events that are clinically observed after a medical intervention (at time t0) on the same patient. The presence of ae1 is supported by priori knowledge of medicine to imply the presence of ae2 with some probability P (P is NOT always 1, thus transitivity does not apply to is_evidence_of relation. AE1 is_evidence_of AE2 and AE2 is_evidence_of AE3 DOES NOT imply AE1 is_evidence_of AE3). The instance ae1 and ae2 are observed or detected at time t1 and t2, respectively. The biological onset time for ae1 or ae2 may occur before t1 or t2. The t1 and t2 can be the same time point or different time points.
This represents a relation between two adverse events AE1 and AE2. However, AE1 may be an evidence of another adverse event AE3, and a dfferent adverse event AE4 may also be an evidence of the same AE2.
SS, YH, YL
is evidence of
An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased.
an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality.
This is a shortcut relation of the following full version:
'has participant' some (participant 'has quality' )
in: process 'has participant' some (participant 'has quality' some quality)
Yongqun He
has participant quality
a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in.
Yongqun He
adverse event occurs in
A shortcut relation that represents the full path of ‘has participant’ some participant that ‘participates in’ some process.
Yongqun He
has participant undergoing
a specific 'preceded by' object property that has a domain of an adverse event.
Yongqun He
adverse event preceded by
a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event.
Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'.
YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device.
YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention.
YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action).
Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623.
YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper.
We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process.
The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740.
YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events.
YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'.
Yongqun He
AE
adverse reaction
WEB: http://en.wikipedia.org/wiki/Adverse_event
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068
The OAE official website is: http://www.oae-ontology.org/.
adverse event
medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury.
The act of intervening, interfering or interceding with the intent of modifying the outcome. In medicine, an intervention is usually undertaken to help treat or cure a condition. For example, "Acupuncture as a therapeutic intervention is widely practiced in the United States,"
Reference:
http://www.medterms.com/script/main/art.asp?articlekey=34214 . Some interventions can be used for diagnosis.
YH
WEB: http://wiki.answers.com/Q/What_is_medical_intervention
medical intervention
an adverse event which is a causal adverse event, a pathological bodily process that is induced by a medical intervention.
YH: The term 'causal adverse event' has the same meaning as we previously defined as 'adverse event'. Reference: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper.
We made the name changing as a way to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention.
YH
adverse effect
He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper.
YH: the term "adverse effect" has the same meaning of "causal adverse event".
causal adverse event
an adverse event that occurs after a vaccination.
YH
vaccine adverse event
an adverse event that occurs after a drug administration
YH, JX
ADE
ADR
adverse drug reaction
drug adverse event
adverse drug event
an adverse event that is associated with the usage of a medical device.
YH
medical device adverse event
an adverse event that is associated with eating a medical food.
YH
medical food adverse event
an adverse event that is induced by consuming a nutritional product.
YH
nutritional product adverse event
an adverse event that is associated with consuming a dietary supplement.
YH
dietary supplement adverse event
an adverse event that is associated with consuming an infant formula.
YH
infant formula adverse event
a medical intervention where a patient is administered with a drug
YH
drug administration
a medical intervention that uses a medical device
YH
medical device usage for medical intervention
a medical intervention that uses a nutritional product
YH
consumption of nutritional product
nutritional product usage
a nutritional product usage that consumes a dietary supplement
YH
dietary supplement consumption
a nutritional product usage that consumes infant formula
YH
consumption of infant formula
a nutritional product usage that consumes medial food
YH
consumption of medical food
an imaging investigation result abnormal AE that is characterized by an abnormal X-ray
SS, YH, EB
10048065
X-ray result abnormal AE
an X-ray result abnormal AE that has an outcome of an abnormality in chest X-ray test
SS, YH
10008499
chest X-ray abnormal AE
a haematoma AE that has an outcome of contusion.
SS, YH
WEB: http://en.wikipedia.org/wiki/Bruise
10050584
Contusion is a type of relatively minor hematoma of tissue in which capillaries and sometimes venules are damaged by trauma, allowing blood to seep into the surrounding interstitial tissues.
contusion AE
a digestive system AE which has an outcome of dry throat, which is a sensation of dryness in the throat.
SS, YH
10013789
dry throat AE
a skin discoloration AE which has an outcome of flushing, a sudden reddening of the face, neck, or upper chest
SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003241.htm
脸红
10016825
flushing AE
CTCAE:E13771
HPO: HP_0001033
NCIt:C26775
SIDER: C0016382
a pain AE where the pain reachs an extreme level.
SS, YH, MW
10033425
pain in extremity AE
CTCAE: E12512
HPO: HP_0009763
NCIt: C78515
SIDER: C0030196
a respiratory system AE which has an outcome of postnasal drip, which occurs when excessive mucus is produced by the nasal Mucosa. The excess mucus accumulates in the throat or back of the nose.
SS, YH
PDN
UACS
Upper Airway Cough Syndrome
WEB: http://en.wikipedia.org/wiki/Post-nasal_drip
10036402
postnasal drip AE
CTCAE: E13514
NCIt: C78566
a syndrome AE that is subclassified as five defined entities which represent clinical circumstances in which both the heart and the kidney are involved in a bidirectional injury and dysfunction via a final common pathway of cell-to-cell death and accelerated apoptosis mediated by oxidative stress. Types 1 and 2 involve acute and chronic cardiovascular disease (CVD) scenarios leading to acute kidney injury or accelerated chronic kidney disease. Types 2 and 3 describe acute and chronic kidney disease leading primarily to heart failure, although it is possible that acute coronary syndromes, stroke, and arrhythmias could be CVD outcomes in these forms of CRS. Finally, CRS type 5 describes a simultaneous insult to both heart and kidneys, such as sepsis, where both organs are injured simultaneously.
SS, YH
CRS
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030731/
10068230
cardiorenal syndrome AE
A bursal disorder AE that has an outcome of the symptom of bursitis.
SS, YH
bursa inflammation
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001456/
bursitis AE
an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue.
YH, RR, JX
musculoskeletal and connective tissue disorder AE
WEB: http://www.cdc.gov/niosh/programs/msd/
10028395
A musculoskeletal disorder is an injury or disorder of the muscles, nerves, tendons, joints, cartilage, or supporting structures of the upper or lower limbs, neck, or lower back that are caused, precipitated, or exacerbated by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture
musculoskeletal or connective tissue AE
CTCAE: E13872
A statistical test can be used to accept or reject the hypothesis.
YH
a hypothesis about the causal relation between an adverse event and a medical intervention. This term can be used to hypothesize and evaluate the relation between a medical intervention (e.g., drug, vaccination) and case reports from an adverse event reporting system (e.g., VAERS).
CAE hypothesis
causal adverse event hypothesis
a musculoskeletal system AE which has an outcome of bursal disorder
YH
bursal disorder AE
a vaccine adverse event that is induced by an influenza vaccine.
YH: This term is just used as an example of vaccine induced adverse events. Specific vaccine-associated and vaccine-induced adverse events are now represented with the Ontology of Vaccine Adverse Events (OVAE).: http://www.violinet.org/ovae/.
YH
influenza vaccine-induced adverse event
an influenza vaccine adverse event that is induced by a killed influenza vaccine (KIV).
YH
KIV-induced adverse event
A KIV-induced AE that results in a GBS.
YH
VAERS statistical data analysis
There is little evidence to support a causal association between GBS and most vaccines. The evidence for a causal association is strongest for the swine influenza vaccine that was used in 1976-77. Studies of influenza vaccines used in subsequent years, however, have found small or no increased risk of GBS.
Reference: http://www.ncbi.nlm.nih.gov/pubmed?term=19388722.
KIV-induced GBS averse event in 1976-1977
a muscle pain AE that is induced by Afluria influenza vaccine administration
YH
WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf
Afluria-induced muscle ache AE
a behavior and neurological AE that has an outcome of fatigue, which is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities.
lethargy is sometimes reported as an extreme fatigue:
http://the-difference-between.com/lethargy/fatigue
they are sometimes regarded as synonyms:
https://www.nlm.nih.gov/medlineplus/ency/article/003088.htm
SS, YH, MW
lethargy AE
WEB: http://en.wikipedia.org/wiki/Fatigue_%28medical%29
10016256
10024264
fatigue AE
CTCAE: E11098 (fatigue); CTCAE: E12709 (lethargy)
HPO: HP_0003388
NCIt: C3036; NCIt: C78416
SIDER: C0015672
a microbiology and serology investigation result abnormal AE that has an outcome of CSF culture negative. The negative result means no bacteria, viruses, or fungi grew in the laboratory dish.
YH: The negative result is normal. It is not an AE.
SS, YH, EB
CSF culture negative AE
a lab test abnormal AE that has an outcome of an abnormal result in a blood cell lab test
SS, YH
blood cell lab test abnormal AE
an eosinophil percentage abnormal AE that has an outcome of increased eosinophil percentage
YH, EB
10052222
eosinophil percentage increased AE
a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by an obstruction of the blood supply to the heart
SS
WEB: http://www.ncbi.nlm.nih.gov/mesh/68009203
心肌梗塞
10028596
myocardial infarction AE
CTCAE: E10152
HPO: HP_0001658
NCIt: C27996
SIDER: C0027051
a neutrophil count abnormal AE that has an outcome of increased neutrophil count
YH
10029368
neutrophil count increased AE
HPO: HP_0011991
SIDER: NA
an adverse event that shows a complication that occurs after a medical procedure and is directly related to the precedure itself.
SS, YH
post-procedural AE
procedural disorder AE
procedure AE
procedural complication AE
an injury and procedural complication AE which has an outcome of injury
SS, YH
10022116
injury AE
an injury AE which has an outcome of head injury
SS, YH
10019196
head injury AE
a behavior and neurological AE that has an abnormal outcome in social behavior
SS, YH
social behavior AE
a social behavior AE that has an outcome of impaired work ability
SS, YH
impaired work ability AE
an allergy AE which has an outcome of injection-site allergic reaction
10022095
injection-site allergic reaction AE
a myelitis AE which has an outcome of myelitis transverse. Transverse myelitis (in Latin nomenclature: myelitis transversa) is a neurological disorder caused by an inflammatory process of the spinal cord, and can cause axonal demyelination.
SS, YH
WEB: http://en.wikipedia.org/wiki/Transverse_myelitis
10028527
myelitis transverse AE
a skin adverse even that has an outcome of warm skin
SS, YH
skin warm AE
Nystagmus AE is an eye AE that is a condition of involuntary eye movement, acquired in infancy or later in life, that may result in reduced or limited vision. Due to the involuntary movement of the eye, it is often called "dancing eyes".
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Nystagmus
10029864
nystagmus AE
CTCAE:E12748
NCIt:C3282
眼球震颤
a dermatitis AE that has an outcome of dermatitis bullous
SS, YH
bullous pemphigoid AE
10012441
Bullous pemphigoid is a skin disorder characterized by large blisters.
dermatitis bullous AE
HPO: HP_0011123
SIDER: C0085932
a skin adverse event that is characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling.
SS, YH, MW
hot flash AE
hot flashes AE
hot flush AE
10020407
hot flushes AE
CTCAE: E13781
HPO: HP_0008209
NCIt: C3109
SIDER: C0600142
a KIV-induced adverse event that has an outcome of Afluria-induced adverse event
YH
Afluria-induced adverse event
an adverse event that results in the outcome of a tumor.
mass AE
nodule AE
tumour AE
10026865
YH, RR
tumor AE
a respiratory system AE which has an outcome of wheezing, a high-pitched whistling sound made while breathing.
SS, YH, MW
WEB: http://www.mayoclinic.org/symptoms/wheezing/basics/definition/sym-20050764
10047924
wheezing AE
CTCAE:E13605
NCIt:C78718
a behavior and neurological AE that has an outcome of weight bearing difficulty
weight bearing difficulty is a behavior AE that results in difficulty in managing the amount of weight a patient puts on the leg on which surgery has been performed. In general, it is described as a percentage of the body weight, because each leg of a healthy person carries the full body weight when walking, in an alternating fashion.
SS, YH
WEB: http://en.wikipedia.org/wiki/Weight-bearing
weight bearing difficulty AE
A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment.
Yongqun He, Sirarat Sarntivijai, Mathias Brochhausen, William Hogan, Philip E. Empey
http://en.wikipedia.org/wiki/Contraindication
contraindication
a drug administration that uses incorrect drug dose
YH
incorrect drug dose administration
an Afluria-induced adverse event that has an outcome of Afluria-induced fever in child
YH
WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf
Afluria-induced fever AE in child
an Afluria-induced adverse event that has an outcome of Afluria-induced cough in child
YH
WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf
Afluria-induced cough AE in child
an Afluria-induced adverse event which has an outcome of Afluria-induced injection site pain
YH
WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf
Afluria-induced injection site pain AE
an Afluria-induced adverse event that has an outcome of Afluria-induced injection site redness
YH
WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf
Afluria-induced injection site redness AE
an Afluria-induced AE that has an outcome of Afluria-induced inject site swelling
YH
WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf
Afluria-induced inject site swelling AE
an Afluria-induced adverse event that has an outcome of Afluria-induced headache
YH
WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM220730.pdf
Afluria-induced headache AE
an adverse event that occurs systematically throughout the systemic circulation. This is different from local adverse event that is limited or a certain location.
YH, JX
systematic adverse event
URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction
systematic AE
A pregnancy, neonatal and perinatal AE that displays a disorder associated with pregnancy.
prenatal AE
WEB: https://en.wikipedia.org/wiki/Complications_of_pregnancy
WEB: https://en.wikipedia.org/wiki/Prenatal_diagnosis
YH, JX
pregnancy AE
a temporal interval that starts at the time a medical intervention occurs and ends at the time an adverse event outcome appears. This is the time = 'time instant of an adverse event outcome observed' - 'time instant of medical intervention'.
YH, XZ
adverse event incubation time
a procedure complication AE that occurs after a surgery.
YH
surgery adverse event
surgical procedure AE
The key difference between a surgery and a procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. Technically speaking, a surgery is a specific type of procedure. A procedure is a broad general term that refers to any series of pre-defined steps that should be followed to achieve a desired result. Therefore, a “surgical procedure” is synonymous with a “surgery.” See more: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm.
surgery AE
Surgery is a medical procedure that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance. The key difference between a surgery and a general procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery.
YH, SS
surgical procedure
WEB: http://en.wikipedia.org/wiki/Surgery
WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm
10042609
surgery
a sugery adverse event that has an outcome of pressure ulcer.
YH
surgery-induced bedsore AE
surgery-induced decubitus ulcer AE
surgery-induced pressure ulcer AE
an adverse event which occurs in a metabolism process (including anabolism and catabolism), endocrine system, or exocrine system.
SS, YH, JX
metabolism, endocrine, and exocrine system AE
10027433
metabolism, endocrine or exocrine system AE
MP: 0005266
an adverse event that occurs in clinical trial.
YH
clinical trial adverse event
a termporal instant that is the time when a medical intervention occurs.
YH
time instant of medical intervention
time at medical intervention
a temporal instant that is the time when an outcome of an adverse event (e.g., fever) is observed.
YH
time instant of an adverse event outcome observed
an influenza vaccine adverse event that is induced by a live attenuated influenza vaccine (LAIV).
YH
LAIV-induced adverse event
an LAIV-induced adverse event that is caused by the FluMist LAIV.
YH
WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf
FluMist-induced adverse event
a FluMist-induced adverse event that has an outcome of FluMist-induced runny nose
YH
FluMist-induced runny nose AE
a FluMist-induced AE that has an outcome of FluMist-induced nasal congestion
YH
FluMist-induced nasal congestion AE
a planned process that is specifically a test conducted in a clinical laboratory.
Rebecca Racz, Yongqun He
medical laboratory test
WEB: http://labmed.ascpjournals.org/content/40/2/105.full
clinical laboratory test
A FluMist-induced AE that has an outcome of sore throat
YH
WEB: http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM123743.pdf
FluMist-induced sore throat AE in adult
a tumore AE that results in the outcome of a benign tumor.
YH
benign tumor AE
a tumore AE that results in the outcome of a malignant tumor.
YH
malignant tumor AE
a sensory capability AE that resuls in an uncomfortable feeling.
YH
discomfort AE
HPO: HP_0010832
SIDER: C0234215
a reproductive system AE that occurs on the female side.
YH
10038604
female reproductive system AE
a reproductive system AE that occurs on the male side.
YH
male reproductive system AE
a cardiovascular disorder AE that has a cardiac disorder outcome.
SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/heart+disease Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23091623
10007541
10061024
cardiac disorder AE
HPO: HP_0001627
SIDER: C0018799
a cardiovascular disorder AE that has a vascular disorder outcome
10047065
vascular disorder AE
a skin adverse event that results in an inflammation of skin
SS, YH
10012431
dermatitis AE
HPO: HP_0011123
SIDER: C0011603
a drug adverse event that is induced by aspirin.
YH
WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm
aspirin-induced adverse event
an aspirin-induced adverse event that is induced by the aspirin drug Aspidrox.
Aspidrox-induced adverse event
an aspirin-induced adverse event that has an outcome of nausea
YH
WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm
aspirin-induced nausea AE
an aspirin-induced adverse event that has an outcome of vomiting
YH
WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm
aspirin-induced vomiting AE
an aspirin-induced adverse event that has an outcome of stomach pain
YH
WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm
aspirin-induced stomach pain AE
an aspirin-induced adverse event that has an outcome of heartburn
YH
WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm
aspirin-induced heartburn AE
an aspirin-induced adverse event that has an outcome of rash symptom.
YH
WEB: http://www.consumerreports.org/health/prescription-drugs/aspirin/while-taking.htm
aspirin-induced rash AE
a medical intervention that is used for therapeutic purpose
YH
therapeutic intervention
YH
a drug adverse event that is caused by a drug adiministration. Here a causal effect is established between the drug administration and the adverse event.
causal adverse drug event
a medical device adverse event that is induced by a medical device. There is a causal relation between the adverse event and the usage of a medical device.
YH
adverse event induced by medical device
an adverse event that is induced by a vaccination.
YH
vaccine-induced adverse event
a surgery adverse event that is caused by a surgery.
YH
surgery-induced adverse event
YH
a nutritional product adverse event that has a causal assocition with the usage of the nutritional product.
nutritional product-induced adverse event
influenza like illness AE is an adverse event that has an outcome of a medical diagnosis of possible influenza or other illness causing a set of common symptoms
SS, YH
acute respiratory infection, ARI, flu-like syndrome
WEB: http://en.wikipedia.org/wiki/Influenza-like_illness
10016791
influenza like illness AE
HPO: HP_0005376
MDR: 10022004
SIDER: C0521839
a prediction process that allows prediction of a causal adverse event induced by a medical intervention.
YH
prediction of causal adverse event
a prediction of causal adverse event that is induced by a vaccination.
YH
prediction of causal vaccine adverse event
YH
a pathogen infection adverse event that has an outcome of a fungal infection.
10017533
fungal infection AE
HPO: HP_0002841
SIDER: C0026946
a prediction of causal adverse event that is induced by a drug administration.
YH
prediction of causal drug adverse event
a prediction of causal adverse event that is induced by a usage of a medical device.
YH
prediction of causal medical device adverse event
a prediction of causal adverse event that is induced by a surgery operation.
YH
prediction of causal surgery adverse event
a planned process that leads to the identification of a causal relation between an existing adverse event and a medical intervention.
YH
determination of causal adverse event
an identification of causal adverse event that is induced by a vaccination.
YH
determination of causal vaccine adverse event
an identification of causal adverse event that is induced by a drug administration.
YH
determination of causal drug adverse event
an identification of causal adverse event that is induced by a surgery.
YH
determination of causal surgery adverse event
an identification of causal adverse event that is induced by a usage of a medical device.
YH
determination of causal medical device adverse event
an intrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event.
YH
intrinsic factor of causal adverse event
an extrinsic factor of adverse event that is a determinant factor for the outcome of a causal adverse event.
YH
extrinsic factor of causal adverse event
a role that is extrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include environment, diet, smoking, alcohol use, herbal product, drug-drug interaction.
YH
extrinsic factor of adverse event
a role that is intrinsic to a patient and is associated with an adverse event. No causal effect between this factor and the adverse event is assumed. Examples include: age, race, organ dysfunction, disease, pregrancy, lactation, gender, and genetics.
YH
intrinsic factor of adverse event
YH
an extrinsic factor of adverse event that is from environment.
environment factor of adverse event
YH
an intrinsic factor of adverse event that is the age of a patient.
age factor of adverse event
YH
an intrinsic factor of adverse event that is the race of a patient.
race factor of adverse event
YH
an intrinsic factor of adverse event that is the gender of a patient.
gender factor of adverse event
YH
an intrinsic factor of adverse event that is the organ dysfunction of a patient.
organ dysfunction factor of adverse event
YH
an intrinsic factor of adverse event that is a disease of a patient.
disease factor of adverse event
YH
an intrinsic factor of adverse event that is the pregrancy of a patient.
pregrancy factor of adverse event
YH
an intrinsic factor of adverse event that is the lactation of a patient.
lactation factor of adverse event
YH
an intrinsic factor of adverse event that is the genetics of a patient.
genetics factor of adverse event
a planned process that reports an adverse event.
YH
adverse event reporting
an adverse event reporting that is to report a vaccine adverse event.
YH
vaccine adverse event reporting
an adverse event reporting that is to report a drug adverse event.
YH
drug adverse event reporting
YH
adverse event causality
a quality that represents the level of causality between a medical intervention and an adverse event outcome.
causality of adverse event
YH
a causality level of AE that is definite.
definite AE causality
YH
a causality level of AE that is probable.
probable AE causality
YH
a causality level of AE that is doubtful.
doubtful causality of adverse event
doubtful AE causality
YH
a causality level of AE that is possible.
possible causality of adverse event
potential causality of adverse event
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20.
possible AE causality
an adverse event reporting that is to report a medical device adverse event.
YH
medical device adverse event reporting
an adverse event reporting that is to report a surgery adverse event.
YH
surgery adverse event reporting
an identification of causal drug adverse event that is based on the Naranjo criteria.
YH
S.R. Ahmed. Adverse drug event monitoring at the Food and Drug Administration. J. Gen. Intern. Med. 18 (2003) 57-60.
determination of causal drug adverse event by Naranjo criteria
an identification of causal drug adverse event that is based on the Drug Interaction Probability Scale (DIPS). The DIPS uses a series of questions relating to the potential drug interaction to estimate a probability score. As a comparison, the Naranjo scale has proved to be useful for assessing the causality of adverse events, particularly for single-drug adverse drug reactions. DIPS involves in two drugs: the drug that is affected (object drug) and the drug that causes the change to the object drug (precipitant drug).
YH
J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680.
determination of causal drug adverse event by DIPS
an information content entity that lists one of 10 questions for the Drug Interaction Probability Scale (DIPS).
YH
J. R. Horn, P. D. Hansten, and L Chan. Proposal for a new tool to evaluate drug interaction cases. The Annals of Pharmocotherapy. 2007 April, Volume 41. Page 674-680.
DIPS question
DIPS question 1: Are there previous credible reports of this interaction in humans?
Three answers: Yes (+1), No (-1), and Unk or NA (0)
YH
DIPS question 1
DIPS question 2: Is the observed interaction consistent with the known interactive properties of precipitant drug?
Three answers: Yes (+1), No (-1), and Unk or NA (0)
YH
DIPS question 2
DIPS question 3: Is the observed interaction consistent with the known interactive properties of object drug?
Three answers: Yes (+1), No (-1), and Unk or NA (0)
YH
DIPS question 3
DIPS question 4: Is the event consistent with the known or reasonable time course of the interaction (onset and/or offset)?
Three answers: Yes (+1), No (-1), and Unk or NA (0)
YH
DIPS question 4
DIPS question 5: Did the interaction remit upon dechallenge of the precipitant drug with no change in the object drug?
(if no dechallenge, use Unknown or NA and skip Question 6)
Three answers: Yes (+1), No (-2), and Unk or NA (0)
YH
DIPS question 5
DIPS question 6: Did the interaction reappear when the precipitant drug was readministered in the presence of continued use of object drug?
Three answers: Yes (+2), No (-1), and Unk or NA (0)
YH
DIPS question 6
DIPS question 7: Are there reasonable alternative causes for the event?
Three answers: Yes (-1), No (+1), and Unk or NA (0)
aConsider clinical conditions, other interacting drugs, lack of adherence, risk factors (eg, age, inappropriate doses of object drug). A NO answer presumes that enough information was presented so that one would expect any alternative causes to be mentioned. When in doubt, use Unknown or NA designation.
YH
DIPS question 7
DIPS question 8: Was the object drug detected in the blood or other fluids in concentrations consistent with the proposed interaction?
Three answers: Yes (+1), No (0), and Unk or NA (0)
YH
DIPS question 8
DIPS question 9: Was the drug interaction confirmed by any objective evidence consistent with the effects on the object drug (other than drug concentrations from question 8)?
Three answers: Yes (+1), No (0), and Unk or NA (0)
YH
DIPS question 9
DIPS question 10: Was the interaction greater when the precipitant drug dose was increased or less when the precipitant drug dose was decreased?
Three answers: Yes (+1), No (-1), and Unk or NA (0)
YH
DIPS question 10
an AE causality score that is represented as a score of the Drug Interaction Probability Scale (DIPS).
Score:
Highly Probable: >8
Probable: 5–8
Possible: 2–4
Doubtful: <2
Yongqun He
Drug Interaction Probability Scale
Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.
DIPS score
YH
one of the Naranjo criteria that are frequently used for determination of causality for suspected adverse drug reactions (ADRs).
Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
WEB: http://livertox.nih.gov/Narajo.html
Naranjo criterium
DIPS question 1: Are there previous conclusive reports on this reaction?
Three answers: Yes (+1), No (0), and Don't Know (0)
YH
Naranjo criterium 1
DIPS question 2: Did the adverse reaction appear after the suspected drug was administered?
Three answers: Yes (+2), No (-1), and Don't Know (0)
YH
Naranjo criterium 2
DIPS question 3: Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?
Three answers: Yes (+1), No (0), and Don't Know (0)
YH
Naranjo criterium 3
DIPS question 4: Did the adverse reaction reappear when the drug was readministered?
Three answers: Yes (+2), No (-1), and Don't Know (0)
YH
Naranjo criterium 4
DIPS question 5: Are there alternative causes that could on their own have caused the reaction?
Three answers: Yes (-1), No (+2), and Don't Know (0)
YH
Naranjo criterium 5
DIPS question 6: Did the reaction reappear when a placebo was given?
Three answers: Yes (-1), No (+1), and Don't Know (0)
YH
Naranjo criterium 6
DIPS question 7: Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?
Three answers: Yes (+1), No (0), and Don't Know (0)
YH
Naranjo criterium 7
DIPS question 8: Was the reaction more severe when the dose was increased or less severe when the dose was decreased?
Three answers: Yes (+1), No (0), and Don't Know (0)
YH
Naranjo criterium 8
DIPS question 9: Did the patient have a similar reaction to the same or similar drug in any previous exposure?
Three answers: Yes (+1), No (0), and Don't Know (0)
YH
Naranjo criterium 9
DIPS question 10: Was the adverse event confirmed by any objective evidence?
Three answers: Yes (+1), No (0), and Don't Know (0)
YH
Naranjo criterium 10
a score of the Naranjo adverse drug reaction probability scaling
SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
Yongqun He
Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
WEB: http://livertox.nih.gov/Narajo.html
Naranjo ADR probability score
an adverse event causal association score that represents a probability that an adverse event is caused (induced) by a medical intervention.
For an adverse event this is likely caused by a medical intervention, the causal adverse event (CAE) probabllity is in between 0 and 1. For a known causal adverse event, the CAE probabllity is 1. Alternatively, a CAE probability can be described as a scale that can go beyond the 0-1 range. For example, the Naranjo ADR probabililty score is a score that use scale with a wide range.
YH
CAE probability
causal adverse event probability
a peripheral neuropathy AE which has an outcome of sensory neuropathy that involves damage to nerves of the peripheral nervous system.
YH, AG
sensory neuropathy AE
sensory neuropathy AE
a sensory neuropathy AE which has an outcome of distal sensory neuropathy that involves damage to distal sensory nerves of the peripheral nervous system.
YH, AG
distal sensory neuropathy AE
a distal sensory neuropathy AE that is chronic.
YH, AG
chronic distal sensory neuropathy AE
a neuropathy AE that is induced by a drug administration
AG, YH
neurotoxicity
drug-induced neuropathy AE
Tremor AE is a behavior and neurological AE that has an outcome of an involuntary trembling or quivering, and muscle contraction and relaxation.
SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/tremor.html
10044565
tremor AE
CTCAE: E12837
HPO: HP_0001337
NCIt: C38038
SIDER: C0040822
a neuropathy AE which shows symptoms due to the damage to the autonomic nerves. This damage disrupts signals between the brain and portions of the autonomic nervous system, such as the heart, blood vessels and sweat glands. This can cause decreased or abnormal performance of one or more involuntary body functions.
AG, YH
WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy
WEB: http://www.mayoclinic.org/diseases-conditions/autonomic-neuropathy/basics/definition/con-20029053
10061666
autonomic neuropathy AE
HPO: HP_0002270
SIDER: C0259749
UMLS CUI: C0259749
a peripheral neuropathy AE which is caused by a damage to motor neurons
AG, YH
motor neuropathy AE
A peripheral neuropathy AE which is characterized by damage to more than one nerve
AG, YH, RR
WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html
10036105
polyneuropathy AE
HPO: HP_0001271
SIDER: C0152025
a neuropathy AE which is characterized by isolated damage of a single nerve
AG, YH
10062203
mononeuropathy AE
a peripheral neuropathy AE which affects extremities, such as, toes, fingers, hand and feet.
AG, YH
axonal neuropathy AE
WEB: http://www.livestrong.com/article/184686-distal-neuropathy-symptoms/
distal neuropathy AE
a nervous system AE that affects the neuronal cell body
AG, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922643/
neuronopathy AE
A neuritis AE which has an outcome of mononeuritis characterized by isolated inflammation of one nerve.
AG, YH
10027910
mononeuritis AE
A neuritis AE which has an outcome of polyneuritis characterized by isolated inflammation of many nerves.
AG, YH
polyneuritis AE
a mononeuritis AE which has an outcome of mononeuritis multiplex which involves damage to at least two seperate unrelated nerve area.
AG, YH
mononeuritis multiplex AE
a sensory neuropathy AE which has an outcome of acute sensory neuropathy that is characterized by rapid onset
AG, YH
acute sensory neuropathy AE
a disposition that represents a risk factor associated with the occurrence of an adverse event.
AG, YH
AE risk factor
A data item that is calculated as the number of patients realized with an adverse event beginning in an interval divided by the number of patients taking the same medical intervention within the same interval. The incidence thus indicates the number of newly occurring events over time.
AG, YH
WEB: http://www.crilifetree.com/pdfs/drug-safety/long-term-safety-study-of-morphine-sulfate-and-naltrexone-hydrochloride.pdf
AE incidence rate
a causal adverse drug event that is induced by a drug-drug interaction.
YH, LT
WEB: http://medical-dictionary.thefreedictionary.com/drug+interaction
10013710
causal adverse drug event due to drug-drug interaction
a causal adverse drug event that is induced by a food-drug interaction.
YH, LT
causal adverse drug event due to food-drug interaction
a causal adverse drug event that is induced bygenetic predisposition.
YH, LT
causal adverse drug event due to genetic predisposition
a causal adverse drug event due to genetic predisposition that is specifically induced by SNP.
YH, LT
causal adverse drug event due to SNP
a cardiovascular disorder AE that is a result of insufficient blood flow throughout the body. Shock often accompanies severe injury or illness.
physiological shock AE
shock
WEB: http://en.wikipedia.org/wiki/Shock_%28circulatory%29
WEB: http://njcc.nl/sites/default/files/pdf/review-2_1.pdf
(Lima A. Circulatory shock and peripheral circulatory failure: a historical perspective. Netherlands Journal of Critical Care. 2014. 18:6. 14-18)
WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000039.htm
休克
10040560
Circulatory shock is not related to the emotional state of shock.
Here is the Kumar and Parrilo definition of shock: "The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury".
Reference: Kumar A, Parillo JE. Shock: pathophysiology, classification and approach to management. In: Parrillo JE, Parrillo JE, Bone RC (eds): Critical care medicine: Principles of diagnosis and management. Mosby: Toronto, 1995, pp 371-420.
circulatory shock AE
a psychiatric disorder AE that has an outcome of a loss of brain function and causes a long term and often gradual decrease in the ability to think and remember such that a person's daily functioning is affected.
YH, MW
WEB: https://en.wikipedia.org/wiki/Dementia
痴呆
10012272
Dementia is a loss of brain function that occurs with certain diseases or pathological processes.
dementia AE
HPO: HP_0000726
SIDER: C0497327
A vascular disorder AE that results in the presence of blood clot along the wall of a blood vessel, frequently causing vascular obstruction. Some authorities differentiate thrombus formation from simple coagulation or clot formation.
SS, YH, MW
血栓症; 血栓生成
10043607
thrombosis AE
HPO: HP_0004419
SIDER: C0040053
a metabolic disorder AE that has an outcome of cell death.
SS, YH
10057248
cell death AE
HPO: HP_0010885
SIDER: C0007587
a respiratory system AE which has an outcome of some respiratory tract neoplasm.
YH
10029107
respiratory tract neoplasm AE
competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A
YH, AG, YL
biochemical inhibitor role
YH, AG, YL
WEB: http://en.wikipedia.org/wiki/Agonist
agonist role
YH, AG, YL
WEB: http://en.wikipedia.org/wiki/Receptor_antagonist
In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors.
antagonist role
an inflammation AE that shows the result of an inflammation located in a vein, usually in the legs.
YH, MW
10034879
phlebitis AE
CTCAE:E13815
HPO: HP_0004419
NCIt:C38003
SIDER: C0031542
a liver, biliary, and pancreatic AE that has an outcome of pancreatitis.
YH, MW
10033645
10033646
pancreatitis AE
CTCAE: E10930
HPO: HP_0001733
NCIt: C3306
SIDER: C0030305
a cell death AE that has an outcome of apoptosis.
SS, YH
10059512
apoptosis AE
a cell death AE that has an outcome of necrosis
SS, YH
necrosis AE
HPO: HP_0003713
SIDER: C0027540
A cardiovascular disorder AE that results in Insufficient blood supply for the need of a part of the body, usually as a result of a disease of the blood vessels supplying that part.
SS, YH
ischaemia AE
10061255
Note: also spelt ischemia.
ischemia AE
HPO: HP_0002597
SIDER: C0022116
an adverse event that occurs in hair, skin, or nail.
hair, skin, and nail AE
YH, SS, JX
hair, skin or nail AE
a hair, skin, and nail AE that occurs in hair.
YH, SS
hair AE
a hair, skin, and nail AE that occurs in nail.
YH, SS
nail AE
a metabolism, endocrine, and exocrine system AE that occurs in endocrine system.
10014698
YH, SS
endocrine system AE
a metabolism, endocrine, and exocrine system AE that occurs in exocrine system
YH, SS
exocrine system AE
an adverse event that displays a congential and genetic disorder.
congenital abnormality AE
10010331
YH, SS
congenital AE
a muscular weakness AE that shows weakness or inability to move a body part, often used to describe a neurologic condition.
WEB: https://en.wikipedia.org/wiki/Paresis
局部麻痹
10033800
Neurologists use the term paresis to describe weakness, and plegia to describe paralysis in which all voluntary movement is lost. (Reference: https://en.wikipedia.org/wiki/Paresis)
paresis AE
HPO: HP_0008153
SIDER: C0030552
a syndrome AE that has an outcome of cystic fibrosis, an inherited disease that affects the lungs, digestive system, sweat glands, and male fertility.
YH
WEB: http://medical-dictionary.thefreedictionary.com/cystic+fibrosis
10011762
cystic fibrosis AE
HPO: HP_0006552
SIDER: C0010674
a tumore AE that results in the outcome of hyperplasia, an abnormal increase in the number of normal cells in normal arrangement in an organ or tissue, which increases its volume.
YH, SS
hyperplasia AE
HPO: HP_0010279
SIDER: C0020507
an adverse event that displays a disorder in abdomen.
YH, SS
abdominal AE
an adverse event that results in genetic disorder.
genetic disorder AE
YH, SS
genetic AE
a liver, biliary, and pancreatic AE that has an outcome of hepatitis.
YH
hepatitis AE
HPO: HP_0006562
SIDER: C0019158
an adverse event that displays an outcome of ulcer.
YH, SS
ulcer AE
HPO: HP_0005229
SIDER: C0041582
a musculoskeletal and connective tissue AE that displays an outcome of fistula, a permanent abnormal passageway between two organs in the body or between an organ and the exterior of the body.
WEB: http://medical-dictionary.thefreedictionary.com/fistula
10067143
YH, SS
fistula AE
HPO: HP_0010294
SIDER: C0016169
an abnormal fluid regulation AE which has an outcome of extravasation, a discharge or escape, as of blood, from a vessel into the tissues.
YH, SS
WEB: http://medical-dictionary.thefreedictionary.com/extravasation
10015866
extravasation AE
an adverse event that displays an outcome of an sclerosis, the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue.
YH, SS
sclerosis AE
a crying abnormal AE that has an outcome of abnormal inconsolable crying in a patient
YH
10065283
inconsolable crying AE
a crying abnormal AE that has an outcome of abnormal unusual high-pitched crying in a patient
YH
unusual high-pitched crying AE
a crying abnormal AE that has an outcome of abnormal prolonged crying in a patient
YH
prolonged crying AE
a decreased heart rate AE that results in a resting heart rate of under 60 beats per minutes (BPM).
WEB: http://en.wikipedia.org/wiki/Bradycardia
WEB: http://medical-dictionary.thefreedictionary.com/bradycardia
10006093
bradycardia AE
HPO: HP_0001662
SIDER: C0428977
an adverse event that displays a disorder associated with child birth, newborn infant, or an infant.
pregnancy, neonatal and perinatal disorder AE
10036585
YH, JX
prenatal, perinatal or neonatal disorder AE
an errored drug administration where a patient is administered with an ineffective drug
YH
administration of ineffective drug
an errored drug administration where a patient is administered with an ctive drug with decreased effectiveness
YH
administration of drug with decreased effectiveness
a bupropion-induced adverse event that is induced by aplenzin administration
YH
aplenzin-induced adverse event
an errored drug administration where a patient is administered with a drug above the therapeutic level
YH
drug overdose administration
an errored drug administration where a patient is administered with an drug without knowing the dose used.
YH
administration of drug with omitted dose
a quality that represents resistance of a patient to a drug.
YH
drug resistance
an adverse event that occurs in the site of a medical intervention (e.g., vaccination injection site).
YH
application site reaction
10003055
medical intervention site AE
a site that is used for a medical intervention
YH
medical intervention site
an errored drug administration where a patient is administered with an drug stored in capsule with physical defect
YH
administration of drug stored in capsule with physical defect
an errored drug administration where a patient is administered with an drug with wrong technique
YH
10064353
administration of drug with wrong technique
a drug administration where a patient is administered with an drug with incorrect route
YH
10064304
administration of drug with incorrect route
A pregnancy, neonatal and perinatal AE that displays a disorder associated with newborn infant or an infant.
YH
neonatal AE
A pregnancy, neonatal and perinatal AE that displays a disorder associated with childbirth
YH
perinatal AE
a medical intervention that has an errored medication
YH
10027091
errored medication
a medical intervention that has errored drug medication
SS, YH
10064355
errored drug administration
a therapeutic intervention that uses radiation
YH
radiotherapy
a vascular disorder AE that affects the artery
SS
arterial disease AE
arterial disorder AE
HPO: HP_0002620
SIDER: C0852949
an artery disorder AE that is characterized by a narrowing of the blood vessels outside of the heart.
SS
peripheral artery disease AE
peripheral artery disorder AE
WEB: http://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v%3Aproject=medlineplus&query=peripheral+arterial+disease
10067825
peripheral arterial disease AE
HPO: HP_0004950
SIDER: C1704436
an autoimmune disease AE that shows a symptom of dry red patches on the skin.
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/psoriasis
WEB: https://en.wikipedia.org/wiki/Psoriasis
10037153
psoriasis AE
HPO: HP_0003765
SIDER: C0033860
a distal sensory neuropathy AE characterized by an increase in degree (cumulative)
AG, YH
cumulative distal sensory neuropathy AE
a behavior and neurological AE that has an outcome of stress in a patient
YH
stress AE
an abscess AE that has an outcome of a pocket of infected fluid and pus located inside the abdominal cavity
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000212.htm
10060921
abdominal abscess AE
a discomfort AE that has an outcome of a stomach ache
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Abdominal+discomfort
10000059
abdominal discomfort AE
HPO: HP_0002027
SIDER: C0232487
a sensory capability AE that results in a sensation of elevated abdominal pressure and volume
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0003609/
10000060
abdominal distension AE
CTCAE: E10456
HPO: HP_0003270
NCIt: C78161
SIDER: C0000731
a sepsis AE that has an outcome of sepsis in the abdominal area
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001687/
10058040
abdominal sepsis AE
an abdominal abscess AE that has an outcome of a collection of pus in the abdominal wall, causes inflammation
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002329/
10000099
abdominal wall abscess AE
a behavioral AE that results in uncharacteristic behaviors
12/19/2015: This term became obsolete since its meaning can be quite confusing. "behavior AE" is now considered as the synonym of 'behavioral and neurological AE'.
DJ, SS, YH
abnormal behavior AE
abnormal behaviour AE
behavioral AE
10061422
obsolete: behavior AE
HPO: HP_0000708
SIDER: C0233514
a behavioral and neurological AE that results in odd dreams
DJ, SS, YH
10000125
abnormal dreams AE
an abortion AE that has an outcome of expulsion of a fetus from the uterus brought on intentionally by medication or instrumentation
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/induced+abortion
10000220
abortion induced AE
an abortion AE that results in a miscarriage
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002458/
10000234
abortion spontaneous AE
HPO: HP_0005268
SIDER: C0000786
a skin AE that is characterized by pimples generally on the face, chest and back, caused by clogging of the pores
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/acne
10000496
acne AE
HPO: HP_0001061
SIDER: C0702166
a immune system disorder AE that is caused by the HIV virus
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/hivaids.html
10000565
acquired immunodeficiency syndrome AE
HPO: HP_0002721
SIDER: C0001175
a hematopoietic system AE that has an outcome of a prolonged time taken for blood to clot. The partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. PTT measures the efficacy of the comon coagulation pathways and helps tell if bleeding or clotting problems exist.
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003653.htm
10000636
activated partial thromboplastin time prolonged AE
CTCAE: E12073
HPO: HP_0003645
NCIt: C27028
SIDER: C0853223
a digestive system AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the intestine attack the transplant recipient's body
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm
10066264
acute graft versus host disease in intestine AE
a skin AE that has an outcome of a complication during stem cell or bone marrow transplant in which the newly transplanted donor cells in the skin attack the transplant recipient's body
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm
10066262
acute graft versus host disease in skin AE
a hematopoietic system AE that has an outcome of a type of acute leukemia, characterized by anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, and bone pain
DJ, SS, YH
acute lymphocytic leukaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/Blast+count
10000846
acute lymphocytic leukemia AE
HPO: HP_0006721
SIDER: C0023449
a hematopoietic system AE that has an outcome of the reoccurance of fast-growing cancer of the white blood cells where abnormal blasts do not fight infections after a period of remission
DJ, SS, YH
acute lymphocytic leukaemia recurrent AE
WEB: http://marrow.org/Patient/Disease_and_Treatment/About_Your_Disease/ALL/Acute_Lymphoblastic_Leukemia_(ALL).aspx
10063620
acute lymphocytic leukemia recurrent AE
a hematopoietic system AE that has an outcome of cancer in the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells
DJ, SS, YH
acute myeloid leukaemia AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/
10000880
acute myeloid leukemia AE
HPO: HP_0004808
SIDER: C0023467
an acute myeloid leukemia AE that shows an recurrence of acute myeloid leukemia
DJ, SS, YH
acute myeloid leukaemia recurrent AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001569/
10059034
acute myeloid leukemia recurrent AE
a lung disorder AE that has the outcome fluid accumulation in the air spaces and parenchyma of the lungs with rapid onset
DJ, SS, YH
acute pulmonary oedema AE
WEB: http://medical-dictionary.thefreedictionary.com/Acute+pulmonary+edema
10001029
acute pulmonary edema AE
HPO: HP_0100598
SIDER: C0155919
a respiratory distress AE that has an outcome of a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001164/
10001052
acute respiratory distress syndrome AE
HPO: HP_0002093
SIDER: C0035222
a lung disorder AE that has an outcome of a condition in which not enough oxygen passes from the lungs into the blood, with rapid onset
DJ, SS, YH, MW
WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/rf/
10001053
acute respiratory failure AE
HPO: HP_0002093
SIDER: C0264490
a syncope AE that results in sudden episodes of fainting and sometimes seizures
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518479/
10001115
adams-stokes syndrome AE
a reproductive system AE that results in the thickening of the walls of the uterus. This ccurs when endometrial tissue, which normally lines the uterus, moves into the outer muscular walls of the uterus.
DJ, SS, YH
endrometriosis interma AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002481/
10056268
adenomyosis AE
a viral infection that occurs in the respiratory system and has an outcome of viral infection by nonenveloped icosahedral viruses causing illness in the respiratory system
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Adenovirus+Infections
10060931
adenovirus infection AE
HPO: HP_0004429
SIDER: C0001486
a tumor AE that results in an abnormal number of cells proliferating on the kidney(s)
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22486993
10061588
adrenal neoplasm AE
an endocrine system AE that results in the suppression of the functions of the adrenal glands
DJ, SS, YH
10001382
adrenal suppression AE
a behavior and neurological AE that results in an increase in hostile behavior
DJ, SS, YH
10001488
aggression AE
HPO: HP_0000718
SIDER: C0001807
a hematopoietic system AE that has an outcome of acute leukopenia, or lowered white blood cell count, most commonly of neutrophils causing neutropenia in circulating blood
JX, DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001295.htm
粒性白血球缺乏症
10001507
agranulocytosis AE
HPO: HP_0001913
SIDER: C0001824
an embolism AE that is caused by an air bubble in the vessel
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23295634
10001526
air embolism AE
a liver related investigation result abnormal AE that has an outcome of an abnormal blood level of alanine aminotransferase
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615
10001547
alanine aminotransferase level abnormal AE
an alanine aminotransferase level abnormal AE that has an outcome of a decrease in alanine aminotransferase level in body
DJ, SS, YH, EB
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615
10001549
alanine aminotransferase level decreased AE
an alanine aminotransferase level abnormal AE that has an outcome of elevated levels of alanine transaminase, an enzyme most commonly found in the liver
DJ, SS, YH, EB
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23139615
10001551
alanine aminotransferase level increased AE
CTCAE: E12077
NCIt: C26948
a liver/biliary system AE that is characterized by liver disease caused by the patient's alcoholic activity
DJ, SS, YH
10001627
alcoholic liver disease AE
a behavior and neurological AE that has an outcome of significantly different waking beta wave state
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/20182997
10001854
altered state of consciousness AE
a female reproductive system AE that is characterized by the absence of menstrual period in a woman of reproductive age
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21942684
10001928
amenorrhoea AE
HPO: HP_0000141
SIDER: C0002453
an abnormal fluid regulation AE that results in a decreased volume of amniotic fluid during pregnancy
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22039031
10063356
amniotic fluid volume decreased AE
an anus AE that has an outcome of a split or tear in the mucosa lining the lower rectum
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002116/
10002153
anal fissure AE
HPO: HP_0004378
SIDER: C0016167
an ulcer AE that has an outcome of an ulcer in the anal cavity
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/17073250
10002180
anal ulcer AE
CTCAE: E10496
NCIt: C79536
a vascular disorder AE that has an outcome of a leakage at the site of the intersection of two blood vessels
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23122582
10050456
anastomotic leak AE
a cardiac disorder AE that is stable and shows the symptom of a chest pain due to ischemia of the heart
DJ, SS, YH
stable angina AE
WEB: http://www.heart.org/HEARTORG/Conditions/HeartAttack/SymptomsDiagnosisofHeartAttack/Angina-Pectoris-Stable-Angina_UCM_437515_Article.jsp#
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23016723
10002383
angina pectoris AE
HPO: HP_0001681
SIDER: C0002962
a angina AE that is unstable and has an outcome of a condition in which the heart doesn't get enough blood flow through the blood vessels of the heart muscle, may lead to heart attack.
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001250/
10002388
angina unstable AE
HPO: HP_0001681
SIDER: C0002965
an immunology and allergy investigation result abnormal AE that is characterized by antibodies present that are against cell-membrane phospholipids that provoke blood clots
DJ, SS, YH, EB
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23231732
10048678
antiphospholipid antibodies positive AE
a urinary system AE that has an outcome of the absence of urine formation
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/anuria
10002847
anuria AE
HPO: HP_0100519
SIDER: C0003460
a vascular disorder AE that results in a condition affecting the aorta and aortic valves
DJ, SS, YH
WEB: http://www.rightdiagnosis.com/medical/aorta_disorder.htm
10058648
aortic disorder AE
HPO: HP_0001679
SIDER: C0003493
a cardiac valve disease AE that has an outcome of inability of the aortic valve to function effectively
DJ, SS, YH
WEB: http://www.rightdiagnosis.com/a/aortic_valve_incompetence/intro.htm
10002915
aortic valve incompetence AE
HPO: HP_0001659
SIDER: C0003504
a congenital abnormality AE with an outcome of defective development or congenital absense of an organ or tissue
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/737831
10002961
aplasia AE
HPO: HP_0010515
SIDER: C0243065
Aplastic anaemia AE is an anemia AE that occurs when the bone marrow, and the blood stem cells that reside there are damaged. This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia).
DJ, SS, JX, YH
aplastic anemia
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23292240
再生障碍性贫血
10002967
aplastic anaemia AE
HPO: HP_0001915
SIDER: C0002874
a serious AE that is due to an allergic brochospasm, which causes a serious problem with breathing and requires treatment in an emergency room.
YH, JX
URL: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
URL: https://en.wikipedia.org/wiki/Bronchospasm
allergic brochospasm AE that requires treatment in emergency
a hypersensitivity AE that occurs at the site of an application of a medical intervention (e.g., drug administration or vaccination).
DJ, SS, YH
10063683
application site hypersensitivity AE
an infection AE that occurs at the site of drug application
DJ, SS, YH
10049041
application site infection AE
a hemorrhage AE that has an outcome of bleeding in the arteries
DJ, SS, YH
arterial bleeding AE
arterial haemorrhage AE
10060964
arterial hemorrhage AE
CSF protein increased AE is an abnormal cerebrospinal fluid production that results in and increase in blood level CSF protein
SS, YH
10011575
CSF protein increased AE
a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of an abnormal result in the cerebrospinal fluid (CSF) collection test that examines the fluid that surrounds the brain and spinal cord
This should be inferred as a "AE: lab test abnormal".
SS, YH, EB
WEB: www.nlm.nih.gov/medlineplus/ency/article/003428.htm
10059703
CSF test result abnormal AE
Henoch-Schonlein purpura AE is a purpura AE, a systemic vasculitis (inflammation of blood vessels) characterized by deposition of immune complexes containing the antibody IgA in the skin and kidney. This results from some allergic response,
SS, YH
allergic purpura, anaphylactoid purpura, vascular purpura
WEB: http://en.wikipedia.org/wiki/Henoch-Schonlein_purpura
10019617
Henoch-Schonlein purpura AE
HPO: HP_0000979
SIDER: C0034152
SS, YH
WEB: http://en.wikipedia.org/wiki/Abasia
10049460
a movement disorder AE that has an outcome of abasia, a movement disorder that results in and inability to walk due to impaired muscle coordination
abasia AE
HPO: HP_0002540
SIDER: C0877217
a stomach pain AE that is observed in upper stomach
SS, YH
10000087
abdominal pain upper AE
HPO: HP_0002027
SIDER: C0232492
a behavior and neurological AE that has an outcome of loss of taste functions of the tongue, particularly the inability to detect sweetness, sourness, bitterness, saltiness, and umami (the taste of monosodium glutamate).
SS, YH
WEB: http://en.wikipedia.org/wiki/Ageusia
10001480
ageusia AE
a sensory neuropathy AE that has an outcome of chronic sensory neuropathy characterized by being persistent or long-lasting in nature
AG, YH
chronic sensory neuropathy AE
a behavior and neurological AE that has an outcome of a lack of functioning olfaction, an inability to perceive odors
SS, YH
WEB: http://en.wikipedia.org/wiki/Olfaction
10002653
anosmia AE
HPO: HP_0010632
SIDER: C0003126
a psychiatric disorder AE that has an outcome of a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create an unpleasant feeling that is typically associated with uneasiness, fear, or worry.
SS, YH
WEB: http://en.wikipedia.org/wiki/Anxiety
10002855
anxiety AE
CTCAE: E12883
HPO: HP_0000739
NCIt: C26696
SIDER: C0003467
an arrhythmia AE that is characterized by rapid regular atrial contractions occurring usually at rates between 250 and 400 per minute and often producing saw-tooth waves in an electrocardiogram.
SS
AF
auricular flutter
WEB: http://medical-dictionary.thefreedictionary.com/atrial+flutter
10003662
atrial flutter AE
CTCAE: E10087
HPO: HP_0004749
NCIt: C51224
SIDER: C0004239
a behavior and neurological AE that has an outcome of a disturbance that causes an individual to feel unsteady, giddy, woozy, or have a sensation of movement, spinning, or floating.
SS, YH
WEB: http://en.wikipedia.org/wiki/Balance_disorder
10049848
balance disorder AE
HPO: HP_0002141
SIDER: C0575090
blister AE is a skin adverse event that results in a small pocket of fluid within the upper layers of the skin
SS, YH
WEB: http://en.wikipedia.org/wiki/Blister
10005191
blister AE
HPO: HP_0008066
SIDER: C0005758
cellulitis AE is an inflammation AE that is a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin
SS, YH
WEB: http://en.wikipedia.org/wiki/Cellulitis
10007882
cellulitis AE
HPO: HP_0003553
SIDER: C0007642
a behavior and neurological AE that has an outcome of a type of perspiration usually associated with anxiety or fear
SS, YH
WEB: http://en.wikipedia.org/wiki/Cold_sweat
cold sweat AE
convulsion AE is a muscle adverse event that results in a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body
SS, YH
WEB: http://en.wikipedia.org/wiki/Convulsion
10010904
convulsion AE
HPO: HP_0001250
SIDER: C0009951
SS, YH
a movement disorder AE that has an outcome of difficulty in walking properly
difficulty in walking AE
a behavior and neurological AE that has an outcome of distortion of the sense of taste
SS, YH, MW
WEB: http://en.wikipedia.org/wiki/Dysgeusia
10013911
dysgeusia AE
CTCAE:E12643
HPO: HP_0000223
NCIt:C28145
SIDER: C0013378
a movement disorder AE that has an outcome of dyskinesia
SS, YH
WEB: http://en.wikipedia.org/wiki/Dyskinesia
10013916
dyskinesia is a movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements
dyskinesia AE
HPO: HP_0100660
SIDER: C0013384
dyspnoea AE is an abnormal respiration AE debilitating symptom that is the experience of unpleasant or uncomfortable respiratory sensations, shortness of breath, air hunger
MedDRA: 10013968 is for "dyspnoea"; MedDRA: 10013963 is for "dyspnea".
SS, YH
dyspnoea AE
WEB: http://en.wikipedia.org/wiki/Dyspnoea
10013963
10013968
dyspnea AE
CTCAE: E13368
HPO: HP_0002094
NCIt: C2998
SIDER: C0013404
UMLS CUI: C0013404
SS, YH, EB
WEB: http://en.wikipedia.org/wiki/Electromyography
10014431
a neurological, special senses and psychiatric investigation result abnormal AE that has an outcome of abnormal activity in skeletal muscles evaluted and measured by electromyography
electromyogram result abnormal AE
eye irritation AE is an eye disorder AE that results in mild eye redness, itching, or tearing
SS, YH
WEB: http://www.freemd.com/eye-irritation/
10015946
eye irritation AE
HPO: HP_0000478
SIDER: C0235266
eye pruritus AE is a pruritus AE (an unpleasant sensation that evokes the desire or reflex to scratch) at the eye area
SS, YH
10052140
eye pruritus AE
HPO: HP_0000989
SIDER: C0022281
glomerulonephritis AE is a kidney disorder AE that results in a renal disease that is characterized by inflammation of the glomeruli, or small blood vessels in the kidneys.
SS, YH
glomerular nephritis AE
WEB: http://en.wikipedia.org/wiki/Glomerulonephritis
glomerulonephritis AE
HPO: HP_0000099
SIDER: C0017658
A conduction system disorder AE that is a condition in which the electrical impulse from the bundle of His to the ventricles is delayed or fails to conduct along the right bundle branch, resulting in right ventricular depolarization by cell-to-cell conduction spreading from the interventricular septum and left ventricle to the right ventricle–ie, slow and uncoordinated Natural history Surgically induced RBBB has few acute hemodynamic consequences and a generally benign course long term; rarely, progression to complete heart block and sudden death occur, especially if accompanied by major His-Purkinje system–eg, left anterior hemiblock, first-degree AV block–injury; tetralogy of Fallot repair with an RBBB and a markedly prolonged QRS duration >180 ms have an ↑ risk for ventricular arrhythmias and sudden death.
SS
RBBB
right bundle branch block
WEB: http://medical-dictionary.thefreedictionary.com/right+bundle+branch+block
10006582
bundle branch block right AE
HPO: HP_0011712
SIDER: C0085615
a cardiac disorder AE of the electrical conduction system that controls the heart rate, generates and conducts electrical impulses throughout the muscle of the heart, stimulating the heart to contract and pump blood.
SS
cardiac conduction disorder AE
conduction disorder AE
WEB: http://www.medterms.com/script/main/art.asp?articlekey=8407
10000032
10010276
conduction system disorder AE
CTCAE: E10114
NCIt: C78245
a sensory capability AE that has an outcome of hypoaesthesia, meaning that skin loses some of its sensitivity to pain or touch
SS, YH
disesthesia AE
hypoaesthesia AE
WEB:http://medguides.medicines.org.uk/document.aspx?name=hypoaesthesia
10020937
hypoesthesia AE
HPO: HP_0010830
SIDER: C0020580
a thrombosis AE that has an outcome of a blood clot within an artery
[SS] Per DRA and KKB's comment, arterial thrombosis may also be characterized as an embolism.
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23236330
10003178
arterial thrombosis AE
HPO: HP_0004420
SIDER: C0151942
a viral infection AE that demonstrates an influenza viral infection. Influenza is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses), that affects birds and mammals
SS, YH
WEB: http://en.wikipedia.org/wiki/Influenza
influenza AE
HPO: HP_0005376
MDR: 10022000
SIDER: C0021400
a coronary artery disease AE with the outcome hardening of the coronary artery due to a build up of waxy plaque on the inside of blood vessels
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Coronary+Arteriosclerosis
10003211
arteriosclerosis coronary artery AE
HPO: HP_0004929
SIDER: C0010054
injected limb mobility decreased AE is a mobility decreased AE that occurs in the limb in which injection is administered
SS, YH
injected limb mobility decreased AE
a haematoma AE that has an outcome of injection-site haematoma, which results in a collection of blood outside the blood vessels at the physical area of injection
SS, YH
injection-site haematoma AE
WEB: http://medical-dictionary.thefreedictionary.com/hematoma
http://en.wikipedia.org/wiki/Hematoma
10022066
injection-site hematoma AE
injection-site induration AE is an skin AE that results in hardening or thickening of tissue at the physical injection site
SS, YH
WEB: http://wordnetweb.princeton.edu/perl/webwn?s=induration
injection-site induration AE
injection-site pruritus AE is an pruritus AE that results in an unpleasant sensation that evokes the desire or reflex to scratch at the physical area of injection
SS, YH
WEB: http://en.wikipedia.org/wiki/Itch
WEB: http://medical-dictionary.thefreedictionary.com/pruritus
10022093
injection-site pruritus AE
injection-site rash AE is a rash AE that results in a change of the skin which affects its color, appearance or texture at the physical injection site
SS, YH
WEB: http://en.wikipedia.org/wiki/Rash
injection-site rash AE
injection-site warmth AE is a homeostasis AE that results in feeling of warmth at the physical injection site
SS, YH
injection-site warmth AE
A joint disorder AE that has an outcome of joint swelling, which is a joint disorder that results in a buildup of fluid in the soft tissue surrounding the joint
SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003262.htm
10023232
joint swelling AE
HPO: HP_0005833
SIDER: C0152031
an adverse event that occurs in kidney.
SS, YH
10038428
kidney AE
a behavior and neurological AE that has an outcome of an increase in production, secretion, and shedding of tears
SS, YH
WEB: http://en.wikipedia.org/wiki/Tears
WEB: http://www.medterms.com/script/main/art.asp?articlekey=6199
10023644
lacrimation increased AE
HPO: HP_0009926
SIDER: C0152227
lip swelling AE is an edema (swelling) AE that results in enlargement or protuberance in the lip
SS, YH
WEB: http://en.wikipedia.org/wiki/Swelling_%28medical%29
10024570
lip swelling AE
HPO: HP_0000159
SIDER: C0240211
A lymphadenopathy AE that results in swollen/enlarged lymph nodes
SS, YH
WEB: http://en.wikipedia.org/wiki/Lymphadenopathy
lymphadenitis AE
HPO: HP_0002840
SIDER: C0024205
mobility decreased AE is a nervous system AE that results in difficulty in movement leading to less ability to move part(s) of body
SS, YH
10048334
mobility decreased AE
HPO: HP_0006217
SIDER: C0700572
a muscle AE that has an outcome of muscular weakness AE (i.e., lack of muscle strength).
SS, YH
WEB: http://en.wikipedia.org/wiki/Muscular_weakness
10028372
muscular weakness AE
HPO: HP_0001324
SIDER: C0151786
a sensory capability AE that has an outcome of a sensation of stiffness in muscles and skeleton
SS, YH
10052904
musculoskeletal stiffness AE
HPO: HP_0003552
SIDER: C0948525
nasal congestion AE is a respiratory system AE that results in a blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels
SS, YH
WEB: http://en.wikipedia.org/wiki/Nasal_congestion
10028735
nasal congestion AE
CTCAE: E13450
HPO: HP_0001742
NCIt: C78500
SIDER: C0027424
a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system
a respiratory system inflammation AE which has an outcome of nasopharyngitis, a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system
SS, YH
common cold AE
WEB: http://en.wikipedia.org/wiki/Nasopharyngitis
nasopharyngitis AE
HPO: HP_0002087
SIDER: C0027441
an neuropathy AE that results in a damage to the peripheral nervous system (PNS, outside the brain and spinal cord), the vast communication network that transmits information from the brain and the spinal cord (the central nervous system) to every other part of the body.
SS, YH
neuropathy peripheral AE
WEB: http://en.wikipedia.org/wiki/Peripheral_neuropathy
WEB: http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm
10029331
peripheral neuropathy AE
ocular hyperaemia AE is an eye disorder AE that results in severe redness and irritation of the eyes
SS, YH
ocular hyperaemia AE
WEB: http://www.med.miami.edu/news/view.asp?id=259
10030041
ocular hyperemia AE
a pain AE that has an outcome of oropharyngeal pain
SS, YH
WEB: http://en.wikipedia.org/wiki/Oropharyngeal_airway
10068319
oropharyngeal pain is a pain in oral airway
oropharyngeal pain AE
HPO: HP_0010833
SIDER: C2363731
an ear disorder AE which has an outcome of otitis media that results in inflammation of the middle ear, or middle ear infection
SS, YH
WEB: http://en.wikipedia.org/wiki/Otitis_media
10033078
otitis media AE
CTCAE: E11477
HPO: HP_0008623
NCIt: C34885
SIDER: C0029882
an inflammation AE that has an outcome of pericaditis, which is a cardiovascular disorder that results in a condition in which the sac-like covering around the heart (pericardium) becomes inflamed
SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000182.htm
10034484
pericarditis AE
CTCAE: E10180
HPO: HP_0001701
NCIt: C34915
SIDER: C0031046
pharyngeal edema AE is an edema AE that results in an bbnormal fluid accumulation in TISSUES or body cavities in pharynx (throat swelling).
SS, YH
pharyngeal oedema AE
WEB: http://www.ncbi.nlm.nih.gov/mesh/68004487?ordinalpos=1&itool=EntrezSystem2.PEntrez.Mesh.Mesh_ResultsPanel.Mesh_RVDocSum
pharyngeal edema AE
pharyngitis AE is a digestive system AE that results in an inflammation of the throat or pharynx
SS, YH
WEB: http://en.wikipedia.org/wiki/Pharyngitis
10034835
pharyngitis AE
CTCAE: E11525
HPO: HP_0100776
NCIt: C26851
SIDER: C0031350
a pain AE that shows a pain in sinus and throat
SS, YH, MW
WEB: http://www.wordinfo.info/words/index/info/view_unit/1631/
10034844
pharyngolaryngeal pain AE
CTCAE: E13482
HPO: HP_0010833
NCIt: C78556
SIDER: C0858635
rash macular AE is a rash AE that results in a skin eruption in which the lesions are flat and less than 1 cm in diameter
SS, YH
rash macular AE
WEB: http://medical-dictionary.thefreedictionary.com/macular+rash
macular rash AE
HPO: HP_0000988
SIDER: C0221201
a rash AE that shows clustered papules, i.e., small, round, raised bumps that have clear borders.
SS, YH
rash papular AE
WEB: http://en.wikipedia.org/wiki/Rash
WEB: http://www.healthline.com/symptom/papule
WEB: http://www.rightdiagnosis.com/sym/papular_rash.htm
10037876
papular rash AE
HPO: HP_0007432
SIDER: C0221202
respiratory distress AE is a respiratory system AE that results in a severe lung disease caused by a variety of direct and indirect issues. It is characterized by inflammation of the lung parenchyma leading to impaired gas exchange with concomitant systemic release of inflammatory mediators causing inflammation, hypoxemia and frequently resulting in multiple organ failure.
SS, YH
WEB: http://en.wikipedia.org/wiki/Acute_respiratory_distress_syndrome
10038687
respiratory distress AE
HPO: HP_0002747
SIDER: C0476273
respiratory tract congestion AE is a respiratory system AE that results in congestion in respiratory tract
SS, YH
respiratory tract congestion AE
retching AE is a digestive system AE that results in a process in the human body where gastric (and sometimes duodenal) contents are forced into the esophagus, but do not enter the pharynx
SS, YH
WEB: http://en.wikipedia.org/wiki/Retching
10038776
retching AE
rhinitis AE is a respiratory system inflammation characterized by runny nose,irritation and inflammation of some internal areas of the nose
SS, YH
runny nose
WEB: http://en.wikipedia.org/wiki/Rhinitis
WEB: http://medical-dictionary.thefreedictionary.com/rhinitis
10028116
rhinitis AE
HPO: HP_0002257
SIDER: C0035455
rhinorrhoea AE is a respiratory system AE that results in runny nose, an unusually significant amount of nasal fluid
SS, YH
rhinorrhoea AE
WEB: http://en.wikipedia.org/wiki/Rhinorrhoea
rhinorrhea AE
a pain AE that occurs in shoulder
shoulder pain is a pain iin or around the shoulder joint
SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003171.htm
shoulder pain AE
sinus congestion AE is a nasal congestion AE that results in blockage of the air cavities in the cranial bones or nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels
SS, YH
WEB: http://en.wikipedia.org/wiki/Sinus_%28anatomy%29, http://en.wikipedia.org/wiki/Nasal_congestion
sinus congestion AE
HPO: HP_0002257
SIDER: C0152029
sneezing AE is a respiratory system adverse event that results in sternutation, a semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth, usually caused by foreign particles irritating the nasal mucosa
SS, YH, MW
sternutation
WEB: http://en.wikipedia.org/wiki/Sneezing
10041232
sneezing AE
CTCAE:E13572
NCIt:C50746
an increased heart rate AE where the heart rate exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual)
SS, YH
WEB: http://en.wikipedia.org/wiki/Tachycardia
10043071
tachycardia AE
HPO: HP_0001649
SIDER: C0039231
a tendon disorder AE that has an outcome of tendonitis
SS, YH
tendinitis AE
WEB: http://en.wikipedia.org/wiki/Tendinitis
tendonitis is a tendon disorder that results in an inflammation of a tendon
tendonitis AE
HPO: HP_0100261
SIDER: C0039503
a sensory capability AE that has an outcome of a sensation of tightness in the throat
10043528
throat tightness AE
an infection AE is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx
SS, YH
URI, URTI
WEB: http://en.wikipedia.org/wiki/Upper_respiratory_tract_infection
10046300
upper respiratory tract infection AE
CTCAE: E11604
HPO: HP_0002788
NCIt: C35650
SIDER: C0041912
a viral infection AE that results in an acute contagious diseased caused by herpes varicella zoster virus; causes a rash of vesicles on the face and body.
SS, YH
chicken pox AE
varicella zoster virus infection AE
WEB: http://wordnetweb.princeton.edu/perl/webwn?s=varicella
varicella AE
HPO: HP_0005428
SIDER: C0008049
a paresthesia AE that occurs in oral area.
SS, YH
paraesthesia oral AE
http://www.answers.com/topic/oral-paresthesia
10057372
paraesthesia oral is a paresthesia that results in a numbness or tingling that occurs in the mucosa or tissues of the oral cavity.
paresthesia oral AE
HPO: HP_0003401
SIDER: C0521591
an abnormal body temperature AE which has an outcome of fever
YH, SS, MW
body temperature increased AE
febrile response
pyrexia AE
Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828.
WEB: http://en.wikipedia.org/wiki/Pyrexia
10005911
10016558
10037660
Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1-2 °F).
fever AE
CTCAE: E11102
NCIt: C3038
a skin AE that shows the symptom of rash, i.e., an abnormal change in skin color, appearance, or texture. A rash may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful.
YH
URL: http://en.wikipedia.org/wiki/Rash
URL: http://www.webmd.com/skin-problems-and-treatments/guide/common-rashes
Wick JY. Drug-induced rash: nuisance or threat? Consult Pharm. 2013 Mar;28(3):160-6. PMID: 23462025.
10037844
Drug-induced rash is the most commonly reported drug reaction.
rash AE
HPO: HP_0000988
SIDER: C0015230
an adverse event that has an outcome of a pathogen infection, i.e., an infection caused by a pathogen such as a virus, bacterium, or parasite.
change of name from 'infection adverse event' to 'infectious adverse event' on 09/23/13 for a better clinical relevance, move 'infection adverse event' as an alternative term - SS
YH, JX
infectious adverse event
WEB: http://medical-dictionary.thefreedictionary.com/infection
infection
10021789
infection AE
An AE that has an outcome of syndrome. Syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others.
YH
syndrome AE
a psychiatric disorder AE that has an outcome of emotional state of excitement or restlessness
YH, MW
10001497
agitation AE
CTCAE:E12874
HPO: HP_0000711
NCIt:C79530
SIDER: C0085631
injection-site AE is an AE that occurs in an injection site (e.g., during vaccination).
YH, JX, SS
injection site AE
injection-site adverse event
injection-site reaction
local reaction AE
10022095
injection-site AE
CTCAE: E11138
NCIt: C3508
a hypersensitivity AE which has an outcome of injection-site hypersensitivity
YH
injection-site hypersensitivity AE
an edema AE which occurs at the injection site. In this case, a collection of fluid at the injection site is found.
YH, RR
injection-site oedema AE
injection-site swelling AE
WEB: http://www.uptodate.com/contents/edema-swelling-beyond-the-basics
10053425
injection-site edema AE
a pain AE that occurs in an injection site of a medical intervention
YH
10022086
injection-site pain AE
an inflammation AE which has an outcome of injection-site inflammation
YH
injection-site inflammation AE
a hemorrhage AE that has an outcome of injection-site hemorrhage
YH
10022067
injection-site hemorrhage AE
a tumor or mass AE that occurs in an injection-site
YH, SS
injection site nodule AE
injection-site mass is a mass at physical injection site
injection-site mass AE
a skin adverse event that has an outcome of pruritus
YH, SS, MW
itch
itching
pruritus generalised AE
WEB: http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=DetailsSearch&term=pruritus+generalised&log$=activity
10037087
Pruritus is an itch (Latin: pruritus), i.e., an unpleasant sensation that evokes the desire or reflex to scratch.
pruritus AE
CTCAE:E13686
HPO: HP_0000989
NCIt:C3344
SIDER: C0033774
a sensory capability AE that has an outcome of pain in a patient
YH, MW
10033371
pain AE
CTCAE: E11167
HPO: HP_0010833
NCIt: C3303
SIDER: C0030193
a pain AE that has outcome of myalgia. Myalgia means "muscle pain" and is a symptom of many diseases and disorders.
YH, MW
muscle pain AE
10028411
myalgia AE
CTCAE:E12485
HPO: HP_0003326
NCIt:C27009
SIDER: C0231528
Urticaria AE is a rash AE notable for dark red, raised, itchy bumps.
YH, MW
hives
10046735
urticaria AE
CTCAE:E13746
HPO: HP_0001025
NCIt:C3432
SIDER: C0042109
a pain AE that has an outcome of headache
YH, MW
10019211
headache AE
CTCAE: E12678
HPO: HP_0002315
NCIt: C34661
SIDER: C0018681
an AE that occurs in respiratory system.
I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He
YH
respiratory system AE
a leukocyte cell number abnormal AE that has an outcome of greater than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
According to the Vaccine Adverse Event Reporting System (VAERS), 'leukocytosis' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543).
SS, YH, EB
increased leukocyte cell number AE
leukocytosis AE
white blood cell count increased AE
WEB: http://en.wikipedia.org/wiki/Leukocytosis
10024378
10047943
leukocyte cell number increased AE
CTCAE: E10048
MP: MP_0000218
NCIt: C35524
a leukocyte cell number abnormal AE that has an outcome of reduction in the number of leukocytes, or of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
According to the Vaccine Adverse Event Reporting System (VAERS), 'leukopenia' is an adverse event that was mentioned in 417 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
decreased leukocyte cell number AE
white blood cell count decreased AE
10047942
leukocyte cell number decreased AE
CTCAE: E12232
MP: MP_0000221
NCIt: C26816
a cardiovascular disorder AE that has an outcome of abnormal blood pressure, representing altered tension of the blood within the systemic arteries
abnormal blood pressure AE
MP: MP_0000230
a muscle adverse event which has an outcome of asthenia, which is a medical term denoting symptoms of physical weakness and loss of strength.
YH
10003549
asthenia AE
HPO: HP_0001324
SIDER: C0004093
a muscle pain AE that has an outcome of muscle ache.
YH
muscle ache AE
A rash AE that shows a flat, red area on the skin overed with small confluent bumps.
YH, MW
maculopapular rash AE
rash maculo-papular AE
rash maculopapular AE
WEB: http://en.wikipedia.org/wiki/Maculopapular_rash
10037868
The term "maculopapular" is a compound: macules are small, flat discolored spots on the surface of the skin; and papules are small, raised bumps.
maculo-papular rash AE
CTCAE:E13700
NCIt:C75579
An joint disorder AE that has an outcome of arthralgia. Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory.
YH, MW
10003239
arthralgia AE
CTCAE:E12374
HPO: HP_0002829
NCIt:C50464
SIDER: C0003862
vesiculobullous rash AE is a rash AE characterized by serous-fluid-filled vesicles (blisters)
YH
vesiculobullous rash AE
HPO: HP_0000988
SIDER: C0151883
a syndrome AE which has an outcome of screaming syndrome
YH
screaming syndrome AE
a sensory capability AE that has an outcome of dizziness
YH, SS, MW
10013573
Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs.
dizziness AE
CTCAE:E12631
HPO: HP_0002321
NCIt:C37943
SIDER: C0012833
peripheral edema AE is an edema AE that results in swelling of tissues, usually in the lower limbs, due to the accumulation of fluids
YH, SS
edema peripheral AE
oedema peripheral AE
peripheral edema AE
WEB: http://en.wikipedia.org/wiki/Peripheral_edema
10030124
10050068
edema limbs AE
CTCAE: E11086
NCIt: C78262
a sensory capability AE that has an outcome of malaise
YH
10025482
Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise.
malaise AE
CTCAE: E11152
HPO: HP_0002321
NCIt: C3832
SIDER: C0231218
a behavior and neurological AE that has an outcome of somnolence
YH, SS, MW
drowsiness
10041349
Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia).
somnolence AE
CTCAE:E12814
HPO: HP_0001262
NCIt:C26754
SIDER: C2830004
a sensory neuropathy AE that shows a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect.
YH, MW
paraesthesia AE
WEB: http://en.wikipedia.org/wiki/Paraesthesia
10033775
10033987
Paresthesia is more generally known as the feeling of "pins and needles" or of a limb being "asleep" (although this is not directly related to the phenomenon of sleep). The manifestation of paresthesia may be transient or chronic.
paresthesia AE
CTCAE: E12758
NCIt: C28177
a behavior and neurological AE that has an outcome of abnormal crying in a patient
YH
10011469
crying abnormal AE
a sensory capability AE that has an outcome of chills
YH
feeling cold AE
10008531
Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold.
chills AE
CTCAE: E11074
HPO: HP_0001945
NCIt: C35143
SIDER: C0085593
a behavior and neurological AE that has an outcome of stupor
YH
10042264
Stupor is the lack of critical cognitive function and level of consciousness wherein a sufferer is almost entirely unresponsive and only responds to base stimuli such as pain. The word derives from the Latin stupure, meaning insensible. Being characterised by impairments of reactions to external stimuli, in this case, vaccine immunization.
stupor AE
HPO: HP_0004372
SIDER: C0085628
a gustatory system AE which demonstrates a decreased sensation of appetite.
YH, MW
anorexia nervosa AE
decreased appetite AE
WEB: http://www.mayoclinic.org/diseases-conditions/anorexia/basics/definition/con-20033002
厌食症
10002646
10002649
10061428
anorexia AE
CTCAE: E12252
HPO: HP_0002039
NCIt: C2875
SIDER: C0003123
face edema AE is an edema AE that results in facial swelling, the build-up of fluid in the tissues of the face. Swelling may also affect the neck and upper arms
YH, SS, MW
emema face AE
face oedema AE
oedema face AE
WEB:http://www.nlm.nih.gov/medlineplus/ency/article/003105.htm
swelling face
10014222
10016029
10042682
face edema AE
CTCAE: E11082
NCIt: C78289
an abnormal respiration AE that shows a sudden and often repetitively occurring reflex to keep the throat and airways clear
YH, SS, MW
coughing AE
WEB: http://medical-dictionary.thefreedictionary.com/cough
WEB: http://www.nlm.nih.gov/medlineplus/cough.html
cough
10011224
cough AE
CTCAE:E13364
NCIt:C37935
a syndrome AE that has an outcome of a flu syndrome AE and occurs after a medical intervention.
YH
flu-like symptom AE
flu syndrome AE
CTCAE: E11108
NCIt: C78302
a sensory capability AE that has an outcome of loss of consciousness, fainting
YH, SS, MW
Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness.
fainting
WEB: http://en.wikipedia.org/wiki/Syncope_%28medicine%29
WEB: http://en.wikipedia.org/wiki/Unconsciousness
10024855
10042772
syncope AE
CTCAE: E12832
HPO: HP_0001279
NCIt: C35053
SIDER: C0039070
a skin adverse event that has an outcome of sweating
According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,301 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543).
YH
sweating AE
HPO: HP_0000975
SIDER: C0038990
According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543).
YH, SS
WEB: http://en.wikipedia.org/wiki/Abdominal_pain
10000081
a pain AE that is observed in abdominal cavity
abdominal pain AE
HPO: HP_0002027
SIDER: C0000737
an abnormal blood pressure AE that has an outcome of sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states
YH, SS, MW
blood pressure increased
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21722707
10005750
10020772
hypertension AE
CTCAE: E13785
HPO: HP_0000822
MP: MP_0000231
NCIt: C3117
SIDER: C0020538
a cardiac valve disease AE that is characterized by a condition of the heart in which the aortic valve, located between the aorta and left ventricle of the heart, is norrower than normal size
SS
WEB: http://medical-dictionary.thefreedictionary.com/aortic+valve+stenosis
10002918
aortic valve stenosis AE
HPO: HP_0005173
SIDER: C0003507
a muscular weakness AE that has an outcome of myasthenia. Myasthenia represenats myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatiguability.
YH, SS
myasthenia gravis
myasthenia syndrome AE
myasthenic syndrome AE
myasthenia AE
HPO: HP_0001324
SIDER: C0947912
a pain AE that occurs at the chest
According to the Vaccine Adverse Event Reporting System (VAERS), 'chest pain' was mentioned in 1,752 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543).
YH
10008479
chest pain AE
HPO: HP_0001681
SIDER: C0008031
a sensory neuropathy AE which has an outcome of sensory axonal characterized by damage to axonas of the peripheral nervous system (PNS)
AG, YH
sensory axonal AE
an abnormal vision AE characterised by leakage of fluid under the retina causing visual impairment, usually in one eye.
SJ, YH
central serous chorioretinopathy
WEB: http://en.wikipedia.org/wiki/Central_serous_retinopathy
10063118
central serous retinopathy AE
a movement disorder AE that has an outcome of twitching, an involuntary sudden movement of part of the body.
According to the Vaccine Adverse Event Reporting System (VAERS), 'twitching' is an adverse event that was mentioned in 1,511 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543).
YH
twitching AE
a seizure AE that has an outcome of febrile seizure
YH
febrile seizure AE
a respiratory system AE which has an outcome of asthma
YH
哮喘
10003553
Asthma is a common chronic lung disease. It has been defined by the National Heart, Lung and Blood Institute as a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness (bronchospasm), and an underlying inflammation.
asthma AE
HPO: HP_0002099
SIDER: C0004096
a pain AE that has an outcome of neck pain
According to the Vaccine Adverse Event Reporting System (VAERS), 'neck pain' was mentioned in 1,323 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543).
YH, MW
10028836
neck pain AE
CTCAE: E12493
HPO: HP_0003418
NCIt: C50663
SIDER: C0007859
an arthritis AE that has an outcome of inflammation of a joint, resulting from infectious agents, such as bacteria and viruses
DJ, SS, YH
WEB: http://www.rightdiagnosis.com/i/infectious_arthritis/intro.htm
10060968
arthritis infective AE
HPO: HP_0003095
SIDER: C0003869
a pain AE that has an outcome of back pain
According to the Vaccine Adverse Event Reporting System (VAERS), 'back pain' was mentioned in 1,277 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543).
YH, MW
10003988
back pain AE
CTCAE:E12388
HPO: HP_0003418
NCIt:C41830
SIDER: C0004604
a hair AE that has an outcome of alopecia and occurs after a medical intervention.
VAE, MW
10001760
alopecia means the absence of hair or loss of hair. It is not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition.
alopecia AE
CTCAE:E13611
HPO: HP_0001596
MP: MP_0000414
NCIt:C50575
SIDER: C0002170
a hemorrhage AE that has an outcome of gastrointestinal hemorrhage
gastrointestinal haemorrhage AE
WEB: http://medical-dictionary.thefreedictionary.com/gastrointestinal+hemorrhage
10017955
bleeding in the stomach and/or the intestines
gastrointestinal hemorrhage AE
MP: MP_0000465
a movement disorder AE that has an outcome of eyes gaze upward
According to the Vaccine Adverse Event Reporting System (VAERS), 'eyes gaze upward' was mentioned in 1,249 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543).
YH
eyes gaze upward AE
a nervous system AE that shows a damage to or disease affecting the nerves.
Neuropathy is often classified according to the types or location of nerves that are affected. Neuropathy can also be classified according to the disease causing it. (For example, neuropathy from the effects of diabetes is called diabetic neuropathy. Ref: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy.
YH, RR
WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm
WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy
WEB: http://www.medicalnewstoday.com/articles/147963.php
WEB: http://www.neuropathy.org/
神经病变
neuropathy AE
HPO: HP_0007141
SIDER: C0442874
a skin adverse event that has an outcome of skin nodule
According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543).
YH
skin nodule AE
HPO: HP_0200036
SIDER: C0037287
a movement disorder AE that has an outcome of arthrosis.
YH
Arthrosis is an articular illness that produces fibrosis or degeneration of the cartilage.
arthrosis AE
a muscle adverse event which has an outcome of hypokinesia, refering to slow or diminished movement of body musculature.
YH
10021021
hypokinesia AE
HPO: HP_0002375
SIDER: C0086439
Muscle twitch AE is a twitching AE that is a small, local, involuntary muscle contraction and relaxation which may be visible under the skin.
JX, YH
WEB: http://en.wikipedia.org/wiki/Fasciculation
fasciculation AE
muscle contraction AE
myokymia AE
10028346
muscle twitch AE
skin discoloration AE is a skin adverse event that results in change in color of skin or mucus membranes
According to the Vaccine Adverse Event Reporting System (VAERS), 'skin discoloration' is an adverse event that was mentioned in 909 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543).
YH, SS
skin discolouration AE
10040829
skin discoloration AE
a varicella zoster virus infection AE that occurs in adults and rarely in children.
YH
herpes zoster AE
zoster AE
WEB: http://www.mayoclinic.org/diseases-conditions/shingles/basics/causes/con-20019574
10019974
Herpes zoster is a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. The initial infection with varicella zoster virus (VZV) causes the acute (short-lived) illness chickenpox, and generally occurs in children and young people. Once an episode of chickenpox has resolved, the virus is not eliminated from the body but can go on to cause shingles (an illness with very different symptoms) often many years after the initial infection.
shingles AE
HPO: HP_0005353
SIDER: C0019360
a movement disorder AE that has an outcome of laryngismus
According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngismus' is an adverse event that was mentioned in 881 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543).
YH
laryngospasm
sudden laryngeal spasm with crowing inhalation and cyanosis
Laryngismus is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords.
laryngismus AE
a behavior and neurological AE that has an outcome of disorder in speech
YH
10041466
speech disorder AE
HPO: HP_0006977
SIDER: C0037822
a cardiovascular disorder AE that has an outcome of hemorrhage
bleeding AE
haemorrhage AE
WEB: http://medical-dictionary.thefreedictionary.com/hemorrhage
10055798
loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels
hemorrhage AE
MP: MP_0001914
a bone disorder AE which has an outcome of neck rigidity
YH
neck rigidity AE
a nervous system AE that has the symptom of GBS. Guillain-Barre syndrome (GBS) is a disorder in which the body's immune system attacks part of the peripheral nervous system. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. In many instances, the weakness and abnormal sensations spread to the arms and upper body. These symptoms can increase in intensity until the muscles cannot be used at all and the patient is almost totally paralyzed. In these cases, the disorder is life-threatening and is considered a medical emergency. Usually Guillain-Barre occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. Reference: http://www.ninds.nih.gov/disorders/gbs/gbs.htm.
YH, SS
GBS AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299621
10018767
Guillain-Barre syndrome AE
HPO: HP_0007131
SIDER: C0018378
an abnormal digestion AE which has an outcome of nausea and vomiting
According to the Vaccine Adverse Event Reporting System (VAERS), 'nausea and vomiting' is an adverse event that was mentioned in 812 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543).
This term will most likely removed since it is just a combination of nausea and vomiting.
YH
nausea and vomiting AE
a sudden death AE that occurs to an infant.
According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543).
YH
sudden infant death AE
a fever AE that has an outcome of fever with chills, which is successive stages of chills and fever. This is a symptom of malaria.
YH
chills and fever AE
10016559
fever with chills AE
a psychiatric disorder AE that is characterized by enduring maladaptive patterns of behavior, cognition, and inner experience, exhibited across many contexts and deviating markedly from those accepted by the individual's culture.
YH, MW
WEB: https://en.wikipedia.org/wiki/Personality_disorder
10034721
personality disorder AE
HPO: HP_0000751
SIDER: C0031212
a respiratory system AE which has an outcome of lung disorder
YH
lung disorder AE
10025082
lung AE
HPO: HP_0006552
SIDER: C0024115
a musculoskeletal system AE that occurs in muscle.
YH
muscle AE
an adverse event that occurs in liver, biliary, and pancreatic areas.
YH, JX
liver, biliary, and pancreatic disorder AE
URL: http://www.ijhpd.com/
WEB: http://www.uchospitals.edu/online-library/content=P00670
hepatobiliary or pancreatic AE
a liver/biliary system AE which has an outcome of an enlarged liver, or larger than average size of the liver
According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatomegaly' was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
enlarged liver AE
MP: MP_0000599
a brain inflammation AE which results in an inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation is caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs or diseases.
YH, JX
WEB: http://www.cdc.gov/meningitis/index.html
脑膜炎
10027199
meningitis AE
CTCAE: E11458
HPO: HP_0001287
NCIt: C26828
SIDER: C0025289
an AE that occurs in digestive system.
YH
digestive system AE
a paralysis AE that has an outcome of paralysis in face
According to the Vaccine Adverse Event Reporting System (VAERS), 'facial paralysis' was mentioned in 580 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543).
YH
facial paralysis AE
HPO: HP_0007209
SIDER: C0015469
a psychiatric disorder AE that has an outcome of confusion, which is a mild form of delirium.
YH, KM
confused state AE
mental confusion AE
WEB: http://medical-dictionary.thefreedictionary.com/mental+confusion
10010300
10010305
confusion AE
CTCAE: E12889
NCIt: C37928
a musculoskeletal system AE which has an outcome of joint disorder
YH
joint disorder AE
an AE that occurs in eye.
YH
eye disorder AE
10015916
eye AE
HPO: HP_0000496
SIDER: C0015397
a behavior and neurological AE that has an outcome of autism
YH
Autism is a brain development disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior.
autism AE
a hematopoietic system AE which has an outcome of sedimentation rate increased
According to the Vaccine Adverse Event Reporting System (VAERS), 'sedimentation rate increased' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
This term should be inferred to lab test abnormal.
YH
ESR
erythrocyte sedimentation rate
red blood cell sedimentation rate increased AE
sedrate
Sedimentation rate is a diagnostic test for inflammation. The test measures the rate at which red blood cells fall to the bottom of a tube over time. An increased sedimentation rate corresponds to increased non-specific inflammation in the body. It is often called "sedrate" for short.
red blood cell sedimentation rate increased AE is an AE: sedimentation rate increased that has an increase in rate at which red blood cells precipitate in a period of 1 hour.
sedimentation rate increased AE
an arthritis AE that has an outcome of arthritis due to an infection in another part of the body
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/16822921
10003267
arthritis reactive AE
an abnormal vision AE which has an outcome of amblyopia
YH
10001906
amblyopia AE
HPO: HP_0000646
SIDER: C0002418
a psychiatric disorder AE that has an outcome of mental retardation
YH
mental retardation AE
HPO: HP_0001249
SIDER: C0025362
a rash AE which shows red, target-shaped or "bulls-eye" patches or sores on the skin.
YH, MW
WEB: http://kidshealth.org/parent/infections/skin/erythema_multiforme.html
WEB: https://en.wikipedia.org/wiki/Erythema_multiforme
10015218
The erythema multiforme rash usually begins on the arms, hands, legs, and feet, but you might also find it on the face, neck, and body. It also can affect the lips and inside the mouth. It usuallys follows an infection or drug exposure.
erythema multiforme AE
CTCAE:E13627
HPO: HP_0010783
NCIt:C3024
SIDER: C0014742
a lab test abnormal AE that has an outcome of SGOT increased
According to the Vaccine Adverse Event Reporting System (VAERS), 'SGOT increased' is an adverse event that was mentioned in 477 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
YH
SGOT respresents serum glutamic oxaloacetic transaminase, an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGOT levels. SGOT is also called aspartate aminotransferase (AST).
SGOT increased AE
a lab test abnormal AE that has an outcome of SGPT increased
According to the Vaccine Adverse Event Reporting System (VAERS), 'SGPT increased' is an adverse event that was mentioned in 459 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
YH
SGPT represents serum glutamic pyruvic transaminase, an enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart are damaged. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. SGPT is also called alanine aminotransferase (ALT).
SGPT increased AE
a behavioral and neurological AE that has an outcome of thinking abnormality
According to the Vaccine Adverse Event Reporting System (VAERS), 'thinking abnormality' is an adverse event that was mentioned in 457 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
YH, JX
10043431
thinking abnormality AE
an abnormal digestion AE which has an outcome of dyspepsia
According to the Vaccine Adverse Event Reporting System (VAERS), 'dyspepsia' is an adverse event that was mentioned in 454 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
YH
10013946
Dyspepsia is popularly known as indigestion, meaning hard or difficult digestion. It is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating.
dyspepsia AE
HPO: HP_0002577
SIDER: C0013395
an allergy AE which has an outcome of anaphylactoid reaction AE is an acute systemic (multi-system) and very severe Type I Hypersensitivity allergic reaction in humans and other mammals. Minute amounts of allergens may cause a life-threatening anaphylactic reaction.
According to the Vaccine Adverse Event Reporting System (VAERS), 'anaphylactoid reaction' was mentioned in 452 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22293078
10002198
10002216
anaphylactoid reaction AE
HPO: HP_0100845
SIDER: C0340865
a digestive system AE which has an outcome of a gastrointestinal disorder
According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
YH
gastrointestinal disorder AE
HPO: HP_0011024
SIDER: C0017178
an edema AE that has an outcome of accumulation of fluid in the peritoneal cavity
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23296107
10003445
ascites AE
CTCAE: E10502
HPO: HP_0001541
NCIt: C2885
SIDER: C0003962
a hypersensitivity AE which has an outcome of serum sickness
According to the Vaccine Adverse Event Reporting System (VAERS), 'serum sickness' is an adverse event that was mentioned in 428 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
YH, MW
10040400
Serum sickness is a reaction to proteins in antiserum derived from an animal source. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III).
serum sickness AE
CTCAE: E11276
NCIt: C79718
an abscess AE which has an outcome of injection-site abscess
YH
injection-site abscess AE
a neurological, special senses and psychiatric investigation result abnormal AE that is the abnormal result of a procedure that uses small, flat metal discs (electrodes) attached to your scalp to detect electrical activity in your brain
According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal electroencephalogram' is an adverse event that was mentioned in 420 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
YH, EB
WEB: http://www.mayoclinic.com/health/eeg/MY00296
10000130
abnormal electroencephalogram result AE
a dizziness AE that has an outcome of vertigo
According to the Vaccine Adverse Event Reporting System (VAERS), 'vertigo' was mentioned in 412 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
YH
10047340
Vertigo is a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is actually stationary with respect to the surroundings. The effects of vertigo may be slight. It can cause nausea and vomiting and, in severe cases, it may give rise to difficulties with standing and walking.
vertigo AE
CTCAE: E10291
HPO: HP_0002321
NCIt: C38057
SIDER: C0042571
a cardiac disorder AE that has an outcome of heartarrest, the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during systole.
YH
cardiopulmonary arrest
circulatory arrest
heart arrest AE
WEB: http://en.wikipedia.org/wiki/Myocardial_infarction
WEB: http://medical-dictionary.thefreedictionary.com/cardiac+arrest
10007515
10007617
10028596
cardiac arrest
CTCAE: E10101
NCIT: C50479
a respiratory system inflammation AE which has an outcome of bronchitis
YH
Bronchitis is an inflammation of the air passages within the lungs. It occurs when the trachea (windpipe) and the large and small bronchi (airways) within the lungs become inflamed because of infection or other causes.
bronchitis AE
HPO: HP_0002837
SIDER: C0006277
a seizure AE that has an outcome of grand malconvulsion
YH
A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process).
grand malconvulsion AE
a liver related investigation result abnormal AE which shows an abnormal test result in a liver function test, indicating aberrant function of liver.
According to the Vaccine Adverse Event Reporting System (VAERS), 'liver function tests abnormal' was mentioned in 717 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543).
WEB: http://medical-dictionary.thefreedictionary.com/hepatic+function
10019670
10024690
liver function test abnormal AE
MP: MP_0000609
an AE that occurs in ear.
YH
ear disorder AE
ear AE
HPO: HP_0000598
SIDER: C0013447
an infection AE that results in detrimental colonization of a host organism by virus
YH, SS
viral infection
WEB: http://en.wikipedia.org/wiki/Viral_infection
viral infection AE
HPO: HP_0005364
SIDER: C0042769
a movement disorder AE that has an outcome of lacrimation disorder
According to the Vaccine Adverse Event Reporting System (VAERS), 'lacrimation disorder' was mentioned in 334 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
YH
Lacrimation is the production, secretion, and shedding of tears.
lacrimation disorder AE
a liver/biliary system AE which has an outcome of jaundice, which is the clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes
According to the Vaccine Adverse Event Reporting System (VAERS), 'jaundice' is an adverse event that was mentioned in 317 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
SS, YH
icterus AE
WEB: http://en.wikipedia.org/wiki/Jaundice
10023126
jaundice AE
HPO: HP_0000952
MP: MP_0000611
SIDER: C0022346
an immune system disorder AE which shows an enclosed collection of liquefied tissue, known as pus, somewhere in the body. Abscess is the result of the body's defensive reaction to foreign material.
YH
abscessus
WEB: http://medical-dictionary.thefreedictionary.com/abscess
10000269
An abscess is a collection of pus (dead neutrophils) that has accumulated in a cavity formed by the tissue on the basis of an infectious process (usually caused by bacteria or parasites) or other foreign materials (e.g. splinters, bullet wounds, or injecting needles). It is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body.
abscess AE
HPO: HP_0002722
SIDER: C0000833
a pain AE that has an outcome of eye pain
According to the Vaccine Adverse Event Reporting System (VAERS), 'eye pain' is an adverse event that was mentioned in 316 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH
10015958
eye pain AE
CTCAE: E10376
HPO: HP_0200025
NCIt: C78287
SIDER: C0151827
a sensory capability AE that has an outcome of palpitation
YH
WEB: http://en.wikipedia.org/wiki/Palpitations
10033557
A palpitation is an abnormal awareness of the beating of the heart, whether it is too slow, too fast, irregular, or at its normal frequency.
palpitation AE
an edema AE which has an outcome of tongue edema
YH, RR
tongue oedema AE
tongue swelling AE
WEB: http://www.medterms.com/script/main/art.asp?articlekey=97582
10042727
tongue edema AE
a pain AE that has an outcome of ear pain
According to the Vaccine Adverse Event Reporting System (VAERS), 'ear pain' was mentioned in 302 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH
10014020
ear pain AE
CTCAE: E10262
HPO: HP_0010833
NCIt: C37944
SIDER: C0013456
an edema AE which has an outcome of angioedema
YH, SJ
angioneurotic edema
WEB: http://www.mayoclinic.org/diseases-conditions/hives-and-angioedema/basics/definition/con-20014815
10002473
Angioedema is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues often around the eyes and lips. It is very similar to urticaria, but urticaria, commonly known as hives, occurs in the upper dermis.
angioedema AE
An arthritis AE that has the outcome of rheumatoid arthritis. Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body.
YH
rheumatoid arthritis AE
HPO: HP_0005681
SIDER: C0003873
an AE that occurs in immune system.
According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder' was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH
immune system disorder AE
immune system AE
HPO: HP_0002715
SIDER: C0021053
an immune system disorder AE which has an outcome of antinuclear antibody present
According to the Vaccine Adverse Event Reporting System (VAERS), 'antinuclear antibody present'; is an adverse event that was mentioned in 288 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH
anti-nuclear factor present
The presence of anti-nuclear antibodies (ANAs) that are antibodies directed against contents of the cell nucleus. ANAs are present in higher than normal numbers in autoimmune disease. The ANA test measures the pattern and amount of autoantibody which can attack the body's tissues as if they were foreign material. Autoantibodies are present in low titers in the general population, but in about 5% of the population, their concentration is increased, and about half of this 5% have an autoimmune disease.
antinuclear antibody present AE
a nervous system AE which involves inflammation of the spinal cord, which disrupts central nervous system functions linking the brain and limbs.
YH, MW
10028524
myelitis AE
CTCAE: E12732
NCIt: C26832
a headache AE that has an outcome of migraine
According to the Vaccine Adverse Event Reporting System (VAERS), 'migraine'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH
migraine headache
A migraine is a very painful type of headache. People who get migraines often describe the pain as pulsing or throbbing in one area of the head. During migraines, people are very sensitive to light and sound. They may also become nauseated and vomit.
migraine AE
HPO: HP_0002076
SIDER: C0149931
Thrombocytopenic purpura AE are purpura AE associated with a reduction in circulating blood platelets which can result from a variety of causes.
According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocytopenic purpura'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH
10043561
thrombocytopenic purpura AE
HPO: HP_0004829
SIDER: C0857305
multiple sclerosis AE is an immune system disorder AE, or an autoimmune condition in which the immune system attacks the central nervous system, leading to demyelination.
YH
MS
disseminated sclerosis
encephalomyelitis disseminata
10028245
multiple sclerosis AE
a behavior and neurological AE that has an outcome of amnesia in a patient
YH, MW
10001949
Amnesia is a short term memory condition in which memory is disturbed. In simple terms it is the loss of memory.
amnesia AE
CTCAE:E12585
HPO: HP_0002354
NCIt:C2867
SIDER: C0002622
a movement disorder AE that has an outcome of incoordination
According to the Vaccine Adverse Event Reporting System (VAERS), 'incoordination' was mentioned in 261 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH
a lack of normal adjustment of muscular action so that the intended movement of the limb or other part is not made smoothly and harmoniously, and does not accurately achieve its objective. If the abnormality is hypermetric, the condition is referred to as ataxia. If it is inclined to weakness, e.g. knuckling at the turn, stumbling, failure to flex limbs properly, or to misdirection as in a proprioceptive deficit, it is called incoordination.
incoordination AE
a speech disorder that has an outcome of voice alteration
YH, MW
10047681
voice alteration AE
CTCAE: E13601
NCIt: C61043
a pregnancy AE that is the termination of a pregnancyby the removal or expulsion from the uterus of a fetus or embryo, resulting in or caused by its death.
According to the Vaccine Adverse Event Reporting System (VAERS), 'abortion'; is an adverse event that was mentioned in 257 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH, SS
WEB: http://en.wikipedia.org/wiki/Abortion
10000210
abortion AE
a psychiatric disorder AE that has an outcome of shock
YH
acute stress disorder AE
acute stress reaction AE
mental shock AE
10001084
Mental shock (or shock) is a psychological condition arising in response to a terrifying event. It should not be confused with the unrelated circulatory condition of shock.
There are two types of shocks. Another is circulatory shock which is physiological with MedDRA ID of 10040560.
psychological shock AE
a skin discoloration AE which has an outcome of purpura
According to the Vaccine Adverse Event Reporting System (VAERS), 'purpura'; is an adverse event that was mentioned in 251 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH, MW
紫癜
10037549
Purpura is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This is common with typhus and can be present with meningitis caused by meningococcal meningitis or septicaemia. Reference: http://en.wikipedia.org/wiki/Purpura.
purpura AE
CTCAE:E13690
HPO: HP_0000979
NCIt:C78787
SIDER: C0034150
an infection AE that results in detrimental colonization of a host organism by bacteria
YH, SS
bacterial infection AE
WEB: http://en.wikipedia.org/wiki/Bacterial_infection
10060945
bacterial infection AE
HPO: HP_0002718
SIDER: C0004623
a skin adverse event that has an outcome of skin striae that displays irregular areas of skin that look like bands, stripes, or lines. Striae are seen when a person grows or gains weight rapidly or has certain diseases or conditions.
According to the Vaccine Adverse Event Reporting System (VAERS), 'skin striae'; is an adverse event that was mentioned in 247 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH
stretch marks
striae distensae
skin striae AE
HPO: HP_0001065
SIDER: C0152459
a syndrome AE that has an outcome of an acute brain syndrome AE and occurs after a medical intervention.
YH
acute brain syndrome AE
a sensory capability AE that has an outcome of coma
YH
10010071
Coma is a profound state of unconsciousness. A comatose person cannot be awakened, fails to respond normally to pain or light, does not have sleep-wake cycles, and does not take voluntary actions.
coma AE
HPO: HP_0001259
SIDER: C0009421
a muscle adverse event which has an outcome of hyperkinesia, an abnormal increase in muscular activity.
YH
10020651
hyperkinesia AE
HPO: HP_0002487
SIDER: C0424295
an AE that occurs in cardiovascular system.
YH
cardiovascular disorder AE
10007649
cardiovascular AE
HPO: HP_0001626
SIDER: C0007222
a nervous system AE which has an outcome of encephalopathy, which is disorder or disease of the brain.
YH, MW
10014625
encephalopathy AE
CTCAE:E12652
HPO: HP_0007239
NCIt:C26920
SIDER: C0085584
a urinary system AE that has an outcome of urine abnormality AE
YH
urine abnormality AE
HPO: HP_0011036
SIDER: C0235639
a gastrointestinal disorder AE which has an outcome of gastroenteritis, an inflammation occuring in the gastrointestinal tract that involves both the stomach and the small intestine, often results in diarrhea, vomiting and abdominal pain and cramping
According to the Vaccine Adverse Event Reporting System (VAERS), 'gastroenteritis' was mentioned in 218 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
YH
WEB: http://medical-dictionary.thefreedictionary.com/gastroenteritis
10017888
gastroenteritis AE
HPO: HP_0004386
SIDER: C0017160
a cardiovascular disorder AE that has an outcome of peripheral vascular disorder
YH
peripheral vascular disorder AE
HPO: HP_0005299
SIDER: C0085096
a urinary system AE that has an outcome of urnary tract infection AE
YH
10046571
urinary tract infection AE
CTCAE: E11614
HPO: HP_0000094
NCIt: C50791
SIDER: C0042029
an abnormal salivary gland physiology AE which has an outcome of increased salivation, meaning greater than normal amounts of flowing saliva
According to the Vaccine Adverse Event Reporting System (VAERS), 'increased salivation' is an adverse event that was mentioned in 336 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
increased salivation AE
MP: MP_0000622
a psychiatric disorder AE that has an outcome of depression. Depression causes a persistent feeling of sadness and loss of interest.
YH, MW
WEB: http://www.mayoclinic.org/diseases-conditions/depression/basics/definition/con-20032977
10012378
depression AE
CTCAE:E12909
HPO: HP_0000716
NCIt:C2982
SIDER: C0011570
a glucose homeostasis AE which has an outcome of diabetes mellitus
YH
diabetes AE
10012601
Diabetes mellitus, often referred to simply as diabetes, is a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormally high blood sugar levels (hyperglycemia).
diabetes mellitus AE
HPO: HP_0000819
SIDER: C0011849
a respiratory system inflammation AE which has an outcome of laryngitis
According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngitis'; is an adverse event that was mentioned in 190 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
10023874
Laryngitis is an inflammation of the larynx. It causes hoarse voice or the complete loss of the voice because of irritation to the vocal folds (vocal cords).
laryngitis AE
CTCAE: E11435
HPO: HP_0001600
NCIt: C26811
SIDER: C0023067
a muscle spasm AE which has an outcome of generalized spasm, which is an involuntary contraction of a muscle or group of muscles. Spasms may involve skeletal muscle (MUSCLE, SKELETAL) or smooth muscle (MUSCLE, SMOOTH).
YH
generalized spasm AE
According to the Vaccine Adverse Event Reporting System (VAERS), 'reflexes decreased'; is an adverse event that was mentioned in 178 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
hyporeflexia AE
a movement disorder AE that has an outcome of reflexes decreased, an abnormal decrease in an involuntary response to a peripheral stimulus
reflexes decreased AE
a digestive system AE which has an outcome of dry mouth, which is dryness of the mouth resulting from reduced salivary secretion
According to the Vaccine Adverse Event Reporting System (VAERS), 'dry mouth'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
xerostomia
10013781
dry mouth AE
CTCAE: E10578
HPO: HP_0000217
NCIt: C26917
SIDER: C0043352
a neuritis AE which has an outcome of optic neuritis
YH
10030942
optic neuritis AE
HPO: HP_0100653
SIDER: C0029134
a cardiovascular disorder AE that has an outcome of thrombocythemia
YH
Thrombocythemia (primary thrombocythemia) is a disorder in which excess platelets are produced, leading to abnormal blood clotting or bleeding.
thrombocythemia AE
a hemorrhage AE that has an outcome of epistaxis
YH, MW
nosebleed
10015090
Epistaxis is the relatively common occurrence of hemorrhage from the nose, usually noticed when the blood drains out through the nostrils.
epistaxis AE
CTCAE:E13374
HPO: HP_0000421
NCIt:C26766
SIDER: C0014591
a syndrome AE that displays a lupus syndrome. Lupus is an autoimmune disease where the body's immune system becomes hyperactive and attacks normal, healthy tissue. This results in symptoms such as inflammation, swelling, and damage to joints, skin, kidneys, blood, the heart, and lungs.
YH, JX
lupus syndrome AE
狼疮样综合征
WEB: http://www.medicalnewstoday.com/info/lupus/
lupus AE
an eye disorder AE which has an outcome of photophobia
YH
10034960
Photophobia is a symptom of excessive sensitivity to light and the aversion to sunlight or well-lit places. In medical terms it is not fear, but an experience of discomfort or pain to the eyes due to light exposure.
photophobia AE
CTCAE: E10416
HPO: HP_0000613
NCIt: C28210
SIDER: C0085636
a digestive system AE which has an outcome of abnormal salivary gland physiology, which is any functional anomaly of any of the glands in the mouth that secrete saliva
abnormal salivary gland physiology AE
MP: MP_0005310
a psychiatric disorder AE that has an outcome of hallucination
YH, MW
hallucinations AE
10019063
10019077
A hallucination, in the broadest sense, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space.
hallucination AE
CTCAE: E12919
HPO: HP_0000738
NCIt: C37961
SIDER: C0018524
a digestive system AE which has an outcome of tongue disorder
According to the Vaccine Adverse Event Reporting System (VAERS), 'tongue disorder'; is an adverse event that was mentioned in 156 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
tongue disorder
HPO: HP_0000157
SIDER: C0040409
a pain AE that has an outcome of neuralgia
According to the Vaccine Adverse Event Reporting System (VAERS), 'neuralgia'; is an adverse event that was mentioned in 155 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
YH, MW
10029223
Neuralgia or neuropathic pain can be defined most simply as non-nociceptive pain. Neuralgia is pain produced by a change in neurological structure or function. Unlike nociceptive pain, Neuralgia exists with no continuous nociceptive input. Neuralgia falls into two categories: central Neuralgia and peripheral Neuralgia.
neuralgia AE
CTCAE:E12744
HPO: HP_0003489
NCIt:C79695
SIDER: C0027796
an edema AE which has an outcome of lung edema
YH
lung edema AE
a paresthesia AE that occurs around the mouth.
YH
circumoral paresthesia AE
HPO: HP_0003401
SIDER: C0151838
an abnormal fluid regulation AE which has an outcome of thirst
YH
10043458
Thirst is the craving for liquids, resulting in the basic instinct of humans or animals to drink. It is an essential mechanism involved in fluid balance.
thirst AE
HPO: HP_0001959
SIDER: C0039971
a musculoskeletal system AE that occurs in the bone
YH
bone disorder
10005956
bone AE
HPO: HP_0000924
SIDER: C0005940
a perinatal AE that displays fetal disorder.
YH
fetal disorder AE
a sensory capability AE that has an outcome of emotional liability
YH
emotional liability AE
a muscle adverse event which has an outcome of muscle spasm, which is an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions
SS, YH
WEB: http://en.wikipedia.org/wiki/Spasm
10028334
muscle spasm AE
MP: MP_0000743
a connective tissue disorder AE that occurs at the location of tendon
A tendon (or sinew) is a tough band of fibrous connective tissue that usually connects muscle to bone and is capable of withstanding tension.
According to the Vaccine Adverse Event Reporting System (VAERS), 'tendon disorder'; is an adverse event that was mentioned in 137 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
Tendon disorder is a medical condition that results in a tendon not functioning normally.
tendon disorder AE
a behavior and neurological AE that has an outcome of hostility
YH
10020400
hostility AE
an eye disorder AE which has an outcome of visual field defect
SS, YH
visual impairment AE
WEB: http://en.wikipedia.org/wiki/Visual_impairment
10047555
10047571
visual field defect AE
a muscle adverse event which has an outcome of myopathy AE, an abnormal condition or disease of the skeletal muscle
10028641
myopathy AE
HPO: HP_0003198
MP: MP_0000751
SIDER: C0026848
a behavior and neurological AE that has an outcome of apathy state
YH
impassivity
perfunctoriness
10002942
Apathy is a state of indifference, or the suppression of emotions such as concern, excitement, motivation and passion. An apathetic individual has an absence of interest or concern to emotional, social, or physical life. They may also exhibit an insensibility or sluggishness.
apathy AE
HPO: HP_0000741
SIDER: C0085632
a paralysis AE that has an outcome of hemiplegia
According to the Vaccine Adverse Event Reporting System (VAERS), 'hemiplegia'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
10019468
Hemiplegia is total paralysis of the arm, leg, and trunk on the same side of the body. Hemiplegia is more severe than hemiparesis, wherein one half of the body is weakened but not paralysed.
hemiplegia AE
HPO: HP_0002301
SIDER: C0018991
a rash AE that is characterized by a circumscribed and elevated skin lesion filled with pus.
According to the Vaccine Adverse Event Reporting System (VAERS), 'pustular rash'; is an adverse event that was mentioned in 128 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
rash pustular AE
10037888
pustular rash AE
CTCAE: E11545
NCIt: C80119
a blood creatine phosphokinase level abnormal AE that is characterized by an increased level of creatine phosphokinase (CPK) or phosphocreatine kinase, an enzyme expressed by various tissue types that catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP)
YH, EB
elevated serum creatine phosphate kinase AE
10005470
blood creatine phosphokinase level increased AE
a hypertension AE that has an outcome of elevated pressure in the skull.
YH, SS
WEB: http://www.ihrfoundation.org/intracranial/hypertension/info/C16
10049977
intracranial hypertension AE
a sensory neuropathy AE which shows a painful neuropathy characterized by damage to sensory and motor nerves
AG, YH
sensorimotor painful neuropathy AE
a digestive system AE which has an outcome of abnormal stool
According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal stools' was mentioned in 111 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
abnormal stool AE
a pain AE that has an outcome of bone pain
According to the Vaccine Adverse Event Reporting System (VAERS), 'bone pain' was mentioned in 109 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
YH, MW
10006002
bone pain AE
CTCAE:E12392
HPO: HP_0002653
NCIt:C38644
SIDER: C0151825
a cardiovascular disorder AE that comes with cerebrovascular accident
YH
stroke
10008190
Cerebrovascular accident: The sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A CVA is also referred to as a stroke.
cerebrovascular accident AE
HPO: HP_0001297
SIDER: C0038454
a digestive system AE which has an outcome of parotid gland enlargement
According to the Vaccine Adverse Event Reporting System (VAERS), 'parotid gland enlargement' was mentioned in 103 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
10034023
parotid gland enlargement AE
a movement disorder AE that has an outcome of flatulence
According to the Vaccine Adverse Event Reporting System (VAERS), 'flatulence' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
10016766
Flatulence is the production of a mixture of gases in the digestive tract of mammals or other animals that are byproducts of the digestion process. Such a mixture of gases is known as flatus, and is expelled from the rectum in a process colloquially referred to as "passing gas" or "farting".
flatulence AE
CTCAE: E10697
HPO: HP_0011024
NCIt: C37954
SIDER: C0016204
a liver/biliary system AE which has an outcome of liver damage
According to the Vaccine Adverse Event Reporting System (VAERS), 'liver damage' was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543).
YH
liver damage AE
a respiratory system AE which has an outcome of sore throat
YH, MW
10041367
sore throat AE
CTCAE: E13575
NCIt: C50747
a movement disorder AE that results in the loss of power of voluntary movement in a muscle through injury or disease of its nerve supply
According to the Vaccine Adverse Event Reporting System (VAERS), 'paralysis' is an adverse event that was mentioned in 574 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
SS, YH
WEB: https://www.nlm.nih.gov/medlineplus/paralysis.html
瘫痪
10033799
paralysis AE
HPO: HP_0010549
MP: MP_0000753
SIDER: C0522224
a bone disorder AE that has an outcome of cellular death of bone components due to interupption of blood supply
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/avascular+necrosis
10003460
aseptic necrosis bone AE
a physical examination result abnormal AE that has an outcome of weight loss, which is the progressive reduction of body weight below normal average for age
MW, YH
weight decreased AE
10047895
10047900
weight loss AE
CTCAE: E12228
MP: MP_0001263
NCIt: C3445
According to the Vaccine Adverse Event Reporting System (VAERS), 'ataxia' is an adverse event that was mentioned in 555 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
YH, MW
10003591
a movement disorder AE that has an outcome of ataxia, inability to coordinate voluntary muscular movements
ataxia AE
CTCAE:E12597
HPO: HP_0001251
MP: MP_0001393
NCIt:C26702
SIDER: C0004134
a hair, skin, and nail AE that occurs in skin.
YH
WEB: http://www.thefreedictionary.com/skin+disorder
10040831
skin AE
a movement disorder AE that has an outcome of unusual or distinctive way of walking
According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal gait' is an adverse event that was mentioned in 998 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543).
SS, YH
gait disturbance AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21224774
10017577
abnormal gait AE
CTCAE: E11112
MP: MP_0001406
NCIt: C78303
an abnormal fluid regulation AE which has an outcome of dehydration, which is an excessive water loss from the body or from an organ or bodily part
YH, SS, MW
hypohydration
10012174
dehydration AE
CTCAE:E12258
HPO: HP_0001944
MP: MP_0001429
NCIt:C26740
SIDER: C0011175
a homeostasis AE which has an outcome of abnormal fluid regulation, which is any anomaly in the control of intracellular and/or extracellular fluid
abnormal fluid regulation AE
MP: MP_0001784
a glucose homeostasis AE which has an outcome of hyperglycemia, which is an abnormally high concentration of glucose in the blood; generally refers to a pathological state
YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/hyperglycemia
10020635
10020639
hyperglycemia AE
CTCAE: E12276
MP: MP_0001559
NCIt: C26797
a homeostasis AE which has an outcome of abnormal ciculating bilirubin level, which is aberrant concentration in the blood of this yellow heme breakdown product
According to the Vaccine Adverse Event Reporting System (VAERS), 'bilirubinemia'; is an adverse event that was mentioned in 221 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
abnormal circulating bilirubin level AE
MP: MP_0001569
a skin adverse event that has an outcome of cyanosis, a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood
According to the Vaccine Adverse Event Reporting System (VAERS), 'cyanosis' is an adverse event that was mentioned in 1,804 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543).
10011703
cyanosis AE
HPO: HP_0000961
MP: MP_0001575
SIDER: C0010520
a hematopoietic system AE which has an outcome of anemia, which is less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs
anaemia AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001586/
10002034
10002272
anemia AE
CTCAE: E10010
MP: MP_0001577
NCIt: C2869
an abnormal blood pressure AE that has an outcome of sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states
YH, MW
blood pressure decreased, low blood pressure
10005734
10021097
hypotension AE
CTCAE: E13791
HPO: HP_0002615
MP: MP_0001596
NCIt: C3128
SIDER: C0020649
an arrhythmia AE that has an outcome of uneven timing of heart contraction
irregular heartbeat AE
MP: MP_0001636
an electrolyte lab test abnormal AE that shows an abnormal level of an electrolyte in the blood
YH, MW
electrolyte blood test abnormal AE
a digestive system AE which has an outcome of abnormal digestion, which is an altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy
abnormal digestion AE
MP: MP_0001664
an AE that occurs in the homeostasis system.
anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues
homeostasis AE
MP: MP_0001764
an abnormal fluid regulation AE which has an outcome of edema, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues
oedema, swelling, dropsy
WEB: http://en.wikipedia.org/wiki/Oedema
WEB: http://en.wikipedia.org/wiki/Swelling_(medical)
10016807
10030095
10042674
edema AE
MP: MP_0001785
an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult.
SS, YH
WEB: http://en.wikipedia.org/wiki/Inflammation
10061218
inflammation AE
HPO: HP_0007891
MP: MP_0001846
SIDER: C0021368
an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain
According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
brain inflammation AE
MP: MP_0001847
an ear disorder AE which has an outcome of increased susceptibility to otitis media, which is greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection
increased susceptibility to otitis media AE
MP: MP_0001850
an eye disorder AE which has an outcome of eye inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the eye
10015943
eye inflammation AE
HPO: HP_0100533
MP: MP_0001851
SIDER: C0239429
an eye inflammation AE which has an outcome of conjunctivitis, which is inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball
10010741
conjunctivitis AE
CTCAE: E10355
HPO: HP_0000509
MP: MP_0001852
NCIt: C34504
SIDER: C0009763
an inflammation AE that shows a local accumulation of fluid, plasma proteins, and leukocytes in the liver
According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatitis' was mentioned in 387 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
YH, JX
liver inflammation AE
MP: MP_0001860
aa inflammation AE which has an outcome of lung inflammation, a local accumulation of fluid, plasma proteins, and leukocytes in the lung
According to the Vaccine Adverse Event Reporting System (VAERS), 'pneumonia' was mentioned in 879 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543).
lung inflammation AE
MP: MP_0001861
an inflammation AE which occurs in the respiratory system, which is reflected with the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system
respiratory system inflammation AE
MP: MP_0002405
an inflammation AE that has an outcome of vasculitis, which is an inflammation of a blood or lymph vessel
It's an inflammation.
YH, MW
10047115
vasculitis AE
CTCAE:E13837
HPO: HP_0002633
MP: MP_0001864
NCIt:C26912
SIDER: C0042384
an inflammation AE which has an outcome of salivary gland inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland
salivary gland inflammation AE
MP: MP_0001870
a respiratory system inflammation AE which has an outcome of sinus inflammation, an inflammation of paranasal sinuses, which may be due to infection, allergy, or autoimmune issues.
According to the Vaccine Adverse Event Reporting System (VAERS), 'sinusitis'; is an adverse event that was mentioned in 298 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
SS, YH, RR
sinus inflammation AE
WEB: http://en.wikipedia.org/wiki/Sinusitis
10040753
sinusitis AE
CTCAE: E11563
HPO: HP_0000246
MP: MP_0001872
NCIt: C35024
SIDER: C0037199
a hypersensitivity AE which results in an allergic response showing a marked increase in reactivity to an antigen upon subsequent exposure.
JX, LW, YH
allergic reaction AE
allergic response AE
anaphylactic reaction AE
WEB: http://en.wikipedia.org/wiki/Allergy
变态反应
过敏反应
10001718
10001738
allergy AE
CTCAE: E11248
MP: MP_0001878
NCIt: C3114
a nervous system AE which has an outcome of abnormal cerebrospinal fluid production, an anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord
abnormal cerebrospinal fluid production AE
MP: MP_0001911
an AE that occurs in nervous system.
KY, YH
nervous system disorder AE
URL: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/overview_of_nervous_system_disorders_85,P00799/
10029202
nervous system AE
MP: MP_0003633
a respiratory system AE which has an outcome of abnormal respiration, an anomaly in the movement of gases into and out of the lung
According to the Vaccine Adverse Event Reporting System (VAERS), 'respiratory disorder' is an adverse event that was mentioned in 556 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
Not sure if it is same as respiratory system disorder or abnormal respiration. --Oliver He
abnormal respiration AE
MP: MP_0001943
an abnormal respiration AE which has an outcome of apnea, temporary cessation of breathing; sometimes episodic
According to the Vaccine Adverse Event Reporting System (VAERS), 'apnea' is an adverse event that was mentioned in 1,618 VAERS reports (1.3%) during1991-2001 (Reference: PMID: 12825543).
JX, YH, MW
MedDRA: 10002974 is for "apnoea"; MedDRA: 10002972 is for "apnea".
apnoea AE
respiratory arrest AE
WEB: http://medical-dictionary.thefreedictionary.com/apnea
apnea AE
CTCAE: E13306
MP: MP_0001957
NCIt: C26698
UMLS CUI: C0003578
an ear disorder AE which has an outcome of deafness, which is an inability to hear
10011878
deafness AE
HPO: HP_0000365
MP: MP_0001967
SIDER: C0011053
an adverse event that occurs in a gustatory system
YH, JX
gustatory system AE
MP: MP_0001985
a gustatory system AE which has an outcome of taste sensitivity, or changes in the ability to perceive a particular flavor or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system
taste sensitivity AE
MP: MP_0001986
a urinary system AE that has an outcome of excessive or abnormally large production or passage of urine.
LW, ML, JX, YH
WEB: http://en.wikipedia.org/wiki/Polyuria
多尿
10036142
polyuria AE
an abnormal vision AE which has an outcome of blindness, which is loss of the sense of sight
10005169
blindness AE
HPO: HP_0000618
MP: MP_0002001
SIDER: C0456909
an eye disorder AE which has an outcome of abnormal vision, which is an inability or decreased ability to see
abnormal vision AE
MP: MP_0002090
a behavior and neurological AE that shows a sudden surge of electrical activity in the brain.
YH, JX, YH
WEB: http://www.healthline.com/symptom/seizures
突然发作
10039906
10039910
seizure AE
CTCAE: E12804
MP: MP_0002064
NCIt: C2962
an adverse event that has an outcome of an abnormal behavior and neurological phenotype.
YH, JX
behavior AE
behavioral AE
behavioral disorder AE
disruptive behavioral disorder AE
WEB: http://www.psychguides.com/guides/behavioral-disorder-symptoms-causes-and-effects/
any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls
behavioral and neurological AE
MP: MP_0004924
a behavior and neurological AE that has an outcome of altered ability to coordinate voluntary movement or repetitive, compulsive movements
10028035
movement disorder AE
HPO: HP_0100022
MP: MP_0002066
SIDER: C0026650
a behavior and neurological AE that has an outcome of inability or altered ability to respond to a sensory stimulus
sensory capability AE
MP: MP_0002067
a homeostasis AE which has an outcome of glucose homeostasis, which is an anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues
glucose homeostasis AE
MP: MP_0002078
Hypersensitivity AE is a immune system AE that is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. These reactions may be damaging, uncomfortable, or occasionally fatal.
JX, LW, YH
hypersensitivity reaction AE
WEB: http://en.wikipedia.org/wiki/Hypersensitivity
超敏反应
10020751
hypersensitivity AE
HPO: HP_0100326
MP: MP_0002148
SIDER: C0020517
YH
Muscle atrophy is a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation.
a muscle adverse event AE which has an outcome of muscular atrophy.
muscular atrophy AE
MP: MP_0002269
an abnormal respiration AE which has an outcome of hyperventilation, i.e., increased alveolar ventilation relative to metabolic carbon dioxide production; results in carbon dioxide pressure decreasing below normal
According to the Vaccine Adverse Event Reporting System (VAERS), 'Petechiae' was mentioned in 510 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
10020910
hyperventilation AE
HPO: HP_0002883
MP: MP_0002320
SIDER: C0020578
an abnormal respiration AE which has an outcome of hypoventilation, i.e., reduced alveolar ventilation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal
According to the Vaccine Adverse Event Reporting System (VAERS), 'hypoventilation' is an adverse event that was mentioned in 321 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
QL, YH
WEB: https://en.wikipedia.org/wiki/Hypoventilation
呼吸抑制
10021133
10038678
hypoventilation AE
HPO: HP_0007110
MP: MP_0002321
SIDER: C0398353
an adverse event which occurs in a hematopoietic system, which is any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells
hematopoietic system AE
MP: MP_0002396
an eye disorder AE which has an outcome of mydriasis, which is dilation of one or both pupils regardless of light conditions
10028521
mydriasis AE
HPO: HP_0011499
MP: MP_0002546
SIDER: C0026961
an arrhythmia AE that has an outcome of greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
tachycardia
WEB: http://en.wikipedia.org/wiki/Tachycardia
10019303
increased heart rate AE
MP: MP_0002626
a behavior and neurological AE that has an outcome of exaggerated reflex action
hyperresponsive to tactile stimuli AE
MP: MP_0002738
a muscle spasm AE that has an outcome of opisthotonus
YH
10030899
opisthotonus is a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward
opisthotonus AE
HPO: HP_0002179
MP: MP_0002880
SIDER: C0151818
An joint disorder AE that has an outcome of joint inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the joints
YH
joint inflammation AE
MP: MP_0002933
an abnormal enzyme level AE which has an outcome of incraesed lactate dehydrogenase level, which is greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate
increased lactate dehydrogenase level AE
MP: MP_0002944
an abnormal enzyme level AE which has an outcome of increased circulating alkaline phophatase level, which is an elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood
increased circulating alkaline phosphatase level AE
MP: MP_0002968
A joint inflammation AE that has an outcome of arthritis, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures
YH, MW
关节炎
10003246
arthritis AE
CTCAE:E12378
HPO: HP_0001369
MP: MP_0002993
NCIt:C2883
SIDER: C0003864
a digestive system AE which has an outcome of dysphagia, which is a behavior and neurological AE that has an outcome of difficulty in swallowing food or liquid
10013950
dysphagia AE
CTCAE: E10621
HPO: HP_0002015
MP: MP_0003158
NCIt: C2980
SIDER: C0011168
an ear disorder AE which has an outcome of decreased lateral semicircular canal size, which is small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance
decreased lateral semicircular canal size AE
MP: MP_0003162
a hematopoietic system AE which has an outcome of decreased platelet count, which is fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation
SS, YH
decreased platelet cell number AE
10035528
platelet count decreased AE
CTCAE: E12207
HPO: HP_0001873
MP: MP_0003179
NCIt: C3408
SIDER: C0392386
an abnormal digestion AE which has an outcome of nausea, a gastric discomfort associated with the inclination to vomit
10028813
nausea AE
HPO: HP_0002018
MP: MP_0003259; MDR: 10028813
SIDER: C0027497
regurgitation AE
10047700
an abnormal digestion AE which has an outcome of vomiting, the retrograde expulsion of gastric contents through the oral cavity
vomiting AE
CTCAE: E11068
HPO: HP_0002013
MP: MP_0003260; MDR: 10047700
NCIt: C3442
SIDER: C0042963
an abnormal defecation AE that has an outcome of constipation, which is incomplete, infrequent or difficult evacuation of fecal matter
According to the Vaccine Adverse Event Reporting System (VAERS), 'constipation'; is an adverse event that was mentioned in 242 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
infrequent bowel movements AE
10010774
constipation AE
CTCAE: E10562
HPO: HP_0002019
MP: MP_0003267
NCIt: C37930
SIDER: C0009806
a digestive system AE that has an outcome of abnormal defecation, an anomaly in the production and excretion of feces
abnormal defecation AE
MP: MP_0003866
a urinary system AE that has an outcome of the symptom of urinary incontinence, which is the inability to control the urinary excretory functions.
YH, MW
MedDRA: 10046543
WEB: http://www.nlm.nih.gov/medlineplus/urinaryincontinence.html
urinary incontinence AE
CTCAE: E13042
HPO: HP_0000020
MP: MP_0003280
NCIt: C78497
SIDER: C0042024
clonus AE is a series of involuntary, rhythmic, muscular contractions and relaxations.
SJ, YH
WEB: http://en.wikipedia.org/wiki/Clonus
10009346
clonus AE causes large motions that are usually initiated by a reflex.
clonus AE
a skin discoloration AE which has an outcome of pallor, an unnatural paleness to the skin, generally attributable to anemia
10033546
pallor AE
HPO: HP_0008361
MP: MP_0003717
SIDER: C0030232
an hearing disorder AE that shows a persistent sensation of buzzing, ringing, clicking, or other noises in the ear
10043882
tinnitus AE
CTCAE: E10287
HPO: HP_0000360
MP: MP_0003741
NCIt: C50772
SIDER: C0040264
a digestive system AE which has an outcome of stomatitis, which is an inflammation of the mucous lining of the mouth
This is a type of inflammation.
WEB: http://medical-dictionary.thefreedictionary.com/stomatitis
10042128
stomatitis AE
HPO: HP_0010280
MP: MP_0003746
SIDER: C0038362
a digestive system AE which has an outcome of mouth mucosal ulceration, which is lesions through the mucous membrane of the mouth, usually associated with loss of tissue
According to the Vaccine Adverse Event Reporting System (VAERS), 'mouth ulceration' was mentioned in 246 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543).
mouth mucosal ulceration AE
MP: MP_0003747
a muscle adverse event AE that has an outcome of abnormal muscle tone, which is an anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation
YH
abnormal muscle tone AE
MP: MP_0004142
an abnormal muscle tone AE which has an outcome of hypertonia, which is increased muscle tension resulting in stiffness of the muscles in the resting state
YH
10020852
hypertonia AE
HPO: HP_0001276
MP: MP_0004143
SIDER: C0026826
an abnormal muscle tone AE which has an outcome of hypotonia, which is decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness
YH
10021118
hypotonia AE
HPO: HP_0009062
MP: MP_0004144
SIDER: C0026827
a muscle inflammation AE which has an outcome of myositis, which is an inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle
YH, MW
10028653
myositis AE
CTCAE:E12489
HPO: HP_0009071
MP: MP_0004510
NCIt:C27578
SIDER: C0027121
a muscle adverse event which has an outcome of muscle inflammation, which is a local accumulation of fluid, plasma proteins, and leukocytes in muscle
YH
muscle inflammation AE
MP: MP_0004511
a lymphocyte count abnormal AE that has an outcome of greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells
According to the Vaccine Adverse Event Reporting System (VAERS), 'lymphocytosis'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
EB
increased lymphocyte cell number AE
lymphocyte cell number increased AE
10025258
lymphocyte count increased AE
CTCAE: E12195
MP: MP_0005013
NCIt: C34791
an abnormal defecation AE that has an outcome of diarrhea, which is abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel
diarrhoea AE
WEB: http://medical-dictionary.thefreedictionary.com/diarrhea
10012735
diarrhea AE
MP: MP_0005036
a homeostasis AE which has an outcome of hypoxia, which is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases
YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/hypoxia
10021143
hypoxia AE
CTCAE:E13388
HPO: HP_0002795
MP: MP_0005039
NCIt:C3890
SIDER: C0242184
an infectious adverse event which has an outcome of the presence of various pathogenic organisms, or their toxins, in the blood or tissues that results in the infections in blood stream.
According to the Vaccine Adverse Event Reporting System (VAERS), 'sepsis' was mentioned in 416 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543).
SS
10040047
sepsis AE
CTCAE: E11560
HPO: HP_0002718
MP: MP_0005044
NCIt: C3364
SIDER: C0243026
a urinary system AE that results in the presence of blood in the urine
YH, SJ, MW
UMLS CUI: C0018965 (hematuria AND haematuria); UMLS CUI: C0947999 (blood urine presence)
blood urine
blood urine presence
haematuria AE
WEB: http://kidney.niddk.nih.gov/kudiseases/pubs/hematuria/
10018867
10018870
10019450
Hematuria AE can be caused by menstruation, vigorous exercise, sexual activity, viral illness, trauma, or infection, such as a urinary tract infection (UTI), along with more serious disorders such as cancer, disease, and clotting.
hematuria AE
CTCAE: E13000
MP: MP_0005161
NCIt: C3090
a homeostasis AE which has an outcome of abnormal enzyme level, which is an altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances
abnormal enzyme level AE
MP: MP_0005319
an arrhythmia AE that has an outcome of fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
YH, JX
heart rate decreased AE
10019301
decreased heart rate AE
MP: MP_0005333
an adverse event that has an outcome of urinary system AE is a functional anomaly of any of the organs involved in the production or excretion of urine
YH
urinary system AE
MP: MP_0005502
an abnormal body temperature AE which has an outcome of decreased body temperature, which is less than the level of heat natural to a living being
YH, SJ
decreased body temperature AE
10021113
Hypothermia AE is a medical emergency that occurs when your body loses heat faster than it can produce heat, causing a dangerously low body temperature.
hypothermia AE
CTCAE: E11122
MP: MP_0005534
NCIt: C78351
a homeostasis AE whic has an outcome of abnomal body temperature, which is a deviation in the level of heat natural to a living being
abnormal body temperature AE
MP: MP_0005535
a peripheral neuropathy AE which has an outcome of neuritis, the local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord
10029240
neuritis AE
MP: MP_0006082
diplopia AE
10013036
an abnormal vision AE which has an outcome of double vision, which is two images perceived when only a single object is present
double vision AE
MP: MP_0006150
an anemia AE which has an outcome of hypochromic anemia, which is a hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs
hypochromic anemia AE
MP: MP_0008387
an adverse event that is indicated by an abnormal result of an investigation that uses some laboratory equipment, device, or medical technology.
This term is used to replace 'lab test abnormal AE'. The reason for this is that some test, like X-ray test, is not considered by many physicians as a lab test. Therefore, we have used this new term to cover a broader scope. All terms asserted under this term represent the investigation results without defined conclusion of disease.
EB, SS, YH
laboratory test abnormal
10061253
investigation result abnormal AE
a movement disorder AE that has an outcome of nervous
According to the Vaccine Adverse Event Reporting System (VAERS), 'nervousness' is an adverse event that was mentioned in 583 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543).
increased, skittish, behavior induced by stimulation such as handling, touching or noise
nervous AE
MP: MP_0008912
a hemorrhage AE that has an outcome of ecchymosis
10014080
an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis
ecchymosis AE
HPO: HP_0000978
MP: MP_0009276
SIDER: C0013491
serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death.
YH, MC
serious adverse event
severe adverse event
WEB: http://en.wikipedia.org/wiki/Serious_adverse_event
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA
serious adverse event
a serious adverse event that has an outcome of death.
YH
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
10011906
10011914
death AE
CTCAE: E11080
HPO: HP_0001645
NCIt: C28554
SIDER: C1306577
a serious AE that is suspected to put the patient at substantial risk of dying at the time of the adverse event, or that the use or continued use of the device or other medical product might have resulted in the death of the patient.
DJ, SS, YH, JX
apparent life threatening event AE
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
10065044
life-threating AE
a serious adverse event that leads to hospitalization. Such an adverse event resulted in an admission to the hospital or prolongation of hospitalization.
YH, JX
adverse event leading to hospitalization
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
hospitalization AE
a serious adverse event that leads to disability or permanent damage. Such an adverse event results in a substantial disruption of a person's ability to conduct normal life functions, i.e., the adverse event resulted in a significant, persistent or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities and/or quality of life.
YH, JX
adverse event leading to disability
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
disability or permanent damage AE
a serious adverse event that resulted in congenital anomaly and bith defect, leading to suspicions that an exposure to a medical product prior to conception or during pregnancy resulted in an adverse outcome in the child.
YH, JX
adverse event leading to congenital anomaly
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
WEB: http://www.thefreedictionary.com/birth+defect
10010356
congenital anomaly or birth defect AE
a serious adverse event which is an adverse event that requires intervention to prevent permanent impairment or damage leads to suspicions that the use of a medical product may result in a condition which requires a medical or surgical intervention to preclude permanent impairment or damage to a patient.
YH, JX
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
adverse event that requires intervention to prevent permanent impairment or damage
an adverse event that is considered not serious.
YH, MC
WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA
non-serious adverse event
low-grade fever AE is a fever adverse event with a temperature between 100° F and 102.2° F (37.8° C and 39° C).
YH
WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521
The low-grade level of fever is beneficial. With most microbes/"bugs" that a child will be exposed to, this fever will assist the body in repelling the invader.
low-grade fever AE
moderate-grade fever AE is a fever adverse event with a temperature typically between 102.2° F and 104.5° F (39° C and 40° C).
YH
WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521
This moderate-grade fever temperature is still considered beneficial. If a child's body has reached this temperature, it's what's needed to kill whatever bacteria or virus their body is attempting to fight.
moderate-grade fever AE
high-grade fever AE is a fever adverse event with a fever temperature greater than 104.5° F (40° C).
YH
WEB: http://www.toyourhealth.com/mpacms/tyh/article.php?id=1521
This fever may cause the child some discomfort and result in crankiness. Generally indicative of a bacterial infection, this fever means that the body is fighting something more serious than the common cold.
high-grade fever AE
hyperpyrexia AE is a fever adverse event that has an outcome of an excessive and unusual elevation of set body temperature greater than or equal to 41 °C. It is an extremely high fever. Such a high temperature is considered a medical emergency as it may indicate a serious underlying condition such as sepsis.
YH
extreme pyrexia AE
Axelrod YK1, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin. 2008 May;26(2):585-603, xi. doi: 10.1016/j.ncl.2008.02.005. PMID: 18514828.
WEB: http://en.wikipedia.org/wiki/Hyperpyrexia
10020741
hyperpyrexia AE
HPO: HP_0001945
SIDER: C0392676
a pain AE that has an outcome of musculoskeletal pain
SS, YH
WEB: http://www.webmd.com/pain-management/guide/musculoskeletal-pain
10028391
Musculoskeletal pain is pain that affects the muscles, ligaments and tendons, along with the bones.
musculoskeletal pain AE
HPO: HP_0003326
SIDER: C0026858
injection-site erythema AE is an erythema AE that results in redness of skin, caused by hyperermia of the capillaries in the lower layers of the skin at the physical area of injection
SS, YH
WEB: http://en.wikipedia.org/wiki/Erythema
WEB: http://medical-dictionary.thefreedictionary.com/erythema
10022061
injection-site erythema AE
Erythema AE is a skin adverse event that showns redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin.
SS, YH
reddish skin
WEB: http://en.wikipedia.org/wiki/Erythema
10015150
erythema AE
HPO: HP_0010783
MP:0001190
SIDER: C0041834
a headache AE that has an outcome of sinus headache
YH, SS
WEB: http://american-rhinologic.org/patientinfo.headache.phtml
sinus headache is a headache located over the sinuses, (forehead, corners of the eye, and cheek areas). On occasion, the pain will be felt behind the eyes, in the back of the neck, or may extend into the upper teeth.
sinus headache AE
HPO: HP_0002315
SIDER: C0037195
an inflammation AE that occurs in the lung. It is often characterized as including inflammation of the parenchyma of the lung (that is, the alveoli) and abnormal alveolar filling with fluid (consolidation and exudation).
SS, YH
WEB: http://en.wikipedia.org/wiki/Pneumonia
10035664
pneumonia AE
HPO: HP_0002090
SIDER: C0032285
lobar pneumonia is pneumonia AE that affects a large and continuous area of the lobe of a lung
SS, YH
WEB: http://en.wikipedia.org/wiki/Lobar_pneumonia
10024738
lobar pneumonia AE
HPO: HP_0002090
SIDER: C0032300
axillary pain AE is a pain AE that occurs in the underarm (the area on the human body directly under the join where the arm connects to the shoulder)
SS, YH
axillary pain AE
an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise.
YH: MedDRA ID: 10018852 is for "haematoma"; MedDRA ID: 10019428 is for "hematoma".
SS, YH
bruise AE
bruising AE
ecchymoses AE
haematoma AE
WEB: http://en.wikipedia.org/wiki/Hematoma
10006504
10018852
10019428
hematoma AE
CTCAE: E13775 (hematoma); CTCAE: E11666 (brruising)
HPO: HP_0001892
NCIt: C37921 (Bruising); NCIt: C50579 (Hematoma)
SIDER: C0018944
reproductive system AE is an AE that occurs in the reproductive system.
YH, SS
reproductive system AE
an immune system disorder AE which has an outcome of antinuclear antibody negative
SS, YH
antinuclear antibody negative AE
a CSF test result abnormal AE that has an outcome of CSF white blood cell count negative
SS, YH, EB
10061099
CSF white blood cell count negative AE
a microbiology and serology investigation result abnormal AE that has an outcome of positive influenza serology test result
SS, YH, EB
10060078
influenza serology positive AE
YH
a paralysis AE that has an outcome of VIIth nerve paralysis
10050040
VIIth nerve paralysis AE
HPO: HP_0006824
SIDER: C0919980
an aspartate aminotransferase level abnormal AE that has an outcome of an increased amount of AST, an enzyme normally present in body tissues especially of the heart and liver
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/aspartate+aminotransferase
10003481
aspartate aminotransferase level increased AE
CTCAE: E12087
NCIt: C26947
an incorrect dose administration that accidentally uses overdose
SS, YH
10000381
accidental overdose in medical intervention
an immune system disorder AE which has an outcome of acute disseminated encephalomyelitis
SS, YH
WEB: http://en.wikipedia.org/wiki/Acute_disseminated_encephalomyelitis
10000709
Acute disseminated encephalomyelitis (ADEM) is an immune mediated disease of the brain. It usually occurs following a viral infection but may appear following vaccination, bacterial or parasitic infection, or even appear spontaneously. As it involves autoimmune demyelination, it is similar to multiple sclerosis, and is considered part of the Multiple sclerosis borderline diseases.
acute disseminated encephalomyelitis AE
an arrhythmia AE that involves the two upper chambers (atria) of the heart
SS, YH
AF
WEB: http://en.wikipedia.org/wiki/Atrial_fibrillation
WEB: http://medical-dictionary.thefreedictionary.com/atrial+fibrillation
10003658
Atrial fibrillation (AF or A-fib) is the most common cardiac arrhythmia (abnormal heart rhythm), and involves the two upper chambers (atria) of the heart. Its name comes from the fibrillating (i.e., quivering) of the heart muscles of the atria, instead of a coordinated contraction.
atrial fibrillation AE
CTCAE: E10081
HPO: HP_0005110
NCIt: C50466
SIDER: C0004238
a cardiac disorder AE which has an outcome of abnormal heart rhythm
SS, YH
abnormal heartbeat AE
cardiac arrhythmia AE
WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/arr/
10003119
arrhythmia AE
HPO: HP_0011675
MP: MP_0004085
SIDER: C0003811
a cardiac valve disease AE that is characterized by a condition of the heart in which one of the valve openings has become narrow and restricts the flow of blood from the upper left chamber (left atrium) to the lower left chamber (left ventricle).
SS
WEB: http://medical-dictionary.thefreedictionary.com/mitral+valve+stenosis
10027733
mitral valve stenosis AE
a blood creatinine level abnormal AE that has an outcome of decreased blood creatine
SS, YH, EB
10005482
blood creatinine level decreased AE
SS, YH, EB
10007223
carbon dioxide decreased AE
a carbon dioxide abnormal AE that has an outcome of a decreased level of carbon dioxide in the blood
A contraindication that is specifically for vaccination.
SS, YH
contraindication to vaccination
an infection adverse event that has an outcome of croup infection
SS, YH
WEB: http://www.medicinenet.com/croup/article.htm
Croup is an infectious illness of the respiratory system involving the vocal cords (larynx), the windpipe (trachea), and the upper airways of the lungs (bronchial tubes). The majority of a child's symptoms reflect involvement of the larynx. Croup is usually a viral infection and maybe caused by many different viruses, including those responsible for the common cold and influenza. Rarely, croup is caused by a bacterial infection.
croup infection AE
a respiratory system AE that has an outcome of the drawing of a foreign substance into the respiratory tract during inhalation
DJ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/aspiration
10003504
aspiration AE
CTCAE:E13310
HPO: HP_0002835
NCIt:C15631
SIDER: C0700198
a respiratory system AE that has an outcome of the removal of gas or fluid from the pleural cavity of the lungs
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/aspiration
10003522
aspiration pleural cavity AE
a skin adverse event which has an outcome of excoriation AE is an injury to a surface of the body caused by trauma, such as scratching, abrasion, or a chemical or thermal burn.
SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/excoriation
10049796
excoriation AE
a pain AE that has an outcome of facial pain
SS, YH
WEB: http://www.bettermedicine.com/article/facial-pain
10016059
facial pain is a pain in facial area (eyes, eyebrows, forehead, nose, cheeks, mouth, teeth and chin). Facial pain may include injuries to the nerves or bones that coordinate many of your face’s actions.
facial pain AE
CTCAE: E11094
HPO: HP_0100661
NCIt: C79594
SIDER: C0015468
a hematology investigation result abnormal AE that has an outcome of abnormal full blood count
SS, YH, EB
10017412
10064198
full blood count abnormal AE
a reflexes decreased AE that has an outcome of hyporeflexia
SS, YH
WEB: http://en.wikipedia.org/wiki/Hyporeflexia
10021089
hyporeflexia is the condition of below normal or absent reflexes. Hyporeflexia is generally associated with a lower motor neuron deficit (at the alpha motor neurons from the spinal cord to muscle).
hyporeflexia AE
HPO: HP_0009072
SIDER: C0151888
a tumor AE that is characterized by cancer in the brain
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/astrocytoma
10003571
astrocytoma AE
HPO: HP_0009592
SIDER: C0004114
a medical intervention that uses incorrect dose
SS, YH
10064355
incorrect dose administration
a lung disorder AE that has an outcome of collapse in part of or all of a lung
DJ, SS, YH, MW
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001130/
10003598
atelectasis AE
CTCAE:E13316
HPO: HP_0001642
NCIt:C2888
SIDER: C0004144
an influenza serology positive AE that has an outcome of positive result in an influenza virus test
SS, YH, EB
10070717
influenza virus test positive AE
joint range of motion decreased AE is a mobility decreased AE that results in limited or decreased range of joint motion
SS, YH, MW
10048706
joint range of motion decreased AE
CTCAE: E12435
NCIt: C78403
a muscle spasm AE which has an outcome of laryngospasm, which is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. The condition typically lasts less than 60 seconds, and causes a partial blocking of breathing in, while breathing out remains easier. It may be triggered when the vocal cords or the area of the trachea below the cords detects the entry of water, mucus, blood, or other substance. It is characterized by stridor and or retractions.
SS, YH, MW
WEB: http://en.wikipedia.org/wiki/Laryngospasm
10023891
laryngospasm AE
CTCAE:E13439
HPO: HP_0006511
NCIt:C79609
SIDER: C0023066
a lymphocyte percentage abnormal AE that has an outcome of decreased lymphocyte percentage
SS, YH, EB
10052231
lymphocyte percentage decreased AE
a monocyte percentage abnormal AE that has an outcome of increased monocyte percentage
SS, YH, EB
10052230
monocyte percentage increased AE
a nuclear magnetic resonance imaging result abnormal AE that has an outcome of abnormal nuclear magnetic resonance imaging test of the brain
SS, YH
10029818
nuclear magnetic resonance imaging brain abnormal AE
periorbial edema AE is an edema AE that has an outcome of swelling around the eye.
MedDRA: 10034545 is for "periorbital edema"; MedDRA: 10054541 is for "periorbital oedema"
SS, YH
periorbital oedema AE
periorbital puffiness
WEB: http://en.wikipedia.org/wiki/Periorbital_puffiness
Periorbital puffiness, also known as "puffy eyes" or swelling around the eyes, refers to the appearance of swelling in the tissues around the eyes, called the orbits.
periorbital edema AE
CTCAE: E13676
NCIt: C78530
UMLS CUI: C0151205
a physical quality of a process that shows a positive result of a pregnancy test.
SS, YH
10036556
10036575
pregnancy test positive
a blood magnesium abnormal AE that has an outcome of an abnormally high concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors.
YH, MW
WEB: http://emedicine.medscape.com/article/246489-overview
10020670
hypermagnesemia AE
CTCAE: E12288
NCIt: C37969
UMLS CUI: C0151714
a sensory capability AE that has an outcome of a sensation feeling of foreign body
SS, YH
10061549
sensation of foreign body AE
a sensory capability AE that has an outcome of a sensation feeling of heaviness
SS, YH
feeling heavy AE
sensation of heaviness AE
a sensory capability AE that has an outcome of a loss of sensation
SS, YH
10040030
sensory loss AE
HPO: HP_0003474
SIDER: C0278134
a skin adverse event that has an outcome of skin exfoliation
SS, YH
10040844
skin exfoliation AE
HPO: HP_0007549
SIDER: C0237849
a digestive system AE which has an outcome of stomach discomfort
SS, YH
stomach upset AE
胃部不适
10042124
stomach discomfort AE
an immunology and allergy investigation result abnormal AE that has an outcome of autoantibodies present
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/autoantibody
10060973
autoantibody positive AE
a wheezing AE which has an outcome of stridor, a high pitched wheezing sound resulting from turbulent air flow in the upper airway. It is primarily inspiratory. It can be indicative of serious airway obstruction from severe conditions such as epiglottitis, a foreign body lodged in the airway, or a laryngeal tumor.
SS, YH, MW
WEB: http://en.wikipedia.org/wiki/Stridor
10042241
stridor AE
CTCAE:E13579
HPO: HP_0010307
NCIt:C78632
SIDER: C0038450
a skin AE that shows a result of skin ulcer, i.e., a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat.
SS, YH, MW
skin ulcer AE
WEB: http://en.wikipedia.org/wiki/Ulcer_%28dermatology%29
10040943
10040947
skin ulceration AE
CTCAE: E13730
HPO: HP_0200042
NCIt: C54247
SIDER: C0037299
an incorrect dose administration that uses underdose
SS, YH
underdose adminstration in medical intervention
a respiratory tract congestion AE which has an outcome of upper respiratory tract congestion
SS, YH
upper respiratory tract congestion AE
a urinary system investigation result abnormal AE that has an outcome of a urine analysis abnormality
SS, YH, EB
10062226
urine analysis result abnormal AE
a urine analysis result abnomal AE that shows ketone body present in urine
SS, YH, EB, QL
10057597
urine ketone body present AE
a liver/biliary system AE that has an outcome of inflammation of the liver that occurs when immune cells mistake the liver's normal cells for harmful invaders and attack them
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001291/
10003827
autoimmune hepatitis AE
HPO: HP_0004787
SIDER: C0241910
a hemorrhage AE that has an outcome of vaginal hemorrhage
MedDRA: 10046910 is for "vaginal haemorrhage"; MedDRA: 10046912 is for "vaginal hemorrhage"
SS, YH, MW
vaginal haemorrhage AE
WEB: http://www.brooksidepress.org/Products/Military_OBGYN/Textbook/AbnormalBleeding/Bleeding.htm
vaginal hemorrhage is irregular/heavy bleeding from the vagina. Vaginal hemorrhage is more often associated with pregnancy complications such as miscarriage or placental abruption, but certainly can occur in the absence of pregnancy.
vaginal hemorrhage AE
CTCAE: E13264
NCIt: C26945
SS, YH
WEB: http://en.wikipedia.org/wiki/Vasodilation
a cardiovascular disorder AE which has an outcome of vasodilatation, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins.
vasodilatation AE
HPO: HP_0004927
SIDER: C0595862
a bacterial infection AE that has an outcome of bacteria in the blood
DJ, SS, YH
bacteraemia AE
WEB: http://medical-dictionary.thefreedictionary.com/bacteremia
10003997
bacteremia AE
a sepsis AE caused by bacterial infection in the bloodstream or body tissues
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/sepsis
10053840
bacterial sepsis AE
a skin AE that has an outcome of a slow-growing nonmelanoma skin cancer
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001827/
10004146
basal cell carcinoma AE
HPO: HP_0002671
SIDER: C0007117
a basophil count abnormal AE that is characterized by increase in the number of basophils in the body
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/basophil+granulocyte
10004169
basophil count increased AE
an ulcer AE that is characterized by ulcers in the mouth that may decrease ocular functionality
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/behcet's+disease
10004213
behcet's syndrome AE
a musculoskeletal system AE that has an outcome of low muscle tone
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/hypotonia
10051900
benign congenital hypotonia AE
a female reproductive system AE that has an outcome of a non-fertilized egg that implants itself in the uterus and turns a normal pregnancy into an abnormal one
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/hydatidiform+mole
10004272
benign hydatidiform mole AE
a benign tumor AE that has an outcome of a benign tumor in their ovaries
DJ, SS, YH
benign ovarian tumour AE
10004433
benign ovarian tumor AE
a digestive system AE that has an outcome of a blockage in the tubes that carry bile from the liber to the gallbladder and small intestine
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000263.htm
10056375
bile duct obstruction AE
a liver/biliary system AE that has an outcome of dilating or stretching of the bile duct
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21843715
10057202
biliary dilatation AE
an eating disorder that is characterized by episodes of uncontrollable eating.
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/binge+eating
10004716
binge eating AE
an eye disorder AE that has an outcome of binocular eye movement disorder where control and alignment of eyes are compromised
DJ, SS, YH
WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/23201436 Secondary Source: http://brain.oxfordjournals.org/content/119/6/1933.full.pdf
10061010
binocular eye movement disorder AE
a digestive system AE that has an outcome of cancer that starts in the bladder, the body part that holds and releases urine in the center of the lower belly area
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001517/
10005003
bladder cancer AE
HPO: HP_0009725
SIDER: C0005684
a blast cell count abnormal AE that has an outcome of an increased amount of immature precursors of either lymphocytes or granulocytes that do not normally appear in peripheral blood. May indicate acute leukemia
DJ, SS, YH
WEB: http://meds.queensu.ca/medicine/deptmed/hemonc/anemia/blast.htm
10062274
blast cell count increased AE
a hematopoietic system AE that has an outcome of a sudden, severe change in the course of chronic granulocytic leukemia with an increase in the proportion of myeloblasts
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/blast+crisis
10053747
blast cell crisis AE
a hematopoietic system AE that has an outcome of myeloblasts or myeloid blasts. Presence of these abnormal blasts prevent production of adequate platelets, red blood cells and white blood cells, can be associated with leukemia
DJ, SS, YH
WEB: http://lymphoma.about.com/od/glossary/ss/Blast-Cells.htm
10057107
blast cells present AE
a hematopoietic system AE that has an outcome of the last stage of chronic myelogenous leukemia characterized by rapid progression and short survival with an increase of myeloblasts or lymphoblasts in the blood or bone marrow
DJ, SS, YH
blast crisis in myelogenous leukaemia AE
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/blast+crisis , Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23171293
10050282
blast crisis in myelogenous leukemia AE
an eye inflammation AE that has an outcome of swelling in the eyelids, usually where eyelash follicles are located
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002586/
10005148
blepharitis AE
HPO: HP_0000498
SIDER: C0005741
a blood albumin level abnormal AE with an outcome of a decrease in the amount of albumin, a protein made by the liver
DJ, SS, YH, EB
hypoalbuminemia AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003480.htm
10005287
blood albumin level decreased AE
a liver related investigation result abnormal AE that has an outcome of an abnormal level of alkaline phosphatase in the blood
DJ, SS, YH, EB
10059571
blood alkaline phosphatase level abnormal AE
a blood alkaline phosphatase abnormal AE that has an outcome of a decreased level of alkaline phosphatase in the blood
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase
10059569
blood alkaline phosphatase decreased AE
a blood alkaline phosphatase abnormal AE that has an outcome of elevated levels of alkaline phosphatase, an enzyme responsible for removing phosphate groups. a liver/biliary system AE that has an outcome of an increased amount of ALP, an isoenzyme that removes phosphate groups commonly found in the bile ducts but also found in the bone
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/alkaline+phosphatase
10001675
10059570
blood alkaline phosphatase increased AE
CTCAE: E12082
HPO: HP_0003155
NCIt: C35607
SIDER: C0852911
a distal neuropathy AE which shows a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. It is caused by the loss of myelin sheath of the peripheral nerves.
AG, YH
CIDP
Chronic Inflammatory Demyelinating Polyneuropathy
WEB: http://www.ninds.nih.gov/disorders/cidp/cidp.htm
chronic inflammatory demyelinating neuropathy AE
a blood amylase level abnormal AE that has an outcome of an increased amount of amylase, an enzyme that helps digest carbohydrates; may indicate disease or inflammation of the pancreas
DJ, SS, YH, EB
serum amylase increased AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003464.htm
10005328
10040139
blood amylase level increased AE
CTCAE: E12212
NCIt: C78608
a liver related investigation result abnormal AE that has an outcome of an abnormal amount of bilirubin in the blood
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/bilirubin
10058477
blood bilirubin level abnormal AE
a blood bilirubin level abnormal AE with an outcome of a increased amount of bilirubin, or a yellow breakdown product (broken down hemoglobin) of normal heme catabolism, in the blood
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/bilirubin
10005364
blood bilirubin level increased AE
CTCAE: E12096
NCIt: C27088
a physical quality that has a decreased amount of calcium in the bloodstream
DJ, SS, YH
10005395
blood calcium decreased
A physical quality that has an decreased level of chloride ion in the blood, excessive loss may be due to sweating, vomiting and adrenal gland/kidney disease
DJ, SS, YH
WEB: http://www.medterms.com/script/main/art.asp?articlekey=9940
10005419
blood chloride decreased
HPO: HP_0003113
SIDER: C0595902
a blood cholesterol abnormal AE with the result of an increase in cholesterol level in the blood
DJ, SS, YH, EB
10005425
blood cholesterol increased AE
CTCAE: E12127
HPO: HP_0003124
NCIt: C37967
SIDER: C0595930
an enzyme investigation result abnormal AE that has an outcome of abnormal levels of creatine phosphokinase in the blood
DJ, SS, YH, EB
10005468
blood creatine phosphokinase level abnormal AE
a blood creatinine level abnormal AE that has an outcome of an increased level of creatinine in the blood (due to lack of kidney activity)
DJ, SS, YH, EB
creatinine increased AE
serum creatinine increased
WEB: http://medical-dictionary.thefreedictionary.com/creatinine
10005483
10011368
blood creatinine level increased AE
CTCAE: E12137
NCIt: C78249
an infection adverse event that has an outcome of bacteria or yeasts in the blood
DJ, SS, YH
WEB: http://labtestsonline.org/understanding/analytes/blood-culture/tab/test
10005488
blood culture positive AE
a hematopoietic system AE that has an outcome of disease in the blood, a living tissue made up of plasma and red blood cells, white blood cells and platelets. Blood disorders affect one or more parts of the blood and prevent the blood from doing this job.
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/blooddisorders.html
10061590
blood disorder AE
a blood folate abnormal AE that has an outcome of a decreased level of folate in the blood
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/folate
10005527
blood folate level decreased AE
a blood glucose level abnormal AE that has an outcome of a decrease of glucose levels in blood
DJ, SS, YH, EB
10005555
blood glucose level decreased AE
a blood glucose level abnormal AE that has an outcome of an increased glucose level in blood
DJ, SS, YH, EB
10005557
blood glucose level increased AE
a blood homocysteine level abnormal AE that has an outcome of an increased levels of homocysteine in the blood
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/homocysteine
10049733
blood homocysteine level increased AE
an immunology and allergy investigation result abnormal AE that results in an increased immunoglobulin a level in the blood
DJ, SS, YH, EB
IgA level increased
WEB: http://medical-dictionary.thefreedictionary.com/immunoglobulin+A
10005586
blood immunoglobulin A level increased AE
a blood lactate dehydrogenase level abnormal AE that has an outcome of an increased amount of LDH, an enzyme that could indicate tissue damage
DJ, SS, YH, EB
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003471.htm
10005630
blood lactate dehydrogenase level increased AE
A physical quality that has an decreased level of magnesium, a mineral involved in nerve signaling and bone health. Deficiency can cause spasms, and muscular cramps.
DJ, SS, YH
WEB: http://www.medterms.com/script/main/art.asp?articlekey=4243
10005654
blood magnesium decreased
HPO: HP_0002917
SIDER: C0853750
a blood parathyroid hormone level abnormal AE that has an outcome of a decrease in the level of parathyroid hormone in the blood
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/parathyroid+hormone
10005702
blood parathyroid hormone decreased AE
A physical quality that has an decreased level of decreased phosphorus in the blood
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003478.htm
10049471
blood phosphorus decreased
HPO: HP_0002148
SIDER: C0877517
a physical quality where the blood potassium level is decreased.
DJ, SS, YH, LW, MW
血钾下降
10005724
blood potassium decreased
HPO: HP_0002900
a hypotension AE that has an outcome of a decrease in the amount of pressure in the arteries when the heart is at rest between beats
DJ, SS, YH
WEB: http://www.mayoclinic.com/health/low-blood-pressure/DS00590/DSECTION=causes
10005737
blood pressure diastolic decreased AE
a hypotension AE that has an outcome of immeasurable blood pressure
DJ, SS, YH
10005748
blood pressure immeasurable AE
A physical quality that has an decreased level of sodium concentration in the blood
DJ, SS, YH, MW
10005802
blood sodium decreased
a blood thromboplastin level abnormal AE that has an outcome of an increase in the level of thromboplastin in the blood
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/thromboplastin
10005827
blood thromboplastin level increased AE
a blood urea level abnormal AE with an outcome of a decreased amount of urea nitrogen in the blood, below 7 to 21 mg of urea per 100 ml
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/blood+urea+nitrogen
10005850
blood urea level decreased AE
a blood urea level abnormal AE that results in an increase in amount of urea in blood
DJ, SS, YH, EB
10005851
blood urea level increased AE
a blood uric acid level abnormal AE that has an outcome of an increase in uric acid in the blood; excess purines may accumulate in tissues and form crystals
DJ, SS, YH, EB
WEB: http://chemocare.com/chemotherapy/side-effects/hyperuricemia-high-uric-acid.aspx
10005861
blood uric acid level increased AE
a bone disorder AE that has an outcome of a cyst that forms on the bone
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/bone+cyst
10005952
bone cyst AE
a bone disorder AE that has an outcome of surgery to clean and flush out the infected bone
DJ, SS, YH
WEB: http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Osteomyelitis
10057612
bone debridement AE
a bone disorder AE that has an outcome of an anomlay in the growth or structure of a bone
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/20972590
10061728
bone lesion AE
a bone marrow disorder AE that has an outcome of an abnormal condition in which the bone marrow is unable to produce normal amounts of red blood cells, white blood cells and platelets
DJ, SS, YH, MW
bone marrrow hypocellular
hypocellular bone marrow
WEB: http://en.diagnosispro.com/differential_diagnosis-for/bx-bone-marrow-biopsy-hypocellular/29777-154.html
WEB: http://www.drugs.com/condition/bone-marrow-depression-low-blood-counts.html
10005986
10048580
Bone marrow produces three types of blood cells; red blood cells, white blood cells and platelets. Bone marrow depression is characterized by an inability or reduced ability of the bone marrow to produce these cells. A low blood count can involve just one or all three types of blood cells.
bone marrow depression AE
CTCAE: E10022
HPO: HP_0012145
NCIt: C35167
SIDER: C0151773
UMLS: C0151773
a hematopoietic system AE that has an outcome of disease in the bone marrow, the spongy tissue inside of some bones that contain stem cells that can develop into red blood cells, white blood cells or platelets
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/bonemarrowdiseases.html
10061729
bone marrow disorder AE
a bone marrow disorder AE that has an outcome of an insufficient amount of red blood cells, white blood cells or platelets, associated with fanconii anemia, dyskeratosis congenita, and aplastic anemia
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23271412
10065553
bone marrow failure AE
a bone marrow disorder AE that has an outcome of an excess formation of connective tissue in the bone marrow
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22246040
10069678
bone marrow reticulin fibrosis AE
a bone marrow disorder AE that has an outcome of the decrease in cells responsible for providing immunity, carrying oxygen and blood clotting
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/12806941
10051779
bone marrow toxicity AE
HPO: HP_0005561
SIDER: C0948168
a bone marrow disorder AE that has an outcome of the replacement of damaged bone marrow with healthy bone marrow stem cells
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003009.htm
10061730
bone marrow transplant AE
a swelling AE that results in swelling around a bone
DJ, SS, YH
10053631
bone swelling AE
a skin adverse event that has an outcome of an early stage of squamous cell carcinoma
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/bowen's+disease
10006059
bowen's disease AE
a bradycardia AE that results in a decreased heart rate in a neonate
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/10822186
10056471
bradycardia neonatal AE
HPO: HP_0001662
SIDER: C1112488
an edema AE that has an outcome of edema or swelling of the extravascular compartment from uptake of water in the gray and white matter
DJ, SS, YH
brain oedema AE
WEB: http://medical-dictionary.thefreedictionary.com/cerebral+edema
10048962
brain edema AE
HPO: HP_0002181
SIDER: C1527311
a tumor AE that has an outcome of cancer in the breast
DJ, SS, YH
10006187
breast cancer AE
HPO: HP_0003002
SIDER: C0006142
a breast cancer AE that has an outcome of cancerous cells spreading to the breast
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001911/
10055113
breast cancer metastatic AE
a breast cancer AE that has an outcome of breast cancer at the stage III level
DJ, SS, YH
10006201
breast cancer stage iii AE
an infection AE that results in the breast becoming infected
DJ, SS, YH
10006259
breast infection AE
CTCAE: E11318
HPO: HP_0002726
NCIt: C53662
SIDER: C0392317
a pain AE that results in pain in the breast
DJ, SS, YH, MW
10006298
breast pain AE
CTCAE:E13073
HPO: HP_0000769
NCIt:C78223
SIDER: C0024902
a reproductive system AE that has an outcome of pain or discomfort in the breast, may be caused by small benign tumors
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21979747
10006313
breast tenderness AE
HPO: HP_0100749
SIDER: C0262397
a pneumonia AE that has an outcome of acute inflammation of the walls of the smaller bronchial tubes, with irregular areas of consolidation due to spread of inflammation into peribronchiolar alveoli and the alveolar ducts of the lungs
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/bronchopneumonia
10006469
bronchopneumonia AE
HPO: HP_0006538
SIDER: C0006285
an immune system disorder AE that has an outcome of an exaggerated response of the immune system to the fungus Aspergillus
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/bronchopulmonary+aspergillosis
10006473
bronchopulmonary aspergillosis AE
HPO: HP_0002724
SIDER: C2350530
a lung disorder AE that has an outcome of a sudden constriction of the muscles in the walls of the bronchioles
DJ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/bronchospasm
10006482
bronchospasm AE
CTCAE:E13352
HPO: HP_0002099
NCIt:C34439
SIDER: C0006266
a sensory capability AE that results in a feeling of burning
DJ, SS, YH
10006784
burning sensation AE
a syndrom AE that has an outcome of a wasting syndrome characterized by weight loss, muscle atrophy, fatigue, and loss of appetite, often occurs with cancer.
DJ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Wasting+Syndrome Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23279159
10006895
cachexia AE
HPO: HP_0004326
SIDER: C0006625
a digestive system AE that has an outcome of inflammation of the caecum, part of the large intestine
DJ, SS, YH
caecitis AE
typhlitis AE
WEB: http://medical-dictionary.thefreedictionary.com/caecitis
10006919
cecitis AE
an endocrine system AE that has an outcome of deficiency of calcium in the body
DJ, SS, YH
10006956
calcium deficiency AE
a cardiovascular disorder AE that has an outcome of self-reversing episodes during which the endothelial cells which line the capillaries are thought to separate for a few days, allowing for a leakage of fluid from the circulatory system to the interstitial space, resulting in hypotension, hemoconcentration, and hypoalbuminemia
DJ, SS, YH, MW
Clarkson's Disease AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22873043
10007196
capillary leak syndrome AE
CTCAE:E13766
NCIt:C62578
a cytogenetic investigation result abnormal AE that has an outcome of an increase in a type of protein typically associated with tumors and the developing fetus
DJ, SS, YH, EB
WEB: http://www.medicinenet.com/carcinoembryonic_antigen/article.htm
10007266
carcinoembryonic antigen increased AE
a tumor AE that has an outcome of a carcinoid tumor that forms somewhere in the body
DJ, SS, YH
carcinoid tumour AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23307266
10007275
carcinoid tumor AE
HPO: HP_0006723
SIDER: C0007095
a blood chloride abnormal AE with an outcome of decrease in amount of chloride ion in the blood, excessive loss may be due to sweating, vomiting and adrenal gland/kidney disease
YH, MW
WEB: https://en.wikipedia.org/wiki/Hypochloremia
10020957
hypochloremia AE
HPO: HP_0003113
UMLS CUI: C0085680
a cardiovascular disorder AE that results in the inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body
DJ, SS, YH
heart failure
WEB: http://medical-dictionary.thefreedictionary.com/cardiac+failure
10007554
10019279
cardiac failure AE
CTCAE: E10124
HPO: HP_0001635
NCIt: C50577
SIDER: C0018801
a cardiovascular disorder AE that results in an inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body
DJ, SS, YH
congestive heart failure
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/congestive+heart+failure Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/21676684
10007559
cardiac failure congestive AE
HPO: HP_0001635
SIDER: C0018802
a surgery that implants a cardiac pacemaker, a device that supplies electrical impulses to the heart to maintain the heartbeat at a regular rate
DJ, SS, YH
WEB: http://www.mdguidelines.com/cardiac-pacemaker-insertion
10007598
cardiac pacemaker insertion
a cardiac disorder AE that has an outcome of disease involving one or more of the valves of the heart
DJ, SS, YH
valvular disease AE
WEB: http://medical-dictionary.thefreedictionary.com/valvular+heart+disease
10061406
cardiac valve disease AE
HPO: HP_0001654
SIDER: C0018824
a cardiac disorder AE that has an outcome of a disorder involving the ventricle(s) in the heart
DJ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/ventricular Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/15473469
10057455
cardiac ventricular disorder AE
a hypotension AE that has an outcome of the inability of the heart to supply enough blood to the organs of the body because of heart damage
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001237/
10007625
cardiogenic shock AE
a cardiovascular disorder AE that has an outcome of deterioration of the function of the myocardium, usually leads to heart failure
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy
WEB: https://en.wikipedia.org/wiki/Cardiomyopathy
10007636
cardiomyopathy AE
HPO: HP_0001638
SIDER: C0878544
a cardiovascular disorder AE that has an outcome of heart electrophysiology dysfunction and/or muscle damage. Is not efficient at pumping/circulating blood
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy
10048610
cardiotoxicity AE
a coronary artery disorder AE that results in lesion in carotid artery
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/8198401
10067116
carotid arteriosclerosis AE
a musculoskeletal system AE that has an outcome of loss of muscle tone due to emotional responses like laughing and crying
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/cataplexy
10007737
cataplexy AE
HPO: HP_0002524
SIDER: C0007384
a eye disorder AE that results in cloudiness that develops in the eye
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/cataract
10007739
cataract AE
CTCAE: E10350
HPO: HP_0000518
NCIt: C26713
SIDER: C0086543
a sugery AE that has an adverse outcome related to the use of catheter, a thin tube inserted in the body
DJ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/catheter Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23306712
10052253
catheter related complication AE
an infection AE that has an outcome of an infection (e.g., bacterial colonisation) at the catheter site
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/8825104
10007810
10056520
catheter related infection AE
CTCAE: E11328
HPO: HP_0002719
NCIt: C78232
SIDER: C0860239
a bacterial infection AE that is located at the catheter site
DJ, SS, YH
10056520
catheter site infection AE
a sugery AE that has an adverse outcome at the site where a catheter was used
DJ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/catheter Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23074085
10007811
catheter site related reaction AE
a cardiac disorder AE that has an outcome of a problem after inserting a catheter into the heart
DJ, SS, YH
catheterisation cardiac abnormal AE
WEB: http://medical-dictionary.thefreedictionary.com/cardiac+catheterization
10007816
catheterization cardiac abnormal AE
a behavior and neurological AE that has an outcome of an acute loss of function of the lumbar plexus
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23230403
10007821
cauda equina syndrome AE
a bacterial infection AE that is located at the central-line catheter site
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/7580945
10054192
central line infection AE
HPO: HP_0002719
SIDER: C1096243
an infection AE that is located in the central nervous system
DJ, SS, YH
10061036
central nervous system infection AE
HPO: HP_0005381
SIDER: C0007684
a tumor AE that has an outcome of lymphoma in the central nervous system
DJ, SS, YH
10007953
central nervous system lymphoma AE
an ataxia AE that is located in the cerebellum
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23283615
10008025
cerebellar ataxia AE
HPO: HP_0001251
SIDER: C0007758
a brain disorder AE that has an outcome of an inherited brain disorder that affects muscle coordination, may involve the tendency for limb movements to overshoot or undershoot a target, tremors and impaired rhythm
DJ, SS, YH
WEB: http://www.rightdiagnosis.com/medical/cerebellar_syndrome.htm
10008072
cerebellar syndrome AE
HPO: HP_0001317
SIDER: C0007760
a brain disorder AE with the outcome of hemorrhage or blood in the brain
DJ, SS, YH
cerebral haemorrhage AE
10008111
cerebral hemorrhage AE
HPO: HP_0001342
SIDER: C2937358
a brain disorder AE that results in the sudden death of brain cells in a localized area due to inadequate blood flow
DJ, SS, YH
cerebral ischaemia AE
ischemic stroke AE
WEB: http://medical-dictionary.thefreedictionary.com/Cerebral+ischaemia
10008120
cerebral ischemia AE
HPO: HP_0002637
SIDER: C0917798
a nervous system AE that has an outcome of pain or another sensation in the patient's neck and shoulder region
DJ, SS, YH
WEB: http://www.mdguidelines.com/cervicobrachial-syndrome/definition
10008334
cervicobrachial syndrome AE
a skin AE that has an outcome of dry lips caused by the evaporation of moisture.
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/9433089
10049047
chapped lips AE
an inflammation AE that occurs in the lip
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/cheilitis
10008417
cheilitis AE
CTCAE: E10517
HPO: HP_0100825
NCIt: C79545
SIDER: C0007971
a skin AE that has an outcome of a burn due to chemicals on the skin
DJ, SS, YH
10057941
chemical burn of skin AE
a discomfort AE that has an outcome of pain in the chest
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/chest+pain
10008469
chest discomfort AE
HPO: HP_0001681
SIDER: C0235710
alcohol cardiomyopathy AE
a progressive tumor AE that has an outcome of multiple, malignant, localized green masses of abnormal cells, usually myeloblasts, especially beneath the periosteum of the skull, spine and ribs
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/chloroma
10008583
chloroma AE
a digestive system AE that has an outcome of infection in the common bile duct, usually by bacterial infection
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001335/
10008604
cholangitis AE
HPO: HP_0011040
SIDER: NA
a liver/biliary system AE that has an outcome of a condition in which the flow of bile from the liver is slowed or blocked
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001263/
10008635
cholestasis AE
HPO: HP_0001396
SIDER: C0008370
an adverse event that has an outcome of calcium crystals of calcium pyrophosphate dihydrate accumulated in the connective tissues of the patient
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/chondrocalcinosis
10008690
chondrocalcinosis pyrophosphate AE
a cytogenetic investigation result abnormal AE that has an outcome of an abnormal chromosome pattern
DJ, SS, YH, EB
WEB: http://www.miscarriageclinic.co.uk/causes-and-treatments/chromosome-abnormality/
10008817
chromosome analysis abnormal AE
a peripheral neuropathy AE which has an outcome of a chemotherapy-induced neuropathy that affects nerves of the peripheral nervous system (PNS)
AG, YH
CIPN
WEB: http://www.cancer.org/treatment/treatmentsandsideeffects/physicalsideeffects/chemotherapyeffects/peripheralneuropathy/peripheral-neuropathy-caused-by-chemotherapy-what-is-cipn
chemotherapy-induced peripheral neuropathy AE
a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by increased and unregulated growth of myeloid cells in the bone marrow
DJ, SS, YH
chronic myeloid leukaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/chronic+myelogenous+leukemia
10009013
chronic myeloid leukemia AE
HPO: HP_0005506
SIDER: C0023473
a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. May transform from chronic myeloid leukaemia to acute myeloid leukaemia
DJ, SS, YH
chronic myeloid leukaemia transformation AE
WEB: http://www.jci.org/articles/view/41246
10068232
chronic myeloid leukemia transformation AE
a lung disorder AE that has an outcome of breathing difficulty with two main forms: chronic bronchitis and emphysema
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001153/
10009033
chronic obstructive pulmonary disease AE
HPO: HP_0006510
SIDER: C0024117
a respiratory system AE that results in inadequate gas exchange by the respiratory system
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/respiratory+failure
10009126
chronic respiratory failure AE
a respiratory system AE that has an outcome of inflammation in the cavities around the nasal passages
DJ, SS, YH
WEB: http://www.mayoclinic.com/health/chronic-sinusitis/DS00232
10009137
chronic sinusitis AE
a lung disorder AE that has an outcome of lymphatic fluid accumulating in the pleural cavity, the space between two pleura of the lungs
DJ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/chylothorax
10051228
chylothorax AE
CTCAE:E13358
NCIt:C79546
a cardiovascular disorder AE that has an outcome of insufficient circulation without congestive heart failure
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/circulatory+collapse
10009192
circulatory collapse AE
a bacterial infection AE that has an outcome of invasion by anaerobic bacteria of the genus Clostridium, can cause tetanus and botulism
DJ, SS, YH
WEB: http://www.medicinenet.com/clostridium_difficile_colitis/page2.htm
10061043
clostridial infection AE
HPO: HP_0004798
SIDER: C0009062
a digestive system AE that has an outcome of bacterial infection by clostridium difficile colitis, commonly results in diarrhea and colitis
DJ, SS, YH
10009657
clostridium difficile colitis AE
HPO: HP_0002583
SIDER: C0238106
a coagulation factor v level abnormal AE that has an outcome of a decreased level of the factor V protein in the coagulation system of the body
DJ, SS, YH, EB
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22781721
10009754
coagulation factor v level decreased AE
an inflammation AE that occurs at the large intestine
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002112/
10009887
colitis AE
CTCAE: E10521
HPO: HP_0002583
NCIt: C26723
SIDER: C0009319
a lung disorder AE that has an outcome of a collapsed lung, refering to the space between the wall of the chest cavity and the lung filling with air, causing all or a portion of the lung to collapse
DJ, SS, YH
Pneumothorax
10009913
collapse of lung AE
a tumor AE that has an outcome of cancer that starts in the large intestine or the rectum
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/
10009944
colon cancer AE
HPO: HP_0003003
SIDER: C0007102
a colon AE that has an outcome of cancerous cells spreading to the colon
DJ, SS, YH
WEB: http://www.cancer.gov/cancertopics/factsheet/Sites-Types/metastatic
10055114
colon cancer metastatic AE
a colon cancer AE that has an outcome of colon cancer at stage IV
DJ, SS, YH
10009956
colon cancer stage iv AE
a digestive system AE that has an outcome of cancer that starts in the large intestine or rectum.
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/
10061451
colorectal cancer AE
HPO: HP_0003003
SIDER: C1527249
a digestive system AE that has an outcome of cancer in the large intestine and the rectum. When metastatic, the cancer has already spead to distant sites and is considered stage IV.
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22642873
10052358
colorectal cancer metastatic AE
HPO: HP_0003003
SIDER: C0948380
an imaging investigation result abnormal AE that has an abnormal result of an imaging method in which a cross-sectional image of the structures in a body plane is reconstructed by a computer program from the x-ray absorption of beams projected through the body in the image plane
DJ, SS, YH, EB
computerised tomogram abnormal AE
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/computerized+tomography , Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23271098
WEB: http://medical-dictionary.thefreedictionary.com/computed+tomography
10010235
computerized tomography result abnormal AE
an adverse event that has an outcome of progression of underlying conditions that may affect drug distribution or metabolism
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Concomitant+disease
10048659
concomitant disease progression AE
an adverse event that has an outcome of condition that worsens
DJ, SS, YH
10010264
condition aggravated AE
a congenital abnormality AE that has an outcome of an abnormality in heart which is present at birth
DJ, SS, YH
WEB: http://www.thefreedictionary.com/congenital+heart+defect
10061054
congenital cardiovascular anomaly AE
HPO: HP_0001626
SIDER: C0243050
a cardiomyopathy AE that is characterized by the walls of the heart chambers stretching to hold a greater volume of blood than normal
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/congestive+cardiomyopathy
10056370
congestive cardiomyopathy AE
HPO: HP_0001635
SIDER: C0007193
an eye disorder AE that has an outcome of a problem involving the insides of the patient's eyelids
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/conjunctiva
10061446
conjunctival disorder AE
HPO: HP_0000502
SIDER: C0009759
a hemorrhage AE that has an outcome of a bright hemorrhagic patch on the bulbar conjunctiva caused by rupture and bleeding of a superficial small capillary due to increased pressure
DJ, SS, YH
conjunctival haemorrhage AE
10010719
conjunctival hemorrhage AE
HPO: HP_0007902
SIDER: C0009760
an adverse event that has an outcome of disease in the biological tissue that supports, binds together and protects organs
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/connective+tissue+disease
10061087
connective tissue disorder AE
HPO: HP_0003549
SIDER: C0009782
an eye disorder AE that has a result of the inability to use contact lenses
DJ, SS, YH
10010804
contact lens intolerance AE
a hematology investigation result abnormal AE that has an outcome of a positive coombs test, which is a blood test that identifies the causes of anemia
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/Coombs'+Tests
WEB: http://medical-dictionary.thefreedictionary.com/test
10061090
coombs' test positive AE
a behavior and neurological AE that results in a loss of coordination
DJ, SS, YH
10010947
coordination abnormal AE
HPO: HP_0011443
SIDER: C0520966
a cardiac disorder AE that has an outcome of treatment involving the stenotic coronary arteries in the heart
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/coronary+angioplasty
10050329
coronary angioplasty AE
a coronary artery disorder AE that has an outcome of an blockage in the coronary artery
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22953315
10011084
coronary artery embolism AE
a coronary artery disorder AE that has an outcome of an insufficient amount of blood circulates through the coronary arteries
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/coronary+insufficiency
10052895
coronary artery insufficiency AE
HPO: HP_0001677
SIDER: C0542052
a tumor AE that has an outcome of a brain tumor derived from the embryonic tissue of the pituitary gland
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/craniopharyngioma
10011318
craniopharyngioma AE
a c-reactive protein level abnormal AE that has an outcome of an increased amount of CRP, a protein that measure general levels of inflammation in the body
DJ, SS, YH, EB
WEB: http://www.webmd.com/a-to-z-guides/c-reactive-protein-crp
moved "c-reactive protein increased AE" from "cardiac AE" to "lab test abnormal AE" EB
10006825
c-reactive protein level increased AE
viral cardiomyopathy AE
a nervous system AE that has an outcome of increased pressure in the skull
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/intracranial+pressure
10011570
csf pressure increased AE
a urine analysis result abnormal AE that has an outcome of high bacterial colonization counts in the urine
DJ, SS, YH, EB
WEB: http://labtestsonline.org/understanding/analytes/urine-culture/tab/test
10011640
culture urine positive AE
an inflammation AE that has an outcome of inflamed blood vessels in the skin
DJ, SS, YH
WEB: http://dermnetnz.org/vascular/vasculitis.html
皮肤血管炎
10011686
cutaneous vasculitis AE
HPO: HP_0200029
SIDER: C0262988
a urinary system AE that has an outcome of cystitis with severe hemorrhage, a dose-limiting toxic condition with administration of ifosfamide and cyclophosphamide or a complication of bone marrow transplantation
DJ, SS, YH
cystitis haemorrhagic AE
WEB: http://medical-dictionary.thefreedictionary.com/hemorrhagic+cystitis
10011793
cystitis hemorrhagic AE
a genetic disorder AE that has an outcome of an atypical number of chromosomes or a structural abnormality in one or more chromosomes
DJ, SS, YH
10067477
cytogenetic abnormality AE
an inflammation AE that has an outcome of release of cytokines by T cells that causes inflammation
DJ, SS, YH
WEB: http://encyclopedia.thefreedictionary.com/cytokine+release+syndrome
10052015
cytokine release syndrome AE
CTCAE: E11264
NCIt: C78251
a liver/biliary system AE that has an outcome of liver cells carrying excess water, causing inflammation along with hepatitis
DJ, SS, YH
WEB: http://www.thirdage.com/hc/c/q/hepatitis/1550008/what-is-cytolytic-hepatitis
10050904
cytolytic hepatitis AE
HPO: HP_0004787
SIDER: C0919823
an inflammation AE that results in the inflammation of the colon
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22874621
10048983
cytomegalovirus colitis AE
a viral infection AE that is caused by cytomegalovirus
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/cytomegalovirusinfections.html
10011831
cytomegalovirus infection AE
HPO: HP_0004429
SIDER: C0010823
a skin AE that has an outcome of shedding of the dead skin cells from the scalp
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/dandruff
10011859
dandruff AE
HPO: HP_0001051
SIDER: C0221244
a surgery that performs a medical removal of dead, damaged, or infected tissue to improve the healing potential of the remaining healthy tissue
DJ, SS, YH, SJ
WEB: http://medical-dictionary.thefreedictionary.com/Debridement
WEB: http://www.surgeryencyclopedia.com/Ce-Fi/Debridement.html
10057612
10067806
debridement
a skin ulcer AE that has an outcome of localized injuries to the skin and/or underlying tissue usually over a bony prominence as a result of pressure
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/pressure+ulcer
10011985
decubitus ulcer AE
HPO: HP_0200042
SIDER: C0011127
a venous thrombosis that is characterized by a blood clot that forms in a vein deep in the body. Blood clots occur when blood thickens and clumps together. Most deep vein blood clots occur in the lower leg or thigh. They also can occur in other parts of the body.
DJ, SS, YH
DVT
WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/dvt/
Moved from Cardiac AE to thombosis AE by LB
10051055
deep vein thrombosis AE
HPO: HP_0004850
SIDER: C0149871
a psychiatric disorder AE that results in a decline in level of cognitive function
DJ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/delirium
10012218
delirium AE
CTCAE:E12898
NCIt:C2981
a tooth disorder AE that has an outcome of bacterial infection that causes demineralization and destruction of the hard tissues, resulting in dental cavities
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/dental+caries
10012318
dental caries AE
CTCAE: E10568
HPO: HP_0000670
NCIt: C52593
SIDER: C0011334
a sensory capability AE that results in a lower level of arousal than normal
DJ, SS, YH, MW
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23167919
10012373
depressed level of consciousness AE
CTCAE:E12625
HPO: HP_0004372
NCIt:C78253
SIDER: C0549249
a dermatitis ae that is characterized by the eruption of papules and pustules, typically on the face, scalp, upper chest and back.
DJ, SS, YH
acne AE
WEB: https://www.medify.com/conditions/acneiform-dermatitis
10012432
dermatitis acneiform AE
HPO: HP_0001051
SIDER: C0234894
a dermatitis ae that is characterized by an inflammatory skin disease with erythmea and scaling, that has an outcome of widespread scaling of the skin, often with itching, skin redness and hair loss
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001610.htm
10012455
dermatitis exfoliative AE
HPO: HP_0011123
SIDER: C0011606
a muscle AE that has an outcome of muscle weakness, inflammation, skin rash and difficulty swallowing
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001842/
10012503
dermatomyositis AE
a motor neuropathy AE that has an outcome of poor coordination
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001533.htm
10012557
developmental coordination disorder AE
an injury and procedural complication AE that results in the dislocation of a device
DJ, SS, YH
10064684
device dislocation AE
an injury and procedural complication AE that results in the expulsion (vomiting) of medical device from body
DJ, SS, YH
10012578
device expulsion AE
an injury and procedural complication AE that results in an infection related to medical device
DJ, SS, YH
10064687
device related infection AE
CTCAE: E11356
HPO: HP_0002719
NCIt: C79705
SIDER: C1619702
a coma AE which is induced by the condition that the patient has extremely high levels of sugar in the blood without ketones
DJ, SS, YH
diabetic hyperglycaemic coma AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000304.htm
10012668
diabetic hyperglycemic coma AE
a respiratory system AE that has an outcome of an abnormal hole in the diaphragm
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23288807
10012713
diaphragmatic hernia AE
HPO: HP_0000776
SIDER: C0019284
a paralysis AE that has an outcome of a paralyzed diaphragm
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/19452391
10012725
diaphragmatic paralysis AE
a diarrhea AE that has an outcome of rectal bleeding and bloody diarrhea
DJ, SS, YH
diarrhoea haemorrhagic AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/19292138
10012741
diarrhea hemorrhagic AE
HPO: HP_0002255
SIDER: C0151594
a diarrhea AE that has an outcome of diarrhea is caused by infection
DJ, SS, YH
diarrhoea infectious AE
10012742
diarrhea infectious AE
a cardiac disorder AE with an outcome of decline in performance of one or both ventricles of the heart during the time phase of diastole, when heart filling with incoming blood
DJ, SS, YH
WEB: http://encyclopedia.thefreedictionary.com/diastolic+dysfunction
10052337
diastolic dysfunction AE
a cardiac ventricular disorder AE that has an outcome of enlargement of a heart chamber that pumps blood away from the heart
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1721391/
10013012
dilatation ventricular AE
an adverse event with an outcome of worsening of the disease
DJ, SS, YH
10061818
disease progression AE
HPO: HP_0004738
SIDER: C0242656
a bone disorder AE that has an outcome of dislocation of vertebra
DJ, SS, YH
10013183
dislocation of vertebra AE
a sensory capability AE that results in the senses of time, direction, and recognition of people and places becoming difficult to distinguish
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/disorientation
10013395
disorientation AE
HPO: HP_0001289
SIDER: C0233407
a hematopoietic system AE with an outcome of a serious disorder in which proteins that control blood clotting become abnormally active
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000573.htm
10013442
disseminated intravascular coagulation AE
CTCAE: E10028
HPO: HP_0005521
NCIt: C2992
SIDER: C0012739
a behavior and neurological AE that results in a loss of attention
DJ, SS, YH
10013496
disturbance in attention AE
HPO: HP_0007018
SIDER: C0233414
a digestive system AE with an outcome of perforation of small sacs or pockets in the wall of the colon
DJ, SS, YH
WEB: http://www.webmd.com/digestive-disorders/diverticular-disease
10061820
diverticular perforation AE
a digestive system AE that has an outcome of infection and inflammation in the small, bulging sacs or pouches of the inner lining of the intestine
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001303/
10013538
diverticulitis AE
HPO: HP_0002253
SIDER: C0012813
a hemorrhage AE that has an outcome of bleeding in the intestine due to diverticulitis
DJ, SS, YH
diverticulitis intestinal haemorrhagic AE
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780263/
10013541
diverticulitis intestinal hemorrhagic AE
an adverse event that has an outcome of a decreased amount of the drug excreted by the body
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/drug+clearance
10049463
drug clearance decreased AE
an adverse drug event that results in the development of a dependence on the drug
DJ, SS, YH
10013663
drug dependence AE
HPO: HP_0000722
SIDER: C1510472
a skin AE that has an outcome of a range of adverse drugs reactions of the skin, most commonly rashes resembling measles
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/drug+eruption
10013687
drug eruption AE
a hypersensitivity AE that has an outcome of allergic reactions to certain drugs
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23192511
10013700
drug hypersensitivity AE
HPO: HP_0100326
SIDER: C0013182
a drug AE that has an outcome of lower threshold to the normal pharmacologic action of a drug
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/drug+intolerance
10061822
drug intolerance AE
a headache AE that has an outcome of headaches due to drug withdrawal
DJ, SS, YH
10013753
drug withdrawal headache AE
an adverse event that results in symptoms that occur after the discontinuation of the use of a certain drug
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/withdrawal
10013754
drug withdrawal syndrome AE
a skin AE that is characterized by epidermis that lacks moisture, has an outcome of fine lines, scaling and itching
DJ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/dry+skin
10013786
dry skin AE
CTCAE:E13623
HPO: HP_0000958
NCIt:C74592
SIDER: C0151908
a duodenum AE that has an outcome of a peptic ulcer, or a defect in the lining of the stomach or the first part of the small intestine, located in the duodenum
DJ, SS, YH
peptic ulcer AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/
10013836
duodenal ulcer AE
HPO: HP_0002588
SIDER: C0013295
a duodenal ulcer AE with an outcome of bleeding in an ulcer, or a defect, in the lining of the stomach or first part of the small intestine called the duodenum
DJ, SS, YH
duodenal ulcer haemorrhage AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/
10013839
duodenal ulcer hemorrhage AE
HPO: HP_0002588
SIDER: C0151966
a duodenal ulcer AE that has an outcome of perforation, or complete penetration, of an ulcer located in an area of the small intestine called the duodenum
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/
10013849
duodenal ulcer perforation AE
HPO: HP_0002588
SIDER: C0740401
a speech disorder that results in a motor speech disorder
DJ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/dysarthria
10013887
dysarthria AE
CTCAE:E12635
HPO: HP_0001260
NCIt:C79549
SIDER: C0013362
a behavioral and neurological AE that results in difficulty reading (mixing up letters)
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/dyslexia
10013932
dyslexia AE
HPO: HP_0010522
SIDER: C0476254
a speech disorder AE that results in disorders of voice
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/dysphonia
10013952
dysphonia AE
HPO: HP_0001618
SIDER: C1527344
a dyspnoea AE that has an outcome of shortness of breath during exercise, produces a sensation of not being able to get enough air
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22760109
10013971
dyspnoea exertional AE
HPO: HP_0002875
SIDER: C0231807
Dysuria AE is an urinary system AE that results in painful urination
JX, DJ, SS, YH
urination disorders AE
WEB: http://medical-dictionary.thefreedictionary.com/dysuria
排尿困难
10013990
dysuria AE
HPO: HP_0100518
SIDER: C0013428
a gustatory system AE which has an outcome of abrnormal or disturbed eating habits
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/eating+disorder
10014062
eating disorder AE
a female reproductive system AE that results in an ectopic pregnancy that occurs along with the use of an IUD
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/ectopic+pregnancy
10067037
ectopic pregnancy with intrauterine device AE
a skin AE that has an outcome of a long term skin disorder that involves scaly and itchy rashes
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001856/
10014184
eczema AE
HPO: HP_0000964
SIDER: C0013595
an abnormal fluid regulation AE that has an outcome of escape of a fluid into a part
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/effusion
10063045
effusion AE
a male reproductive system AE that has an outcome of a delay of ejaculation
DJ, SS, YH
10014325
ejaculation delayed AE
HPO: HP_0000022
SIDER: NA
a left ventricular dysfunction AE that has an outcome of decreased percentage of blood leaving the heart each time it contracts
DJ, SS, YH
WEB: http://www.mayoclinic.com/health/ejection-fraction/AN00360
10050528
ejection fraction decreased AE
CTCAE: E12142
NCIt: C83492
a cardiac function test abnormal AE that has an outcome of abnormal electrical activity in the heart
DJ, SS, YH, EB
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003868.htm
10014363
electrocardiogram result abnormal AE
an electrocardiogram result abnormal AE that has an outcome of an abnormal depolarization of the right and left ventricles of the heart that is detected on an electrocardiogram test
DJ, SS, YH, EB
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23238367
10014378
electrocardiogram qrs complex abnormal AE
an electrocardiogram result abnormal AE that has an outcome of a prolonged time between the start of the Q wave and the end of the T wave in the heart's electrical cycle; a biomarker for ventricular tachyarrhythmias
DJ, SS, YH, EB
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23275261
10014387
electrocardiogram qt prolonged AE
HPO: HP_0001657
SIDER: C0151878
an electrocardiogram result abnormal AE in which the T wave appears increased in amplitude and cresting at a point
DJ, SS, YH, EB
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23301064; http://www.medaphile.com/medical-dictionary/t-wave-peaked
10014396
electrocardiogram t wave peaked AE
a homeostasis AE that has an outcome of abnormalities in electrolytes (sodium, potassium, calcium)
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/electrolyte+imbalance
10014418
electrolyte imbalance AE
HPO: HP_0003111
SIDER: C0342579
a psychiatric disorder AE that results in an abnormal expression of emotions
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/emotional+disorder
10014551
emotional disorder AE
HPO: HP_0100851
SIDER: C0233459
an inflammation AE that occurs in the inside lining of the heart chambers and heart valves
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002088/
10014665
endocarditis AE
HPO: HP_0100584
SIDER: C0014118
a digestive system AE with an outcome of inflammation in the intestine, especially the small intestine
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/enteritis
10014866
enteritis AE
HPO: HP_0004387
SIDER: C0014335
a digestive system AE that has an outcome of disease in the digestive tract caused by infection
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/enterocolitis
10014893
enterocolitis AE
CTCAE: E10627
HPO: HP_0004387
NCIt: C79573
SIDER: C0014356
an digestive system AE that has an outcome of an infection by enteric viruses or enterotoxigenic bacterias, usually in the intestines, that presents with diarrhea, abdominal pain, perianal discomfort, incontinence and hemorrhage.
DJ, SS, YH
WEB: http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-0792-2..50022-5--cesec139&isbn=978-1-4377-0792-2&type=bookPage&from=content&uniqId=376758653-2
10058838
enterocolitis infectious AE
an eosinophil count abnormal AE that has an outcome of an increased amount of eosinophils, a type of white blood cell that becomes active with allergic diseases and infections
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003649.htm
10014945
eosinophil count increased AE
HPO: HP_0001880
SIDER: C2240374
a hematopoietic system AE that has an outcome of higher than normal levels of eosinophils, a type of white blood cell
DJ, SS, YH
WEB: http://www.mayoclinic.com/health/eosinophilia/MY00399
10014950
eosinophilia AE
HPO: HP_0001880
SIDER: C0014457
a male reproductive system AE that results in the inability to develop/maintain an erection of penis
DJ, SS, JX, LW, YH, MW
astyphia AE
impotence AE
WEB: http://en.wikipedia.org/wiki/Erectile_dysfunction
阳痿/勃起功能障碍
10061461
erectile dysfunction AE
CTCAE:E13088
HPO: HP_0008652
NCIt:C3133
SIDER: C0242350
a skin AE that has an outcome of an infection caused by a Streptococcus bacteria that causes blisters, fever and skin lesion and sores
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001643/
10015145
erysipelas AE
HPO: HP_0001055
SIDER: C0014733
a psoriasis AE that has an outcome of psoriasis that affects all sites on the body
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/psoriatic+erythroderma
10015278
erythrodermic psoriasis AE
a bacterial infection AE with an outcome of invasion by Escherichia coli bacteria, commonly found in the lower intestine and can cause serious food poisoning, but can also be found in various parts of body
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/escherichia+coli
10061126
escherichia infection AE
a microbiology and serology investigation result abnormal AE that has an outcome of a positive escherichia test
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/Escherichia
10070090
escherichia test positive AE
an urinary tract infection AE that has an outcome of infection caused by E. coli bacteria
DJ, SS, YH
WEB: http://www.medicinenet.com/urine_infection/article.htm
10052238
escherichia urinary tract infection AE
a connective tissue AE that has an outcome of excess perfused, fibrous connective tissue that replaces a fibrin clot in healing wounds.
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/19594571
10063560
excessive granulation tissue AE
a rash AE that has an outcome of erythema, desquamation, scaling, itching of the skin and loss of hair
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/exfoliative+dermatitis
10064579
exfoliative rash AE
a congenital abnormality that results in a weakness of the baby's abdominal wall where the umbilical cord joins it. This weakness allows the abdominal contents to protrude outside the abdominal cavity
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/exomphalos
10015677
exomphalos AE
HPO: HP_0001539
SIDER: C1306503
an injury and procedural complication AE that results in the patient being exposed to a contaminated device
DJ, SS, YH
10068515
exposure to contaminated device AE
a procedural complication AE that results in the patient being exposed to a toxic agent
DJ, SS, YH
10053487
exposure to toxic agent AE
an abscess AE that results in a collection of pus between a person's skull and dura
DJ, SS, YH
WEB: http://www.meb.uni-bonn.de/dtc/primsurg/docbook/html/x1217.html
10061846
extradural abscess AE
a paresis AE that results in a partial loss of voluntary movement in their extraocular muscles
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22824489
10015829
extraocular muscle paresis AE
CTCAE: E10367
NCIt: C78286
coagulopathy AE results in the impairment of blood to clot causing ecessive or prolonged bleeding.
SJ, YH
bleeding disorder
clotting disorder
WEB: http://en.wikipedia.org/wiki/Coagulopathy
10009802
coagulopathy AE
a hemorrhage AE that has an outcome of hemorrhage occuring in the blood vessels in the eye
DJ, SS, YH
eye haemorrhage AE
subconjunctival haemorrhage AE
WEB: http://www.webmd.com/eye-health/bleeding-in-the-eye
10015926
eye hemorrhage AE
HPO: HP_0011885
SIDER: C0015402
a eye disorder AE that has an outcome of swelling in the tissues around the eyes, called the orbits, caused by fluid buildup
DJ, SS, YH
perioribtal puffiness AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21115963
10015967
eye swelling AE
an eye edema AE that has an outcome of swelling in either or both the lower and upper eyelids, due to fluid buildup or inflammation in the delicate tissues surrounding the eye.
DJ, SS, YH
eyelid oedema AE
WEB: http://www.localhealth.com/article/eyelid-swelling
10015993
eyelid edema AE
HPO: HP_0100539
SIDER: C0162285
A pregnancy, neonatal and perinatal AE that displays the result of failure to thrive (FTT), which refers to a baby or child that is not developing as well as desired.
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000991.htm
WEB: http://www.stanfordchildrens.org/en/topic/default?id=failure-to-thrive-90-P02297
10016165
failure to thrive AE
HPO: HP_0001531
SIDER: C0015544
a behavior and neurological AE that has an outcome of patient falling
DJ, SS, YH
10016173
fall AE
CTCAE: E11687
HPO: HP_0002359
NCIt: C50558
SIDER: C0085639
a behavior and neurological AE that results in the extreme fear of needles
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23225704
10068298
fear of needles AE
a hematopoietic system AE that has an outcome of inadequate blood cell formation by bone marrow accompanied by a fever
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Bone+marrow+aplasia
10053213
febrile bone marrow aplasia AE
a fever AE that has an outcome of an infection along/because of a fever
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/febrile
10051998
febrile infection AE
a neutropenia AE, generally a complication of chemotherapy, that has an outcome of an abnormally low neutrophil granulocyte count, accompanied by fever
DJ, SS, YH
neutropenic sepsis AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23303687
10016288
febrile neutropenia AE
CTCAE: E10033
HPO: HP_0001875
NCIt: C35665
SIDER: C0746883
an injury and procedural complication AE that has an outcome of an complication due to the use of enteral feeding tube
DJ, SS, YH
enteral feeding AE
WEB: http://www.thirdage.com/hc/p/197842/what-is-tube-feeding
10056661
feeding tube complication AE
a sensory capabilty AE that results in the patient feeling different than normal after a medical intervention such as taking drug
DJ, SS, YH
10016322
feeling abnormal AE
HPO: HP_0010870
SIDER: C1443060
Feeling hot AE is a feeling abnormal AE that a patient feels hot.
DJ, SS, YH
10016334
feeling hot AE
a hypoaesthesia AE that has an outcome of a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli in the oral area
SS, YH
hypoaesthesia oral AE
WEB: http://en.wikipedia.org/wiki/Hypoesthesia
10057371
hypoesthesia oral AE
HPO: HP_0010830
SIDER: C0521592
a fistula AE that has an outcome of discharge that occurs as the result of the connection between two body cavities
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed?term=fistula%20discharge%20%5BTI%5D
10067143
fistula discharge AE
an abnormal fluid regulation AE with an outcome of decrease in ingestion of water or other fluids
DJ, SS, YH
10056291
fluid intake reduced AE
a hematopoietic system AE that has an outcome of too much fluid in the blood, can occur due to increase in total body sodium
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22827112
10016803
fluid overload AE
a hyperplasia AE that has an outcome of a benign tumor in the liver
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/focal+nodular+hyperplasia
10052285
focal nodular hyperplasia AE
a congenital abnormality disorder AE that has an outcome of a decreased heart rate in a fetus
DJ, SS, YH
foetal heart rate deceleration AE
10058322
fetal heart rate deceleration AE
a skin AE with the outcome disease involving of one more more hair follicles, commonly displays rash, itching and pustules near the hair follicles
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001826/
10016936
folliculitis AE
a respiratory system AE that has an outcome of a decreased volume of air expired from the lungs
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/forced+expiratory+volume
10016987
forced expiratory volume decreased AE
CTCAE: E12156
NCIt: C50524
a bone disorder AE that has an outcome of fracture located in the arm
DJ, SS, YH
10016997
forearm fracture AE
a bone disorder AE that has an outcome of complete or incomplete break in a bone resulting from the application of excessive force
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Fractures
10017076
fracture AE
CTCAE: E11703
NCIt: C3046
a full blood count abnormal AE that has an outcome of a decrease in full blood cell count
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/full+blood+count
10017413
full blood count decreased AE
a digestive system AE that has an outcome of inflammation in the esophagus due to fungus
DJ, SS, YH
fungal oesophagitis AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002138/
10049656
fungal esophagitis AE
a digestive system AE that has an outcome of an abnormal enlargement in the size of the gallbladder
DJ, SS, YH
10062693
gallbladder enlargement AE
a digestive system AE that has an outcome of an abnormal hole in the patient's gallbladder
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/gallbladder+perforation
10017639
gallbladder perforation AE
CTCAE: E11208
NCIt: C78309
a digestive system AE that has an outcome of an abnormal growth (accumulation of mucous membrane tissue) in the gallbladder
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/19556839
10049704
gallbladder polyp AE
an arrhythmia AE that results in an abnormal heart sound
DJ, SS, YH
WEB: http://circ.ahajournals.org/content/20/6/1053.full.pdf
10017648
gallop rhythm present AE
a liver related investigation result abnormal AE that has an outcome of an abnormal level of gamma-glutamyltransferase (GGT); GGT is involved in the transfer of amino acids across the cellular membrane
DJ, SS, YH, EB
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003458.htm
10017688
gamma-glutamyltransferase level abnormal AE
a gamma-glutamyltransferase level abnormal AE that has an outcome of an increase in gamma-glutamyltransferase enzyme presence in the liver
DJ, SS, YH, EB
GGT increased
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23258530
10017693
10056910
gamma-glutamyltransferase level increased AE
CTCAE: E12161
NCIt: C26943
a gastric disorder AE that has an outcome of cancer that starts in the stomach
DJ, SS, YH
10017758
gastric cancer AE
HPO: HP_0006753
SIDER: C0024623
a tumor AE that has an outcome of cancer in the stomach
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/stomach+cancer
10061968
gastric neoplasm AE
a gastric disorder AE that has an outcome of a defect in the lining of the stomach
DJ, SS, YH
胃溃疡
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001255/
10017822
gastric ulcer AE
CTCAE: E10727
HPO: HP_0002592
NCIt: C3388
SIDER: C0038358
a gastric disorder AE that has an outcome of inflammation in the lining of the stomach
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002135/
10017853
gastritis AE
CTCAE: E10733
HPO: HP_0005263
NCIt: C26780
SIDER: C0017152
a gastritis AE that has an outcome of inflammation in the stomach mucosa
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/2789800
10017860
gastritis atrophic AE
a gastritis AE that has an outcome of gastric mucosal erosion caused by damage to mucosal defences
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/gastritis
10017865
gastritis erosive AE
HPO: HP_0005263
SIDER: C2243088
ischemic colitis AE is a gastrointestinal disorder AE that results in injury and inflammation of the large intestine due to inadequate blood supply.
SJ, YH
WEB: http://en.wikipedia.org/wiki/Ischemic_colitis
10009896
ischemic colitis AE
a gastroenteritis AE that has an outcome of disease caused by the norovirus
DJ, SS, YH
WEB: http://www.cdc.gov/ncidod/dvrd/revb/gastro/faq.htm
10068189
gastroenteritis norovirus AE
a gastroenteritis AE that has an outcome of disease due to radiation
DJ, SS, YH
10017912
gastroenteritis radiation AE
a digestive system AE that results in mucosal damage caused by acid from stomach coming up to the esophagus
DJ, SS, YH
GERD AE
esophageal reflux AE
gastrooesophageal reflux disease AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23301861
10017885
10066874
gastroesophageal reflux disease AE
CTCAE: E10739
NCIt: C26781
a gastrointestinal disorder AE with an outcome of infection in the digestive tract caused by bacteria, viruses or parasites
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Gastrointestinal+infection
10017964
gastrointestinal infection AE
HPO: HP_0004798
SIDER: C1264613
a gastrointestinal disoder AE that has an outcome of an injury in the gastrointestinal area
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23207874
10061172
gastrointestinal injury AE
a gastrointestinal disoder AE that has an outcome of premature death in cells of living tissue in the stomach and intestines
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/necrosis
10017982
gastrointestinal necrosis AE
an adverse event induced by administration of a bupropion drug
YH
bupropion-induced adverse event
a gastrointestinal disorder AE that results in a hole in the wall of the esophagus, stomch, small intestine, large bowel, rectum or gallbladder
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001282/
10018001
gastrointestinal perforation AE
HPO: HP_0011024
SIDER: C0151664
a tumor AE that has an outcome of a tumor in the gastrointestinal tract, thought to grow from specialized cells found in the tract called interstitial cells of Cajal
DJ, SS, YH
gastrointestinal stromal tumour AE
WEB: http://ghr.nlm.nih.gov/condition/gastrointestinal-stromal-tumor
10051066
gastrointestinal stromal tumor AE
HPO: HP_0007378
SIDER: C0238198
a gastrointestinal disorder AE that has an outcome of poison affecting the stomach and/or intestinal tracts, often accompanied by abdominal pain, diarrhea and vomiting
DJ, SS, YH
WEB: http://www.theodora.com/drugs/valcyte_tablets_roche_laboratories.html
10059024
gastrointestinal toxicity AE
HPO: HP_0011024
SIDER: C1142499
a cytogenetic investigation result abnormal AE that has an outcome of a positive test for gene mutation, deletions and duplications that could indicate large disease risk
DJ, SS, YH, EB
WEB: https://www.duchenneconnect.org/index.php?option=com_content&view=article&id=346&Itemid=392&lang=en
10063478
gene mutation identification test positive AE
a systematic adverse event that has an outcome of worsening of physical health
DJ, SS, YH
10049438
general physical health deterioration AE
an edema AE that has an outcome of edema where causes of edema are generalized to the whole body, can cause edema in multiple organs and peripherally
DJ, SS, YH
generalised oedema AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/16491771
10018092
generalized edema AE
HPO: HP_0007430
SIDER: C0151603
a skin ulcer AE that results in an ulcer in the genital area usually resulting from an STD
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23064541
10018180
genital ulceration AE
HPO: HP_0003249
SIDER: C0151281
an abscess AE that has an outcome of a gum-line of the teeth due to pus-filled sacs
DJ, SS, YH
WEB: http://www.mdguidelines.com/gingival-abscess
10052359
gingival abscess AE
a digestive system AE that has an outcome of abnormally enlarged, bulging or protruding gums
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003066.htm
10018291
gingival swelling AE
a kidney disorder AE that has an outcome of a decreased rate per minute at which the blood passes through the glomeruli or the filters in the kidneys
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007305.htm
10018358
glomerular filtration rate decreased AE
HPO: HP_0000083
SIDER: C0853068
a digestive system AE that has an outcome of a burning or tingling sensation on the lips, tongue or entire mouth
DJ, SS, YH
burning tongue AE
WEB: http://medical-dictionary.thefreedictionary.com/glossodynia
10018388
glossodynia AE
HPO: HP_0000157
SIDER: C0017672
a glycosylated hemoglobin level abnormal AE that has an outcome of decreased levels of glycosylated hemoglobin in the blood
DJ, SS, YH, EB
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23015148
10018482
glycosylated hemoglobin level decreased AE
a hypothesis textual entity that represents a belief in likelihood of causal connection between process 1 and process 2.
Barry Smith, Yu Lin, Oliver He
belief in likelihood of causal connection between two processes
an infection AE that results in a graft infection
DJ, SS, YH
10056559
graft infection AE
a sensorimotor painful neuropathy AE which has an outcome of distal sensory neuropathy characterized by damage to sensory and motor nerves
distal sensorimotor painful neuropathy
a microbiology and serology investigation result abnormal AE that has an outcome of detection of gram-positive bacteria
DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/gram+stain
10018656
gram stain positive AE
a nervous system AE that results in a generalized seizure that affects the entire brain
DJ, SS, YH, SJ
tonic seizure
WEB: http://www.mayoclinic.com/health/grand-mal-seizure/DS00222
10018659
grand mal convulsion AE
HPO: HP_0002197
SIDER: C0014549
a granulocyte count abnormal AE that has an outcome of compromise to the immune system where the number of neutrophil granulocytes, a type of white blood cell, is lower than the normal range of ~1700 per microliter.
DJ, SS, YH, EB
neutropenia AE
10018681
granulocyte count decreased AE
a belief in likelihood of causal connection between two processes that represents a belief in likelihood of causal connection between medical intervention m and adverse event e.
Barry Smith, Yu Lin, Oliver He
belief in likelihood of causal connection between medical intervention and adverse event
a hematopoietic system AE that has an outcome of a marked decrease in number of granulocytes, a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms
DJ, SS, YH
WEB: http://www.medterms.com/script/main/art.asp?articlekey=8817
10018687
granulocytopenia AE
a psorisis AE that has an outcome of psoriasis that appears on the back and extremities of the patients
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/20860740
10018797
guttate psoriasis AE
a disposition that represents the likelihood of the occurrence of an adverse event after a medical intervention.
YH
adverse side effect
adverse effect
a male reproductive system AE that has an outcome of abnormal development of large mammary glands in males resulting in breast enlargement
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/gynecomastia
10018800
gynaecomastia AE
HPO: HP_0000771
SIDER: C0018418
an information content entity that represents evidence for indicating the causal association between an adverse event and a medical intervention.
YH
evidence bearing on adverse event causality
adverse event causality evidence
a vomiting AE that results in the vomiting of blood
DJ, SS, YH
haematemesis AE
WEB: http://medical-dictionary.thefreedictionary.com/hematemesis
10018830
hematemesis AE
HPO: HP_0002248
SIDER: C0018926
a digestive system AE that has an outcome of the passage of bloody stools
DJ, SS, YH
haematochezia AE
WEB: http://medical-dictionary.thefreedictionary.com/hematochezia
10018836
hematochezia AE
HPO: HP_0002573
SIDER: C0018932
a hematocrit abnormal AE with an outcome of decreased volume percentage of red blood cells in blood
DJ, SS, YH, EB
haematocrit decreased AE
WEB: http://medical-dictionary.thefreedictionary.com/hematocrit
10018838
hematocrit decreased AE
an infection AE that has an outcome of infection in a hematoma
DJ, SS, YH
haematoma infection AE
WEB: http://medical-dictionary.thefreedictionary.com/hematoma
10051564
hematoma infection AE
a hematopoietic system AE that has an outcome of toxins that destroy red blood cells, disrupt blood clotting, and/or cause organ degeneration and generalized tissue damage
DJ, SS, YH
haematotoxicity AE
10061188
hematotoxicity AE
A conduction system disorder AE that is a condition in which ventricular contraction is not completely synchronized due to a block in conduction of an electrical impulse to the ventricles; in LBBB, right ventricular endocardial activation begins before, and is often completed before, initiation of left ventricular endocardial activation; benign LBBB is rare; preexisting LBBB in absence of clinical evidence of heart disease is rare; newly acquired LBBB has a 10-fold ↑ in mortality Clinical Generally asymptomatic, or absent or diminished 1st heart sound–HS and reversed splitting of 2nd HS EKG Lead V1–QS or rS; lead V6–late intrinsicoid deflection, monophasic R; lead I–monophasic R Management Pacemaker, if syncope or significant arrhythmias Followup Telemetry PRN.
YH, SS
LBBB
left bundle branch block
WEB: http://medical-dictionary.thefreedictionary.com/left+bundle+branch+block
10006580
bundle branch block left AE
HPO: HP_0011713
SIDER: C0023211
a red blood cell profile abnormal AE that has an outcome of an abnormal count of hemoglobin, or iron-containing oxygen-transport metalloprotein in red blood cells
DJ, SS, YH, EB
haemoglobin abnormal AE
WEB: http://medical-dictionary.thefreedictionary.com/hemoglobin
10018879
hemoglobin level abnormal AE
a vaccination that uses an influenza vaccine
YH
influenza vaccine administration
an adverse effect that occurs after a drug administration: an appreciably harmful or unpleasant reaction resulting from an intervention related to the use of a medicinal product
YH, SJ
http://www.ncbi.nlm.nih.gov/pubmed/11072960
10061623
adverse drug effect
a hematopoietic system AE that has an outcome of hemolytic anemia, acute kidney failure and a low platelet count
DJ, SS, YH
haemolytic uraemic syndrome AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23307876
10018932
10019515
hemolytic uremic syndrome AE
CTCAE: E10043
HPO: HP_0005575
NCIt: C75545
SIDER: C0019061
a respiratory system AE that has an outcome of expectoration of blood or blood-stained sputum from the bronchi, larynx, trachea or lungs
DJ, SS, YH
haemoptysis AE
WEB: http://medical-dictionary.thefreedictionary.com/hemoptysis
10018964
hemoptysis AE
HPO: HP_0002105
SIDER: C0019079
a nervous system AE that has an outcome of accumulation of blood within the cranial vault
DJ, SS, YH
haemorrhage intracranial AE
WEB: http://emedicine.medscape.com/article/1163977-overview
10018985
hemorrhage intracranial AE
HPO: HP_0002170
SIDER: C0151699
a female reproductive system AE that results in a 'blood cyst' where the walls of ovarian cysts are lined with blood vessels, which when rupture fill the cyst with blood.
DJ, SS, YH
haemorrhagic ovarian cyst AE
10060781
hemorrhagic ovarian cyst AE
a surgery that removes hemorroids
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/hemorrhoid
10059624
haemorrhoid operation
an information content entity that represents the outcome of the evidences used for seeking the causal association between an adverse event and a medical intervention.
YH
outcome of adverse event causality evidence
a digestive system AE that has an outcome of bleeding in hemorrhoids, vascular structures in the anal canal which help with stool control
DJ, SS, YH
haemorrhoidal haemorrhage AE
WEB: http://medical-dictionary.thefreedictionary.com/hemorrhoid
10054787
10060640
hemorrhoidal hemorrhage AE
CTCAE: E10767
NCIt: C78337
a digestive system AE that has an outcome of painful, swollen veins in the lower portion of the rectum or anus
DJ, SS, YH
haemorrhoids AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001337/
10019022
10019611
hemorrhoids AE
CTCAE: E10773
HPO: HP_0004296
NCIt: C26792
a lung disorder AE that has an outcome of a collection of blood in the space between the chest wall and the lung
DJ, SS, YH
haemothorax AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001183/
10019027
hemothorax AE
a hair AE that has an outcome of abnormal growth of facial or body hair
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Hair+growth
10019044
hair growth abnormal AE
HPO: HP_0010720
SIDER: C0232409
an information content entity that represents a score or probability that an adverse event is likely caused (induced) by a medical intervention.
YH
adverse event causal association score
adverse event causality assessment score
adverse event causality score
a hemoglobin level abnormal AE with an outcome of decrease in amount of iron-containing oxygen-transport metalloprotein in the red blood cells
DJ, SS, YH, EB
haemoglobin decreased AE
WEB: http://medical-dictionary.thefreedictionary.com/hemoglobin
10018884
hemoglobin level decreased AE
a liver/biliary system AE that has an outcome of a chronic degenerative disease in which normal liver cells are damaged and then replaced by scar tissue
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Hepatic+cirrhosis
10019641
hepatic cirrhosis AE
HPO: HP_0001394
SIDER: C0023890
a lab test abnormal AE that has an outcome of an increase in amount of hepatic enzyme in body, a liver/biliary system AE that has an outcome of elevated levels of liver enzymes, commonly ALT and AST, may indicate inflammation or damage to liver cells
DJ, SS, YH
WEB: http://www.mayoclinic.com/health/elevated-liver-enzymes/MY00508
10060795
hepatic enzyme increased AE
HPO: HP_0002910
SIDER: C0235996
a liver/biliary system AE that has an outcome of the inability of the liver to perform its normal synthetic and metabolic function
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/liver+failure
10019663
hepatic failure AE
CTCAE: E11211
HPO: HP_0001399
NCIt: C26922
SIDER: C0085605
a liver/biliary system AE that results in incorrect blood flow to liver
DJ, SS, YH
WEB: http://archinte.jamanetwork.com/article.aspx?articleid=571358
10019680
hepatic infarction AE
an adverse effect that occurs after administration of a vaccine.
YH
adverse vaccine effect
a liver/biliary system AE with an outcome of a lesion, an abnormality in the tissue caused by disease or trauma, located in the liver
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21275132
10061998
hepatic lesion AE
a liver/biliary system AE that has an outcome of death of hepatic parenchyma which may be single cell, or multicell in piecemeal, focal, periacinar, midzonal, periportal or paracentral locations
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/hepatic+necrosis
10019692
hepatic necrosis AE
CTCAE: E11221
HPO: HP_0002605
NCIt: C78340
SIDER: C0151798
a tumor AE that has an outcome of a malignant tumor in the liver
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23302476
10019695
hepatic neoplasm AE
HPO: HP_0002896
SIDER: C0023903
Acanthosis nigricans AE is a skin AE that is a brown to black, poorly defined, velvety hyperpigmentation of the skin. It is usually found in body folds, such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead, and other areas.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Acanthosis_nigricans
黑棘皮病
10000350
acanthosis nigricans AE
a hepatitis AE that has an outcome of irritation and swelling of the liver due to infection with the heptitis B virus
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001324/
10019731
hepatitis B AE
HPO: HP_0006562
SIDER: C0019163
a hepatitis AE that has an outcome of liver inflammation due to a hepatitis viral infection
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/viral+hepatitis
10019799
hepatitis viral AE
CTCAE: E11410
HPO: HP_0006562
NCIt: C35124
SIDER: C0042721
a liver/biliary system AE that has an outcome of swelling of the liver
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003275.htm
10019842
hepatomegaly AE
HPO: HP_0002240
SIDER: C0019209
a liver damage AE that has an outcome of chemically driven liver damage
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/hepatotoxicity
10019851
hepatotoxicity AE
an influenza vaccine administration that uses Afluria
YH
Afluria administration
an inflammation AE that has an outcome of an inflammatory infiltrate around the eccrine sweat gland
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/hidradenitis
10020040
hidradenitis AE
an immune system disorder AE that has an outcome of abnormal proliferation of histiocytes, a type of immune cell that eats foreign substances
DJ, SS, YH
histiocytosis haematophagic AE
WEB: http://www.medterms.com/script/main/art.asp?articlekey=11478
10048595
histiocytosis hematophagic AE
a fungal infection AE that results in an infection that occurs from breathing in the spores of the fungus Histoplasma Capsulatum
DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001082.htm
10020144
histoplasmosis disseminated AE
A surgery where incisions are made through a woman's abdomen and uterus to deliver her baby.
YH, SS
cesarean section
WEB: http://medical-dictionary.thefreedictionary.com/cesarean+section
10006924
caesarean section
a urinary system AE that has an outcome of distension and dilation of the renal pelvis and calyces, usually caused by the osbtruction of urine flow from the kidney
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/hydronephrosis
10020524
hydronephrosis AE
HPO: HP_0000126
SIDER: C0020295
a congenital abnormality AE that results in the yellowing of the skin of infants
DJ, SS, YH
hyperbilirubinaemia neonatal AE
WEB: http://medical-dictionary.thefreedictionary.com/neonatal+jaundice
10020580
hyperbilirubinemia neonatal AE
a blood calcium abnormal AE that has an outcome of an elevated calcium level in the blood, above normal range of 9-10.5 mg/dL
YH, MW
hypercalcaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/hypercalcemia
10020583
10020587
hypercalcemia AE
CTCAE: E12270
HPO: HP_0003072
NCIt: C3112
SIDER: C0020437
a skin AE that results in excess perspiration
DJ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/hyperhidrosis
10020642
hyperhidrosis AE
CTCAE:E13645
HPO: HP_0000975
NCIt:C78345
SIDER: C0020458
a blood potassium abnormal AE that has a lab test outcome of an abnormally increased concentration of potassium in blood
YH, MW
hyperkalaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/hyperkalemia
10020646
10020647
hyperkalemia AE
CTCAE: E12282
HPO: HP_0002153
NCIt: C37968
SIDER: C0020461
toxin-induced cardiomyopathy AE
cocaine-induced cardiomyopathy AE
an abnormal fluid regulation AE that has an outcome of an excessive secretion of the parathyroid hormone by the parathyroid gland
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23267748
10020708
hyperparathyroidism secondary AE
HPO: HP_0003106
SIDER: C0020503
a paresis AE that shows muscle weakness affecting the lower limbs.
JX, YH
WEB: http://www.merriam-webster.com/medical/paraparesis
下肢轻瘫
10033885
paraparesis AE
a systemic hypertension AE that has an outcome of hypertension with systolic blood pressure >180 mm Hg or a diastolic pressure >120 mm, can be further classified as hypertensive urgency or hypertensive emergency depending on end-organ involvement
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/20160537
10020802
hypertensive crisis AE
HPO: HP_0000875
SIDER: C0020546
a hematopoietic system AE that has an outcome of high blood levels of triglycerides, abundant fatty molecules
DJ, SS, YH, MW
hypertriglyceridaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/hypertriglyceridemia
10020869
10020870
hypertriglyceridemia AE
CTCAE: E12299
HPO: HP_0002155
NCIt: C37971
SIDER: C0020557
an arthritis AE that has an outcome of uric acid building up in blood and causes joint inflammation
DJ, SS, YH, MW
gout AE
hyperuricaemia AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001459/
10020903
10020907
hyperuricemia AE
CTCAE: E12305
HPO: HP_0002149
NCIt: C3961
SIDER: C0740394
a blood albumin abnormal AE that shows an abnormally low level of albumin protein in the blood.
DJ, SS, YH
hypoalbuminaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/hypoalbuminemia
10020942
10020943
hypoalbuminemia AE
CTCAE: E12310
HPO: HP_0003073
NCIt: C37972
SIDER: C0239981
a blood calcium abnormal AE that has an outcome of abnormally low calcium levels, can present with convulsions, arrythmias, tetany and numbness
YH, MW
hypocalcaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/hypocalcemia
低血钙
10020947
10020949
hypocalcemia AE
CTCAE: E12316
HPO: HP_0002901
NCIt: C37973
SIDER: C0020598
a blood carbon dioxide abnormal AE in which the levels of carbon dioxide in the blood is abnormally low.
DJ, SS, YH, MW
WEB: https://en.wikipedia.org/wiki/Hypocapnia
10020952
hypocapnia AE
UMLS CUI: C0085383
a glucose homeostasis AE that results in a abnormally diminished content of glucose in the blood
DJ, SS, YH, MW
hypoglycaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/hypoglycemia
10020993
10021005
hypoglycemia AE
CTCAE: E12322
HPO: HP_0005969
NCIt: C3126
SIDER: C0020615
a neurological, special senses and psychiatric investigation result abnormal AE that is the abnormal result of the recording of the level of consciousness in a person after a brain injuiry.
YH, SJ
WEB: http://www.brainline.org/content/2010/10/what-is-the-glasgow-coma-scale.html
10069709
Clinicians use the Galscow coma scale to rate the best eye opening response, the best verbal response, and the best motor response an individual makes. The final GCS score or grade is the sum of these numbers.
Glascow coma scale abnormal AE
a blood magnesium abnormal AE that has an outcome of an abnormal concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors.
YH, MW
hypomagnesaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/Hypomagnesaemia
10021027
10021028
hypomagnesemia AE
CTCAE: E12333
HPO: HP_0002917
NCIt: C37975
SIDER: C0151723
UMLS CUI: C0151723
a conduction system disorder AE that refers to the slow conduction of electricity through ventricular walls of the heart.
SS
IVCD
BOOK: Taber's Cyclopedic Medical Dictionary;2005, p1134
WEB: http://connection.ebscohost.com/c/reference-entries/21232773/intraventricular-conduction-delay
intraventricular conduction delay AE
a gustatory system AE with an outcome of reduced food intake
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/hypophagia
10063743
hypophagia AE
a hematopoietic system AE that has an outcome of abnormally low phosphate levels, can present with muscle dysfunction, white cell dysfunction, pulp chambers and mental status changes
DJ, SS, YH, MW
hypophosphataemia AE
WEB: http://medical-dictionary.thefreedictionary.com/hypophosphatemia
10021058
10021059
hypophosphatemia AE
CTCAE: E12344
HPO: HP_0008285
NCIt: C37977
SIDER: C0085682
UMLS CUI: C0085682
an endocrine system AE with the outcome of the thyroid gland does not make enough thyroid hormone
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001393/
10021114
hypothyroidism AE
CTCAE: E10334
HPO: HP_0008245
NCIt: C26800
SIDER: C0020676
a cardiovascular disorder AE that is characterized by decreased blood plasma volume
DJ, SS, YH
hypovolaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/hypovolemia
10021137
hypovolemia AE
HPO: HP_0011106
SIDER: C0546884
an influenza vaccine administration that uses Flumist
YH
Flumist administration
a cardiovascular disorder AE that has the outcome of severe blood and fluid loss that makes the heart unable to pump enough blood to the body, often leads to organ failure
DJ, SS, YH
hypovolaemic shock AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000167.htm
10021138
hypovolemic shock AE
HPO: HP_0011106
SIDER: C0020683
a digestive system AE that has an outcome of holes in the ileum of the small intestine
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/ileum
10021305
ileal perforation AE
a digestive system AE that has an outcome of a partially or completely blocked bowel
DJ, SS, YH
intestinal obstruction AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001306/
10021328
ileus AE
CTCAE: E10812
HPO: HP_0002595
NCIt: C37979
SIDER: C1258215
a digestive system AE that has an outcome of intestinal blockage in the absence of an actual physical obstruction, can be caused by a malfunction in nerves and muscles in the intestine
DJ, SS, YH
WEB: http://www.localhealth.com/article/paralytic-ileus
10021333
ileus paralytic AE
HPO: HP_0002590
SIDER: C0030446
A cardiac disorder AE that has an outcome of an abnormal enlargement of the heart
YH, SS
WEB: http://medical-dictionary.thefreedictionary.com/cardiomegaly
added MedDRA term LB
10007632
cardiomegaly AE
HPO: HP_0001640
SIDER: C0018800
a drug adverse event that has an outcome of decreased levels of immunosuppressant drugs in the patient's body
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Immunosuppresant
10062014
immunosuppressant drug level decreased AE
an immune system disorder AE that has an outcome of reduced or absent immune response
DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001821/
10062016
immunosuppression AE
an injury AE that has an outcome of impairment to the process of restoring a state of soundness to any interupption in the continuity of external surfaces of the body
DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/wound+healing
10021519
impaired healing AE
HPO: HP_0001058
SIDER: C0151692
a pain AE that has an outcome of pain at the site of an implant
DJ, SS, YH
10063782
implant site pain AE
an outcome of adverse event causality evidence that has an outcome of no evidence bearing on a AE causal relation.
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32.
no evidence bearing on an adverse event causal relation
a respiratory system AE that has an outcome of increased thickness of the secretions of the bronchi
DJ, SS, YH
10054761
increased viscosity of bronchial secretion AE
an infection AE that results in infection by a parasite
DJ, SS, YH
10021857
infection parasitic AE
HPO: HP_0002719
SIDER: C0747256
an immune system disorder AE that has an outcome of increased susceptibility to infection
DJ, SS, YH
10021866
infection susceptibility increased AE
HPO: HP_0002719
SIDER: C0236171
an infection AE that has an outcome of an increase in severity of cystic fibrosis in the patient
SZ, DJ, SS, YH
10070608
infective pulmonary exacerbation of cystic fibrosis AE
a medical intervention that is used for preventive purpose
YH
preventive intervention
a immune system AE that results in an allergic reaction to foreign protein, but can also be caused by cytokine release.
SZ, DJ, SS, YH
WEB: http://www.ons.org/Publications/VJC/media/ons/docs/publications/VJC/vjc-apr10cjon.pdf
10051792
10053483
infusion related reaction AE
CTCAE: E11127
NCIt: C78361
an extravasation AE that has an outcome of leaking of pharmacologic or biological substance from infusion site into surrounding tissue. Symptoms include induration, erythema, swelling, burning sensation and pain
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/extravasation
10064774
infusion site extravasation AE
CTCAE: E11133
NCIt: C78362
Infection AE that results in the patient gets infected at the sight of an infusion
SZ, DJ, SS, YH
10054997
infusion site infection AE
Rash AE that results in patient has a rash at the site of infusion
SZ, DJ, SS, YH
10059830
infusion site rash AE
an allergy AE that has an outcome of infusion site allergic reaction
SZ, DJ, SS, YH
10054996
infusion site reaction AE
a nail disorder AE that results in a nail growing into the sides of the paronychium
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/ingrowing+nail
10022013
ingrowing nail AE
a skin discoloration AE that results in a discoloration of the skin at the site of injection of the drug
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/macule
10067255
injection-site macule AE
Inflammation AE that results in swelling of the veins at the site of drug injection
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/phlebitis
10022090
injection-site phlebitis AE
A surgery that is a procedure to remove the lens of your eye and, in most cases, replace it with an artificial lens. Cataract surgery is used to treat a cataract
YH, SS
cataract surgery
10063797
cataract operation
an adverse event that results in the patient developing a scab at the site of drug injection
SZ, DJ, SS, YH
10066210
injection-site scab AE
a pain AE that results in pain at the site of instillation
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/instillation
10022459
instillation site pain AE
a tremor AE that results in the patient undergoing a broad, coarse, low frequency muscle tremor
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23094990
10022520
intention tremor AE
HPO: HP_0002345
SIDER: C0234376
an adverse drug event that results in the intentional use of a drug in the wrong way (recreationally etc)
SZ, DJ, SS, YH
10065679
intentional drug misuse AE
an incorrect dose administration AE that results in overdosing on the drug on purpose
SZ, DJ, SS, YH
10022523
intentional overdose AE
a lung disorder AE that has an outcome of a disease affecting the interstitium, the tissue and space around the air sacs of the lungs
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23289473
10022611
interstitial lung disease AE
HPO: HP_0006530
SIDER: C0206062
a bone disorder AE that has an outcome of the protrusion of the nucleus pulposus or anulus fibrosus of the intervertebral disk, which may impinge on nerve roots
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/herniation+of+intervertebral+disk
10050296
intervertebral disc protrusion AE
an ischaemia AE that has an outcome of blocked or narrowed blood vessels to the small or large intestines, can cause pain and permanent damage to the intestines
SZ, DJ, SS, YH
intestinal ischaemia AE
10022680
intestinal ischemia AE
a gastrointestinal disorder AE that has an outcome of a blockage that keeps substance from passing through the intestine, may be caused by fibrous bands of tissue in the abdomen, inflamed/infected pouches in the intestine, or hernias and tumors
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001306/
10022687
intestinal obstruction AE
HPO: HP_0005250
SIDER: C0021843
a gastrointestinal disorder AE that has an outcome of perforation, or complete penetration, of the wall of the intestines
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001282/
10022694
intestinal perforation AE
a thrombosis AE that has an outcome of thrombi in the ventricles
SZ, DJ, SS, YH
WEB: http://www.cvimaging.northwestern.edu/for-physicians/cardiovascular-mri/indications/intracardiac-thrombus/
10048620
intracardiac thrombus AE
a nervous system AE that has an outcome of a rise in the pressure inside the skull that can result from or cause brain injury
SZ, DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000793.htm
10022773
intracranial pressure increased AE
HPO: HP_0002516
SIDER: C0151740
a neurological, special senses and psychiatric investigation result abnormal AE that results in an abnormal intraocular pressure in the eye
SZ, DJ, SS, YH, EB
10060951
intraocular pressure test result abnormal AE
a gastrointestinal disorder AE that results in part of the intestine invaginating itself into another part of the intestine
SZ, DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000958.htm
10022863
According to the Vaccine Adverse Event Reporting System (VAERS), 'intussusception'; is an adverse event that was mentioned in 143 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543).
intussusception AE
HPO: HP_0002576
MP: MP_0003294
SIDER: C0021933
an anemia AE that has an outcome of fewer healthy red blood cells because the body does not have enough iron
SZ, DJ, SS, YH
iron deficiency anaemia AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000584.htm
10022972
iron deficiency anemia AE
HPO: HP_0001891
SIDER: C0162316
Behavior and Neurological AE that results in the patient being easily annoyed/irritated
SZ, DJ, SS, YH
feverish (subjective) AE
10022998
irritability AE
CTCAE: E11144
HPO: HP_0000737
NCIt: C50623
SIDER: C0022107
a jaundice AE that results in an abnormal bile flow in the liver
SZ, DJ, SS, YH
cholestasis jaundice AE
WEB: http://medical-dictionary.thefreedictionary.com/cholestatic+jaundice
10023129
jaundice cholestatic AE
HPO: HP_0006575
SIDER: C0022354
a bone disorder AE that has an outcome of disease in the set of bones that hold the teeth
SZ, DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/jawinjuriesanddisorders.html
10061257
jaw disorder AE
a bone disorder AE that has an outcome of break in the jaw bone
SZ, DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000019.htm
10023149
jaw fracture AE
a thrombosis AE with an outcome of formation of a blood clot located in the internal jugular vein
SZ, DJ, SS, YH
10023237
jugular vein thrombosis AE
a bacterial infection AE with an outcome of invasion by Klebsiella pneumonia, a form of bacterial pneumonia
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/17307769
10061259
klebsiella infection AE
HPO: HP_0002742
SIDER: C0022729
a bone disorder a that results in the knee becoming deformed
SZ, DJ, SS, YH
10062061
knee deformity AE
a speech disorder AE that results in the inability of a patient to speak properly
SZ, DJ, SS, YH
10023615
lack of spontaneous speech AE
a congetical abnormality AE that results in the patient's baby being larger than it should be at the time in their pregnancy
SZ, DJ, SS, YH
10023789
large for dates baby AE
an immune system disorder AE that has an outcome of an increase in the number or proportion of natural killer cells, or cytotoxic lymphocytes critical to the innate immune system
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/10761014
10023791
large granular lymphocytosis AE
a gastrointestinal disorder AE that has an outcome of an ulcer in the large intestine
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Intestinal+ulcer
10023799
large intestinal ulcer AE
a digestive system AE that has an outcome of perforation, or complete penetration, of the walls of the large intestine
SZ, DJ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000235.htm
10023804
large intestine perforation AE
HPO: HP_0002250
SIDER: NA
an immunology and allergy investigation result abnormal that results in LE cells (neutrophil or macrophage that has phagocytized the denatured nuclear material of another cell) being detected
SZ, DJ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/LE+cell
10024062
le cells present AE
a dilatation atrial AE that results in the left atrium of the heart becoming enlarged
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096293/
10067286
left atrial dilatation AE
a cardiac ventricular disorder AE that has an outcome of inability of the left ventricle to pump blood, may lead to heart failure
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766527/
10049694
left ventricular dysfunction AE
CTCAE: E10130
NCIt: C64251
a left ventricular dysfunction AE that has an outcome of congestive heart failure marked by pulmonary congestion and edema, the left ventricle fals to contract forcefully enough to maintain normal cardiac output and peripheral perfusion
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/left+ventricular+failure
10024119
left ventricular failure AE
HPO: HP_0001635
SIDER: C0023212
a left ventricular dysfunction disorder AE that has an outcome of the thickening of the myocardium of the left ventricle of the heart
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/18030317
10049773
left ventricular hypertrophy AE
a hematopoietic system AE that has an outcome of cancer of the white blood cells characterized by return of symptoms after remission
SZ, DJ, SS, YH
leukaemia recurrent AE
WEB: http://www.yourcancertoday.com/Cancers/Leukemia-Acute-Myeloid-Adult/53
10062489
leukemia recurrent AE
a nervous system AE that has an outcome of cancerous white blood cells infiltrating the brain
SZ, DJ, SS, YH
leukaemic infiltration brain AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/1454121
10064987
leukemic infiltration brain AE
Immune system disorder AE that results in an increase in white blood cell count as a result of stress or infection
SZ, DJ, SS, YH
leukaemoid reaction AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000575.htm
10024328
leukemoid reaction AE
HPO: HP_0001909
SIDER: C0023501
an outcome of adverse event causality evidence that has an outcome of evidence is inadequate to accept or reject an adverse event causal relation
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32.
evidence inadequate to accept or reject an adverse event causal relation
an vasculitis AE that has an outcome of fragmented cells, and debris in the blood vessels. May develop skin lesions, accompanied by arthralgia and fever
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/leukocytoclastic+vasculitis
白细胞破碎性血管炎
10024377
leukocytoclastic vasculitis AE
HPO: HP_0011944
SIDER: C2973529
Urinary system AE that results in white blood cells in the urine
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/leukocyturia
10050791
leukocyturia AE
an encephalopathy AE that has an outcome of brain white matter disease
SZ, DJ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/leukoencephalopathy
10024382
leukoencephalopathy AE
CTCAE:E12712
HPO: HP_0002352
NCIt:C27059
SIDER: C0270612
a hematopoietic system AE that has an outcome of a lower than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154209/
10024384
leukopenia AE
HPO: HP_0001882
SIDER: C0023530
a psychiatric disorder AE that results in a disorder in the patient's desire for sexual interaction
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695750/
10061221
libido disorder AE
a skin AE that has an outcome of an itchy rash on the skin or in the mouth
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001870/
10024429
lichen planus AE
a skin erosion AE that results in the deterioration of the lip skin
SZ, DJ, SS, YH
10051992
lip erosion AE
a digestive system AE that has an outcome of an excess of lipase, a pancreatic enzyme, may indicate a problem related to pancreas
SZ, DJ, SS, YH
hyperlipasemia AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/15653991
10024574
lipase increased AE
CTCAE: E12185
NCIt: C78435
A medical intervention that is a tube going into a vein in your chest. It will help carry nutrients and medicine into your body. It will also be used to take blood when you need to have blood tests.
YH, SS
WEB: http://www.nlm.nih.gov/medlineplus/ency/patientinstructions/000157.htm
10053377
central venous catheterisation
Liver/biliary system AE that results in the disease of the liver
SZ, DJ, SS, YH
liver disorder
WEB: http://www.nlm.nih.gov/medlineplus/liverdiseases.html
10024670
liver AE
HPO: HP_0006706
SIDER: C0023895
a localized edema AE that shows the outcome of swelling.
SZ, DJ, SS, YH
10024770
local swelling AE
an infection AE located in a certain area
SZ, DJ, SS, YH
localised infection AE
10024774
localized infection AE
HPO: HP_0002719
SIDER: C0016397
Abnormal fluid regulation AE that results in a collection of fluid in the intraabdominal area
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/intra-abdominal
10066768
localised intraabdominal fluid collection AE
an edema AE occuring in a specific region
SZ, DJ, SS, YH
localised edema AE
localised oedema AE
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115975/
10048961
10062466
localized edema AE
CTCAE: E11148
HPO: HP_0000969
NCIt: C78437
SIDER: C0013609
a movement disorder AE that has an outcome of loss of the sense of the relative position of neighbouring parts of the body and strength of effort being employed in movement
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/8294975
10057332
loss of proprioception AE
a gastrointestinal hemorrhage AE that has an outcome of bleeding in the lower gastrointestinal tract
SZ, DJ, SS, YH
lower gastrointestinal haemorrhage AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003133.htm
10050953
lower gastrointestinal hemorrhage AE
HPO: HP_0002239
SIDER: C0024050
an infection AE that has an outcome of infection in the lower respiratory tract, includes pneumonea as well as lung abscess and acute bronchitis
SZ, DJ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/books/NBK8142/
10024968
lower respiratory tract infection AE
HPO: HP_0002783
SIDER: C0149725
a lung disorder AE that has an outcome of liquid filling a region of lung tissue, marked by induration of a normally aerated lung
SZ, DJ, SS, YH
pulmonary consolidation AE
WEB: http://medical-dictionary.thefreedictionary.com/consolidation
10025080
lung consolidation AE
an infection AE that has an outcome of infection in the lungs
SZ, DJ, SS, YH
WEB: http://www.livestrong.com/lung-infection/
10061229
lung infection AE
CTCAE: E11444
HPO: HP_0002783
NCIt: C26873
SIDER: C0876973
a lung disorder AE that has an outcome of an abnormal presence of granulomas, fluid, inflammatory exudates or cells in the lung tissue
SZ, DJ, SS, YH
WEB: http://www.blurtit.com/q840550.html
10025102
lung infiltration AE
HPO: HP_0005828
SIDER: C0235896
a tumor AE that has an outcome of a malignant tumor in the lung
SZ, DJ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Lung+neoplasm
10062042
lung neoplasm AE
HPO: HP_0100526
SIDER: C0024121
an immune system disorder AE that has an outcome of lymphadenopathy, which is a term meaning "disease of the lymph nodes" . It is generally a disease or inflammation of the lymph nodes, could be due to infection, auto-immune disease or malignancy
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/lymphadenopathy
10025197
lymphadenopathy AE
HPO: HP_0002716
SIDER: C0497156
an inflammation AE occuring in the lymph vessels secondary to a malignancy
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/8930034
10053132
lymphangiosis carcinomatosa AE
a lymphocyte count abnormal AE that has an outcome of a decreased amount of lymphocytes in the blood, a type of white blood cell in the immune system
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm
10025256
lymphocyte count decreased AE
CTCAE: E12190
NCIt: C26823
a lymphocyte percentage abnormal AE that results in an increase in the levels of lymphocytes in the blood
SZ, SS, YH, EB
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003657.htm
10052232
lymphocyte percentage increased AE
an immune system disorder AE that results in lymphocytes being infiltrated by harmful substances
SZ, SS, YH
WEB: http://emedicine.medscape.com/article/1098654-overview
10062049
lymphocytic infiltration AE
an immune system disorder AE that has an outcome of an increase in the number or proportion of lymphocytes in the blood
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/lymphocytosis
10025280
lymphocytosis AE
HPO: HP_0012141
SIDER: C0024282
an edema AE that has an outcome of localized fluid retention and tissue swelling caused by a compromised lymphatic system
SZ, SS, YH
WEB: Primary Source: http://emedicine.medscape.com/article/1087313-overview Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23073712
10025282
lymphoedema AE
HPO: HP_0001004
SIDER: C0024236
a hematopoietic system AE that has an outcome of reduction in the number of lymphocytes in the blood
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/lymphopenia
10025327
lymphopenia AE
HPO: HP_0001888
SIDER: C0024312
a eye disorder AE that has an outcome of cell death in the macula of the eye, destroying central vision
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/maculardegeneration.html
10025409
macular degeneration AE
HPO: HP_0007673
SIDER: C0024437
a male reproductive system disorder AE that results in the inability of the male to achieve an orgasm despite lengthy sexual contact
SZ, SS, YH
WEB: http://www.minddisorders.com/Kau-Nu/Male-orgasmic-disorder.html#b
10025513
male orgasmic disorder AE
a tumor AE that has an outcome of growth or proliferation of an abnormal mass of tissue
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/19824467
10061309
malignant neoplasm progression AE
an respiratory system AE that has an outcome of abnormal amount of fluid collecting between the layers of tissue lining the outside of the lung and wall of chest cavity, caused by cancer
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/11529302
10026673
malignant pleural effusion AE
A surgery that is a surgical procedure to remove all or part of your colon.
YH, SS
WEB: http://www.mayoclinic.com/health/colectomy/MY00141/METHOD=print
10061778
colectomy
a surgery that is performed to change the size of breasts
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/mammoplasty
10068647
mammoplasty
an arterial disorder AE that resuts in arteries that supply blood to heart muscle become hardened and narrowed.
YH, SS
coronary artery disese AE
WEB: http://www.nlm.nih.gov/medlineplus/coronaryarterydisease.html
10011078
10011082
coronary artery disorder AE
a hematopoietic system AE that has an outcome of bone marrow that contains an excess of blood cells
SZ, SS, YH
WEB: http://www.mayoclinic.com/health/aplastic-anemia/DS00322/DSECTION=causes
10026851
marrow hyperplasia AE
a perinatal AE that results in the drugs being taken by the mother affecting unborn fetus in mother
SZ, SS, YH
maternal drugs affecting foetus AE
10026923
maternal drugs affecting fetus AE
an adverse event that results in a problem in the mediastinum of the patient (undelineated group of structures in the thorax surrounded by loose connective tissue)
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Mediastinal+diseases
10061280
mediastinal disorder AE
HPO: HP_0000765
SIDER: C0025061
a digestive system AE that has an outcome of abnormal dilation of the colon, often accompanied by paralysis of the peristaltic movements of the bowel
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/megacolon
10027110
megacolon AE
HPO: HP_0002251
SIDER: C0025160
Abnormal defecation AE that results in black feces associated with gastrointestinal hemorrhage
SZ, SS, YH
melaena AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003130.htm
10027141
melena AE
HPO: HP_0002249
SIDER: C0025222
Behavior and Neurological AE that results in the loss of memory
SZ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/impaired+memory
10027175
memory impairment AE
CTCAE:E12718
HPO: HP_0002354
NCIt:C78444
SIDER: C0233794
a brain inflammation AE that results in the layers lining the brain becoming inflamed, not due to pygonenic bacteria
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/aseptic+meningitis
10027201
meningitis aseptic AE
HPO: HP_0001287
SIDER: C0025290
Hematuria AE that results in excessive uterine bleeding occurs irregularly and more frequently than normal
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/menometrorrhagia
10027295
menometrorrhagia AE
HPO: HP_0100608
SIDER: C0232943
Female Reproductive System AE that results in abnormally heavy and prolonged menstrual period
SZ, SS, YH, MW
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0014910/
10027313
menorrhagia AE
CTCAE:E13132
HPO: HP_0000132
NCIt:C26829
SIDER: C0025323
a psychiatric disorder AE that has an outcome of changes in mental status
SZ, SS, YH, Izabela Birsanescu
WEB: http://www.medicinenet.com/altered_mental_status/symptoms.htm
10048294
A mental status change does not have to be a disorder or even an adverse event. It can be a good change, from a disorder status to a normal recovered status.
mental status changes AE
a metabolism, endocrine, and exocrine system AE that has an outcome of abnormal chemical reactions in the body that disrupts a metabolic process
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/metabolicdisorders.html
10058097
metabolic disorder AE
A cardiac disorder AE that has an outcome of enlargement of the heart
YH, SS
atrial dilatation, atrial enlargement
10013002
dilatation atrial AE
an abdominal AE that shows the spreading of the cancer cells to the abdominal cavity of the patient
SZ, SS, YH
WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/002260.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/19373966
10027450
metastasis to abdominal cavity AE
a tumor AE that has an outcome of cancerous cells spreading to the bone from elsewhere
SZ, SS, YH
10027452
metastasis to bone AE
a tumor AE that results in cancerous cells spreading from a primary tumor to the central nervous system
SZ, SS, YH
WEB: http://theoncologist.alphamedpress.org/content/8/5/398.long, http://www.ncbi.nlm.nih.gov/pubmed/19373966
10059282
metastasis to central nervous system AE
a tumor AE that results in cancerous cells spreading to the liver organ
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000277.htm
10027457
metastasis to liver AE
a tumor AE that results in cancerous cells spreading to the lung
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000097.htm
10027458
metastasis to lung AE
a tumor AE that has an outcome cancerous cells spreaing from primary tumor to the thin layers of tissue that protect the brain and spinal cord, may experience increased intracranial pressure
SZ, SS, YH
meningeal metastasis AE
WEB: 1. http://theoncologist.alphamedpress.org/content/1/1/56.full 2. http://www.cancer.gov/dictionary?cdrid=45782
10051696
metastasis to meninges AE
a tumor AE that results in cancerous cells spreading from primary tumor to the lining of the abdominal cavity or the coelom.
SZ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/peritoneum Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed?term=metastasis%20to%20peritoneum%20%5BTI%5D
10051676
metastasis to peritoneum AE
a tumor AE that results in a disease spreading to the pleural cavity due to cancerous activities
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/pleuraldisorders.html
10027463
metastasis to pleura AE
an outcome of adverse event causality evidence that has an outcome of evidence favors rejection of an adverse event causal relation
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32.
evidence favoring rejection of an adverse event causal relation
a tumor AE that results in cancerous cells spreading to the spine
SZ, SS, YH
WEB: http://emedicine.medscape.com/article/1157987-overview
10027468
metastasis to spine AE
a tumor AE with an outcome of spreading of disease from one organ to another non-adjacent organ or part
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002260.htm
10062194
metastasis AE
a tumor AE with an outcome of spreading of cancerous cells from abnormal mass of tissue
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/20121607
10061289
metastatic neoplasm AE
Urinary System AE that is characterized by uterine bleeding at irregular intervals
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/metrorrhagia
10027514
metrorrhagia AE
HPO: HP_0100608
SIDER: C0025874
Cardiovascular disorder AE that results in a fragmentation of red blood cells resulting from the narrowing of small blood vessels
SZ, SS, YH
microangiopathic haemolytic anaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/microangiopathic+hemolytic+anemia
10027527
microangiopathic hemolytic anemia AE
HPO: HP_0001937
SIDER: C0221021
a cardiac valve disease AE that is characterized by the inability of the heart's mitral valve to close tightly, allowing blood to flow backward in the heart
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Mitral+Valve+Insufficiency
10027727
mitral valve incompetence AE
HPO: HP_0001653
SIDER: C0026266
a digestive system AE that has an outcome of bleeding from blood vessels located in the mouth
SZ, SS, YH
mouth haemorrhage AE
WEB: http://sideeffects.embl.de/se/C0029163/
10028024
mouth hemorrhage AE
HPO: HP_0000167
SIDER: C0029163
a digestive system AE that has an outcome of sores or open lesions in the mouth
SZ, SS, YH
aphthous stomatitis AE
canker sore AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001448.htm
10028034
mouth ulceration AE
HPO: HP_0000155
SIDER: C0149745
Multiple Sclerosis AE that is characterized by a relapse of Multiple Sclerosis
SZ, SS, YH
WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001747/ Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22980532
10048393
multiple sclerosis relapse AE
a muscle contraction AE that has an outcome of painful sensations, associated with muscle fatigue and low sodium/potassium
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/musclecramps.html
10028294
muscle cramp AE
a muscle enzyme level abnormal AE that results in an increased level of muscle enzyme
SZ, SS, YH
10057945
muscle enzyme level increased AE
a muscle AE that results in the musculoskeletal system being weakened at locomotion is hampered
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002172/
10028356
muscular dystrophy AE
a pain AE located in musculoskeletal structures of the chest wall, atypical or noncardiac chest pain
SZ, SS, YH
WEB: http://www.uptodate.com/contents/major-causes-of-musculoskeletal-chest-pain?source=see_link
10050819
musculoskeletal chest pain AE
HPO: HP_0006649
SIDER: C0476280
Bacterial infection AE that results in the patient being infected with the Mycoplasma bacteria
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/15142464
10061300
mycoplasma infection AE
an outcome of adverse event causality evidence that has an outcome of evidence favors acceptance of an adverse event causal relation
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 32.
evidence favoring acceptance of an adverse event causal relation
a hematopoietic system AE that has an outcome of ineffective production of the myeloid class of blood cells
SZ, SS, YH, MW
WEB: http://www.nlm.nih.gov/medlineplus/myelodysplasticsyndromes.html
10028533
myelodysplastic syndrome AE
CTCAE:E12552
HPO: HP_0006730
NCIt:C3247
SIDER: C0026986
a hematopoietic system AE that has an outcome of bone marrow being replaced by scar tissue
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001558/
10028537
myelofibrosis AE
HPO: HP_0011974
SIDER: C0026987
a cardiac disorder AE that has an outcome of an imbalance between myocardial oxygen supply and demand
SZ, SS, YH
myocardial ischaemia AE
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1768241/
10028600
myocardial ischemia AE
HPO: HP_0001637
SIDER: C0151744
an inflammation AE that has an outcome of inflammation of the heart muscle
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001204/
10028606
myocarditis AE
CTCAE: E10157
NCIt: C34831
a bone disorder AE, most commonly fungal infection, that is characterized by discoloration, painful swelling, pits, lesions and brown bands
SZ, SS, YH
WEB: http://www.umm.edu/altmed/articles/nail-disorders-000116.htm
10028694
nail disorder AE
HPO: HP_0001597
SIDER: C0027339
a nail AE around the nail area, tends to be fungal
SZ, SS, YH
WEB: http://www.emedicinehealth.com/paronychia_nail_infection/article_em.htm
10061304
nail infection AE
HPO: HP_0008396
SIDER: C0343026
Cell death AE that results in necrosis occurring due to a local deprivation of blood
SZ, SS, YH
necrosis ischaemic AE
WEB: http://medical-dictionary.thefreedictionary.com/ischemic+necrosis
10028862
necrosis ischemic AE
a progressive tumor AE that has an outcome of an abnormal mass of cells that metastasizes
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/malignant+neoplasm
10028997
neoplasm malignant AE
HPO: HP_0002664
SIDER: C0006826
an tumor AE that has an outcome of growth of the neoplasm, an abnormal mass of tissue in the body
SZ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/neoplasm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23263846
10061309
neoplasm progression AE
a tumor AE that has an outcome of microscopic cells of the original neoplasm escaping therapeutic intervention and later becoming clinically visible at the original site
SZ, SS, YH
10061864
neoplasm recurrence AE
Kidney disorder AE that results in an increased amount of calcium deposits in the renal parenchyma
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001522/
10029146
nephrocalcinosis AE
HPO: HP_0000121
SIDER: C0027709
a kidney disorder AE that has an outcome of a group of symptoms that include protein in the urine, low blood protein levels, high cholesterol levels, high triglyceride levels and swelling
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001520/
10029164
nephrotic syndrome AE
HPO: HP_0000100
SIDER: C0027726
a neuropathy AE that has an outcome of direct pressure on a single nerve, can cause pain, tingling and muscle weakness
SZ, SS, YH
WEB: http://nerve.wustl.edu/nd_compression.php
10029174
nerve compression AE
Nervous System AE that results in pressure on a root nerve
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/6719259
10061866
nerve root compression AE
Nervous system AE that results in a lesion occurring on a nerve root
SZ, SS, YH
10029188
nerve root lesion AE
A nervous system AE that has an outcome of inability of maintaining neurological functions.
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/decompensation
10068357
neurological decompensation AE
Tumor AE that results in a tumor growing on nerve tissue
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/neuroma
10029308
neuroma AE
HPO: HP_0009588
SIDER: C0027858
a nervous system AE that alters the normal activity of the nervous system due to exposure to neurotoxins (which can be natural or artificial toxic substances), and causes damage to nervous tissue
SZ, SS, YH, QL
toxic neuropathy AE
WEB: http://en.wikipedia.org/wiki/Neurotoxicity
10029350
10067722
neurotoxicity AE
an immunolgy and allergy investigation result abnormal AE that is chracterized by neutralising antibodies detected in the blood
SZ, SS, YH, EB
neutralising antibodies positive AE
WEB: http://medical-dictionary.thefreedictionary.com/neutralizing+antibody
10064980
neutralizing antibodies positive AE
a neutropenia AE that compromises the immune system where the number of neutrophil granulocytes, a type of white blood cell, is abnormally low. A neutropenia makes body vulnerable to bacterial and fungal infections.
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/neutropenia
10029354
neutropenia AE
HPO: HP_0001875
SIDER: C0027947
a neutropenia AE that results in an abnormal number of neutrophils in a newborn infant
SZ, SS, YH
WEB: http://www.thefreedictionary.com/neonatal, http://medical-dictionary.thefreedictionary.com/neonatal+neutropenia,+alloimmune
10029358
neutropenia neonatal AE
a gastrointestinal Inflammation AE that results in the cecum, part of the large intestine, being inflamed
SZ, SS, YH
WEB: http://emedicine.medscape.com/article/183791-overview
10062959
neutropenic colitis AE
HPO: HP_0002583
SIDER: C0400823
a sepsis AE caused by neutropenia or an abnormally low neutrophil count
SZ, SS, YH
WEB: http://guidance.nice.org.uk/CG151
10049151
neutropenic sepsis AE
a white blood cell profile abnormal AE that results in an abnormal number of neutrophil granulocytes, a type of white blood cell (outside the normal range of ~1700 per microliter)
SZ, SS, YH, EB
WEB: http://www.medterms.com/script/main/art.asp?articlekey=20030
10061313
neutrophil count abnormal AE
a neutrophil count abnormal AE that has an outcome of decreased neutrophil count
SZ, SS, YH, EB
neutropenia AE
WEB: http://www.mayoclinic.com/health/neutropenia/MY00110
10029366
neutrophil count decreased AE
CTCAE: E12198
HPO: HP_0011991
NCIt: C80520
SIDER: NA
a neutrophil percentage abnormal AE that has an outcome of increase in percentage of neutrophils, a type of white blood cell
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/neutrophil
10052224
neutrophil percentage increased AE
a hyperplasia AE that has an outcome of liver/biliary system cell overproduction, associated with portal hypertension
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070012/
10051081
nodular regenerative hyperplasia AE
a lung disorder AE that has an outcome of adenocarcinomas in an outer area of the lung, squamous cell carcinomas in the center of the lung or large cell carcinomas in any part of the lung
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004462/
10061873
non-small cell lung cancer AE
a lung disorder AE that results in the patient suffering from lung cancer at state IV
SZ, SS, YH
10029522
non-small cell lung cancer stage iv AE
an anemia AE that has an outcome of insufficient numbers of red blood cells despite a normal concentration of hemoglobin in the cells
SZ, SS, YH
normochromic normocytic anaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/normocytic+normochromic+anemia
10029783
normochromic normocytic anemia AE
HPO: HP_0001897
SIDER: C0271899
a surgery that aims to control obesity
SZ, SS, YH
10059610
obesity surgery
a respiratory system AE that has an outcome of chronic bronchitis or emphysema which causes the airways to narrow over time
SZ, SS, YH
WEB: http://www.medicinenet.com/chronic_obstructive_pulmonary_disease_copd/article.htm
10061877
obstructive airways disorder AE
HPO: HP_0006536
SIDER: C0600260
a gastrointestinal investigation result abnormal AE that results in blood that is present in amounts too small to be seen and can be detected only by chemical analysis or microscopic examination
SZ, SS, YH, EB
WEB: http://dictionary.reference.com/browse/occult+blood
WEB: http://medical-dictionary.thefreedictionary.com/occult+blood\
10061878
occult blood AE
a gustatory system AE that has an outcome of painful swallowing in the mouth or esophagus. Can lead to weight loss.
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/odynophagia
10030094
odynophagia AE
a pain AE located in the esophagus
SZ, SS, YH
oesophageal pain AE
WEB: http://medical-dictionary.thefreedictionary.com/oesophageal
10015388
10030180
esophageal pain AE
CTCAE: E10661
HPO: HP_0010833
NCIt: C78280
SIDER: C0221727
an esophagus AE that results in a narrowing in the esophagus caused by buildup of scar tissue or by a congenital defect
SZ, SS, YH
oesophageal stenosis AE
WEB: http://esophagealstenosis.org/
10015448
10030194
esophageal stenosis AE
CTCAE: E10670
HPO: HP_0010450
NCIt: C34595
SIDER: C0014866
an esophagus AE located in the esophagus, can present with heartburn, and nausea
SZ, SS, YH
oesophagitis AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002138/
10015461
10030216
esophagitis AE
CTCAE: E10687
HPO: HP_0100633
NCIt: C9224
SIDER: C0014868
a reproductive system AE that has an outcome of insufficient placenta, the baby may get less oxygen and nutrients
SZ, SS, YH
placental dysfunction AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002455/
10030289
oligohydramnios AE
HPO: HP_0001562
SIDER: C0079924
a nail disorder AE that has an outcome of pain in the fingernails or toenails
SZ, SS, YH
WEB: http://dictionary.reference.com/browse/onychalgia
10064251
onychalgia AE
a nail disorder AE that results in the breaking of the fingernails or toenails
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/onychoclasis
10048886
onychoclasis AE
HPO: HP_0001808
SIDER: C0546956
a nail disorder AE that results in the nail separating from the nail bed starting at distal or lateral attachment
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/16422468
10030337
onycholysis AE
HPO: HP_0008400
SIDER: C0085661
an outcome of adverse event causality evidence that has an outcome of evidence establishes an adverse event causal relation
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 33.
evidence establishing an adverse event causal relation
a nail disorder AE that results in nails spontaneously shedding starting from the proximal end
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/onychomadesis
10049274
onychomadesis AE
Eye disorder AE that results in chronic glaucoma progressing slowly
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002587/
10030348
open angle glaucoma AE
HPO: HP_0000501
SIDER: C0017612
a toxicology drug screen result abnormal AE that results in the patient testing positive for opiates
SZ, SS, YH, EB
10063232
opiates positive AE
a digestive system AE that has an outcome of a fungal infection located in the mouth caused by the candida fungus
SZ, SS, YH
thrush AE
WEB: http://www.medicinenet.com/thrush/article.htm
10030963
oral candidiasis AE
HPO: HP_0009098
SIDER: C0006849
a digestive system AE that has an outcome of fistula, or an abnormal connection between two epithelium-lined organs or vessels, located in the oral cavity
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/fistula
10065720
oral cavity fistula AE
CTCAE: E10888
NCIt: C78506
a digestive system AE that has an outcome of a viral infection located in the mouth caused by herpes simplex virus, causes painful sores
SZ, SS, YH
WEB: http://www.emedicinehealth.com/oral_herpes/article_em.htm
10067152
oral herpes AE
a gustatory system AE that has an outcome of a decreased amount of substance in food or drinking water ingested
SZ, SS, YH
oral intake reduced AE
Digestive System AE that results in oral lesions
SZ, SS, YH
10064594
oral mucosa erosion AE
an erythema AE that results in redness of the oral mucosa area
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/17767983
10067418
oral mucosal erythema AE
a pain AE located in the oral cavity, pertaining to the mouth
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/oral
10031009
oral pain AE
HPO: HP_0010833
SIDER: C0221776
a digestive system AE that has an outcome of disease in the soft tissue of the mouth or systemic diseases involving the mouth
SZ, SS, YH
WEB: http://clinicaltrials.gov/show/NCT00001601
10031015
oral soft tissue disorder AE
a surgery that treats injuries and defects involving both the functional and esthetic aspects of the hard/soft tissue of the head, mouth, teeth, gums, jaws, and neck
SZ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/oral+surgery Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22530364
10051059
oral surgery
an edema that results in swelling around the eyes
SZ, SS, YH
orbital oedema AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/7654583
10031051
orbital edema AE
HPO: HP_0100539
SIDER: C0424813
a pneumonia AE that results in the healing process being characterized by organization and cicatrizaion of the exudate rather than resolution
SZ, SS, YH
organising pneumonia AE
WEB: Primary Source: http://thorax.bmj.com/content/55/4/318.full Secondary Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745738/
10067472
organizing pneumonia AE
HPO: HP_0002090
SIDER: C0264383
Digestive System AE that is characterized by fungus (mainly Candida albicans, but can be other Candida species - C.glabrata, C. tropicalis, C. krusei) in throat or mouth (Thrush)
SZ, SS, YH
WEB: http://www.cdc.gov/fungal/candidiasis/thrush/
10050346
oropharyngeal candidiasis AE
HPO: HP_0009098
SIDER: C0919659
a digestive system AE that has an outcome of muscle spasm in the oropharynx area
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Oropharyngeal+airway
10031111
oropharyngeal spasm AE
HPO: HP_0003739
SIDER: C0234952
a bone disorder AE that has an outcome of bacterial infection in the bone
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001473/
10031252
osteomyelitis AE
HPO: HP_0007626
SIDER: C0029443
a bone disorder AE that has an outcome of chronic infection of the bone or bone marrow
SZ, SS, YH
WEB: Primary Source: http://www.posna.org/education/StudyGuide/chronicOsteomyelitis.asp Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/20471296
10031256
osteomyelitis chronic AE
a data item that represents the ratio of the rate of occurence of the adverse event in persons having the medical intervention (e.g., vaccination) to the rate in otherwise comparable persons without the medical intervention.
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20-21.
adverse event relative risk
a bone disorder AE that has an outcome of bone death due to the loss of blood supply, leading to pain and arthritis
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/osteonecrosis.html
10031264
osteonecrosis AE
HPO: HP_0010885
SIDER: C0029445
a bone disorder AE that has an outcome of disease that affects the maxilla and the mandible, characterized through exposure of the bone through lesions in the gingiva that do not heal
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/16702591
10064658
osteonecrosis of jaw AE
HPO: HP_0010885
SIDER: C1401381
a bone disorder AE that has an outcome of necrosis or death of bone as a result of exposure to radiation
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/osteoradionecrosis
10067352
osteoradionecrosis AE
a bone disorder AE that has an outcome of elevation in bone density
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/osteosclerosis
10031298
osteosclerosis AE
HPO: HP_0011001
SIDER: C0029464
a female reproductive system AE that has an outcome of cancer that starts in the ovaries, female reproductive organs that produce eggs
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001891/
10033128
ovarian cancer AE
HPO: HP_0100615
SIDER: C1140680
Female reproductive system AE that results in an enlargement of the patient's ovaries
SZ, SS, YH
10033157
ovarian enlargement AE
a female reproductive system AE that has an outcome of an abnormal mass appearing in the patient's ovaries
SZ, SS, YH
10058823
ovarian mass AE
Incorrect dose administration AE that results in the ingestion or application of a drug in greater quantities than recommended
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007287.htm
10033295
overdose AE
an oxygen saturation abnormal AE that has an outcome of a decreased percentage of hemoglobin binding sites in the bloodstream occupied by oxygen
SZ, SS, YH, EB
WEB: Primary Source: http://www.mayoclinic.com/health/hypoxemia/MY00219\ Secondary Source: http://medical-dictionary.thefreedictionary.com/oxygen+saturation
10033318
oxygen saturation decreased AE
a pain AE that has an outcome of pain in the set of bones that hold the teeth
SZ, SS, YH
10033433
pain in jaw AE
HPO: HP_0200023
SIDER: C0236000
a pain AE located in the skin
SZ, SS, YH, MW
10033474
pain of skin AE
CTCAE:E13668
HPO: HP_0010833
NCIt:C78516
SIDER: C0241136
a erythema AE that is characterized by the reddening of the palms at the thenar and hypothenar eminences
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/18039017
10033551
palmar erythema AE
HPO: HP_0007548
SIDER: C0014745
a skin AE generally caused by chemotherapy that is characterized by the palms and soles becoming red, swollen, numb and the skin peeling.
YH: MedDRA: 10033553 is for "palmar-plantar erythrodysaesthesia syndrome"; MedDRA: 10054524 is for "palmar-plantar erythrodysesthesia syndrome".
SZ, SS, YH, MW
Hand Food Syndrome AE
palmar-plantar erythrodysaesthesia syndrome AE
WEB: http://news.cancerconnect.com/hand-foot-syndrome-palmar-plantar-erythrodysesthesia/
palmar-plantar erythrodysesthesia syndrome AE
CTCAE: E13672
NCIt: C27177
UMLS CUI: C0549410
Tumor AE that results in an undifferentiated growth in the patient's pancreas
SZ, SS, YH
WEB: Primary Source: http://stanfordhospital.org/digestivehealth/pancreas/conditions/pancreatic-cysts-symptoms-diagnosis.html Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22855657
10049082
pancreatic mass AE
a pancreatitis AE that has an outcome of sudden inflammation of the pancreas
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000287.htm
10033647
pancreatitis acute AE
HPO: HP_0001735
SIDER: C0001339
a pancreatitis AE that results in pancreatitis reoccurring in the patient
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002129/
10033657
pancreatitis relapsing AE
Hematopoietic System AE that results in a reduction in the amount of red and white blood cells and platelets in blood
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/pancytopenia
10033661
pancytopenia AE
HPO: HP_0001876
SIDER: C0030312
an edema AE that has an outcome of optic disc swelling that is caused by increased intracranial pressure
SZ, SS, YH
papilledema AE
WEB: http://medical-dictionary.thefreedictionary.com/Papilloedema
10033703
10033712
papilloedema AE
CTCAE: E10411
HPO: HP_0001085
NCIt: C3307
SIDER: C0030353
a data item that represents the incidence of the adverse event among recipients of a medical intervention (e.g., vaccinatoin) minus the incidence of the adverse event among otherwise similar nonrecipients.
The AE risk difference depends on both the background incidence of the adverse event (i.e., among nonrecipients) and the relative risk of its occurence in medical intervention recipients versus nonrecipients. Even when the AE rlative risk is high, the AE risk difference will be low if the event is extremely rare.
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 27.
adverse event risk difference
Tumor AE that results in a benign tumor in the parathyroid region
SZ, SS, YH
parathyroid tumour benign AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001188.htm
10033964
parathyroid tumor benign AE
a skin infection AE thar occurs around the fingernails and toenailsnail. Bacteria or a type of yeast called Candida cause this infection. Bacteria and yeast can even combine into one infection.
SZ, SS, YH, MW
nail infection AE
WEB: http://www.healthline.com/health/paronychia
WEB: https://en.wikipedia.org/wiki/Paronychia
10034016
paronychia AE
HPO: HP_0001818
SIDER: C0030578
a bone disorder AE that has an outcome of a broken bone caused by disease leading to weakenss of the bone, commonly osteoporosis
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/pathological+fracture
10034156
pathological fracture AE
HPO: HP_0005744
SIDER: C0016663
a cardiac disorder AE that has an outcome of abnormal accumulation of fluid in the pericardial cavity
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110902/
10034474
pericardial effusion AE
CTCAE: E10172
HPO: HP_0001698
NCIt: C3319
SIDER: C0031039
a pain AE that results in soreness around the vaginal opening after giving birth
SZ, SS, YH, MW
WEB: http://www.ncbi.nlm.nih.gov/pubmed/20002420
10061339
perineal pain AE
CTCAE:E13175
NCIt:C78529
a digestive system AE that has an outcome of inflammation and infection that destroys the tissues that support the teeth, including the gums, the periodontal ligaments and the tooth sockets
SZ, SS, YH
gingivitis AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002051/
牙龈炎
10034536
periodontal disease AE
HPO: HP_0000704
SIDER: C0031090
a bone disorder AE that has an outcome of inflammation and infection of the ligaments and bones that support the teeth
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002054/
10034539
periodontitis AE
HPO: HP_0000704
SIDER: C0031099
an ischaemia AE that has an outcome of restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism
YH: MedDRA: 10034576 is for "peripheral ischaemia"; MedDRA: 10034578 is for "peripheral ischemia".
SZ, SS, YH
peripheral ischaemia AE
WEB: Primary Source: http://www.medterms.com/script/main/art.asp?articlekey=4052 Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/6430442
外周缺血
10034576
10034578
peripheral ischemia AE
CTCAE:E13810
HPO: HP_0002597
NCIt: C78535
SIDER: C0235490
a motor neuropathy AE that results in damage to the nerves outside of the brain and spinal cord
SZ, SS, YH, MW
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001619/
10034580
peripheral motor neuropathy AE
CTCAE:E12762
HPO: HP_0007178
NCIt:C3500
SIDER: C0235025
a peripheral sensory neuropathy AE that results in the patient losing the ability to move or feel.
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000750.htm
10056673
Neuropathy can affect nerves that provide feeling (sensory neuropathy) or cause movement (motor neuropathy). It can also affect both, in which case it is called a sensorimotor neuropathy.
peripheral sensorimotor neuropathy AE
a sensory neuropathy AE that has an outcome of damaged nerves outside the brain and spinal cord
SZ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/Peripheral+sensory+neuropathy
10034620
peripheral sensory neuropathy AE
CTCAE:E12768
HPO: HP_0000763
NCIt:C3501
SIDER: C0151313
an abscess AE that results in a collection of infected material around the tonsils
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001981/
10034686
peritonsillar abscess AE
HPO: HP_0001739
SIDER: C0031157
Respiratory system AE characterized by the whooping cough
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002528/
10034738
pertussis AE
a hemorrhage AE that has an outcome of tiny pinpoint red dots that form due to broken blood vessels under the skin
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003235.htm
10034754
petechiae AE
HPO: HP_0000967
MP: MP_0008816
SIDER: C0031256
Inflammation AE that results in an inflammation of the pharyngeal region
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/11172144
10065716
pharyngeal inflammation AE
a phlebitis that is characterized by blood clots that occur in different locations
SZ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Thrombophlebitis Secondary Source: http://emedicine.medscape.com/article/463256-overview
10034902
phlebitis superficial AE
a skin AE that results in the patient's skin becoming diseased due to exposure to sunlight
SZ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/photodermatosis Secondary Source http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063367/
10051246
photodermatosis AE
HPO: HP_0000992
SIDER: C0920193
a skin AE that shows a cutaneous disease as a result of sun allergy and may be induced by different triggers such as a chemical.
MedDRA: 10034972 and UMLS CUI: C0162830 are for "photosensitivity reaction"; MedDRA: 10034966 and UMLS CUI: C0349506 are for "photosensitivity".
SZ, SS, YH, MW
photosensitivity AE
WEB: http://emedicine.medscape.com/article/1049648-overview
WEB: http://www.merckmanuals.com/home/skin-disorders/sunlight-and-skin-damage/photosensitivity-reactions
10034966
10034972
photosensitivity reaction AE
CTCAE: E13680
HPO: HP_0000992
NCIt: C38004
SIDER: C0162830
UMLS CUI: C0349506; UMLS CUI: C0162830
a skin AE that has an outcome of loss or reduction in human skin color, may be related to loss of melanocytes or inability of melanocytes to produce melanin
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/skinpigmentationdisorders.html
10062080
pigmentation disorder AE
HPO: HP_0001000
SIDER: C0549567
a conduction system disorder AE that refers to partial or complete block of electrical impulses originating in the atrium or sinus node, preventing them from reaching the AV node and ventricles
SS
AV block
heart block
WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751
10003671
atrioventricular block AE
HPO: HP_0001678
SIDER: C0004245
a respiratory system AE that has an outcome of fluid buildup between the layers of tissue that line the lungs and chest cavity
SZ, SS, YH, MW
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001150/
10035598
pleural effusion AE
CTCAE:E13486
HPO: HP_0002202
NCIt:C3331
SIDER: C0032227
a hemorrhage AE that has an outcome of bleeding in the pleural cavity, the potential space between the two pleura of the lungs
MedDRA: 10035601 is for "pleural haemorrhage"; MedDRA: 10055319 is for "pleural hemorrhage".
SZ, SS, YH
pleural haemorrhage AE
WEB: http://medical-dictionary.thefreedictionary.com/hemothorax
10035601
10055319
pleural hemorrhage AE
CTCAE: E13492
NCIt: C50582
UMLS CUI: C0019123
a lung disorder AE that has an outcome of inflammation of the lining of the lungs and chest that leads to chest pain
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002347/
10035618
pleurisy AE
HPO: HP_0002102
SIDER: C0032231
a pain AE induced by inflammation in the lungs that is characterized by sharp or stabbing pain in the chest
SZ, SS, YH, MW
WEB: http://pleuriticchestpain.net/, http://medical-dictionary.thefreedictionary.com/Pleuritic+chest+pain
10035623
pleuritic pain AE
CTCAE:E13498
NCIt:C78564
a gastrointestinal disorder AE that results in gas cysts developing within the walls of the small or large intestine
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/9530294
10057030
pneumatosis intestinalis AE
a pneumonia AE that has an outcome of a fungal infection of the lungs by Pneumocystis jiroveci
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001692/
10064108
pneumocystis jiroveci pneumonia AE
HPO: HP_0002096
SIDER: C1535939
Respiratory System AE that results in air being present in the mediastinum
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001148/
10050184
pneumomediastinum AE
a pneumonia AE that has an outcome of inflammation in the lungs and airways to the lungs from breathing in foreign material
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000121.htm
10035669
pneumonia aspiration AE
HPO: HP_0002100
SIDER: C0032290
a pneumonia AE that has an outcome of an acute systemic disease with involvement of the lungs, caused by Mycoplasma pneumoniAE and marked by high fever and cough
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/primary+atypical+pneumonia
10035730
pneumonia primary atypical AE
a lung inflammation AE located in the lung tissue
SZ, SS, YH, MW
pulmonitis AE
WEB: http://medical-dictionary.thefreedictionary.com/pneumonitis
10035742
pneumonitis AE
CTCAE:E13502
NCIt:C3333
a lung disorder AE that has an outcome of a collapsed lung due to collection of air in the space around the lungs.
SZ, SS, YH, MW
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001151/
10035759
pneumothorax AE
CTCAE:E13508
HPO: HP_0006522
NCIt:C38006
SIDER: C0032326
a urinary system AE that results in abnormally frequent urination
SZ, SS, YH
frequent micturition AE
polyuria AE
WEB: http://www.merriam-webster.com/medical/pollakiuria
10036018
pollakiuria AE
HPO: HP_0000103
SIDER: C0042023
a hematopoietic disorder AE that results in the bone marrow producing too many red blood cells
SZ, SS, YH
polycythaemia vera AE
WEB: http://medical-dictionary.thefreedictionary.com/Polycythaemia+vera
10036057
polycythemia vera AE
a hypertension AE located in the heptatic portal system caused by obstruction or occlusion that produces splenomegaly and ascites in its later stages
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21129318
http://www.merriam-webster.com/medlineplus/portal%20hypertension
10036200
portal hypertension AE
CTCAE: E11238
HPO: HP_0001409
NCIt: C3119
SIDER: C0020541
a thrombosis AE that has an outcome of formation of a blood clot affecting the hepatic portal vein, can lead to hypertension or reduction of blood supply to the liver
SZ, SS, YH
PVT
WEB: http://medical-dictionary.thefreedictionary.com/portal+vein+thrombosis
10036206
portal vein thrombosis AE
CTCAE: E11243
NCIt: C78565
a syndrome that results in the patient suffering a set of problems after having a spinal tap procedure
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/19921503
10060854
post lumbar puncture syndrome AE
Fever AE that results in a fever occurring after an operation
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22774619
10050087
postoperative fever AE
A thrombosis AE that occurs after an operation that results in a blood clot in a blood vessel disrupting blood flow throughout the body
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/19756494
10050902
postoperative thrombosis AE
Female reproductive system AE that results in the patient getting pregnant even when using a contraceptive
SZ, SS, YH
10067667
pregnancy on contraceptive AE
a perinatal AE that has an outcome of premature baby
SZ, SS, YH
10036590
premature baby AE
a pregnancy AE that has an outcome of labor beginning prior to the 37th week of gestation
SZ, SS, YH
premature labour AE
preterm labor AE
WEB: http://wordnetweb.princeton.edu/perl/webwn?s=premature%20labor
10036600
premature labor AE
a sensory capability AE that has an outcome of a near-fainting episode which may include lightheadedness, dizziness, severe weakness, blurred vision, which may precede syncopal episode
SZ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/presyncope
10036653
presyncope AE
CTCAE:E12778
HPO: HP_0002321
NCIt:C80100
SIDER: C0700200
a bone disorder AE that has an outcome of a piece of dead bone that completely separates from sound bone during the process of necrosis
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/primary+sequestrum
10052460
primary sequestrum AE
a coronary artery disorder AE that results in cardiac pain at rest that occurs in cycles
SZ, SS, YH
Prinzmetal's angina AE
coronary vessel spasm AE
WEB: http://medical-dictionary.thefreedictionary.com/prinzmetal+angina
10036759
prinzmetal angina AE
HPO: HP_0001681
SIDER: C0002963
a digestive system AE that results in the pain located at the anus or in the rectum
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/proctalgia
10036772
proctalgia AE
HPO: HP_0004378
SIDER: C0034886
A medical intervention that is a procedure occuring in the inside structures of the tooth, including the dental pulp and tooth root, and the periapical tissue surrounding the root.
YH, SS
WEB: http://medical-dictionary.thefreedictionary.com/endodontic
10051085
endodontic procedure
A medical intervention that creates a passage of a tube through the nose or mouth into the trachea for maintenance of the airway, as during the administration of anesthesia.
YH, SS
WEB: http://medical-dictionary.thefreedictionary.com/Endotracheal+intubation
10067450
endotracheal intubation
A surgery that has an outcome of the removal of part or all of the stomach.
YH, SS
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002945.htm
10061965
gastrectomy
a cough AE that has an outcome of secretions that could be mucous or blood
SZ, SS, YH, MW
WEB: http://coldflu.about.com/od/glossary/g/productivecough.htm
10036790
productive cough AE
CTCAE:E13517
NCIt:C78569
a tumor AE that has an outcome of cancer that starts in the prostate gland, the small structure that wraps around the urethra carrying urine out of the body
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001418/
10060862
prostate cancer AE
HPO: HP_0012125
SIDER: C0376358
a physical examination result abnormal AE that results in a prostate exam being different than expected
SZ, SS, EB
10055025
prostate examination abnormal AE
a male reproductive system AE that has an outcome of an increased amount of prostatic specific antigen, a glycoprotein enzyme present in small quantities in the serum of men with healthy prostates. May indicate prostate cancer or prostate disorders
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23277770
10036975
prostatic specific antigen increased AE
a protein and chemistry analysis result abnormal AE that is characterized by the protein level in the body being abnormal
SZ, SS, YH, EB
10037012
protein total abnormal AE
a prothrombin level abnormal AE that is characterized by a decrease in level of prothrombin in body
SZ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/prothrombin
10037050
prothrombin level decreased AE
a prothrombin time abnormal AE that has an outcome of prolonged time for plasma in the blood to clot
SZ, SS, YH, EB
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003652.htm
10037063
prothrombin time prolonged AE
a digestive system AE that has an outcome of infection in the large intestine with an overgrowth of Clostridium difficile bacteria
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001305/
10037128
pseudomembranous colitis AE
HPO: HP_0002583
SIDER: C1257843
a bacterial infection AE that has an outcome of infection by genus Pseudomonas, typically targets respiratory tract
SZ, SS, YH
WEB: http://emedicine.medscape.com/article/970904-overview
10061471
pseudomonas infection AE
HPO: HP_0005429
SIDER: C0033817
a psychiatric disorder AE that results in physical pain being caused by the patient's life stresses
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/psychosomatic+disease
10049587
psychosomatic disease AE
A mental disorder AE that results in abnormal condition of the mind
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/psychotic+disorder
10061920
psychotic disorder AE
HPO: HP_0000709
SIDER: C0033975
an adverse event causality evidence that has an outcome of biological plausity.
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.
evidence of biological plausity of adverse event causality
a lung disorder AE that has an outcome of hypertension or abnormally high blood pressure in the arteries of the lungs
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001171/
10064911
pulmonary arterial hypertension AE
HPO: HP_0002092
SIDER: C2973725
a lung disorder AE that has an outcome of engorgement of pulmonary vessels with transudation of fluid into the alveolar and interstitial spaces, seen in cardiac disease, infections, and certain injuries
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/pulmonary+congestion
10037368
pulmonary congestion AE
HPO: HP_0004930
SIDER: C0242073
an arterial embolism AE that results in the blockage of the main artery of a lung or one of its branches by a substance that has travelled from elsewhere in the body through the bloodstream
[SS] moved by relation 'SubclassOf' from lung disorder AE to arterial embolism on 01/07/14
SZ, SS, YH
pulmonary artery thrombosis AE
pulmonary thrombosis AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23299609
10037340
10037377
10037437
pulmonary embolism AE
HPO: HP_0002204
SIDER: C0034065
a lung disorder AE wih the outcome of damaged or scarred lung tissue. Thickened tissue impairs lung function
SZ, SS, YH, MW
WEB: http://www.mayoclinic.com/health/pulmonary-fibrosis/DS00927
10037383
pulmonary fibrosis AE
CTCAE:E13527
HPO: HP_0002206
NCIt:C26869
SIDER: C0034069
a lung disorder AE that has an outcome of acute bleeding from the lung, especially in the upper respiratory tract and the endotracheal tube
SZ, SS, YH
pulmonary haemorrhage AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23217914
10037394
pulmonary hemorrhage AE
a lung disorder AE that has an outcome of abnormally high blood pressure in the arteris of the lungs
SZ, SS, YH, MW
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001171/
10037400
pulmonary hypertension AE
CTCAE:E13539
HPO: HP_0002092
NCIt:C3120
SIDER: C0020542
a lung disorder AE that has an outcome of an abnormal spot in the lungs that is more than 3 cm in size
SZ, SS, YH
WEB: http://lungcancer.about.com/od/whatislungcancer/a/Lung-Mass.htm
10056342
pulmonary mass AE
a lung disorder AE that has an outcome of edema or abnormal buildup of fluid in the air sacs of the lungs, leads to shortness of breath
MedDRA: 10037423 is for "pulmonary oedema"; MedDRA: 10037375 is for "pulmonary edema"
SZ, SS, YH, MW
pulmonary oedema AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001195/
pulmonary edema AE
CTCAE: E13521
HPO: HP_0100598
NCIt: C26868
SIDER: C0034063
UMLS CUI: C0034063
a cardiovascular disorder AE that has an outcome of an inability to detect pulse
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003078.htm
10037469
pulse absent AE
a cardiovascular disorder AE that has an outcome of abnormally low pulse pressure, less than 25% of systolic value. Can indicate blood loss or low stroke volume
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/pulse+pressure
10037480
pulse pressure decreased AE
an adverse event with an outcome of the release or secretion of pus
SZ, SS, YH
WEB: http://www.medterms.com/script/main/art.asp?articlekey=21858
10037569
purulent discharge AE
a kidney disorder AE that is characterized by the dilation of calices, usually due to obstruction or infection
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/calicectasis
10061927
pyelocaliectasis AE
an injury AE caused by ionizing radiation
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Radiation+Injuries
10037760
radiation injury AE
a digestive system AE that results in the inflammation of mucous membranes lining the digestive tract. Caused by radiation, can lead to mouth sores
SZ, SS, YH
WEB: http://www.medterms.com/script/main/art.asp?articlekey=19881
10037763
radiation mucositis AE
a digestive system AE that has an outcome of inflammation that radiation causes swelling of the esophagus
SZ, SS, YH
radiation oesophagitis AE
WEB: http://medical-dictionary.thefreedictionary.com/esophagitis
10048899
radiation esophagitis AE
a lung inflammation AE due to radiation therapy
SZ, SS, YH
WEB: http://www.medterms.com/script/main/art.asp?articlekey=8091
10037765
radiation pneumonitis AE
a skin AE that has an outcome of injury to the skin and underlying tissues from exposure to a large external dose of radiation
SZ, SS, YH
WEB: http://www.bt.cdc.gov/radiation/criphysicianfactsheet.asp
10063562
radiation skin injury AE
NCIt: C3349
a respiratory system AE that has an outcome of clicking, rattling or crackling noises made by one or both lungs during inhalation
SZ, SS, YH
Crackles
WEB: http://medical-dictionary.thefreedictionary.com/crackles
10037833
rales AE
a rash ae adverse event that results in redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin
SZ, SS, YH
rash erythematous AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23145421
10037855
erythematous rash AE
HPO: HP_0007432
SIDER: C0234913
a rash AE occuring in several areas of the body
SZ, SS, YH
rash (generalized) AE
rash generalised AE
WEB: http://www.freemd.com/rash-generalized/overview.htm
10037858
generalized rash AE
HPO: HP_0000988
SIDER: C0497365
a rash AE that has an outcome of an unpleasant sensation of the skin that provokes the uge to scratch
SZ, SS, YH
WEB: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/dermatology/pruritus-itch/
10037884
rash pruritic AE
an inflammation AE that has an outcome of an inflammatory reaction limited to a previously X-irradiated field when the patient is treated months/years later with certain drugs
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/7577597
10060856
recall phenomenon AE
Digestive System AE that results in bleeding in the rectal area
SZ, SS, YH
rectal haemorrhage AE
10038063
10038064
rectal hemorrhage AE
CTCAE: E10955
HPO: HP_0002573
NCIt: C27054
SIDER: C0267596
a red blood cell count abnormal AE that has an outcome of a decrease in red blood cells
SZ, SS, YH, EB
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003644.htm
10038153
red blood cell count decreased AE
HPO: HP_0001903
SIDER: C0427457
a digestive system disorder AE that results in the inflammation of the stomach lining due to reflux
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/gastritis
10057969
reflux gastritis AE
a digestive system AE located in the esophagus, can present with heartburn, and nausea, caused by gastroesophageal reflux disease
SZ, SS, YH
reflux oesophagitis AE
WEB: http://medical-dictionary.thefreedictionary.com/esophagitis
10038263
reflux esophagitis AE
HPO: HP_0100633
SIDER: C0014869
a kidney disorder AE that results in kidneys failing to adequately filter toxins and waste from the blood
SZ, SS, YH
kidney failure AE
renal insufficiency AE
WEB: http://medical-dictionary.thefreedictionary.com/renal+failure
10038435
renal failure AE
HPO: HP_0000083
SIDER: C0035078
a kidney disorder AE that results in the rapid loss or decline of kidney function
As shown on the renal.org website (http://www.renal.org/guidelines/modules/acute-kidney-injury), Acute kidney injury (AKI) has now replaced the term acute renal failure.
SZ, SS, YH, Izabela Birsanescu, MW
AKI
renal failure acute AE
WEB: http://medical-dictionary.thefreedictionary.com/acute+renal+failure
WEB: http://www.mayoclinic.org/diseases-conditions/kidney-failure/basics/definition/con-20024029
10038436
10069339
Acute kidney failure occurs when kidneys become unable to filter waste products from blood.
acute kidney injury AE
CTCAE:E12973
HPO: HP_0001919
NCIt:C26808
SIDER: C0022660
a kidney disorder AE that results in the kidneys failing to adequately filter toxins and waste from the blood
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23263712
10062237
renal impairment AE
HPO: HP_0000082
SIDER: C0341697
kidney disorder AE that results in the renal tubule wasting away and losing strength/functional abilities
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/nephron
10038536
renal tubular atrophy AE
a kidney disorder AE that results in the renal artery narrowing
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/renal+artery+stenosis
10038553
renal vessel disorder AE
Respiratory system AE that is characterized by conditions that affect organs and systems that deal with gas exchange
SZ, SS, YH
WEB: http://www.thefreedictionary.com/respiratory+disorder
10038683
respiratory disorder AE
HPO: HP_0002086
SIDER: C0035204
a respiratory system AE that has an outcome of a condition where lungs cannot remove all the carbon dioxide the body produces, makes body fluid too acidic
SZ, SS, YH
respiratory failure AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001154/
10038695
respiratory acidosis AE
CTCAE:E13545
HPO: HP_0004877
NCIt:C26872
SIDER: C1145670
a respiratory system AE that has an outcome of a ventilory rate greater than 20 breaths per minute
SZ, SS, YH
WEB: http://www.thefreedictionary.com/tachypnea
10038712
respiratory rate increased AE
Respiratory System AE that results in bleeding somewhere in the respiratory system
SZ, SS, YH
respiratory tract haemorrhage AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/8692086
10038727
respiratory tract hemorrhage AE
an infection AE that has an outcome of infection in the respiratory tract, includes pneumonia as well as lung abscess and acute bronchitis
SZ, SS, YH
WEB: http://www.thefreedictionary.com/respiratory+tract+infection
10062352
respiratory tract infection AE
HPO: HP_0002873
SIDER: C0035243
an eye disorder AE that has an outcome of bleeding in the eye
SZ, SS, YH
retinal haemorrhage AE
WEB: http://medical-dictionary.thefreedictionary.com/retinal+hemorrhage
10038867
retinal hemorrhage AE
HPO: HP_0000573
SIDER: C0035317
Eye Disorder AE that results in a tearing of retinal pigment epithelial tissue
SZ, SS, YH
10062971
retinal pigment epithelial tear AE
Amnesia AE that results in the patient forgeting things that happened before the onset of an injury or disease
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/retrograde+amnesia
10038965
retrograde amnesia AE
HPO: HP_0002354
SIDER: C0002624
an encephalopathy AE that is characterized by headache, confusion, seizures and visual loss, tends to resolve over time
SZ, SS, YH, MW
10063761
reversible posterior leukoencephalopathy syndrome AE
CTCAE:E12798
NCIt:C78598
a muscle adverse event that results in damaged skeletal muscle tissue breaks down rapidly
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/rhabdomyolysis
10039020
rhabdomyolysis AE
HPO: HP_0009045
SIDER: C0035410
a right ventricular dysfunction AE that has an outcome of congestive heart failure manifested by distention of the neck veins, enlargement of the liver, and dependent edema
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/right+ventricular+failure
10039163
right ventricular failure AE
HPO: HP_0001708
SIDER: C2939447
A pregnancy AE that results in the growing pregnancy in a woman's fallopian tube becoming larger than the tube and causing it to rupture
SZ, SS, YH
WEB: http://www.freemd.com/ruptured-ectopic-pregnancy/overview.htm
10048407
ruptured ectopic pregnancy AE
an abnormal salivary gland physiology AE that results in the salivary glands becoming irritated and/or swollen
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/salivaryglanddisorders.html
10061935
salivary gland disorder AE
HPO: HP_0010286
SIDER: C0036093
a skin AE that has an outcome of a hard coating formed during the wound healing reconstruction phase
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/scab
10039509
scab AE
HPO: HP_0007564
SIDER: C0205204
a nervous system AE that results in the sciatic nerve losing its sensory capabilities
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21995439
10039670
sciatic nerve injury AE
an eye disorder AE that is characterized by an excessive accumulation of blood in the eye
SZ, SS, YH
scleral hyperaemia AE
WEB: http://medical-dictionary.thefreedictionary.com/hyperaemia
10052130
scleral hyperemia AE
a dementia AE that results in an elderly patient suffering from dementia
SZ, SS, YH
10039966
senile dementia AE
a sensory capability AE that results in the patient feeling their blood flow
SZ, SS, YH
10039996
sensation of blood flow AE
a shock AE that has an outcome of life-threatening low blood pressure
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001689/
10040070
septic shock AE
HPO: HP_0002718
SIDER: C0036983
a surgery that leads to the excision of a sequestrum, or a piece of dead bone that has become separated during the process of necrosis
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/sequestrectomy
10053437
sequestrectomy
Blood cell lab test abnormal AE showing an increase in the number of immature leukocytes in peripheral blood. (in hematology) a predominance of immature leukocytes noted in a differential white blood cell count. It is usually indicative of an infection or inflammation. The term derives from a graph of blood components in which immature cell frequencies appear on the left side of the graph.
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/shift
10056383
shift to the left AE
a physiological shock AE that has an outcome of hypovolemic shock resulting from acute hemorrhage and characterized by hypotension, tachycardia, oliguria, and by pale, cold and clammy skin
SZ, SS, YH
shock haemorrhagic AE
WEB: http://medical-dictionary.thefreedictionary.com/hemorrhagic+shock
10049771
shock hemorrhagic AE
a gastrointestinal disorder AE that results in the sigmoid colon being inflamed
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/sigmoiditis
10052058
sigmoiditis AE
a respiratory system AE that has an outcome of disease in the air-filled spaces that surround the nasal cavity, above the eyes and behind the ethmoids
SZ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/paranasal+sinuses
10062244
sinus disorder AE
CTCAE:E13560
NCIt:C26843
a tachycardia AE that has an outcome of elevated impulses originating from the sinoatrial node, greater than 100 bpm
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/sinus+tachycardia
10040752
sinus tachycardia AE
CTCAE: E10214
HPO: HP_0001649
NCIt: C26889
SIDER: C0039239
a skin AE that is characterized by sore, cracked, or rough skin, usually on the hands, face and lips.
SZ, SS, YH
WEB: http://wellbeing.doctissimo.com/wellbeing-a-z/chapped-skin.html
10040813
skin chapped AE
a skin AE that results in linear-like cleavages in the skin
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/fissure
10040849
skin fissures AE
a skin AE that has an outcome of bleeding at the skin
SZ, SS, YH
skin haemorrhage AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003235.htm
10064265
skin hemorrhage AE
HPO: HP_0000967
SIDER: C0852361
a skin AE that has an outcome of darkening in an area of skin or nails caused by increased melanin
SZ, SS, YH, MW
WEB: http://medical-dictionary.thefreedictionary.com/hyperpigmentation
10040865
skin hyperpigmentation AE
CTCAE:E13718
HPO: HP_0010284
NCIt:C79731
SIDER: C0162834
a skin AE that has an outcome of infection. Can be bacterial, fungal, parasitic or viral
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/skin+infection
10040872
skin infection AE
CTCAE: E11568
HPO: HP_0001581
NCIt: C35025
SIDER: C0037278
a skin AE that has an outcome of a jagged wound, can be shallow cuts or deep gahes that penetrate through muscle to internal organs and bone
SZ, SS, YH
WEB: http://www.mdguidelines.com/lacerations
10058818
skin laceration AE
a skin AE that has an outcome of a superficial growth or patch of the skin that does not resemble the area surrounding it
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Skin+Lesions
10040882
skin lesion AE
HPO: HP_0011355
SIDER: C0037284
a skin AE that has an outcome of exposure of skin to nonspecific irritants or from the action of specific allergens
SZ, SS, YH
WEB: http://encyclopedia2.thefreedictionary.com/Skin+Reactions
10040914
skin reaction AE
a skin AE that has an outcome of irritation, sensitization and phototoxicity
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/dermal+toxicity
10059516
skin toxicity AE
a behavior and neurological AE that results in irregular sleep patterns
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/sleep+disorder
10040984
sleep disorder AE
HPO: HP_0002360
SIDER: C0851578
an eating disorder AE that is characterized by patient searching for food while asleep
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23205019
10067315
sleep-related eating disorder AE
a gastrointestinal disorder AE that has an outcome of a blockage that keeps substance from passing through the small intestine, may be caused by fibrous bands of tissue in the abdomen, inflamed/infected pouches in the intestine, or hernias and tumors
SZ, SS, YH
WEB: http://www.mayoclinic.com/health/intestinal-obstruction/DS00823
10041101
small intestinal obstruction AE
CTCAE: E11021
HPO: HP_0005214
NCIt: C78615
SIDER: C0235329
a surgery that is characterized by all of or part of the small intestine needing to be removed
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002943.htm
10041105
small intestinal resection
a gastrointestinal disorder AE in which the blood vessels in the small intestine narrow
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/stenosis
10062263
small intestinal stenosis AE
CTCAE: E11032
NCIt: C78617
a tumor AE that results in cancer in the small intestine
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/small+intestine+cancer
10054184
small intestine carcinoma AE
a gastrointestinal disorder AE that results in an ulcer in the patient's small intestine
SZ, SS, YH
10041133
small intestine ulcer AE
a connective tissue disorder AE that occurs in the non-skeletal tissue, usually subcutaneous and muscle tissue
SZ, SS, YH
WEB: http://www.reference.md/files/D018/mD018461.html
10062255
soft tissue infection AE
CTCAE: E11579
HPO: HP_0002719
NCIt: C79745
SIDER: C0149778
a connective tissue disorder AE that results in damage to muscles, ligaments, and tendons throughout the body
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22964676
10041291
soft tissue injury AE
a necrosis AE that results in necrosis occurring in soft tissue
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/necrosis
10065769
soft tissue necrosis AE
a behavior and neurological AE that results in the patient hvings a mental disorder with symptoms that may suggest physical illness or injury
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/somatoform+disorder
10054153
somatoform disorder AE
a bone disorder AE that has an outcome of vertebra collapse caused by small hairline fractures
SZ, SS, YH
WEB: http://www.webmd.com/osteoporosis/guide/spinal-compression-fractures-causes
10041541
spinal compression fracture AE
a nervious system AE that has an outcome of spinal cord compressed by bone fragments from a vertebral fracture, a tumor, abscess, ruptured intervertebral disc or other lesion
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/spinal+cord+compression
10041549
spinal cord compression AE
HPO: HP_0002176
SIDER: C0037926
Tumor AE that results in a tumor in the patient's spinal cord
SZ, SS, YH
10062261
spinal cord neoplasm AE
Spinal osteoarthritis AE is a osteoarthritis AE that has an outcome of degeneration of the protective cartilage that cushions the tops of bones, causes swelling and pain and may cause development of osteophytes.
SZ, SS, YH
WEB: http://www.webmd.com/osteoarthritis/guide/spinal-osteoarthritis-degenerative-arthritis-of-the-spine
10041591
spinal osteoarthritis AE
HPO: HP_0002758
SIDER: C0949690
an immune system disorder AE that has an outcome of a larger-than-normal spleen, affects blood filtration
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003276.htm
10041660
splenomegaly AE
HPO: HP_0001744
SIDER: C0038002
a microbiology and serology investigation result abnormal AE that has an outcome of bacterial infection in the lungs or breathing passages
SZ, SS, YH, EB
WEB: http://www.webmd.com/lung/sputum-culture
10051612
sputum culture positive AE
a respiratory system AE that shows increased sputum, which results in mucous material coughed up from the lungs by the patient.
SZ, SS, YH
WEB: http://www.medterms.com/script/main/art.asp?articlekey=5539
10041812
sputum increased AE
HPO: HP_0002105
SIDER: C0235567
a skin AE that has an outcome of a type of nonmelanoma skin cancer
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001832/
10041823
squamous cell carcinoma AE
HPO: HP_0006739
SIDER: C0007137
a bacterial infection AE that has an outcome of invasion by Staphylococcus, can present with pus, fever, chills and low blood pressure
SZ, SS, YH
WEB: http://www.medicinenet.com/staph_infection/page2.htm
10058080
staphylococcal infection AE
HPO: HP_0007499
SIDER: C0038160
a skin AE that results in the skin in the leg undergoing discoloration due to blood pooling as a result of insufficient venous return
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000834.htm
10041955
stasis dermatitis AE
a device occlusion AE that has an outcome of blockage of the stent, or a tube inserted into body to prevent or counteract a disease-induced, localized flow constriction
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002303.htm
10049936
stent occlusion AE
a skin adverse event that is characterized by cell death causing the epidermis to separate from the dermis
SZ, SS, YH, MW
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001854/
10042033
stevens-johnson syndrome AE
CTCAE:E13736
HPO: HP_0000951
NCIt:C79484
SIDER: C0038325
a stress AE that results in patient experiencing stress at work
SZ, SS, YH
10042210
stress at work AE
an adverse event causality evidence that comes from a case report.
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.
adverse event causality evidence from case report
a nervous system AE that has an outcome of bleeding in the area between the brain and the thin tissues that cover the brain
SZ, SS, YH
subarachnoid haemorrhage AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001720/
10042316
subarachnoid hemorrhage AE
HPO: HP_0002138
SIDER: C0038525
a nervous system AE that has an outcome of a collection of blood on the surface of the brain
SZ, SS, YH
subdural haematoma AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001732/
10042361
subdural hematoma AE
HPO: HP_0100309
SIDER: C0018946
A gastrointestinal hemorrhage AE that has an outcome of the bleeding in the stomach
YH, SS
gastric haemorrhage AE
10017788
10017789
gastric hemorrhage AE
CTCAE: E10706
NCIt: C54582
a death AE that has an outcome of unexpected death, 1 to 24 hours after the onset of symptoms
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/sudden+death
10042434
10042435
sudden death AE
CTCAE: E11171
HPO: HP_0001645
NCIt: C50911
SIDER: C0011071
a psychiatric disorder AE that results in thoughts about suicide
SZ, SS, YH, MW
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/Suicidal+ideation Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/10193592
10042458
suicidal ideation AE
CTCAE:E12964
NCIt:C80102
a psychiatric disorder AE that results in attempted suicide
SZ, SS, YH, MW
10042464
suicide attempt AE
CTCAE:E12969
HPO: HP_0000708
NCIt:C80111
SIDER: C0038663
a viral infection AE that has an outcome of a cell that was previously infected being coinfected with a different strain of the virus
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/superinfection
10042566
superinfection AE
HPO: HP_0005364
SIDER: C0038826
a venous thrombosis AE in which a stroke occurs as a result of thrombosis. uncommon cerebrovascular accident that is frequently associated with diseases that may contribute to the development of thrombosis through hypercoagulability, stasis of the local blood stream, and abnormalities of the vessel wall.
SZ, SS, YH
SSST
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1026412
WEB: http://www.ncbi.nlm.nih.gov/pubmed/1455986
10042567
superior sagittal sinus thrombosis AE
an arrhythmia AE that has an outcome of premature atrial contractions or beats caused by signals originating from ectopic atrial sites
SZ, SS, YH
WEB: http://sideeffects.embl.de/se/C0033036/
10042602
supraventricular extrasystoles AE
HPO: HP_0005115
SIDER: C0033036
a tachycardia AE that has an outcome of rapid heart rhythm originating at or above the atrioventricular node
SZ, SS, YH
WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001235/ Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23233691
10042604
supraventricular tachycardia AE
CTCAE: E10218
HPO: HP_0004765
NCIt: C35061
SIDER: C0039240
Adverse event that is characterized by the patient becoming increasingly suspicious
SZ, SS, YH
10042635
suspiciousness AE
an injury and procedural complication AE that results in a complication resulting from a suture
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/17276274
10059059
suture related complication AE
a surgery AE that results in a suture being used to hold body tissues together, ruptures
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21266279
10048547
suture rupture AE
an increased heartbeat AE that is characterized by a distburance of the heart rhythm in which heart rate is abnormally increased
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/tachyarrhythmia
10049447
tachyarrhythmia AE
HPO: HP_0001649
SIDER: C0080203
a tachycardia AE that results in tachycardia beginings and ending in an acute manner
SZ, SS, YH
WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/11208235 Secondary Source: http://www.nlm.nih.gov/medlineplus/ency/article/000183.htm
10043079
tachycardia paroxysmal AE
an abnormal repiration AE that shows an outcome of tachypnoea (i.e., abnormally rapid breathing or respiration)
SZ, SS, YH
tachypnoea AE
10043089
tachypnea AE
HPO: HP_0004346
SIDER: C0231835
an adverse event causality evidence that comes from the study of a case report series.
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.
adverse event causality evidence from case series
Behavior and neurological AE that results in the patient having recurring seizures
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001714/
10043209
temporal lobe epilepsy AE
An immune system disorder AE that is a complication that can occur after a stem or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body
YH, SS
GVHD
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001309.htm
10018651
graft versus host disease AE
a hematopoietic system AE that has an outcome of too many blood platelets or thrombocytes, can result in headache, lightheadedness, vision changes and limb numbness
SZ, SS, YH
thrombocythaemia AE
WEB: http://www.mayoclinic.com/health/thrombocythemia/DS01087
10015493
thrombocythemia AE
a hematopoietic system AE that has an outcome of decrease in platelets in the blood
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000586.htm
10043554
thrombocytopenia AE
HPO: HP_0001873
SIDER: C0040034
a phlebitis AE located in the vein, caused by a blood clot
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002098/
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001108.htm
10043570
thrombophlebitis AE
HPO: HP_0004418
SIDER: C0040046
a thrombosis AE that is characterized by a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22802583
WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/18215115 Secondary Source: http://www.nejm.org/doi/full/10.1056/NEJMra020528
10043645
thrombotic microangiopathy AE
HPO: HP_0002597
SIDER: C2717961
a tumor AE that results in a benign tumor in the thyroid
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004524/
10043688
thyroid adenoma AE
HPO: HP_0000854
SIDER: C0151468
a tumor AE that results in the patient hvings a mass growing in their thyroid
SZ, SS, YH
10058900
thyroid mass AE
an arrhythmia AE that has an outcome of an irregular rate of the heartbeat
YH, SS
10019304
heart rate irregular AE
HPO: HP_0011675
SIDER: C0237314
a syndrome AE that results in the patient suffering from withdrawal from not using tobacco
SZ, SS, YH
10059612
tobacco withdrawal symptoms AE
a tongue AE that has an outcome of open sores or cuts on the tongue
SZ, SS, YH
WEB: http://www.localhealth.com/article/tongue-ulcers
10043991
tongue ulceration AE
HPO: HP_0000155
SIDER: C0235351
Tumor AE that results in cancer in the patient's tonsils
SZ, SS, YH
10044002
tonsil cancer AE
a bone disorder AE that has an outcome of an abscess located in the tooth or a bacterial infection in the center of a tooth
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002055/
10044016
tooth abscess AE
HPO: HP_0000164
SIDER: C0518988
a bone disorder AE that has an outcome of disease in the teeth
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/toothdisorders.html
10044034
tooth disorder AE
HPO: HP_0000164
SIDER: C0040435
a bone disorder AE that has an outcome of a break or rupture in a bone
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/tooth+fracture
10062544
tooth fracture AE
a bone disorder AE that has an outcome of one or more teeth coming loose and falling out
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23253824
10044044
tooth loss AE
HPO: HP_0006349
SIDER: C0080233
a bone disorder AE that has an outcome of an aching pain in or around a tooth
SZ, SS, YH
odontalgia AE
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/toothache Seconday Source: http://www.ncbi.nlm.nih.gov/pubmed/22157099
10044055
toothache AE
CTCAE: E11054
HPO: HP_0000164
NCIt: C78640
SIDER: C0040460
a endocrine system AE that has an outcome of an excess production of thryoid hormone, characterized by functionally autonomous nodules
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000317.htm
10044242
toxic nodular goitre AE
A liver AE that has an outcome of an abnormal functionality of the liver
YH, SS
hepatic function abnormal AE
HPO: HP_0001410
SIDER: C0086565
a respiratory system AE that results in the trachea being infected by a bacteria
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001983/
10044302
10066798
tracheitis AE
CTCAE: E11599
NCIt: C78647
a respiratory system AE that is characterized by the inflammation of the muscous membranes of the trachea and bronchi
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/tracheobronchitis
10044314
tracheobronchitis AE
HPO: HP_0002837
SIDER: C0040586
a behavior and neurological AEthat results in the patient being in a state of trance
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/trance
10044334
trance AE
a transaminase level abnormal AE that has an outcome of elevated levels of alanine transaminase and aspartate transaminase
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Transaminases
10054889
transaminase level increased AE
A cardiomyopathy AE that has an outcome of a condition in which the heart muscle becomes thick. Often, only one part of the heart is thicker than the other parts. The thickening can make it harder for blood to leave the heart, forcing the heart to work harder to pump blood. It also can make it harder for the heart to relax and fill with blood.
YH, SS
HCM
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001243/
10020871
hypertrophic cardiomyopathy AE
HPO: HP_0001639
SIDER: C0007194
a vascular disorder AE that results in an abnormal spatial arrangement of any of the primary blood vessels
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002535/
10044443
transposition of the great vessels AE
a blood chloride abnormal AE that is characterized by an abnormally high level of chloride in the blood
YH, MW
10020599
hyperchloremia AE
UMLS CUI: C0085679
a cardiac valve disease AE that is characterized by a tricuspid valve that does not close tightly enough to prevent leakage
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Tricuspid+Valve+Insufficiency
10044640
tricuspid valve incompetence AE
a tri-iodothyronine level abnormal AE that results in a decreased level of tri-iodothyronine
SZ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/Tri-iodothyronine
10044594
tri-iodothyronine decreased AE
a troponin level abnormal AE that has an outcome of an increased amount of troponin, a protein released when the heart muscle is damaged
SZ, SS, YH, EB
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007452.htm
10058267
troponin level increased AE
a bacterial infection AE that is caused by M. tuberculosis.
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001141/
10044755
tuberculosis AE
a surgery that removes a tumour
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/Tumor+Removal
10061392
tumour excision
Tumor AE that results in a tumor reoccurring
SZ, SS, YH
tumour flare AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21523725
10045169
tumor flare AE
an hemorrhage AE that has an outcome of bleeding in the tumour
SZ, SS, YH
tumour haemorrhage AE
WEB: http://calder.med.miami.edu/pointis/tbifam/cause3.html
10049750
tumour hemorrhage AE
a syndrome AE that has an outcome of a group of metabolic complications that can occur after treatment of cancer
SZ, SS, YH
tumour lysis syndrome AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/15384972
10045152
10045170
tumor lysis syndrome AE
CTCAE: E12365
NCIt: C3425
a cytogenetic investigation result abnormal AE that has an outcome of an increase in a substance found in the blood, urine, or body tissues that can be elevated in cancer, among other tissue types
SZ, SS, YH, EB
tumour marker increased AE
WEB: http://www.cancer.gov/cancertopics/factsheet/detection/tumor-markers
10048621
tumor marker increased AE
a necrosis AE that has an outcome of death of tumor tissue, tumor rapidly outgrows its blood supply
SZ, SS, YH
tumour necrosis AE
WEB: http://medical-dictionary.thefreedictionary.com/tumor+necrosis
10054094
tumor necrosis AE
a keratitis AE that has an outcome of disrupted epithelial layer and stroma of the cornea, may become blind
SZ, SS, YH
corneal ulcer AE
WEB: http://medical-dictionary.thefreedictionary.com/Ulcerative+keratitis
10064996
ulcerative keratitis AE
HPO: HP_0007812
SIDER: C0010043
Homeostasis AE that results in an inability to achieve adequate fluid balance
SZ, SS, YH
10069568
ultrafiltration failure AE
Respiratory system AE that is characterized by the patient having an obstruction in their upper airway
SZ, SS, YH
10067775
upper airway obstruction AE
HPO: HP_0002781
SIDER: C0740852
a gastrointestinal hemorrhage AE that has an outcome of bleeding in the upper gastrointestinal tract
SZ, SS, YH
upper gastrointestinal haemorrhage AE
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/gastrointestinal+bleeding Secondary Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1237869/
10046274
10055356
upper gastrointestinal hemorrhage AE
CTCAE: E11062
HPO: HP_0002239
NCIt: C78660
SIDER: C0041909
a urinary system AE that has an outcome of a blockage in the urinary tract, can result in pain, fever, infection, loss of kidney function, sepsis or death if severe
SZ, SS, YH
WEB: http://www.mayoclinic.org/ureteral-obstruction/
10046406
ureteric obstruction AE
HPO: HP_0006000
SIDER: C0041956
Urinary system AE that results in the urethra becoming obstructed
SZ, SS, YH
10046459
urethral obstruction AE
HPO: HP_0000796
SIDER: C0041972
Urinary System AE that results in the urethra becoming narrowed at the external meatus
SZ, SS, YH
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/urethral+meatal+stenosis Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/22710090
10065584
urethral stenosis AE
a urinary incontinence AE that results in the patient feeling a sudden urgency or need to urinate.
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002250/
10046494
urge incontinence AE
HPO: HP_0000012
SIDER: C0150045
Urinary system AE that results in an inability to urinate
SZ, SS, YH, MW
WEB: Primary Source: http://medical-dictionary.thefreedictionary.com/urinary+retention Secondary Source: http://www.medtronic.com/patients/urinary-retention/index.htm
10046555
urinary retention AE
CTCAE:E13046
HPO: HP_0000016
NCIt:C50790
SIDER: C0080274
a urinary tract infection AE that results in the infection of the urinary tract by the Pseudomonas Aeruginosa organism
SZ, SS, YH
WEB: http://www.jiph.org/article/S1876-0341(09)00058-6/abstract
10062279
urinary tract infection pseudomonal AE
a urinary tract infection AE that results in the urinary tract being infected with the staphylococcal bacteria
SZ, SS, YH
10062280
urinary tract infection staphylococcal AE
a toxicology drug screen result abnormal AE that results in a positive result for amphetamines in the urine
SZ, SS, YH, EB
10051400
urine amphetamine positive AE
a urine abnormality AE that has an outcome of decreased urine output, less than 500 milliliters of urine in 24 hours
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003147.htm
10059895
urine output decreased AE
CTCAE: E12217
NCIt: C80522
a urinary system AE caused by an infection in the urinary tract that has an outcome of accumulation of pus-forming bacteria or toxins in the blood of the urinary tract.
SZ, SS, YH
WEB: http://www.primehealthchannel.com/urosepsis-definition-symptoms-causes-diagnosis-and-treatment.html
10048709
urosepsis AE
an urticaria AE that results in the appearance of "wheals" on skin
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/papular+urticaria
10046750
urticaria papular AE
a uterine AE that results in uterine contractions during pregnancy
SZ, SS, YH
10049975
uterine contractions during pregnancy AE
a uterine AE that has an outcome of bleeding from the uterus
MedDRA: 10046788 is for "uterine haemorrhage"; MedDRA: 10046789 is for "uterine hemorrhage"
SZ, SS, YH, MW
uterine haemorrhage AE
10046788
10046789
uterine hemorrhage AE
CTCAE: E13237
HPO: HP_0000130
NCIt: C78686
SIDER: C0042134
a uterine AE that results in the patient undergoing a single uterine contraction for over two minutes during pregnancy
SZ, SS, YH
WEB: Primary Source: http://www.ncbi.nlm.nih.gov/pubmed/12192488 Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/12192488
10046790
uterine hypertonus AE
HPO: HP_0000130
SIDER: C0269842
an infection AE that results in infection of the vagina
SZ, SS, YH
10046914
vaginal infection AE
CTCAE: E11624
HPO: HP_0000142
NCIt: C26911
SIDER: C0404521
a digestive system AE that has an outcome of dilated sub-mucosal veins in the lower third of the esophagus
SZ, SS, YH
varices oesophageal AE
WEB: http://www.mayoclinic.com/health/esophageal-varices/DS00820
10056091
varices esophageal AE
HPO: HP_0002040
SIDER: C0014867
a dementia AE that results in problems with reasoning, judgement, and memory resulting from brain damage from impaired blood flow to the brain
SZ, SS, YH
WEB: http://www.mayoclinic.com/health/vascular-dementia/DS00934
10057678
vascular dementia AE
a vascular disorder AE that results in the veins becoming discoloured
SZ, SS, YH
vein discolouration AE
10047183
vein discoloration AE
a thrombosis AE that has an outcome of a blood clot in the inferior vena cava
SZ, SS, YH
vena cava embolism AE
WEB: http://emedicine.medscape.com/article/1933035-overview, http://www.nlm.nih.gov/medlineplus/ency/article/000156.htm
10047193
10047195
vena cava thrombosis AE
a vascular disorder AE that results in an injury to the vein(s)
SZ, SS, YH
10047228
venous injury AE
CTCAE: E12051
NCIt: C78711
a thrombosis AE that has an outcome of a blood clot that forms within a vein
SZ, SS, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000156.htm
10047249
venous thrombosis AE
HPO: HP_0004850
SIDER: C0042487
a cardiac ventricular disorder AE that has an outcome of an abnormality in the contraction of the ventricles or the motion of the cells
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/ventricular+dysfunction
10059056
ventricular dysfunction AE
an adverse event causality evidence that comes from an uncontrolled observational study
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.
adverse event causality evidence from uncontrolled observational study
an ear disorder that results in irritation and swelling (inflammation) of the inner ear
SZ, SS, YH
lybyrinthitis AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002049/
10047393
vestibular neuronitis AE
an abnormal vision AE that results in unclear vision
SZ, SS, YH
blurred vision AE
WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/003029.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23111613
10005886
10047513
vision blurred AE
CTCAE: E10346
HPO: HP_0000622
NCIt: C27123
SIDER: C0344232
an abnormal vision AE that results in a decrease in clearness of vision
SZ, SS, YH
WEB: Primary Source: http://www.nlm.nih.gov/medlineplus/ency/article/003396.htm Secondary Source: http://www.ncbi.nlm.nih.gov/pubmed/23329671
10047531
visual acuity reduced AE
HPO: HP_0000572
SIDER: C0234632
an abnormal vision AE that results in the patient suffering from an enhanced brightness in their vision
SZ, SS, YH
10049155
visual brightness AE
a gustatory system AE that has an outcome of a shortage of vitamin D which is essential for strong bones
SZ, SS, YH
WEB: http://www.webmd.com/diet/vitamin-d-deficiency
10047626
vitamin d deficiency AE
HPO: HP_0100513
SIDER: C0042870
an adverse event causality evidence that comes from controlled observational studies.
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 29.
adverse event causality evidence from controlled observational study
Inflammation AE that is characterized by an inflammatory reaction of the vitreous or hyaloid membrane as a result of disease in adjacent structures
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/vitritis
10047663
vitritis AE
a physical examination result abnormal AE that shows an increase (gain) in weight of a patient
SZ, SS, YH
weight gain AE
10047896
10047899
weight increased AE
CTCAE: E12224
HPO: HP_0004324
NCIt: C62754
SIDER: C0043094
a conduction system disorder AE that results in an abnormal accessory electrical conduction pathway between the atria and ventricles
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001206/
10048015
wolff-parkinson-white syndrome AE
CTCAE: E10244
NCIt: C35132
a wound AE that has an outcome of complication to the wound
SZ, SS, YH
WEB: https://en.wikipedia.org/wiki/Wound
10053692
wound complication AE
CTCAE: E12057
NCIt: C78719
a wound AE that has an outcome of a wound breaking open along the surgical sutures
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/wound+dehiscence
10048031
wound dehiscence AE
CTCAE: E12063
NCIt: C50863
A wound AE that has an outcome of secretions or pus produced by damaged tissue particles and repairing mechanisms intitiated by the body
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/2815962
10048629
wound secretion AE
an abnormal vision AEthat results in the patient seeing a predominance of yellow in their vision
SZ, SS, YH
WEB: http://medical-dictionary.thefreedictionary.com/xanthopsia
10048216
xanthopsia AE
HPO: HP_0000551
SIDER: C0221185
an immune system disorder AE that results in a fungal infection of the sinuses, brain, or lungs that occurs in some people with a weakened immune system
SZ, SS, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001672/
10061418
zygomycosis AE
A cardiomyopathy AE that has an outcome of a heart failure with left ventricular dilatation resulting from ischemic heart disease.
YH, SS
ischaemic cardiomyopathy AE
WEB: http://medical-dictionary.thefreedictionary.com/ischemic+cardiomyopathy
10048858
ischemic cardiomyopathy AE
A surgery that is a procedure performed on the jaw
YH, SS
10059242
jaw operation
An adverse event that is a chronic neurological disorder caused by the brain's inability to regulate sleep-wake cycles normally.
YL
http://en.wikipedia.org/wiki/Narcolepsy
YL
narcolepsy AE
A medical intervention that is a life-support system designed to replace or support normal ventilatory lung function
YH, SS
WEB: www.medscape.com/resource/mechanical-ventilation
10067221
mechanical ventilation
An inflammation AE that has an outcome of tissue swelling and other inflammatory response in the mouth
YH, SS
oral mucositis
10028116
mucosal inflammation AE
A systematic adverse event that has an outcome of failure in mulitple organs
YH, SS
10028154
multi-organ failure AE
CTCAE: E11155
NCIt: C75568
Pleomorphic rash AE is rash AE that is a rash characterized by many-formed.
JX, LW, YH
多形性皮疹
pleomorphic rash AE
A bone disorder AE that has an outcome of the weakening or brittle bone
YH, SS, MW
WEB: http://www.mayoclinic.com/health/osteoporosis/DS00128
10031282
osteoporosis AE
CTCAE:E12508
HPO: HP_0000939
NCIt:C3298
SIDER: C0029456
A groupd of disroders where the genetic susceptibility plays an important role to the seletctive susceptibility to poorly pathogenic mycobacterial species such as bacille Calmette-Guérin and environmental mycobacteria.
MSMD
http://www.ncbi.nlm.nih.gov/pubmed/20718793
YL
Mendelian susceptibility to mycobacterial disease
A cardiomyopathy AE that has an outcome of a condition that the heart cannot relax normally during the time between heartbeats when the blood returns from the body (diastole).
YH, SS
infiltrative cardiomyopathy
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000189.htm
10038748
restrictive cardiomyopathy AE
CTCAE: E10192
NCIt: C62798
A medical intervention that has an outcome of the transplant of stem cells into the body
YH, SS
10063581
stem cell transplant
an adverse event causality evidence that comes from a controlled clincal trial
In a controlled clinical trial, outcomes are compared in subjects who are allocated by the investigator to receive or not receive a medical intervention.
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 30.
adverse event causality evidence from controlled clinical trial
A medical intervention that has an outcome of an intersion of a tube into the body
YH, SS
10048561
stent placement
A cardiomyopathy AE that is a temporary heart condition brought on by stressful situations, such as the death of a loved one. People with broken heart syndrome may have sudden chest pain or think they're having a heart attack. These broken heart syndrome symptoms may be brought on by the heart's reaction to a surge of stress hormones. In broken heart syndrome, a part of your heart temporarily enlarges and doesn't pump well, while the remainder of the heart functions normally or with even more forceful contractions.
YH, SS
takotsubo cardiomyopathy, broken heart syndrome, stress-induced cardiomyopathy, apical ballooning syndrome
WEB: http://www.mayoclinic.com/health/broken-heart-syndrome/DS01135/METHOD=print
10066286
stress cardiomyopathy AE
A medical intervention that has an outcome of an extraction of the tooth
YH, SS
10062132
tooth extraction
A skin adverse event that has an outcome of an eruption caused by ingestion, injection, inhalation, or insertion of a drug, often a result of allergic sensitization. Also called dermatitis medicamentosa, dermatosis medicamentosa, drug rash
YH, SS
dermatitis medicamentosa, dermatosis medicamentosa, drug rash
WEB: http://medical-dictionary.thefreedictionary.com/drug+eruption
10057970
toxic skin eruption AE
An arrythmia AE that has an outcome of a severely abnormal heart rhythm (arrhythmia) that can be life-threatening.
YH, SS
VF
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0004467/
10047290
ventricular fibrillation AE
CTCAE: E10236
HPO: HP_0001663
NCIt: C50799
SIDER: C0042510
an atrioventricular block AE that there is some prolongation of AV conduction time (PR interval). The heart's electrical signals are slowed as they move from the atria to the ventricles (the heart's upper and lower chambers, respectively). This results in a longer, flatter line between the P and the R waves on the EKG (electrocardiogram).
SS
atrioventricular block first degree
first degree heart block
WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751
WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html
10003674
first degree atrioventricular block AE
CTCAE: E10098
NCIt: C62015
A medical intervention that has an outcome of the removal of dead, damaged, dying or infected tissue. The human body is capable of (autolytic) debridement for small wounds, but for large wounds, medical procedures are necessary.
YH, SS
surgical debridement, enzymatic debridement, autolytic debridement, mechanical debridement
WEB: http://surgery.about.com/od/glossaryofsurgicalterms/g/Debridement.htm
10048030
wound debridement
A thyroiditis AE that is a self-limited thyroid condition associated with a triphasic clinical course of hyperthyroidism, hypothyroidism, and return to normal thyroid function.
SAT
http://emedicine.medscape.com/article/125648-overview
YL
subacute thyroiditis AE
Macrophagic myofasciitis (MMF) is a rare inflammatory muscle disorder characterized by a characteristic infiltration of muscle tissue by PAS-positive macrophages, which is caused by pathological persistence of vaccine-derived aluminium hydroxide. The diagnosis can only be established by an open muscle biopsy from the muscle that was used for intramuscular vaccination.
YL
MMF
http://www.ncbi.nlm.nih.gov/pubmed/14593574
YL
macrophagic myofasciitis AE
BCG infection following BCG injection. It is often related with the vaccinee's immunodeficiency.
YL
YL
disseminated BCG infection AE
An adverse event that is a disorder of neural development characterized by impaired social interaction and communication, and by restricted and repetitive behavior.
YL
http://en.wikipedia.org/wiki/Autism
autism AE
HPO: HP_0000717
SIDER: C0004352
an adverse event that is a type of encephalitis triggered by vaccination.
Autoimmune Encephalitis may be triggered by infection in which case the term "Post-infectious Encephalitis" is used. ADEM( Acute Disseminated Encephalomyelitis ) is a Post-infectious Encephalitis. The illness usually follows in the wake of a mild viral infection (such as those that cause rashes in childhood) or immunisations. Typically there is a delay of days to two to three weeks between the triggering infection and development of the encephalitis.
It has recently been recognised that there are other types of Autoimmune Encephalitis resulting from an attack of the brain by the body's immune system. Some of these types of autoimmune encephalitis are identified by finding a specific antibody in blood. These conditions include Potassium channel complex antibody associated encephalitis, NMDAR and Hashimoto's encephalitis.
http://www.encephalitis.info/information/the-illness/types-of-autoimmune-encephalitis/
YL
autoimmune encephalitis AE
an injection-site AE that display an redness in the injection-site
YH
injection-site redness AE
a sensory capability AE that shows up skin tenderness and occurs in an injection site of a medical intervention
YH
10043224
injection-site tenderness AE
YH
a movement disorder AE that has an outcome of arm motion limitation
arm motion limitation AE
a sensory capability AE that shows up muscular soreness at the injection site of a medical intervention
YH
10028332
injection-site muscular soreness AE
a sleep disorder AE that shows up sleepiness (Sluggish from sleep, inactive, quiet).
YH
10041014
sleepiness AE
an adverse event that occurs in brain.
YH
brain disorder AE
brain AE
a hypersensitivity AE that is mild.
YH
mild hypersensitivity AE
YH
an injection-site edema AE that occurs in the arm.
injection-site arm edema AE
a psychiatric disorder AE that shows restlessness
YH, MW
WEB: http://dictionary.reference.com/browse/restlessness
10038743
restlessness AE
CTCAE:E12960
NCIt:C74533
UMLS_CUI: C0085631
a sensory capability AE that results in a sensation of induration with tenderness.
YH
induration with tenderness AE
a sensory capability AE that results in a sensation of fussiness
YH
fussiness AE
a sleep disorder AE that shows decreased sleep
YH
decreased sleep AE
a sleep disorder AE that shows increased sleep
YH
increased sleep AE
a pain AE that occurs at a joint
YH
joint pain AE
Tiredness AE is a sensory capability AE that results in a sensation of tiredness.
This term appears to be a synonym to the 'fatigue AE'.
JX, LW, YH
hypodynamia AE
疲劳/乏力
10043890
tiredness AE
nasal discomfort AE is a respiratory system AE that shows a discomfort from the nose
YH
nasal discomfort AE
HPO: HP_0010640
SIDER: C0858259
an adverse event causal associate score that represents a statatical P-value to address the causal adverse event hypothesis.
YH
adverse event causality P-value
a data item that represents a statistic to summarize the extent to which a particular adverse event is observed for individuals taking a specific medical intervention (e.g., a drug), compared to the frequency at which the same adverse event occurs for patients taking some other intervention (e.g., other drug or any drug in a specified class of drugs).
The PRR will typically be calculated using a surveillance database in which reports of adverse events from a variety of drugs are recorded.
YH
PRR
WEB: http://www.ncbi.nlm.nih.gov/pubmed/11828828
proportional reporting ratio
an adverse event causality P-value that is calculated out of a specific Chi-square test.
YH
P-value of adverse event causality Chi-square test
a data item that represents a threshold cutoff for filtering out those adverse event case reports that are unlikely important for a specific AE study. This is applied to the analysis of AE case resport data in an AE case reporting system such as FAERS or VAERS.
YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23209624
adverse event filtering cutoff
A data item that is defined as the number of patients realized with an adverse event beginning in an interval or continuing from a previous interval divided by the number of patients taking the same medical intervention within that interval. The prevalence thus indicates the number of events that began and persisted over time.
AG, YH
WEB: http://www.crilifetree.com/pdfs/drug-safety/long-term-safety-study-of-morphine-sulfate-and-naltrexone-hydrochloride.pdf
AE prevalence rate
an imaging investigation result abnormal AE that is indicated by an abnormal result of a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body
EB
10029816
nuclear magnetic resonance imaging result abnormal AE
a computerized tomography abnormal AE that is an imaging method that uses x-rays to create pictures of cross-sections of the body using a dye, called oral contrast, that shows up on the CT images to help better define internal organs
EB
computerised tomogram with contrast abnormal AE
computerized tomogram with contrast abnormal AE
a computerized tomography abnormal AE that is an imaging method that uses x-rays to create pictures of cross-sections of the body
EB
computerised tomogram without contrast abnormal AE
computerized tomogram without contrast abnormal AE
an investigation result abnormal AE that involves an abnormal result of an investigation involving the cardiovascular system
EB, YH
10007512
cardiovascular investigation result abnormal AE
an atrioventricular block AE that some but not all atrial impulses fail to reach the ventricles, thus some ventricular beats are dropped. Electrical signals between the atria and ventricles are slowed to a large degree. Some signals don't reach the ventricles. On an EKG, the pattern of QRS waves doesn't follow each P wave as it normally would.
SS
atrioventricular block second degree
second degree heart block
WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751
WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html
10003677
second degree atrioventricular block AE
a cardiac and vascular investigation result abnormal AE that is an abnormal result of a test that uses sound waves to create a moving picture of the heart
EB
10061593
echocardiogram result abnormal AE
an investigation result abnormal AE that involves an abnormal electrolyte value
EB
10047843
electrolyte lab test abnormal AE
an electrolyte lab test abnormal AE that shows an abnormal blood phosphorus level
EB
10054823
blood phosphorus abnormal AE
A physical quality that has an increased level of phosphate in the blood
EB, YH, MW
10050196
blood phosphorus increased
HPO: HP_0002905
SIDER: C0919625
an atrioventricular block AE that complete atrioventricular dissociation occurs; atria and ventricles beat independently. None of the electrical signals reach the ventricles. This type also is called complete heart block or complete AV block.
When complete heart block occurs, special areas in the ventricles may create electrical signals to cause the ventricles to contract. This natural backup system is slower than the normal heart rate and isn't coordinated with the contraction of the atria. On an EKG, the normal pattern is disrupted. The P waves occur at a faster rate that isn't coordinated with the QRS waves.
SS
atrioventricular block complete
complete heart block
third degree atrioventricular block
third degree heart block
WEB: http://www.medilexicon.com/medicaldictionary.php?t=10751
WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html
10003673
complete atrioventricular block AE
CTCAE: E10093
NCIt: C50501
an electrolyte lab test abnormal AE that results in an abnormal level of potassium in the blood
EB
10005722
blood potassium abnormal AE
HPO: HP_0011042
SIDER: C0853759
a physical quality where the blood potassium level is increased.
EB, YH, MW
hyperkalemia AE
10005725
blood potassium increased
HPO: HP_0002513
SIDER: C0853760
an electrolyte lab test abnormal AE that results in an abnormal level of sodium in the blood
EB
10005800
blood sodium abnormal AE
A physical quality that has an increased level of sodium in the blood
EB, YH, MW
10005803
blood sodium increased
HPO: HP_0003228
SIDER: C0595878
an electrolyte lab test abnormal AE that results in an abnormal level of magnesium in the blood
EB
10005652
blood magnesium abnormal AE
A physical quality that has an increased level of magnesium in the blood
EB, YH, MW
10005655
blood magnesium increased
an electrolyte lab test abnormal AE that results in an abnormal level of chloride in the blood
EB
10005417
blood chloride abnormal AE
A physical quality that has an increased level of chloride in the blood
EB
10005420
blood chloride increased
an electrolyte lab test abnormal AE that results in an abnormal level of calcium in the blood
EB
10005393
blood calcium abnormal AE
A physical quality that has an increased level of calcium in the blood
EB, YH, MW
10005396
blood calcium increased
an investigation result abnormal AE that involves the renal and urinary tract and urinalyses
EB, YH
renal and urinary tract investigation and urinalysis result abnormal AE
renal system investigation result abnormal AE
10038362
urinary system investigation result abnormal AE
a urinary system investigation result abnormal AE that is characterized by an abnormal level of creatinine in the blood
EB
10005481
blood creatinine level abnormal AE
a urinary system investigation result abnormal AE that is characterized by an abnormal level of urea in the blood
EB
10005846
blood urea level abnormal AE
an investigation result abnormal AE that involves an abnormal result of a lipid analyses
EB
10024580
lipid analysis result abnormal AE
a lipid analysis result abnormal AE that results in an abnormal blood cholesterol level
EB
10005423
blood cholesterol abnormal AE
a blood cholesterol abnormal AE that results in a decreased amount of cholesterol in the blood
EB
10005424
blood cholesterol decreased AE
a lipid analysis result abnormal AE that is characterized by an abnormal amount of high density lipoprotein
EB
10020051
high density lipoprotein abnormal AE
a high density lipoprotein abnormal AE that is characterized by an increased amount of high density lipoprotein
EB
10020061
high density lipoprotein increased AE
a high density lipoprotein abnormal AE that is characterized by a decreased amount of high density lipoprotein
EB
10020060
high density lipoprotein decreased AE
HPO: HP_0003233
SIDER: C0151691
a lipid analysis result abnormal AE that is characterized by an abnormal amount of low density lipoprotein
EB
10024901
low density lipoprotein abnormal AE
a low density lipoprotein abnormal AE that is characterized by an increased amount of low density lipoprotein
EB
10024910
low density lipoprotein increased AE
HPO: HP_0003141
SIDER: C0549399
a low density lipoprotein abnormal AE that is characterized by a decreased amount of low density lipoprotein
EB
10024909
low density lipoprotein decreased AE
a lipid analysis result abnormal AE that is characterized by an abnormal amount of triglycerides in the blood
EB
10005837
blood triglycerides abnormal AE
a blood triglycerides abnormal AE that is characterized by an increased amount of triglycerides in the blood
EB
10005839
blood triglycerides increased AE
HPO: HP_0002155
SIDER: C0853692
a blood triglycerides abnormal AE that is characterized by a decreased amount of triglycerides in the blood
EB
10005838
blood triglycerides decreased AE
an investigation result abnormal AE that involves an abnormal result for an immunology and allergy investigation
EB
10021505
immunology and allergy investigation result abnormal AE
a second degree atrioventricular block AE that the electrical signals are delayed more and more with each heartbeat, until the heart skips a beat. On the EKG, the delay is shown as a line (called the PR interval) between the P and QRS waves. The line gets longer and longer until the QRS waves don't follow the next P wave.
MedDRA: 10050797 is a LLT for type I second degree atrioventricular block
MedDRA (LLT): 10047909 exists for Wenckebach phenomeono
MedDRA (LLT): 10047908 exists for Wenchebach
MedDRA (LLT): 10027787 for Mobit type I
SS, MW, YH
Mobitz type 1 block
Wenckebach Phenomenon
Wenckebach's block
type 1 second degree atrioventricular block
type I second degree atrioventricular block
WEB: https://www.nhlbi.nih.gov/health/health-topics/topics/hb/types
10027787
10047908
10047909
10050797
Mobitz type I block AE
CTCAE: E10146
NCIt: C62017
an immunology and allergy investigation result abnormal AE that is characterized by antibodies for epstein barr virus being detected
EB
10056906
epstein barr virus antibody positive AE
an immunology and allergy investigations result abnormal AE that is characterized by an abnormal microbiology and serology investigation
EB
10027529
microbiology and serology investigation result abnormal AE
a microbiology and serology investigation result abnormal AE that is characterized by a positive CSF culture
EB
10011529
CSF culture positive AE
an investigation result abnormal AE that involves an abnormal result of a metabolic and nutritional investigation
EB
10027432
metabolic and nutritional investigation result abnormal AE
a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal glycosylated hemoglobin level
EB
10055587
glycosylated hemoglobin level abnormal AE
a glycosylated hemoglobin level abnormal AE that is charaterized by an increased glycosylated hemoglobin level
EB
10055587
glycosylated hemoglobin level increased AE
a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood folate level
EB
10005525
blood folate level abnormal AE
a blood folate abnormal AE that is charaterized by an increased blood folate level
EB
10005528
blood folate level increased AE
a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood glucose level
EB
10005554
blood glucose level abnormal AE
a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood homocysteine
EB
10049735
blood homocysteine level abnormal AE
a blood homocysteine level abnormal AE that is charaterized by a decreased blood homocysteine
EB
10049734
blood homocysteine level decreased AE
a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal blood uric acid level
EB
10061727
blood uric acid level abnormal AE
a blood uric acid level abnormal AE that is characterized by a decreased blood uric acid
EB
10005860
blood uric acid level decreased AE
a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal vitamin B12 level
EB
10062187
vitamin B12 level abnormal AE
a vitamin B12 level abnormal AE that is characterized by an increased vitamin B12 level
EB
10047610
vitamin B12 level increased AE
a vitamin B12 level abnormal AE that is characterized by a decreased vitamin B12 level
EB
10047608
vitamin B12 level decreased AE
a metabolic and nutritional investigation result abnormal AE that is charaterized by an abnormal brain natriuretic peptide level
EB
10053408
brain natriuretic peptide level abnormal AE
a brain natriuretic peptide level abnormal AE that is characterized by an increased brain natriuretic peptide level
EB
10053405
brain natriuretic peptide level increased AE
a brain natriuretic peptide level abnormal AE that is characterized by a decreased brain natriuretic peptide level
EB
10053407
brain natriuretic peptide level decreased AE
a hematology investigation result abnormal AE that involves an abnormal result of the oxygen and carbon dioxide content of arterial blood, measured by various methods to assess the adequacy of ventilation and oxygenation and the acid-base status of the body
EB, SJ
WEB: http://medical-dictionary.thefreedictionary.com/arterial+blood+gas
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003855.htm
10005539
10027432
blood gases abnormal AE may be a result of lung, kidney, or metablolic diseases or the result of abnormal breathing after a head or neck injur
blood gas investigation result abnormal AE
a blood gas investigation result abnormal AE that is characterized by an abnormal amount of carbon dioxide in the blood
EB
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003469.htm
10064156
carbon dioxide abnormal AE
a carbon dioxide abnormal AE that is characterized by an increased carbon dioxide level in the blood
EB
10007225
carbon dioxide increased AE
HPO: HP_0005972
SIDER: C0860713
a blood gas investigation result abnormal AE that is characterized by an abnormal acidity or alkalinity of blood
EB
WEB: http://www.medterms.com/script/main/art.asp?articlekey=10001
10005705
blood pH abnormal AE
a blood pH abnormal AE that is characterized by an increased blood pH
EB
10005708
blood pH increased AE
a blood pH abnormal AE that is characterized by a decreased blood pH
EB
10005706
blood pH decreased AE
an adverse event causality evidence that comes from the combined evidence sources
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 28.
adverse event causality evidence from combined sources
a blood gas investigation result abnormal AE that is characterized by an abnormal oxygen saturation in the blood
EB
10033317
oxygen saturation abnormal AE
an oxygen saturation abnormal AE that is characterized by an increased percentage of hemoglobin binding sites in the bloodstream occupied by oxygen
EB
10033320
oxygen saturation increased AE
a blood gas investigation result abnormal AE that is characterized by an abnormal carbon dioxide partial pressure or tension in the blood
EB
WEB: http://medical-dictionary.thefreedictionary.com/PCO2
10058982
PCO2 abnormal AE
a PCO2 abnormal AE that is characterized by an increased carbon dioxide partial pressure or tension in the blood
EB
10034183
PCO2 increased AE
a pPCO2 abnormal AE that is characterized by a decreased carbon dioxide partial pressure or tension in the blood
EB
10034181
PCO2 decreased AE
a blood gas investigation result abnormal AE that is characterized by an abnormal oxygen partial pressure in the blood
EB
WEB: http://medical-dictionary.thefreedictionary.com/PO2
10062087
PO2 abnormal AE
a PO2 abnormal AE that is characterized by an increased oxygen partial pressure in the blood
EB
10035769
PO2 increased AE
a PO2 abnormal AE that is characterized by a decreased oxygen partial pressure in the blood
EB
10035768
PO2 decreased AE
an investigation result abnormal AE that results from an abnormal toxicology screen
EB
10044260
toxicology drug screen result abnormal AE
a toxicology drug screen result abnormal AE that is characterized by positive barbiturates
EB
10063230
barbiturates positive AE
a toxicology drug screen result abnormal AE that is characterized by positive cocaine
EB
10063230
cocaine positive AE
a second degree atrioventricular block AE that some of the electrical signals don't reach the ventricles. However, the pattern is less regular than it is in Mobitz type I. Some signals move between the atria and ventricles normally, while others are blocked.
On an EKG, the QRS wave follows the P wave at a normal speed. Sometimes, though, the QRS wave is missing (when a signal is blocked).
SS, YH, MW
Mobitz (type) II atrioventricular block AE
Mobitz type 2 block
type 2 second degree atrioventricular block
type II second degree atrioventricular block
WEB: http://www.nhlbi.nih.gov/health//dci/Diseases/hb/hb_types.html
10027786
10050798
Mobitz type II block AE
CTCAE: E10140
NCIt: C62018
a toxicology drug screen result abnormal AE that is characterized by increased urine cannabinoids
EB
10062228
urine cannabinoids increased AE
an investigation result abnormal AE that involves an abnormal result of a neurological, special senses and psychiatric investigation
EB
neurological, special senses and psychiatric investigation result abnormal AE
10029295
behavioral and neurological test abnormal AE
an investigation result abnormal AE resulting from an abnormal physical examination finding
EB
10062078
10071940
physical examination result abnormal AE
an investigation result abnormal AE that involves an abnormal result of an investigation related to chromosomal abnormalities and pathologic conditions
EB
WEB: http://medical-dictionary.thefreedictionary.com/Cytogenetic+analysis
10011822
cytogenetic investigation result abnormal AE
an investigation result abnormal AE that involves an abnormal respiratory and pulmonary investigation
EB
10038668
respiratory and pulmonary investigation result abnormal AE
an investigation result abnormal AE that involves an abnormal result of an endocrine investigation
EB
10014706
endocrine investigation result abnormal AE
an adverse event causality evidence that comes from a randomized controlled clincal trial where a medical intervention is conducted in a random fashion
In a controlled clinical trial, outcomes are compared in subjects who are allocated by the investigator to receive or not receive a medical intervention.
YH
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 30.
adverse event causality evidence from randomized clinical trial
an endocrine investigation result abnormal AE that is characterized by an abnormal blood parathyroid hormone level
EB
10005700
blood parathyroid hormone level abnormal AE
a blood parathyroid hormone level abnormal AE that is characterized by an increased blood parathyroid hormone level
EB
10005703
blood parathyroid hormone increased AE
an endocrine investigation result abnormal AE that is characterized by an abnormal tri-iodothyronine level
EB
10044592
tri-iodothyronine level abnormal AE
a tri-iodothyronine level abnormal AE that is characterized by an increased tri-iodothyronine level
EB
10044596
tri-iodothyronine increased AE
an investigation result abnormal AE that involves an abnormal protein and chemistry analysis result
EB
10037000
protein and chemistry analysis result abnormal AE
a protein and chemistry analysis result abnormal AE that is characterized by an abnormal blood albumin level
EB
10005286
blood albumin level abnormal AE
a blood albumin level abnormal AE that is characterized by an increased blood albumin level
EB
10005288
blood albumin level increased AE
a protein and chemistry analysis result abnormal AE that is characterized by an abnormal c-reactive protein level
EB
10068559
c-reactive protein level abnormal AE
a c-reactive protein level abnormal AE that is characterized by a decreased c-reactive protein level
EB
10049220
c-reactive protein level decreased AE
a protein total abnormal AE that is characterized by an increased protein total
EB
10037016
protein total increased AE
a protein total abnormal AE that is characterized by a decreased protein total
EB
10037014
protein total decreased AE
a cardiac and vascular investigation result abnormal AE that involves an abnormal result from a test using a radioactive tracer (called a radionuclide) and a special camera to take pictures of your heart as it pumps blood
EB
WEB: http://www.heart.org/HEARTORG/Conditions/HeartAttack/SymptomsDiagnosisofHeartAttack/Radionuclide-Ventriculography-or-Radionuclide-Angiography-MUGA-Scan_UCM_446354_Article.jsp
10028146
MUGA scan result abnormal AE
a cardiac function test abnormal AE that shows an abnormal result on a cardiac stress test.
EB, YH
WEB: http://medical-dictionary.thefreedictionary.com/Stress+Test
WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures
10055014
cardiac stress test result abnormal AE
an investigation result abnormal AE that is characterized by an abnormal result of an enzyme investigation
EB
10014938
enzyme investigation result abnormal AE
a blood creatine phosphokinase level abnormal AE that is characterized by a decreased blood creatine phosphokinase
EB
10067760
blood creatine phosphokinase level decreased AE
an investigation result abnormal AE that is characterized by an abnormal result of a hematology investigation
EB
MedDRA: 10057755
haematology investigation abnormal AE
10018851
hematology investigation result abnormal AE
a hematology investigation result abnormal AE that results in an abnormal red blood cell profile
EB
20000029
red blood cell profile abnormal AE
a hematology investigation result abnormal AE that is characterized by an abnormal white blood cell profile
EB
20000030
white blood cell profile abnormal AE
a white blood cell profile abnormal AE that is characterized by an abnormal percentage of neutrophils
EB
10058134
neutrophil percentage abnormal AE
a neutrophil percentage abnormal AE that is characterized by a decreased percentage of neutrophils
EB
10052223
neutrophil percentage decreased AE
a white blood cell profile abnormal AE that is characterized by an abnormal basophil count
EB
10060978
basophil count abnormal AE
a basophil count abnormal AE that is characterized by a decreased basophil count
EB
10004167
basophil count decreased AE
a white blood cell profile abnormal AE that is characterized by an abnormal eosinophil percentage
EB
10058133
eosinophil percentage abnormal AE
an eosinophil percentage abnormal AE that is characterized by a decreased eosinophil percentage
EB
10052221
eosinophil percentage decreased AE
a white blood cell profile abnormal AE that is characterized by an abnormal leukocyte cell number
EB
leukocyte cell number abnormal AE
a white blood cell profile abnormal AE that is characterized by an abnormal granulocyte count
EB
10018678
granulocyte count abnormal AE
a granulocyte count abnormal AE that is characterized by an increased granulocyte count
EB
10018683
granulocyte count increased AE
a white blood cell profile abnormal AE that is characterized by an abnormal lymphocyte cell number
EB
10025252
lymphocyte count abnormal AE
a white blood cell profile abnormal AE that is characterized by an abnormal lymphocyte percentage
EB
lymphocyte percentage abnormal AE
a white blood cell profile abnormal AE that is characterized by an abnormal monocyte percentage
EB
10067238
monocyte percentage abnormal AE
a monoctyte percentage abnormal AE that is characterized by a decreased monocyte percentage
EB
10052229
monocyte percentage decreased AE
an enzyme investigation result abnormal AE that is characterized by an abnormal blood lactate dehydrogenase level
EB
10005627
blood lactate dehydrogenase level abnormal AE
a blood lactate dehydrogenase level abnormal AE that is characterized by a decreased blood lactate dehydrogenase
EB
10005629
blood lactate dehydrogenase level decreased AE
an enzyme investigation result abnormal AE that is characterized by an abnormal troponin level
EB
troponin level abnormal AE
an enzyme investigation result abnormal AE that is characterized by an abnormal muscle enzyme level
EB
muscle enzyme level abnormal AE
a muscle enzyme level abnormal AE that is characterized by a decreased muscle enzyme level
EB
10057952
muscle enzyme level decreased AE
an enzyme investigation result abnormal AE that is characterized by an abnormal myoglobin level in the blood
EB
myoglobin blood abnormal AE
a myoglobin blood abnormal AE that is characterized by an increased myoglobin level in the blood
EB
10028625
myoglobin blood increased AE
a myoglobin blood abnormal AE that is characterized by a decreased myoglobin level in the blood
10059940
myoglobin blood decreased AE
an investigation result abnormal AE that is characterized by an abnormal result of a gastrointestinal investigation
EB
10017971
gastrointestinal investigation result abnormal AE
a gastrointestinal investigation result abnormal AE that is characterized by an abnormal blood amylase level
EB
10054822
blood amylase level abnormal AE
a blood amylase level abnormal AE that is characterized by a decreased blood amylase level
EB
10005327
blood amylase level decreased AE
a gastrointestinal investigation result abnormal AE that is characterized by an abnormal lipase level
EB
10054821
lipase level abnormal AE
a lipase level abnormal AE that is characterized by an increased lipase level
EB
10024574
lipase level increased AE
a lipase level abnormal AE that is characterized by a decreased lipase level
EB
10024573
lipase level decreased AE
an investigation result abnormal AE that is characterized by an abnormal liver related investigation result
EB
20000008
liver related investigation result abnormal AE
a liver related investigation result abnormal AE that is characterized by an abnormal level of transaminases
EB
10062688
transaminase level abnormal AE
a transaminase level abnormal AE that is characterized by a decreased level of transaminases
EB
10054795
transaminase level decreased AE
a liver related investigation result abnormal AE that is characterized by an abnormal aspartate aminotransferase level
EB
10003477
aspartate aminotransferase level abnormal AE
an aspartate aminotransferase level abnormal AE that is characterized by a decreased aspartate aminotransferase level
EB
10003479
aspartate aminotransferase level decreased AE
a gamma-glutamyltransferase level abnormal AE that is characterized by a decreased gamma-glutamyltransferase level
EB
10017690
gamma-glutamyltransferase level decreased AE
a blood bilirubin level abnormal AE that is characterized by a decreased blood bilirubin level
EB
10049869
blood bilirubin level decreased AE
an investigation result abnormal AE that is characterized by an abnormal result of an imaging investigation
EB
10022893
imaging investigation result abnormal AE
a hematology investigation result abnormal AE that is characterized by an abnormal blood thromboplastin level
EB
10005824
blood thromboplastin level abnormal AE
a blood thromboplastin level abnormal AE that is characterized by a decreased blood thromboplastin level
EB
10005826
blood thromboplastin level decreased AE
a hematology investigations result abnormal AE that is characterized by an abnormal coagulation factor v level
EB
10061771
coagulation factor v level abnormal AE
a coagulation factor v level abnormal AE that is characterized by an increased coagulation factor v level
EB
10009756
coagulation factor v level increased AE
a hematology investigation result abnormal AE that is characterized by an abnormal prothrombin level
EB
10037048
prothrombin level abnormal AE
a prothrombin level abnormal AE that is characterized by an increased prothrombin level
EB
10037051
prothrombin level increased AE
HPO: HP_0003645
SIDER: C0151872
a hematology investigation result abnormal AE that is characterized by an abnormal prothrombin time
EB
10037057
prothrombin time abnormal AE
a prothrombin time abnormal AE that is characterized by a shortened prothrombin time
EB
10037070
prothrombin time shortened AE
a full blood count abnormal AE that is characterized by an increased full blood count
EB
10052239
full blood count increased AE
a red blood cell profile abnormal AE that is characterized by an abnormal red blood cell count
EB
10038151
red blood cell count abnormal AE
a red blood cell count abnormal AE that is characterized by an increased red blood cell count
EB
10038155
red blood cell count increased AE
a red blood cell profile abnormal AE that is characterized by an abnormal hematocrit
EB
10057763
hematocrit abnormal AE
a hematocrit abnormal AE that is characterized by an increased hematocrit
EB
10019424
hematocrit increased AE
a hemoglobin level abnormal AE that is characterized by an increased hemoglobin level
EB
10055599
hemoglobin level increased AE
CTCAE: E12171
NCIt: C78333
a red blood cell profile abnormal AE that is characterized by an abnormal mean corpuscular volume
EB
10027009
mean corpuscular volume abnormal AE
a mean corpuscular volume abnormal AE that is characterized by an increased mean corpuscular volume
EB
10051859
mean corpuscular volume increased AE
a mean corpuscular volume abnormal AE that is characterized by a decreased mean corpuscular volume
EB
10051858
mean corpuscular volume decreased AE
a red blood cell profile abnormal AE that is characterized by an abnormal mean cell hemoglobin level
EB
mean cell hemoglobin level abnormal AE
a mean cell hemoglobin level abnormal AE that is characterized by an increased mean cell hemoglobin level
EB
10055622
mean cell hemoglobin level increased AE
a mean cell hemoglobin level abnormal AE that is characterized by a decreased mean cell hemoglobin level
EB
10055621
mean cell hemoglobin level decreased AE
a red blood cell profile abnormal AE that is characterized by an abnormal mean cell hemoglobin concentration
EB
10067730
mean cell hemoglobin concentration abnormal AE
a mean cell hemoglobin concentration abnormal AE that is characterized by an increased mean cell hemoglobin concentration
EB
10026992
mean cell hemoglobin concentration increased AE
a mean cell hemoglobin concentration abnormal AE that is characterized by a decreased mean cell hemoglobin concentration
EB
10026991
mean cell hemoglobin concentration decreased AE
a conduction system disorder that refers to abnormalities in SN impulse formation and propagation and includes sinus bradycardia, sinus pause/arrest, chronotropic incompetence, and sinoatrial exit block.
SS
SND
sinus node dysfunction
WEB: http://emedicine.medscape.com/article/158064-overview
sinoatrial node dysfunction AE
a coronary artery disorder AE that takes place in or is related to the coronary inside the heart
Even though 'coronary disorder AE' seems to be a more general term of 'coronary artery disorder AE' that should place 'coronary disorder AE' as a parent of 'coronary artery disorder AE', KB's comment from clinical perspective is that these two terms are synonymous in practice, and coronary disorder almost always means coronary artery disorder. If 'coronary disorder AE' gets picked up from reports, it is a generalized term of 'coronary artery disorder AE'; and thereofore, we created a place holder for this term under 'coronary artery disorder AE'
SS
coronary disorder AE
a myocardial infarction AE in which the inferior wall of the heart is involved. It is often caused by occlusion of the right coronary artery.
SS
myocardial infarction, inferior wall AE
WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=inferior+wall+myocardial+infarction
inferior wall myocardial infarction AE
a myocardial infarction AE in which the anterior wall of the heart is involved. Anterior wall myocardial infarction is often caused by occlusion of the left anterior descending coronary artery. It can be categorized as anteroseptal or anterolateral wall myocardial infarction.
SS
myocardial infarction, anterior wall AE
WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=anterior+wall+myocardial+infarction
anterior wall myocardial infarction AE
a hematology investigation result abnormal AE that is characterized by an abnormal blast cell count
EB
blast cell count abnormal AE
a blast cell count abnormal AE that is characterized by a decreased blast cell count
EB
10062275
blast cell count decreased AE
a hematology investigation result abnormal AE that is characterized by an abnormal platelet count
EB
10035526
platelet count abnormal AE
HPO: HP_0011873
SIDER: C0580317
a platelet count abnormal AE that is characterized by an increased platelet count
SZ, SS, YH, EB
WEB: http://medical-dictionary.thefreedictionary.com/thrombocytosis
10051608
platelet count increased AE
a white blood cell profile abnormal AE that is characterized by an abnormal eosinophil count
EB
10061125
eosinophil count abnormal AE
an eosinophil count abnormal AE that is characterized by a decreased eosinophil count
EB
10014943
eosinophil count decreased AE
a hypertension AE that is characterized by high blood pressure in the systemic arteries - the vessels that carry blood from the heart to the body's tissues (other than the lungs).
SS
WEB: http://www.pted.org/?id=syshypertension1
systemic hypertension AE
a hypotension AE that has an outcome of a decrease in the amount of pressure the heart generates when pumping blood through arteries to the rest of the body
SS
WEB: http://www.mayoclinic.com/health/low-blood-pressure/DS00590/DSECTION=causes
10005758
blood pressure systolic decreased AE
HPO: HP_0006673
SIDER: C0277885
a cardiac valve disease AE that is characterized by an impaired function of a papillary muscle, usually due to ischemia or infarction, with resulting incompetence of the mitral (rarely tricuspid) valve.
SS
papillary muscle dysfunction
papillary muscle syndrome
WEB: http://medical-dictionary.thefreedictionary.com/papillary+muscle+dysfunction
10061330
papillary muscle disorder AE
a hypertension AE that has an outcome of an increase in the amount of pressure in the arteries when the heart is at rest between beats
SS
WEB: http://www.webmd.com/hypertension-high-blood-pressure/guide/diastolic-and-systolic-blood-pressure-know-your-numbers
10005739
blood pressure diastolic increased AE
HPO: HP_0005117
SIDER: C0277889
a hypertension AE that has an outcome of an increase in the amount of pressure the heart generates when pumping blood through arteries to the rest of the body
SS
WEB: http://www.webmd.com/hypertension-high-blood-pressure/guide/diastolic-and-systolic-blood-pressure-know-your-numbers
10005760
blood pressure systolic increased AE
HPO: HP_0004421
SIDER: C0277884
a cardiac ventricular disorder AE that is a condition in nwhich the right ventricle of the heart was functionally impaired. This condition usually leads to heart failure or myocardial infarction, and other cardiovascular complicationns.
SS
WEB: http://www.ncbi.nlm.nih.gov/mesh/?term=right%20ventricular%20dysfunction
10058597
right ventricular dysfunction AE
CTCAE: E10196
NCIt: C50733
an arrhythmia AE that is characterized by a premature contraction of the ventricle
SS
infranodal extrasystoles AE
WEB: http://dictionary.reference.com/browse/ventricular+extrasystole
10047289
ventricular extrasystoles AE
HPO: HP_0006696
SIDER: C0151636
an embolism disorder AE that is a result of an obstruction in a cardiac vessel due to a blood clot or other foreign matters
SS
heart embolism AE
WEB: http://medical-dictionary.thefreedictionary.com/Heart+embolism
cardiac embolism AE
a vascular disorder AE that is characterized by an obstruction in a blood vessel due to a blood clot or other foreign matter that gets stuck while traveling through the bloodstream.
SS
WEB: http://medical-dictionary.thefreedictionary.com/embolism
栓塞
10014523
embolism AE
HPO: HP_0001907
SIDER: C0013922
an adverse event causity that represents a retrodictrive causal relation between an adverse event and a medical intervention. Specifically, it addresses this question: given an individual who has received a medical intervention and developed the adverse event, was the event caused by the medical intervention?
YH
retrodictive causality of adverse event
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20.
retrodictive AE causality
an arrhythmia AE that results in extra, abnormal heartbeats that begin in one of the heart's two lower pumping chambers (ventricles). These extra beats disrupt the regular heart rhythm, sometimes causing the patient to feel a flip-flop or skipped beat in the chest.
SS
PVCs
WEB: http://www.mayoclinic.com/health/premature-ventricular-contractions/DS00949
10036614
premature ventricular contractions AE
a cardiac valve disease AE that is charaterized by the backflow of blood from the pulmonary artery into the right ventricle, owing to imperfect functioning of the pulmonary valve
SS
pulmonic incompetence AE
WEB: http://www.rightdiagnosis.com/medical/pulmonary_valve_incompetence.htm
10037448
pulmonary valve incompetence AE
HPO: HP_0010444
SIDER: C0034088
a cardiac vavle disease AE that is characterized by a congenital heart defect in which blood flow from the heart to the pulmonary artery is blocked
SS
pulmonic stenosis AE
WEB: http://medical-dictionary.thefreedictionary.com/Pulmonary+Valve+Stenosis
10037450
pulmonary valve stenosis AE
a vasculitis AE that is an inflammation specific to an artery or arteries
SS
WEB: http://medical-dictionary.thefreedictionary.com/arteritis
10003230
arteritis AE
HPO: HP_0005291
SIDER: C0003860
a process quality that represents the level of severity of an adverse event.
YH, SS
AE severity
severity of adverse event
a vascular disorder AE that results in an abnormal widening or ballooning of a portion of an artery due to weakness in the wall of the blood vessel
SS
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001122.htm
10002329
aneurysm AE
HPO: HP_0002617
SIDER: C0002940
a vascular disorder that affects the veins or blood circulation of the veins
SS
venous disorder AE
an aneurysm AE that results in the weakening of the balloon-like bulge that the blood pressure causes the artery wall to leak or burst
SS
SAH
ruptured aneurysm AE
subarachnoid hemorrhage AE
WEB: http://www.mayfieldclinic.com/PE-AneurRupt.htm#.Uor4tI3QHh0
10048380
aneurysm ruptured AE
HPO: HP_0002617
SIDER: C0162869
an aneurysm AE that refers to an aneurysm involving cardiac tissue. This most often occurs as a ventricular aneurysm following a myocardial infarction
SS
aneurysm of heart AE
heart aneurysm AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/19239694
10007513
cardiac aneurysm AE
an aneurysm AE that occurs in the aorta
SS
WEB: http://www.webmd.com/heart-disease/tc/aortic-aneurysm-overview
10002882
aortic aneurysm AE
HPO: HP_0004942
SIDER: C0003486
an aneurysm ruptured AE that occurs in the aorta
SS
ruptured aortic aneurysm AE
10002886
aortic aneurysm rupture AE
HPO: HP_0002622
SIDER: C0741160
an aortic disorder AE in which there is a separation of the aorta walls. The small tear can become larger. It can lead to bleeding into and along the wall of the aorta, the major artery carrying blood out of the heart.
SS
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000181.htm
10002895
aortic dissection AE
HPO: HP_0004933
SIDER: C0340643
an aneurysm ruptured AE that occurs in the brain where blood spurts into the subarachnoid space under arterial pressure, continuing until increased local or generalized intracranial pressure stops the bleeding.
SS
WEB: http://ether.stanford.edu/library/neuroanesthesia/Journal%20Articles/Ruptured%20cerebral%20aneurysms.pdf
WEB: http://www.ncbi.nlm.nih.gov/pubmed/15647574
10039330
ruptured cerebral aneurysm AE
an aneurysm AE that occurs in the brain
SS
brain aneurysm AE
cerebral aneurysm AE
intracerebral aneurysm AE
WEB: http://www.ninds.nih.gov/disorders/cerebral_aneurysm/detail_cerebral_aneurysms.htm
10022758
intracranial aneurysm AE
HPO: HP_0004944
SIDER: C0007766
a thrombosis AE that is a rare lesion and may be defined as a thrombosis of a vessel without any obvious underlying cause that occurs in the aorta
SS
WEB: http://circ.ahajournals.org/content/17/5/941.full.pdf
10002910
aortic thrombosis AE
an arterial thrombosis AE that is characterized by the occurrence of a thrombus in the carotid arteries (two large blood vessels that supply oxygenated blood to the large, front part of the brain)
SS
WEB: http://www.webmd.com/heart-disease/carotid-artery-disease-causes-symptoms-tests-and-treatment
10007688
carotid artery thrombosis AE
an arterial embolism AE that occurs in the cerebral artery
SS
cerebral embolism AE
embolic stroke AE
thrombotic stroke AE
WEB: http://medical-dictionary.thefreedictionary.com/cerebral+embolism
10008088
10014498
10043647
cerebral artery embolism AE
an arterial thrombosis AE that occurs in the cerebral artery, also referred to as an embolism AE
[SS] Per DRA and KKB's comment, this term may also be characterized as a type of embolism even though labeled thrombosis.
cerebral thrombosis AE
10008092
10008132
cerebral artery thrombosis AE
a venous thrombosis AE that is characterized by thrombosis of the venous channels in the brain. It is an uncommon cause of cerebral infarction relative to arterial disease, but it is an important consideration because of its potential morbidity.
[SS] From http://medical-dictionary.thefreedictionary.com/cerebral+venous+thrombosis, Merwarth syndrome - progressive hemiplegia due to venous occlusion. Synonym(s): cerebral venous thrombosis
SS
WEB: http://emedicine.medscape.com/article/1162804-overview
10008138
cerebral venous thrombosis AE
a venous thrombosis AE that occurs when a blood clot forms in the brain’s venous sinuses that prevents blood from draining out of the brain. As a result, blood cells may break and leak blood into the brain tissues, forming a hemorrhage.
SS
CVST
WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/cerebral_venous_sinus_thrombosis_134,69/
10061251
intracranial venous sinus thrombosis AE
an embolism AE that is caused by a gas bubble that enters the vein
[SS] The term 'gas embolism' is listed as a unique term, and not a superset or a synonym of 'air embolism' due to the different pathology reconized by physicians that air embolism is mostly recognized when an air bubble caused by IV or other injection device enters the vein, while a gas embolism is mostly caused by a gas bubble released as a product of an infection, or other devices such as nitrogen tank.
SS
gas embolilsm AE
a thrombosis that is characterized by a clot that blocks blood flow a mesenteric vein, one of two veins through which blood leaves the intestine. The condition interrupts the blood supply to the intestine and can result in damage to the intestines.
[SS] http://emedicine.medscape.com/article/193921-overview, Mesenteric venous thrombosis (also known as visceral venous thrombosis) is a rare but lethal form of mesenteric ischemia (see the image below). Antonio Hodgson first described mesenteric ischemia in the latter part of the 15th century. In 1895, Elliot first described mesenteric venous thrombosis as a cause of mesenteric ischemia. By the turn of the 19th century, many review articles and texts were describing the recent advances in the characterization and treatment of mesenteric ischemia, particularly venous thrombosis. In 1935, Warren and Eberhard reported that intestinal infarction resulted from ischemia due to venous thrombosis, and they reported a mortality rate of 34% in patients with venous thrombosis after resection. Unfortunately, despite improvements in therapy, this mortality rate still holds.
SS
mesenteric venous thrombosis AE
visceral venous thrombosis AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001157.htm
10027402
mesenteric vein thrombosis AE
a thrombosis AE that is an uncommon condition induced by thrombotic or nonthrombotic obstruction of hepatic venous outflow and characterized by hepatomegaly, ascites, and abdominal pain.
SS
WEB: http://emedicine.medscape.com/article/184430-overview
10006537
Budd-Chiari syndrome AE
a thrombosis AE that occurs in the vein carrying the blood away from the retina
[SS] The term 'retinal vein thrombosis' is listed as a different class from 'retinal vein occlusion' for the difference in the pathological process of how the blockage occurs in the vein.
SS
10038908
retinal vein thrombosis AE
an adverse event causity that represents a predictive causal relation between an adverse event and a medical intervention. Specifically, it addresses this question: will the next person who received a medical intervention will develop the adverse event? Or: how frequently will vaccine recipients experience the adverse event as a result of a medical intervention?
YH
predictive causality of adverse event
Stratton KR, Howe CJ, Johnson RB. 1994. Adverse events associated with childhood vaccines: Evidence bearing on causality. National Academy Press. Washing, D.C. Page 20.
predictive AE causality
an embolism AE that occurs in the artery. It is a sudden interruption of blood flow to an organ or body part due to a clot (embolus).
SS
embolism arterial AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001102.htm
10014513
arterial embolism AE
a thrombosis AE* that is a result of when a blood vessel is obstructed by a blood clot (embolus) that has been carried in the bloodstream from the site of its formation. Thromboembolic disease includes both venous thromboembolism (VTE) and arterial thrombosis. VTE is an general term which refers to mainly two conditions: deep vein thrombosis (DVT) and its potentially fatal acute complication, pulmonary embolism (PE). Arterial embolism is a frequent complication in patients with atrial fibrillation (AF) and can lead to stroke or systemic embolism.
* see editor note
[SS] Per DRA and KKB's comment, this term is synonymous to venous thrombosis even though labeled embolism. Cross-reference is made via seeAlso.
SS
VTE
embolism venous AE
venous thromboembolism AE
WEB: http://www.boehringer-ingelheim.com/products/prescription_medicines/thromboembolic_diseases.html
10014522
venous embolism AE
OAE: 0001505
an embolism AE that is characterized by the obstruction of blood vessel by fat droplets
SS
WEB: http://emedicine.medscape.com/article/460524-overview#showall
10016246
fat embolism AE
a embolism AE that is infected with bacteria containing pus
SS
septic embolism AE
WEB: http://www.medicalnewstoday.com/articles/153704.php
10040067
septic embolus AE
a thrombosis AE that occurs in or may be caused by an implanted device in the body
SS
10062546
thrombosis in device AE
a thrombosis AE that is characterized by a pathological process involving thrombocytopenia, microangiopathic haemolytic anaemia and microvascular occlusion
SS
TMA
WEB: http://www.ncbi.nlm.nih.gov/pubmed/22802583
10043645
This term is obsolete since there is another term with the same name already. Oliver
obsolete: thrombotic microangiopathy AE
an arterial thrombosis AE that occurs in the limb(s) of the body
SS
10003180
arterial thrombosis limb AE
an inflammation AE that occurs in eye.
YH, JX
eye inflammation AE
SS
10022104
injection site thrombosis AE
a deep vein thrombosis AE that occurs in the pelvis. Ovarian vein thrombosis arises out of the coincident conditions of venous stasis and hypercoagulability, which are commonly present in the recently postpartum patient.
SS
ovarian vein thrombosis AE
WEB: http://emedicine.medscape.com/article/404364-overview
10034272
pelvic venous thrombosis AE
an embolism AE that is charaterized by a sudden blockage in a lung artery. The blockage usually is caused by a blood clot that travels to the lung from a vein in the leg.
SS
PE
WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/pe/
10061340
peripheral embolism AE
a thrombosis AE that occurs in subclavian vein. Among patients with effort-induced thrombosis with subclavian vein stenosis, the thrombosis occurs in the dominant arm in 80% of cases.
SS
WEB: http://emedicine.medscape.com/article/424777-overview#showall
10049446
subclavian vein thrombosis AE
a thrombophlebitis AE that is characterized by an inflammation of a vein due to a blood clot in a vein located just below the skin's surface.
YH: MedDRA: 10043595 is for "thrombophlebitis superficial"; MedDRA: 10042554 is for "superficial thrombophlebitis"
SS, YH, MW
thrombophlebitis superficial AE
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000199.htm
表在性血栓性静脈炎
superficial thrombophlebitis AE
CTCAE: E13817
NCIt: C78634
UMLS CUI: C1510431
SS
10061408
venous thrombosis limb AE
a thrombosis that is characterized by a blockage of the small veins that carry blood away from the retina. The retina is the layer of tissue at the back of the inner eye that converts light images to nerve signals and sends them to the brain.
SS
RVO
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007330.htm
10038907
retinal vein occlusion AE
a thrombosis AE that occurs in the atrium (left or right)
SS
WEB: http://ehjcimaging.oxfordjournals.org/content/9/1/204.full
10048632
atrial thrombosis AE
an arterial embolism AE that occurs in the coronary artery
SS
coronary artery thrombosis AE
coronary embolism AE
WEB: http://medical-dictionary.thefreedictionary.com/Coronary+embolism
10011084
10011091
coronary artery embolism AE
a sleep apnea AE is a sleep disorder AE in which breathing repeatedly stops and starts. Basically, it is a crossproduct of sleep disorder AE and apnea AE.
MW, YH
WEB: http://www.mayoclinic.org/diseases-conditions/sleep-apnea/basics/definition/con-20020286
10040975
sleep apnea AE
CTCAE: E13566
NCIt: C26884
a brain AE that occurs when flow of oxygen-rich blood to a portion of the brain is blocked
JX, LW, YH
cardiovascular accident AE
WEB: http://en.wikipedia.org/wiki/Stroke
WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/stroke/
中风
10042244
stroke AE
CTCAE: E12826
NCIt: C3390
a stroke AE that occurs when a blood vessel that supplies the brain becomes blocked or "clogged" and impairs blood flow to part of the brain.
SS
ischaemic stroke AE
WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
10061256
ischemic stroke AE
a stroke AE that occurs when a blood vessel that supplies the brain ruptures and bleeds causing the deficiency of oxygen and nutrients to brain cells and tissues
SS
haemorrhagic stroke AE
WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
10019016
hemorrhagic stroke AE
a haemorrhagic stroke AE that is cuased by hypertension (high blood pressure), and bleeding occurs suddenly and rapidly.
SS
intracerebral haemorrhagic stroke AE
WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
intracerebral hemorrhagic stroke AE
a haemorrhagic stroke AE that is cuased by the bleeding (haemorrhage) between the brain and the meninges (the membrane that covers the brain) in the subarachnoid space.
SS
subarachnoid haemorrhagic stroke AE
WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
subarachnoid hemorrhagic stroke AE
an ischaemic stroke AE that is caused by a thrombus (blood clot) that develops in the arteries supplying blood to the brain
SS
WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
10043647
thrombotic stroke AE
an ischaemic stroke AE that is caused by an embolus (a blood clot that formms elsewhere in the body and travels through the bloodstream to the brain).
SS
WEB: http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/types_of_stroke_85,P00813/
10014498
embolic stroke AE
a behavior and neurological AE that has an outcome of a mental illness or psychiatiric disorder. The mental illness is a mental or behavioral pattern or anomaly that causes either suffering or an impaired ability to function in ordinary life (disability), and which is not developmentally or socially normative.
YH, Izabela Birsanescu
mental disorder AE
WEB: http://en.wikipedia.org/wiki/Mental_disorder
10037175
psychiatric disorder AE
a psychiatric disorder AE that has an outcome of a adjustment disorder. An adjustment disorder is an unexpectedly strong emotional or behavioral reaction that occurs in response to an identifiable stressful life event or life change that occurred within the previous three months.
Yongqun He, Izabela Birsanescu
WEB: http://www.healthline.com/health/adjustment-disorder
10001301
10001302
adjustment disorder AE
an adjustment disorder AE that has an additional depressed mood. The person is more depressed than would be expected after a stressful event.
Yongqun He, Izabela Birsanescu
WEB: http://www.summitmedicalgroup.com/library/adult_health/bha_adjustment_disorder_with_depressed_mood/
10001297
adjustment disorder with depressed mood AE
a hemorrhage AE that has an outcome of bleeding from anastomosis site. Anastomosis: pathological formation of an opening between two normally distinct spaces or organs.
Yongqun He, Izabela Birsanescu
WEB: http://medical-dictionary.thefreedictionary.com/anastomosis
10071781
anastomotic bleeding AE
a clostridial infection AE that is caused by C. difficule.
Yongqun He, Izabela Birsanescu
WEB: http://www.mayoclinic.org/diseases-conditions/c-difficile/basics/definition/CON-20029664?p=1
10054236
Clostridium difficile infection AE
Yongqun He, Izabela Birsanescu
a bacteraemia AE that is more specifically associated with a Gram-negative bacterium.
10054228
Gram-negative bacteremia AE
a physical quality that a drug level inside a host increases
Yongqun He, Izabela Birsanescu
drug level increase
a quality that represents the level of critical or lethal reaction to an erroneous dosage of a drug medication.
Yognqun He, Izabela Birsanescu
WEB: http://medical-dictionary.thefreedictionary.com/drug+toxicity
Drug toxicity may occur due to human error or intentional overdose in the case of suicide or homicide.
drug toxicity
a hemorrhage AE that has an outcome of massive amounts of blood loss. A typical Intraoperative hemorrhage has a blood loss exceeding 1000 mL or requires a blood transfusion
Yongqun He, Izabela Birsanescu
WEB: http://www.uptodate.com/contents/management-of-hemorrhage-in-gynecologic-surgery
10055298
Intraoperative hemorrhage AE
CTCAE: E11810
NCIt: C35135
an abscess AE that shows a cavity of pus within the pancreas
Yongqun He, Izabela Birsanescu
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000270.htm
10048984
pancreatic abscess AE
a sugery AE that has an adverse outcome where the recipient’s body rejects the pancreas transplantation.
Yongqun He, Izabela Birsanescu
WEB: http://www.medscape.com/viewarticle/436542_13
10049169
pancreas transplant rejection AE
an infection AE that has an outcome of a severe local inflammation, usually with pus formation, generally caused by one of the pyogenic bacteria.
Yongqun He, Izabela Birsanescu
WEB: http://www.medilexicon.com/medicaldictionary.php?t=44396
10021861
pyogenic infection AE
a fever AE that has unknown origin.
Yongqun He, Izabela Birsanescu
WEB: http://medicine.academic.ru/123590/fever_of_unknown_origin
10016563
fever of unknown origin AE
a temporal interval that starts at the time a medical intervention occurs and ends at the time when the initial bodily process occurs.
Yongqun He
time interval for initial process after medical intervention
a temporal interval that starts at the time in the end of the initial process and ends at the time when the final process leading to an adverse event clinical outcome occurs.
Yongqun He
time interval for intermediate causal AE process
a temporal interval that covers the time period of the final process leading to the display of clinical outcome.
Yongqun He
time interval for AE process showing clinical outcome
a pathological bodily process that starts to occur after a medical intervention.
Yongqun He
initial stage causal AE sub-process
a pathological bodily process that occurs in the middle of the causal adverse event process, i.e., after the initial causal AE process and before the last AE process that results in the adverse outcome.
Yongqun He
intermediate stage causal AE sub-process
a pathological bodily process that occurs in the last stage of adverse event and results in the adverse clinical outcome. This clinical outcome may come as a result of causal adverse event (caused by the medical intervention), or result from an unrelevant cause (i.e., not the designated medical intervention).
Yongqun He
AE process showing pathological clinical outcome
late stage AE formation sub-process
a temporal interval that starts at the time a medical intervention occurs and ends at the time an adverse event ends. The adverse event ends when the patient recovers from the adverse event or dies due to the severity of the adverse event.
Yongqun He
adverse event time period
an organism that has the role of 'patient role'.
Yongqun He
patient
an adverse event tme period whent the adverse event is causal adverse event.
Yongqun He
time interval for causal AE
a causality of AE based on the Naranjo ADR probability scale method.
SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
Yongqun He
Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
WEB: http://livertox.nih.gov/Narajo.html
causality based on Naranjo ADR probability scale
a Naranjo ADR probability scale that shows definite causality result. It happens when the score is >=9.
SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
Yongqun He
Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
WEB: http://livertox.nih.gov/Narajo.html
Definite Naranjo ADR probability
a Naranjo ADR probability scale that shows probable causality result. It happens when the score is 5-8.
SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
Yongqun He
Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
WEB: http://livertox.nih.gov/Narajo.html
Probably Naranjo ADR probability
a Naranjo ADR probability scale that shows possible causality result. It happens when the score is 1-4.
SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
Yongqun He
Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
WEB: http://livertox.nih.gov/Narajo.html
Possible Naranjo ADR probability
a Naranjo ADR probability scale that shows doubtful causality result. It happens when the score is <=0.
SCORING: ≥9 = definite; 5–8 = probable; 1–4 = possible; ≤0 = doubtful
Yongqun He
Naranjo CA, Busto U, Sellers EM et al. (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239–45. doi:10.1038/clpt.1981.154. PMID 7249508.
WEB: http://livertox.nih.gov/Narajo.html
Doubtful Naranjo ADR probability
a causality of AE that is based on the Clinical Data Interchange Consortium (CDISC) system
Yongqun He
causality based on the Clinical Data Interchange Consortium (CDISC) system
Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf
AE causality based on CDISC system
an AE causality based on CDISC system that has the scale "Not Related".
Yongqun He
Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf
Not Related AE causality based on CDISC system
an AE causality based on CDISC system that has the scale "Possibly Related".
Yongqun He
Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf
Possibly Related AE causality based on CDISC system
an AE causality based on CDISC system that has the scale "Unlikely Related".
Yongqun He
Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
WEB: http://www.cdisc.org/stuff/contentmgr/files/0/3fa5f30f40ce5ecc7b3f91e558b55f73/misc/study_data_tabulation_model_v1_4.pdf
Unlikely Related AE causality based on CDISC system
an AE causality based on CDISC system that has the scale "Definitely Related".
Yongqun He
Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
WEB: http://www.cdisc.org/stuff/contentmgr/files/0/5aee16f59e8d6bd2083dbb5c1639f224/misc/adam_ae_final_v1.pdf
Definitely Related AE causality based on CDISC system
an AE causality based on CDISC system that has the scale "Probably Related".
Yongqun He
Burnstead B, Furlan G. Unifying drug safety and clinical databases. Curr Drug Saf. 2013 Feb;8(1):56-62. PMID: 23656448.
WEB: http://www.cdisc.org/stuff/contentmgr/files/0/5aee16f59e8d6bd2083dbb5c1639f224/misc/adam_ae_final_v1.pdf
Probably Related AE causality based on CDISC system
an AE causality that is based on the Drug Interaction Probability Scale (DIPS).
Score:
Highly Probable: >8
Probable: 5–8
Possible: 2–4
Doubtful: <2
Yongqun He
Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.
causality based on DIPS score
a causality based on DIPS score that is "Highly Probable". It occurs when the sore is >8.
Score:
Highly Probable: >8
Probable: 5–8
Possible: 2–4
Doubtful: <2
Yongqun He
Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.
Highly Probable causality based on DIPS score
a causality based on DIPS score that is "Probable". It occurs when the sore is 5-8.
Score:
Highly Probable: >8
Probable: 5–8
Possible: 2–4
Doubtful: <2
Yongqun He
Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.
Probable causality based on DIPS score
a causality based on DIPS score that is "Possible". It occurs when the sore is 2-4.
Score:
Highly Probable: >8
Probable: 5–8
Possible: 2–4
Doubtful: <2
Yongqun He
Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.
Possible causality based on DIPS score
a causality based on DIPS score that is "Doubtful". It occurs when the sore is <2.
Score:
Highly Probable: >8
Probable: 5–8
Possible: 2–4
Doubtful: <2
Yongqun He
Horn JR, Hansten PD, Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007 Apr;41(4):674-80. PMID: 17389673.
Doubtful causality based on DIPS score
a severity of AE that shows sign and symptom within normal limits.
YH, SS
AE severity Grade 0
Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_0_Adverse_Event
Note the AE severity Grade 0 equals to CTCAE G0 AE severity.
AE severity G0
CTCAE4: E10004 (Grade 0 Adverse Event)
a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated.
YH, SS
AE severity Grade 1
Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_1_Adverse_Event
Note the AE severity Grade 1 equals to CTCAE G1 AE severity.
AE severity G1
CTCAE4: E10005 (Grade 1 Adverse Event)
a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances).
YH, SS
AE severity Grade 2
Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_2_Adverse_Event
Note the AE severity Grade 2 equals to CTCAE G2 AE severity.
AE severity G2
CTCAE4: E10006 (Grade 2 Adverse Event)
a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet).
YH, SS
AE severity Grade 3
Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_3_Adverse_Event
Note the AE severity Grade 3 equals to CTCAE G3 AE severity.
AE severity G3
CTCAE4: E10007 (Grade 3 Adverse Event)
a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral).
YH, SS
AE severity Grade 4
Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_4_Adverse_Event
Note the AE severity Grade 4 equals to CTCAE G4 AE severity.
AE severity G4
CTCAE4: E10008 (Grade 4 Adverse Event)
a severity of AE that results in death.
YH, SS
AE severity Grade 5
Web: http://ncicb.nci.nih.gov/xml/owl/EVS/ctcae.owl#Grade_5_Adverse_Event
Note the AE severity Grade 5 equals to CTCAE G5 AE severity.
AE severity G5
CTCAE4: E10009 (Grade 5 Adverse Event)
a blood phosphate abnormal AE that has an abnormally increased amount of phosphate in the blood
EB, YH, MW
WEB: https://en.wikipedia.org/wiki/Hyperphosphatemia
10020712
hyperphosphatemia AE
HPO: HP_0002905
a clincal laboratory test that performs a medical examination using X-ray, a type of electromagnetic radiation.
Rebecca Racz, Yongqun He
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003337.htm
X-ray clinical test
a respiratory distress AE that has an outcome of insufficient oxygen flow in the heart and respiratory system.
SS, YH
WEB: http://medicalcenter.osu.edu/patientcare/healthcare_services/lung_diseases/about/signs/Pages/index.aspx, http://www.merriam-webster.com/dictionary/cardiorespiratory
10049874
cardio-respiratory distress AE
A joint disorder AE that has the presence of increased intra-articular fluid. It can be caused by trauma, arthritis, or gout and often affects the knee.
RR, YH, MW
PMID: 19915432
WEB: http://en.wikipedia.org/wiki/Joint_effusion
10023215
joint effusion AE
CTCAE:E12431
NCIt:C49052
a gastrointestinal disorder AE that shows a problem with the stomach, ranging from indigestion and heartburn to peptic ulcers and GERD.
RR, YH
stomach disorder AE
WEB: http://www.nlm.nih.gov/medlineplus/stomachdisorders.html
10056819
gastric disorder AE
A medical intervention that involves the replacement of bodily fluids excessively lost. Fluids may be replaced orally or intravenously.
RR, YH
fluid resuscitation
WEB: http://www.mayoclinic.org/diseases-conditions/dehydration/basics/treatment/con-20030056
10061858
fluid replacement
An inflammation AE that displays an inflammation (not an infection) of the thyroid gland.
http://www.endocrineweb.com/conditions/thyroid/thyroiditis
yongqun he, liwei wang
thyroiditis AE
a urinary system AE that has an outcome of the excretion of glucose into the urine.
web: http://en.wikipedia.org/wiki/glycosuria
LW, YH
glucosuria AE
an inflammation AE that shows localized nodular inflammation found in tissues.
KM, JX, YH
WEB: http://en.wikipedia.org/wiki/Granuloma
WEB: http://www.mayoclinic.org/granuloma/expert-answers/faq-20057838
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=3629
10018691
granuloma AE
a burning sensation AE that occurs at the skin.
KM, JX, YH
10054786
skin burning sensation AE
a sensory capability AE that has an outcome of numbness, a loss of sensation of feeling in a part of the body.
YH, JS
WEB: http://www.mayoclinic.org/symptoms/numbness/basics/definition/sym-20050938
10029829
numbness AE
a pneumonia AE that occurs at the interstitial lung. Interstitial pneumonia is often caused by an infection of bacteria, viruses, or fungii. A bacterium called Mycoplasma pneumonia is the most common cause.
JX, YH
WEB: http://www.webmd.com/lung/interstitial-lung-disease
10022617
interstitial pneumonia AE
a numbness AE that occurs around the mouth.
The terms 'circumoral numbness AE' and 'circumoral paresthesia AE' appear to be synonyms.
YH, JS
WEB: http://link.springer.com/referenceworkentry/10.1007%2F3-540-29623-9_6515
10049339
circumoral numbness AE
Skin necrosis AE is a necrosis AE that results in the death of the skin tissue. Skin necrosis often occurs when not enough blood and oxygen are supplied to a given skin region.
JX, LW, YH
皮肤坏死
10040893
skin necrosis AE
UMLS ID: C0151799
Systemic lupus erythematosus (SLE) syndrome AE is a lupus syndrome AE that is systemic and disseminated. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. Although “lupus” actually includes a number of different diseases, SLE is the most common type of lupus, and when people say “lupus,” they are often referring to SLE.
JX, LW, YH
SLE
systemic lupus erythematosus syndrome AE
系统性红斑狼疮
WEB: http://en.wikipedia.org/wiki/Systemic_lupus_erythematosus
WEB: http://www.healthline.com/health/systemic-lupus-erythematosus#Overview1
系统性红斑狼疮综合征
systemic lupus erythematosus AE
Urgent urination AE is a urinary system AE that has an outcome of a sudden, compelling urge to urinate, along with discomfort in the bladder.
JX, LW, YH
micturition urgency
urinary urgency
WEB: http://sideeffects.embl.de/se/C0085606/
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003140.htm
尿急
10046593
urgent urination AE
CTCAE: E13062
NCIt: C50792
UMLS CUI: C0439609
Precordialgia AE is a pain AE that pain located in the precordial region.
JX, LW, YH
WEB: http://www.drugs.com/dict/precordialgia.html
心前痛
precordialgia AE
Dyshidrosis AE is a skin AE that shows a disorder of eccrine sweat glands, characterized by small blisters on the hands or feet.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Dyshidrosis
汗疱疹
10013912
dyshidrosis AE
Ankle swelling AE is an edema AE that shows abnormal buildup of fluid in the ankles. Ankle swelling is a sign of fluid buildup or inflammation of the joint and tissues of the ankle. Mild ankle swelling is a common occurrence after standing for a long period.
JX, LW, YH
WEB: http://www.healthgrades.com/symptoms/ankle-swelling
踝部水肿
10002554
ankle swelling AE
UMLS ID: C0235439
Renal dysfunction AE is a kidney AE that has an outcome of reduced capacity to excrete metabolic products which accumulate systemically and are detectable clinicopathologically by renal function tests. The early stage of uremia.
This term appears to be a synonym to the 'renal failure AE'.
JX, LW, YH
hepatic and renal function disorder AE
肾功能障碍
renal dysfunction AE
UMLS ID: C0859242
Epiphora AE is a eye AE that shows an overflow of tears onto the face. In this case, there is insufficient tear film drainage from the eyes, and the tears will drain down the face rather than through the nasolacrimal system.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Epiphora_(medicine)
泪溢
10015068
epiphora AE
UMLS ID: C0152227
Hemolytic anemia AE is an anemia AE associated with hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular). Such an AE can be relatively harmless or life-threatening.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Hemolytic_anemia
溶血性贫血
10019493
hemolytic anemia AE
a behavioral and neurological AE where somniloquy also is called sleep-talking, a parasomnia that refers to talking aloud while asleep. Somniloquy can be quite loud, ranging from simple mumbling sounds to loud shouts and long frequently inarticulate speeches, and can occur many times during a sleep cycle. As with sleepwalking and night terrors, sleeptalking usually occurs during the less-deep delta-wave NREM sleep stages or during temporary arousals therefrom.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Somniloquy
梦呓
somniloquy AE
Cholelithiasis AE is a liver, biliary, and pancreatic AE that shows hard deposits forming inside the gallbladder. Gallstones may be as small as a grain of sand or as large as a golf ball.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Gallstone
10008629
cholelithiasis AE
UMLS ID: C1328486
Blepharoptosis AE is an eye AE that shows droopy upper eyelid or ptosis that presents with substantial blockage upper part of field of vision, risk of amblyopia among young children, and dramatic change in the facial appearance.
JX, LW, YH
WEB: http://eyewiki.aao.org/Blepharoptosis
眼睑下垂
10005157
blepharoptosis AE
A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to, at which point AE symptoms begin to arise. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses.
AG, YH
OBI
AE associated dose range
A healing process that leads to an outcome with improved relative health from an adverse event
AG, YH
NCI Thesaurus
AE recovery
an AE recovery rate that represents a rate of adverse event recovery
AG, YH
AE recovery rate
An AE recovery that is sepcifically for recovery from a chemotherapy drug adverse event.
AG, YH
chemotherapy drug AE recovery
AG, YH
complete AE recovery
an information content entity that represents an extent of recovery from an adverse event
AG, YH
extent of AE recovery
an extent of AE recovery that has an outcome of incomplete recovery
AG, YH
incomplete AE recovery
an epileptic seizure AE that is characterized by tonic-clonic seizures, involving two phases -- the tonic phase in which the body becomes rigid, and clonic phase in which there is uncontrolled jerking.
JX, LW, YH
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=32957
癫痫大发作
10018658
grand mal AE
Erythema simplex AE is an erythema AE that accompany with blushing or redness of the skin caused by a toxic reaction or a neurovascular phenomenon.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/erythema+simplex
单纯性红斑
erythema simplex AE
Pelvic pain AE is a pain AE that occurs in the lower abdomen area. The pain might be steady, or it might come and go. If the pain is severe, it might get in the way of people's daily activities.
JX, LW, YH, MW
WEB: http://www.nlm.nih.gov/medlineplus/pelvicpain.html
骨盆痛
10034263
pelvic pain AE
CTCAE:E13167
NCIt:C40122
Extrasystoles AE is an arrhythmia AE that shows a premature contraction of the heart that is independent of the normal rhythm of the heart and arises in response to an impulse in some part of the heart other than the normal impulse from the sinoatrial node. The extrasystole is followed by a pause, as the heart electrical system "resets" itself and the contraction following the pause is usually more forceful than normal.
JX, LW, YH
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=32159
早搏(额外收缩)
10015856
extrasystoles AE
An increased upper airway secretion AE is a respiratory system AE characterized by an increased secretion at the upper airway location.
RR, YH
10062717
increased upper airway secretion AE
Feeling of body temperature change AE is a feeling abnormal AE that a patient feels a change in body temperature.
RR, YH
10061458
feeling of body temperature change AE
Heartburn AE is a gastric disorder AE that also known as pyrosis, cardialgia, or acid indigestion. It's a burning sensation in the chest, just behind the breastbone or in the epigastrium, the upper central abdomen. The pain often rises in the chest and may radiate to the neck, throat, or angle of the jaw.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Heartburn
胃灼热(烧心)
10019326
heartburn AE
Tonsillitis AE is an inflammation AE that is inflammation of the tonsils most commonly caused by viral or bacterial infection. Symptoms may include sore throat and fever.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Tonsillitis
扁桃体炎
10044008
tonsillitis AE
Non-insulin-dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 2, it's characterized by hyperglycemia (high blood sugar) in the context of insulin resistance and relative lack of insulin.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2
非胰岛素依赖型糖尿病
10029505
non-insulin-dependent diabetes mellitus AE
Insulin dependent diabetes mellitus AE is a diabetes mellitus AE which is also called diabetes mellitus type 1. It results from the autoimmune destruction of the insulin-producing beta cells in the pancreas.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Diabetes_mellitus_type_1
胰岛素依赖型糖尿病
10022497
insulin dependent diabetes mellitus AE
a hyporeflexia AE where the patient shows no sign of reflexes.
JX, LW, YH
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423
反射消失
10003084
areflexia AE
Mastauxea AE is a reproductive system AE that shows enlargement of the breast.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/mastauxe
乳房增大
mastauxe AE
Uveitis AE is an inflammation AE that is inflammation of the uvea, which lines the inside of the eye behind the cornea.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Uveitis
色素层炎
10046851
uveitis AE
CTCAE: E10442
NCIt: C26909
Sexual dysfunctions AE is a reproductive system AE that is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm.
JX, LW, YH
sexual malfunction AE
WEB: http://en.wikipedia.org/wiki/Sexual_dysfunction
性功能障碍
10040477
sexual dysfunctions AE
Hypomnesia AE is a behavior and neurological AE that is an archaic term applied to poor memory, the impaired ability to recall information previously memorized.
JX, LW, YH
WEB: http://psychology.wikia.com/wiki/Hypomnesia
记忆减退
10021035
hypomnesia AE
Phobia AE is a behavior and neurological AE that is a type of anxiety disorder, usually defined as a persistent fear of an object or situation in which the sufferer commits to great lengths in avoiding, typically disproportional to the actual danger posed, often being recognized as irrational.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Phobia
恐惧症
10034912
phobia AE
Lymphadenectasis AE is an edema AE that shows enlargement of the lymph node.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/lymphadenectasis
淋巴结肿大
10025282
lymphadenectasis AE
Asterixis AE is a tremor AE that also called the flapping tremor, or liver flap, which is a tremor of the hand when the wrist is extended, sometimes said to resemble a bird flapping its wings. This motor disorder is characterized by an inability to actively maintain a position, which is demonstrated by jerking movements of the outstretched hands when bent upward at the wrist. The tremor is caused by abnormal function of the diencephalic motor centers in the brain, which regulate the muscles involved in maintaining position.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Asterixis
扑翼样震颤
10003547
asterixis AE
Parageusia AE is a gustatory system AE which is the medical term for a bad taste in the mouth. One common form of parageusia is a metallic taste of food. This can be a side effect of several medications, such as acetazolamide, eszopiclone, zopiclone, metronidazole, or etoposide. Metallic taste is also a type of dysgeusia which is frequently associated with infections in the mouth or upper airways.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Parageusia
味觉颠倒
10033793
parageusia AE
Brain damage AE is a brain AE that also called brain injury is the destruction or degeneration of brain cells. In general, brain damage refers to significant, undiscriminating trauma-induced damage.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Brain_damage
脑损伤
10056389
brain damage AE
Frequent bowel movements AE is a abnormal stool AE that people are having more bowel movements than is normal for them. Often, frequent bowel movements are accompanied by diarrhea, the passage of loosely formed stool.
JX, LW, YH
WEB: http://www.healthgrades.com/symptoms/frequent-bowel-movements
大便频繁
10017367
frequent bowel movements AE
Hyperprolactinemia AE is an endocrine investigation result abnormal AE that is the presence of abnormally high levels of prolactin in the blood. Normal levels are less than 500 mIU/L [20 ng/mL or µg/L] for women, and less than 450 mIU/L for men.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Hyperprolactinaemia
高泌乳素血症
10020739
hyperprolactinemia AE
Galactorrhea AE is a reproductive system AE that is the spontaneous flow of milk from the breast, unassociated with childbirth or nursing.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Galactorrhea
乳溢
10017592
galactorrhea AE
Sitophobia AE is a behavior and neurological AE that shows a morbid or insane dread of eating.
JX, LW, YH
WEB: http://en.wiktionary.org/wiki/sitophobia
畏食
sitophobia AE
Ejection murmur AE is a cardiac disorder AE which is due to turbulent forward flow across the right and left ventricular outflow tract, aortic or pulmonary valve, or through the aorta or pulmonary artery.
JX, LW, YH
WEB: http://www.cardiologysite.com/auscultation/html/ejection_murmurs.html
收缩期喷射性杂音
ejection murmur AE
Hypoactive sexual desire disorder AE is a libido disorder AE that is considered a sexual dysfunction and is characterized as a lack or absence of sexual fantasies and desire for sexual activity, as judged by a clinician.
JX, LW, YH
hyposexuality AE
WEB: http://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder
性欲减退
10020933
hypoactive sexual desire disorder AE
Bigotry AE is a behavior and neurological AE that is a state of mind where a person strongly and unfairly dislikes other people, ideas, etc.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Bigotry
偏执
bigotry AE
Somnambulisma AE is a behavior and neurological AE that also known as sleepwalking or noctambulism, which is a sleep disorder belonging to the parasomnia family. It arise from the slow wave sleep stage in a state of low consciousness and perform activities that are usually performed during a state of full consciousness. These activities can be as benign as sitting up in bed, walking to the bathroom, and cleaning, or as hazardous as cooking, driving, violent gestures, grabbing at hallucinated objects, or even homicide.
JX, LW, YH
noctambulism AE
sleepwalking AE
WEB: http://en.wikipedia.org/wiki/Sleepwalking
梦游症
10041347
somnambulism AE
Hyperphagia AE is an eating disorder AE that also called polyphagia. It's a medical sign meaning excessive hunger and abnormally large intake of solids by mouth. It can be caused by disorders such as diabetes, Kleine–Levin syndrome (a malfunction in the hypothalamus), the genetic disorders Prader–Willi syndrome, and Bardet–Biedl syndrome.
JX, LW, YH
polyphagia AE
食欲过盛
WEB: http://en.wikipedia.org/wiki/Polyphagia
10020710
hyperphagia AE
Corneal pigmentation is a eye AE shows that the melanin is in the superficial stroma and the basal layer of the corneal epithelium.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/corneal+pigmentation
角膜色素沉着
10011040
corneal pigmentation AE
Chromatos AE is a skin AE shows that deposit of pigment in a normally unpigmented area or excessive pigmentation in a normally pigmented site.
JX, LW, YH
WEB: http://www.merriam-webster.com/medical/chromatosis
色素沉着
chromatosis AE
Subclavian steal syndrome AE is an ischaemia AE that is a constellation of signs and symptoms that arise from retrograde (reversed) flow of blood in the vertebral artery or the internal thoracic artery, due to a proximal stenosis (narrowing) and/or occlusion of the subclavian artery. The arm may be supplied by blood flowing in a retrograde direction down the vertebral artery at the expense of the vertebrobasilar circulation. This is called the subclavian steal.
JX, LW, YH
subclavian steal phenomenon AE
subclavian steal steno-occlusive disease AE
锁骨下动脉盗血综合征
10042335
subclavian steal syndrome AE
Allergic rhinitis AE is a rhinitis AE that is an allergic inflammation of the nasal airways. It occurs when an allergen, such as pollen, dust, or animal dander (particles of shed skin and hair) is inhaled by an individual with a sensitized immune system.
JX, LW, YH, MW
WEB: http://en.wikipedia.org/wiki/Allergic_rhinitis
过敏性鼻炎
10001723
allergic rhinitis AE
CTCAE:E13303
NCIt:C79532
Ventricular ectopic beats AE is a cardiac ventricular disorder AE that is a disturbance of the cardiac rhythm frequently related to the electrical conduction system of the heart, in which beats arise from fiber or group of fibers outside the region in the heart muscle ordinarily responsible for impulse formation.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Ectopic_beat
心室异位搏动
10058291
ventricular ectopic beats AE
Sjogren syndrome AE is a eye AE that is a chronic autoimmune disease in which the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands, that produce saliva and tears, respectively.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Sj%C3%B6gren's_syndrome
干燥综合症
10040767
sjogren syndrome AE
Nocturia AE is a urine abnormality AE that is defined by the International Continence Society as “the complaint that the individual has to wake at night one or more times for voiding”.
JX, LW, YH
nycturia AE
WEB: http://en.wikipedia.org/wiki/Nocturia
夜尿症
10029446
nocturia AE
Night sweat is a sweating AE that is the occurrence of excessive sweating (hyperhidrosis and focal hyperhidrosis) during sleep. The sufferer may or may not also suffer from excessive perspiration while awake.
JX, LW, YH
sleep hyperhidrosis AE
WEB: http://en.wikipedia.org/wiki/Night_sweats
夜汗
10029409
night sweat AE
Increased appetite AE is a gustatory system AE that is when people want to eat much more often or in larger quantities than their body requires.
JX, LW, YH
WEB: http://www.healthline.com/symptom/increased-appetite
食欲增加
10021654
increased appetite AE
Vascular dilatation headache AE is a headache AE that shows headache which caused by vascular dilatation.
JX, LW, YH
WEB: http://www.headaches.org/education/Headache_Topic_Sheets/Vascular_Headaches
血管扩张性头痛
vascular dilatation headache AE
Bundle-branch block AE is a conduction system disorder AE that refers to a defect of the heart's electrical conduction system.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Bundle_branch_block
束支传导阻滞
10006578
bundle-branch block AE
Unstable diabetes AE is a diabetes mellitus AE that is a type of diabetes when a person's blood glucose level often swings quickly from high to low and from low to high.
JX, LW, YH
brittle diabetes AE
labile diabetes AE
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=7271
不稳定型糖尿病
10006372
unstable diabetes AE
Tendon rupture AE is a tendon disorder AE shows a tearing of the tendon that occurs when the forces placed upon the tendon exceed its tensile strength.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/Tendon+rupture
肌腱断裂
10043248
tendon rupture AE
Tendovaginitis AE is an inflammation AE that is an acute or chronic inflammation of the tendon sheath, occurring in the region of the hand, the wrist joint, the forearm (radial and ulnar tenobursitis), the foot, the ankle joint, and the Achilles tendon (achillobursitis).
JX, LW, YH
tenovaginitis AE
WEB: http://encyclopedia2.thefreedictionary.com/Tendovaginitis
腱鞘炎
10067216
tendovaginitis AE
Loose stools AE is a abnormal stool AE that is usually a form of diarrhea and many conditions causing loose stool will be listed under diarrhea. It may also be related to watery stool (also within the spectrum of diarrhea).
JX, LW, YH
WEB: http://www.rightdiagnosis.com/sym/loose_stool.htm
稀便
10024840
loose stools AE
Cystitis AE is an inflammation AE that is the medical term for inflammation of the bladder. Most of the time, the inflammation is caused by a bacterial infection, and it's called a urinary tract infection.
JX, LW, YH
WEB: http://www.mayoclinic.org/diseases-conditions/cystitis/basics/definition/con-20024076
膀胱炎
10011781
cystitis AE
Eructation AE is a digestive system AE that is the release of gas from the digestive tract (mainly esophagus and stomach) through the mouth. It is usually accompanied with a typical sound and, at times, an odor.
JX, LW, YH
belching AE
burping AE
ructus AE
WEB: http://en.wikipedia.org/wiki/Burping
嗳气
10015137
eructation AE
Glossolalia AE is a speech disorder AE that is the fluid vocalizing of speech-like syllables that lack any readily comprehended meaning.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Glossolalia
语言不清
glossolalia AE
Leg pain AE is a pain AE that is a common problem in leg, it can be due to a cramp, injury, or other cause.
JX, LW, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003182.htm
腿痛
10024130
leg pain AE
Stomachache AE is a pain AE that the pain in or near your stomach. It is a common symptom associated with transient disorders or serious disease.
JX, LW, YH
abdominal pain AE
stomach pain AE
stomachache AE
WEB: http://en.wikipedia.org/wiki/Abdominal_pain
http://www.nhs.uk/conditions/stomach-ache-abdominal-pain/Pages/Introduction.aspx
胃痛
10042126
stomach ache AE
CTCAE: E10460
NCIt: C26682
Conduction block AE is a conduction system disorder AE that shows failure of impulse transmission at some point along a nerve fiber, although conduction along the segments proximal and distal to it are unaffected.
JX, LW, YH
WEB: http://www.medilexicon.com/medicaldictionary.php?t=10757
传导阻滞
conduction block AE
Photodermatitis AE is a dermatitis AE that referred to as sun poisoning or photoallergy, is a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Photodermatitis
光敏性皮炎
photodermatitis AE
Pygalgia AE is a pain AE that is a rarely used term meaning pain in the buttocks.
JX, LW, YH
WEB: http://www.medilexicon.com/medicaldictionary.php?t=74312
臀痛
pygalgia AE
Throat irritation AE is a discomfort AE that refers to a dry cough, a scratchy feeling at the back of the throat, or a sensation of a lumpy feeling or something stuck at the back of the throat.
JX, LW, YH
throat discomfort AE
WEB: http://en.wikipedia.org/wiki/Throat_irritation
咽喉不适
10043521
throat irritation AE
Interstitial nephritis AE is an inflammation AE that is a form of nephritis affecting the interstitium of the kidneys surrounding the tubules. This disease can be either acute, meaning it occurs suddenly, or chronic, meaning it is ongoing and eventually ends in kidney failure.
JX, LW, YH
tubulointerstitial nephritis AE
WEB: http://en.wikipedia.org/wiki/Interstitial_nephritis
间质肾炎
10048302
interstitial nephritis AE
Hoarseness AE is a hoarseness AE that refers to a difficulty making sounds when trying to speak. Vocal sounds may be weak, breathy, scratchy, or husky, and the pitch or quality of the voice may change.
JX, LW, YH, MW
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003054.htm
声音嘶哑
10020201
hoarseness AE
CTCAE:E13384
NCIt:C47813
Photosensitization AE is a hypersensitivity AE that refers to development of abnormally heightened reactivity of the skin or eyes to sunlight.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/photosensitization
光敏
photosensitization AE
Fanconi syndrome AE is a kidney AE that is a disease of the proximal renal tubules of the kidney in which glucose, amino acids, uric acid, phosphate and bicarbonate are passed into the urine, instead of being reabsorbed.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Fanconi_syndrome
范可尼综合征
10016219
fanconi syndrome AE
Keratoconjunctivitis AE is an inflammation AE that is inflammation of the cornea and conjunctiva. When only the cornea is inflamed, it is called keratitis; when only the conjunctiva is inflamed, it is called conjunctivitis.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Keratoconjunctivitis
角膜结膜炎
10023348
keratoconjunctivitis AE
Hepatic insufficiency AE is a liver disorder AE that shows a failure or partial failure of normal liver function.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/hepatic+insufficiency
肝功能不全
10056542
hepatic insufficiency AE
Hypoxemia AE is a blood gas investigation result abnormal AE that is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Hypoxemia
低血氧症
10021142
hypoxemia AE
Irritant contact dermatitis AE is a dermatitis AE that is a form of contact dermatitis that can be divided into forms caused by chemical irritants and those caused by physical irritants.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Irritant_contact_dermatitis
刺激性接触性皮炎
irritant contact dermatitis AE
Pitting edema AE is an edema AE that shows observable swelling of body tissues due to fluid accumulation that may be demonstrated by applying pressure to the swollen area (such as by depressing the skin with a finger).
JX, LW, YH
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=88528
指压性水肿
10054547
pitting edema AE
Acute bronchitis AE is a bronchitis AE that is an inflammation of the large bronchi (medium-size airways) in the lungs that is usually caused by viruses or bacteria and may last several days or weeks. Characteristic symptoms include cough, sputum (phlegm) production, and shortness of breath and wheezing related to the obstruction of the inflamed airways.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Acute_bronchitis
急性支气管炎
10000687
acute bronchitis AE
Renal calculus AE is a kidney AE that is a solid concretion or crystal aggregation formed in the kidneys from minerals in the urine. Kidney stones typically leave the body by passage in the urine stream, and many stones are formed and passed without causing symptoms. If stones grow to sufficient size (usually at least 3 millimeters (0.12 in)) they can cause blockage of the ureter. This leads to pain, most commonly beginning in the flank or lower back and often radiating to the groin or genitals.
JX, LW, YH
CTCAE: E13018
NCIt: C26807
kidney stone AE
nephrolithiasis AE
renal calculi AE
WEB: http://en.wikipedia.org/wiki/Kidney_stone
肾结石
10038385
10038386
renal calculus AE
Clouding of consciousness AE is a sensory capability AE that is a term used in conventional medicine denoting an abnormality in the "regulation" of the "overall level" of consciousness that is mild and less severe than a delirium. The sufferer experiences a subjective sensation of mental clouding described as feeling "foggy".
JX, LW, YH
brain fog AE
mental fog AE
WEB: http://en.wikipedia.org/wiki/Clouding_of_consciousness
意识模糊
clouding of consciousness AE
Reflex tachycardia AE is a tachycardia AE that shows increased heart rate in response to some stimulus conveyed through the cardiac nerves.
JX, LW, YH
WEB: http://www.medilexicon.com/medicaldictionary.php?t=89526
反射性心动过速
10063096
reflex tachycardia AE
Joint sprain AE is a joint disorder AE that is damage to one or more ligaments in a joint, often caused by trauma or the joint being taken beyond its functional range of motion.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Sprain
关节扭伤
10023229
joint sprain AE
Epicondylitis AE is an inflammation AE that is a type of musculoskeletal disorder that refers to an inflammation of an epicondyle.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Epicondylitis
上髁炎
10014971
epicondylitis AE
Melanoglosia AE is a tongue AE that shows tongue turn black. Any blackening of the tongue associated with certain disorders and diseases in animals and humans.
JX, LW, YH
WEB: http://encyclopedia2.thefreedictionary.com/melanoglosia
舌黑
10014971
melanoglosia AE
Ventricular tachycardia AE is a tachycardia AE that is a type of tachycardia, or a rapid heart beat that arises from improper electrical activity of the heart presenting as a rapid heart rhythm, that starts in the bottom chambers of the heart, called the ventricles.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Ventricular_tachycardia
心室性心搏过速
10047302
ventricular tachycardia AE
CTCAE: E10239
NCIt: C50802
Granulomatous hepatitis AE is a hepatitis AE that refers to an inflammatory liver disease associated with granuloma formation in the liver.
JX, LW, YH
WEB: http://radiopaedia.org/articles/granulomatous-hepatitis
肉芽肿性肝炎
granulomatous hepatitis AE
Hypogeusia AE is a gustatory system AE that is a reduced ability to taste things (to taste sweet, sour, bitter, or salty substances).
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Hypogeusia
味觉减弱
10020989
hypogeusia AE
Dysphoria AE is a behavior and neurological AE that is a profound state of unease or dissatisfaction. In a psychiatric context, dysphoria may accompany depression, anxiety, or agitation. Common reactions to dysphoria include emotional distress or indifference.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Dysphoria
烦躁不安
10013954
dysphoria AE
Oneirism AE is a behavior and neurological AE that is a state of abnormal consciousness in which dream-like experiences and hallucinations happen while awake.
JX, LW, YH
WEB: http://en.wiktionary.org/wiki/oneirism
梦幻症
10030332
oneirism AE
Podalgia AE is a pain AE that shows pain in the foot.
JX, LW, YH
WEB: http://en.wiktionary.org/wiki/podalgia
足痛
podalgia AE
Brachialgia AE is a pain AE that shows pain in the arm.
JX, LW, YH
WEB: http://en.wiktionary.org/wiki/brachialgia
臂痛
10068901
brachialgia AE
Coxalgia AE is a pain AE that shows pain in the hip.
JX, LW, YH
WEB: http://en.wiktionary.org/wiki/coxalgia
髋痛
10011249
coxalgia AE
Limb injury AE is an injury AE which involve damage to bones, joints, ligament, musles, the major blood vessels and nerves of the limb.
JX, LW, YH
肢体伤
10061225
limb injury AE
Polymyalgia rheumatica AE is a muscle pain AE that is a syndrome with pain or stiffness, usually in the neck, shoulders, and hips. The pain can be very sudden, or can occur gradually over a period. It may be caused by an inflammatory condition of blood vessels such as temporal arteritis.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Polymyalgia_rheumatica
风湿性多发性肌痛
10036099
polymyalgia rheumatica AE
Fibromyalgia AE is a muscle pain AE that is characterised by chronic widespread pain and allodynia (a heightened and painful response to pressure). Fibromyalgia symptoms are not restricted to pain, leading to the use of the alternative term fibromyalgia syndrome for the condition. Other symptoms include debilitating fatigue, sleep disturbance, and joint stiffness.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Fibromyalgia
纤维肌痛
10048439
fibromyalgia AE
Hepatic encephalopathy AE is an encephalopathy AE that is the occurrence of confusion, altered level of consciousness, and coma as a result of liver failure. In the advanced stages it is called hepatic coma or coma hepaticum.
JX, LW, YH
portosystemic encephalopathy AE
WEB: http://en.wikipedia.org/wiki/Hepatic_encephalopathy
10019660
hepatic encephalopathy AE
a behavior and neurological AE AE that is an abnormal involuntary movement disorder, one of a group of neurological disorders called dyskinesias.
JX, LW, YH
choreia AE
WEB: http://en.wikipedia.org/wiki/Chorea
舞蹈症
10008748
chorea AE
Nightmare AE is a sleep disorder AE that is an unpleasant dream that can cause a strong emotional response from the mind, typically fear or horror but also despair, anxiety and great sadness.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Nightmare
梦魇
10029412
nightmare AE
a psychiatric disorder AE that is an anomaly of self-awareness. It consists of a feeling of watching oneself act, while having no control over a situation. Subjects feel they have changed, and the world has become vague, dreamlike, less real, or lacking in significance. It can be a disturbing experience, since many feel that, indeed, they are living in a "dream".
JX, LW, YH
depersonalisation AE
WEB: http://en.wikipedia.org/wiki/Depersonalization
人格解体
10012359
depersonalization AE
a psychiatric disorder AE that refers to a state of mind where one is not disturbed by the passions.
JX, LW, YH
apathia AE
WEB: http://en.wikipedia.org/wiki/Apatheia
情感冷漠
apatheia AE
Parosmia AE is a sensory capability AE that is an olfactory dysfunction which is characterized by the inability of the brain to properly identify an odor’s “natural” smell.
JX, LW, YH
cacosmia AE
troposmia AE
味觉倒错
WEB: http://en.wikipedia.org/wiki/Parosmia
10034018
parosmia AE
Xerophthalmia AE is an eye AE that is a medical condition in which the eye fails to produce tears.
JX, LW, YH
xerophthalmus AE
WEB: http://en.wikipedia.org/wiki/Xerophthalmia
干眼病
10048221
xerophthalmia AE
Chondropathy AE is a bone disorder AE that refers to a disease of the cartilage. It is frequently divided into 5 grades, with 0-2 defined as normal, and 3-4 defined as diseased.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Chondropathy
软骨病
10061762
chondropathy AE
Teratogenesis AE is a female reproductive system AE that is a prenatal toxicity characterized by structural or functional defects in the developing embryo or fetus. It also includes intrauterine growth retardation, death of the embryo or fetus, and transplacental carcinogenesis.
JX, LW, YH
WEB: http://www.britannica.com/EBchecked/topic/587782/teratogenesis
畸胎
teratogenesis AE
Premature atrial contraction AE is an arrhythmia AE that is a common cardiac dysrhythmia characterized by premature heartbeats originating in the atria.
JX, LW, YH
atrial premature beats AE
atrial premature complexes AE
WEB: http://en.wikipedia.org/wiki/Premature_atrial_contraction
早搏
10056964
premature atrial contraction AE
An inflammation AE that courrs in one or both parotid glands, the major salivary glands located on either side of the face, in humans. The parotid gland is the salivary gland most commonly affected by inflammation.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Parotitis
腮腺炎
10034038
parotitis AE
Glossitis AE is an inflammation AE that can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal surface of the tongue, leaving a smooth and erythematous surface.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Glossitis
舌炎
10018386
glossitis AE
Genital edema AE is an edema AE that can be the result of interruption to the lymphatic drainage of this area caused by tumor, surgical removal of lymph nodes, radiotherapy or infection. Congenital disorders causing inadequate lymphatics can sometimes lead to the development of this condition.
JX, LW, YH, MW
WEB: http://www.lymphoedemanz.org.nz/About+Lymphoedema/Genital+Oedema.html
生殖器水肿
10018146
genital edema AE
CTCAE:E13111
NCIt:C78324
Orgasm incapacity AE is a reproductive system AE that the disorder characterized by an inability to achieve orgasm.
JX, LW, YH
缺乏性高潮
orgasm incapacity AE
Sedation AE is a behavior and neurological AE that is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Sedation
镇静
10039897
sedation AE
Sinus bradycardia AE is a bradycardia AE that is a heart rhythm that originates from the sinus node and has a rate that is lower than normal. In humans, bradycardia is generally defined to be a rate of under 60 beats per minute.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Sinus_bradycardia
窦性心动过缓
10040741
sinus bradycardia AE
CTCAE: E10208
NCIt: C26923
Cardiac output decreased AE is a cardiac disorder AE that shows a state in which the blood pumped by an individual's heart is sufficiently reduced that it is inadequate to meet the needs of the body's tissues. Cardiac output is the volume of blood being pumped by the heart, in particular by a left or right ventricle in the time interval of one minute.
JX, LW, YH
WEB: http://www1.us.elsevierhealth.com/MERLIN/Gulanick/archive/Constructor/gulanick10.html
http://en.wikipedia.org/wiki/Cardiac_output
心输出量减少
10007595
cardiac output decreased AE
Steatorrhea AE is a digestive system AE that is the presence of excess fat in feces. Stools may also float due to excess lipid, have an oily appearance and can be especially foul-smelling.
JX, LW, YH
steatorrhoea AE
WEB: http://en.wikipedia.org/wiki/Steatorrhea
脂溢
10041968
steatorrhea AE
Malabsorption syndrome AE is a digestive system AE that refers to a number of disorders in which the intestine’s ability to absorb certain nutrients, such as vitamin B12 and iron, into the bloodstream is negatively affected.
JX, LW, YH
WEB: http://www.healthline.com/health/malabsorption#Overview1
吸收不良综合症
10025479
malabsorption syndrome AE
Sialadenitis AE is an inflammation AE that is inflammation of a salivary gland. It may be subdivided temporally into acute, chronic and recurrent forms.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Sialadenitis
唾液腺炎
10040627
sialadenitis AE
a nervous system AE that shows a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain, the cause of this cell death is unknown.
JX, LW, YH
choreia AE
hypokinetic rigid syndrome AE
idiopathic/primary parkinsonism AE
paralysis agitans AE
WEB: http://en.wikipedia.org/wiki/Parkinson's_disease
帕金森综合症
10061536
parkinson's disease AE
Urinary calculus AE a urinary system AE that is solid particles in the urinary system. They may cause pain, nausea, vomiting, hematuria, and, possibly, chills and fever due to secondary infection.
JX, LW, YH
urinary calculi AE
WEB: http://www.merckmanuals.com/professional/genitourinary_disorders/urinary_calculi/urinary_calculi.html
尿结石
10046531
urinary calculus AE
Sinoatrial block AE is a conduction system disorder AE that shows the electrical impulse is delayed or blocked on the way to the atria, thus delaying atrial depolarization.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Sinoatrial_block
窦房阻滞
10040736
sinoatrial block AE
Hyperthyroidism AE is an endocrine system AE that is a condition in which the thyroid gland produces and secretes excessive amounts of the free (not protein bound circulating in the blood) thyroid hormones -triiodothyronine (T3) and/or thyroxine (T4).
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Hyperthyroidism
甲状腺机能亢进
10020850
hyperthyroidism AE
CTCAE: E10322
NCIt: C3123
Akathisia AE is a behavior and neurological AE that is a movement disorder characterized by a feeling of inner restlessness and a compelling need to be in constant motion, as well as by actions such as rocking while standing or sitting, lifting the feet as if marching on the spot, and crossing and uncrossing the legs while sitting. People with akathisia are unable to sit or keep still, complain of restlessness, fidget, rock from foot to foot, and pace.
JX, LW, YH, MW
acathisia AE
WEB: http://en.wikipedia.org/wiki/Akathisia
静坐困难
10001540
akathisia AE
CTCAE:E12581
NCIt:C78163
Retinopathy AE is an eye AE that is due to persistent or acute damage to the retina of the eye. Ongoing inflammation and vascular remodeling may occur over periods of time where the patient is not fully aware of the extent of the disease. Frequently, retinopathy is an ocular manifestation of systemic disease as seen in diabetes or hypertension.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Retinopathy
视网膜病变
10038923
retinopathy AE
CTCAE: E10432
NCIt: C62601
Sinus arrest AE is an arrhythmia AE that is a medical condition wherein the sinoatrial node of the heart transiently ceases to generate the electrical impulses that normally stimulate the myocardial tissues to contract and thus the heart to beat. It is defined as lasting from 2.0 seconds to several minutes.
JX, LW, YH
sinoatrial arrest AE
sinus pause AE
WEB: http://en.wikipedia.org/wiki/Sinoatrial_arrest
窦性停搏
10040738
sinus arrest AE
ST segment depression AE is an electrocardiogram result abnormal AE that refers to a finding on an electrocardiogram. It may be determined by measuring the vertical distance between the patient's trace and the isoelectric line at a location 2-3 millimeters from the QRS complex. It is significant if it is more than 1 mm in V5-V6, or 1.5 mm in AVF or III.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/ST_depression
ST段下降
10041892
ST segment depression AE
T-wave inversion AE is an electrocardiogram result abnormal AE that can be a sign of coronary ischemia, Wellens' syndrome, left ventricular hypertrophy, or CNS disorder. In electrocardiography, the T wave represents the repolarization (or recovery) of the ventricles.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/T_wave
T波倒置
10042966
T-wave inversion AE
Hyperthermia AE is an abnormal body temperature AE that is elevated body temperature due to failed thermoregulation that occurs when a body produces or absorbs more heat than it dissipates. Extreme temperature elevation then becomes a medical emergency requiring immediate treatment to prevent disability or death.
JX, LW, YH, SJ
WEB: http://en.wikipedia.org/wiki/Hyperthermia
体温过高
10020843
hyperthermia AE
Priapism AE a male reproductive system AE that is a potentially painful medical condition in which the erect penis does not return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Priapism
阴茎持续勃起
10036661
priapism AE
Gingival bleeding AE is a hemorrhage AE that is a term used by dentists and dental hygienists when referring to bleeding that is induced by gentle manipulation of the tissue at the depth of the gingival sulcus, or interface between the gingiva and a tooth. Bleeding on probing, often abbreviated BOP, is a sign of inflammation and indicates some sort of destruction and erosion to the lining of the sulcus or the ulceration of sulcular epithelium. The blood comes from lamina propria after the ulceration of the lining.
JX, LW, YH
bleeding gums AE
bleeding on probing AE
WEB: http://en.wikipedia.org/wiki/Bleeding_on_probing
牙龈出血
10018276
gingival bleeding AE
a hearing disorder AE that is a partial or total inability to hear. In children it may affect the development of language and can cause work related difficulties for adults.
JX, LW, YH
anacusis AE
deafness AE
hard of hearing AE
hearing impaired AE
hearing impairment AE
WEB: http://en.wikipedia.org/wiki/Hearing_loss
听力下降
10019245
10019246
hearing loss AE
CTCAE: E10276
NCIt: C50576
Muscle fatigue AE is a muscle adverse event that is the decline in ability of a muscle to generate force. It can be a result of vigorous exercise but abnormal fatigue may be caused by barriers to or interference with the different stages of muscle contraction.
JX, LW, YH
physical fatigue AE
WEB: http://en.wikipedia.org/wiki/Muscle_fatigue
肌肉疲劳
10049565
muscle fatigue AE
Regurgitation AE is a digestive system AE that is the expulsion of material from the pharynx, or esophagus, usually characterized by the presence of undigested food or blood.
JX, LW, YH
http://en.wikipedia.org/wiki/Regurgitation_%28digestion%29
反胃
10067171
regurgitation AE
Skin irritation AE is a skin AE that is a mild inflammatory dermal tissue reaction, it can be caused by physical contact with an irritant or can be a local response to a systemic trigger.
JX, LW, YH
皮肤刺激
10040880
skin irritation AE
a herpes viral infection AE tha is caused by both Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2).
JX, LW, YH
herpes catarrhalis AE
WEB: http://en.wikipedia.org/wiki/Herpes_simplex
单纯疱疹
10019948
herpes simplex AE
Measles AE is a viral infection AE is an infection of the respiratory system, immune system and skin caused by a virus, specifically a paramyxovirus of the genus Morbillivirus.
JX, LW, YH
English measles AE
morbilli AE
rubeola AE
WEB: http://en.wikipedia.org/wiki/Measles
麻疹
10027011
measles AE
Hypercholesteremia AE is a blood cholesterol abnormal AE that is the presence of high levels of cholesterol in the blood.
JX, LW, YH
cholesterol high AE
dyslipidemia
hypercholesterolemia AE
WEB: http://en.wikipedia.org/wiki/Hypercholesterolemia
高胆固醇血症
10005425
10008661
10020604
hypercholesteremia AE
Toxic epidermal necrolysis AE is a skin AE that is a rare, life-threatening skin condition which is usually caused by a reaction to drugs.
JX, LW, YH, MW
Lyell's syndrome AE
WEB: http://en.wikipedia.org/wiki/Toxic_epidermal_necrolysis
中毒性表皮坏死溶解症
10044223
toxic epidermal necrolysis AE
CTCAE:E13743
NCIt:C79777
Atrioventricular junctional rhythm AE is an arrhythmia AE that is an electrocardiographic finding in which the pacer of the heart is located in the AV junction, presenting with a narrow QRS complex and a rate of 40-60 beats per minute.
JX, LW, YH
房室交界性心律
atrioventricular junctional rhythm AE
Unconsciousness AE is a sensory capability AE that is a state which occurs when the ability to maintain a awareness of self and environment is lost, it involves a complete or near-complete lack of responsiveness to people and other environmental stimuli.
JX, LW, YH
loss of consciousness AE
WEB: http://en.wikipedia.org/wiki/Unconsciousness
意识丧失
10045481
unconsciousness AE
Pemphigus AE is a skin AE that is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Pemphigus
天疱疮
10034280
pemphigus AE
Onychomycosis AE is a nail infection AE that is a fungal infection of the nail. It is the most common disease of the nails and constitutes about half of all nail abnormalities.
JX, LW, YH
dermatophytic onychomycosis AE
tinea unguium AE
WEB: http://en.wikipedia.org/wiki/Onychomycosis
甲癣
onychomycosis AE
Miosis AE is an eye AE that is a term with various definitions, which generally include constriction of the pupil.
JX, LW, YH
myosis AE
WEB: http://en.wikipedia.org/wiki/Miosis
瞳孔缩小
10027646
miosis AE
an optic neuropathy AE that shows the loss of some or most of the nerve fibers in the optic nerve. The effects range from visual change to severe visual loss.
JX, LW, YH
WEB: http://www.kellogg.umich.edu/patientcare/conditions/optic.atrophy.html
视神经萎缩
10030910
optic atrophy AE
Albuminuria AE is a urine abnormality AE that is a pathological condition wherein albumin is present in the urine. It is a type of proteinuria.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Albuminuria
蛋白尿
10001580
albuminuria AE
Enuresis AE is a urine abnormality AE that refers to a repeated inability to control urination. Use of the term is usually limited to describing individuals old enough to be expected to exercise such control.
This term appears to be a synonym to the 'urinary incontinence AE'.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Enuresis
遗尿
10014928
enuresis AE
Gum hypertrophy AE is a digestive system AE that is an increase in the size of the gingiva (gums). It is a common feature of gingival disease. Gingival enlargement can be caused by a number of factors, including inflammatory conditions and the side effects of certain medications.
JX, LW, YH
gingival enlargement AE
gingival hyperplasia AE
gingival hypertrophy AE
gingival over-growth AE
hypertrophic gingivitis AE
WEB: http://en.wikipedia.org/wiki/Gingival_enlargement
牙龈增生
10018781
gum hypertrophy AE
Contact dermatitis AE is a dermatitis AE that is a type of skin inflammation.It results from exposure to allergens (allergic contact dermatitis) or irritants (irritant contact dermatitis). Phototoxic dermatitis occurs when the allergen or irritant is activated by sunlight.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Contact_dermatitis
接触性皮炎
10010790
contact dermatitis AE
Necrotizing vasculitis AE is a vasculitis AE that is a rare condition which involves inflammation of the blood vessel walls.
JX, LW, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000432.htm
坏死性血管炎
10028892
necrotizing vasculitis AE
Carpal tunnel syndrome AE is a peripheral neuropathy AE that is a median entrapment neuropathy that causes paresthesia, pain, numbness, and other symptoms in the distribution of the median nerve due to its compression at the wrist in the carpal tunnel.
JX, LW, YH
median nerve neuropathy AE
WEB: http://emedicine.medscape.com/article/1141168-clinical#showall
WEB: http://en.wikipedia.org/wiki/Carpal_tunnel_syndrome
腕管综合征
10007697
carpal tunnel syndrome AE
Erythromelalgia AE is a peripheral arterial disease AE that is a rare neurovascular peripheral pain disorder in which blood vessels, usually in the lower extremities or hands, are episodically blocked (frequently on and off daily), then become hyperemic and inflamed.
JX, LW, YH
Mitchell's disease AE
acromelalgia AE
erythermalgia AE
red neuralgia AE
WEB: http://en.wikipedia.org/wiki/Erythromelalgia
红斑性肢痛症
10015284
erythromelalgia AE
a syndrome AE which results in the Raynaud's syndrome, a rare disease causes some areas of your body — such as your fingers and toes — to feel numb and cold in response to cold temperatures or stress. In Raynaud's disease, smaller arteries that supply blood to your skin narrow, limiting blood circulation to affected areas (vasospasm).
JX, LW, YH
Raynaud's disease AE
Raynaud's phenomenon AE
WEB: http://www.mayoclinic.org/diseases-conditions/raynauds-disease/basics/definition/con-20022916
雷诺综合症
10037914
Raynaud's syndrome AE
Extrapyramidal syndrome AE is a nervous system AE that is drug induced movement disorders which include acute and tardive symptoms.
JX, LW, YH
extrapyramidal side effects AE
vertebral body outside the beam syndrome AE
WEB: http://en.wikipedia.org/wiki/Extrapyramidal_symptoms
椎体外系综合征
10015836
extrapyramidal syndrome AE
an electrolyte lab test abnormal AE that is when the kidneys hold on to more sodium and do not excrete it with the kidneys. This tends to expand the blood volume, which can elevate the blood pressure.
JX, LW, YH
WEB: https://answers.yahoo.com/question/index?qid=20100823074826AAcg7WV
钠潴留
10041277
sodium retention AE
complex regional pain syndrome AE is a pain AE that results in an uncommon form of chronic pain that usually affects an extremity.
SJ, YH
WEB: http://www.mayoclinic.org/diseases-conditions/complex-regional-pain-syndrome/basics/definition/con-20022844
10064332
Complex regional pain syndrome typically develops after an injury, surgery, stroke or heart attack, but the pain is out of proportion to the severity of the initial injury.
complex regional pain syndrome AE
Sciatica AE is a pain AE that is a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve or by compression or irritation of the left or right or both sciatic nerves.
JX, LW, YH
lumbar radiculopathy AE
sciatic neuralgia AE
sciatic neuritis AE
WEB: http://en.wikipedia.org/wiki/Sciatica
坐骨神经痛
10039674
sciatica AE
Joint stiffness AE is a joint disorder AE that may be either the symptom of pain on moving a joint, the symptom of loss of range of motion or the physical sign of reduced range of motion.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Joint_stiffness
关节僵硬
10023230
joint stiffness AE
Breast engorgement AE is a reproductive system AE that occurs in the mammary glands due to expansion and pressure exerted by the synthesis and storage of breast milk.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Breast_engorgement
乳房充盈
10006240
breast engorgement AE
Nervous tension AE is a behavior and neurological AE that might be said to be a physical expression of how people deal with negatively experienced emotion.
JX, LW, YH
WEB: http://helpmetosleep.org/featured-articles/how-to-relieve-nervous-tension/
神经紧张
10029214
nervous tension AE
Nervousness AE is a behavior and neurological AE that shows an uneasy psychological state which including anxiety, neurosis, neuroticism, and worry, etc.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Nervousness
神经过敏
10029216
nervousness AE
Osteoarthritis AE is an arthritis AE that is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Osteoarthritis is not an inflammatory disease even-though the name suggest one. Symptoms may include joint pain, tenderness, stiffness, locking, and sometimes an effusion.
JX, LW, YH
degenerative arthritis AE
degenerative joint disease AE
osteoarthrosis AE
WEB: http://en.wikipedia.org/wiki/Osteoarthritis
骨关节炎
10031161
osteoarthritis AE
Methemoglobinemia AE is a red blood cell profile abnormal AE that is a disorder characterized by the presence of a higher than normal level of methemoglobin (metHb, i.e., ferric [Fe3+] rather than ferrous [Fe2+] haemoglobin) in the blood. It's a form of hemoglobin that contains ferric [Fe3+] iron and has a decreased ability to bind oxygen.
JX, LW, YH
methaemoglobinaemia AE
WEB: http://en.wikipedia.org/wiki/Methemoglobinemia
高铁血红蛋白症
10027506
methemoglobinemia AE
Hemiageusia AE is a ageusia AE that shows loss of taste from one side of the tongue.
JX, LW, YH
hemiageustia AE
hemigeusia AE
WEB: http://www.medilexicon.com/medicaldictionary.php?t=39885
偏侧味觉缺失
hemiageusia AE
Skin swelling AE is an edema AE that has an outcome of the occurrence of swelling which is located on the skin.
JX, LW, YH
WEB: http://www.rightdiagnosis.com/sym/skin_swelling.htm
胕肿
10053262
skin swelling AE
Fibrosing alveolitis AE is a lung inflammation AE that is a disease of unknown cause mainly involving the gas-exchanging portions of the lungs. It may occur in isolation and be called cryptogenic or idiopathic, in which case the clinical manifestations are mainly respiratory, or it may be associated with other disorders, such as rheumatoid arthritis.
JX, LW, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1818528/
纤维化肺泡炎
10016640
fibrosing alveolitis AE
an electrolyte chloride abnormal AE where the patient's body has abnormally low levels of chloride. This condition usually results from an extremely high loss of chloride, rather than a low intake of it.
JX, LW, YH
WEB: http://www.wisegeek.com/what-is-hypochloremic-alkalosis.htm
低氯性碱中毒
10020958
hypochloremic alkalosis AE
Erythema annulare centrifugum AE is an erythema AE that is a descriptive term for a skin lesion. The lesions form consists of redness (erythema) in a ring form (anulare) that spreads from the center (centrifugum).
JX, LW, YH
MedDRA: 10015154
deep gyrate erythema AE
erythema perstans AE
palpable migrating erythema AE
superficial gyrate erythema AE
WEB: http://en.wikipedia.org/wiki/Erythema_annulare_centrifugum
离心性环形红斑
erythema annulare centrifugum AE
Irritation is a behavior and neurological AE that is a state of inflammation or painful reaction to allergy or cell-lining damage.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Irritation
刺激
10029216
irritation AE
a psychiatric disorder AE that is a fundamental personality trait in the study of psychology characterized by anxiety, fear, moodiness, worry, envy, frustration, jealousy, and loneliness.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Neuroticism
神经质
neuroticism AE
Hyperirritability AE is a behavior and neurological AE that shows abnormally great or uninhibited response to stimuli.
This term appears to be a synonym to the 'irritability AE'.
JX, LW, YH
WEB: http://www.merriam-webster.com/medical/hyperirritability; http://en.wikipedia.org/wiki/Irritability
过激
hyperirritability AE
Rhinostenosis AE is a respiratory system AE that shows narrowing or obliteration of the nasal airway by scar formation
JX, LW, YH
WEB: http://www.drugs.com/dict/rhinostenosis.html
鼻道狭窄
rhinostenosis AE
Sino-auricular heart-block AE is a conduction system disorder AE that refers to a rare heart condition caused by abnormalities in the heart's electrical system rather than arterial disease.
JX, LW, YH
WEB: http://www.rightdiagnosis.com/s/sino_auricular_heart_block/intro.htm
窦房传导阻滞
sino-auricular heart-block AE
Anisosphygmia AE is a cardiovascular disorder AE that shows difference in volume, force, or time of the pulse in the corresponding arteries on two sides of the body, the two radials, or femorals.
JX, LW, YH
WEB: http://www.medilexicon.com/medicaldictionary.php?t=4352
脉搏不规则
anisosphygmia AE
Rubefaction AE is a skin AE that refers to erythema of the skin caused by local application of a counterirritant.
JX, LW, YH
WEB: http://www.medilexicon.com/medicaldictionary.php?t=79112
发红
rubefaction AE
Myodystony AE is an abnormal muscle tone AE that refers to a condition of slow relaxation, interrupted by a succession of slight contractions, following electrical stimulation of a muscle.
JX, LW, YH
WEB: http://www.drugs.com/dict/myodystony.html
肌张力不全
myodystony AE
Allotriosmia is a behavior and neurological AE that shows incorrect recognition of odors.
JX, LW, YH
heterosmia AE
WEB: http://www.medilexicon.com/medicaldictionary.php?t=2401
嗅觉异常
10029216
allotriosmia AE
Pharyngotonsillitis is an inflammation AE that is a medical condition characterized by an inflammation of both the tonsils and the pharynx (located at the back of the throat). It occurs due to viral or bacterial infections.
JX, LW, YH
WEB: http://www.persify.com/en/perspectives/medical-conditions-diseases/pharyngotonsillitis-_-951000101807
咽扁桃体炎
10049140
pharyngotonsillitis AE
Hypersensitivity pneumonitis AE is a pneumonia AE that is an inflammation of the alveoli within the lung caused by hypersensitivity to inhaled organic dusts. Sufferers are commonly exposed to the dust by their occupation or hobbies.
JX, LW, YH
extrinsic allergic alveolitis AE
WEB: http://en.wikipedia.org/wiki/Hypersensitivity_pneumonitis
过敏性肺炎
10015887
hypersensitivity pneumonitis AE
Stagger AE is a movement disorder AE that shows an unsteady movement of the body in walking or standing, as if one were about to fall.
JX, LW, YH
WEB: http://en.wiktionary.org/wiki/stagger
蹒跚
stagger AE
Myocardial anoxia AE is a hypoxia AE that shows a reduced concentration of O2 in the myocardium.
JX, LW, YH
心肌缺氧
myocardial anoxia AE
Biliary colic AE is a pain AE that is the term used to describe a type of pain related to the gallbladder that occurs when a gallstone transiently obstructs the cystic duct and the gallbladder contracts.
JX, LW, YH
cholecystalgia AE
WEB: http://en.wikipedia.org/wiki/Biliary_colic
胆绞痛
10004663
biliary colic AE
Hyperemia AE is a cardiovascular disorder AE that is the increase of blood flow to different tissues in the body. It can have medical implications, but is also a regulatory response, allowing change in blood supply to different tissues through vasodilation.
JX, LW, YH
hyperaemia AE
WEB: http://en.wikipedia.org/wiki/Hyperaemia
充血
hyperemia AE
a sensory capability AE that has an outcome increased sensitivity to pain in a patient
RR
WEB: http://www.oxforddictionaries.com/us/definition/american_english/tenderness
10043224
tenderness AE
a skin AE with the outcome of induration, which is an increase in the fibrous elements in tissue commonly associated with inflammation and marked by loss of elasticity and pliability or a hardened mass or formation
RR
WEB: http://www.merriam-webster.com/medical/induration
10060708
induration AE
an eye AE which has an outcome of a foreign body sensation in the eye, or the sensation that something is in or scratching the eye
RR
WEB: http://www.richmondeye.com/eyehealth_foreignbody/
10051116
foreign body sensation in eyes AE
a cellulititis AE that occurs at an injection-site.
RR
WEB: http://www.nhs.uk/Conditions/Cellulitis/Pages/Symptoms.aspx
10050057
injection site cellulitis AE
a sensory capability AE that has an outcome of peripheral coldness, or coldness of extremeties
RR
WEB: http://www.patient.co.uk/leaflets/peripheral_coldness.htm
10034568
peripheral coldness AE
a hypoaesthesia AE that has an outcome of a decrease in facial sensitivity
RR
hypoaesthesia facial AE
hypoesthesia facial AE
WEB: http://www.webster-dictionary.org/definition/hypoesthesia
10065312
hypoesthesia facial AE
a sleep disorder AE that shows poor quality sleep
RR
10062519
poor quality sleep AE
a rash AE characterized by the formation of vesicles
RR
rash vesicular AE
WEB: http://www.merriam-webster.com/medical/vesicular
10037898
vesicular rash AE
a discomfort AE that occurs at a limb
RR
10061224
limb discomfort AE
an eye disorder AE which has an outcome of discoloration of the sclera, or the whites of the eyes
RR
scleral discolouration AE
10039696
scleral discoloration AE
an urticaria AE that occurs in an injection site
RR
WEB: http://www.uptodate.com/contents/hives-urticaria-beyond-the-basics
10022107
injection site urticaria AE
a behavior and neurological AE that results in dysstasia, or difficulty standing
RR
WEB: http://www.medilexicon.com/medicaldictionary.php?t=27458
10050256
dysstasia AE
a sensory capability AE that has an outcome of hyperaesthesia, meaning unusual or pathological sensitivity of the skin or of a particular sense
RR
hyperaesthesia AE
WEB: http://www.merriam-webster.com/dictionary/hyperesthesia
10020568
hyperesthesia AE
a nuclear magnetic resonance imaging result abnormal AE that has an outcome of abnormal nuclear magnetic resonance imaging test of the spinal cord
RR
10069585
nuclear magnetic resonance imaging spinal cord abnormal AE
an eye disorder AE which has an outcome of ocular icterus, or jaundice of the eye
RR
WEB: http://www.merriam-webster.com/dictionary/icterus
10058117
ocular icterus AE
An edema AE that occurs in the mouth
RR
oedema mouth AE
10030110
edema mouth AE
a respiratory system AE which has an outcome of painful respiration, an unpleasant sensation ranging from mild discomfort to unbearable agony while breathing
RR
WEB: http://www.healthline.com/health/painful-respiration
10033517
painful respiration AE
a neurological, special senses and psychiatric investigation result abnormal AE that results in an abnormal ophthalmological examination
RR
10056836
ophthalmological examination abnormal AE
an optic neuropahty AE which shows an infarction of the optic disk which presents as painless vision loss
RR
optic ischemic neuropathy AE
WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/
WEB: http://www.merckmanuals.com/professional/eye_disorders/optic_nerve_disorders/ischemic_optic_neuropathy.html
10030924
ischemic optic neuropathy AE
a bacterial infection AE with an outcome of Lyme disease, a tick-bourne illness cause by the bacterium B. burgdorferi that causes dermatologic, rheumatologic, neurologic, and cardiac abnormalities
RR
WEB: http://wwwn.cdc.gov/nndss/script/casedef.aspx?CondYrID=752&DatePub=1/1/2011
10025169
lyme disease AE
a pain AE that has an outcome of lymph node pain
RR
10025182
lymph node pain AE
CTCAE: E10052
NCIt: C78440
RR
10024860
a movement disorder AE that has an outcome of loss of control of patient's legs
loss of control of legs AE
a vascular disorder AE that has an outcome of levedo reticularis, a condition of the peripheral blood vessels characterized by reddish blue mottling of the skin especially of the extremeties usually upon exposure to cold
RR
WEB: http://www.merriam-webster.com/medical/livedo%20reticularis
10024648
livedo reticularis AE
a muscle adverse event AE that has an outcome of muscle strain, which happens when a muscle is stretched too much and tears
RR
pulled muscle AE
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001109/
10050031
muscle strain AE
a muscle adverse event AE that has an outcome of muscle tightness, which is a tense feeling in muscles
RR
WEB: http://www.chirocommunity.com/muscletightness.htm
10049816
muscle tightness AE
a muscle adverse event AE that has an outcome of muscle rigidity, a state of continuous firm, tense muscles with marked resistance to passive movement
RR
WEB: http://www.healthline.com/symptom/muscle-rigidity
10028330
muscle rigidity AE
Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barre syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes
RR
WEB: http://www.ninds.nih.gov/disorders/miller_fisher/miller_fisher.htm
10049567
Miller Fisher syndrome AE
a hypersensitivity AE which has an outcome of type III immune complex mediated reaction, a type of hypersensitivity reaction in which circulating antigen-antibody immune complexes are deposited in post-capillary venules, with subsequent complement fixation
RR
WEB: http://emedicine.medscape.com/article/136217-overview
10053614
type III immune complex mediated reaction AE
a tonsilitis AE with the outcome of tonsilar hypertrophy, or enlargement of the tonsils
RR
WEB: http://www.cchi.com.hk/symposia/s3_ear_1.htm
10044003
tonsilar hypertrophy AE
a sensory capability AE that results in temperature intolerance
RR
10057040
temperature intolerance AE
a sensory capability AE that results in the patient being unresponsive to stimuli
RR
10045555
unresponsive to stimuli AE
a respiratory system AE that shows discolored sputum
RR
10041806
sputum discolored AE
a musculoskeletal system AE that has an outcome of spinal column stenosis, or narrowing of spaces in the spine that results in pressure on the spinal cord and/or nerve roots
RR
WEB: http://www.niams.nih.gov/Health_Info/Spinal_Stenosis/
10041540
spinal column stenosis AE
a skin AE with the outcome of skin tightness
RR
10050637
skin tightness AE
a pain AE with the outcome of ligament pain
RR
10068790
ligament pain AE
a thrombocytopenic purpura AE with no known cause (idiopathic). Idiopathic thrombocytopenic purpura is a bleeding disorder in which the immune system destroys platelets, which are necesssary for normal blood clotting. Persons with this disorder have too few platelets in the blood.
RR
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000535.htm
10021245
idiopathic thrombocytopenic purpura AE
a behavior and neurological AE with an outcome of cerebral palsy, a disorder of movement, muscle tone, or posture that is caused by an insult to the immature, developing brain, most often before birth
RR
WEB: http://www.mayoclinic.org/diseases-conditions/cerebral-palsy/basics/definition/con-20030502
10008129
cerebral palsy AE
a neurological AE with the outcome of chronic inflammatory demyelinating polyradiculoneuropathy, a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms caused by damage to the myelin sheath of the peripheral nerves
RR
WEB: http://www.ninds.nih.gov/disorders/cidp/cidp.htm
10057645
chronic inflammatory demyelinating polyradiculoneuropathy AE
an allergy AE which displays an allergic skin response following contact of an allergen, with the skin typically marked by an itchy red rash often accompanied by swelling and watery blisters.
RR, JX, YH
dermatitis allergic AE
WEB: http://www.merriam-webster.com/dictionary/allergic%20contact%20dermatitis
10012434
allergic dermatitis AE
a behavior and neurological AE with an outcome of the patient refusing to eat
RR
10012775
diet refusal AE
an abnormal blood pressure AE that has an outcome of blood pressure fluctuations
RR
10005746
blood pressure fluctuation AE
a digestive system AE which has an outcome of aphagia, which is the loss of the ability to swallow
RR
WEB: http://www.merriam-webster.com/medical/aphagia
10049866
aphagia AE
a speech disorder AE with an outcome of aphonia, or loss of voice and of all but whispered speech
RR, MW
WEB: http://www.merriam-webster.com/dictionary/aphonia
10002953
aphonia AE
CTCAE:E12589
NCIt:C79539
a stomach pain AE that is observed in lower stomach
RR
WEB: http://www.mayoclinic.org/symptoms/abdominal-pain/basics/definition/sym-20050728
10000084
abdominal pain lower AE
an eye AE with an outcome of an abnormal sensation in the eye
RR
10000173
abnormal sensation in eye AE
a behavior and neurological AE which has an outcome of impaired driving ability
RR
10049564
impaired driving ability AE
a respiratory system AE that has an outcome of increased bronchial secretion, or an increase in the substance produced in the bronchial tree, which includes mucus, protein salts, plasma fluid, and proteins
RR
WEB: http://medical-dictionary.thefreedictionary.com/bronchial+secretion
10062530
increased bronchial secretion AE
an injection-site AE that displays injection site streaking, a red pattern on the skin localized to the injection site
RR
WEB: http://www.bannerhealth.com/incfiles/housecalls/peds/FeverInfectionsCrying/ImmunizationReactions.htm
10066778
injection site streaking AE
an injection-site AE that displays injection site streaking, which are small, fluid-filled blisters localized to the injection site
RR
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003939.htm
10022111
injection site vesicles AE
a lab test abnormal AE that has an outcome of an increased international normalized ratio, indicating an individual is more prone to bleeding
RR, MW, YH
INR increased AE
WEB: http://circ.ahajournals.org/content/126/5/e52.full
10022402
10022595
international normalized ratio increased AE
CTCAE: E12175
NCIt: C78366
a sleep disorder AE with the outcome of irregular sleep phase, which is an abnormality in the timing of sleep
RR
WEB: http://www.mayoclinic.org/diseases-conditions/delayed-sleep-phase/basics/definition/con-20035242
10022995
irregular sleep phase AE
an injection-site AE that displays injection site anesthesia, or numbness at the injection site
RR
10022047
injection site anesthesia AE
an infection AE that occurs at an injection-site
RR
WEB: http://www.merriam-webster.com/dictionary/infection
10022076
injection site infection AE
a behavior and neurological AE which has an outcome of decreased grip strength, or a reduction in the force applied by the hand to pull on or suspend from objects
RR
WEB: http://www.krepublishers.com/02-Journals/JLS/JLS-01-0-000-09-Web/JLS-01-1-000-09-Abst-PDF/JLS-01-01-057-09-020-Koley-S/JLS-01-01-057-09-020-Koley-S-Tt.pdf
10062556
grip strength decreased AE
an eye AE with the outcome of eyelid margin crusting
RR
10052132
eyelid margin crusting AE
an ear AE with the outcome of ear discomfort, an uncomfortable or painful feeling in the ear
RR
WEB: http://www.merriam-webster.com/dictionary/discomfort
10052137
ear discomfort AE
an abnormal defecation AE that has an outcome of fecal incontinence, the accidental passing of solid or liquid stool or mucus from the rectum
RR, MW, YH
faecal incontinence AE
WEB: http://digestive.niddk.nih.gov/ddiseases/pubs/fecalincontinence/#what
10016092
10016296
fecal incontinence AE
CTCAE: E10693
NCIt: C78498
a behavior and neurological AE that has an outcome of fear, which is to be afraid and/or worried
RR
WEB: http://www.merriam-webster.com/dictionary/fear
10016275
fear AE
a pain AE that has an outcome of pain in gums
RR
WEB: http://www.merriam-webster.com/dictionary/gingival
10018286
gingival pain AE
CTCAE: E10763
NCIt: C78325
a tongue disorder with the outcome of glossitis, a condition in which the tongue is swollen and changes color, which may make the tongue appear smooth
RR
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001053.htm
10018386
glossitis AE
an injury AE which has an outcome of muscle injury
RR
10028314
muscle injury AE
a sensory capability AE that has an outcome of sensory disturbance
RR
10040026
sensory disturbance AE
an edema AE with an outcome of tracheal edema, which is the swelling of the airway between the throat and the lungs
RR
WEB: http://firstaidcalgary.ca/causes-of-tracheal-edema/
10044296
tracheal edema AE
Allergic eruption AE is a skin AE that is most drug-induced cutaneous reactions, especially found in younger adults. Sometimes also be diagnosed with eczema.
This term appears to be a synonym to the 'eczema AE'.
JX, LW, YH
过敏性皮疹
allergic eruption AE
Erythrodermia AE is a skin AE that is an inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface.
JX, LW, YH
dermatitis exfoliativa AE
exfoliative dermatitis AE
red man syndrome AE
WEB: http://en.wikipedia.org/wiki/Erythroderma
红皮病
10037165
erythrodermia AE
Mycotic dermatitis is a dermatitis AE that is a inflammation of skin which induced by mycetes.
JX, LW, YH
真菌性皮炎
mycotic dermatitis AE
Peritendinitis symptom AE is an inflammation AE that has an outcome of inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.
JX, LW, YH
腱鞘炎样症状
peritendinitis symptom AE
Orthostatic hypotension AE is a hypotension AE that is a form of hypotension in which a person's blood pressure falls when suddenly standing up or stretching. In medical terms, it is defined as a fall in systolic blood pressure of at least 20 mm Hg or diastolic blood pressure of at least 10 mm Hg when a person assumes a standing position.
JX, LW, YH
orthostasis AE
postural hypotension AE
WEB: http://en.wikipedia.org/wiki/Orthostatic_hypotension
直立性低血压
10031127
orthostatic hypotension AE
JX, LW, YH
chromatopsia AE
WEB: http://ghr.nlm.nih.gov/condition/color-vision-deficiency
色视力缺乏
Color vision deficiency AE is an abnormal vision AE that is a group of conditions that affect the perception of color. They cause a range of changes in color vision, from mild difficulty with distinguishing shades to a total inability to detect color. These conditions are divided into three major categories: red-green color vision defects, blue-yellow color vision defects, and a complete absence of color vision.
color vision deficiency AE
Carcinogenesis AE is a tumor AE that is literally the 'creation' of cancer. It is a process by which normal cells are transformed into cancer cells.
JX, LW, YH
oncogenesis AE
tumorigenesis AE
WEB: http://en.wikipedia.org/wiki/Carcinogenesis
致癌
carcinogenesis AE
a circulatory AE that is a serious allergic reaction associated with systemic vasodilation that causes low blood pressure which is by definition 30% lower than the person's baseline or below standard values.
JX, LW, YH, RR
WEB: http://en.wikipedia.org/wiki/Anaphylaxis
WEB: http://smschile.cl/documentos/cursos2010/MedicalClinicsNorthAmerica/Acute%20Symptoms%20of%20Drug%20Hypersensitivity%20%28Urticaria,%20Angioedema,%20Anaphylaxis,%20Anaphylactic%20Shock%29.pdf
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=10092
过敏性休克
10002199
anaphylactic shock AE
Pituitary adenomas AE is a tumor AE that is a tumor which occur in the pituitary gland. Pituitary adenomas are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, and carcinomas, with carcinomas accounting for 0.1% to 0.2%, approximately 35% being invasive adenomas and most being benign adenomas. Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms and the estimated prevalence rate in the general population is approximately 17%.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Pituitary_adenoma
pituitary adenomas AE
Fatty infiltration AE is an embolism AE that shows the abnormal accumulation of fat droplets in the cytoplasm of cells.
JX, LW, YH
WEB: http://dictionary.reference.com/browse/fatty+infiltration
脂肪侵润
fatty infiltration AE
Epigastric discomfort is a discomfort AE that shows discomfort in the upper central region of the abdomen.
JX, LW, YH
upper Abdominal discomfort AE
WEB: http://www.rightdiagnosis.com/sym/epigastric_discomfort.htm
上腹部不适
10053155
epigastric discomfort AE
Acute intravascular hemolysis AE is a cardiovascular AE that has an outcome of disruption of red blood cells occurs while they are within blood vessels.
JX, LW, YH
急性血管内溶血
acute intravascular hemolysis AE
Allergic hepatitis AE is a hepatitis AE that is a tissue-specific inflammatory diease caused by hepersensitivity to a particular drug, accomopanied by a systemic allergic reaction such as eosinophilia.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/viral+hepatitis
过敏性肝炎
10071198
allergic hepatitis AE
Paranoid anxiety AE is a anxiety AE that is a term used in object relations theory, particularity in discussions about the Paranoid-schizoid and depressive positions. The term was frequently used by Melanie Klein, especially to refer to a pre-depressive and persecutory sense of anxiety characterised by the psychological splitting of objects.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Paranoid_anxiety
偏执性焦虑
paranoid anxietas AE
Thrombotic thrombocytopenic purpura AE is a thrombocytopenic purpura AE that is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body.
JX, LW, YH
moschcowitz syndrome AE
WEB: http://en.wikipedia.org/wiki/Thrombotic_thrombocytopenic_purpura
血栓性血小板减少性紫癜
10043648
thrombotic thrombocytopenic purpura AE
CTCAE: E10061
NCIt: C78797
Glaucoma AE is an eye AE that is a term describing a group of ocular (eye) disorders resulting in optic nerve damage or loss to the field of vision, in many patients caused by a clinically characterized pressure buildup in regards to the fluid of the eye (intraocular pressure-associated optic neuropathy).
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Glaucoma
青光眼
10018304
glaucoma AE
CTCAE: E10392
NCIt: C26782
an allergy AE that shows a serious allergic reaction that is rapid in onset and may cause death. It typically causes a number of symptoms including an itchy rash, throat swelling, and low blood pressure. Common causes include insect bites and stings, foods, and medications.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Anaphylaxis
过敏症
10002218
anaphylaxis AE
CTCAE: E11254
NCIt: C50460
an allergy AE which occur during certain times of the year, usually when outdoor molds release their spores, and trees, grasses, and weeds release tiny pollen particles into the air to fertilize other plants.
JX, LW, YH
WEB: http://kidshealth.org/parent/medical/allergies/seasonal_allergies.html
季节性变态反应
10048908
seasonal allergy AE
a blood sodium abnormal AE with an abnormally decreased sodium concentration in the blood
YH, MW
hyponatraemia AE
WEB: http://www.mayoclinic.org/diseases-conditions/hyponatremia/basics/definition/con-20031445
10021036
10021038
hyponatremia AE
CTCAE: E12339
NCIt: C37976
Skin redness AE is an erythema AE that is abnormal redness of the skin, often signaling a pathological condition, such as inflammation, infection, or sunburn.
JX, LW, YH
WEB: http://www.healthline.com/health/skin-redness
皮肤发红
skin redness AE
a chest pain that is caused when your heart muscle doesn't get enough oxygen-rich blood.
DJ, SS, YH
chest pain - cardiac AE
tight chest AE
WEB: http://www.ncbi.nlm.nih.gov/pubmed/23016723
10002383
10008481
angina AE
CTCAE: E10110
HPO: HP_0001681
NCIt: C51221
SIDER: C0002962
an angina AE that is aggravating.
JX, YH
aggravating angina AE
an aggravating angina AE that is caused by severe hypotension
JX, YH
严重低血压导致心绞痛症状加重现象
severe hypotension caused angina symptom aggravating AE
an eye AE that shows abnormal involuntary blinking of the eyelids
JX, LW, YH
corneal reflex abnormal AE
URL: https://en.wikipedia.org/wiki/Corneal_reflex
睑闭反射反常
10058960
blink reflex abnormal AE
Dazzling AE is a eye disorder AE that has an outcome of the consequence of illumination too intense for adaptation by the eye. In contrast to glare, dazzling is alleviated by appropriate tinted glasses.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/dazzling
目眩
dazzling AE
Ventricular rhythm AE is an arrhythmia AE that shows the electrocardiographic finding of an ectopic ventricular rhythm with three or more consecutive ventricular premature beats with a rate less than 100 beats per minute.
JX, LW, YH
室性心律
10047297
ventricular rhythm AE
Extrapyramidal signs AE is a nervous system AE that shows defects in basal ganglia function. It characterized by changes in muscle tone, poverty of voluntary movements (akinesia), or abnormal involuntary movements (dyskinesia).
JX, LW, YH
锥体外体征
extrapyramidal signs AE
Hearing disorder AE is an ear disorder that shows impairment of the sense of hearing.
JX, LW, YH
听觉障碍
10019243
hearing disorder AE
Yellow urine AE is a urine abnormality AE that may be due to excretion of picric acid, dinitrophenol, phenacetin or chrysarobin or in alkaline pH, to increased secretion of anthocyanin, or associated with ingestion of beets or blackberries. Pure yellow urine is associated with increased acriflavine and has a green fluorescence; yellow-orange urine may be highly concentrated or contain increased bilirubin and biliverdin.
JX, LW, YH
尿液呈黄色
yellow urine AE
Epidermal necrosis AE is a necrosis AE that shows widespread keratinocyte cell death via apoptosis results in the tissue damage.
JX, LW, YH
表皮坏死
10059284
epidermal necrosis AE
Arthromeningitis AE is an inflammation AE that shows inflammation of a synovial membrane, usually painful, particularly on motion, and characterized by fluctuating swelling, due to effusion in a synovial sac.
JX, LW, YH
滑膜炎
arthromeningitis AE
Pulmonary tuberculosis AE is a lung disorder AE that is a contagious bacterial infection that involves the lungs. It may spread to other organs.
JX, LW, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000077.htm
10037440
pulmonary tuberculosis AE
Coronary heart disease AE is a cardiovascular disorder AE that is a disease in which a waxy substance called plaque (plak) builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle.
JX, LW, YH
WEB: http://www.nhlbi.nih.gov/health/health-topics/topics/cad/
冠心病
10068617
coronary heart disease AE
Increased defecation frequency AE is a abnormal stool AE that shows defecation number increased.
JX, LW, YH
大便次数增加
increased defecation frequency AE
Symptomatic hypotension AE is a hypotension AE that shows blood pressure that less than 90/60 mm Hg with dizziness, vertigo etc.
JX, LW, YH
症状性低血压
symptomatic hypotension AE
Non-specific gastrointestinal dysfunction AE is a gastrointestinal disorder AE that shows non-specific gastrointestinal dysfunction.
JX, LW, YH
非特异性胃肠功能紊乱
non-specific gastrointestinal dysfunction AE
Abnormal sclerotin AE is a bone disorder AE that shows abnormal sclerotin.
JX, LW, YH
骨质异常
abnormal sclerotin AE
Fast and weak heart beat AE is a cardiac disorder AE that shows fast and weak heart beat.
JX, LW, YH
心跳快而弱
fast and weak heart beat AE
Pain over the liver AE is a pain AE that shows pain over the liver.
JX, LW, YH
肝区痛
pain over the liver AE
Increased biliary calculus AE is a liver, biliary, and pancreatic AE that shows increased biliary calculus.
JX, LW, YH
胆石增加
increased biliary calculus AE
Muscle function disorder AE is a muscle AE that shows muscle function disorder.
JX, LW, YH
肌肉功能失调
muscle function disorder AE
Accidental injury AE is a fall AE that shows accidental falls.
JX, LW, YH
意外跌倒
accidental fall AE
Accidental injury AE is an injury AE that shows accidedntal injury.
JX, LW, YH
意外损伤
10000380
accidental injury AE
Abnormal ejaculation AE is a male reproductive system AE that shows abnormal ejaculation.
JX, LW, YH
异常射精
10000128
abnormal ejaculation AE
Distention of head AE is a cardiovascular AE that shows distention of head.
JX, LW, YH
头胀
distention of head AE
Water-sodium retention AE is an abnormal fluid regulation AE that shows water-sodium retention.
JX, LW, YH
WEB: http://www.livestrong.com/article/485782-sodium-retention-weight-gain/
水钠潴留
water-sodium retention AE
Dizziness when standing up AE is a dizziness AE that shows dizziness when standing up.
JX, LW, YH
站起时头晕
dizziness when standing up AE
Change of gustation AE is a gustatory system AE that shows the change of gustation.
JX, LW, YH
味觉改变
change of gustation AE
Vascular stimulation of pain AE is a pain AE that shows pain which due to vascular stimulation.
JX, LW, YH
血管刺激性疼痛
vascular stimulation of pain AE
Vascular pain AE is a pain AE that shows vascular pain.
JX, LW, YH
血管疼痛
vascular pain AE
Heaviness sense of arm AE is a sensation of heaviness AE that shows a sensation feeling of heaviness in the arm.
JX, LW, YH
手臂沉重感
heaviness sense of arm AE
Breast swelling AE is an edema AE that is common for almost all women in the second half of their menstrual cycle. It in the premenstrual portion of the cycle can be mild to severe.
JX, LW, YH
WEB: http://www.healthgrades.com/symptoms/breast-swelling
乳房肿胀
10006312
breast swelling AE
Gastrointestinal cramp AE is a muscle spasm AE that shows abnormal contractions of the gastrointestinal muscles.
JX, LW, YH
肠胃痉挛
10049136
gastrointestinal cramp AE
Heart discomfort AE is a discomfort AE that shows an uncomfortable feeling in the heart.
JX, LW, YH
心脏不适
heart discomfort AE
Angiectopia of skin AE a vascular disorder AE that shows abnormal position or course of a vessel in the skin.
JX, LW, YH
皮肤血管异位
angiectopia of skin AE
Joint discomfort AE is a discomfort AE that shows an uncomfortable feeling in the joint.
JX, LW, YH
关节不适
joint discomfort AE
Eye discomfort AE is a discomfort AE that shows an uncomfortable feeling in the eye.
JX, LW, YH
眼部不适
eye discomfort AE
Instability of gait AE is a abnormal gait AE that shows instability of gait.
JX, LW, YH
步态不稳
instability of gait AE
Pemphigoid injury AE is an injury AE that shows a skin disorder where one has large blisters on the skin.
JX, LW, YH
类天疱疮样损伤
pemphigoid injury AE
Pulse frequency change AE is a cardiovascular AE that shows dpulse frequency change.
JX, LW, YH
pulse abnormal AE
脉搏频率变化
pulse frequency change AE
Inhibition of myocardial contraction force AE is a cardiac disorder AE that shows inhibition of myocardial contraction force.
JX, LW, YH
抑制心肌收缩力
inhibition of myocardial contraction force AE
Decreased of atrial conduction velocity AE is a conduction system disorder AE that shows decreased of atrial conduction velocity.
JX, LW, YH
心房传导速度减慢
decreased of atrial conduction velocity AE
Spasm of lower limbs AE is a muscle spasm AE that shows tightening and spasms of the muscles in the legs.
JX, LW, YH
下肢痉挛
spasm of lower limbs AE
Electrocardiogram prolonged PR interval AE is an electrocardiogram result abnormal AE that shows a prolonged time between the onset of atrial depolarization (P wave) to the beginning of ventricular depolarization (QRS complex).
JX, LW, YH
心电图出现PR间期延长
electrocardiogram prolonged PR interval AE
Qrs wave broadening AE is a electrocardiogram qrs complex abnormal AE that shows broadening qrs complex in the electrocardiogram.
JX, LW, YH
QRS波增宽
qrs wave broadening AE
Edema of lower limbs AE is an edema AE that shows enlargement of the leg, due to the accumulation of fluids.
JX, LW, YH
下肢浮肿
edema of lower limbs AE
Accelerated pulse AE is a cardiovascular AE that shows increased of the number of pulsations per minute palpable in an artery.
JX, LW, YH
脉搏加快
accelerated pulse AE
Bitter taste of mouth AE is a digestive system AE that is not from a bitter substance is a distorted sense of taste. A persistent bad taste in the mouth, whether bitter, metallic or foul, is called dysgeusia.
JX, LW, YH
WEB: http://www.healthgrades.com/symptoms/bitter-taste-in-mouth
口苦
bitter taste of mouth AE
Skin irritant reaction AE is a skin AE that shows rash, inflammation, swelling, scaling, or abnormal tissue which growth in the affected area.
JX, LW, YH
皮肤刺激反应
skin irritant reaction AE
Vitreous suspended substance AE is an eye AE shows vitreous suspended substance in the eyes.
JX, LW, YH
玻璃体悬浮物
vitreous suspended substance AE
Dreaminess AE is a sleep disorder AE that shows dreaminess in the sleeping.
JX, LW, YH
多梦
dreaminess AE
Abdominal spasm AE is a muscle spasm AE that is typically a feeling of cramping in the abdomen caused by a rigid expansion of muscles. It can vary from mild discomfort to moderate or severe pain.
JX, LW, YH
WEB: http://www.wisegeekhealth.com/what-are-abdominal-spasms.htm
腹部痉挛
10051889
abdominal spasm AE
Coronary contraction AE is a coronary artery disorder AE that shows coronary contraction.
JX, LW, YH
冠状动脉收缩
coronary contraction AE
Lower extremity edema caused by blood vessels AE is an edema AE that shows excess fluid accumalated in the leg dut to blood vessels.
JX, LW, YH
因血管扩张引起的下肢水肿
lower extremity edema caused by blood vessels AE
Asthenia of lower limbs AE is a asthenia AE that occurs in the lower limbs. It is a condition typified by a weakness of voluntary movement.
JX, LW, YH
下肢无力
asthenia of lower limbs AE
Small bronchial lumen occlusion AE is a lung disorder AE that shows small bronchial lumen occlusion.
JX, LW, YH
小支气管腔闭塞
small bronchial lumen occlusion AE
Prolonged orthostatic hypotension AE is a orthostatic hypotension AE that shows prolonged orthostatic hypotension.
JX, LW, YH
延长体位性低血压时间
prolonged orthostatic hypotension AE
an allergy AE that shows produce cross or incomplete cross allergic reaction to similar medicinal chemistry structure.
JX, LW, YH
交叉过敏反应
cross allergic reaction AE
Deep venous thrombophlebitis AE is a thrombophlebitis AE that is causes by a blood clot blocking in the deep vein.
JX, LW, YH
深静脉血栓静脉炎
deep venous thrombophlebitis AE
Change of hematology AE is a hematology investigation result abnormal AE that shows the change of hematology.
JX, LW, YH
血液学改变
change of hematology AE
Cardiac depression AE is a cardiac disorder AE that shows cardiac depression.
JX, LW, YH
抑制心脏
cardiac depression AE
Side limb numbness AE is a numbness AE that shows reduced or loss of sensation on the skin of an arm and leg on the same side of the body.
JX, LW, YH
侧肢的麻木感
side limb numbness AE
Numbness of tongue AE is a numbness AE that shows abnormal feeling or loss of sensation in the tongue.
JX, LW, YH
舌部麻木
numbness of tongue AE
Numbness of the limbs AE is a numbness AE that shows reduced or loss of sensation on the skin of the arm and leg.
JX, LW, YH
肢体麻木
numbness of the limbs AE
Lip numbness AE is a numbness AE that shows abnormal feeling in the lips, including numbness and tingling.
JX, LW, YH
嘴唇发麻
lip numbness AE
Reflex Increased pulse rate AE is a cardiovascular AE that shows increased pulse rate.
JX, LW, YH
反射性脉率增加
reflex Increased pulse rate AE
Irritation of the digestive tract AE is a digestive system AE that shows irritation of the digestive tract.
JX, LW, YH
消化道刺激
irritation of the digestive tract AE
Unconscious chorea AE is a chorea AE that is characterized by brief, non-repetitive irregular muscle contractions.
JX, LW, YH
不自觉舞蹈症
unconscious chorea AE
Phlebectasia of limbs AE is a vasodilatation AE that shows dilation of the veins in the extremity.
JX, LW, YH
肢端静脉扩张
phlebectasia of limbs AE
Heart beat skip AE is a irregular heartbeat AE which is sometimes called as either heart palpitation, or premature atrial or ventricular contraction are very common occurrences. They may or may not be accompanied by heart conditions or heart problems.
JX, LW, YH
WEB: http://ehealthwall.com/heart-skips-a-beat-causes-symptoms-treatment/
漏跳
heart beat skip AE
Fatal liver cell necrosis AE is a hepatic necrosis AE that has an outcome of fatal liver cell necrosis.
JX, LW, YH
致命性肝细胞坏死
fatal liver cell necrosis AE
Warm and hot feeling in the neck AE is a skini warm AE that shows warm and hot feeling in the neck.
JX, LW, YH
颈感觉温热
warm and hot feeling in the neck AE
Facial warm feeling AE is a skin warm AE that shows a warm feeling in the face.
JX, LW, YH
面部感觉温热
facial warm feeling AE
Increased peripheral vascular resistance AE is a vascular disorder AE that shows increased peripheral vascular resistance, the degree to which the blood vessels impede the flow of blood. High resistance causes an increase in blood pressure, which increases the workload of the heart.
JX, LW, YH
外周血管阻力升高
increased peripheral vascular resistance AE
Venous ischemia AE is an ischaemia AE that shows in insufficient blood supply in the vein.
JX, LW, YH
静脉供血不足
venous ischemia AE
Increased blood creatine AE is a metabolic and nutritional investigation result abnormal AE that shows an increased creatine level in blood.
JX, LW, YH
血肌酸增加
increased blood creatine AE
Increased nonprotein nitrogen AE is an investigation result abnormal AE that shows increased nonprotein nitrogen, the nitrogenous constituents of the blood exclusive of the protein bodies, consisting of the nitrogen of urea, uric acid, creatine, creatinine, amino acids, polypeptides, and an undetermined part known as rest nitrogen.
JX, LW, YH
非蛋白氮增加
increased nonprotein nitrogen AE
Soft feces AE is a abnormal stool AE that shows soft and shapeless of the feces.
JX, LW, YH
软便
soft feces AE
Increased hepatic function AE is a hepatic function abnormal AE that shows the values of liver function tests (LFTs) high than the normal.
JX, LW, YH
WEB: http://www.webmd.com/a-to-z-guides/liver-function-test-lft
肝功能升高
increased hepatic function AE
Knee pain AE is a pain AE that shows discomfort in the structures of both knees. Keen pain may be due to injury, inflammation or infection.
JX, LW, YH
WEB: http://www.mayoclinic.org/diseases-conditions/knee-pain/basics/definition/CON-20029534
膝痛
10023477
knee pain AE
Loss of libido AE is a libido disorder AE that shows loss of the desire for sexual interaction.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder
性欲丧失
10024870
loss of libido AE
Over sedation AE is a behavior and neurological AE that shows the over reduction of irritability or agitation.
JX, LW, YH
过度镇静
over sedation AE
Finger tremor AE is a tremor AE that shows involuntary muscle contraction and relaxation in the finger.
JX, LW, YH
手指强硬颤动
finger tremor AE
Leg cramp AE is a muscle cramp AE that shows tightening, or spasms, of the muscles in the legs.
JX, LW, YH
腿部痉挛
leg cramp AE
a sleep disorder AE in which there is an inability to fall asleep or to stay asleep as long as desired.
YH, MW
WEB: https://en.wikipedia.org/wiki/Insomnia
10022437
Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity. Insomnia is a symptom, not a stand-alone diagnosis or a disease.
insomnia AE
CTCAE: E12925
HPO: HP_0002360
SIDER: C0917801
Terminal insomnia AE is a insomnia AE that is a medical condition affecting sleep patterns. Typically, people who suffer from terminal insomnia wake up after only four to five hours of sleep. For those afflicted, getting back to sleep can be difficult, resulting in fatigue, irritability, and lack of concentration.
JX, LW, YH
matutinal insomnia AE
WEB: http://www.wisegeek.com/what-is-terminal-insomnia.htm
早醒
10068932
terminal insomnia AE
Bone marrow granuloma AE is a bone marrow disorder AE that shows an organized collection of macrophages in the bone marrow.
JX, LW, YH
骨髓肉芽肿
10066816
bone marrow granuloma AE
Cholestatic liver injury AE is a liver damage AE that shows buildup of bile acids in hepatocytes, then causes hepatocellular injury.
JX, LW ,YH
胆汁郁积性肝损伤
10067969
cholestatic liver injury AE
Distant heart sounds AE is a cardiac disorder AE that shows distant heart sounds.
JX, LW, YH
心音遥远
distant heart sounds AE
Pink skin AE is a skin AE that shows pink skin.
JX, LW, YH
皮肤粉红
pink skin AE
Acute laryngeal edema AE is an edema AE that shows acute laryngeal edema, abnormal accumulation of fluid in tissues of any part of the larynx, commonly associated with laryngeal injuries and allergic reactions.
JX, LW, YH
急性喉头水肿
10066705
acute laryngeal edema AE
Hypoplastic bone marrow AE is a bone marrow disorder AE that shows insufficient blood stem cells in the marrow.
JX, LW, YH
骨髓发育不全
hypoplastic bone marrow AE
Bleeding and coagulation disorders AE is a hematopoietic system AE that shows bleeding and coagulation disorders.
JX, LW, YH
出凝血功能障碍
bleeding and coagulation disorders AE
Polymorphic ventricular tachycardia AE is a ventricular tachycardia AE that is an abnormally fast heart rhythm starting in the ventricles, the lower chambers of the heart.
JX, LW, YH
WEB: http://www.healthguideinfo.com/arrhythmias-heart-palpitations/p110132/
多行性室性心动过速
10036095
polymorphic ventricular tachycardia AE
Monomorphic ventricular tachycardia AE is a ventricular tachycardia AE that is a type of tachycardia which has a uniform beat-to-beat QRS morphology.
JX, LW, YH
单行性室性心动过速
10058185
monomorphic ventricular tachycardia AE
Respiratory tract symptoms AE is a respiratory system AE that is a series of discomforts which occurs in respiratory tract.
JX, LW, YH
呼吸道症状
respiratory tract symptoms AE
Clammy skin AE is a skin AE that occurs when the skin turns cooler than normal and is moist, despite a cooler surface temperature. Clammy skin is often pale.
JX, LW, YH
WEB: http://www.healthgrades.com/symptoms/clammy-skin
皮肤湿冷
clammy skin AE
Abnormal visual accommodation AE is an abnormal vision AE that shows abnormal visual accommodation. Accommodation is the process by which the vertebrate eye changes optical power to maintain a clear image or focus on an object as its distance varies.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Accommodation_%28eye%29
视调节异常
abnormal visual accommodation AE
an allergy AE that shows swelling and irritation of the skin, caused by an allergy to a substance in the environment.
JX, LW, YH
皮肤过敏
skin allergy AE
Heaviness of the head AE is a sensation of heaviness AE that shows a sensation feeling of heaviness in the head.
JX, LW, YH
头重感
10049121
heaviness of the head AE
Rheumatoid factor positive AE is an immunology and allergy investigation result abnormal AE that shows positive of the rheumatoid factor. Rheumatoid factor is a blood test that measures the amount of the RF antibody in the blood.
JX, LW, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003548.htm
类风湿因子阳性
10039080
rheumatoid factor positive AE
Retinal detachment AE is an eye AE that is a separation of the retina from its attachments to the underlying tissue within the eye.
JX, LW, YH
WEB: http://www.medicinenet.com/retinal_detachment/article.htm
视网膜脱离
10038848
retinal detachment AE
CTCAE: E10420
NCIT: C26874
NCIt: C26874
Arm pain AE is a pain AE that shows discomfort in the structures of the arm. It can be caused by a wide variety of problems, ranging from joint injuries to compressed nerves.
JX, LW, YH
WEB: http://www.mayoclinic.org/symptoms/arm-pain/basics/definition/SYM-20050870
手臂疼痛
arm pain AE
Peripheric paresthesia AE is a paresthesia AE that shows paresthesia in the peripheric area.
JX, LW, YH
外周感觉异常
peripheric paresthesia AE
Edema of glottis AE is an edema AE that is a swelling caused by fluid accumulation in the soft tissues of the larynx. The condition, usually inflammatory, may result from an infection, injury, allergy, or inhalation of toxic substances.
JX, LW, YH
声门肿胀
edema of glottis AE
Prolonged qrs complex AE is a electrocardiogram qrs complex abnormal AE that shows qrs complex prolonged. The QRS complex is a name for the combination of three of the graphical deflections seen on a typical electrocardiogram.
JX, LW, YH
QRS时间延长
prolonged qrs complex AE
Prolonged bleeding time AE is a hematology investigation result abnormal AE that shows prolonged time for small blood vessels in the skin close to stop from bleeding.
JX, LW, YH
出血时间延长
prolonged bleeding time AE
Acute generalized exanthematous pustulosis AE is a skin AE that is a not uncommon cutaneous reaction pattern that in 90% of cases is related to medication administration, characterized by a sudden eruption that appears on average five days after the medication is started.
JX, LW, YH
pustular drug eruption AE
toxic pustuloderma AE
WEB: http://en.wikipedia.org/wiki/Acute_generalized_exanthematous_pustulosis
急性全身性浓疱病
10062372
acute generalized exanthematous pustulosis AE
Upper and lower limbs flare AE is an edema AE that shows edema in the upper and lower limbs, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues.
JX, LW, YH
上下肢红肿
upper and lower limbs flare AE
Abnormal blood sugar with empty stomach AE is a blood glucose level abnormal AE that shows abnormal blood glucose level with empty stomach.
JX, LW, YH
空腹时血糖异常
abnormal blood sugar with empty stomach AE
Increased blood sugar with empty stomach AE is blood glucose level decreased AE that shows an increased glucose level in blood with empty stomach.
JX, LW, YH
空腹时血糖升高
increased blood sugar with empty stomach AE
Hydrochloric acid in gastric juice secretion increased AE is a gastric disorder AE that shows increased gastric acid.
JX, LW, YH
胃酸分泌增多
hydrochloric acid in gastric juice secretion increased AE
Torsades de pointes AE is a ventricular tachycardia AE that is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Torsades_de_pointes
扭转性室速
10044067
torsades de pointes AE
Proximal myasthenia AE is a myasthenia AE that shows proximal myasthenia. Myasthenia represents myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatigability.
JX, LW, YH
近端肌无力
proximal myasthenia AE
Dilated skin vessels AE is a vasodilatation AE that shows vasodilatation in the skin, which refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins.
JX, LW, YH
皮肤血管扩张
dilated skin vessels AE
Numbness of oral mucosa AE is a numbness AE that shows an abnormal feeling or loss of sensation in the oral mucosa.
JX, LW, YH
口腔黏膜发麻
numbness of oral mucosa AE
Orthostatic dizziness AE is a dizziness AE that shows dizziness provocation by sudden postural change.
JX, LW, YH
体位性头晕
10031125
orthostatic dizziness AE
Acid reflux AE is a digestive system AE that shows the acid and pepsin secreted in the stomach back up in to the esophagus.
JX, LW, YH
反酸
10066872
acid reflux AE
Jugular phlebectasia AE is a vasodilatation AE that is an isolated saccular or fusiform dilation of a vein without tortuosity.
JX, LW, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708235/
颈静脉扩张
jugular phlebectasia AE
Laryngeal edema AE is an edema AE that shows abnormal accumulation of fluid in tissues of any part of the larynx, commonly associated with laryngeal injuries and allergic reactions.
JX, LW, YH, MW
laryngeal oedema AE
喉肿胀
10023838
laryngeal edema AE
CTCAE:E13393
NCIt:C79607
Flatus AE is a digestive system AE that shows gas or air expelled through the anus.
JX, LW, YH
排气
10016769
flatus AE
Continuous polymorphic ventricular tachycardia AE is a polymorphic ventricular tachycardia AE that shows polymorphic ventricular tachycardia is constantly.
JX, LW, YH
连续性多形性室性心动过速
continuous polymorphic ventricular tachycardia AE
Continuous polymorphic ventricular tachycardia AE is a polymorphic ventricular tachycardia AE that shows polymorphic ventricular tachycardia is intermittent.
JX, LW, YH
间歇性多形性室性心动过速
intermittent polymorphic ventricular tachycardia AE
Aggravated ulcer AE is a ulcer AE that shows aggravated ulcer.
JX, LW, YH
溃疡加重
aggravated ulcer AE
Heart failure increased AE is a cardiovascular disorder AE that shows aggravated heart failure.
JX, LW, YH
心脏衰竭加重
heart failure increased AE
Aggravated angina symptoms AE is a angina pectoris AE that shows aggravated angina symptoms.
JX, LW, YH
心绞痛症状加剧
aggravated angina symptoms AE
Aggravated renal injury AE is a renal impairment AE that shows aggravated renal injury.
JX, LW, YH
肾损害加剧
aggravated renal injury AE
Aggravated fatigue AE is a fatigue AE that shows aggravated fatigue.
JX, LW, YH
脱力感加重
aggravated fatigue AE
Persistent nausea AE is a nausea AE that shows constant nausea. Nausea is considered "persistent" if it continues for more than 2 days, or keeps recurring even after treatment.
JX, LW, YH
WEB: http://www.all4naturalhealth.com/persistent-nausea.html
持续恶心
persistent nausea AE
Aggravated Raynaud's syndrome AE is a Raynaud's syndrome AE that shows aggravated Raynaud's syndrome.
JX, LW, YH
Raynaud综合征加重
aggravated Raynaud's syndrome AE
Increased gastric acid secretion with high dose AE is a gastric disorder AE that shows increased gastric acid secretion with high dose.
JX, LW, YH
高剂量时胃酸分泌增加
increased gastric acid secretion with high dose AE
Persistent vomiting AE is a vomiting AE that occurs frequently throughout the day and is often triggered by even small meals.
JX, LW, YH
WEB: http://www.healthhype.com/persistent-and-recurrent-vomiting-emesis-in-adults-and-children.html
持续呕吐
10034716
persistent vomiting AE
Hypoacusis AE is a hearing disorder AE that shows partial or complete loss of the ability to detect or understand sounds resulting from damage to the outer, middle, or inner ear structures. Causes include exposure to loud noise, ear infections, injuries to the ear, genetic, and congenital disorders.
JX, LW, YH
WEB: http://medical-dictionary.thefreedictionary.com/hypoacusis
突发听力减退
10048865
hypoacusis AE
Lip cyanosis AE is a cyanosis AE that is a condition in which the lips have a bluish discoloration due to a lack of oxygen in the tissues.
JX, LW, YH
WEB: http://www.rightdiagnosis.com/sym/lip_cyanosis.htm
嘴唇发紫
lip cyanosis AE
Nail cyanosis AE is a cyanosis AE that shows a dark bluish or purple nail resulting from deficient oxygenation of the blood.
JX, LW, YH
指甲青紫
nail cyanosis AE
Renal dysfunction AE is a kidney AE that has an outcome of reduced capacity to excrete metabolic products which accumulate systemically and are detectable clinicopathologically by renal function tests. The early stage of uremia.
This term appears to be a synonym to the 'renal failure AE'.
JX, LW, YH
hepatic and renal function disorder AE
肾功能障碍
renal insufficiency AE
UMLS ID: C0859242
JX, LW, YH
Hemolysis AE is a hematopoietic system AE that is the rupturing of erythrocytes (red blood cells) and the release of their contents (cytoplasm) into surrounding fluid.
WEB: http://en.wikipedia.org/wiki/Hemolysis
溶血
10019491
hemolysis AE
CTCAE: E10037
NCIt: C37965
Lip angioedema AE is a angioedema AE that shows lip angioedema, which is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues.
JX, LW, YH
唇血管神经性水肿
lip angioedema AE
Tongue angioedema AE is a angioedema AE that shows tongue angioedema, which is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues.
JX, LW, YH
舌血管神经性水肿
tongue angioedema AE
Acousma AE is a sensory capability AE that shows a hallucinatory impression of strange sounds.
JX, LW, YH
幻听
acousma AE
Eye burning AE is a eye AE that shows a feeling of burning in the eye.
JX, LW, YH
眼睛灼烧感
eye burning AE
Worsening renal function AE is a kidney AE that shows worsening renal function.
JX, LW, YH
肾功能恶化
worsening renal function AE
Mild change of hematology AE is a change of hematology AE that shows mild change of hematology.
JX, LW, YH
轻度的血液学改变
mild change of hematology AE
Moderate change of hematology AE is a change of hematology AE that shows moderate change of hematology.
JX, LW, YH
中度的血液学改变
moderate change of hematology AE
Severe lower blood pressure AE is a hypotension AE that shows severe sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
JX, LW, YH
significantly decreased blood pressure AE
严重的血压降低
severe lower blood pressure AE
Elevated blood transaminase reversibility AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase reversibly.
JX, LW, YH
血氨基转移酶可逆性升高
elevated blood transaminase reversibility AE
Mild gastrointestinal tract reaction AE is a gastrointestinal disorder AE that shows a mild gastrointestinal disorder.
JX, LW, YH
轻度胃肠道反应
mild gastrointestinal tract reaction AE
Temporary abdominal distention AE is a abdominal distension AE that shows a temporary sensation of elevated abdominal pressure and volume.
JX, LW, YH
暂时性腹胀
temporary abdominal distention AE
Transient nausea AE is a nausea AE that is a gastric discomfort associated with the inclination to vomit.
JX, LW, YH
暂时性恶心
transient nausea AE
Persistent tachycardia AE is a tachycardia AE that is an increased heart rate that exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual). It's a constant process.
JX, LW, YH
持续心动过速
persistent tachycardia AE
Mild headache AE is a headache AE that shows mild headache.
JX, LW, YH
轻度头痛
mild headache AE
Transient hypoxemia AE is a hypoxia AE that is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases.
JX, LW, YH
瞬态低氧血症
transient hypoxemia AE
Transient neuroticism AE is a neuroticism AE that is a type of personality trait that contrasts adjustment or emotional stability with maladjustment. Experience of anxiety, anger, disgust, sadness, embarrassment, and a variety of other negative emotions.
JX, LW, YH
瞬态神经质
transient neuroticism AE
Constant irritability AE is a irritability AE that shows in the patient being easily annoyed/irritated constantly.
JX, LW, YH
持续烦躁
constant irritability AE
Abnormal atony AE is a asthenia AE that is a medical term denoting symptoms of physical weakness and loss of strength.
JX, LW, YH
异常无力
abnormal atony AE
Secondary hypotension AE is a hypotension AE that is a type of hypertension which by definition is caused by an identifiable underlying secondary cause.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Secondary_hypertension
继发性高血压
secondary hypotension AE
Transient elevated serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase transiently.
JX, LW, YH
瞬时血清转氨酶升高
transient elevated serum transaminase AE
Transient elevated blood urea nitrogen AE is a blood urea level increased AE that shows a transient increase in amount of urea in blood.
JX, LW, YH
瞬时血尿素氮升高
transient elevated blood urea nitrogen AE
Apparent increased blood creatine phosphokinase AE is a blood creatine phosphokinase level increased AE that is characterized by an apparent increased level of creatine phosphokinase or phosphocreatine kinase.
JX, LW, YH
明显的血肌酸磷酸激酶增高
apparent increased blood creatine phosphokinase AE
Severe rhabdomyolysis AE is a rhabdomyolysis AE that shows in severe damaged skeletal muscle tissue breaks down rapidly.
JX, LW, YH
严重的横纹肌溶解症
severe rhabdomyolysis AE
Mild gastrointestinal bleeding AE is a gastrointestinal hemorrhage AE that shows mild gastrointestinal hemorrhage.
JX, LW, YH
胃肠道轻微出血
mild gastrointestinal bleeding AE
Occult gastrointestinal tract bleeding AE is a gastrointestinal hemorrhage AE that shows occult gastrointestinal hemorrhage.
JX, LW, YH
胃肠道隐匿性出血
occult gastrointestinal tract bleeding AE
Nitrate headache AE is a headache AE that that is a special headache induced by nitrate.
JX, LW, YH
硝酸盐性头痛
nitrate headache AE
Pantomorphia erythema exudativum AE is a skin AE that is a skin condition of unknown cause, possibly mediated by deposition of immune complex (mostly IgM) in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure. It is an uncommon disorder, with peak incidence in the second and third decades of life.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Erythema_multiforme
多形性渗出性红斑
pantomorphia erythema exudativum AE
High hypodynamia AE is a fatigue AE that is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities.
JX, LW, YH
高度乏力
high hypodynamia AE
Short-time nausea AE is a nausea AE that shows a gastric discomfort associated with the inclination to vomit.
JX, LW, YH
短暂的恶心
short-time nausea AE
Slightly increased aspartic transaminase AE is a aspartate aminotransferase level increased AE that shows a slightly increased amount of AST which is an enzyme normally present in body tissues especially of the heart and liver,
JX, LW, YH
门冬氨酸氨基转移酶轻度升高
slightly increased aspartic transaminase AE
Slightly increased alanine aminotransferase AE is a alanine aminotransferase level increased AE that shows elevated levels of alanine transaminase slightly.
JX, LW, YH
丙氨酸氨基转移酶轻度升高
slightly increased alanine aminotransferase AE
Slightly increased lactic dehydrogenase AE is a blood lactate dehydrogenase level increased AE that shows a slightly increased amount of LDH which is an enzyme that could indicate tissue damage.
JX, LW, YH
乳酸脱氢酶轻度升高
slightly increased lactic dehydrogenase AE
Slightly increased alkaline phosphatase AE is a blood alkaline phosphatase increased AE that shows elevated levels of alkaline phosphatase slightly.
JX, LW, YH
碱性磷酸酶轻度升高
slightly increased alkaline phosphatase AE
Slightly increased glutamic-oxalacetic transaminase AE is a aspartate aminotransferase level increased AE that shows a slightly increased amount of glutamic-oxalacetic transaminase in the heart and liver.
JX, LW, YH
谷草转氨酶轻度升高
slightly increased glutamic-oxalacetic transaminase AE
Slightly increased glutamic pyruvic transaminase AE is a alanine aminotransferase level increased AE that shows eelevated levels of glutamic pyruvic transaminase in the liver.
JX, LW, YH
谷丙转氨酶轻度升高
slightly increased glutamic pyruvic transaminase AE
Transient ischemic stroke AE is a ischemic stroke AE that occurs when a blood vessel that supplies the brain becomes blocked or "clogged" and impairs blood flow to part of the brain.
JX, LW, YH
暂时性缺血性中风
transient ischemic stroke AE
Evidently increased hepatic lipase AE is a hepatic enzyme increased AE that shows an evidently increase in amount of hepatic enzyme in body, commonly includes ALT and AST. It may indicate inflammation or damage to liver cells.
JX, LW, YH
肝酶显著增加
evidently increased hepatic lipase AE
Mild decline in blood pressure AE is a hypotension AE that shows mild sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
JX, LW, YH
血压轻度下降
mild decline in blood pressure AE
Transient cerebral ischemic attacks AE is a cerebral ischemia AE that shows the sudden death of brain cells in a localized area due to inadequate blood flow.
JX, LW, YH
短暂脑缺血发作
transient cerebral ischemic attacks AE
Transient hypotension AE is a hypotension AE that shows transient sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
JX, LW, YH
瞬时低血压
transient hypotension AE
Obviously decreased blood pressure AE is a hypotension AE that shows obviously sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
JX, LW, YH
significantly decreased blood pressure AE
血压明显下降
obviously decreased blood pressure AE
Transient dizzy AE is a dizziness AE that shows transient dizziness.
JX, LW, YH
瞬时头晕
transient dizzy AE
Short-time hepatic function disorder AE is a hepatic function abnormal AE that shows a short-time abnormal functionality of the liver.
JX, LW, YH
短暂肝功能异常
short-time hepatic function disorder AE
A slightly elevated plasma creatinine level AE is a blood creatinine level increased AE that shows an slightly increased level of creatinine in the blood (due to lack of kidney activity).
JX, LW, YH
血浆肌酐水平的轻微升高
a slightly elevated plasma creatinine level AE
Sudden fall of blood pressure AE is a hypotension AE that shows sudden sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
JX, LW, YH
血压突然降低
sudden fall of blood pressure AE
Severe hypertension AE is a hypotension AE that shows severe sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
JX, LW, YH
严重高血压
severe hypertension AE
Severe arrhythmia AE is an arrhythmia AE that shows severe abnormal heart rhythm.
JX, LW, YH
严重心律失常
severe arrhythmia AE
Clinically significant rise of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly.
JX, LW, YH
血清转氨酶有临床显著升高
clinically significant rise of serum transaminase AE
Instantaneous sand-blind AE is a vision blurred AE that shows in instantaneous unclear vision.
JX, LW, YH
瞬时视觉模糊
instantaneous sand-blind AE
Moderately increased urinary nitrogen AE is a blood urea level increased AE that shows a moderately increase in amount of urea in blood.
JX, LW, YH
尿素中度升高
moderately increased urinary nitrogen AE
Slightly increased urinary nitrogen AE is a blood urea level increased AE that shows a slightly increase in amount of urea in blood.
JX, LW, YH
尿素水平轻微升高
slightly increased urinary nitrogen AE
Moderately elevated serum creatinine AE is a blood creatinine level increased AE that shows an moderately increased level of creatinine in the blood (due to lack of kidney activity).
JX, LW, YH
血肌酐中度升高
moderately elevated serum creatinine AE
Slightly increased aminotransferase AE is a transaminase level increased AE that shows slightly elevated levels of alanine transaminase and aspartate transaminase.
JX, LW, YH
轻度氨基转氨酶升高
slightly increased aminotransferase AE
Severe dizziness AE is a dizziness AE that shows severe dizziness.
JX, LW, YH
严重眩晕
severe dizziness AE
Mild abdominal discomfort AE is a abdominal discomfort AE that shows a mild stomach ache.
JX, LW, YH
轻微腹部不适
mild abdominal discomfort AE
A blood potassium decreased quality where the amount of potassium in the blood is moderately decreased.
JX, LW, YH, MW
血清钾浓度的轻度降低
serum potassium concentration of moderately reduced
Rebound Increased blood pressure AE is a hypertension AE that shows rebound sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
JX, LW, YH
反跳性血压升高
rebound Increased blood pressure AE
Excessive lowering of blood pressure AE is a hypotension AE that shows excessive sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
JX, LW, YH
血压过度降低
excessive lowering of blood pressure AE
Short-time increased blood sugar AE is a blood glucose level increased AE that shows a short-time increased glucose level in blood.
JX, LW, YH
短暂血糖升高
short-time increased blood sugar AE
Mild nausea AE is a nausea AE that shows mild nausea.
JX, LW, YH
轻度恶心
mild nausea AE
Significant and persistent rise of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly and persistently.
JX, LW, YH
血清氨基转移酶显著和持续性升高
significant and persistent rise of serum transaminase AE
Elevated serum transaminase reversibility AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase reversibly.
JX, LW, YH
血清氨基转移酶可逆性升高
elevated serum transaminase reversibility AE
Reversible increased creatine phosphokinase AE is a blood creatine phosphokinase level increased AE that is characterized by an reversible increased level of creatine phosphokinase or phosphocreatine kinase.
JX, LW, YH
肌酸磷酸激酶可逆性升高
reversible increased creatine phosphokinase AE
Persistent and significant increase of serum transaminase AE is a transaminase level increased AE that shows elevated levels of alanine transaminase and aspartate transaminase significantly and persistently.
JX, LW, YH
血清转氨酶显著和持续性升高
persistent and significant increase of serum transaminase AE
Severe bradycardia AE is a bradycardia AE that shows in a resting heart rate of under 60 beats per minutes (BPM).
JX, LW, YH
严重心动过缓
severe bradycardia AE
Apparent hypotensive reaction AE is a hypotension AE that shows apparent sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states.
JX, LW, YH
显著的低血压反应
apparent hypotensive reaction AE
Severe skin flush AE is a hot flush AE that shows severe hot flush.
JX, LW, YH
显著皮肤潮红
severe skin flush AE
Transient sinus cardiac arrest AE is a sinus arrest AE that shows an electrocardiographic finding of transient impulse formation failure in the sinus node.
JX, LW, YH
瞬时窦性停搏
transient sinus cardiac arrest AE
Low-grade gastralgia AE is a stomacheache AE that shows a low-grade painful sensation in the stomach.
JX, LW, YH
轻度胃痛
low-grade gastralgia AE
Severe headache AE is a headache AE that shows severe headache.
JX, LW, YH
严重头痛
severe headache AE
Persistent headache AE is a headache AE that shows persistent headache.
JX, LW, YH
持续头痛
persistent headache AE
Proarrhythmic effect AE is an arrhythmia AE that is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications. In other words, it is a tendency of antiarrhythmic drugs to facilitate emergence of new arrhythmias.
JX, LW, YH
arhythmia auxo-action AE
WEB: http://en.wikipedia.org/wiki/Proarrhythmia
致心律失常
10036766
proarrhythmic effect AE
a metabolism, endocrine, and exocrine system AE that has an outcome of acidosis, i.e., too much acid in the body fluids.
Blood pH Decreased
URL: http://www.nlm.nih.gov/medlineplus/ency/article/001181.htm
10000486
10005706
YH, SJ, MW
acidosis AE
CTCAE:E12237
NCIt:C28228
Increased tendency of biliary calculus AE is a liver, biliary, and pancreatic AE that shows an increased tendency of biliary calculus.
JX, LW, YH
胆石增加的趋势
increased tendency of biliary calculus AE
Temporarily lose consciousness AE is a sensory capability AE that shows temporarily lose consciousness.
JX, LW, YH
暂时失去知觉
temporarily lose consciousness AE
Increase breast cancer occurrence AE is a breast cancer AE that shows increase breast cancer occurrence.
JX, LW, YH
乳腺癌发生增加
increase breast cancer occurrence AE
Anticholinergic effect AE is a conduction system disorder AE that is physical symptoms resulting from agents that counter the action of acetylcholine, a neurotransmitter (chemical within the nervous system) that is involved in many major bodily functions. These anticholinergic effects typically include constipation, dry mouth, blurred vision, dizziness, and slowing of urination.
JX, LW, YH
WEB: http://ibs.about.com/od/glossary/g/Anticholeffect.htm
经讯号传导阻断效应
anticholinergic effect AE
a musculoskeletal system AE that has an outcome of diaphragmatic muscle replaced by fibroelestic tissue. The diaphragm retains its continuity and attachments to the costal margin. However, the weakened hemidiaphragm is displaced into the thorax, which can compromise breathing.
SJ, YH
URL: http://www.uptodate.com/contents/eventration-of-the-diaphragm-in-infants
10000486
acquired diaphragmatic eventration AE
Neutrophilopenia AE is a neutrophil count decreased AE that shows the number of neutrophil is decreased.
JX, LW, YH
中性白细胞减少
neutrophilopenia AE
Abnormal leucocyte neutrophil AE is a neutrophil percentage abnormal AE that shows abnormal leucocyte neutrophil.
JX, LW, YH
嗜中性白细胞异常
abnormal leucocyte neutrophil AE
Abnormal eosinocyte AE is an eosinophil count abnormal AE that shows abnormal eosinocyte.
JX, LW, YH
嗜酸性粒细胞异常
abnormal eosinocyte AE
Eosinopenia AE is an eosinophil count abnormal AE that is a form of agranulocytosis where the number of eosinophil granulocytes is lower than expected.
JX, LW, YH
WEB: http://en.wikipedia.org/wiki/Eosinopenia
嗜酸细胞减少症
10014940
eosinopenia AE
Aggravated peptic ulcer AE is a duodenal ulcer AE that shows aggravated peptic ulcer.
JX, LW, YH
消化性溃疡加重
aggravated peptic ulcer AE
Local tissue necrosis AE is a necrosis AE that shows local tissue necrosis.
JX, LW, YH
局部组织坏死
local tissue necrosis AE
a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by diminished blood supply to the heart
SJ, YH
URL: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/cardiology/acute-myocardial-infarction/
10000891
acute myocardial infarction AE
an endocrine system AE that results in a life threatening condition due to a lack of cortisol produced by the adrenal glands
SJ, YH
URL: http://www.nlm.nih.gov/medlineplus/ency/article/000357.htm
10001389
acute adrenal crisis AE
YH, SJ
URL http://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2814%2970102-4/abstract
10053552
a pain AE that results in pain from a stimulus that does not usually provoke pain
allodynia AE
an embolism AE in which amniotic fluid, fetal cells, hair or other debris enter the maternal circulation resulting in cardiorespiratory collapse
SJ, YH
Anaphylactoid Syndrome of Pregnancy
WEB: http://emedicine.medscape.com/article/253068-overview
10001977
amniotic fluid embolism AE
a muscular weakness AE that has an outcome of weakness followed by wasting of muscles, and excruciating pain in the muscles of the thigh, hip, and buttocks
YH, SJ
diabetic lumbosacral radiculoplexus neuropathy
diabetic polyradiculoneuropathy
proximal diabetic neuropathy
10002027
diabetic amyotrophy AE
an adverse drug event that results in unexpected and unwanted events due to anesthetic drug treatment
SJ, YH
WEB: https://www.dha.gov.ae/EN/Facilities/Hospitals/RashidHospital/SpecializedMedicalService/ClinicalServices/Anesthesiologyandinterventionalpain/pages/sideeffects.aspx
10060938
anesthetic complication AE
an anus AE that results in the development of a small channel between the end of the bowel and the skin near the anus
SJ, YH
WEB: http://www.webmd.boots.com/digestive-disorders/anal-fistula
10002156
anal fistula AE
CTCAE: E10464
NCIt: C60785
postoperative anemia AE is an anemia AE that occurs when a patient with acute bleeding loses enough blood to become anemic
SJ, YH
bleeding and acute blood loss anemia
WEB: http://www.acphospitalist.org/archives/2012/02/coding.htm
10054312
postoperative anemia AE
a behavior and neurological AE that results in antagonism toward someone or something you feel has deliberately done you wrong: excessive anger can cause problems including increased blood pressure and other physical changes that make it difficult to think straight and can harm your physical and mental health.
SJ, YH
WEB: http://apa.org/topics/anger/index.aspx
10002368
anger AE
a musculoskeletal system AE that results in the formation of fibrous band between tissues and organs, often as a result of injury during surgery
SJ, YH
URL: http://en.wikipedia.org/wiki/Adhesion_%28medicine%29
10059837
adhesion AE
a crying abnormal AE that refers to a neurologic disorder characterized by involuntary crying or uncontrollable episodes of crying and/or laughing, or other emotional displays
YH, SJ
emotional incontinence
emotional lability
labile affect
WEB: http://en.wikipedia.org/wiki/Pseudobulbar_affect
10054196
pseudobulbar affect AE
cardiovascular AE that results in disease of the arteries, veins, and capillaries
SJ, YH
macroangiopathy
microangiopathy
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853
10059245
angiopathy AE
a cardiovascular AE that results in the walls of small blood vessels becoming so thick and weak that they bleed, leak protein, and slow the flow of blood
SJ, YH
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853
10062198
microangiopathy AE
a cardiovascualr AE that results in the build up of fat and blood clots in the large blood vessels, stick to the vessel walls, and block the flow of blood
SJ, YH
cerebrovascular disease
coronary artery disease
peripheral vascular disease
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=6853
10054805
macroangiopathy AE
a muscle AE that results in a congenital anomaly in which a short, lingual frenulum or a highly-attached genioglossus muscle restricts tongue movement
SJ, YH
tongue-tie
WEB: http://www.uptodate.com/contents/ankyloglossia-tongue-tie-in-infants-and-children
10049244
ankyloglossia AE
a digestive system AE that results in a group of medical disorders that occur at the junction of the anal canal and the rectum
SJ, YH
WEB: http://medical-dictionary.thefreedictionary.com/Anorectal+Disorders
10002644
anorectal disorder AE
a hemorrhage AE that has an outcome of bleeding from or in to the genital tract, occurring from 24 weeks of pregnancy and prior to the birth of the baby.
YH, SJ
WEB: https://www.rcog.org.uk/globalassets/documents/guidelines/gtg63_05122011aph.pdf
10055228
antepartum hemorrhage AE
Brain damage AE that results in a persistent vegetative state
SJ, YH
WEB: http://www.rightdiagnosis.com/a/apallic_syndrome/intro.htm
10002941
apallic syndrome AE
APGAR is a quick test performed on a neonate at 1 and 5 minutes after birth. The 1-minute score determines how well the baby tolerated the birthing process. The 5-minute score tells the doctor how well the baby is doing outside the mother's womb. Any score lower than 7 is a sign that the baby needs medical attention. The lower the score, the more help the baby needs to adjusting outside the mother's womb
YH, SJ
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003402.htm
10002944
10062552
APGAR score low AE
a brain disorder AE that causes a person to lose the ability to communicate. Aphasia can affect the ability to express and understand language, both verbal and written. Aphasia typically occurs suddenly after a stroke or a head injury, but it can also come on gradually from a slowly growing brain tumor or a degenerative disease
SJ, YH
WEB: http://www.mayoclinic.org/diseases-conditions/aphasia/basics/definition/con-20027061
10002948
aphasia AE
a tumor AE that results in pouches of cerebrospinal fluid covered by arachnoidal cells and collagen that may develop between the surface of the brain and the cranial base or on the arachnoid membrane
SJ, YH
WEB:http://en.wikipedia.org/wiki/Arachnoid_cyst
10049005
arachnoid cyst AE
a brain disorder AE that causes inflammation of the arachnoid, one of the membranes known as meninges that surround and protect the nerves of the central nervous system, including the brain and spinal cord.
SJ, YH, MW
WEB: http://en.wikipedia.org/wiki/Arachnoiditis
10003074
arachnoiditis AE
CTCAE:E12591
NCIt:C37913
A pregnancy AE that results in an interruption in the labor process that is associated with uterine contractions.
SJ, YH
WEB: http://medical-dictionary.thefreedictionary.com/arrested+labor
10003118
arrested labor AE
an arrhythmia AE that is characterized by shortness of breath, heart palpitations, chest tightness, and a very fast pulse. Supraventricular arrhythmias begin in the areas above the heart’s lower chambers, such as the upper chambers (the atria) or the atrial conduction pathways.
SJ, YH
atrial arrhythmia
WEB: http://www.texasheart.org/HIC/Topics/cond/arrhycat.cfm
10003130
supraventricular arrhythmia AE
a cardiac disorder AE which causes a spasm of the large- or medium-sized coronary arteries
SJ, YH
coronary artery spasm
coronary artery vasospasm
coronary vasospasm
WEB: http://sideeffects.embl.de/se/C0010073/pt
10003225
coronary arteriospasm AE
joint range of motion decreased AE caused by an excessive amount of scar tissue forming within the joint and surrounding soft tissue spaces
SJ, YH
WEB: http://en.wikipedia.org/wiki/Arthrofibrosis
10058029
arthrofibrosis AE
arteriosclerosis AE is a cardiovascular AE that results in blood vessels and arteries becoming thick and stiff which can restrict blood flow to organs and tissues.
SJ, YH
WEB: http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972
10003210
arteriosclerosis AE
atheroslcerosis AE is a specific arteriosclerosis AE that refers to the buildup of fats, cholesterol and other substances in and on artery walls which can restrict blood flow.
SJ, YH
WEB: http://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/basics/definition/con-20026972
10003601
atherosclerosis AE
atrial tachycardia AE is a tachycardia AE that results in a fast heart rate beginning in the upper chambers of the heart
SJ, YH
paroxysmal atrial tachycardia
paroxysmal supraventricular tachycardia
supraventricular tachycardia
WEB: http://www.heart.org/HEARTORG/Conditions/Arrhythmia/AboutArrhythmia/Tachycardia-Fast-Heart-Rate_UCM_302018_Article.jsp#
10003668
10034040
atrial tachycardia AE
CTCAE: E10166
NCIt: C34900
a hematology investigation result abnormal AE that results in high blood cortisol levels
SJ, YH
URL: http://www.nlm.nih.gov/medlineplus/ency/article/003693.htm
10005458
blood cortisol decreased AE may indicate that the patient has cushing disease, ectopic cushing syndrome, or a tumor of the adrenal gland that is producing too much cortisol.
blood cortisol increased AE
a cardiovascular disorder AE that results in easy or excessive bruising and bleeding. The bleeding results from unusually low levels of platelets.
SJ, YH
immune thrombocytopenic purpura
WEB: http://www.mayoclinic.org/diseases-conditions/idiopathic-thrombocytopenic-purpura/basics/definition/con-20034239
10050245
idiopathic thrombocytopenic purpura AE
YH, SJ
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2477
10005063
a pain AE that is observed in the bladder, usually a symptom of bladder infection.
bladder pain AE
an eye AE that results in involuntary, forcible closure of the eyelids.The spasms may leave the eyelids completely closed, causing functional blindness even though the eyes and vision are normal.
SJ, YH
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2481
10005159
blepharospasm AE
an abnormal vision AE which has an outcome of loss of vision in one eye that is not permanent.
SJ, YH
blindness unilateral
WEB: http://en.wikipedia.org/wiki/Amaurosis_fugax
10005186
amaurosis fugax AE
a hematology investigation result abnormal AE that results in low blood cortisol levels
SJ, YH
URL: http://www.nlm.nih.gov/medlineplus/ency/article/003693.htm
10005457
blood cortisol decreased AE may indicate that the patient has addison disease, hypopituitarism, suppression of normal pituitary or adrenal function.
blood cortisol decreased AE
a hematology investigation result abnormal AE that results in high blood creatine levels
SJ, YH
URL: http://www.mayoclinic.org/tests-procedures/creatinine/basics/definition/prc-20014534
10005464
blood creatine increased AE may indicate that the kidneys are not fucntioning properly
blood creatine increased AE
a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly
YH, SJ
10005971
bone graft procedure
a hematology investigation result abnormal AE that signifies that a patient is allergic to a particular substance
SJ, YH
WEB: http://kidshealth.org/parent/system/medical/test_ige.html
10005591
blood immunoglobin E increased AE
a hematology investigation result abnormal AE that results in low levels of testosterone which can lead to infertility and a low sex drive
SJ, YH
WEB: http://www.webmd.com/men/testosterone-15738
10005814
blood testosterone decreased AE
A macrocytic anemia AE is an anemia AE that has an outcome of a macrocytic anemia, which is an anemia (defined as blood with an insufficient concentration of hemoglobin) in which the red blood cells (erythrocytes) are larger than their normal volume.
KM, YH
WEB: http://en.wikipedia.org/wiki/Macrocytic_anemia
10002064
macrocytic anemia AE
a bone disorder AE that has an outcome of low bone densityl, but not low enough to be considered osteoporosis
SJ, YH
WEB: http://nof.org/articles/9
10049470
low bone density AE
a surgical AE that occurs after a bone graftr procedure, which replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly.
SJ, YH
WEB: http://en.wikipedia.org/wiki/Bone_grafting
bone graft AE
bone marrow edema AE is an edema AE that occurs when excess fluids in the bone marrow buildup and cause swelling. This condition is often caused by a protective reaction of the body in response to an injury or inflammation
SJ, YH
WEB: http://www.wisegeek.com/what-is-bone-marrow-edema.htm
10051763
bone marrow edema AE
an investigation result abnormal AE that detects areas of increased or decreased bone activity. These may indicate bone injury or disease.
SJ, YH
WEB: http://www.mountsinai.org/patient-care/health-library/treatments-and-procedures/bone-scan
10061941
bone scan abnormal AE
Nervous system AE that covers a variety of conditions that may impair function of the brachial plexus nerve network, most of which are caused by trauma.
SJ, YH
WEB: http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/peripheral_nerve_surgery/conditions/brachial_plexus_injury_bpi.html
10006074
brachial plexus injury AE
a bradycardia AE that results in a disturbance in the heart rhythm in which the heart rate is abnormally slowed.
SJ, YH
WEB: http://medical-dictionary.thefreedictionary.com/bradyarrhythmia
10049765
bradyarrhythmia AE
a bradycardia AE that results in a fetal heart rate of less than 120 beats per minute, generally associatedwith hypoxia
SJ, YH
WEB:http://medical-dictionary.thefreedictionary.com/fetal+bradycardia
10006094
bradycardia fetal AE
a brain disorder AE that results in the complete and irreversible loss of brain function
SJ, YH
WEB: http://en.wikipedia.org/wiki/Brain_death
10049054
brain death AE
a brain disorder AE that results in brain tissue, cerebrospinal fluid, and blood vessels being moved or pressed away from their usual position inside the skull.
SJ, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001421.htm
10006126
brain herniation AE
a brain injury AE, injury to the brain caused by an external force, that results in a brain AE
SJ, YH
Traumatic Brain Injury
WEB: http://www.biausa.org/FAQRetrieve.aspx?ID=43913
10067967
brain injury AE
a brain mass AE is a mass or growth of abnormal cells in your brain or close to your brain
SJ, YH
Brain Neoplasm
Brain Tumor
Intercranial Neosplasm
WEB: http://www.mayoclinic.org/diseases-conditions/brain-tumor/home/ovc-20117132
10052334
10061019
brain mass AE
an imaging investigation result abnormal AE shows how the brain and its tissues are working. Abnormal results may be due to: Alzheimer’s disease or dementia, brain tumors, epilepsy, and movement disorders.
SJ, YH
PET scan
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007341.htm
10061943
brain scan abnormal AE
Eyelid disorder AE is a eye AE that is a condition specifically affects the eyelid. It can include drooping, twitching, inflammation, paralysis, and growths. Occasional fluttering of one eyelid is normal.
JX, LW
WEB: http://www.healthline.com/health/eyelid-disorders#Overview1
10061130
eyelid disorder AE
Hepatic steatosis AE is a liver disorder AE than popularly called as ‘fatty liver’ is a pathological aspect of liver, whose specific cells (hepatocytes) are filled with lipids (fats). It is a reversible liver disease: ‘is not still very ill, but cries for help’.
JX, LW
WEB: http://www.bendomd.com/272-hepatic-steatosis-causes-symptoms-treatment.html
10019708
hepatic steatosis AE
An arthropathy AE is a joint pain AE that has an outcome of arthropahty, which is any disorder of the joints.
KM, YH
WEB: http://en.wikipedia.org/wiki/Arthropathy, http://medical-dictionary.thefreedictionary.com/arthropathy
10003285
arthropathy AE
NCIT: C35760
A balantis AE is a reproductive system AE that has an outcome of a balantis, which is an infectious or non-infectious inflammatory process that affects the glans penis. Symptoms include redness and pain of the glans penis and foreskin and discharge.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000862.htm, http://en.wikipedia.org/wiki/Balanitis
10004073
balanitis AE
Pruritus genital AE is a pruritus AE that also called genital itching, Itching in the genital region can result from irritation, allergy, inflammation, infection or cancer. Irritation can occur as a result of exposure to chemicals in soaps, feminine hygiene products, perfumes, lubricants, douches, and creams.
JX, LW
genital itching AE
WEB: http://www.healthgrades.com/symptoms/genital-itching
10037093
pruritus genital AE
cholecystitis AE is an gallbladder enlargement AE that has an outcome of cholecystitis, which is an acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones.
KM, YH
WEB: http://en.wikipedia.org/wiki/Cholecystitis, http://www.mayoclinic.org/diseases-conditions/cholecystitis/basics/definition/con-20034277
10008612
cholecystitis AE
CTCAE: E11184
NCIT: C34465
NCIt: C34465
Chromaturia AE is an urine abnormality AE that has an outcome of chromaturia, which is an abnormal coloration of the urine.
KM, YH
WEB: http://medical-dictionary.thefreedictionary.com/chromaturia
10008796
chromaturia AE
Chromosome abnormality AE is a genetic AE that has an outcome of chromsome abnormality which is a missing, extra, or irregular protion of chromosomal DNA.
KM, YH
WEB: http://en.wikipedia.org/wiki/Chromosome_abnormality
10008815
chromosome abnormality AE
A coagulopathy AE is a blood disorder AE that has an outcome of coagulopathy, which is a condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
KM, YH
WEB: http://en.wikipedia.org/wiki/Coagulopathy
10009802
coagulopathy AE
Combined immunodeficiency AE is an immune system AE that has an outcome of combined immunodeficiency, which represents a group of rare, sometimes fatal, congenital disorders characterized by little or no immune response.
KM, YH
WEB: http://www.ncbi.nlm.nih.gov/books/NBK22254/
10010099
combined immunodeficiency AE
Hepatic enzyme abnormal AE is a liver related investigation result abnormal AE that the lab test result of hepatic enzyme deviates from its normal value.
JX, YH
10062685
hepatic enzyme abnormal AE
A coronary artery aneurysm AE is a coronary artery disorder AE that has an outcome of coronary artery aneurysm, which is a coronary dilatation which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times.
KM, YH
WEB: http://en.wikipedia.org/wiki/Coronary_artery_aneurysm
WEB: http://www.ncbi.nlm.nih.gov/pubmed/9247557
10011071
coronary artery aneurysm AE
Injection site atrophy AE is an injection-site AE that muscle atrophy occur in the injection site.
JX, YH
10022048
injection site atrophy AE
A cutaneous tuberculosis AE is a tuberculosis AE that has an outcome of cutaneous tuberculosis, which is an invasion of the skin by Mycobacterium tuberculosis.
KM, YH
WEB: http://www.dermnetnz.org/bacterial/tuberculosis.html
10011684
cutaneous tuberculosis AE
Breath sounds abnormal AE is a respiratory system AE that is characterized by abnormal breath sound, it can indicate fluid in the lungs or asthma.
JX, LW
WEB: http://www.healthline.com/health/breath-sounds#Overview1
10064780
breath sounds abnormal AE
Skin abrasion AE is a skin AE that is a wound caused by superficial damage to the skin, no deeper than the epidermis.
JX, YH
WEB: http://en.wikipedia.org/wiki/Abrasion_%28medical%29
10064990
skin abrasion AE
Trigeminal neuralgia AE is a neuralgia AE that is a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. The clinical association between TN and hemifacial spasm is the so-called tic douloureux.
JX, YH
Fothergill's disease AE
prosopalgia AE
WEB: http://en.wikipedia.org/wiki/Trigeminal_neuralgia
10044652
trigeminal neuralgia AE
Face injury AE is an injury AE that injury occurs in the face.
JX, YH
10050392
face injury AE
Muscle contrature AE is a muscle AE that can occur for many reasons, such as paralysis, muscular atrophy, and forms of muscular dystrophy. Fundamentally, the muscle and its tendons shorten, resulting in reduced flexibility.
JX, YH
WEB: http://en.wikipedia.org/wiki/Muscle_contracture
10062575
muscle contrature AE
Gaze palsy AE is a behavior and neurological AE that is a symmetric limitation of the movements of both eyes in the same direction.
JX, YH
WEB: http://one.aao.org/bcscsnippetdetail.aspx?id=f5a77965-de2a-4fb0-82fb-5f4089671ad6
10056696
gaze palsy AE
Conjugate gaze palsy AE is a gaze palsy AE that is a disorder affecting the ability to move both eyes in the same direction. These palsies can affect gaze in a horizontal, upward, or downward direction.
JX, YH
WEB: http://en.wikipedia.org/wiki/Conjugate_gaze_palsy
conjugate gaze palsy AE
Horizontal gaze palsy AE is a gaze palsy AE that is the paresis of conjugate eye movements.
JX, YH
WEB: http://en.wikipedia.org/wiki/Horizontal_gaze_palsy
horizontal gaze palsy AE
a behavioral and neurological AE that refers to rigid body movements and chronic abnormal positions of the body. This symptom is not the same as showing poor posture or slumping over. Rather, it is often the result of a serious spinal cord or brain injury.
JX, YH
WEB: http://www.healthline.com/symptom/posture-abnormal
10036436
posture abnormal AE
a behavioral and neurological AE that shows the body becomes entire rigid and uncontrolled jerking. They may last mere seconds, or continue for several minutes.
JX, YH
10051171
tonic clonic movements AE
Eyelid ptosis AE is an eye disorder AE that is a drooping or falling of the upper or lower eyelid.
JX, LW
WEB: http://en.wikipedia.org/wiki/Ptosis_%28eyelid%29
10015995
eyelid ptosis AE
Facial paresis AE is a paresis AE that is a common problem that involves the paralysis of any structures innervated by the facial nerve.
JX, YH
facial nerve paralysis AE
WEB: http://en.wikipedia.org/wiki/Facial_nerve_paralysis
10051267
facial paresis AE
Menstrual disorder AE is an abnormal condition in a woman's menstrual cycle.
WEB: http://en.wikipedia.org/wiki/Menstrual_disorder
10027327
JX, YH
menstrual disorder AE
Fluid retention AE is an abnormal fluid regulation AE that is excess fluid that collects in the tissues in your body. Most commonly, fluid retention is marked by swelling of your feet and lower legs, but swelling could also occur in your arms, hands, face, or other areas of the body.
JX, YH
WEB: http://www.healthgrades.com/symptoms/fluid-retention
10016807
fluid retention AE
Emotional distress AE is a emotional disorder AE that is a Mental distress or anxiety suffered as a response to a sudden, severe, and saddening experience.
JX, YH
WEB: http://en.wikipedia.org/wiki/Emotional_distress
10049119
emotional distress AE
Encephalitis AE is a nervous system AE that is an acute inflammation of the brain.
JX, YH
WEB: http://en.wikipedia.org/wiki/Encephalitis
10014581
encephalitis AE
a psychiatric disorder AE that is a category of mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium.
JX, YH
WEB: http://en.wikipedia.org/wiki/Cognitive_disorder
10057668
cognitive disorder AE
Incoherent AE is a speech disorder AE that shows unable to express one's thoughts or ideas in an orderly, intelligible manner.
JX, YH
WEB: http://medical-dictionary.thefreedictionary.com/incoherent
10021630
incoherent AE
Exercise tolerance decreased AE is a systematic AE that shows exercise tolerance decreased. The exercise tolerance refers to the exercise capacity of an individual as measured by their ability to endure exercise and/or the maximum work load achieved during the exercise period.
JX, YH
WEB: http://copd.about.com/od/glossaryofcopdterms/g/activitytoleran.htm
10051301
exercise tolerance decreased AE
a burn AE that is a type of burn resulted from making contact with heated objects, such as boiling water, steam, hot cooking oil, fire, and hot objects.
JX, LW
WEB: http://en.wikipedia.org/wiki/Thermal_burn
10053615
thermal burn AE
a psychiatric disorder AE that describes a wide array of experiences from mild detachment from immediate surroundings to more severe detachment from physical and emotional experience.
JX, YH
WEB: http://en.wikipedia.org/wiki/Dissociation_%28psychology%29
10013457
dissociation AE
Acupuncture is the stimulation of specific acupuncture points along the skin of the body using thin needles. It can be associated with the application of heat, pressure, or laser light to these same points.
JX, LW
WEB: http://en.wikipedia.org/wiki/Acupuncture
10000646
acupuncture
Mucous membrane disorder AE is a systematic AE that the diseases occur in mucous membrane, which is a lining of mostly endodermal origin.
JX, YH
WEB: http://en.wikipedia.org/wiki/Mucous_membrane
10028133
mucous membrane disorder AE
a polyneuropathy AE that arises when the myelin sheaths around nerve cells are damaged. Myelin, the insulating layer of tissue that surrounds nerve cells, helps ensure that signals from the brain are rapidly transmitted to the proper places in the body. When myelin is damaged or destroyed, it can lead to problems with communication between the brain and the body.
JX, YH
WEB: http://www.healthgrades.com/conditions/chronic-inflammatory-demyelinating-polyneuropathy
10061811
demyelinating polyneuropathy AE
a syndrome AE that results in increased pressure in a muscle compartment which can lead to nerve damage and impaired blood flow.
SJ, YH
URL: http://www.nlm.nih.gov/medlineplus/ency/article/001224.htm
10010121
Thick layers of tissue, called fascia, separate groups of muscles in the arms and legs from each other. Inside each layer of fascia is a confined space, called a compartment. The compartment includes the muscle tissue, nerves, and blood vessels.
compartment syndrome AE
Therapeutic response decreased is found among people who take Cialis, especially for people who are male, 60+ old, have been taking the drug for < 1 month, also take medication Aspirin, and have Erection problems.
JX, LW
WEB: http://www.ehealthme.com/ds/cialis/therapeutic+response+decreased
10043414
therapeutic response decreased
Bed rest is a medical treatment in which a person lies in bed for most of some period of time to gain health benefits.
JX, LW
WEB: http://en.wikipedia.org/wiki/Bed_rest
10050118
bed rest
a seizure AE that resutls in impariment of awareness and involuntary but coordinated and repeated movements.
YH, SJ
WEB: http://www.webmd.com/epilepsy/guide/types-of-seizures-their-symptoms?page=2
10010145
complex partial seizure AE
Autoimmune disorder AE is an immune system AE that arises from an abnormal immune response of the body against substances and tissues normally present in the body (autoimmunity).
JX, YH
WEB: http://en.wikipedia.org/wiki/Autoimmune_disease
10061664
autoimmune disorder AE
CTCAE: E11258
NCIt: C2889
a hemorrhage AE that has an outcome of bleeding into the pons or mesencephalon.
SJ, YH
WEB: http://medical-dictionary.thefreedictionary.com/brainstem+hemorrhage
10006146
brain stem hemorrhage AE is often secondary to brainstem distortion due to rapidly expanding intracranail lessions.
brainstem hemorrhage AE
Menstruation irregular AE is a endocrine system AE that is an abnormal variation in length of menstrual cycles in a female.
JX, YH, MW
irregular menstruation AE
WEB: http://en.wikipedia.org/wiki/Irregular_menstruation
10022992
10027339
menstruation irregular AE
CTCAE: E13125
NCIt: C35219
Generalised tonic-clonic seizure AE is a seizure AE that is a type of generalized seizure that affects the entire brain. Tonic–clonic seizures are the seizure type most commonly associated with epilepsy and seizures in general, though it is a misconception that they are the only type.
JX, YH
WEB: http://en.wikipedia.org/wiki/Tonic%E2%80%93clonic_seizure
10018100
generalised tonic-clonic seizure AE
a psychiatric disorder AE that an involuntary flexion or extension of the arms and legs, indicating severe brain injury.
JX, YH
WEB: http://en.wikipedia.org/wiki/Abnormal_posturing
10036437
posturing AE
Off label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, unapproved dosage, or unapproved form of administration.
JX, LW
off label use
WEB: http://en.wikipedia.org/wiki/Off-label_use
10053762
off label drug use
Demyelination AE is a nervous system AE that is any disease of the nervous system in which the myelin sheath of neurons is damaged.
JX, YH
WEB: http://en.wikipedia.org/wiki/Demyelinating_disease
10012305
demyelination AE
Gram stain negative AE is a microbiology and serology investigation result abnormal AE that has an outcome of detection of gram-negative bacteria.
JX, YH
WEB: http://en.wikipedia.org/wiki/Gram-negative_bacteria
10018656
gram stain negative AE
Red blood cells CSF positive AE is a CSF test result abnormal AE that has an outcome of CSF red blood cells count positive.
JX, YH
10038173
red blood cells CSF positive AE
CSF white blood cell count increased AE is a CSF test result abnormal AE that has an outcome of CSF white blood cell count increased.
JX, YH
10053805
CSF white blood cell count increased AE
Influenza A virus test positive AE is a influenza virus test positive AE that has an outcome of positive result in an influenza A virus test.
JX, YH
10070215
influenza A virus test positive AE
a behavior and neurological test abnormal AE that shows a abnormal result of nerve conduction study (NCS). NCS is a medical diagnostic test commonly used to evaluate the function, especially the ability of electrical conduction, of the motor and sensory nerves of the human body.
JX, YH
WEB: http://en.wikipedia.org/wiki/Nerve_conduction_study
10029175
nerve conduction study abnormal AE
Myocardial necrosis AE is a cardiac disorder AE that shows death of the cells of an area of the heart muscle (myocardium) as a result of oxygen deprivation, which in turn is caused by obstruction of the blood supply.
JX, YH
URL: http://medical-dictionary.thefreedictionary.com/myocardial+necrosis
10028602
myocardial necrosis AE
a brainstem infarction AE is a stroke AE that occurs when blood cannot flow to the brainstem, when oxygen cannot get to an area of the brain, tissue in that area may be damaged.
SJ, YH
brainstem stroke
WEB: http://en.wikipedia.org/wiki/Brain_stem_stroke_syndrome
WEB: http://www.drugs.com/cg/brain-stem-infarction.html
10006147
A person may have vertigo, dizziness and severe imbalance without the hallmark of most strokes – weakness on one side of the body. But dizziness alone is not a sign of stroke. Brain stem stroke can also cause diplopia, slurred speech and decreased level of consciousness.
brainstem infarction AE
a lung disorder AE that occurs when the noises produced by the structures of the lungs during breathing are decreased or absent.
SJ, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007535.htm
10006333
Absent or decreased breath sounds can indicate air or fluid around the lungs, increased thickness of chest wall, over-inflation of part of the lungs, or reduced airflow to part of the lungs.
breath sounds decreased AE
a syndrome AE that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death.
SJ, YH
sudden adult death syndrome (SADS)
WEB: http://en.wikipedia.org/wiki/Brugada_syndrome
10059027
Brugada syndrome AE
Buttock pain AE is a pain AE that is a common problem in the butt, it can be due to bursitis, bruising, piriformis syndrome, and shingles,or due to more serious diseases with long-term consequences, such as cancer, arthritis of the sacroiliac joints, and herniated disc with sciatica.
SJ, YH, MW
Butt Pain
WEB:http://www.medicinenet.com/buttock_pain/symptoms.htm
10048677
buttock pain AE
CTCAE:E12396
NCIt:C78228
a digestive system AE with an outcome of small white calcium lumps forming under the skin that may leak a chalky white fluid. These lumps are formed becuase of too much calcium in the diet.
SJ, YH
WEB: http://www.sclero.org/medical/symptoms/skin/calcinosis.html
10006938
These most commonly occur on the hands, or near joints such as elbows or knees, although they may appear anywhere. Calcinosis may range from one very tiny deposit, to large (and often painful) clusters.
calcinosis AE
an infection adverse event that caused by a species of the yeast Candida.
SJ, YH
WEB: http://medical-dictionary.thefreedictionary.com/candidiasis
10007152
This is a common cause of vaginal infections in women. Also, Candida may cause mouth infections in people with reduced immune function, or in patients taking certain antibiotics. Candida can be found in virtually all normal people but causes problems in only a fraction.
candidiasis AE
a hematology investigation result abnormal AE that occurs when the cardaic enzymes and proteins leak out of damaged heart muscle cells, and their levels in the bloodstream rise.
SJ, YH
URL: http://www.webmd.com/heart-disease/cardiac-enzyme-studies
10007548
cardiac enzymes increased AE may indicate that the heart muscle is injured, such as from a heart attack.
cardiac enzymes increased AE
Acute decompensated heart failure AE is a cardiovascular disorder AE that shows a worsening of the symptoms, typically shortness of breath (dyspnea), edema, and fatigue, in a patient with existing heart disease.
SJ, YH
Cardiac Failure Acute
WEB: http://en.wikipedia.org/wiki/Acute_decompensated_heart_failure
10007556
10064653
acute decompensated heart failure AE
Cardiac massage is a resuscitative procedure that employs the rhythmic compression of the chest and heart in an effort to restore and maintain the circulation after cardiac arrest or ventricular fibrillation
SJ, YH
Heart Massage
WEB: http://www.thefreedictionary.com/cardiac+massage
10059163
cardiac massage
Cardiac murmur AE is a cardiac disorder AE that is characterised by abnormal sounds during the heartbeat cycle — such as whooshing or swishing — made by turbulent blood in or near the heart.
SJ, YH
Heart Murmur
WEB: http://www.mayoclinic.org/diseases-conditions/heart-murmurs/basics/definition/con-20028706
10007586
cardiac murmur AE
a behavior and neurological AE that is seen most frequently in schizophrenia, characterized by muscular rigidity and mental stupor, sometimes alternating with great excitement and confusion.
YH, SJ
WEB: http://dictionary.reference.com/browse/catatonia
10007776
catatonia AE
a coronary artery disorder AE that results in narrowing of the inner surface of the carotid atery.
SJ, YH
WEB: http://en.wikipedia.org/wiki/Carotid_artery_stenosis
10007687
carotid artery stenosis AE
orbital cellulitis AE is a sudden infection of the tissues around the eye, affecting the eyelid, eyebrow, and cheek.
SJ, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001012.htm
10007918
orbital cellulitis AE
Chronic cholecystitis AE the inflammation of the gallbladder persisting for a prolonged period of time or having repeated attacks.
SJ, YH
WEB: http://www.healthline.com/health/chronic-cholecystitis#Overview1
10008617
chronic cholecystitis AE
a brain lesion AE is an area of injury or disease within the brain.
SJ, YH
WEB: http://www.webmd.com/brain/brain-lesions-causes-symptoms-treatments
10051290
brain lesion AE
Central venous pressure increased AE is a mesaurement of the pressure of the blood within the superior and inferior vena cava and large veins of the body. Increased pressure can be the result of cardiac failure and congestion of circulation.
SJ, YH
WEB: http://medical-dictionary.thefreedictionary.com/central+venous+pressure
10007980
central venous pressure increased AE
a brain disorder AE occurs when the brain is damaged by injury, disease, or health conditions.
SJ, YH
WEB: http://www.healthline.com/health/brain-disorders#Overview1
10054938
Brain disorders may affect the main areas of your brain that control how you move, think, and behave. Some tumors can constrict the blood vessels in your brain.
brain disorder AE
a cerebral infarction is a type of ischaemic stroke AE that is caused by a blockage in the blood vessels supplying blood to the brain.
SJ
WEB: http://en.wikipedia.org/wiki/Cerebral_infarction
10008118
cerebral infarction AE
a nervous system AE that occurs when the cerebrospinal fluid leaks through a defect in the dura or the skull and out through the nose or ear resulting from a tear in the dura.
SJ, YH, MW
cerebrospinal fluid leakage AE
WEB: http://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/brain_tumor/center/skull-base/types/csf-leak.html
10008164
cerebrospinal fluid leak AE
CTCAE: E12611
NCIt: C50487
a female reproductive system AE that refers to abnormal changes in the cells on the surface of the cervix. The changes are not cancer. But they can lead to cancer of the cervix if not treated.
SJ, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001491.htm
10008263
cervical dysplasia AE
a bone disorder AE that results in pain and neurological symptoms resulting from any type of condition that irritates a nerve in the cervical spine.
SJ, YH
WEB: http://www.spine-health.com/conditions/neck-pain/what-cervical-radiculopathy
10008303
cervical radiculopathy AE
Cervical spinal stenosis AE is a nervous system AE that occurs when the spinal canal in the neck narrows.
SJ, YH
WEB: http://www.webmd.com/back-pain/tc/cervical-spinal-stenosis-topic-overview
10008313
cervical spinal stenosis AE
a respiratory AE that results in the inability to breath because something gets stuck in the throat or because the air is not good for breathing
SJ, YH
WEB: http://www.merriam-webster.com/dictionary/choke
10008589
choking AE
a musculoskeletal and connective tissue AE that results in tlhe disappearance of articular cartilage as the result of disintegration or dissolution of the cartilage matrix and cells.
SJ, YH
WEB: http://www.medilexicon.com/medicaldictionary.php?t=17184
10058112
chondrolysis AE
A joint disorder AE in which the cartilage on the undersurface of the patella deteriorates and softens.
SJ, YH
WEB: http://www.healthline.com/health/chondromalacia-patella#Overview1
10008729
chondromalacia AE
an adverse event that occurs after a therapeutic intervention
YH, JX
therapy adverse event
a therapeutic intervention that remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, and physical intervention
YH, JX
physical therapy
WEB: http://en.wikipedia.org/wiki/Physical_therapy
physiotherapy
a seizure AE that resutls in jerking and muscle rigidity, unusual sensations affecting vision, hearing, smell, taste or touch, and memory or emothional disturbances.
YH, SJ
WEB: http://www.webmd.com/epilepsy/guide/types-of-seizures-their-symptoms?page=2
10040703
simple partial seizure AE
chemosis AE is a conjunctival disorder AE that results in swelling of the conjunctiva die to exudation of abnormaly permeable capillaries.
SJ, YH
conjunctival edema
WEB: http://en.wikipedia.org/wiki/Chemosis
10053163
chemosis AE
a therapeutic intervention that is used in critically ill patients who have experienced multisystem organ failure and in whom acute renal failure has developed.
YH, SJ
WEB: http://www.medilexicon.com/medicaldictionary.php?t=40071
10066348
continuous venovenous hemodiafiltration
a behavior and neurological AE that results in the expression of psychlogical stress in physical ways or a mental or emotional crises that begins to have a physical affect.
YH, SJ
functional neurological symptom disorder
WEB: http://www.mayoclinic.org/diseases-conditions/conversion-disorder/basics/definition/con-20029533
10010893
conversion disorder AE
a cardiac disorder AE which causes a thickening and loss of elasticity of the coronary arteries, leading to progressive insufficiency of the arteries.
SJ, YH
arteriosclerotic coronary artery disease
coronary artery atherosclerosis
WEB: http://ghr.nlm.nih.gov/glossary=coronaryarteriosclerosis
10011076
coronary arteriosclerosis AE
a cardiac disorder AE which causes a partial or complete blockage of the coronary artery which can lead to heart attack.
SJ, YH
WEB: http://en.wikipedia.org/wiki/Coronary_occlusion
10011086
coronary occlusion AE
a cardiac disorder AE which results in inflammation and the buildup of plaque which narrow the coronary arteries.
SJ, YH
WEB: http://www.mayoclinic.org/diseases-conditions/coronary-artery-disease/basics/definition/con-20032038
10011089
coronary artery disease AE
An joint disorder AE that results in the noise produced by the rubbing together of bone or irregular cartilage surfaces.
YH, SJ
WEB: http://medical-dictionary.thefreedictionary.com/crepitation
10011376
crepitation AE
cryptorchidism AE is a male reproductive system AE which results in the absence of one or both testes from the scrotum.
YH, SJ
undescended testis
WEB: http://en.wikipedia.org/wiki/Cryptorchidism
10011498
cryptorchidism AE
CSF glucose is proportional to blood glucose levels which correspond to 60-70% of the concentration in blood.
SJ, YH
hypoglycorrhachia
10011537
decreased CSF glucose AE can be caused by CNS infections, inflammatory conditions, subarachnoid hemorrhage, hypoglycemia, impaired glucose transport, increased CNS glycolytic activity and metastatic carcinoma.
decreased CSF glucose AE
wound culture positive AE is a a test to find and identify germs that may be growing on the skin or in a wound. If something that can cause infection grows, the culture is positive. The type of organisms may be identified with a microscope, chemical tests, or both.
SJ, YH
WEB: http://www.webmd.com/a-to-z-guides/skin-and-wound-cultures
10011643
wound culture positive AE
skin cyst AE is a skin AE that occurs when a cluster of cells that have grouped together to form a sac which may contain air, fluids, or semi-solid material.
YH, SJ
cyst
WEB: http://en.wikipedia.org/wiki/Cyst
10011732
skin cyst AE
conductive hearing loss AE is a hearing loss AE that results from probelms with the ear canal, ear drum, or middle ear and its little bones.
SJ, YH
sensorineural hearing loss (SNHL)
WEB: http://www.hearingloss.org/content/types-causes-and-treatment
10010282
conductive hearing loss AE
transient hearing loss AE is a hearing loss AE that results from poor ventilation of the middle ear in children.
SJ, YH
deafness transitory
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139416/
10011900
transient hearing loss AE
a psychiatric disorder AE that results in a persistent false psychotic belief regarding the self or objects outside the self that is maintained despite indisputable evidence to the contrary.
SJ, YH
WEB: http://www.merriam-webster.com/dictionary/delusion
10012239
delusion AE
a behavioral and neurological AE that results in long-standing need for the person to be taken care of and a fear of being abandoned or separated from important individuals.
SJ, YH
WEB: http://psychcentral.com/disorders/dependent-personality-disorder-symptoms/
10012355
Individuals with Dependent Personality Disorder are often characterized by pessimism and self-doubt, and tend to belittle their abilities and assets. This leads the person to engage in dependent and submissive behaviors that are designed to elicit care-giving behaviors in others.
dependent personality disorder AE
Nervous system AE that results in failure to meet certain developmental milestones, such as sitting, walking, and talking, at the average age. Developmental delay may indicate a problem in development of the central nervous system.
SJ, YH
WEB: http://medical-dictionary.thefreedictionary.com/developmental+delay
10012559
developmental delay AE
diabetic ketoacidosis AE is a cardiovascular AE that develops when your body is unable to produce enough insulin and begins to break down fat as an alternate fuel, this process produces a buildup of toxic acids in the bloodstream called ketones.
SJ, YH
WEB: http://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/basics/definition/con-20026470
10012671
diabetic ketoacidosis AE
Dialysis is the process of removing waste products and excess fluid from the body when the kidneys are not able to adequately filter the blood.
YH, SJ
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=2980
10061105
dialysis
congenital diaphragmatic hernia AE is a congential disorder in which an absent or partially formed diaphragm results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs. This crowding can lead to underdevelopment of the lungs, potentially resulting in life-threatening breathing difficulties that are apparent from birth.
SJ, YH
WEB: http://medical-dictionary.thefreedictionary.com/aspiration
10061106
congenital diaphragmatic hernia AE
a paralysis AE that has an outcome of paralysis affecting symmetrical parts of the body.
SJ, YH
WEB: http://en.wikipedia.org/wiki/Diplegia
10013033
diplegia AE
cystitis interstitial AE is a cystitis AE that has an outcome of cystitis interstitial, which is a condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/interstitialcystitis.html
10011796
cystitis interstitial AE
A disseminated tuberculosis AE is a tuberculosis AE that has an outcome of disseminated tuberculosis, which is a contagious bacterial infection in which TB bacteria has spread from the lungs to other parts of the body through the blood or lymph system.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000624.htm
10013453
disseminated tuberculosis AE
Exotosis AE is a bone pain AE that has resulted in a non-neoplastic overgrowth of bone.
KM, YH
WEB: http://en.wikipedia.org/wiki/Exostosis
10015688
exotosis AE
An exudative retinopathy AE is an eye AE that shows an outcome of exudative retinopathy marked by masses of white or yellowish exudate in the posterior part of the fundus oculi, with deposits of cholesterol and blood debris from retinal hemorrhage, that leads to destruction of the macula and blindness.
KM, YH
Coats' disease, Coats' retinitis
WEB: http://medical-dictionary.thefreedictionary.com/exudative+retinopathy
10015901
exudative retinopathy AE
A tendon disorder AE that has an outcome of tendinous which is damage to a tendon at a cellular level. It is thought to be caused by microtears in the connective tissue in and around the tendon, leading to an increase in tendon repair cells.
KM, YH
WEB: http://en.wikipedia.org/wiki/Tendinosis
10016662
tendinous AE
A monocyte percentage abnormal AE that results in abnormally high levels of monocytes in the blood.
KM, YH
WEB: http://en.wikipedia.org/wiki/Monocytosis
10027906
monocytosis AE
NCIT: C35147
A male reproductive system AE that has an outcome of genital candidiasis, which is a fungal infection due to any types of Candida (types of yeasts). This is a fungal infection of the genital region.
KM, YH
WEB: http://en.wikipedia.org/wiki/Candidiasis
WEB: http://www.cdc.gov/fungal/diseases/candidiasis/genital/
10018143
genital candidiasis AE
KM, YH
WEB: http://www.webmd.com/pain-management/tc/groin-problems-and-injuries-topic-overview
10018735
A groin pain AE is a pain AE that shows a pain in the groin area.
groin pain AE
A blood disorder AE that has an outcome of the breakdown of red blood cells.
KM, YH
hemolysis
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/002372.htm
10018910
haemolysis AE
A hepatosplenomegaly AE is a liver inflammation AE that has an outcome of an abnormal enlargement of the liver and spleen.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/imagepages/17215.htm
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=3716
10019847
hepatosplenomegaly AE
A gastric disorder AE that occurs when part of your stomach pushes upward through your diaphragm.
KM, YH
WEB: http://www.mayoclinic.org/diseases-conditions/hiatal-hernia/basics/definition/con-20030640
10020028
hiatus hernia AE
A viral infection AE that is caused by the human immunodeficiency virus.
KM, YH
10020161
HIV infection AE
NCIT: C3108
A hypertonic bladder AE is a digestive system AE that where the bladder-storage function that causes a sudden urge to urinate.
SJ, YH
irritable bladder
overactive bladder
WEB: http://healbladder.info/healbladder/hypertonic-bladder
WEB: http://www.mayoclinic.org/diseases-conditions/overactive-bladder/basics/definition/con-20027632
10020853
hypertonic bladder AE
A hypovitaminosis AE is a gustatory system AE which shows an insufficiency of one or more essential vitamins.
KM, YH
WEB: http://en.wikipedia.org/wiki/Hypovitaminosis
10021135
hypovitaminosis AE
A gastrointestinal disorder AE that shows the inflammation of the ileum.
KM, YH
WEB: http://en.wikipedia.org/wiki/Ileitis
10021312
ileitis AE
NCIT: C84782
A joint pain AE that occurs when there is an abnormal separation in the joint, where two or more bones meet.
KM, YH
dislocated joint, luxation
WEB: http://en.wikipedia.org/wiki/Joint_dislocation
10023204
joint dislocation AE
A syndrome AE that shows Kawasaki's disease, a vasculitis characterized by inflammation of the arteries, particularly the coronary arteries. The vasculitis may lead to aneurysm formation and possibly, heart attacks. It affects young children who usually present with persistent high fever, redness of the mucous membranes of the mouth, redness of the palms and soles, skin rashes, lymphadenitis, and joint pain and swelling.
KM, YH
Mucocutaneous Lymph Node Syndrome
WEB: http://en.wikipedia.org/wiki/Kawasaki_disease
10023320
kawasaki disease AE
NCIT: C34825
An abscess AE where a bacterial, parasitic, or fungal abscess that develops in the liver. It is usually the result of an abdominal infection, trauma, or surgery in the right upper quadrant. Signs and symptoms include abdominal pain, nausea, vomiting, and fever.
KM, YH
WEB: http://en.wikipedia.org/wiki/Liver_abscess
10024652
liver abscess AE
NCIT: C99089
A blood disorder AE that the body's blood supply will stop moving after the heart has stopped pumping it around the inside of the deceased.
KM, YH
WEB: http://www.exploreforensics.co.uk/rigor-mortis-and-lividity.html
10024728
lividity AE
A lymphangitis AE is an inflammation AE that has an infection of the lymph vessels (channels).
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/007296.htm
10025226
lymphangitis AE
An infection adverse event that results in malaria, a protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia.
KM, YH
WEB: http://en.wikipedia.org/wiki/Malaria
10025487
malaria AE
NCIT: C34797
A metabolic disoder AE where there is increased acidity in the blood secondary to acid base imbalance. Causes include diabetes, kidney failure and shock.
KM, YH
Acidosis
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000335.htm
10027417
metabolic acidosis AE
NCIT: C28228
An abnormal stool AE that has an outcome of a significant amount of mucus in the stool. The mucus is accompanied by diarrhea, pain or blood may signify an intestinal condition such as infection or inflammation. Increased amounts of mucus in the stool can also occur with cancers of the colon or rectum or with bowel obstruction.
KM, YH
WEB: http://www.healthgrades.com/symptoms/mucus-in-stool
10028140
mucous stool AE
A muscle spasm AE that has an outcome of tight or stiff muscles and an inability to control those muscles.
KM, YH, MW, MW
spasticity AE
WEB: http://www.webmd.com/pain-management/pain-management-spasticity
10028335
10041416
muscle spasticity AE
CTCAE: E12820
NCIt: C79750
A respiratory distress AE that has an outcome of a newborn dyspnea (i.e., impaired breathing) with cyanosis, most frequently occurring in premature infants, children of diabetic mothers and infants delivered by cesarean section, and sometimes with no predisposing cause.
KM, YH
Newborn Respiratory Distress Syndrome
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001563.htm
10001052
neonatal respiratory distress AE
NCIT: C27560
A neutrophil count increased AE that has an outcome of an abnormally high level of neutrophils in the blood.
KM, YH
WEB: http://en.wikipedia.org/wiki/Neutrophilia
10029379
neutrophilia AE
NCIT: C35164
A male reproductive system AE that results in an inflammation of one or both testes due to viral or bacterial infections. Signs and symptoms include enlargement or tenderness of the affected testis, inguinal lymphadenopathy, blood in the semen, and pain during urination, intercourse, or ejaculation.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001280.htm
10031064
orchitis AE
NCIT: C97145
an inflammation AE that occurs in a bone.
KM, YH
Osteitis fibrosa
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001252.htm
10031149
osteitis AE
A bone disorder AE that has an dissolution of bone, especially the removal or loss of the calcium of bone.
KM, YH
WEB: http://en.wikipedia.org/wiki/Osteolysis
10031248
osteolysis AE
NCIT: C50681
An arrhythmia AE that has an outcome of palpitations, an abnormality of heartbeat characterized by simultaneous awareness of one’s pulse and discomfort.
KM, YH
WEB: http://en.wikipedia.org/wiki/Palpitations
10033557
palpitations AE
CTCAE: E10163
NCIt: C37999
A skin AE that shows a solid, raised spot on the skin that is up to 0.5 centimeter wide, which is a type of skin lesion.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003233.htm
10033733
papule AE
A parotid gladn enlargement AE that has an outcome of parotitis, the inflammation of one or more of the parotid glands.
KM, YH
WEB: http://emedicine.medscape.com/article/882461-overview
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001041.htm
10034038
parotitis AE
A male reproductive system AE that has an disorder in a penis, including priapism, Peyronie's disease, balanitis, phimosis, paraphimosis, and penile cancer.
KM, YH
WEB: http://www.medicinenet.com/penis_disorders/article.htm
10034336
penis disorder AE
An abdominal AE that shows an inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs.
KM, YH
WEB: http://en.wikipedia.org/wiki/Peritonitis
10034674
peritonitis AE
NCIT: C26849
A medical intervention that collects plasma from the peripheral blood while returning the rest to the donor.
KM, YH
plasma exchange
therapeutic plasma exchange
WEB: http://en.wikipedia.org/wiki/Plasmapheresis
10035486
plasmapheresis AE
NCIT: C15304
An arthritis AE that has an outcome of polyarthritis, which includes any type of arthritis that involves 5 or more joints simultaneously.
KM, YH
WEB: http://en.wikipedia.org/wiki/Polyarthritis
10036030
polyarthritis AE
A male reproductive system AE that affects prostatic gland in the male reproductive system.
KM, YH
WEB: http://www.britannica.com/EBchecked/topic/479519/prostatic-disorder
10036956
prostatic disorder AE
A tumor AE that shows a benign disorder of lymphoid cells or histiocytes that produces clinical features of a malignant lymphoma.
KM, YH
WEB: http://medical-dictionary.thefreedictionary.com/pseudolymphoma
10037108
pseudo lymphoma AE
A skin AE that shows a pyogenic skin disease. These include superficial bacterial infections such as impetigo, impetigo contagiosa, ecthyma, folliculitis, Bockhart's impetigo, furuncle, carbuncle, tropical ulcer, etc.
KM, YH
WEB: http://en.wikipedia.org/wiki/Pyoderma
10037632
pyoderma AE
A urine abnormality AE that shows the presence of white blood cells or pus in the urine, usually a sign of urinary tract infection.
KM, YH
WEB: http://en.wikipedia.org/wiki/Pyuria
WEB: http://medical-dictionary.thefreedictionary.com/pyuria
10037686
pyuria AE
a blood sodium abnormal AE that is characterized by an abnormally high level of sodium in the blood
YH, MW
hypernaetremia
WEB: http://emedicine.medscape.com/article/241094-overview
10020679
10020680
hypernatremia AE
CTCAE: E12293
HPO: HP_0003228
NCIt: C37970
SIDER: C0595878
A rash AE that shows a rash like measles. The rash consists of macular lesions that are red and usually 2–10 mm in diameter but may be confluent in places.
KM, YH
measles-like maculopapular rash AE
WEB: http://en.wikipedia.org/wiki/Morbilliform
WEB: http://www.wisegeek.com/what-is-a-morbilliform-rash.htm
10037870
morbilliform rash AE
A rash AE that shows a raised, blistery rash.
KM, YH
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=11955
10037898
vesicular rash AE
A red blood cell count increased AE that has an increased count of reticulocytes in the blood. Reticulocytes are slightly immature red blood cells.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003637.htm
10038792
reticulocyte count increased AE
a behavior and neurological AE that results in impaired or inhibited ego functioning in which the ability to process reality-based information is diminished and disordered.
SJ, YH
WEB: http://medical-dictionary.thefreedictionary.com/acute+psychosis
10001022
acute psychosis AE
An eye AE that shows an abnormal blood vessel development in the retina of the eye and it occurs in infants that are born too early.
KM, YH
Terry syndrome
retrolental fibroplasia
retrolental fibroplasia (RLF)
WEB: http://en.wikipedia.org/wiki/Retinopathy_of_prematurity
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/001618.htm
10038933
retinopathy of prematurity AE
A skin AE that results in a scar, a mark left on the skin.
KM, YH
WEB: http://en.wikipedia.org/wiki/Scar
10039580
scar AE
NCIT: C34483
A skin AE that has an outcome of a localized or systemic chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues.
KM, YH
WEB: http://en.wikipedia.org/wiki/Scleroderma
10039710
Localized scleroderma affects only the skin. Systemic scleroderma affects internal organs, including the heart, lungs, gastrointestinal tract, and kidneys.
scleroderma AE
NCIT: C26746
A male reproductive system AE that has an outcome of an abnormal enlargement of the scrotum, the sac surrounding the testicles.
KM, YH
scrotal edema
scrotal swelling
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003161.htm
10039755
scrotal oedema AE
A skin AE that results in the degeneration and thinning of the epidermis and dermis.
KM, YH, MW
atrophy of the skin
WEB: http://www.wisegeek.com/what-is-skin-atrophy.htm
10040799
skin atrophy AE
CTCAE:E13714
NCIT: C35163
NCIt:C35163
A skin discoloration AE that shows the lightening of the skin, or loss of pigment.
KM, YH
Depigmentation
WEB: http://en.wikipedia.org/wiki/Depigmentation
皮肤脱色
10040825
skin depigmentation AE
A skin discoloration AE that shows abnormal lightening of skin due to decreased melanin production or deposition.
KM, YH, MW
Hypopigmentation, Pigment Dilution
WEB: http://en.wikipedia.org/wiki/Hypopigmentation
10040868
Vitiligo, albinism, and leukoderma are among the disorders that are associated with skin hypopigmentation.
skin hypopigmentation AE
CTCAE:E13721
NCIt:C78610
http://en.wikipedia.org/wiki/Hypopigmentation
An immune system disorder AE that has an disorder in spleen, the largest organ in the lymphatic system.
KM, YH
splenic diseases
WEB: http://en.wikipedia.org/wiki/Splenic_disease
WEB: http://www.livescience.com/44725-spleen.html
10041633
spleen disorder AE
CTCAE: E10056
NCIt: C35823
a muscle AE that shows the absence or loss of control of voluntary muscle movements.
SJ, YH
URL: http://medical-dictionary.thefreedictionary.com/akinesia
10001541
akinesia AE
a seizure AE that shows a brief episode of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.
JX, YH
epilepsy
WEB: http://en.wikipedia.org/wiki/Epileptic_seizure
癫痫
epileptic seizure AE
a cranial neuropathy AE which shows an damage or abnormality to the nerves in the eyes.
RR, YH
WEB: http://www.allaboutvision.com/conditions/optic-neuritis.htm
10061323
optic neuropathy AE
an optic neuropathy AE characterized by optic disc swelling, peripapillary and macular hard exudates, and vitreous cells.
RR, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/6466175
10060701
neuroretinitis AE
an optic neuropathy AE characterized by vision loss, optic disc swelling, flame hemorrhages, and cotton-wool exudates. It occurs when blood flow is interrupted to the front (anterior) part of the optic nerve (also called optic nerve head).
RR, YH
AION
WEB: http://emedicine.medscape.com/article/1216891-overview
WEB: http://www.geteyesmart.org/eyesmart/diseases/ischemic-optic-neuropathy/
10068250
anterior ischemic optic neuropathy AE
a type of anterior ischemic optic neuropathy AE that presents primarily with vision loss, especially upon wakening, and sectorial disc edema.
RR, YH
WEB: http://emedicine.medscape.com/article/1216891-clinical#a0217
10068249
non-arteritic anterior ischemic optic neuropathy AE
a peripheral neuropathy AE that shows a combination of axonal and demyelinating neuropathy.
RR, YH
WEB: http://www.aafp.org/afp/2010/0401/p887.html
mixed neuropathy AE
a peripheral sensory neuropathy AE that shows neuropathy in many sensory nerves at one time
RR, YH
WEB: http://www.merckmanuals.com/home/brain_spinal_cord_and_nerve_disorders/peripheral_nerve_disorders/polyneuropathy.html
sensory peripheral polyneuropathy AE
a peripheral neuropathy AE that results from the loss of the myelin sheath on peripheral nerves roughly evenly distributed on both sides of the body
RR, YH
peripheral demyelinating polyneuropathy AE
a neuropathy AE that shows nerve damage and occurs in a patient with diabetes
RR, YH
WEB: http://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/basics/definition/con-20033336
10012680
diabetic neuropathy AE
a nervous system AE that is an umbrella term referring to conditions relating to the nervous system, including loss of sensation and paralysis
RR, YH
WEB: http://en.wikipedia.org/wiki/Functional_neurological_deficit
neurological deficit AE
An abscess AE that is caused by an Staphylococcus aureus infection.
KM, YH
abscess
http://medical-dictionary.thefreedictionary.com/staphylococcal+abscess
10041917
staphylococcal abscess AE
An eye AE that results in an intermittent or constant misalignment of an eye so that its line of vision is not pointed at the same object. Strabismus is caused by an imbalance in the extraocular muscles which control the positioning of the eyes.
KM, YH
cross-eyed
heterotropia
wall-eyed
WEB: http://en.wikipedia.org/wiki/Strabismus
10042159
strabismus AE
A vein discoloration AE that has an outcome of local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes.
KM, YH, MW
http://en.wikipedia.org/wiki/Telangiectasia
10043189
telangiectasia AE
CTCAE:E13740
NCIT: C28194
NCIt:C28194
A muscle spasm AE that results in the lack of ability to open the mouth fully due to decreased range of motion of the muscles of mastication.
KM, YH, MW
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=40739
10044684
Trismus is a symptom of tetanus.
trismus AE
CTCAE:E12541
NCIt: C78651
A bacterial infection AE with an outcome of thypoid fever, a bacterial infectious disorder caused by the Salmonella typhi bacteria.
KM, YH
tyhpoid
WEB: http://www.webmd.com/a-to-z-guides/typhoid-fever
10045275
Typhoid fever is often contracted by consumption of food or drink contaminated with Salmonella typhi.
typhoid fever AE
NCIT: C35089
a urinary system AE that results in the inflammation (swelling and irritation) of the urethra.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000439.htm
10046480
urethritis AE
a skin discoloration AE which shows a chronic skin disease characterized by portions of the skin losing their pigment.
KM, YH
WEB: http://en.wikipedia.org/wiki/Vitiligo
白癫风;白驳风;白斑
10047642
vitiligo AE
NCIT: C26915
an injury AE that displays a type of injury to flesh or skin caused by heat, electricity, chemicals, friction, or radiation.
YH
WEB: http://en.wikipedia.org/wiki/Burn
10006634
burn AE
CTCAE: E11669
NCIt: C34441
a hematopoietic system AE which has a decreased erythrocyte sedimentation rate (ESR). EST is the rate at which red blood cells sediment in a period of one hour.
KM, YH
ESR
erythrocyte sedimentation rate
red blood cell sedimentation rate decreased AE
Westergren ESR decreased AE
http://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate
10049188
sedimentation rate decreased AE
a skin AE that has decreased skin turgor which is the skin's ability to change shape and return to normal (elasticity).
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003281.htm
10049428
skin turgor decreased AE
A tumor AE that shows a tumor occuring in the gastrointestinal tract.
KM, YH
WEB: http://ghr.nlm.nih.gov/condition/gastrointestinal-stromal-tumor
10051066
gastrointestinal stromal tumour AE
A bacterial infection AE that has the presence of pus in a bacterial infection.
KM, YH
WEB: http://dermatology.about.com/library/bldeffluctuance.htm
10051723
fluctuance AE
A bacterial infection AE which is caused by Acinetobacter.
KM, YH
WEB: http://www.cdc.gov/HAI/organisms/acinetobacter.html
10051894
Outbreaks of Acinetobacter infections typically occur in intensive care units and healthcare settings housing very ill patients. Acinetobacter infections rarely occur outside of healthcare settings.
acinetobacter infection AE
an injury AE that breaks the skin or other body tissues.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/woundsandinjuries.html
10052428
wound AE
a tuberculosis AE which is an invasion of the peritoneum by Mycobacterium tuberculosis.
KM, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmed/21215540
10053583
peritoneal tuberculosis AE
a tumor AE that shows a benigh tumor of vascular origin usually seen in early childhood.
YH
WEB: http://radiopaedia.org/articles/haemangioma
haemangioma AE
a vascular disorder AE that has an outcome of the blockage of a blood vessel, usually with a clot.
KM, YH
WEB: http://en.wikipedia.org/wiki/Vascular_occlusion
10053648
vascular occlusion AE
a tuberculosis AE that shows an tuberculosis of the joints.
KM, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577591/
10056367
joint tuberculosis AE
an arrhythmia AE that shows abnormal heart rhythms that originate in the bottom chambers of the heart called the ventricles.
LW, YH
WEB: http://my.clevelandclinic.org/services/heart/departments-centers/ventricular-arrhythmia-center
室性心律失常
10047281
ventricular arrhythmia AE
CTCAE: E10230
NCIt: C26924
A bacterial infection AE that is caused by Salmonella.
KM, YH
WEB: http://en.wikipedia.org/wiki/Salmonella
10058878
Salmonella AE
a blood potassium abnormal AE that has a lab test outcome of abnormally lower than normal amount of potassium in the blood
YH, MW
hypokalemia AE
hypopotassaemia AE
hypopotassemia AE
potassium depletion AE
WEB: http://en.wikipedia.org/wiki/Hypokalemia
WEB: http://medical-dictionary.thefreedictionary.com/hyperkalemia
WEB: http://www.emedicinehealth.com/low_potassium/article_em.htm
血钾过少
10021015
10021018
hypokalaemia AE
CTCAE: E12327
NCIt: C37974
a necrosis AE, tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (adipokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.
KM, YH
WEB: http://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha
10059981
alpha tumour necrosis factor AE
a tumor AE that that is a benign or malignant neoplasm involving the oral cavity and/or the lips.
KM, YH
WEB: http://www.nlm.nih.gov/medlineplus/oralcancer.html
10061325
oral neoplasm AE
NCIT: C8989
a cardiac disorder AE that can present clinically as acute pericarditis, pericardial effusion, cardiac tamponade, and constrictive pericarditis.
KM, YH
WEB: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878263/
10061338
pericardial disease AE
a tumor AE that shows a benign or malignant neoplasm that affects the peritoneal cavity.
KM, YH
WEB: http://www.webmd.com/cancer/peritoneal-cancer-prognosis-symptoms-treatments
10061344
Representative examples of benign neoplasms include adenomatoid tumor and disseminated peritoneal leiomyomatosis. Representative examples of malignant neoplasms include primary peritoneal carcinoma, metastatic carcinoma to the peritoneum, and malignant mesothelioma.
peritoneal neoplasm AE
NCIT: C3322
an inflammation AE that shows the formation or presence of pus.
KM, YH
MedDRA: 10061926
WEB: http://medical-dictionary.thefreedictionary.com/purulence
purulence AE
a bacterial infection AE with bacteria of the genus Mycobacterium.
KM, YH
Mycobacterium Infection
WEB: http://www.nlm.nih.gov/medlineplus/mycobacterialinfections.html
10062207
mycobacterial infection AE
NCIT: C26831
a tumor AE that shows the most common benign spinal neoplasm, often located in the thoracic and lumbar spine, with a peak incidence of occurrence in the fourth to sixth decades.
KM, YH
WEB: http://radiopaedia.org/articles/vertebral-haemangioma
10065275
spinal haemangioma AE
a syndrome AE that reuslts in an autosomal recessive combined immunodeficiency syndrome caused by mutations in the RAG-1 and RAG-2 genes. It is characterized by the presence of alopecia, erythroderma, desquamation, lymphadenopathy, and chronic diarrhea.
YH: This is also a genetic AE. We will later find a way to link to there.
KM, YH
WEB: http://en.wikipedia.org/wiki/Omenn_syndrome
10069097
Omenn syndrome AE
NCIT: C61240
a immune system AE that results in a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.
KM, YH
WEB: http://en.wikipedia.org/wiki/Immunodeficiency
immunodeficiency AE
a hepatitis AE that resutls in a hepatitis C viral infection.
KM, YH
HCV
WEB: http://en.wikipedia.org/wiki/Hepatitis_C_virus
hepatitis C AE
NCIT: C14312
a blood phosphorus abnormal AE that shows an abnormal blood phosphate level
EB
10054823
blood phosphate abnormal AE
a hematology investigation result abnormal AE that results in an abnormal level of albumin in the blood
EB
10005800
blood albumin abnormal AE
an electrolyte blood lab test abnormal AE that results in an abnormal level of sodium in the blood
YH, MW
blood carbon dioxide abnormal AE'
a blood carbon dioxide abnormal AE in which the levels of carbon dioxide in the blood is abnormally high
DJ, SS, YH, MW
CO2 retention AE
hypercapnea AE
hypercarbia AE
WEB: https://en.wikipedia.org/wiki/Hypercapnia
10020591
hypercapnia AE
UMLS CUI: C0020440
A physical quality that has an decreased level of glucose in the blood
EB, YH, MW
10005555
blood glucose decreased
UMLS CUI: C0595883
A physical quality that has an increased level of glucose in the blood
EB, YH, MW
10005557
blood glucose increased
UMLS CUI: C0595877
a rash AE that shows follicular eruptions characterized by papules and pustules resembling acne.
YH, MW
acneiform eruption AE
rash acneiform AE
WEB: http://en.wikipedia.org/wiki/Acne_vulgaris
WEB: http://en.wikipedia.org/wiki/Acneiform_eruption
10037847
The term "acneiform", literally, refers to an appearance similar to acne. Acne vulgaris (or simply acne) is a long-term skin condition characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring.
acneiform rash AE
CTCAE: E13694
NCIt: C35277
A rash AE that is characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back.
YH
WEB: http://www.medaphile.com/medical-dictionary/papulopustular-rash
10069138
Unlike acne, papulopustular rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions.
papulopustular rash AE
CTCAE: E11491
NCIt: C80119
an neuropathy AE that occurs when any of the twelve cranial nerves (nerves that exit from the brain directly) are damaged.
MW, YH
WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy
10061096
cranial neuropathy AE
a cranial neuropathy AE which shows an damage or abnormality to the nerve that carries signals from the inner ear to the brain and is responsible for hearing.
MW, YH
WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy
auditory neuropathy AE
a cognitive disorder AE that shows conspicuous changes in cognitive functions.
MW, YH
10009845
cognitive disturbance AE
CTCAE: E12617
NCIt: C27101
an neuropathy AE that is restricted to one nerve or group of nerves, or one area of the body
MW, YH
WEB: http://www.emedicinehealth.com/neuropathy/article_em.htm#types_of_neuropathy
focal neuropathy AE
a vascular disorder AE that form in a blood vessel a clot (thrombus) that breaks loose and is carried by the blood stream to plug another vessel.
MW, YH
thromboembolic event AE
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=25032
10043565
thromboembolism AE
CTCAE: E13825
an injury AE that occurs in the cardiovascular system
YH
10007654
cardiovascular injury AE
UMLS CUI: C0560570
a cardiovascular injury AE that occurs in a heart.
YH
10061200
heart injury AE
UMLS CUI: C0018805
a heart injury AE that shows a laceration or tearing of the myoardium, which is the muscular tissue of the heart.
YH
WEB: https://en.wikipedia.org/wiki/Myocardial_rupture
10028604
myocardial rupture AE
UMLS CUI: C0018813
a cardiomyopathy AE that is characterized by a weekened heart caused by the effects of high blood pressure.
YH
WEB: http://www.freemd.com/hypertensive-cardiomyopathy/overview.htm
10058222
hypertensive cardiomyopathy AE
UMLS CUI: C1144799
A hypertrophic cardiomyopathy AE where the distortion of normal heart anatomy causes an obstruction of the outflow of blood from the left ventricle of the heart
YH
ASH
HOCM
IHSS
asymmetric septal hypertrophy
idiopathic hypertrophic subaortic stenosis
WEB: https://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy#Obstructive_and_non-obstructive
10020204
hypertrophic obstructive cardiomyopathy AE
UMLS CUI: C0007194
A hypertrophic cardiomyopathy AE where the distortion of normal heart anatomy does not cause an obstruction of the outflow of blood from the left ventricle of the heart
YH
Yamaguchi Hypertrophy
Yamaguchi Syndrome
apical hypertrophic cardiomyopathy
idiopathic hypertrophic subaortic stenosis
non-obstructive cardiomyopathy
WEB: http://medical-dictionary.thefreedictionary.com/cardiomyopathy
WEB: https://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy#Obstructive_and_non-obstructive
hypertrophic non-obstructive cardiomyopathy AE
a cardiovascular investigation result abnormal AE that results in an abnormal result on a test used to evaluate heart function
YH
WEB: http://www.drsinatra.com/heart-function-tests-to-assess-heart-disease-risk/
WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures
10058479
cardiac function test abnormal AE
UMLS CUI: C0438177
a cardiac disorder AE that results in multiple cardiac defects.
YH
WEB: https://en.wikipedia.org/wiki/Cardiology_diagnostic_tests_and_procedures
10058479
multiple cardiac defects AE
UMLS CUI: C0438177
an injury and procedural complication AE that results in a blockage of a device.
YH
10064685
device occlusion AE
UMLS CUI: C1608397
a procedural complication AE that occurs after the usage of a device.
YH
device AE
a skin ulceration AE that has a combined area of ulcers <1 cm and nonblanchable erythema of intact skin with associated warmth or edema
MW, YH
WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx
Grade 1 skin ulceration AE
CTCAE: E13731
a skin ulceration AE that has a combined area of ulcers 1 - 2 cm and partial thickness skin loss involving skin or subcutaneous fat
MW, YH
WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx
Grade 2 skin ulceration AE
CTCAE: E13732
a skin ulceration AE that has a combined area of ulcers >2 cm and full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia
MW, YH
WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx
Grade 3 skin ulceration AE
CTCAE: E13733
a skin ulceration AE that has any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss
MW, YH
WEB: http://www.nhs.uk/Conditions/Pressure-ulcers/Pages/Symptoms.aspx
Grade 4 skin ulceration AE
CTCAE: E13734
A dysesthesia AE that shows an uncomfortable persistent sensation in the area of the laryngopharynx.
MW, YH
10062667
Laryngopharyngeal dysesthesia AE
CTCAE: E13433
NCIt: C78414
a hospitalization AE that leads to an intial hospitalization.
YH, JX
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
initial hospitalization AE
a hospitalization AE that leads to a prolonged hospitalization.
YH, JX
WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
prolonged hospitalization AE
an adverse event that occurs locally in a certain location. This is different from the systematci adverse event that occurs throughout the systemtic circulation.
YH, JX
URL: https://en.wikipedia.org/wiki/Adverse_drug_reaction
local AE
an adverse event that shows a result of injury or procedural complication.
JX, YH
injury and procedural complication AE
injury or procedural complication AE
a nervous system AE that occurs in the central nervous system
JX, YH
central nervous system AE
a nervous system AE that occurs in the area of meninges
JX, YH
WEB: https://en.wikipedia.org/wiki/Meninges
meninges AE
an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain
According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543).
meninges inflammation AE
MP: MP_0001847
a mental disorder that has false personal beliefs held contrary to reality, despite contradictory evidence and common sense.
MW, YH
10012260
delusions AE
CTCAE: E12904
NCIt: C26741
an inflammation AE that has an inflammation involving the larynx.
MW, YH
10065735
laryngeal inflammation AE
CTCAE: E13411
NCIt: C26811
a male reproductive system AE that has involvement of the testis.
MW, YH
10043306
testicular disorder AE
CTCAE: E13215
NCIt: C26890
an urinary system AE that has urination at short intervals.
MW, YH
10046539
urinary frequency AE
CTCAE: E13039
NCIt: C26906
a reproduction system inflammation AE that has inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge.
MW, YH
10046916
vaginal inflammation AE
CTCAE: E13270
NCIt: C26911
a cranial neuropathy AE that has involvement of the trigeminal nerve (fifth cranial nerve).
MW, YH
10060890
trigeminal nerve disorder AE
CTCAE: E12841
NCIt: C26952
cranial neuropathy AE that has involvement of the accessory nerve (eleventh cranial nerve).
MW, YH
10060929
accessory nerve disorder AE
CTCAE: E12573
NCIt: C26953
a cranial neuropathy AE that has involvement of the hypoglossal nerve (twelfth cranial nerve).
MW, YH
10061212
hypoglossal nerve disorder AE
CTCAE: E12692
NCIt: C26954
a hemorrhage AE that has bleeding from the pharynx.
MW, YH
10055315
pharyngeal hemorrhage AE
CTCAE: E13460
NCIt: C26986
a distal neuropathy AE that has regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand.
MW, YH
10065417
brachial plexopathy AE
CTCAE: E12601
NCIt: C27194
a cranial neuropathy AE that has involvement of the acoustic nerve (eighth cranial nerve)
MW, YH
10000521
acoustic nerve disorder NOS AE
CTCAE: E12577
NCIt: C27207
a cranial neuropathy AE that has involvement of the olfactory nerve (first cranial nerve).
MW, YH
10056388
olfactory nerve disorder AE
CTCAE: E12755
NCIt: C27210
a cranial neuropathy AE that has involvement of the glossopharyngeal nerve (ninth cranial nerve).
MW, YH
10061185
glossopharyngeal nerve disorder AE
CTCAE: E12672
NCIt: C27211
a cranial neuropathy AE that has involvement of the vagus nerve (tenth cranial nerve).
MW, YH
10061403
vagus nerve disorder AE
CTCAE: E12845
NCIt: C27591
a cranial neuropathy AE that has involvement of the abducens nerve (sixth cranial nerve).
MW, YH
10053662
abducens nerve disorder AE
CTCAE: E12569
NCIt: C27593
a cranial neuropathy AE that has involvement of the facial nerve (seventh cranial nerve).
MW, YH
10061457
facial nerve disorder AE
CTCAE: E12668
NCIt: C27594
a cranial neuropathy AE that has involvement of the oculomotor nerve (third cranial nerve).
MW, YH
10053661
oculomotor nerve disorder AE
CTCAE: E12751
NCIt: C27598
a sensory neuropathy AE that has distortion of sensory perception, resulting in an abnormal and unpleasant sensation.
MW, YH
10062872
dysesthesia AE
CTCAE: E12639
NCIt: C28246
a pain AE that has painful or difficult coitus.
MW, YH
10013941
dyspareunia AE
CTCAE: E13081
NCIt: C2997
a bone disorder AE that has non-neoplastic overgrowth of bone.
MW, YH
10015688
exostosis AE
CTCAE: E12404
NCIt: C3029
an endocrine system AE that has excessive development of the breasts in males.
MW, YH
10018801
gynecomastia AE
CTCAE: E13115
NCIt: C3073
a brain edema AE that has an abnormal increase of cerebrospinal fluid in the ventricles of the brain.
MW, YH
10020508
hydrocephalus AE
CTCAE: E12682
NCIt: C3111
an edema AE that has excessive fluid collection in tissues that causes swelling.
MW, YH
10025233
lymphedema AE
CTCAE: E13802
NCIt: C3207
a menstrual disorder AE that has the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age.
MW, YH
10027308
menopause AE
CTCAE: E13750
NCIt: C3231
a physical examination result abnormal AE that is having a high amount of body fat.
MW, YH
10029883
obesity AE
CTCAE: E12361
NCIt: C3283
a lung inflammation AE that has progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery.
MW, YH
10001409
adult respiratory distress syndrome AE
CTCAE: E13299
NCIt: C3353
a cardiovascular AE that has obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache.
MW, YH
Superior vena cava syndrome AE
CTCAE: E13819
NCIt: C3396
a menstrual disorder AE that has abnormally painful abdominal cramps during menses.
MW, YH
10013934
dysmenorrhea AE
CTCAE: E13077
NCIt: C34559
a behavior and neurological AE that has an exaggerated feeling of well-being which is disproportionate to events and stimuli.
MW, YH
10015533
euphoria AE
CTCAE: E12915
NCIt: C34598
a pain AE that has marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip.
MW, YH
10016750
flank pain AE
CTCAE: E12414
NCIt: C34615
a metabolic disorder AE that has an inability to properly metabolize glucose.
MW, YH
10052426
glucose intolerance AE
CTCAE: E12264
NCIt: C34646
an urine abnormality AE that has laboratory test results that indicate the presence of free hemoglobin in the urine.
MW, YH
10019489
hemoglobinuria AE
CTCAE: E13006
NCIt: C34677
a sweating AE that has reduced sweating.
MW, YH
10021013
hypohidrosis AE
CTCAE: E13652
NCIt: C34718
a bone disorder AE that has an abnormal increase in the curvature of the thoracic portion of the spine.
MW, YH
10023509
kyphosis AE
CTCAE: E12447
NCIt: C34754
a bone disorder AE that has an abnormal increase in the curvature of the lumbar portion of the spine.
MW, YH
10024842
lordosis AE
CTCAE: E12451
NCIt: C34787
a male reproductive system AE that has a decrease in the number of spermatozoa in the semen.
MW, YH
10030300
oligospermia AE
CTCAE: E13141
NCIt: C34860
a necrosis AE that has necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure.
MW, YH
10066480
avascular necrosis AE
CTCAE: E12382
NCIt: C34880
an inflammation AE that has inflammation of the skin characterized by the presence of bullae which are filled with fluid.
MW, YH
10006556
bullous dermatitis AE
CTCAE: E13617
NCIt: C35149
a speech disorder AE that has impairment of verbal communication skills, often resulting from brain damage.
MW, YH
10013951
dysphasia AE
CTCAE: E12646
NCIt: C35546
a female reproductive system AE that has a narrowing of the vaginal canal.
MW, YH
10053496
vaginal stricture AE
CTCAE: E13290
NCIt: C36064
a metabolism, endocrine, and exocrine system AE that has abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues.
MW, YH
10001680
alkalosis AE
CTCAE: E12247
NCIt: C37909
a gastrointestinal disorder AE that has repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm.
MW, YH
10020039
Hiccups AE
CTCAE: E13380
NCIt: C37966
an urine abnormality AE that has laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin.
MW, YH
10037032
proteinuria AE
CTCAE: E13008
NCIt: C38012
an inflammation AE that has generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area.
MW, YH
10015277
erythroderma AE
CTCAE: E13633
NCIt: C39646
a syndrome AE that has dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination.
MW, YH
10063636
pyramidal tract syndrome AE
CTCAE: E12780
NCIt: C43245
a brain edema AE that has swelling due to an excessive accumulation of fluid in the brain.
MW, YH
10014217
edema cerebral AE
CTCAE: E12650
NCIt: C4909
a tumor AE that has development of a malignancy most probably as a result of treatment for a previously existing malignancy.
MW, YH
10049737
treatment related secondary malignancy AE
CTCAE: E12561
NCIt: C4969
a hemorrhage AE that has bleeding from the cranium.
MW, YH
10022763
intracranial hemorrhage AE
CTCAE: E12696
NCIt: C50438
a death AE that has death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation.
MW, YH
10016479
fetal death AE
CTCAE: E12855
NCIt: C50620
a ischemia AEE that has a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.
MW, YH
10044391
transient ischemic attacks AE
CTCAE: E12834
NCIt: C50781
afemale reproductive system AE that has vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years.
MW, YH
10046901
vaginal discharge AE
CTCAE: E13251
NCIt: C50795
a sensory capability AE that has a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve.
MW, YH
10047166
vasovagal reaction AE
CTCAE: E12851
NCIt: C50798
apregnancy AE that has delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation.
MW, YH
早产
10036595
premature delivery AE
CTCAE: E12867
NCIt: C50917
a psychiatric disorder AE that has excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood.
MW, YH
10026749
mania AE
CTCAE: E12936
NCIt: C61374
a hair growth abnormal AE that has the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen)
MW, YH
10020112
hirsutism AE
CTCAE: E13642
NCIt: C61444
a necrosis AE that has a necrotic process occurring in the bone of the mandible.
MW, YH
10064658
osteonecrosis of jaw AE
CTCAE: E12502
NCIt: C63924
a necrosis AE that has a necrotic process occurring in the soft tissues of the abdominal wall.
MW, YH
10065775
abdominal soft tissue necrosis AE
CTCAE: E12369
NCIt: C78165
a metabolic disorder AE that has an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches.
MW, YH
10001598
alcohol intolerance AE
CTCAE: E12242
NCIt: C78167
a psychiatric disorder AE that has an inability to achieve orgasm.
MW, YH
10002652
anorgasmia AE
CTCAE: E12880
NCIt: C78177
an urinary system AE that has a rupture in the bladder wall.
MW, YH
10063575
bladder perforation AE
CTCAE: E12979
NCIt: C78208
an urinary system AE that has a sudden and involuntary contraction of the bladder wall.
MW, YH
10048994
bladder spasm AE
CTCAE: E12984
NCIt: C78210
a hemorrhage AE that is bleeding from the bronchial wall and/or lung parenchyma.
MW, YH
10065746
bronchopulmonary hemorrhage AE
CTCAE: E13346
NCIt: C78224
a respiratory system AE that has blockage of a bronchus passage, most often by bronchial secretions and exudates.
MW, YH
10006440
bronchial obstruction AE
CTCAE: E13328
NCIt: C78225
a respiratory system AE that has a narrowing of the bronchial tube.
MW, YH
10063524
bronchial stricture AE
CTCAE: E13334
NCIt: C78226
a necrosis AE that has a necrotic process occurring in the brain and/or spinal cord.
MW, YH
10065784
central nervous system necrosis AE
CTCAE: E12605
NCIt: C78236
a pain AE that has marked discomfort sensation in the chest wall region.
MW, YH
10008496
chest wall pain AE
CTCAE: E12400
NCIt: C78238
a cystitis AE that has inflammation of the bladder which is not caused by an infection of the urinary tract.
MW, YH
10063057
cystitis noninfective AE
CTCAE: E12994
NCIt: C78250
a psychiatric disorder AE that has sexual dysfunction characterized by a delay in climax.
MW, YH
10057066
delayed orgasm AE
CTCAE: E12895
NCIt: C78252
a male reproductive system AE that has problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation.
MW, YH
10014326
ejaculation disorder AE
CTCAE: E13085
NCIt: C78264
a muscular weakness AE that has a reduction in the strength of the facial muscles.
MW, YH
10051272
facial muscle weakness AE
CTCAE: E12664
NCIt: C78290
a female reproductive system AE that has blockage of the normal flow of the contents in the fallopian tube.
MW, YH
10065789
fallopian tube obstruction AE
CTCAE: E13092
NCIt: C78293
a female reproductive system AE that has a narrowing of the fallopian tube lumen.
MW, YH
10065791
fallopian tube stenosis AE
CTCAE: E13096
NCIt: C78295
a connective tissue disorder AE that has shrinking of adipose tissue.
MW, YH
10016241
fat atrophy AE
CTCAE: E13638
NCIt: C78297
a fistula AE that has an abnormal communication between a female reproductive system organ and another organ or anatomic site.
MW, YH
10061149
female genital tract fistula AE
CTCAE: E13102
NCIt: C78298
an endocrine system AE that has the development of secondary female sex characteristics in males due to extrinsic factors.
MW, YH
10054382
feminization acquired AE
CTCAE: E13108
NCIt: C78299
a connective tissue disorder AE that has fibrotic degeneration of the deep connective tissues.
MW, YH
10065799
fibrosis deep connective tissue AE
CTCAE: E12408
NCIt: C78301
a muscular weakness AE that has a reduction in the strength of muscles in multiple anatomic sites.
MW, YH
10062572
generalized muscle weakness AE
CTCAE: E12418
NCIt: C78323
a musculoskeletal and connective tissue AE that has stature that is smaller than normal as expected for age.
MW, YH
10018761
growth suppression AE
CTCAE: E12422
NCIt: C78328
a necrosis AE that has a necrotic process occurring in the soft tissues of the head.
MW, YH
10065779
head soft tissue necrosis AE
CTCAE: E12426
NCIt: C78331
a female reproductive system AE that has the presence of blood in a fallopian tube.
MW, YH
10060602
hematosalpinx AE
CTCAE: E13119
NCIt: C78332
a sleep disorder AE that has characterized by excessive sleepiness during the daytime.
MW, YH
10020765
hypersomnia AE
CTCAE: E12688
NCIt: C78346
a homeostasis AE that has accumulation of iron in the tissues.
MW, YH
10065973
iron overload AE
CTCAE: E12350
NCIt: C78393
an ischemia AE that has a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage.
MW, YH
10023030
ischemia cerebrovascular AE
CTCAE: E12702
NCIt: C78394
a cranial neuropathy AE that has involvement of the trochlear nerve (fourth cranial nerve).
MW, YH
10065836
IVth nerve disorder AE
CTCAE: E12705
NCIt: C78395
a joint disorder AE that has a decrease in flexibility of a cervical spine joint.
MW, YH
10065796
joint range of motion decreased cervical spine AE
CTCAE: E12439
NCIt: C78404
a joint disorder AE that has a decrease in flexibility of a lumbar spine joint.
MW, YH
10065800
joint range of motion decreased lumbar spine AE
CTCAE: E12443
NCIt: C78405
a fistula AE that has an abnormal communication between the larynx and another organ or anatomic site.
MW, YH
10065786
laryngeal fistula AE
CTCAE: E13399
NCIt: C78410
a hemorrhage AE that has bleeding from the larynx.
MW, YH
10065759
laryngeal hemorrhage AE
CTCAE: E13405
NCIt: C78411
an inflammation AE that has an inflammation involving the mucous membrane of the larynx.
MW, YH
10065880
laryngeal mucositis AE
CTCAE: E13415
NCIt: C78412
a respiratory system AE that has blockage of the laryngeal airway.
MW, YH
10059639
laryngeal obstruction AE
CTCAE: E13421
NCIt: C78413
a libido disorder AE that has a decrease in sexual desire.
MW, YH
10024419
libido decreased AE
CTCAE: E12929
NCIt: C78432
a libido disorder AE that has an increase in sexual desire.
MW, YH
10024421
libido increased AE
CTCAE: E12932
NCIt: C78433
a skin AE that has hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.
MW, YH
10062315
lipohypertrophy AE
CTCAE: E13657
NCIt: C78436
an immune system AE that has the loss of lymph fluid into the surrounding tissue or body cavity.
MW, YH
10065773
lymph leakage AE
CTCAE: E13797
NCIt: C78439
an immune system AE that has a cystic lesion containing lymph.
MW, YH
10048642
lymphocele AE
CTCAE: E13806
NCIt: C78442
a hemorrhage AE that has bleeding from the mediastinum.
MW, YH
10056356
mediastinal hemorrhage AE
CTCAE: E13444
NCIt: C78443
a movement disorder AE that has uncontrolled and purposeless movements.
MW, YH
10028041
movements involuntary AE
CTCAE: E12728
NCIt: C78453
a muscular weakness AE that has a reduction in the strength of the muscles on the left side of the body.
MW, YH
10065780
muscle weakness left-sided AE
CTCAE: E12455
NCIt: C78455
a muscular weakness AE that has a reduction in the strength of the lower limb muscles.
MW, YH
10065776
muscle weakness lower limb AE
CTCAE: E12459
NCIt: C78456
a muscular weakness AE that has a reduction in the strength of the muscles on the right side of the body.
MW, YH
10065794
muscle weakness right-sided AE
CTCAE: E12463
NCIt: C78457
a muscular weakness AE that has a reduction in the strength of the trunk muscles.
MW, YH
10065795
muscle weakness trunk AE
CTCAE: E12467
NCIt: C78458
a muscular weakness AE that has a reduction in the strength of the upper limb muscles.
MW, YH
10065895
muscle weakness upper limb AE
CTCAE: E12471
NCIt: C78459
a musculoskeletal and connective tissue AE that has a malformation of the musculoskeletal system.
MW, YH
10065783
musculoskeletal deformity AE
CTCAE: E12481
NCIt: C78488
a nail AE that has a change in the color of the nail plate.
MW, YH
10028691
nail discoloration AE
CTCAE: E13661
NCIt: C78492
a nail AE that has loss of all or a portion of the nail.
MW, YH
10049281
nail loss AE
CTCAE: E13663
NCIt: C78494
a nail AE that has vertical or horizontal ridges on the nails.
MW, YH
10062283
nail ridging AE
CTCAE: E13666
NCIt: C78499
a necrosis AE that has a necrotic process occurring in the soft tissues of the neck.
MW, YH
10065781
neck soft tissue necrosis AE
CTCAE: E12497
NCIt: C78502
a female reproductive system AE that has a malformation of the nipple.
MW, YH
10065823
nipple deformity AE
CTCAE: E13138
NCIt: C78503
a hemorrhage AE that has bleeding from the ovary.
MW, YH
10065763
ovarian hemorrhage AE
CTCAE: E13145
NCIt: C78511
a female reproductive system AE that is tearing or disruption of the ovarian tissue.
MW, YH
10033279
ovarian rupture AE
CTCAE: E13151
NCIt: C78513
a pain AE that has marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.
MW, YH
10033314
ovulation pain AE
CTCAE: E13157
NCIt: C78514
a muscular weakness AE that has a reduction in the strength of the muscles of the pelvic floor.
MW, YH
10064026
pelvic floor muscle weakness AE
CTCAE: E13161
NCIt: C78524
a necrosis AE that has a necrotic process occurring in the soft tissues of the pelvis.
MW, YH
10065793
pelvic soft tissue necrosis AE
CTCAE: E12516
NCIt: C78525
a pain AE that has marked discomfort sensation in the penis.
MW, YH
10034310
penile pain AE
CTCAE: E13171
NCIt: C78527
a psychiatric disorder AE that has a conspicuous change in a person's behavior and thinking.
MW, YH
10034719
personality change AE
CTCAE: E12942
NCIt: C78548
a fistula AE that has an abnormal communication between the pharynx and another organ or anatomic site.
MW, YH
10034825
pharyngeal fistula AE
CTCAE: E13454
NCIt: C78551
an inflammation AE that has an inflammation involving the mucous membrane of the pharynx.
MW, YH
10065881
pharyngeal mucositis AE
CTCAE: E13466
NCIt: C78553
a necrosis AE that has a necrotic process occurring in the pharynx.
MW, YH
10065706
pharyngeal necrosis AE
CTCAE: E13472
NCIt: C78554
a respiratory system AE that has a narrowing of the pharyngeal airway.
MW, YH
10050028
pharyngeal stenosis AE
CTCAE: E13476
NCIt: C78555
a hemorrhage AE that has bleeding from the prostate gland.
MW, YH
10055325
prostatic hemorrhage AE
CTCAE: E13181
NCIt: C78572
a prostatic disorder AE that has compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder).
MW, YH
10055026
prostatic obstruction AE
CTCAE: E13187
NCIt: C78573
a pain AE that has a sensation of marked discomfort in the prostate gland.
MW, YH
10036968
prostatic pain AE
CTCAE: E13191
NCIt: C78574
a psychiatric disorder AE that has personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor.
MW, YH
10037234
psychosis AE
CTCAE: E12954
NCIt: C78576
a fistula AE that has an abnormal communication between the lung and another organ or anatomic site.
MW, YH
10065873
pulmonary fistula AE
CTCAE: E13533
NCIt: C78577
an inflammation AE that has inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root.
MW, YH
10061928
radiculitis AE
CTCAE: E12786
NCIt: C78581
a nervous system AE that has paralysis of the recurrent laryngeal nerve.
MW, YH
10038130
recurrent laryngeal nerve palsy AE
CTCAE: E12792
NCIt: C78592
a renal calculus AE that has paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones.
MW, YH
10038419
renal colic AE
CTCAE: E13024
NCIt: C78593
a hemorrhage AE that has bleeding from the kidney.
MW, YH
10038463
renal hemorrhage AE
CTCAE: E13028
NCIt: C78594
a syndrome AE that has weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid.
MW, YH
10038921
retinoic acid syndrome AE
CTCAE: E13554
NCIt: C78597
a bone disorder AE that has a malformed, lateral curvature of the spine.
MW, YH
10039722
scoliosis AE
CTCAE: E12521
NCIt: C78603
a pain AE that has marked discomfort sensation in the scrotal area.
MW, YH
10039757
scrotal pain AE
CTCAE: E13201
NCIt: C78607
a pain AE that has marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses.
MW, YH
10040747
sinus pain AE
CTCAE: E12810
NCIt: C78609
an induration AE that has an area of hardness in the skin.
MW, YH
10051837
skin induration AE
CTCAE: E13724
NCIt: C78611
a necrosis AE that has a necrotic process occurring in the soft tissues of the lower extremity.
MW, YH
10065777
soft tissue necrosis lower limb AE
CTCAE: E12525
NCIt: C78620
a necrosis AE that has a necrotic process occurring in the soft tissues of the upper extremity.
MW, YH
10065778
soft tissue necrosis upper limb AE
CTCAE: E12530
NCIt: C78621
a hemorrhage AE that has bleeding from the spermatic cord.
MW, YH
10065762
spermatic cord hemorrhage AE
CTCAE: E13205
NCIt: C78623
a male reproductive system AE that has blockage of the normal flow of the contents of the spermatic cord.
MW, YH
10065805
spermatic cord obstruction AE
CTCAE: E13211
NCIt: C78624
a connective tissue disorder AE that has fibrotic degeneration of the superficial soft tissues.
MW, YH
10065798
superficial soft tissue fibrosis AE
CTCAE: E12535
NCIt: C78633
a hemorrhage AE that has bleeding from the testis.
MW, YH
10055347
testicular hemorrhage AE
CTCAE: E13221
NCIt: C78635
a pain AE that has a sensation of marked discomfort in the testis.
MW, YH
10043345
testicular pain AE
CTCAE: E13227
NCIt: C78636
a fistula AE that hasan abnormal communication between the trachea and another organ or anatomic site.
MW, YH
10065787
tracheal fistula AE
CTCAE: E13583
NCIt: C78641
an inflammation AE that has an inflammation involving the mucous membrane of the trachea.
MW, YH
10065900
tracheal mucositis AE
CTCAE: E13589
NCIt: C78644
a respiratory system AE that has a narrowing of the trachea.
MW, YH
10050816
tracheal stenosis AE
CTCAE: E13595
NCIt: C78646
a pain AE that has marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis.
MW, YH
10045158
tumor pain AE
CTCAE: E12565
NCIt: C78656
a musculoskeletal and connective tissue AE that hasa discrepancy between the lengths of the lower or upper extremities.
MW, YH
10065738
unequal limb length AE
CTCAE: E12545
NCIt: C78657
an urine abnormality AE that has a change in the color of the urine.
MW, YH
10046628
urine discoloration AE
CTCAE: E13065
NCIt: C78678
a fistula AE that has an abnormal communication between the uterus and another organ or anatomic site.
MW, YH
10065811
uterine fistula AE
CTCAE: E13231
NCIt: C78685
an urinary system AE that has blockage of the uterine outlet.
MW, YH
10065928
uterine obstruction AE
CTCAE: E13243
NCIt: C78693
a pain AE that has a sensation of marked discomfort in the uterus.
MW, YH
10046809
uterine pain AE
CTCAE: E13247
NCIt: C78694
a female reproductive system AE that has an uncomfortable feeling of itching and burning in the vagina.
MW, YH
10046904
vaginal dryness AE
CTCAE: E13254
NCIt: C78699
a female reproductive system AE that has blockage of vaginal canal.
MW, YH
10065817
vaginal obstruction AE
CTCAE: E13276
NCIt: C78700
a pain AE that has a sensation of marked discomfort in the vagina.
MW, YH
10046937
vaginal pain AE
CTCAE: E13280
NCIt: C78701
a female reproductive system AE that has a rupture in the vaginal wall.
MW, YH
10065818
vaginal perforation AE
CTCAE: E13284
NCIt: C78702
a female reproductive system AE that hasinvoluntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse.
MW, YH
10046947
vaginismus AE
CTCAE: E13295
NCIt: C78703
an ischemia AE that has a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery.
MW, YH
10054692
visceral arterial ischemia AE
CTCAE: E13843
NCIt: C78712
a skin AE that has an abnormal body smell resulting from the growth of bacteria on the body.
MW, YH
10005901
body odor AE
CTCAE: E13614
NCIt: C79542
a fistula AE that has an abnormal communication between the bronchus and another organ or anatomic site.
MW, YH
10006437
bronchial fistula AE
CTCAE: E13322
NCIt: C79543
a nervous system AE that has an abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness.
MW, YH
10015832
extrapyramidal disorder AE
CTCAE: E12658
NCIt: C79593
a hair growth abnormal AE that has hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race.
MW, YH
10020864
hypertrichosis AE
CTCAE: E13649
NCIt: C79597
a female reproductive system AE that has disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males.
MW, YH
10061261
lactation disorder AE
CTCAE: E13129
NCIt: C79606
a respiratory system AE that has a narrowing of the laryngeal airway.
MW, YH
10023862
laryngeal stenosis AE
CTCAE: E13427
NCIt: C79608
a nervous system AE that has neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges.
MW, YH
10027198
meningismus AE
CTCAE: E12722
NCIt: C79694
a pain AE that has marked discomfort related to a limb or an organ that is removed from or is not physically part of the body.
MW, YH
10056238
phantom pain AE
CTCAE: E12774
NCIt: C79703
a pain AE that has marked discomfort sensation in the skin covering the top and the back of the head.
MW, YH
10049120
scalp pain AE
CTCAE: E13704
NCIt: C79716
a pregnancy AE that has an unexpected pregnancy at the time of conception.
MW, YH
10045542
unintended pregnancy AE
CTCAE: E12872
NCIt: C79801
an urinary system AE that has blockage of the normal flow of contents of the urinary tract.
MW, YH
10061574
urinary tract obstruction AE
CTCAE: E13052
NCIt: C79805
a fistula AE that has an abnormal communication between the vagina and another organ or anatomic site.
MW, YH
10065813
vaginal fistula AE
CTCAE: E13258
NCIt: C79847
a fistula AE that has an abnormal communication between any part of the urinary system and another organ or anatomic site.
MW, YH
10065368
urinary fistula AE
CTCAE: E13034
NCIt: C79850
a male reproductive system AE that has laboratory test results that indicate complete absence of spermatozoa in the semen.
MW, YH
10003883
azoospermia AE
CTCAE: E13067
NCIt: C80076
a renal failure AE that has gradual and usually permanent loss of kidney function resulting in renal failure.
MW, YH
10064848
chronic kidney disease AE
CTCAE: E12988
NCIt: C80078
a behavior and neurological AE that has a deterioration in the ability to concentrate.
MW, YH
10010250
concentration impairment AE
CTCAE: E12621
NCIt: C80081
a fetal disorder AE that has inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight.
MW, YH
10054746
fetal growth retardation AE
CTCAE: E12857
NCIt: C80083
a menstrual disorder AE that has ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive.
MW, YH
10036601
premature menopause AE
CTCAE: E13179
NCIt: C80099
a tumor AE that has leukemia arising as a result of the mutagenic effect of chemotherapy agents.
MW, YH
10048293
leukemia secondary to oncology chemotherapy AE
CTCAE: E12549
NCIt: C80691
a fistula AE that has an abnormal communication between a bronchus and the pleural cavity.
MW, YH
10053481
bronchopleural fistula AE
CTCAE: E13340
NCIt: C80694
a pain AE that has a sensation of marked discomfort in the urinary tract.
MW, YH
10062225
urinary tract pain AE
CTCAE: E13058
NCIt: C83493
a female reproductive system AE that has underdevelopment of the breast.
MW, YH
10006179
breast atrophy AE
CTCAE: E13069
NCIt: C83494
a medical intervention that refers to any series of pre-defined steps that should be followed to achieve a desired result.
YH, SS
WEB: http://www.wisegeekhealth.com/what-is-the-difference-between-a-surgery-and-a-procedure.htm
medical procedure
an AE that occurs in an incision site.
YH, SS
incision site AE
a medical intervention site that is used for incision for a surgery.
YH, SS
incision site
a hymphedema AE that has trace thickening or faint discoloration
YH, MW
Grade 1 lymphedema AE
CTCAE: E13803
a hymphedema AE that has marked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL
YH, MW
Grade 2 lymphedema AE
CTCAE: E13804
a superior vena cava syndrome AE that has asymptomatic; incidental finding of SVC thrombosis
YH, MW
Grade 1 superior vena cava syndrome AE
CTCAE: E13820
a superior vena cava syndrome AEthat has symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy)
YH, MW
Grade 2 superior vena cava syndrome AE
CTCAE: E13821
a superior vena cava syndrome AE that has severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting)
YH, MW
Grade 3 superior vena cava syndrome AE
CTCAE: E13822
a superior vena cava syndrome AE that has life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery)
YH, MW
Grade 4 superior vena cava syndrome AE
CTCAE: E13823
a thromboembolic event AE that has venous thrombosis (e.g., superficial thrombosis)
YH, MW
Grade 1 thromboembolic event AE
CTCAE: E13826
a thromboembolic event AE that has venous thrombosis (e.g., uncomplicated deep vein thrombosis), medical intervention indicated
YH, MW
Grade 2 thromboembolic event AE
CTCAE: E13827
a thromboembolic event AE that has thrombosis (e.g., uncomplicated pulmonary embolism [venous], non-embolic cardiac mural [arterial] thrombus), medical intervention indicated
YH, MW
Grade 3 thromboembolic event AE
CTCAE: E13828
a thromboembolic event AE that has life-threatening (e.g., pulmonary embolism, cerebrovascular event, arterial insufficiency); hemodynamic or neurologic instability; urgent intervention indicated
YH, MW
Grade 4 thromboembolic event AE
CTCAE: E13829
a visceral arterial ischemia AE that has brief (<24 hrs) episode of ischemia managed medically and without permanent deficit
YH, MW
Grade 2 visceral arterial ischemia AE
CTCAE: E13844
a visceral arterial ischemia AE that has prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated
YH, MW
Grade 3 visceral arterial ischemia AE
CTCAE: E13845
a menopause AE that the menopause occurres at age 46 - 53 years of age
YH, MW
Grade 1 menopause AE
CTCAE: E13751
a menopause AE that the menopause occurres at age 40 - 45 years of age
YH, MW
Grade 2 menopause AE
CTCAE: E13752
a menopause AE that the menopause occurres before age 40 years of age
YH, MW
Grade 3 menopause AE
CTCAE: E13753
a body odor AE that has mild odor; physician intervention not indicated; self care interventions
YH, MW
Grade 1 body odor AE
CTCAE: E13615
a body odor AE that has pronounced odor; psychosocial impact; patient seeks medical intervention
YH, MW
Grade 2 body odor AE
CTCAE: E13616
a bullous AE that has asymptomatic; blisters covering <10% BSA
YH, MW
Grade 1 bullous dermatitis AE
CTCAE: E13618
a bullous AE that has blisters covering 10 - 30% BSA; painful blisters; limiting instrumental ADL
YH, MW
Grade 2 bullous dermatitis AE
CTCAE: E13619
a bullous AE that has blisters covering >30% BSA; limiting self care ADL
YH, MW
Grade 3 bullous dermatitis AE
CTCAE: E13620
a bullous AE that has blisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated
YH, MW
Grade 4 bullous dermatitis AE
CTCAE: E13621
an erythroderma AE that has erythema covering >90% BSA without associated symptoms; limiting instrumental ADL
YH, MW
Grade 2 erythroderma AE
CTCAE: E13634
an erythroderma AE that has erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL
YH, MW
Grade 3 erythroderma AE
CTCAE: E13635
an erythroderma AE that has erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated
YH, MW
Grade 4 erythroderma AE
CTCAE: E13636
a fat atrophy AE that is covering <10% BSA and asymptomatic
YH, MW
Grade 1 fat atrophy AE
CTCAE: E13639
a fat atrophy AE that is covering 10 - 30% BSA and associated with erythema or tenderness; limiting instrumental ADL
YH, MW
Grade 2 fat atrophy AE
CTCAE: E13640
a fat atrophy AE that is covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL
YH, MW
Grade 3 fat atrophy AE
CTCAE: E13641
a hirsutism AE that is In women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair
YH, MW
Grade 1 hirsutism AE
CTCAE: E13643
a hirsutism AE that In women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact
YH, MW
Grade 2 hirsutism AE
CTCAE: E13644
a hypertrichosis AE that has increased in length, thickness or density of hair. The patient is either able to camouflage by periodic shaving or removal of hairs or is not concerned enough about the overgrowth to use any form of hair removal
YH, MW
Grade 1 hypertrichosis AE
CTCAE: E13650
a hypertrichosis AE that has increased in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact
YH, MW
Grade 2 hypertrichosis AE
CTCAE: E13651
a hypertrichosis AE that has increased in body temperature; limiting self care ADL
YH, MW
Grade 3 hypohidrosis AE
CTCAE: E13654
a hypertrichosis AE that has heat stroke
YH, MW
Grade 4 hypohidrosis AE
CTCAE: E13655
a lipohypertrophy AE that has asymptomatic and covering <10% BSA
YH, MW
Grade 1 lipohypertrophy AE
CTCAE: E13658
a lipohypertrophy AE that covers 10 - 30% BSA and associated tenderness; limiting instrumental ADL
YH, MW
Grade 2 lipohypertrophy AE
CTCAE: E13659
a lipohypertrophy AE that covers >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL
YH, MW
Grade 3 lipohypertrophy AE
CTCAE: E13660
a nail loss AE that has asymptomatic separation of the nail bed from the nail plate or nail loss
YH, MW
Grade 1 nail loss AE
CTCAE: E13664
a nail loss AE that has symptomatic separation of the nail bed from the nail plate or nail loss; limiting instrumental ADL
YH, MW
Grade 2 nail loss AE
CTCAE: E13665
a rash acneiform AE that has papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness
YH, MW
Grade 1 rash acneiform AE
CTCAE: E13695
a rash acneiform AE that has papules and/or pustules covering 10 - 30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL
YH, MW
Grade 2 rash acneiform AE
CTCAE: E13696
a rash acneiform AE that has papules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self care ADL; associated with local superinfection with oral antibiotics indicated
YH, MW
Grade 3 rash acneiform AE
CTCAE: E13697
a rash acneiform AE that has papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences
YH, MW
Grade 4 rash acneiform AE
CTCAE: E13698
a rash maculopapular AE that has macules/papules covering <10% BSA with or without symptoms (e.g., pruritus, burning, tightness)
YH, MW
Grade 1 rash maculo-papular AE
CTCAE: E13701
a rash maculopapular AE that has macules/papules covering 10 - 30% BSA with or without symptoms (e.g., pruritus, burning, tightness); limiting instrumental ADL
YH, MW
Grade 2 rash maculo-papular AE
CTCAE: E13702
a rash maculopapular AE that has macules/papules covering >30% BSA with or without associated symptoms; limiting self care ADL
YH, MW
Grade 3 rash maculo-papular AE
CTCAE: E13703
a skin induration AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)
YH, MW
Grade 1 skin induration AE
CTCAE: E13725
a skin induration AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL
YH, MW
Grade 2 skin induration AE
CTCAE: E13726
a skin induration AE that has severe induration, unable to slide or pinch skin; limiting joint movement or orifice (e.g., mouth, anus); limiting self care ADL
YH, MW
Grade 3 skin induration AE
CTCAE: E13727
a skin induration AE that has generalized; associated with signs or symptoms of impaired breathing or feeding
YH, MW
Grade 4 skin induration AE
CTCAE: E13728
a bronchial fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL
YH, MW
Grade 2 bronchial fistula AE
CTCAE: E13324
a bronchial fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
YH, MW
Grade 3 bronchial fistula AE
CTCAE: E13325
a bronchial fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated
YH, MW
Grade 4 bronchial fistula AE
CTCAE: E13326
a bronchial obstruction AE that has symptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators)
YH, MW
Grade 2 bronchial obstruction AE
CTCAE: E13330
a bronchial obstruction AE that has shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)
YH, MW
Grade 3 bronchial obstruction AE
CTCAE: E13331
a bronchial stricture AE that AE symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators)
YH, MW
Grade 2 bronchial stricture AE
CTCAE: E13336
a bronchial stricture AE that AE shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement)
YH, MW
Grade 3 bronchial stricture AE
CTCAE: E13337
a bronchopleural fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
YH, MW
Grade 3 bronchopleural fistula AE
CTCAE: E13343
a bronchopleural fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated
YH, MW
Grade 4 bronchopleural fistula AE
CTCAE: E13344
a laryngeal fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL
YH, MW
Grade 2 laryngeal fistula AE
CTCAE: E13401
a laryngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
YH, MW
Grade 3 laryngeal fistula AE
CTCAE: E13402
a laryngeal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies)
YH, MW
Grade 4 laryngeal fistula AE
CTCAE: E13403
a laryngeal hemorrhage AE that has mild cough or trace hemoptysis; laryngoscopic findings
YH, MW
Grade 1 laryngeal hemorrhage AE
CTCAE: E13406
a laryngeal inflammation AE that has mild sore throat; raspy voice
YH, MW
Grade 1 laryngeal inflammation AE
CTCAE: E13412
a laryngeal inflammation AE that has moderate sore throat; analgesics indicated
YH, MW
Grade 2 laryngeal inflammation AE
CTCAE: E13413
a laryngeal inflammation AE that has severe throat pain; endoscopic intervention indicated
YH, MW
Grade 3 laryngeal inflammation AE
CTCAE: E13414
a laryngeal mucositis AE that has endoscopic findings only; mild discomfort with normal intake
YH, MW
Grade 1 laryngeal mucositis AE
CTCAE: E13416
a laryngeal mucositis AE that has moderate discomfort; altered oral intake
YH, MW
Grade 2 laryngeal mucositis AE
CTCAE: E13417
a laryngeal mucositis AE that has severe pain; severely altered eating/swallowing; medical intervention indicated
YH, MW
Grade 3 laryngeal mucositis AE
CTCAE: E13418
a laryngeal mucositis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
YH, MW
Grade 4 laryngeal mucositis AE
CTCAE: E13419
a laryngeal obstruction AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL
YH, MW
Grade 2 laryngeal obstruction AE
CTCAE: E13423
a laryngeal obstruction AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)
YH, MW
Grade 3 laryngeal obstruction AE
CTCAE: E13424
a laryngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids)
YH, MW
Grade 2 laryngeal stenosis AE
CTCAE: E13429
a laryngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)
YH, MW
Grade 3 laryngeal stenosis AE
CTCAE: E13430
a laryngopharyngeal dysesthesia AE that has moderate symptoms; mild anxiety, but no dyspnea; short duration of observation and or anxiolytic indicated; limiting instrumental ADL
YH, MW
Grade 2 laryngopharyngeal dysesthesia AE
CTCAE: E13435
a laryngopharyngeal dysesthesia AE that has severe symptoms; dyspnea and swallowing difficulty; limiting self care ADL
YH, MW
Grade 3 laryngopharyngeal dysesthesia AE
CTCAE: E13436
a laryngospasm AE that has transient episode; intervention not indicated
YH, MW
Grade 2 laryngospasm AE
CTCAE: E13440
a laryngospasm AE that has recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage)
YH, MW
Grade 3 laryngospasm AE
CTCAE: E13441
a laryngospasm AE that has persistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection)
YH, MW
Grade 4 laryngospasm AE
CTCAE: E13442
a pharyngeal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL
YH, MW
Grade 2 pharyngeal fistula AE
CTCAE: E13456
a pharyngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
YH, MW
Grade 3 pharyngeal fistula AE
CTCAE: E13457
a pharyngeal mucositis AE that has endoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated
YH, MW
Grade 1 pharyngeal mucositis AE
CTCAE: E13467
a pharyngeal mucositis AE that has moderate pain and analgesics indicated; altered oral intake; limiting instrumental ADL
YH, MW
Grade 2 pharyngeal mucositis AE
CTCAE: E13468
a pharyngeal mucositis AE that has severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL
YH, MW
Grade 3 pharyngeal mucositis AE
CTCAE: E13469
a pharyngeal necrosis AE that has inability to aliment adequately by GI tract; tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated
YH, MW
Grade 3 pharyngeal necrosis AE
CTCAE: E13473
a pharyngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL
YH, MW
Grade 2 pharyngeal stenosis AE
CTCAE: E13478
a pharyngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser)
YH, MW
Grade 3 pharyngeal stenosis AE
CTCAE: E13479
a pharyngeal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
YH, MW
Grade 4 pharyngeal stenosis AE
CTCAE: E13480
a pulmonary fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL
YH, MW
Grade 2 pulmonary fistula AE
CTCAE: E13535
a pulmonary fistula AE that has limiting self care ADL; endoscopic stenting or operative intervention indicated
YH, MW
Grade 3 pulmonary fistula AE
CTCAE: E13536
a retinoic acid syndrome AE that has fluid retention; <3 kg of weight gain; intervention with fluid restriction and/or diuretics indicated
YH, MW
Grade 1 retinoic acid syndrome AE
CTCAE: E13555
a sleep apnea AE that has snoring and nocturnal sleep arousal without apneic periods
YH, MW
Grade 1 sleep apnea AE
CTCAE: E13567
a sleep apnea AE that has moderate apnea and oxygen desaturation; excessive daytime sleepiness; medical evaluation indicated; limiting instrumental ADL
YH, MW
Grade 2 sleep apnea AE
CTCAE: E13568
a sleep apnea AE that has oxygen desaturation; associated with hypertension; medical intervention indicated; limiting self care ADL
YH, MW
Grade 3 sleep apnea AE
CTCAE: E13569
a sleep apnea AE that has cardiovascular or neuropsychiatric symptoms; urgent operative intervention indicated
YH, MW
Grade 4 sleep apnea AE
CTCAE: E13570
a tracheal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL
YH, MW
Grade 2 tracheal fistula AE
CTCAE: E13585
a tracheal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure)
YH, MW
Grade 3 tracheal fistula AE
CTCAE: E13586
a tracheal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies)
YH, MW
Grade 4 tracheal fistula AE
CTCAE: E13587
a tracheal mucositis AE that has endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms
YH, MW
Grade 1 tracheal mucositis AE
CTCAE: E13590
a tracheal mucositis AE that has severe pain; hemorrhage or respiratory symptoms; limiting self care ADL
YH, MW
Grade 3 tracheal mucositis AE
CTCAE: E13592
a tracheal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids)
YH, MW
Grade 2 tracheal stenosis AE
CTCAE: E13597
a tracheal stenosis AE that has stridor or respiratory distress limiting self care ADL; endoscopic intervention indicated (e.g., stent, laser)
YH, MW
Grade 3 tracheal stenosis AE
CTCAE: E13598
a tracheal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
YH, MW
Grade 4 tracheal stenosis AE
CTCAE: E13599
an azoospermia AE that has absence of sperm in ejaculate
YH, MW
Grade 3 azoospermia AE
CTCAE: E13068
A breast atrophy AE that has asymmetry >1/3 of breast volume; severe atrophy
YH, MW
Grade 3 breast atrophy AE
CTCAE: E13072
an ejaculation disorder AE that has diminished ejaculation
YH, MW
Grade 1 ejaculation disorder AE
CTCAE: E13086
an ejaculation disorder AE that has anejaculation or retrograde ejaculation
YH, MW
Grade 2 ejaculation disorder AE
CTCAE: E13087
a genital edema AE that has mild swelling or obscuration of anatomic architecture on close inspection
YH, MW
Grade 1 genital edema AE
CTCAE: E13112
a genital edema AE that has readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour
YH, MW
Grade 2 genital edema AE
CTCAE: E13113
a genital edema AE that has lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL
YH, MW
Grade 3 genital edema AE
CTCAE: E13114
a gynecomastia AE that has asymptomatic breast enlargement
YH, MW
Grade 1 gynecomastia AE
CTCAE: E13116
a gynecomastia AE that has symptomatic (e.g., pain or psychosocial impact)
YH, MW
Grade 2 gynecomastia AE
CTCAE: E13117
a hematosalpinx AE that has minimal bleeding identified on imaging study or laparoscopy; intervention not indicated
YH, MW
Grade 1 hematosalpinx AE
CTCAE: E13120
an irregular menstruation AE that has intermittent menses with skipped menses for no more than 1 to 3 months
YH, MW
Grade 1 irregular menstruation AE
CTCAE: E13126
an irregular menstruation AE that has intermittent menses with skipped menses for more than 4 to 6 months
YH, MW
Grade 2 irregular menstruation AE
CTCAE: E13127
an irregular menstruation AE that has persistent amenorrhea for more than 6 months
YH, MW
Grade 3 irregular menstruation AE
CTCAE: E13128
a lactation disorder AE that has mild changes in lactation, not significantly affecting production or expression of breast milk
YH, MW
Grade 1 lactation disorder AE
CTCAE: E13130
a lactation disorder AE that has changes in lactation, significantly affecting breast production or expression of breast milk
YH, MW
Grade 2 lactation disorder AE
CTCAE: E13131
a nipple deformity AE that has asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex
YH, MW
Grade 1 nipple deformity AE
CTCAE: E13139
a nipple deformity AE that has symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex
YH, MW
Grade 2 nipple deformity AE
CTCAE: E13140
an oligospermia AE requires sperm concentration >48 million/mL or motility >68%
YH, MW
Grade 1 oligospermia AE
CTCAE: E13142
an oligospermia AE requires sperm concentration 13 - 48 million/mL or motility 32 - 68%
YH, MW
Grade 2 oligospermia AE
CTCAE: E13143
an oligospermia AE requires sperm concentration <13 million/mL or motility <32%
YH, MW
Grade 3 oligospermia AE
CTCAE: E13144
a testicular disorder AE that has symptomatic but not interfering with urination or sexual activities; intervention not indicated; limiting instrumental ADL
YH, MW
Grade 2 testicular disorder AE
CTCAE: E13217
a testicular disorder AE that has severe symptoms; interfering with urination or sexual function; limiting self care ADL; intervention indicated
YH, MW
Grade 3 testicular disorder AE
CTCAE: E13218
a vaginal discharge AE that has mild vaginal discharge (greater than baseline for patient)
YH, MW
Grade 1 vaginal discharge AE
CTCAE: E13252
a vaginal discharge AE that has moderate to heavy vaginal discharge; use of perineal pad or tampon indicated
YH, MW
Grade 2 vaginal discharge AE
CTCAE: E13253
a bladder spasm AE that has antispasmodics indicated
YH, MW
Grade 2 bladder spasm AE
CTCAE: E12986
a bladder spasm AE that has hospitalization indicated
YH, MW
Grade 3 bladder spasm AE
CTCAE: E12987
a chronic kidney disease AE that requires eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) <LLN - 60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5
YH, MW
Grade 1 chronic kidney disease AE
CTCAE: E12989
a chronic kidney disease AE that requires eGFR or CrCl 59 - 30 ml/min/1.73 m2
YH, MW
Grade 2 chronic kidney disease AE
CTCAE: E12990
a chronic kidney disease AE that requires eGFR or CrCl 29 - 15 ml/min/1.73 m2
YH, MW
Grade 3 chronic kidney disease AE
CTCAE: E12991
a chronic kidney disease AE that requires eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated
YH, MW
Grade 4 chronic kidney disease AE
CTCAE: E12992
a cystitis noninfective AE that has microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence
YH, MW
Grade 1 cystitis noninfective AE
CTCAE: E12995
a cystitis noninfective AE that has moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL
YH, MW
Grade 2 cystitis noninfective AE
CTCAE: E12996
a cystitis noninfective AE that has gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated
YH, MW
Grade 3 cystitis noninfective AE
CTCAE: E12997
a proteinuria AE that requires 1+ proteinuria; urinary protein <1.0 g/24 hrs
YH, MW
Grade 1 proteinuria AE
CTCAE: E13009
a proteinuria AE that requires
YH, MW
Grade 2 proteinuria AE
CTCAE: E13010
a proteinuria AE that requires
YH, MW
Grade 3 proteinuria AE
CTCAE: E13011
a renal calculi AE that has asymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated
YH, MW
Grade 1 renal calculi AE
CTCAE: E13019
a renal calculi AE that has symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated
YH, MW
Grade 2 renal calculi AE
CTCAE: E13020
a renal calculi AE that has hospitalization indicated; IV intervention (e.g., analgesics, antiemetics); elective endoscopic or radiologic intervention indicated
YH, MW
Grade 3 renal calculi AE
CTCAE: E13021
an urinary fistula AE that has noninvasive intervention indicated; urinary or suprapubic catheter placement indicated
YH, MW
Grade 2 urinary fistula AE
CTCAE: E13035
an urinary fistula AE that has limiting self care ADL; elective radiologic, endoscopic or operative intervention indicated; permanent urinary diversion indicated
YH, MW
Grade 3 urinary fistula AE
CTCAE: E13036
an urinary tract obstruction AE that has symptomatic but no hydronephrosis, sepsis or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated
YH, MW
Grade 2 urinary tract obstruction AE
CTCAE: E13054
an urinary tract obstruction AE that has symptomatic and altered organ function (e.g., hydronephrosis, or renal dysfunction); elective radiologic, endoscopic or operative intervention indicated
YH, MW
Grade 3 urinary tract obstruction AE
CTCAE: E13055
a mania AE that has mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep)
YH, MW
Grade 1 mania AE
CTCAE: E12937
a mania AE that has moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene)
YH, MW
Grade 2 mania AE
CTCAE: E12938
a mania AE that has severe manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated
YH, MW
Grade 3 mania AE
CTCAE: E12939
a fetal growth retardation AE that has <10% percentile of weight for gestational age
YH, MW
Grade 2 fetal growth retardation AE
CTCAE: E12858
a fetal growth retardation AE that has <5% percentile of weight for gestational age
YH, MW
Grade 3 fetal growth retardation AE
CTCAE: E12859
a fetal growth retardation AE that has <1% percentile of weight for gestational age
YH, MW
Grade 4 fetal growth retardation AE
CTCAE: E12860
a premature delivery AE that has delivery of a liveborn infant at >34 to 37 weeks gestation
YH, MW
Grade 1 premature delivery AE
CTCAE: E12868
a premature delivery AE that has delivery of a liveborn infant at >28 to 34 weeks gestation
YH, MW
Grade 2 premature delivery AE
CTCAE: E12869
a premature delivery AE that has delivery of a liveborn infant at 24 to 28 weeks gestation
YH, MW
Grade 3 premature delivery AE
CTCAE: E12870
a premature delivery AE that has delivery of a liveborn infant at 24 weeks of gestation or less
YH, MW
Grade 4 premature delivery AE
CTCAE: E12871
a spasticity AE that has mild or slight increase in muscle tone
YH, MW
Grade 1 spasticity AE
CTCAE: E12821
a spasticity AE that has moderate increase in muscle tone and increase in resistance through range of motion
YH, MW
Grade 2 spasticity AE
CTCAE: E12822
a spasticity AE that has severe increase in muscle tone and increase in resistance through range of motion
YH, MW
Grade 3 spasticity AE
CTCAE: E12823
a spasticity AE that has life-threatening; unable to move active or passive range of motion
YH, MW
Grade 4 spasticity AE
CTCAE: E12824
a treatment related secondary malignancy AE that has non life-threatening secondary malignancy
YH, MW
Grade 3 treatment related secondary malignancy AE
CTCAE: E12562
a treatment related secondary malignancy AE that has acute life-threatening secondary malignancy; blast crisis in leukemia
YH, MW
Grade 4 treatment related secondary malignancy AE
CTCAE: E12563
an abdominal soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
YH, MW
Grade 2 abdominal soft tissue necrosis AE
CTCAE: E12370
an abdominal soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g. tissue reconstruction, flap or grafting)
YH, MW
Grade 3 abdominal soft tissue necrosis AE
CTCAE: E12371
a fibrosis deep connective tissue AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)
YH, MW
Grade 1 fibrosis deep connective tissue AE
CTCAE: E12409
a fibrosis deep connective tissue AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL
YH, MW
Grade 2 fibrosis deep connective tissue AE
CTCAE: E12410
a fibrosis deep connective tissue AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g. mouth, anus); limiting self care ADL
YH, MW
Grade 3 fibrosis deep connective tissue AE
CTCAE: E12411
a fibrosis deep connective tissue AE that has generalized; associated with signs or symptoms of impaired breathing or feeding
YH, MW
Grade 4 fibrosis deep connective tissue AE
CTCAE: E12412
a growth suppression AE that has reduction in growth velocity by 10 - 29% ideally measured over the period of a year
YH, MW
Grade 1 growth suppression AE
CTCAE: E12423
a growth suppression AE that has reduction in growth velocity by 30 - 49% ideally measured over the period of a year or 0 - 49% reduction in growth from the baseline growth curve
YH, MW
Grade 2 growth suppression AE
CTCAE: E12424
a growth suppression AE that has reduction in growth velocity of >=50% ideally measured over the period of a year
YH, MW
Grade 3 growth suppression AE
CTCAE: E12425
a head soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
YH, MW
Grade 2 head soft tissue necrosis AE
CTCAE: E12427
a head soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
YH, MW
Grade 3 head soft tissue necrosis AE
CTCAE: E12428
a joint range of motion decreased cervical spine AE that has mild restriction of rotation or flexion between 60 - 70 degrees
YH, MW
Grade 1 joint range of motion decreased cervical spine AE
CTCAE: E12440
a joint range of motion decreased cervical spine AE that has rotation <60 degrees to right or left; <60 degrees of flexion
YH, MW
Grade 2 joint range of motion decreased cervical spine AE
CTCAE: E12441
a joint range of motion decreased cervical spine AE that has ankylosed/fused over multiple segments with no C-spine rotation
YH, MW
Grade 3 joint range of motion decreased cervical spine AE
CTCAE: E12442
a joint range of motion decreased lumbar spine AE that has stiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity
YH, MW
Grade 1 joint range of motion decreased lumbar spine AE
CTCAE: E12444
a joint range of motion decreased lumbar spine AE that has pain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor
YH, MW
Grade 2 joint range of motion decreased lumbar spine AE
CTCAE: E12445
a joint range of motion decreased lumbar spine AE that requires <50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object)
YH, MW
Grade 3 joint range of motion decreased lumbar spine AE
CTCAE: E12446
a neck soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
YH, MW
Grade 2 neck soft tissue necrosis AE
CTCAE: E12498
a neck soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
YH, MW
Grade 3 neck soft tissue necrosis AE
CTCAE: E12499
a pelvic soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
YH, MW
Grade 2 pelvic soft tissue necrosis AE
CTCAE: E12517
a pelvic soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
YH, MW
Grade 3 pelvic soft tissue necrosis AE
CTCAE: E12518
a scoliosis AE that requires <20 degrees; clinically undetectable
YH, MW
Grade 1 scoliosis AE
CTCAE: E12522
a scoliosis AE that requires >20 - 45 degrees; visible by forward flexion; limiting instrumental ADL
YH, MW
Grade 2 scoliosis AE
CTCAE: E12523
a scoliosis AE that requires >45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self care ADL; disabling
YH, MW
Grade 3 scoliosis AE
CTCAE: E12524
a soft tissue necrosis lower limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
YH, MW
Grade 2 soft tissue necrosis lower limb AE
CTCAE: E12526
a soft tissue necrosis lower limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
YH, MW
Grade 3 soft tissue necrosis lower limb AE
CTCAE: E12527
a soft tissue necrosis upper limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications)
YH, MW
Grade 2 soft tissue necrosis upper limb AE
CTCAE: E12531
a soft tissue necrosis upper limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting)
YH, MW
Grade 3 soft tissue necrosis upper limb AE
CTCAE: E12532
a Superficial soft tissue fibrosis AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)
YH, MW
Grade 1 superficial soft tissue fibrosis AE
CTCAE: E12536
a Superficial soft tissue fibrosis AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL
YH, MW
Grade 2 superficial soft tissue fibrosis AE
CTCAE: E12537
a Superficial soft tissue fibrosis AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL
YH, MW
Grade 3 superficial soft tissue fibrosis AE
CTCAE: E12538
a superficial soft tissue fibrosis AE that has generalized; associated with signs or symptoms of impaired breathing or feeding
YH, MW
Grade 4 superficial soft tissue fibrosis AE
CTCAE: E12539
a trismus AE that has decreased ROM (range of motion) without impaired eating
YH, MW
Grade 1 trismus AE
CTCAE: E12542
a trismus AE that has decreased ROM requiring small bites, soft foods or purees
YH, MW
Grade 2 trismus AE
CTCAE: E12543
a trismus AE that has decreased ROM with inability to adequately aliment or hydrate orally
YH, MW
Grade 3 trismus AE
CTCAE: E12544
An unequal limb length AE that has mild length discrepancy <2 cm
YH, MW
Grade 1 unequal limb length AE
CTCAE: E12546
An unequal limb length AE that has moderate length discrepancy 2 - 5 cm; shoe lift indicated; limiting instrumental ADL
YH, MW
Grade 2 unequal limb length AE
CTCAE: E12547
An unequal limb length AE that has severe length discrepancy >5 cm; limiting self care ADL; disabling; operative intervention indicated
YH, MW
Grade 3 unequal limb length AE
CTCAE: E12548
a alkalosis AE that requires pH >normal, but <=7.5
YH, MW
Grade 1 alkalosis AE
CTCAE: E12248
a alkalosis AE that requires pH >7.5
YH, MW
Grade 3 alkalosis AE
CTCAE: E12249
a glucose intolerance AE that has symptomatic; dietary modification or oral agent indicated
YH, MW
Grade 2 glucose intolerance AE
CTCAE: E12266
a glucose intolerance AE that has severe symptoms; insulin indicated
YH, MW
Grade 3 glucose intolerance AE
CTCAE: E12267
a hypermagnesemia AE that requires >ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L
YH, MW
Grade 1 hypermagnesemia AE
CTCAE: E12289
a hypermagnesemia AE that requires >3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L
YH, MW
Grade 3 hypermagnesemia AE
CTCAE: E12290
a hypermagnesemia AE that requires >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences
YH, MW
Grade 4 hypermagnesemia AE
CTCAE: E12291
a hypernatremia AE that requires >ULN - 150 mmol/L
YH, MW
Grade 1 hypernatremia AE
CTCAE: E12294
a hypernatremia AE that requires >150 - 155 mmol/L
YH, MW
Grade 2 hypernatremia AE
CTCAE: E12295
a hypernatremia AE that requires >155 - 160 mmol/L; hospitalization indicated
YH, MW
Grade 3 hypernatremia AE
CTCAE: E12296
a hypernatremia AE that requires >160 mmol/L; life-threatening consequences
YH, MW
Grade 4 hypernatremia AE
CTCAE: E12297
a hypokalemia AE that requires <LLN - 3.0 mmol/L
YH, MW
Grade 1 hypokalemia AE
CTCAE: E12328
a hypokalemia AE that requires <LLN - 3.0 mmol/L; symptomatic; intervention indicated
YH, MW
Grade 2 hypokalemia AE
CTCAE: E12329
a hypokalemia AE that requires <3.0 - 2.5 mmol/L; hospitalization indicated
YH, MW
Grade 3 hypokalemia AE
CTCAE: E12330
a hypokalemia AE that requires <2.5 mmol/L; life-threatening consequences
YH, MW
Grade 4 hypokalemia AE
CTCAE: E12331
a hyponatremia AE that requires <LLN - 130 mmol/L
YH, MW
Grade 1 hyponatremia AE
CTCAE: E12340
a hyponatremia AE that requires <130 - 120 mmol/L
YH, MW
Grade 3 hyponatremia AE
CTCAE: E12341
a hyponatremia AE that requires <120 mmol/L; life-threatening consequences
YH, MW
Grade 4 hyponatremia AE
CTCAE: E12342
an obesity AE that requires BMI 25 - 29.9 kg/m2
YH, MW
Grade 2 obesity AE
CTCAE: E12362
an obesity AE that requires BMI 30 - 39.9 kg/m2
YH, MW
Grade 3 obesity AE
CTCAE: E12363
an obesity AE that requires BMI >=40 kg/m2
YH, MW
Grade 4 obesity AE
CTCAE: E12364
a flushing AE that has symptomatic, associated with hypotension and/or tachycardia; limiting self care ADL
YH, MW
Grade 3 flushing AE
CTCAE: E13774
a hematoma AE that requires minimally invasive evacuation or aspiration
YH, MW
Grade 2 hematoma AE
CTCAE: E13777
a hematoma AE that requires transfusion, radiologic, endoscopic, or elective operative intervention
YH, MW
Grade 3 hematoma AE
CTCAE: E13778
an hypertension AE that has prehypertension (systolic BP 120 - 139 mm Hg or diastolic BP 80 - 89 mm Hg)
YH, MW
Grade 1 hypertension AE
CTCAE: E13786
an hypertension AE that for Adult: has stage 1 hypertension (systolic BP 140 - 159 mm Hg or diastolic BP 90 - 99 mm Hg); medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated; for Pediatric: recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated.
YH, MW
Grade 2 hypertension AE
CTCAE: E13787
an hypertension AE that for Adult has Stage 2 hypertension (systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; for Pediatric: Same as adult.
YH, MW
Grade 3 hypertension AE
CTCAE: E13788
an hypertension AE that for Adult has life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated; for Pediatric: Same as adult
YH, MW
Grade 4 hypertension AE
CTCAE: E13789
a peripheral ischaemia AE that has brief (<24 hrs) episode of ischemia managed non-surgically and without permanent deficit
YH, MW
Grade 2 peripheral ischemia AE
CTCAE: E13811
a peripheral ischaemia AE that has a recurring or prolonged (>=24 hrs) and/or invasive intervention indicated
YH, MW
Grade 3 peripheral ischemia AE
CTCAE: E13812
a vasculitis AE that shows severe symptoms, medical intervention indicated (e.g., steroids)
YH, MW
Grade 3 vasculitis AE
CTCAE: E13840
a vasculitis AE that shows threatening; evidence of peripheral or visceral ischemia; urgent intervention indicated
YH, MW
Grade 4 vasculitis AE
CTCAE: E13841
an alopecia AE that has hair loss of <50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage
YH, MW
Grade 1 alopecia AE
CTCAE: E13612
an alopecia AE that has hair loss of >=50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact
YH, MW
Grade 2 alopecia AE
CTCAE: E13613
a dry skin AE that is coverying <10% BSA and no associated erythema or pruritus
YH, MW
Grade 1 dry skin AE
CTCAE: E13624
a dry skin AE that is coverying 10 - 30% BSA and associated with erythema or pruritus; limiting instrumental ADL
YH, MW
Grade 2 dry skin AE
CTCAE: E13625
a dry skin AE that is coverying >30% BSA and associated with pruritus; limiting self care ADL
YH, MW
Grade 3 dry skin AE
CTCAE: E13626
an erythema multiforme AE that has target lesions covering <10% BSA and not associated with skin tenderness
YH, MW
Grade 1 erythema multiforme AE
CTCAE: E13628
an erythema multiforme AE that has target lesions covering 10 - 30% BSA and associated with skin tenderness
YH, MW
Grade 2 erythema multiforme AE
CTCAE: E13629
an erythema multiforme AE that has target lesions covering >30% BSA and associated with oral or genital erosions
YH, MW
Grade 3 erythema multiforme AE
CTCAE: E13630
an erythema multiforme AE that has target lesions covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated
YH, MW
Grade 4 erythema multiforme AE
CTCAE: E13631
a hyperhidros AE that shows limited to one site (palms, soles, or axillae); self care interventions
YH, MW
Grade 1 hyperhidrosis AE
CTCAE: E13646
a hyperhidros AE that has Involving >1 site; patient seeks medical intervention; associated with psychosocial impact
YH, MW
Grade 2 hyperhidrosis AE
CTCAE: E13647
a hyperhidros AE that has Generalized involving sites other than palms, soles, or axillae; associated with electrolyte/hemodynamic imbalance
YH, MW
Grade 3 hyperhidrosis AE
CTCAE: E13648
a palmar-plantar erythrodysesthesia syndrome AE that has minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain
YH, MW
Grade 1 palmar-plantar erythrodysesthesia syndrome AE
CTCAE: E13673
a palmar-plantar erythrodysesthesia syndrome AE that has skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL
YH, MW
Grade 2 palmar-plantar erythrodysesthesia syndrome AE
CTCAE: E13674
a palmar-plantar erythrodysesthesia syndrome AE that has severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care ADL
YH, MW
Grade 3 palmar-plantar erythrodysesthesia syndrome AE
CTCAE: E13675
a periorbital edema AE that has soft or non-pitting
YH, MW
Grade 1 periorbital edema AE
CTCAE: E13677
a periorbital edema AE that has indurated or pitting edema; topical intervention indicated
YH, MW
Grade 2 periorbital edema AE
CTCAE: E13678
a periorbital edema AE that has edema associated with visual disturbance; increased intraocular pressure, glaucoma or retinal hemorrhage; optic neuritis; diuretics indicated; operative intervention indicated
YH, MW
Grade 3 periorbital edema AE
CTCAE: E13679
a photosensitivity reaction AE that has painless erythema and erythema covering <10% BSA
YH, MW
Grade 1 photosensitivity AE
CTCAE: E13681
a photosensitivity reaction AE that has tender erythema covering 10 - 30% BSA
YH, MW
Grade 2 photosensitivity AE
CTCAE: E13682
a photosensitivity reaction AE that has erythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs)
YH, MW
Grade 3 photosensitivity AE
CTCAE: E13683
a pruritus AE that has mild or localized; topical intervention indicated
YH, MW
Grade 1 pruritus AE
CTCAE: E13687
a pruritus AE that has intense or widespread; intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL
YH, MW
Grade 2 pruritus AE
CTCAE: E13688
a pruritus AE that has intense or widespread; constant; limiting self care ADL or sleep; oral corticosteroid or immunosuppressive therapy indicated
YH, MW
Grade 3 pruritus AE
CTCAE: E13689
a purpura AE that has combined area of lesions covering <10% BSA
YH, MW
Grade 1 purpura AE
CTCAE: E13691
a purpura AE that has combined area of lesions covering 10 - 30% BSA; bleeding with trauma
YH, MW
Grade 2 purpura AE
CTCAE: E13692
a purpura AE that has combined area of lesions covering >30% BSA; spontaneous bleeding
YH, MW
Grade 3 purpura AE
CTCAE: E13693
a skin atrophy AE that has covering <10% BSA; associated with telangiectasias or changes in skin color
YH, MW
Grade 1 skin atrophy AE
CTCAE: E13715
a skin atrophy AE that has covering 10 - 30% BSA; associated with striae or adnexal structure loss
YH, MW
Grade 2 skin atrophy AE
CTCAE: E13716
a skin atrophy AE that has covering >30% BSA; associated with ulceration
YH, MW
Grade 3 skin atrophy AE
CTCAE: E13717
a skin hyperpigmentation AE that has hyperpigmentation covering <10% BSA; no psychosocial impact
YH, MW
Grade 1 skin hyperpigmentation AE
CTCAE: E13719
a skin hyperpigmentation AE that has hyperpigmentation covering >10% BSA; associated psychosocial impact
YH, MW
Grade 2 skin hyperpigmentation AE
CTCAE: E13720
a skin hypopigmentation AE that has hypopigmentation or depigmentation covering <10% BSA; no psychosocial impact
YH, MW
Grade 1 skin hypopigmentation AE
CTCAE: E13722
a skin hypopigmentation AE that has hypopigmentation or depigmentation covering >10% BSA; associated psychosocial impact
YH, MW
Grade 2 skin hypopigmentation AE
CTCAE: E13723
a stevens-johnson syndrome AE that has skin sloughing covering <10% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment)
YH, MW
Grade 3 stevens-Johnson syndrome AE
CTCAE: E13737
a stevens-johnson syndrome AE that has skin sloughing covering 10 - 30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment)
YH, MW
Grade 4 stevens-Johnson syndrome AE
CTCAE: E13738
a telangiectasia AE that has telangiectasias covering <10% BSA
YH, MW
Grade 1 telangiectasia AE
CTCAE: E13741
a telangiectasia AE that has telangiectasias covering >10% BSA; associated with psychosocial impact
YH, MW
Grade 2 telangiectasia AE
CTCAE: E13742
a toxic epidermal necrolysis AE that has skin sloughing covering >=30% BSA with associated symptoms (e.g., erythema, purpura, or epidermal detachment)
YH, MW
Grade 4 toxic epidermal necrolysis AE
CTCAE: E13744
an urticaria AE that has urticarial lesions covering <10% BSA; topical intervention indicated
YH, MW
Grade 1 urticaria AE
CTCAE: E13747
an urticaria AE that has urticarial lesions covering 10 - 30% BSA; oral intervention indicated
YH, MW
Grade 2 urticaria AE
CTCAE: E13748
an urticaria AE that has urticariallesions covering >30% BSA; IV intervention indicated
YH, MW
Grade 3 urticaria AE
CTCAE: E13749
an aspiration AE that has altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen)
YH, MW
Grade 2 aspiration AE
CTCAE: E13312
an aspiration AE that has dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally
YH, MW
Grade 3 aspiration AE
CTCAE: E13313
an atelectasis AE that has symptomatic (e.g., dyspnea, cough); medical intervention indicated (e.g., chest physiotherapy, suctioning); bronchoscopic suctioning
YH, MW
Grade 2 atelectasis AE
CTCAE: E13318
an atelectasis AE that has oxygen indicated; hospitalization or elective operative intervention indicated (e.g., stent, laser)
YH, MW
Grade 3 atelectasis AE
CTCAE: E13319
a chylothorax AE that has symptomatic; thoracentesis or tube drainage indicated
YH, MW
Grade 2 chylothorax AE
CTCAE: E13360
a chylothorax AE that has severe symptoms; elective operative intervention indicated
YH, MW
Grade 3 chylothorax AE
CTCAE: E13361
an epistaxis AE that has moderate symptoms; medical intervention indicated (e.g., nasal packing, cauterization; topical vasoconstrictors)
YH, MW
Grade 2 epistaxis AE
CTCAE: E13376
a Hiccups AE that has interfering with sleep; limiting self care ADL
YH, MW
Grade 3 hiccups AE
CTCAE: E13383
a hoarseness AE that has mild or intermittent voice change; fully understandable; self-resolves
YH, MW
Grade 1 hoarseness AE
CTCAE: E13385
a hoarseness AE that has Moderate or persistent voice changes; may require occasional repetition but understandable on telephone; medical evaluation indicated
YH, MW
Grade 2 hoarseness AE
CTCAE: E13386
a hoarseness AE that has severe voice changes including predominantly whispered speech
YH, MW
Grade 3 hoarseness AE
CTCAE: E13387
a hypoxia AE that has decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen
YH, MW
Grade 2 hypoxia AE
CTCAE: E13389
a hypoxia AE that has decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg)
YH, MW
Grade 3 hypoxia AE
CTCAE: E13390
a hypoxia AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
YH, MW
Grade 4 hypoxia AE
CTCAE: E13391
a laryngeal edema AE that has stridor; respiratory distress; hospitalization indicated
YH, MW
Grade 3 laryngeal edema AE
CTCAE: E13396
a laryngeal edema AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
YH, MW
Grade 4 laryngeal edema AE
CTCAE: E13397
a pleural effusion AE that has symptomatic; intervention indicated (e.g., diuretics or limited therapeutic thoracentesis)
YH, MW
Grade 2 pleural effusion AE
CTCAE: E13488
a pleural effusion AE that has symptomatic with respiratory distress and hypoxia; surgical intervention including chest tube or pleurodesis indicated
YH, MW
Grade 3 pleural effusion AE
CTCAE: E13489
a pleural hemorrhage AE that has asymptomatic; mild hemorrhage confirmed by thoracentesis
YH, MW
Grade 1 pleural hemorrhage AE
CTCAE: E13493
a pleural hemorrhage AE that has symptomatic or associated with pneumothorax; chest tube drainage indicated
YH, MW
Grade 2 pleural hemorrhage AE
CTCAE: E13494
a pleural hemorrhage AE that has >1000 ml of blood evacuated; persistent bleeding (150-200 ml/hr for 2 - 4 hr); persistent transfusion indicated; elective operative intervention indicated
YH, MW
Grade 3 pleural hemorrhage AE
CTCAE: E13495
a pneumonitis AE that has severe symptoms; limiting self care ADL; oxygen indicated
YH, MW
Grade 3 pneumonitis AE
CTCAE: E13505
a pneumonitis AE that has life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
YH, MW
Grade 4 pneumonitis AE
CTCAE: E13506
a pneumothorax AE that has symptomatic; intervention indicated (e.g., tube placement without sclerosis)
YH, MW
Grade 2 pneumothorax AE
CTCAE: E13510
a pneumothorax AE that has sclerosis and/or operative intervention indicated; hospitalization indicated
YH, MW
Grade 3 pneumothorax AE
CTCAE: E13511
a productive cough AE that has occasional/minimal production of sputum with cough
YH, MW
Grade 1 productive cough AE
CTCAE: E13518
a productive cough AE that has moderate sputum production; limiting instrumental ADL
YH, MW
Grade 2 productive cough AE
CTCAE: E13519
a productive cough AE that has persistent or copious production of sputum; limiting self care ADL
YH, MW
Grade 3 productive cough AE
CTCAE: E13520
a pulmonary edema AE that has radiologic findings only; minimal dyspnea on exertion
YH, MW
Grade 1 pulmonary edema AE
CTCAE: E13522
a pulmonary edema AE that has moderate dyspnea on exertion; medical intervention indicated; limiting instrumental ADL
YH, MW
Grade 2 pulmonary edema AE
CTCAE: E13523
a pulmonary edema AE that has severe dyspnea or dyspnea at rest; oxygen indicated; limiting self care ADL
YH, MW
Grade 3 pulmonary edema AE
CTCAE: E13524
a pulmonary edema AE that has life-threatening respiratory compromise; urgent intervention or intubation with ventilatory support indicated
YH, MW
Grade 4 pulmonary edema AE
CTCAE: E13525
a pulmonary fibrosis AE that has mild hypoxemia; radiologic pulmonary fibrosis <25% of lung volume
YH, MW
Grade 1 pulmonary fibrosis AE
CTCAE: E13528
a pulmonary fibrosis AE that has moderate hypoxemia; evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25 - 50%
YH, MW
Grade 2 pulmonary fibrosis AE
CTCAE: E13529
a pulmonary fibrosis AE that has severe hypoxemia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50 - 75%
YH, MW
Grade 3 pulmonary fibrosis AE
CTCAE: E13530
a pulmonary fibrosis AE that has life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing
YH, MW
Grade 4 pulmonary fibrosis AE
CTCAE: E13531
a pulmonary hypertension AE that has minimal dyspnea; findings on physical exam or other evaluation
YH, MW
Grade 1 pulmonary hypertension AE
CTCAE: E13540
a pulmonary hypertension AE that has moderate dyspnea, cough; requiring evaluation by cardiac catheterization and medical intervention
YH, MW
Grade 2 pulmonary hypertension AE
CTCAE: E13541
a pulmonary hypertension AE that has severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated
YH, MW
Grade 3 pulmonary hypertension AE
CTCAE: E13542
a pulmonary hypertension AE that has life-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation)
YH, MW
Grade 4 pulmonary hypertension AE
CTCAE: E13543
a sinus disorder AE that has asymptomatic mucosal crusting; blood-tinged secretions
YH, MW
Grade 1 sinus disorder AE
CTCAE: E13561
a sinus disorder AE that has symptomatic stenosis or edema/narrowing interfering with airflow; limiting instrumental ADL
YH, MW
Grade 2 sinus disorder AE
CTCAE: E13562
a sinus disorder AE that has stenosis with significant nasal obstruction; limiting self care ADL
YH, MW
Grade 3 sinus disorder AE
CTCAE: E13563
a sinus disorder AE that has necrosis of soft tissue or bone; urgent operative intervention indicated
YH, MW
Grade 4 sinus disorder AE
CTCAE: E13564
a sore throat AE that has Severe pain; limiting self care ADL; limiting ability to swallow
YH, MW
Grade 3 sore throat AE
CTCAE: E13578
a stridor AE that has respiratory distress limiting self care ADL; medical intervention indicated
YH, MW
Grade 3 stridor AE
CTCAE: E13580
a stridor AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
YH, MW
Grade 4 stridor AE
CTCAE: E13581
a voice alteration AE that has mild or intermittent change from normal voice
YH, MW
Grade 1 voice alteration AE
CTCAE: E13602
a voice alteration AE that has moderate or persistent change from normal voice; still understandable
YH, MW
Grade 2 voice alteration AE
CTCAE: E13603
a voice alteration AE that has severe voice changes including predominantly whispered speech; may require frequent repetition or face-to-face contact for understandability; may require assistive technology
YH, MW
Grade 3 voice alteration AE
CTCAE: E13604
a wheezing AE that has detectable airway noise with minimal symptoms
YH, MW
Grade 1 wheezing AE
CTCAE: E13606
a wheezing AE that has severe respiratory symptoms limiting self care ADL; oxygen therapy or hospitalization indicated
YH, MW
Grade 3 wheezing AE
CTCAE: E13608
a menorrhagia AE that has moderate symptoms; medical intervention indicated (e.g., hormones)
YH, MW
Grade 2 menorrhagia AE
CTCAE: E13134
a menorrhagia AE that has severe; transfusion indicated; surgical intervention indicated (e.g., hysterectomy)
YH, MW
Grade 3 menorrhagia AE
CTCAE: E13135
an acute kidney injury AE that has creatinine level increase of >0.3 mg/dL; creatinine 1.5 - 2.0 x above baseline
YH, MW
Grade 1 acute kidney injury AE
CTCAE: E12974
an acute kidney injury AE that has creatinine 2 - 3 x above baseline
YH, MW
Grade 2 acute kidney injury AE
CTCAE: E12975
an acute kidney injury AE that has creatinine >3 x baseline or >4.0 mg/dL; hospitalization indicated
YH, MW
Grade 3 acute kidney injury AE
CTCAE: E12976
a hematuria AE that has symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL
YH, MW
Grade 2 hematuria AE
CTCAE: E13002
a hematuria AE that has gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated; limiting self care ADL
YH, MW
Grade 3 hematuria AE
CTCAE: E13003
an urinary incontinence AE that has occasional (e.g., with coughing, sneezing, etc.), pads not indicated
YH, MW
Grade 1 urinary incontinence AE
CTCAE: E13043
an urinary incontinence AE that has spontaneous; pads indicated; limiting instrumental ADL
YH, MW
Grade 2 urinary incontinence AE
CTCAE: E13044
an urinary incontinence AE that has Intervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL
YH, MW
Grade 3 urinary incontinence AE
CTCAE: E13045
an urinary retention AE that has urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual
YH, MW
Grade 1 urinary retention AE
CTCAE: E13047
an urinary retention AE that has placement of urinary, suprapubic or intermittent catheter placement indicated; medication indicated
YH, MW
Grade 2 urinary retention AE
CTCAE: E13048
an urinary retention AE that has elective operative or radiologic intervention indicated; substantial loss of affected kidney function or mass
YH, MW
Grade 3 urinary retention AE
CTCAE: E13049
a suicidal ideation AE that has increased thoughts of death but no wish to kill oneself
YH, MW
Grade 1 suicidal ideation AE
CTCAE: E12965
a suicidal ideation AE that has suicidal ideation with no specific plan or intent
YH, MW
Grade 2 suicidal ideation AE
CTCAE: E12966
a suicidal ideation AE that has specific plan to commit suicide without serious intent to die which may not require hospitalization
YH, MW
Grade 3 suicidal ideation AE
CTCAE: E12967
a suicidal ideation AE that has specific plan to commit suicide with serious intent to die which requires hospitalization
YH, MW
Grade 4 suicidal ideation AE
CTCAE: E12968
a suicide attempt AE that has suicide attempt or gesture without intent to die which may not require hospitalization
YH, MW
Grade 3 suicide attempt AE
CTCAE: E12970
a suicide attempt AE that has suicide attempt with intent to die which requires hospitalization
YH, MW
Grade 4 suicide attempt AE
CTCAE: E12971
an aphonia AE that has voicelessness; unable to speak
YH, MW
Grade 3 aphonia AE
CTCAE: E12590
a depressed level of consciousness AE that has decreased level of alertness
YH, MW
Grade 1 depressed level of consciousness AE
CTCAE: E12626
a depressed level of consciousness AE that has Sedation; slow response to stimuli; limiting instrumental ADL
YH, MW
Grade 2 depressed level of consciousness AE
CTCAE: E12627
a depressed level of consciousness AE that is difficult to arouse
YH, MW
Grade 3 depressed level of consciousness AE
CTCAE: E12628
a dysgenusia AE that has altered taste but no change in diet
YH, MW
Grade 1 dysgeusia AE
CTCAE: E12644
a dysgenusia AE that has altered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste
YH, MW
Grade 2 dysgeusia AE
CTCAE: E12645
a leukoencephalopathy AE that has asymptomatic; small focal T2/FLAIR hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (SAS) and/or mild ventriculomegaly
YH, MW
Grade 1 leukoencephalopathy AE
CTCAE: E12713
a leukoencephalopathy AE that has moderate symptoms; focal T2/FLAIR hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in SAS and/or moderate ventriculomegaly
YH, MW
Grade 2 leukoencephalopathy AE
CTCAE: E12714
a leukoencephalopathy AE that has severe symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly
YH, MW
Grade 3 leukoencephalopathy AE
CTCAE: E12715
a leukoencephalopathy AE that has life-threatening consequences; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving most of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly
YH, MW
Grade 4 leukoencephalopathy AE
CTCAE: E12716
a myelitis AE that has asymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign)
YH, MW
Grade 1 myelitis AE
CTCAE: E12733
a myelitis AE that has moderate weakness or sensory loss; limiting instrumental ADL
YH, MW
Grade 2 myelitis AE
CTCAE: E12734
a myelitis AE that has severe weakness or sensory loss; limiting self care ADL
YH, MW
Grade 3 myelitis AE
CTCAE: E12735
a presyncope AE that has present (e.g., near fainting)
YH, MW
Grade 2 presyncope AE
CTCAE: E12779
a seizure AE that has brief partial seizure; no loss of consciousness
YH, MW
Grade 1 seizure AE
CTCAE: E12805
a seizure AE that has brief generalized seizure
YH, MW
Grade 2 seizure AE
CTCAE: E12806
a seizure AE that has multiple seizures despite medical intervention
YH, MW
Grade 3 seizure AE
CTCAE: E12807
a seizure AE that has life-threatening; prolonged repetitive seizures
YH, MW
Grade 4 seizure AE
CTCAE: E12808
a somnolence AE that has mild but more than usual drowsiness or sleepiness
YH, MW
Grade 1 somnolence AE
CTCAE: E12815
a somnolence AE that has moderate sedation; limiting instrumental ADL
YH, MW
Grade 2 somnolence AE
CTCAE: E12816
a somnolence AE that has obtundation or stupor
YH, MW
Grade 3 somnolence AE
CTCAE: E12817
a syncope AE that has fainting; orthostatic collapse
YH, MW
Grade 3 syncope AE
CTCAE: E12833
an arthritis AE that has mild pain with inflammation, erythema, or joint swelling
YH, MW
Grade 1 arthritis AE
CTCAE: E12379
an arthritis AE that has moderate pain associated with signs of inflammation, erythema, or joint swelling; limiting instrumental ADL
YH, MW
Grade 2 arthritis AE
CTCAE: E12380
an arthritis AE that has severe pain associated with signs of inflammation, erythema, or joint swelling; irreversible joint damage; disabling; limiting self care ADL
YH, MW
Grade 3 arthritis AE
CTCAE: E12381
a joint range of motion decreased AE that requires <=25% loss of ROM (range of motion); decreased ROM limiting athletic activity
YH, MW
Grade 1 joint range of motion decreased AE
CTCAE: E12436
a joint range of motion decreased AE that requires >25 - 50% decrease in ROM; limiting instrumental ADL
YH, MW
Grade 2 joint range of motion decreased AE
CTCAE: E12437
a joint range of motion decreased AE that requires >50% decrease in ROM; limiting self care ADL; disabling
YH, MW
Grade 3 joint range of motion decreased AE
CTCAE: E12438
an osteoporosis AE that has radiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); no loss of height or intervention indicated
YH, MW
Grade 1 osteoporosis AE
CTCAE: E12509
an osteoporosis AE that has BMD t-score <-2.5; loss of height <2 cm; anti-osteoporotic therapy indicated; limiting instrumental ADL
YH, MW
Grade 2 osteoporosis AE
CTCAE: E12510
an osteoporosis AE that has loss of height >=2 cm; hospitalization indicated; limiting self care ADL
YH, MW
Grade 3 osteoporosis AE
CTCAE: E12511
an acidosis AE that has pH <normal, but >=7.3
YH, MW
Grade 1 acidosis AE
CTCAE: E12238
an acidosis AE that has pH <7.3
YH, MW
Grade 3 acidosis AE
CTCAE: E12239
an anorexia AE that has loss of appetite without alteration in eating habits
YH, MW
Grade 1 anorexia AE
CTCAE: E12253
an anorexia AE that has oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated
YH, MW
Grade 2 anorexia AE
CTCAE: E12254
an anorexia AE that has associated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); tube feeding or TPN indicated
YH, MW
Grade 3 anorexia AE
CTCAE: E12255
a dehydration AE that has increased oral fluids indicated; dry mucous membranes; diminished skin turgor
YH, MW
Grade 1 dehydration AE
CTCAE: E12259
a dehydration AE that requires IIV fluids indicated <24 hrs
YH, MW
Grade 2 dehydration AE
CTCAE: E12260
a hypercalcemia AE that has corrected serum calcium of >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L; Ionized calcium >ULN - 1.5 mmol/L
YH, MW
Grade 1 hypercalcemia AE
CTCAE: E12271
a hypercalcemia AE that has corrected serum calcium of >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L; Ionized calcium >1.5 - 1.6 mmol/L; symptomatic
YH, MW
Grade 2 hypercalcemia AE
CTCAE: E12272
a hypercalcemia AE that has corrected serum calcium of >12.5 - 13.5 mg/dL; >3.1 - 3.4 mmol/L; Ionized calcium >1.6 - 1.8 mmol/L; hospitalization indicated
YH, MW
Grade 3 hypercalcemia AE
CTCAE: E12273
a hypercalcemia AE that has corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences
YH, MW
Grade 4 hypercalcemia AE
CTCAE: E12274
a hypeglycemia AE that has fasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L
YH, MW
Grade 1 hyperglycemia AE
CTCAE: E12277
a hypeglycemia AE that has fasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L
YH, MW
Grade 2 hyperglycemia AE
CTCAE: E12278
a hypeglycemia AE that has >250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated
YH, MW
Grade 3 hyperglycemia AE
CTCAE: E12279
a hypeglycemia AE that has >500 mg/dL; >27.8 mmol/L; life-threatening consequences
YH, MW
Grade 4 hyperglycemia AE
CTCAE: E12280
a hyperkalemia AE that requires >ULN - 5.5 mmol/L
YH, MW
Grade 1 hyperkalemia AE
CTCAE: E12283
a hyperkalemia AE that requires >5.5 - 6.0 mmol/L
YH, MW
Grade 2 hyperkalemia AE
CTCAE: E12284
a hyperkalemia AE that requires >6.0 - 7.0 mmol/L; hospitalization indicated
YH, MW
Grade 3 hyperkalemia AE
CTCAE: E12285
a hyperkalemia AE that requires >7.0 mmol/L; life-threatening consequences
YH, MW
Grade 4 hyperkalemia AE
CTCAE: E12286
a hypertriglyceridemia AE that requires 150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42 mmol/L
YH, MW
Grade 1 hypertriglyceridemia AE
CTCAE: E12300
a hypertriglyceridemia AE that requires >300 mg/dL - 500 mg/dL; >3.42 mmol/L - 5.7 mmol/L
YH, MW
Grade 2 hypertriglyceridemia AE
CTCAE: E12301
a hypertriglyceridemia AE that requires >500 mg/dL - 1000 mg/dL; >5.7 mmol/L - 11.4 mmol/L
YH, MW
Grade 3 hypertriglyceridemia AE
CTCAE: E12302
a hypertriglyceridemia AE that requires >1000 mg/dL; >11.4 mmol/L; life-threatening consequences
YH, MW
Grade 4 hypertriglyceridemia AE
CTCAE: E12303
a hyperuricemia AE that requires >ULN - 10 mg/dL (0.59 mmol/L) without physiologic consequences
YH, MW
Grade 1 hyperuricemia AE
CTCAE: E12306
a hyperuricemia AE that requires >ULN - 10 mg/dL (0.59 mmol/L) with physiologic consequences
YH, MW
Grade 3 hyperuricemia AE
CTCAE: E12307
a hyperuricemia AE that requires >10 mg/dL; >0.59 mmol/L; life-threatening consequences
YH, MW
Grade 4 hyperuricemia AE
CTCAE: E12308
a hypoalbuminemia AE that requires NCI<LLN - 3 g/dL; <LLN - 30 g/L
YH, MW
Grade 1 hypoalbuminemia AE
CTCAE: E12311
a hypoalbuminemia AE that requires NCI<3 - 2 g/dL; <30 - 20 g/L
YH, MW
Grade 2 hypoalbuminemia AE
CTCAE: E12312
a hypoalbuminemia AE that requires NCI<2 g/dL; <20 g/L
YH, MW
Grade 3 hypoalbuminemia AE
CTCAE: E12313
a hypocalcemia AE that requires corrected serum calcium of <LLN - 8.0 mg/dL; <LLN - 2.0 mmol/L; Ionized calcium <LLN - 1.0 mmol/L
YH, MW
Grade 1 hypocalcemia AE
CTCAE: E12317
a hypocalcemia AE that requires corrected serum calcium of <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L; Ionized calcium <1.0 - 0.9 mmol/L; symptomatic
YH, MW
Grade 2 hypocalcemia AE
CTCAE: E12318
a hypocalcemia AE that requires corrected serum calcium of <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L; Ionized calcium <0.9 - 0.8 mmol/L; hospitalization indicated
YH, MW
Grade 3 hypocalcemia AE
CTCAE: E12319
a hypocalcemia AE that requires corrected serum calcium of <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences
YH, MW
Grade 4 hypocalcemia AE
CTCAE: E12320
a hypoglycernia AE that requires <LLN - 55 mg/dL; <LLN - 3.0 mmol/L
YH, MW
Grade 1 hypoglycemia AE
CTCAE: E12323
a hypoglycernia AE that requires <55 - 40 mg/dL; <3.0 - 2.2 mmol/L
YH, MW
Grade 2 hypoglycemia AE
CTCAE: E13874
a hypoglycernia AE that requires <40 - 30 mg/dL; <2.2 - 1.7 mmol/L
YH, MW
Grade 3 hypoglycemia AE
CTCAE: E12324
a hypoglycernia AE that requires <30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures
YH, MW
Grade 4 hypoglycemia AE
CTCAE: E12325
a hypomagnesemia AE that requires <LLN - 1.2 mg/dL; <LLN - 0.5 mmol/L
YH, MW
Grade 1 hypomagnesemia AE
CTCAE: E12334
a hypomagnesemia AE that requires <1.2 - 0.9 mg/dL; <0.5 - 0.4 mmol/L
YH, MW
Grade 2 hypomagnesemia AE
CTCAE: E12335
a hypomagnesemia AE that requires <0.9 - 0.7 mg/dL; <0.4 - 0.3 mmol/L
YH, MW
Grade 3 hypomagnesemia AE
CTCAE: E12336
a hypomagnesemia AE that requires <0.7 mg/dL; <0.3 mmol/L; life-threatening consequences
YH, MW
Grade 4 hypomagnesemia AE
CTCAE: E12337
a hypophosphatemia AE that requires <LLN - 2.5 mg/dL; <LLN - 0.8 mmol/L
YH, MW
Grade 1 hypophosphatemia AE
CTCAE: E12345
a hypophosphatemia AE that requires <2.5 - 2.0 mg/dL; <0.8 - 0.6 mmol/L
YH, MW
Grade 2 hypophosphatemia AE
CTCAE: E12346
a hypophosphatemia AE that requires <2.0 - 1.0 mg/dL; <0.6 - 0.3 mmol/L
YH, MW
Grade 3 hypophosphatemia AE
CTCAE: E12347
a hypophosphatemia AE that requires <1.0 mg/dL; <0.3 mmol/L; life-threatening consequences
YH, MW
Grade 4 hypophosphatemia AE
CTCAE: E12348
YH, JX
a behavioral quality where the behavior in an organism is abnormal.
WEB: https://en.wikipedia.org/wiki/Abnormality_(behavior)
behavior abnormal quality
a cough AE that shows an increased rate of coughing
YH, JX
WEB: http://medical-dictionary.thefreedictionary.com/cough
10011228
cough increased AE
a viral infection AE that is caused by a herpes virus. Note that there are 8 herpesvirus types.
YH, JX
WEB: https://en.wikipedia.org/wiki/Herpesviridae
10019972
herpes viral infection AE
a herpez zoster AE that occurs in children.
YH, JX
WEB: https://en.wikipedia.org/wiki/Varicella_zoster_virus
chickenpox AE
a nervous system AE that shows abnormal neurologic reflexes, which can be tesetd by the knee jerk reaction.
JX, YH
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423
10038254
abnormal reflex AE
an abnormal reflex AE where the patient has a condition of below normal or absent reflexes (areflexia).
JX, YH
WEB: http://www.medicinenet.com/script/main/art.asp?articlekey=20423
10021089
hyporeflexia AE
an abnormal reflex AE that has an outcome of overactive reflexes, indicative of upper motor neuron disease as well as lessening or loss of control ordinarily exerted by higher brain centers of lower neural pathways.
JX, YH
WEB: https://en.wikipedia.org/wiki/Hyperreflexia
10020745
hyperreflexia AE
HPO: HP_0001347
SIDER: C0151889
a cardiac arrest AE where there is no discernible electrical activity on the ECG monitor.
YH, MW
asystole
WEB: http://www.cardiachealth.org/asystole-and-pulseless-electrical-activity
10003586
Asystole is the absence of electrical activity in the heart, as evidenced by a flat line on an EKG. Cardiac arrest is a more general term for conditions where the heart is not circulating blood. Ventricular fibrillation (V-fib) or pulseless Ventricular tachycardia (V-tach) are examples of EKG rhythms which also will produce cardiac arrest, but are not asystole. Pulseless electrical activity (PEA) is another catch-all where there is an otherwise survivable EKG, but no blood is circulating. This can be caused by trauma to the heart, or tremendous blood loss, among other reasons. See: https://answers.yahoo.com/question/index?qid=20081027100243AAy0yt4
asystole AE
CTCAE: E10077
NCit:C50479
an eye inflammation AE that occurs at the corneal area.
MW, YH
WEB: http://www.mayoclinic.org/diseases-conditions/keratitis/basics/definition/con-20035288
10023332
keratitis AE
CTCAE: E10397
NCIT: C26805
an infection AE where one or two eyes get infected by bacteria, fungi, or viruses.
MW, YH
WEB: https://www.nlm.nih.gov/medlineplus/eyeinfections.html
10015929
eye infection AE
CTCAE: E11391
NCIT: C45372
an inflammation AE that shows inflammation at the location of appendix.
MW, YH
10003011
appendicitis AE
CTCAE: E11292
NCIt: C35145
an electrocardiogram QT prolonged AE that estimates the QT interval at a heart rate of 60 bpm.
MW, YH
WEB: http://lifeinthefastlane.com/ecg-library/basics/qt_interval/
10014383
electrocardiogram QT corrected interval prolonged AE
CTCAE: E12146
NCIt: C71034
UMLS: C0855333
a cross product of coordination abnormal AE and balance disorder AE
YH, QL
coordination and balance disturbance AE
10072984
coordination and balance disorder AE
an anorexia AE that has loss of appetite of greasy food.
QL, YH
WEB: http://www.anxietycare.org.uk/docs/eating.asp
aversion to greasy food AE
a coordination and balance disorder AE that has difficulty in standing
YH, QL
dystasia AE
WEB: http://medical-dictionary.thefreedictionary.com/dysstasia
10050218
dysstasia AE
a skin AE that has an outcome of injury to the skin and underlying tissues from exposure to a large external dose of radiation
MW, YH
WEB: http://www.dermnetnz.org/reactions/radiation-dermatitis.html
10061103
dermatitis radiation AE
CTCAE: E11675
NCIt: C0034561
a gastric disorder AE that shows an rupture in the stomach
QL, YH
stomach rupture
WEB: http://medical-dictionary.thefreedictionary.com/gastrorrhexis
gastrorrhexis AE
an injury AE that refers to break or burst suddenly (esp. of a pipe, a vessel, or a bodily part such as an organ or membrane)
YH. QL
WEB: https://en.wikipedia.org/wiki/Rupture
rupture AE
a radiation skin injury AE that shows skin burn from exposure to a large external dose of radiation
MW, YH
WEB: https://en.wikipedia.org/wiki/Radiation_burn
10063640
radiation burn AE
a troponin AE which indicates increased levels of cardiac troponin I in a biological specimen
MW, YH
10007612
cardiac troponin I increased AE
CTCAE: E12116
NCIt: C78230
a musculoskeletal or connective tissue AE that has greater growth than expected for age.
MW, YH
10018746
growth accelerated AE
CTCAE: E10317
NCIt: C83495
a surgery AE that has the finding of a previously undocumented problem that occurs after a thoracic procedure.
MW, YH
10056745
postoperative thoracic procedure complication AE
CTCAE: E11909
NCIt: C78567
a uterine AE that has a rupture in the uterine wall.
MW, YH
10046810
uterine perforation AE
CTCAE: E12028
NCIt: C50793
a female reproductive system AE that has the finding of rupture of the fallopian tube wall.
MW, YH
10065790
fallopian tube perforation AE
CTCAE: E11697
NCIt: C78294
an endocrine system AE that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency.
MW, YH
10001367
adrenal insufficiency AE
CTCAE: E10298
NCIt: C26691
an endocrine system AE that has signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids.
MW, YH
10011655
cushingoid AE
CTCAE: E10304
NCIt: C37938
an endocrine system AE that has unusually late sexual maturity.
MW, YH
10012205
delayed puberty AE
CTCAE: E10308
NCIt: C62587
an endocrine system AE that has an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood).
MW, YH
10020705
hyperparathyroidism AE
CTCAE: E10319
NCIt: C48259
an endocrine system AE that has a decrease in production of parathyroid hormone by the parathyroid glands.
MW, YH
10021041
hypoparathyroidism AE
CTCAE: E10328
NCIt: C78350
an endocrine system AE that has inappropriate masculinization occurring in a female or prepubertal male.
MW, YH
10047488
virilization AE
CTCAE: E10343
NCIt: C79859
an endocrine system AE that has unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys.
MW, YH
10058084
precocious puberty AE
CTCAE: E10340
NCIt: C79704
a medical intervention site AE that has the finding of tumor-like collection of serum in the tissues.
MW, YH
10040102
seroma AE
CTCAE: E11938
NCIt: C50739
a medical intervention site AE that has a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure.
MW, YH
10042127
stomal ulcer AE
CTCAE: E11965
NCIt: C79766
a medical intervention site AE that has a finding of blood leakage from the intestinal stoma.
MW, YH
10049468
intestinal stoma site bleeding AE
CTCAE: E11764
NCIt: C78371
a medical intervention site AE that has the finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10050457
pancreatic anastomotic leak AE
CTCAE: E11891
NCIt: C78518
a medical intervention site AE that has the finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10050458
biliary anastomotic leak AE
CTCAE: E11654
NCIt: C78183
a medical intervention site AE that has the finding of blockage of the normal flow of the contents of the intestinal stoma.
MW, YH
10059094
intestinal stoma leak AE
CTCAE: E11759
NCIt: C78370
a medical intervention site AE that has the finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body).
MW, YH
10059095
intestinal stoma leak AE
CTCAE: E11753
NCIt: C78369
a medical intervention site AE that has the finding of a previously undocumented problem related to the vascular access site.
MW, YH
10062169
vascular access complication AE
CTCAE: E12046
NCIt: C78709
a medical intervention site AE that has the finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065705
pharyngeal anastomotic leak AE
CTCAE: E11897
NCIt: C78550
a medical intervention site AE that has the finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface.
MW, YH
10065745
prolapse of intestinal stoma AE
CTCAE: E11914
NCIt: C78570
a medical intervention site AE that has the finding of bleeding from the urostomy site.
MW, YH
10065748
urostomy site bleeding AE
CTCAE: E12011
NCIt: C78682
a medical intervention site AE that has the finding of blood leakage from the tracheostomy site.
MW, YH
10065749
tracheostomy site bleeding AE
CTCAE: E11981
NCIt: C78648
a medical intervention site AE that has the finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065788
fallopian tube anastomotic leak AE
CTCAE: E11691
NCIt: C78292
a medical intervention site AE that has the finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065802
bladder anastomotic leak AE
CTCAE: E11660
NCIt: C78206
a medical intervention site AE that has the finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065803
kidney anastomotic leak AE
CTCAE: E11879
NCIt: C78406
a medical intervention site AE that has the finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065814
ureteric anastomotic leak AE
CTCAE: E11987
NCIt: C78662
a medical intervention site AE that has the finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065815
urethral anastomotic leak
CTCAE: E11993
NCIt: C78667
a medical intervention site AE that has the finding of displacement of the urostomay
MW, YH
10065822
prolapse of urostomy AE
CTCAE: E11920
NCIt: C78571
a medical intervention site AE that has the finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065879
gastrointestinal anastomotic leak
CTCAE: E11715
NCIt: C78318
a medical intervention site AE that has the finding of leakage of contents from a urostomy.
MW, YH
10065882
urostomy leak AE
CTCAE: E11999
NCIt: C78679
a medical intervention site AE that has the finding of blockage of the urostomy.
MW, YH
10065883
urostomy obstruction AE
CTCAE: E12005
NCIt: C78680
a medical intervention site AE that has the finding of narrowing of the opening of a urostomy.
MW, YH
10065885
urostomy stenosis AE
CTCAE: E12017
NCIt: C78683
a medical intervention site AE that has the finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065886
uterine anastomotic leak AE
CTCAE: E12022
NCIt: C78684
a medical intervention site AE that has the finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065887
vaginal anastomotic leak AE
CTCAE: E12034
NCIt: C78698
a medical intervention site AE that has the finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065888
vas deferens anastomotic leak AE
CTCAE: E12040
NCIt: C78704
a medical intervention site AE that has the finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine.
MW, YH
10065891
large intestinal anastomotic leak AE
CTCAE: E11885
NCIt: C78408
a medical intervention site AE that has the finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel.
MW, YH
10065892
small intestinal anastomotic leak AE
CTCAE: E11942
NCIt: C78612
a medical intervention site AE that has the finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065893
gastric anastomotic leak AE
CTCAE: E11709
NCIt: C78310
a medical intervention site AE that has the finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065894
rectal anastomotic leak AE
CTCAE: E11932
NCIt: C78583
a medical intervention site AE that has the finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065897
spermatic cord anastomotic leak AE
CTCAE: E11948
NCIt: C78622
a medical intervention site AE that has the finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body).
MW, YH
10065898
stenosis of gastrointestinal stoma AE
CTCAE: E11960
NCIt: C78628
a medical intervention site AE that has the finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures).
MW, YH
10065961
esophageal anastomotic leak AE
CTCAE: E11681
NCIt: C78270
an infection AE that has an infectious process involving the bladder.
MW, YH
10005047
bladder infection AE
CTCAE: E11309
NCIt: C26738
an infection AE that has an infectious process involving the uterine cervix.
MW, YH
10008330
cervicitis infection AE
CTCAE: E11337
NCIt: C78360
an infection AE that has an infectious process involving the brain tissue.
MW, YH
10014594
encephalitis infection AE
CTCAE: E11365
NCIt: C79550
an infection AE that has an infectious process involving the brain and spinal cord tissues.
MW, YH
10014621
encephalomyelitis infection AE
CTCAE: E11369
NCIt: C79551
an infection AE that has an infectious process involving the endocardial layer of the heart.
MW, YH
10014678
endocarditis infective AE
CTCAE: E11373
NCIt: C78265
an infection AE that has an infectious process involving the gums.
MW, YH
10018784
gum infection AE
CTCAE: E11400
NCIt: C78329
an infection AE that has an infectious process involving the skeletal muscles.
MW, YH
10021918
infective myositis AE
CTCAE: E11421
NCIt: C26984
an infection AE that has an infectious process involving a joint.
MW, YH
10023216
joint infection AE
CTCAE: E11426
NCIt: C78402
an infection AE that has an infectious process involving the kidney.
MW, YH
10023424
kidney infection AE
CTCAE: E11431
NCIt: C34965
an infection AE that has an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage.
MW, YH
10033072
otitis externa AE
CTCAE: E11472
NCIt: C3299
an infection AE that has an infectious process involving the salivary gland.
MW, YH
10039413
salivary gland infection AE
CTCAE: E11550
NCIt: C78601
an infection AE that has an infectious process involving the wound.
MW, YH
10048038
wound infection AE
CTCAE: E11635
NCIt: C45234
an infection AE that has an infectious process involving a tooth.
MW, YH
10048762
tooth infection AE
CTCAE: E11594
NCIt: C78639
an infection AE that has an infectious process involving the prostate gland.
MW, YH
10050662
prostate infection AE
CTCAE: E11540
NCIt: C27615
an infection AE that has an infectious process involving the lymph nodes.
MW, YH
10050823
lymph gland infection AE
CTCAE: E11449
NCIt: C26821
an infection AE that has an infectious process involving the pancreas.
MW, YH
10051741
pancreas infection AE
CTCAE: E11487
NCIt: C78517
an infection AE that has an infectious process involving the urethra.
MW, YH
10052298
urethral infection AE
CTCAE: E11609
NCIt: C78671
an infection AE that has an infectious process involving the ovary.
MW, YH
10055005
ovarian infection AE
CTCAE: E11482
NCIt: C78512
an infection AE that has an infectious process involving the abdominal cavity.
MW, YH
10056519
abdominal infection AE
CTCAE: E11282
NCIt: C35669
an infection AE that has an infectious process involving the liver.
MW, YH
10056522
hepatic infection AE
CTCAE: E11406
NCIt: C78339
an infection AE that has an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein.
MW, YH
10056627
phlebitis infective AE
CTCAE: E11530
NCIt: C78558
an infection AE that has an infectious process involving the peritoneum.
MW, YH
10057262
peritoneal infection AE
CTCAE: E11521
NCIt: C78540
an infection AE that has an infectious process involving the mediastinum.
MW, YH
10057483
mediastinal infection AE
CTCAE: E11454
NCIt: C26827
an infection AE that has an infectious process involving the pelvic cavity.
MW, YH
10058674
pelvic infection AE
CTCAE: E11501
NCIt: C3889
an infection AE that has an infectious process involving the esophagus.
MW, YH
10058804
esophageal infection AE
CTCAE: E11386
NCIt: C78277
an infection AE that has an infectious process involving the small and large intestines.
MW, YH
10058838
enterocolitis infectious AE
CTCAE: E11381
NCIt: C80513
an infection AE that has an infectious process involving the nasal mucosal.
MW, YH
10059827
rhinitis infective AE
CTCAE: E11548
NCIt: C78599
an infection AE that has an infectious process involving the bones.
MW, YH
10061017
bone infection AE
CTCAE: E11314
NCIt: C26839
an infection AE that has an infectious process involving the pleura.
MW, YH
10061351
pleural infection AE
CTCAE: E11535
NCIt: C78563
an infection AE that has an infectious process involving the anal area and the rectum.
MW, YH
10061640
anorectal infection AE
CTCAE: E11286
NCIt: C78174
an infection AE that has an infectious process involving the biliary tract.
MW, YH
10061695
biliary tract infection AE
CTCAE: E11305
NCIt: C26718
an infection AE that has an infectious process involving the penis.
MW, YH
10061912
penile infection AE
CTCAE: E11506
NCIt: C78526
an infection AE that has an infectious process involving the spleen.
MW, YH
10062112
splenic infection AE
CTCAE: E11584
NCIt: C78627
an infection AE that has an infectious process involving the scrotum.
MW, YH
10062156
scrotal infection AE
CTCAE: E11555
NCIt: C78606
an infection AE that has an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues.
MW, YH
10062233
uterine infection AE
CTCAE: E11619
NCIt: C26764
an infection AE that has an infectious process involving the gallbladder.
MW, YH
10062632
gallbladder infection AE
CTCAE: E11396
NCIt: C78306
an infection AE that has an infectious process involving a stoma (surgically created opening on the surface of the body).
MW, YH
10064505
stoma site infection AE
CTCAE: E11588
NCIt: C78629
an infection AE that has an infectious process involving an artery.
MW, YH
10065744
arteritis infective AE
CTCAE: E11301
NCIt: C34399
an infection AE that has an infectious process involving the duodenum.
MW, YH
10065752
duodenal infection AE
CTCAE: E11360
NCIt: C78258
an infection AE that has an infectious process involving the lips.
MW, YH
10065755
lip infection AE
CTCAE: E11440
NCIt: C78434
an infection AE that has an infectious process involving the cecum.
MW, YH
10065761
cecal infection AE
CTCAE: E11333
NCIt: C78235
an infection AE that has an infectious process involving a mucosal surface.
MW, YH
10065764
mucosal infection AE
CTCAE: E11462
NCIt: C78454
an infection AE that has an infectious process involving a cranial nerve.
MW, YH
10065765
cranial nerve infection AE
CTCAE: E11352
NCIt: C78248
an infection AE that has an infectious process involving the peripheral nerves.
MW, YH
10065766
peripheral nerve infection AE
CTCAE: E11516
NCIt: C27589
an infection AE that has an infectious process involving the small intestine.
MW, YH
10065771
small intestine infection AE
CTCAE: E11574
NCIt: C78618
an infection AE that has an infectious process involving the vulva.
MW, YH
10065772
vulval infection AE
CTCAE: E11629
NCIt: C78716
a pain AE that has a sensation of marked discomfort in the anal region.
MW, YH
10002167
anal pain AE
CTCAE: E10486
NCIt: C78172
a pain AE that has a sensation of marked discomfort in the gallbladder region.
MW, YH
10017638
gallbladder pain AE
CTCAE: E11204
NCIt: C78304
a pain AE that has a sensation of marked discomfort in the gastrointestinal region.
MW, YH
10017999
gastrointestinal pain AE
CTCAE: E10755
NCIt: C78320
a pain AE that has a sensation of marked discomfort in the liver region.
MW, YH
10019705
hepatic pain AE
CTCAE: E11224
NCIt: C78341
a pain AE that has a sensation of marked discomfort of the lip.
MW, YH
10024561
lip pain AE
CTCAE: E10857
NCIt: C79684
a pain AE that has a sensation of marked discomfort in the rectal region.
MW, YH
10038072
rectal pain AE
CTCAE: E10977
NCIt: C78587
a pain AE that has a sensation of marked discomfort in the stomach.
MW, YH
10042112
stomach pain AE
CTCAE: E11044
NCIt: C78630
a chest pain AE that has discomfort in the chest unrelated to a heart disorder.
MW, YH
10062501
non-cardiac chest pain AE
CTCAE: E11163
NCIt: C78504
a respiratory system AE that has the finding of blockage of the lumen of the trachea.
MW, YH
10044291
tracheal obstruction AE
CTCAE: E11975
NCIt: C78645
a hemorrhage AE that has bleeding from the colon.
MW, YH
10009998
colonic hemorrhage AE
CTCAE: E10533
NCIt: C78240
a hemorrhage AE that has bleeding from the esophagus.
MW, YH
10015384
esophageal hemorrhage AE
CTCAE: E10645
NCIt: C78271
a hemorrhage AE that has bleeding from esophageal varices.
MW, YH
10015453
esophageal varices hemorrhage AE
CTCAE: E10682
NCIt: C78282
a hemorrhage AE that has bleeding from the liver.
MW, YH
10019678
hepatic hemorrhage AE
CTCAE: E11215
NCIt: C78338
a hemorrhage AE that has bleeding from the mouth.
MW, YH
10030980
oral hemorrhage AE
CTCAE: E10898
NCIt: C79699
a hemorrhage AE that has bleeding from the pancreas.
MW, YH
10033626
pancreatic hemorrhage AE
CTCAE: E10920
NCIt: C78521
a hemorrhage AE that has bleeding from the retroperitoneal area.
MW, YH
10038981
retroperitoneal hemorrhage AE
CTCAE: E10998
NCIt: C26944
a hemorrhage AE that has bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).
MW, YH
10051746
lower gastrointestinal hemorrhage AE
CTCAE: E10861
NCIt: C78438
a hemorrhage AE that has bleeding from the duodenum.
MW, YH
10055242
duodenal hemorrhage AE
CTCAE: E10588
NCIt: C78257
a hemorrhage AE that has bleeding from the ileal wall.
MW, YH
10055287
ileal hemorrhage AE
CTCAE: E10783
NCIt: C78353
a hemorrhage AE that has bleeding in the abdominal cavity.
MW, YH
10055291
intra-abdominal hemorrhage AE
CTCAE: E10817
NCIt: C78372
a hemorrhage AE that has bleeding from the jejunal wall.
MW, YH
10055300
jejunal hemorrhage AE
CTCAE: E10828
NCIt: C78397
a hemorrhage AE that has the finding of bleeding occurring after a surgical procedure.
MW, YH
10055322
postoperative hemorrhage AE
CTCAE: E11903
NCIt: C34938
a hemorrhage AE that has the finding of bleeding from the trachea.
MW, YH
10062548
tracheal hemorrhage AE
CTCAE: E11969
NCIt: C78642
a hemorrhage AE that has bleeding from the cecum.
MW, YH
10065747
cecal hemorrhage AE
CTCAE: E10511
NCIt: C78234
an anus AE that has a narrowing of the lumen of the anal canal.
MW, YH
10002176
anal stenosis AE
CTCAE: E10490
NCIt: C78173
a digestive system AE that has an abnormal communication between the bile ducts and another organ or anatomic site.
MW, YH
10004665
biliary fistula AE
CTCAE: E11179
NCIt: C79540
a digestive system AE that has subject-reported feeling of uncomfortable fullness of the abdomen.
MW, YH
10005265
bloating AE
CTCAE: E10508
NCIt: C78213
a digestive system AE that has an abnormal communication between the large intestine and another organ or anatomic site.
MW, YH
10009995
colonic fistula AE
CTCAE: E10527
NCIt: C78239
a digestive system AE that has blockage of the normal flow of the intestinal contents in the colon.
MW, YH
10010000
colonic obstruction AE
CTCAE: E10539
NCIt: C78241
a digestive system AE that has a rupture in the colonic wall.
MW, YH
10010001
colonic perforation AE
CTCAE: E10545
NCIt: C78242
a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon.
MW, YH
10010006
colonic ulcer AE
CTCAE: E10556
NCIt: C78244
a duodenum AE that has an abnormal communication between the duodenum and another organ or anatomic site.
MW, YH
10013828
duodenal fistula AE
CTCAE: E10582
NCIt: C78256
a duodenum AE that has blockage of the normal flow of stomach contents through the duodenum.
MW, YH
10013830
duodenal obstruction AE
CTCAE: E10594
NCIt: C79548
a duodenum AE that has a rupture in the duodenal wall.
MW, YH
10013832
duodenal perforation AE
CTCAE: E10600
NCIt: C78259
an esophagus AE that has blockage of the normal flow of the contents in the esophagus.
MW, YH
10015387
esophageal obstruction AE
CTCAE: E10655
NCIt: C78279
an esophagus AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall.
MW, YH
10015451
esophageal ulcer AE
CTCAE: E10676
NCIt: C26950
a digestive system AE that has an abnormal communication between the gallbladder and another organ or anatomic site.
MW, YH
10017631
gallbladder fistula AE
CTCAE: E11189
NCIt: C78305
a digestive system AE that has blockage of the normal flow of the contents of the gallbladder.
MW, YH
10017636
gallbladder obstruction AE
CTCAE: E11198
NCIt: C78308
a gastrointestinal perforation AE that occurs in the stomach wall.
MW, YH
10017815
gastric perforation AE
CTCAE: E10716
NCIt: C78316
a gastrointestinal disoder AE that has an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site.
MW, YH
10017877
gastrointestinal fistula AE
CTCAE: E10749
NCIt: C78319
a gastric AE that has an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine.
MW, YH
10018043
gastroparesis AE
CTCAE: E10759
NCIt: C80512
a digestive system AE that has a narrowing of the lumen of the ileum.
MW, YH
10021307
ileal stenosis AE
CTCAE: E10800
NCIt: C78356
a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum.
MW, YH
10021309
ileal ulcer AE
CTCAE: E10806
NCIt: C78357
a digestive system AE that has a rupture in the jejunal wall.
MW, YH
10023174
jejunal perforation AE
CTCAE: E10840
NCIt: C78399
a digestive system AE that has a narrowing of the lumen of the jejunum.
MW, YH
10023176
jejunal stenosis AE
CTCAE: E10845
NCIt: C78400
a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum.
MW, YH
10023177
jejunal ulcer AE
CTCAE: E10851
NCIt: C78401
a digestive system AE that has inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea.
MW, YH
10025476
malabsorption AE
CTCAE: E10867
NCIt: C3214
a digestive system AE that has blockage of the normal flow of the contents in the stomach.
MW, YH
10029957
obstruction gastric AE
CTCAE: E10882
NCIt: C78505
a digestive system AE that has a rupture in the wall of the extrahepatic or intrahepatic bile duct.
MW, YH
10034405
perforation bile duct AE
CTCAE: E11234
NCIt: C78528
a digestive system AE that has an abnormal communication between the rectum and another organ or anatomic site.
MW, YH
10038062
rectal fistula AE
CTCAE: E10949
NCIt: C79713
a digestive system AE that has a rupture in the rectal wall.
MW, YH
10038073
rectal perforation AE
CTCAE: E10981
NCIt: C78588
a digestive system AE that has a narrowing of the lumen of the rectum.
MW, YH
10038079
rectal stenosis AE
CTCAE: E10986
NCIt: C78589
a digestive system AE that has a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum.
MW, YH
10038080
rectal ulcer AE
CTCAE: E10992
NCIt: C78590
a digestive system AE that has an abnormal communication between a salivary gland and another organ or anatomic site.
MW, YH
10039411
salivary gland fistula AE
CTCAE: E11009
NCIt: C79715
a digestive system AE that has a rupture in the small intestine wall.
MW, YH
10041103
small intestinal perforation AE
CTCAE: E11027
NCIt: C78616
a digestive system AE that has an abnormal communication between the pancreas and another organ or anatomic site.
MW, YH
10049192
pancreatic fistula AE
CTCAE: E10914
NCIt: C79701
a duodenum AE that has a narrowing of the lumen of the duodenum.
MW, YH
10050094
duodenal stenosis AE
CTCAE: E10605
NCIt: C78260
a digestive system AE that has a narrowing of the lumen of the bile duct.
MW, YH
10051341
bile duct stenosis AE
CTCAE: E11173
NCIt: C78182
a gastric disorder AE that has a necrotic process occurring in the gastric wall.
MW, YH
10051886
gastric necrosis AE
CTCAE: E10712
NCIt: C78314
a digestive system AE that has a necrotic process occurring in the pancreas.
MW, YH
10058096
pancreatic necrosis AE
CTCAE: E10926
NCIt: C78522
a digestive system AE that has a necrotic process occurring in the gallbladder.
MW, YH
10059446
gallbladder necrosis AE
CTCAE: E11195
NCIt: C78307
a gastric disorder AE that has a narrowing of the lumen of the stomach.
MW, YH
10061970
gastric stenosis AE
CTCAE: E10721
NCIt: C78317
a digestive system AE that has an abnormal communication between the urinary bladder and the intestine.
MW, YH
10062570
enterovesical fistula AE
CTCAE: E10633
NCIt: C78266
a digestive system AE that has a narrowing of the lumen of the pancreatic duct.
MW, YH
10065703
pancreatic duct stenosis AE
CTCAE: E10908
NCIt: C78519
a digestive system AE that has a necrotic process occurring in the peritoneum.
MW, YH
10065704
peritoneal necrosis AE
CTCAE: E10939
NCIt: C78543
a digestive system AE that has blockage of the normal flow of the intestinal contents in the rectum.
MW, YH
10065707
rectal obstruction AE
CTCAE: E10971
NCIt: C78586
a gastrointestinal disoder AE that has the finding of a necrotic process occurring in the gastrointestinal tract stoma.
MW, YH
10065712
gastrointestinal stoma necrosis
CTCAE: E11721
NCIt: C78321
a gastric disorder AE that has an abnormal communication between the stomach and another organ or anatomic site.
MW, YH
10065713
gastric fistula AE
CTCAE: E10700
NCIt: C79595
a digestive system AE that has an abnormal communication between the jejunum and another organ or anatomic site.
MW, YH
10065719
jejunal fistula AE
CTCAE: E10822
NCIt: C78396
an anus AE that has a necrotic process occurring in the anal region.
MW, YH
10065722
anal necrosis AE
CTCAE: E10482
NCIt: C78171
an esophagus AE that has a necrotic process occurring in the esophageal wall.
MW, YH
10065727
esophageal necrosis AE
CTCAE: E10651
NCIt: C78278
a digestive system AE that has an abnormal communication between the ileum and another organ or anatomic site.
MW, YH
10065728
ileal fistula AE
CTCAE: E10777
NCIt: C78352
a digestive system AE that has blockage of the normal flow of the intestinal contents in the ileum.
MW, YH
10065730
ileal obstruction AE
CTCAE: E10789
NCIt: C78354
a digestive system AE that has blockage of the normal flow of the intestinal contents in the jejunum.
MW, YH
10065732
jejunal obstruction AE
CTCAE: E10834
NCIt: C78398
an esophagus AE that has an abnormal communication between the esophagus and another organ or anatomic site.
MW, YH
10065851
esophageal fistula AE
CTCAE: E10639
NCIt: C79574
an eye AE that has dryness of the cornea and conjunctiva.
MW, YH
10013774
dry eye AE
CTCAE: E10363
NCIt: C34553
an eye AE that has a sudden or brief burst of light.
MW, YH
10016757
flashing lights AE
CTCAE: E10384
NCIt: C50568
an eye AE that has an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens.
MW, YH
10016778
floaters AE
CTCAE: E10388
NCIt: C37955
an eye AE that has an inability to see clearly in dim light.
MW, YH
10029404
night blindness AE
CTCAE: E10401
NCIt: C34850
an eye AE that has a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters.
MW, YH
10038897
retinal tear AE
CTCAE: E10425
NCIt: C50732
an eye AE that has pathological retinal blood vessels that adversely affects vision.
MW, YH
10038901
retinal vascular disorder AE
CTCAE: E10429
NCIt: C35170
an eye AE that has blood extravasation into the vitreous humor.
MW, YH
10047656
vitreous hemorrhage AE
CTCAE: E10447
NCIt: C50469
an eye AE that has excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct.
MW, YH
10047848
watering eyes AE
CTCAE: E10452
NCIt: C78717
an eye AE that has involvement of the optic nerve (second cranial nerve).
MW, YH
10061322
optic nerve disorder AE
CTCAE: E10406
NCIt: C79698
an eye AE that has involvement of the sclera of the eye.
MW, YH
10061510
scleral disorder AE
CTCAE: E10437
NCIt: C79717
an ear AE that has dizziness, imbalance, nausea, and vision problems.
MW, YH
10047386
vestibular disorder AE
CTCAE: E10295
NCIt: C27166
an ear pain AE that has a sensation of marked discomfort in the external ear region.
MW, YH
10065785
external ear pain AE
CTCAE: E10272
NCIt: C78285
a cardiovascular AE that has a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action.
MW, YH
10010783
constrictive pericarditis AE
CTCAE: E10120
NCIt: C78246
a cardiovascular AE that has a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness.
MW, YH
10040639
sick sinus syndrome AE
CTCAE: E10202
NCIt: C62244
a cardiovascular AE that has an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium.
MW, YH
10053565
pericardial tamponade AE
CTCAE: E10177
NCIt: C50481
a cardiovascular AE that has a defect in tricuspid valve function or structure.
MW, YH
10061389
tricuspid valve disease AE
CTCAE: E10224
NCIt: C78649
a cardiovascular AE that has a defect in mitral valve function or structure.
MW, YH
10061532
mitral valve disease AE
CTCAE: E10134
NCIt: C78446
a cardiovascular AE that has a defect in pulmonary valve function or structure.
MW, YH
10061541
pulmonary valve disease AE
CTCAE: E10186
NCIt: C78579
a cardiovascular AE that has a defect in aortic valve function or structure.
MW, YH
10061589
aortic valve disease AE
CTCAE: E10071
NCIt: C78650
a bone AE that has a change in tooth hue or tint.
MW, YH
10044031
tooth discoloration AE
CTCAE: E11052
NCIt: C80112
an edema AE that has swelling due to an accumulation of excessive fluid in the neck.
MW, YH
10054482
neck edema AE
CTCAE: E11159
NCIt: C78501
an edema AE that has swelling due to excessive fluid accumulation in the trunk area.
MW, YH
10058720
edema trunk AE
CTCAE: E11090
NCIt: C78263
an inflammation AE that has inflammation of the rectum.
MW, YH
10036774
proctitis AE
CTCAE: E10943
NCIt: C38011
an inflammation AE that has inflammation of the mucous membrane of the rectum
MW, YH
10063190
rectal mucositis AE
CTCAE: E10961
NCIt: C78584
an inflammation AE that has inflammation of the mucous membrane of the anus.
MW, YH
10065721
anal mucositis AE
CTCAE: E10476
NCIt: C78170
an inflammation AE that has inflammation, swelling and redness to the outer ear and ear canal.
MW, YH
10065837
external ear inflammation AE
CTCAE: E10266
NCIt: C79601
an inflammation AE that has inflammation (physiologic response to irritation), swelling and redness to the middle ear.
MW, YH
10065838
middle ear inflammation AE
CTCAE: E10281
NCIt: C34885
a death AE that has cessation of life occurring during the first 28 days of life.
MW, YH
10011912
death neonatal AE
CTCAE: E11078
NCIt: C80082
a fracture AE that has a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot.
MW, YH
10002544
ankle fracture AE
CTCAE: E11640
NCIt: C26989
a fracture AE that has the finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken.
MW, YH
10020100
hip fracture AE
CTCAE: E11726
NCIt: C26794
a fracture AE that has the finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken.
MW, YH
10041569
spinal fracture AE
CTCAE: E11954
NCIt: C80516
a fracture AE that has the finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken.
MW, YH
10048049
wrist fracture AE
CTCAE: E12069
NCIt: C80517
a lung infection AE that has an infectious process involving the bronchi.
MW, YH
10055078
bronchial infection AE
CTCAE: E11323
NCIt: C2911
a muscle enzyme level increased AE that has the finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen.
MW, YH
10011268
CPK increased AE
CTCAE: E12132
NCIt: C78247
a recall phenomenon AE that has the finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent.
MW, YH
10037767
radiation recall reaction (dermatologic) AE
CTCAE: E11926
NCIt: C78580
an immunology and allergy investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen.
MW, YH
10007839
CD4 lymphocytes decreased AE
CTCAE: E12122
NCIt: C78233
a respiratory and pulmonary investigation result abnormal AE that has the finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value.
MW, YH
10047580
vital capacity abnormal AE
CTCAE: E12220
NCIt: C78715
a respiratory and pulmonary investigation result abnormal AE that has the finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide.
MW, YH
10065906
carbon monoxide diffusing capacity decreased AE
CTCAE: E12112
NCIt: C78229
an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen.
MW, YH
10005332
blood antidiuretic hormone abnormal AE
CTCAE: E12092
NCIt: C78214
an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen.
MW, YH
10005452
blood corticotrophin decreased AE
CTCAE: E12101
NCIt: C78215
an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen.
MW, YH
10005561
blood gonadotrophin abnormal AE
CTCAE: E12105
NCIt: C78216
an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen.
MW, YH
10005778
blood prolactin abnormal AE
CTCAE: E12109
NCIt: C78217
an endocrine investigation result abnormal AE that has the finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen.
MW, YH
10018748
growth hormone abnormal AE
CTCAE: E12166
NCIt: C78327
an enzyme investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen.
MW, YH
10062646
pancreatic enzymes decreased AE
CTCAE: E12203
NCIt: C78520
a hematology investigation result abnormal AE that has the finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen.
MW, YH
10016596
fibrinogen decreased AE
CTCAE: E12151
NCIt: C78300
a hematology investigation result abnormal with the finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen.
MW, YH
10019150
haptoglobin decreased AE
CTCAE: E12169
NCIt: C78330
a coronary heart disease AE that has signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction.
MW, YH
10051592
acute coronary syndrome AE
CTCAE: E10066
NCIt: C53652
an eyelid disorder AE that has impaired eyelid function.
MW, YH
10061145
eyelid function disorder AE
CTCAE: E10380
NCIt: C78288
an injury AE that has the finding of damage to the aorta.
MW, YH
10002899
aortic injury AE
CTCAE: E11644
NCIt: C35623
an injury AE that has the finding of damage to an artery
MW, YH
10003162
arterial injury AE
CTCAE: E11648
NCIt: C35401
an injury AE that has the finding of damage to the carotid artery.
MW, YH
10022161
injury to carotid artery AE
CTCAE: E11730
NCIt: C79599
an injury AE that has the finding of damage to the inferior vena cava.
MW, YH
10022213
injury to inferior vena cava AE
CTCAE: E11734
NCIt: C78363
an injury AE that has the finding of damage to the superior vena cava.
MW, YH
10022356
injury to superior vena cava AE
CTCAE: E11741
NCIt: C78365
an injury AE that has the finding of damage to the gastrointestinal system during a surgical procedure.
MW, YH
10065825
intraoperative gastrointestinal injury AE
CTCAE: E11798
NCIt: C78380
an injury AE that has the finding of damage to an artery during a surgical procedure.
MW, YH
10065826
intraoperative arterial injury AE
CTCAE: E11770
NCIt: C78375
an injury AE that has the finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure.
MW, YH
10065827
intraoperative hepatobiliary injury AE
CTCAE: E11814
NCIt: C78382
an injury AE that has the finding of damage to the urinary system during a surgical procedure.
MW, YH
10065828
intraoperative urinary injury AE
CTCAE: E11867
NCIt: C78391
an injury AE that has the finding of damage to the musculoskeletal system during a surgical procedure.
MW, YH
10065829
intraoperative musculoskeletal injury AE
CTCAE: E11820
NCIt: C78383
an injury AE that has the finding of damage to the nervous system during a surgical procedure.
MW, YH
10065830
intraoperative neurological injury AE
CTCAE: E11826
NCIt: C78384
an injury AE that has the finding of damage to the breast parenchyma during a surgical procedure.
MW, YH
10065831
intraoperative breast injury AE
CTCAE: E11776
NCIt: C78376
an injury AE that has the finding of damage to the respiratory system during a surgical procedure.
MW, YH
10065832
intraoperative respiratory injury AE
CTCAE: E11850
NCIt: C78388
an injury AE that has the finding of damage to the endocrine gland during a surgical procedure.
MW, YH
10065834
intraoperative endocrine injury AE
CTCAE: E11792
NCIt: C78379
an injury AE that has the finding of damage to the reproductive organs during a surgical procedure.
MW, YH
10065840
intraoperative reproductive tract injury AE
CTCAE: E11844
NCIt: C78387
an injury AE that has the finding of damage to the eye during a surgical procedure.
MW, YH
10065841
intraoperative ocular injury AE
CTCAE: E11832
NCIt: C78385
an injury AE that has the finding of damage to the head and neck during a surgical procedure.
MW, YH
10065842
lintraoperative head and neck injury AE
CTCAE: E11804
NCIt: C78381
an injury AE that has the finding of damage to the heart during a surgical procedure.
MW, YH
10065843
intraoperative cardiac injury AE
CTCAE: E11782
NCIt: C78377
an injury AE that has the finding of damage to the ear during a surgical procedure.
MW, YH
10065844
intraoperative ear injury AE
CTCAE: E11786
NCIt: C78378
an injury AE that has the finding of damage to the kidney during a surgical procedure.
MW, YH
10065845
intraoperative renal injury AE
CTCAE: E11838
NCIt: C78386
an injury AE finding of damage to the skin during a surgical procedure.
MW, YH
10065846
intraoperative skin injury AE
CTCAE: E11856
NCIt: C78389
an injury AE that has the finding of damage to the spleen during a surgical procedure.
MW, YH
10065847
intraoperative splenic injury AE
CTCAE: E11862
NCIt: C78390
an injury AE that has the finding of damage to a vein during a surgical procedure.
MW, YH
10065848
intraoperative venous injury AE
CTCAE: E11873
NCIt: C78392
an injury AE that has the finding of damage to the jugular vein.
MW, YH
10065849
injury to jugular vein AE
CTCAE: E11737
NCIt: C78364
an appendicitis AE that has acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.
MW, YH
10003012
appendicitis perforated AE
CTCAE: E11296
NCIt: C78178
a troponin AE which indicates increased levels of cardiac troponin T in a biological specimen
MW, YH
10007613
cardiac troponin T increased
CTCAE: E12119
NCIt: C78231
an eye infection AE that has an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes.
MW, YH
10010742
conjunctivitis infective AE
CTCAE: E11342
NCIt: C35704
an eye infection AE that has an infectious process involving the internal structures of the eye.
MW, YH
10014801
endophthalmitis AE
CTCAE: E11377
NCIt: C34586
an eye infection AE that has an infectious process involving the orbit of the eye.
MW, YH
10051472
periorbital infection AE
CTCAE: E11511
NCIt: C78531
an eye infection AE that has an infectious process involving the cornea.
MW, YH
10061788
corneal infection AE
CTCAE: E11347
NCIt: C26805
a fatigue AE that has fatigue relieved by rest
MW, YH
Grade 1 fatigue AE
CTCAE: E11099
a fatigue AE that has fatigue not relieved by rest; limiting instrumental activities of daily living
MW, YH
Grade 2 fatigue AE
CTCAE: E11100
a fatigue AE that has fatigue not relieved by rest, limiting self care activities of daily living
MW, YH
Grade 3 fatigue AE
CTCAE: E11101
a myocardial infarction AE that has asymptomatic and cardiac enzymes minimally abnormal and no evidence of ischemic ECG changes
MW, YH
Grade 2 myocardial infarction AE
CTCAE: E10153
a myocardial infarction AE that has severe symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction
MW, YH
Grade 3 myocardial infarction AE
CTCAE: E10154
a pancreatitis AE that has enzyme elevation or radiologic findings only
MW, YH
Grade 3 pancreatitis AE
CTCAE: E10931
a pancreatitis AE that has severe pain; vomiting; medical intervention indicated (e.g., analgesia, nutritional support)
MW, YH
Grade 3 pancreatitis AE
CTCAE: E10932
an activated partial thromboplastin time prolonged AE that is greater than the upper limit of normal to 1.5 times the upper limit of normal
MW, YH
Grade 1 activated partial thromboplastin time prolonged AE
CTCAE: E12074
an activated partial thromboplastin time prolonged AE that is 1.5-2.5 times the upper limit of normal
MW, YH
Grade 2 activated partial thromboplastin time prolonged AE
CTCAE: E12075
an activated partial thromboplastin time prolonged AE that is greater than 2.5 times the upper limit of normal; hemorrhage
MW, YH
Grade 3 activated partial thromboplastin time prolonged AE
CTCAE: E12076
an alanine aminotransferase level increased AE that is greater than the upper limit of normal to 3 times the upper limit of normal
MW, YH
Grade 1 alanine aminotransferase level increased AE
CTCAE: E12078
an alanine aminotransferase level increased AE that is greater than 3 to 5 times the upper limit of normal
MW, YH
Grade 2 alanine aminotransferase level increased AE
CTCAE: E12079
an alanine aminotransferase level increased AE that is greater than 5 to 20 times the upper limit of normal
MW, YH
Grade 3 alanine aminotransferase level increased AE
CTCAE: E12080
an alanine aminotransferase level increased AE that is greater than 20 times the upper limit of normal
MW, YH
Grade 4 alanine aminotransferase level increased AE
CTCAE: E12081
an anal ulcer AE that is symptomatic; altered GI function
MW, YH
Grade 2 anal ulcer AE
CTCAE: E10498
an anal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling
MW, YH
Grade 3 anal ulcer AE
CTCAE: E10499
an atrial flutter AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation
MW, YH
Grade 3 atrial flutter AE
CTCAE: E10090
an otitis media AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 otitis media AE
CTCAE: E11478
an otitis media AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 otitis media AE
CTCAE: E11479
a pericarditis AE that has asymptomatic, ECG or physical findings (e.g., rub) consistent with pericarditis
MW, YH
Grade 1 pericarditis AE
CTCAE: E10181
a pericarditis AE that has symptomatic pericarditis (e.g., chest pain)
MW, YH
Grade 2 pericarditis AE
CTCAE: E10182
a pericarditis AE that has pericarditis with physiologic consequences (e.g., pericardial constriction)
MW, YH
Grade 3 pericarditis AE
CTCAE: E10183
a pharyngitis AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 pharyngitis AE
CTCAE: E11526
a pharyngitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 pharyngitis AE
CTCAE: E11527
a fever AE that has 38.0 - 39.0 degrees C (100.4 - 102.2 degrees F)
MW, YH
Grade 1 fever AE
CTCAE: E11103
a fever AE that has greater than 39.0 - 40.0 degrees C (102.3 - 104.0 degrees F)
MW, YH
Grade 2 fever AE
CTCAE: E11104
a fever AE that has greater than 40.0 degrees C (greater than104.0 degrees F) for less than or equal to 24 hrs
MW, YH
Grade 3 fever AE
CTCAE: E11105
a fever AE that has greater than 40.0 degrees C (greater than104.0 degrees F) for more than 24 hrs
MW, YH
Grade 4 fever AE
CTCAE: E11106
an injection-site adverse event characterized by tenderness with or without associated symptoms (e.g., warmth, erythema, itching)
MW, YH
Grade 1 injection-site adverse event
CTCAE: E11139
an injection-site adverse event characterized by pain; lipodystrophy; edema; phlebitis
MW, YH
Grade 2 injection-site adverse event
CTCAE: E11140
an injection-site adverse event characterized by ulceration or necrosis; severe tissue damage; operative intervention indicated
MW, YH
Grade 3 injection-site adverse event
CTCAE: E11141
a leukocyte cell number increased AE where leukocytes are greater than 100,000/mm3
MW, YH
Grade 3 leukocytosis AE
CTCAE: E10049
a leukocyte cell number increased AE that has clinical manifestations of leucostasis; urgent intervention indicated
MW, YH
Grade 4 leukocytosis AE
CTCAE: E10050
a leukocyte cell number decreased AE that is less than the lower limit of normal - 3000/mm3; less than the lower limit of normal - 3.0 x 10e9 /L
MW, YH
Grade 1 leukocyte cell number decreased AE
CTCAE: E12233
a leukocyte cell number decreased AE that is less than 3000 - 2000/mm3; less than 3.0 - 2.0 x 10e9 /L
MW, YH
Grade 2 leukocyte cell number decreased AE
CTCAE: E12234
a leukocyte cell number decreased AE that is less than 2000 - 1000/mm3; less than 2.0 - 1.0 x 10e9 /L
MW, YH
Grade 3 leukocyte cell number decreased AE
CTCAE: E12235
a leukocyte cell number decreased AE that is less than 1000/mm3; less than 1.0 x 10e9 /L
MW, YH
Grade 4 leukocyte cell number decreased AE
CTCAE: E12236
a malaise AE that has uneasiness or lack of well being
MW, YH
Grade 1 malaise AE
CTCAE: E11153
a malaise AE that has uneasiness or lack of well being; limiting instrumental activities of daily living
MW, YH
Grade 2 malaise AE
CTCAE: E11154
a chills AE that has mild sensation of cold; shivering; chattering of teeth
MW, YH
Grade 1 chills AE
CTCAE: E11075
A chills AE that has moderate tremor of the entire body; narcotics indicated
MW, YH
Grade 2 chills AE
CTCAE: E11076
a chills AE that has severe or prolonged, not responsive to narcotics
MW, YH
Grade 3 chills AE
CTCAE: E11077
an edema face AE that has localized facial edema
MW, YH
Grade 1 edema face AE
CTCAE: E11083
a meningitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated; focal neurologic deficit
MW, YH
Grade 3 meningitis AE
CTCAE: E11459
a serum sickness AE that has moderate arthralgia; fever, rash, urticaria, antihistamines indicated
MW, YH
Grade 2 serum sickness AE
CTCAE: E11278
a serum sickness AE that has severe arthralgia or arthritis; extensive rash; steroids or IV fluids indicated
MW, YH
Grade 3 serum sickness AE
CTCAE: E11279
a urinary tract infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 urinary tract infection AE
CTCAE: E11615
a urinary tract infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 urinary tract infection AE
CTCAE: E11616
a laryngitis AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 laryngitis AE
CTCAE: E11436
a laryngitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 laryngitis AE
CTCAE: E11437
a dry mouth AE that is symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow greater than0.2 ml/min
MW, YH
Grade 1 dry mouth AE
CTCAE: E10579
a dry mouth AE that has moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min
MW, YH
Grade 2 dry mouth AE
CTCAE: E10580
a dry mouth AE that has the inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min
MW, YH
Grade 3 dry mouth AE
CTCAE: E10581
a pustular rash AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 pustular rash AE
CTCAE: E11546
a pustular rash AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 pustular rash AE
CTCAE: E11547
a flatulence AE that has moderate; persistent; psychosocial sequelae
MW, YH
Grade 2 flatulence AE
CTCAE: E10699
a weight loss AE that is 5 to less than 10% from baseline; intervention not indicated
MW, YH
Grade 1 weight loss AE
CTCAE: E12229
a weight loss AE that is 10 - less than 20% from baseline; nutritional support indicated
MW, YH
Grade 2 weight loss AE
CTCAE: E12230
a weight loss AE that is greater than or equal to 20% from baseline; tube feeding or TPN indicated
MW, YH
Grade 3 weight loss AE
CTCAE: E12231
an abnormal gait AE that has mild change in gait (e.g., wide-based, limping or hobbling)
MW, YH
Grade 1 abnormal gait AE
CTCAE: E11113
an abnormal gait AE that has moderate change in gait (e.g., wide-based, limping or hobbling); assistive device indicated; limiting instrumental activities of daily living
MW, YH
Grade 2 abnormal gait AE
CTCAE: E11114
an anemia AE where hemoglobin (Hgb) is less than the lower limit of normal (LLN), which is 10.0 g/dL, 6.2 mmol/L, or 100 g/L.
MW, YH
Grade 1 anemia AE
CTCAE: E10011
an anemia AE where hemoglobin (Hgb) is less than 10.0-8.0 g/dL, 6.2 -4.9 mmol/L, or 100 - 80 g/L.
MW, YH
Grade 2 anemia AE
CTCAE: E10012
an anemia AE where hemoglobin (Hgb) is less than 8.0 g/dL, 4.9 mmol/L, or 80 g/L.
MW, YH
Grade 3 anemia AE
CTCAE: E10013
a sinusitis AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 sinusitis AE
CTCAE: E11564
a sinusitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 sinusitis AE
CTCAE: E11565
an allergy AE that has transient flushing or rash, drug fever <38 degrees C (<100.4 degrees F); intervention not indicated
MW, YH
Grade 1 allergy AE
CTCAE: E11249
an allergy AE where intervention or infusion interruption indicated; responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics); prophylactic medications indicated for less than or equal to 24 hrs
MW, YH
Grade 2 allergy AE
CTCAE: E11250
an allergy AE that is prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates)
MW, YH
Grade 3 allergy AE
CTCAE: E11251
a dysphagia AE that is symptomatic, able to eat regular diet
MW, YH
Grade 1 dysphagia AE
CTCAE: E10622
a dysphagia AE that is symptomatic and altered eating/swallowing
MW, YH
Grade 2 dysphagia AE
CTCAE: E10623
a dysphagia AE that has severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated
MW, YH
Grade 3 dysphagia AE
CTCAE: E10624
a platelet count decreased AE that is less than the lower limit of normal - 75,000/mm3; less than the lower limit of normal - 75.0 x 10e9 /L
MW, YH
Grade 1 platelet count decreased AE
CTCAE: E12208
a platelet count decreased AE that is less than 75,000 - 50,000/mm3; less than 75.0 - 50.0 x 10e9 /L
MW, YH
Grade 2 platelet count decreased AE
CTCAE: E12209
a platelet count decreased AE that is less than 50,000 - 25,000/mm3; less than 50.0 - 25.0 x 10e9 /L
MW, YH
Grade 3 platelet count decreased AE
CTCAE: E12210
a platelet count decreased AE that is less than 25,000/mm3; less than 25.0 x 10e9 /L
MW, YH
Grade 4 platelet count decreased AE
CTCAE: E12211
a vomiting AE that has 1 - 2 episodes (separated by 5 minutes) in 24 hrs
MW, YH
Grade 1 vomiting AE
CTCAE: E11069
a vomiting AE that has 3 - 5 episodes (separated by 5 minutes) in 24 hrs
MW, YH
Grade 2 vomiting AE
CTCAE: E11070
a vomiting AE that has 6 or more episodes (separated by 5 minutes) in 24 hrs; tube feeding, TPN or hospitalization indicated
MW, YH
Grade 3 vomiting AE
CTCAE: E11071
a constipation AE that has occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema
MW, YH
Grade 1 constipation AE
CTCAE: E10563
a constipation AE that has persistent symptoms with regular use of laxatives or enemas; limiting instrumental activities of daily living
MW, YH
Grade 2 constipation AE
CTCAE: E10564
a constipation AE that has obstipation with manual evacuation indicated; limiting self care activities of daily living
MW, YH
Grade 3 constipation AE
CTCAE: E10565
a lymphocyte count increased AE that is greater than 4000/mm3 - 20,000/mm3
MW, YH
Grade 2 lymphocyte count increased AE
CTCAE: E12196
a lymphocyte count increased AE that is greater than 20,000/mm3
MW, YH
Grade 3 lymphocyte count increased AE
CTCAE: E12197
a hypothermia AE that has 35 - greater than 32 degrees C; 95 - greater than 89.6 degrees F
MW, YH
Grade 2 hypothermia AE
CTCAE: E11123
a hypothermia AE that has 32 - greater than 28 degrees C; 89.6 - greater than 82.4 degrees F
MW, YH
Grade 3 hypothermia AE
CTCAE: E11124
a hypothermia AE that has less than or equal to 28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation)
MW, YH
Grade 4 hypothermia AE
CTCAE: E11125
a hematoma AE that is localized or in a dependent area
MW, YH
Grade 1 hematoma AE
CTCAE: E11667
a hematoma AE that is generalized
MW, YH
Grade 2 hematoma AE
CTCAE: E11668
an aspartate aminotransferase level increased AE that is greater than the upper limit of normal to 3 times the upper limit of normal
MW, YH
Grade 1 aspartate aminotransferase level increased AE
CTCAE: E12088
an aspartate aminotransferase level increased AE that is greater than 3 to 5 times the upper limit of normal
MW, YH
Grade 2 aspartate aminotransferase level increased AE
CTCAE: E12089
an aspartate aminotransferase level increased AE that is greater than 5 to 20 times the upper limit of normal
MW, YH
Grade 3 aspartate aminotransferase level increased AE
CTCAE: E12090
an aspartate aminotransferase level increased AE that is greater than 20 times the upper limit of normal
MW, YH
Grade 4 aspartate aminotransferase level increased AE
CTCAE: E12091
an atrial fibrillation AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation
MW, YH
Grade 3 atrial fibrillation AE
CTCAE: E10084
a blood alkaline phosphatase increased AE that is greater than the upper limit of normal to 2.5 times the upper limit of normal
MW, YH
Grade 1 blood alkaline phosphatase increased AE
CTCAE: E12083
a blood alkaline phosphatase increased AE that is greater than 2.5 to 5 times the upper limit of normal
MW, YH
Grade 2 blood alkaline phosphatase increased AE
CTCAE: E12084
a blood alkaline phosphatase increased AE that is greater than 5 to 20 times the upper limit of normal
MW, YH
Grade 3 blood alkaline phosphatase increased AE
CTCAE: E12085
a blood alkaline phosphatase increased AE that is greater than 20 times the upper limit of normal
MW, YH
Grade 4 blood alkaline phosphatase increased AE
CTCAE: E12086
a blood amylase level increased AE that is greater than the upper limit of normal - 1.5 times the upper limit of normal
MW, YH
Grade 1 blood amylase level increased AE
CTCAE: E12213
a blood amylase level increased AE that is greater than 1.5 - 2.0 times the upper limit of normal
MW, YH
Grade 2 blood amylase level increased AE
CTCAE: E12214
a blood amylase level increased AE that is greater than 2.0 - 5.0 times the upper limit of normal
MW, YH
Grade 3 blood amylase level increased AE
CTCAE: E12215
a blood amylase level increased AE that is greater than 5.0 times the upper limit of normal
MW, YH
Grade 4 blood amylase level increased AE
CTCAE: E12216
a blood bilirubin level increased AE that is greater than the upper limit of normal to 1.5 times the upper limit of normal
MW, YH
Grade 1 blood bilirubin level increased AE
CTCAE: E12097
a blood bilirubin level increased AE that is greater than 1.5 to 3 times the upper limit of normal
MW, YH
Grade 2 blood bilirubin level increased AE
CTCAE: E12098
a blood bilirubin level increased AEgreater than3.0 - 10.0 x upper limit of normal
MW, YH
Grade 3 blood bilirubin level increased AE
CTCAE: E12099
a blood bilirubin level increased AE that is greater than 10 times the upper limit of normal
MW, YH
Grade 4 blood bilirubin level increased AE
CTCAE: E12100
a blood cholesterol increased AE that is greater than the upper limit of normal to 300 mg/dL; greater than the upper limit of normal to 7.75 mmol/L
MW, YH
Grade 1 blood cholesterol increased AE
CTCAE: E12128
a blood cholesterol increased AE that is greater than 300 - 400 mg/dL; greater than 7.75 - 10.34 mmol/L
MW, YH
Grade 2 blood cholesterol increased AE
CTCAE: E12129
a blood cholesterol increased AE that is greater than 400 - 500 mg/dL; greater than 10.34 - 12.92 mmol/L
MW, YH
Grade 3 blood cholesterol increased AE
CTCAE: E12130
a blood cholesterol increased AE that is greater than 500 mg/dL; greater than 12.92 mmol/L
MW, YH
Grade 4 blood cholesterol increased AE
CTCAE: E12131
a blood creatinine level increased AE that is greater than 1 - 1.5 times the baseline; greater than the upper limit of normal - 1.5 times the upper limit of normal
MW, YH
Grade 1 blood creatinine level increased AE
CTCAE: E12138
a blood creatinine level increased AE that is greater than 1.5 - 3.0 times the baseline; greater than 1.5 - 3.0 times the upper limit of normal
MW, YH
Grade 2 blood creatinine level increased AE
CTCAE: E12139
a blood creatinine level increased AE that is greater than 3.0 times the baseline; greater than 3.0 - 6.0 times the upper limit of normal
MW, YH
Grade 3 blood creatinine level increased AE
CTCAE: E12140
a blood creatinine level increased AE that is greater than 6.0 times the upper limit of normal
MW, YH
Grade 4 blood creatinine level increased AE
CTCAE: E12141
a bone marrow depression AE categorized as mildly hypocellular or less than or equal to 25% reduction from normal cellularity for age
MW, YH
Grade 1 bone marrow depression AE
CTCAE: E10023
a bone marrow depression AE categorized as moderately hypocellular or greater than 25 to less than 50% reduction from normal cellularity for age
MW, YH
Grade 2 bone marrow depression AE
CTCAE: E10024
a bone marrow depression AE cateogirzed as severely hypocellular or greater than 50 to less than or equal to 75% reduction cellularity from normal for age
MW, YH
Grade 3 bone marrow depression AE
CTCAE: E10025
a bone marrow depression AE categorized as aplastic persistent for longer than 2 weeks
MW, YH
Grade 4 bone marrow depression AE
CTCAE: E10026
a breast infection AE that has local infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 breast infection AE
CTCAE: E11319
a breast infection AE that has severe infection; axillary adenitis; IV antibacterial, antifungal, or antiviral intervention indicated
MW, YH
Grade 3 breast infection AE
CTCAE: E11320
a cardiac failure AE that is asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities
MW, YH
Grade 1 cardiac failure AE
CTCAE: E10125
a cardiac failure AE that has symptoms with mild to moderate activity or exertion
MW, YH
Grade 2 cardiac failure AE
CTCAE: E10126
a cardiac failure AE that has severe with symptoms at rest or with minimal activity or exertion; intervention indicated
MW, YH
Grade 3 cardiac failure AE
CTCAE: E10127
a cardiac failure AE that has life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support)
MW, YH
Grade 4 cardiac failure AE
CTCAE: E10128
a cataract AE that is symptomatic; moderate decrease in visual acuity (20/40 or better)
MW, YH
Grade 2 cataract AE
CTCAE: E10352
a cataract AE that is symptomatic with marked decrease in visual acuity (worse than 20/40 but better than 20/200); operative intervention indicated (e.g., cataract surgery)
MW, YH
Grade 3 cataract AE
CTCAE: E10353
a cataract AE that is characterized by blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 cataract AE
CTCAE: E10354
a catheter related infection AE that is localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 catheter related infection AE
CTCAE: E11329
a catheter related infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 catheter related infection AE
CTCAE: E11330
a colitis AE that has abdominal pain; mucus or blood in stool
MW, YH
Grade 2 colitis AE
CTCAE: E10523
a colitis AE that has severe abdominal pain; change in bowel habits; medical intervention indicated; peritoneal signs
MW, YH
Grade 3 colitis AE
CTCAE: E10524
a cytokine release syndrome AE that has a mild reaction; infusion interruption not indicated; intervention not indicated
MW, YH
Grade 1 cytokine release syndrome AE
CTCAE: E11265
a cytokine release syndrome AE where therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for less than or equal to 24 hrs
MW, YH
Grade 2 cytokine release syndrome AE
CTCAE: E11266
a cytokine release syndrome AEthat is prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates)
MW, YH
Grade 3 cytokine release syndrome AE
CTCAE: E11267
a dental caries AE that has one or more dental caries, not involving the root
MW, YH
Grade 1 dental caries AE
CTCAE: E10569
a dental caries AE that has dental caries involving the root
MW, YH
Grade 2 dental caries AE
CTCAE: E10570
a dental caries AE that has dental caries resulting in pulpitis or periapical abscess or resulting in tooth loss
MW, YH
Grade 3 dental caries AE
CTCAE: E10571
a device related infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 device related infection AE
CTCAE: E11357
a disseminated intravascular coagulation AE that has laboratory findings with no bleeding
MW, YH
Grade 2 disseminated intravascular coagulation AE
CTCAE: E10029
a disseminated intravascular coagulation AE that has laboratory findings and bleeding
MW, YH
Grade 3 disseminated intravascular coagulation AE
CTCAE: E10030
an ejection fraction decreased AE where the resting ejection fraction (EF) 50 - 40%; 10 - 19% drop from baseline
MW, YH
Grade 2 ejection fraction decreased AE
CTCAE: E12143
an ejection fraction decreased AE where the resting ejection fraction (EF) 39 - 20%; greater than 20% drop from baseline
MW, YH
Grade 3 ejection fraction decreased AE
CTCAE: E12144
an ejection fraction decreased AE where the resting ejection fraction (EF) less than 20%
MW, YH
Grade 4 ejection fraction decreased AE
CTCAE: E12145
an electrocardiogram qt prolonged AE where the QTc 450 - 480 ms
MW, YH
Grade 1 electrocardiogram qt prolonged AE
CTCAE: E12147
an electrocardiogram qt prolonged AE where the QTc 481 - 500 ms
MW, YH
Grade 2 electrocardiogram qt prolonged AE
CTCAE: E12148
an electrocardiogram qt prolonged AE where the QTc is greater than or equal to 501 ms on at least two separate ECGs
MW, YH
Grade 3 electrocardiogram qt prolonged AE
CTCAE: E12149
an electrocardiogram qt prolonged AE where the QTc is greater than or equal to 501 or greater than 60 ms change from baseline and Torsade de pointes or polymorphic ventricular tachycardia or signs/symptoms of serious arrhythmia
MW, YH
Grade 4 electrocardiogram qt prolonged AE
CTCAE: E12150
an enterocolitis AE that has abdominal pain; mucus or blood in stool
MW, YH
Grade 2 enterocolitis AE
CTCAE: E10629
an enterocolitis AE that has severe or persistent abdominal pain; fever; ileus; peritoneal signs
MW, YH
Grade 3 enterocolitis AE
CTCAE: E10630
a fall AE that is minor with no resultant injuries; intervention not indicated
MW, YH
Grade 1 fall AE
CTCAE: E11688
a fall AE where hospitalization indicated
MW, YH
Grade 3 fall AE
CTCAE: E11690
a febrile neutropenia AE categorized as anC less than 1000/mm3 with a single temperature of greater than 38.3 degrees C (101 degrees F) or a sustained temperature of greater than or equal to 38 degrees C (100.4 degrees F) for more than one hour.
MW, YH
Grade 3 febrile neutropenia AE
CTCAE: E10034
a forced expiratory volume decreased AE where FEV1% (percentages of observed FEV1 and FVC related to their respective predicted values) 99 - 70% predicted
MW, YH
Grade 1 forced expiratory volume decreased AE
CTCAE: E12157
a forced expiratory volume decreased AE where FEV1 60 - 69%
MW, YH
Grade 2 forced expiratory volume decreased AE
CTCAE: E12158
a forced expiratory volume decreased AE where FEV1 50 - 59%
MW, YH
Grade 3 forced expiratory volume decreased AE
CTCAE: E12159
a forced expiratory volume decreased AE where FEV1 is less than or equal to 49%
MW, YH
Grade 4 forced expiratory volume decreased AE
CTCAE: E12160
a fracture AE that is symptomatic but non-displaced; immobilization indicated
MW, YH
Grade 2 fracture AE
CTCAE: E11705
a fracture AE that has severe symptoms; displaced or open wound with bone exposure; disabling; operative intervention indicated
MW, YH
Grade 3 fracture AE
CTCAE: E11706
a gamma-glutamyltransferase level increased AE that is greater than the upper limit of normal - 2.5 times upper limit of normal
MW, YH
Grade 1 gamma-glutamyltransferase level increased AE
CTCAE: E12162
a gamma-glutamyltransferase level increased AE that is greater than 2.5 - 5.0 times the upper limit of normal
MW, YH
Grade 2 gamma-glutamyltransferase level increased AE
CTCAE: E12163
a gamma-glutamyltransferase level increased AE that is greater than 5.0 - 20.0 times the upper limit of normal
MW, YH
Grade 3 gamma-glutamyltransferase level increased AE
CTCAE: E12164
a gamma-glutamyltransferase level increased AE that is greater than 20.0 times the upper limit of normal
MW, YH
Grade 4 gamma-glutamyltransferase level increased AE
CTCAE: E12165
a gastric ulcer AE that is symptomatic; altered GI function; medical intervention indicated; limiting instrumental activities of daily living
MW, YH
Grade 2 gastric ulcer AE
CTCAE: E10729
a gastric ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care activities of daily living; disabling
MW, YH
Grade 3 gastric ulcer AE
CTCAE: E10730
a gastritis AE that is symptomatic; altered GI function; medical intervention indicated
MW, YH
Grade 2 gastritis AE
CTCAE: E10735
a gastritis AE that has severely altered eating or gastric function; TPN or hospitalization indicated
MW, YH
Grade 3 gastritis AE
CTCAE: E10736
a hemolytic uremic syndrome AE that has evidence of RBC destruction (schistocytosis) without clinical consequences
MW, YH
Grade 1 hemolytic uremic syndrome AE
CTCAE: E10044
a hemolytic uremic syndrome AE that has laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)
MW, YH
Grade 3 hemolytic uremic syndrome AE
CTCAE: E10045
a hemolytic uremic syndrome AE that has life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure)
MW, YH
Grade 4 hemolytic uremic syndrome AE
CTCAE: E10046
a hemorrhoidal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 hemorrhoidal hemorrhage AE
CTCAE: E10770
a hepatic failure AE that has asterixis; mild encephalopathy; limiting self care activities of daily living
MW, YH
Grade 3 hepatic failure AE
CTCAE: E11212
a hepatic failure AE that has moderate to severe encephalopathy; coma; life-threatening consequences
MW, YH
Grade 4 hepatic failure AE
CTCAE: E11213
a hepatitis viral AE that has symptomatic liver dysfunction; fibrosis by biopsy; compensated cirrhosis; reactivation of chronic hepatitis
MW, YH
Grade 3 hepatitis viral AE
CTCAE: E11412
a hepatitis viral AE that has decompensated liver function (e.g., ascites, coagulopathy, encephalopathy, coma)
MW, YH
Grade 4 hepatitis viral AE
CTCAE: E11413
an ileus AE that is symptomatic; altered GI function; bowel rest indicated
MW, YH
Grade 2 ileus AE
CTCAE: E10813
an ileus AE that has severely altered GI function; TPN indicated
MW, YH
Grade 3 ileus AE
CTCAE: E10814
an infusion related reaction AE that has mild transient reaction; infusion interruption not indicated; intervention not indicated
MW, YH
Grade 1 infusion related reaction AE
CTCAE: E11128
an infusion related reaction AE where therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for less than or equal to 24 hrs
MW, YH
Grade 2 infusion related reaction AE
CTCAE: E11129
an infusion related reaction AE that is prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae
MW, YH
Grade 3 infusion related reaction AE
CTCAE: E11130
an infusion site extravasation AE that has erythema with associated symptoms (e.g., edema, pain, induration, phlebitis)
MW, YH
Grade 2 infusion site extravasation AE
CTCAE: E11134
an infusion site extravasation AE that has ulceration or necrosis; severe tissue damage; operative intervention indicated
MW, YH
Grade 3 infusion site extravasation AE
CTCAE: E11135
an irritability AE that has mild; easily consolable
MW, YH
Grade 1 irritability AE
CTCAE: E11145
an irritability AE that has moderate; limiting instrumental activities of daily living; increased attention indicated
MW, YH
Grade 2 irritability AE
CTCAE: E11146
an irritability AE that has severe abnormal or excessive response; limiting self care activities of daily living; inconsolable
MW, YH
Grade 3 irritability AE
CTCAE: E11147
a left ventricular dysfunction AE that has symptomatic due to drop in ejection fraction responsive to intervention
MW, YH
Grade 3 left venticular systolic dysfuction AE
CTCAE: E10131
a left ventricular dysfunction AE chracterized as refractory or poorly controlled heart failure due to drop in ejection fraction; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated
MW, YH
Grade 4 left ventricular systolic dysfuction AE
CTCAE: E10132
a lipase increased AE that is greater than the upper limit of normal - 1.5 times upper limit of normal
MW, YH
Grade 1 lipase increased AE
CTCAE: E12186
a lipase increased AE that is greater than 1.5 - 2.0 times upper limit of normal
MW, YH
Grade 2 lipase increased AE
CTCAE: E12187
a lipase increased AE that is greater than 2.0 - 5.0 times upper limit of normal
MW, YH
Grade 3 lipase increased AE
CTCAE: E12188
a lipase increased AE that is greater than 5.0 times upper limit of normal
MW, YH
Grade 4 lipase increased AE
CTCAE: E12189
a localized edema AE that has localized to dependent areas, no disability or functional impairment
MW, YH
Grade 1 localized edema AE
CTCAE: E11149
a lung infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 lung infection AE
CTCAE: E11445
a lung infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 lung infection AE
CTCAE: E11446
a lymphocyte count decreased AE that is less than the lower limit of normal - 800/mm3; less than the lower limit of normal - 0.8 x 10e9 /L
MW, YH
Grade 1 lymphocyte count decreased AE
CTCAE: E12191
a lymphocyte count decreased AE that is less than 800 - 500/mm3; less than 0.8 - 0.5 x 10e9 /L
MW, YH
Grade 2 lymphocyte count decreased AE
CTCAE: E12192
a lymphocyte count decreased AE that is less than 500 - 200/mm3; less than 0.5 - 0.2 x 10e9 /L
MW, YH
Grade 3 lymphocyte count decreased AE
CTCAE: E12193
a lymphocyte count decreased AE that is less than 200/mm3; less than 0.2 x 10e9 /L
MW, YH
Grade 4 lymphocyte count decreased AE
CTCAE: E12194
a myocarditis AE that has asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities
MW, YH
Grade 1 myocarditis AE
CTCAE: E10158
a myocarditis AE that has symptoms with mild to moderate activity or exertion
MW, YH
Grade 2 myocarditis AE
CTCAE: E10159
a myocarditis AE that has severe with symptoms at rest or with minimal activity or exertion; intervention indicated
MW, YH
Grade 3 myocarditis AE
CTCAE: E10160
a myocarditis AE that has life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support)
MW, YH
Grade 4 myocarditis AE
CTCAE: E10161
a neutrophil count decreased AE that is less than the lower limit of normal - 1500/mm3; less than the lower limit of normal - 1.5 x 10e9 /L
MW, YH
Grade 1 neutrophil count decreased AE
CTCAE: E12199
a neutrophil count decreased AE that is less than 1500 - 1000/mm3; less than 1.5 - 1.0 x 10e9 /L
MW, YH
Grade 2 neutrophil count decreased AE
CTCAE: E12200
a neutrophil count decreased AE that is less than 1000 - 500/mm3; less than 1.0 - 0.5 x 10e9 /L
MW, YH
Grade 3 neutrophil count decreased AE
CTCAE: E12201
a neutrophil count decreased AE that is less than 500/mm3; less than 0.5 x 10e9 /L
MW, YH
Grade 4 neutrophil count decreased AE
CTCAE: E12202
an esophageal stenosis AE that is symptomatic; altered GI function
MW, YH
Grade 2 esophageal stenosis AE
CTCAE: E10672
an esophageal stenosis AE that has severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 esophageal stenosis AE
CTCAE: E10673
an esophagitis AE that is symptomatic; altered eating/swallowing; oral supplements indicated
MW, YH
Grade 2 esophagitis AE
CTCAE: E10689
an esophagitis AE that has severely altered eating/swallowing; tube feeding, TPN or hospitalization indicated
MW, YH
Grade 3 esophagitis AE
CTCAE: E10690
an oral cavity fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 oral cavity fistula AE
CTCAE: E10890
an oral cavity fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 oral cavity fistula AE
CTCAE: E10891
a papilloedema AE that has a symptomatic decline in vision; visual field defect present sparing the central 20 degrees
MW, YH
Grade 2 papilledema AE
CTCAE: E10413
a papilloedema AE that has a marked visual field defect (worse than 20/40 but better than 20/200)
MW, YH
Grade 3 papilledema AE
CTCAE: E10414
a papilloedema AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 papilledema AE
CTCAE: E10415
a pericardial effusion AE that has asymptomatic effusion size small to moderate
MW, YH
Grade 2 pericardial effusion AE
CTCAE: E10173
a pericardial effusion AE that has effusion with physiologic consequences
MW, YH
Grade 3 pericardial effusion AE
CTCAE: E10174
a portal hypertension AE that has decreased portal vein flow
MW, YH
Grade 2 portal hypertension AE
CTCAE: E11239
a portal hypertension AE that has reversal/retrograde portal vein flow; associated with varices and/or ascites
MW, YH
Grade 3 portal hypertension AE
CTCAE: E11240
a dermatitis radiation AE that has faint erythema or dry desquamation
MW, YH
Grade 1 dermatitis radiation AE
CTCAE: E11676
a dermatitis radiation AE that has moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema
MW, YH
Grade 2 dermatitis radiation AE
CTCAE: E11677
a dermatitis radiation AE that has moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion
MW, YH
Grade 3 dermatitis radiation AE
CTCAE: E11678
a dermatitis radiation AE that has life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated
MW, YH
Grade 4 dermatitis radiation AE
CTCAE: E11679
a rectal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 rectal hemorrhage AE
CTCAE: E10958
a skin infection AE that is localized, local intervention indicated
MW, YH
Grade 1 skin infection AE
CTCAE: E11569
a skin infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 skin infection AE
CTCAE: E11570
a skin infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 skin infection AE
CTCAE: E11571
a small intestinal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living
MW, YH
Grade 2 small intestinal obstruction AE
CTCAE: E11023
a small intestinal stenosis AE that is symptomatic; altered GI function
MW, YH
Grade 2 small intestinal stenosis AE
CTCAE: E11034
a small intestinal stenosis AE that is symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated
MW, YH
Grade 3 small intestinal stenosis AE
CTCAE: E11035
a soft tissue infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 soft tissue infection AE
CTCAE: E11580
a soft tissue infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 soft tissue infection AE
CTCAE: E11581
a gastric hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 gastric hemorrhage AE
CTCAE: E10709
a tracheitis AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 tracheitis AE
CTCAE: E11600
a tracheitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 tracheitis AE
CTCAE: E11601
an upper gastrointestinal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 upper gastrointestinal hemorrhage AE
CTCAE: E11065
a urine output decreased AE that has oliguria (less than 80 ml in 8 hr)
MW, YH
Grade 3 urine output decreased AE
CTCAE: E12218
a urine output decreased AE that has anuria (less than 240 ml in 24 hr)
MW, YH
Grade 4 urine output decreased AE
CTCAE: E12219
a vaginal infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 vaginal infection AE
CTCAE: E11625
a vaginal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 vaginal infection AE
CTCAE: E11626
a venous injury AE that is symptomatic (e.g., claudication); repair or revision not indicated
MW, YH
Grade 2 venous injury AE
CTCAE: E12053
a venous injury AE that has severe symptoms; limiting self care activities of daily living; repair or revision indicated; disabling
MW, YH
Grade 3 venous injury AE
CTCAE: E12054
a venous injury AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated
MW, YH
Grade 4 venous injury AE
CTCAE: E12055
a weight increased AE that is 5 - less than 10% from baseline
MW, YH
Grade 1 weight increased AE
CTCAE: E12225
a weight increased AE that is 10 - less than 20% from baseline
MW, YH
Grade 2 weight increased AE
CTCAE: E12226
a weight increased AE that is greater than or equal to 20% from baseline
MW, YH
Grade 3 weight increased AE
CTCAE: E12227
a wolff-parkinson-white syndrome AE that is symptomatic and incompletely controlled medically or controlled with procedure
MW, YH
Grade 3 Wolff-Parkinson-White syndrom AE
CTCAE: E10247
a wound complication AE that has incisional separation of less than or equal to 25% of wound, no deeper than superficial fascia
MW, YH
Grade 1 wound complication AE
CTCAE: E12058
a wound complication AE that has incisional separation greater than 25% of wound; local care indicated
MW, YH
Grade 2 wound complication AE
CTCAE: E12059
a wound complication AE that has hernia without evidence of strangulation; fascial disruption/dehiscence; primary wound closure or revision by operative intervention indicated
MW, YH
Grade 3 wound complication AE
CTCAE: E12060
a wound complication AE that has hernia with evidence of strangulation; major reconstruction flap, grafting, resection, or amputation indicated
MW, YH
Grade 4 wound complication AE
CTCAE: E12061
a wound dehiscence AE that has incisional separation of less than or equal to 25% of wound, no deeper than superficial fascia
MW, YH
Grade 1 wound dehiscence AE
CTCAE: E12064
a wound dehiscence AE that has incisional separation greater than 25% of wound with local care; asymptomatic hernia or symptomatic hernia without evidence of strangulation
MW, YH
Grade 2 wound dehiscence AE
CTCAE: E12065
a wound dehiscence AE that has fascial disruption or dehiscence without evisceration; primary wound closure or revision by operative intervention indicated
MW, YH
Grade 3 wound dehiscence AE
CTCAE: E12066
a wound dehiscence AE that has life-threatening consequences; symptomatic hernia with evidence of strangulation; fascial disruption with evisceration; major reconstruction flap, grafting, resection, or amputation indicated
MW, YH
Grade 4 wound dehiscence AE
CTCAE: E12067
a multi-organ failure AE chracterized by shock with azotemia and acid-base disturbances; significant coagulation abnormalities
MW, YH
Grade 3 multi-organ failure AE
CTCAE: E11156
a multi-organ failure AE that has life-threatening consequences (e.g., vasopressor dependent and oliguric or anuric or ischemic colitis or lactic acidosis)
MW, YH
Grade 4 multi-organ failure AE
CTCAE: E11157
a restrictive cardiomyopathy AE that has symptomatic heart failure or other cardiac symptoms, responsive to intervention
MW, YH
Grade 3 restrictive cardiomyopathy AE
CTCAE: E10193
a restrictive cardiomyopathy AE that has refractory heart failure or other poorly controlled cardiac symptoms
MW, YH
Grade 4 restrictive cardiomyopathy AE
CTCAE: E10194
a complete atrioventricular block AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)
MW, YH
Grade 3 atrioventricular block complete AE
CTCAE: E10095
a Mobitz type I block AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)
MW, YH
Grade 3 Mobitz type I block AE
CTCAE: E10149
a Mobitz type II block AE that has symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker)
MW, YH
Grade 3 Mobitz type II atrioventricular block AE
CTCAE: E10143
a hemoglobin level increased AE where the increase is greater than 0 - 2 gm/dL above upper limit of normal or above baseline if baseline is above upper limit of normal
MW, YH
Grade 1 hemoglobin level increased AE
CTCAE: E12172
a hemoglobin level increased AE where the increase is greater than 2 - 4 gm/dL above the upper limit of normal or above baseline if baseline is above upper limit of normal
MW, YH
Grade 2 hemoglobin level increased AE
CTCAE: E12173
a hemoglobin level increased AE where the increase is greater than 4 gm/dL above the upper limit of normal or above baseline if baseline is above upper limit of normal
MW, YH
Grade 3 hemoglobin level increased AE
CTCAE: E12174
a right ventricular dysfunction AE that has asymptomatic with laboratory (e.g., BNP [B-Natriuretic Peptide ]) or cardiac imaging abnormalities
MW, YH
Grade 1 right ventricular dysfuction AE
CTCAE: E10197
a right ventricular dysfunction AE that has symptoms with mild to moderate activity or exertion
MW, YH
Grade 2 right ventricular dysfuction AE
CTCAE: E10198
a right ventricular dysfunction AE that has severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated
MW, YH
Grade 3 right ventricular dysfuction AE
CTCAE: E10199
a right ventricular dysfunction AE that has life-threatening consequences; urgent intervention indicated (e.g., ventricular assist device); heart transplant indicated
MW, YH
Grade 4 right ventricular dysfunction AE
CTCAE: E10200
a Intraoperative hemorrhage AE where postoperative radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 intraoperative hemorrhage AE
CTCAE: E11811
an uveitis AE that has anterior uveitis; medical intervention indicated
MW, YH
Grade 2 uveitis AE
CTCAE: E10444
an uveitis AE that has posterior or pan-uveitis
MW, YH
Grade 3 uveitis AE
CTCAE: E10445
an uveitis AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 uveitis AE
CTCAE: E10446
a retinopathy AE that is symptomatic with moderate decrease in visual acuity (20/40 or better); limiting instrumental activities of daily living
MW, YH
Grade 2 retinopathy AE
CTCAE: E10434
a retinopathy AE that is symptomatic with marked decrease in visual acuity (worse than 20/40); disabling; limiting self care activities of daily living
MW, YH
Grade 3 retinopathy AE
CTCAE: E10435
a retinopathy AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 retinopathy AE
CTCAE: E10436
a hearing loss AE for adults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of 15 - 25 dB averaged at 2 contiguous test frequencies in at least one ear. Adults not enrolled in Monitoring Program: subjective change in hearing in the absence of documented hearing loss. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift greater than20 dB at 8 kHz in at least one ear.
MW, YH
Grade 1 hearing loss AE
CTCAE: E10277
a hearing loss AE for adults enrolled in Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of greater than25 dB averaged at 2 contiguous test frequencies in at least one ear. Adults not enrolled in Monitoring Program: hearing loss but hearing aid or intervention not indicated; limiting instrumental activities of daily living. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift greater than20 dB at 4 kHz and above in at least one ear.
MW, YH
Grade 2 hearing loss AE
CTCAE: E10278
a hearing loss AE for adults enrolled in Monitoring Program (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): Threshold shift of greater than25 dB averaged at 3 contiguous test frequencies in at least one ear; therapeutic intervention indicated. Adults not enrolled in Monitoring Program: hearing loss with hearing aid or intervention indicated; limiting self care activities of daily living. Pediatric (on a 1, 2, 3, 4, 6 and 8 kHz audiogram): hearing loss sufficient to indicate therapeutic intervention, including hearing aids; threshold shift greater than20 dB at 3 kHz and above in at least one ear; additional speech-language related services indicated.
MW, YH
Grade 3 hearing loss AE
CTCAE: E10279
a hearing loss AE for adults: Decrease in hearing to profound bilateral loss (absolute threshold greater than80 dB HL at 2 kHz and above); non-servicable hearing. Pediatric: Audiologic indication for cochlear implant and additional speech-language related services indicated.
MW, YH
Grade 4 hearing loss AE
CTCAE: E10280
a international normalized ratio increased AE that is greater than 1 - 1.5 times the upper limit of normal; greater than 1 - 1.5 times above baseline if on anticoagulation
MW, YH
Grade 1 international normalized ratio increased AE
CTCAE: E12176
a international normalized ratio increased AE that is greater than 1.5 - 2.5 times the upper limit of normal; greater than 1.5 - 2.5 times above baseline if on anticoagulation
MW, YH
Grade 2 international normalized ratio increased AE
CTCAE: E12177
a international normalized ratio increased AE that is greater than 2.5 times the upper limit of normal; greater than 2.5 times above baseline if on anticoagulation
MW, YH
Grade 3 international normalized ratio increased AE
CTCAE: E12178
a fecal incontinence AE that has occasional use of pads required
MW, YH
Grade 1 fecal incontinence AE
CTCAE: E10694
a fecal incontinence AE that has daily use of pads required
MW, YH
Grade 2 fecal incontinence AE
CTCAE: E10695
a fecal incontinence AE that has severe symptoms; elective operative intervention indicated
MW, YH
Grade 3 fecal incontinence AE
CTCAE: E10696
a thrombotic thrombocytopenic purpura AE that has evidence of RBC destruction (schistocytosis) without clinical consequences
MW, YH
Grade 1 thrombotic thrombocytopenic purpura AE
CTCAE: E10062
a thrombotic thrombocytopenic purpura AE charaterized by laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae)
MW, YH
Grade 3 thrombotic thrombocytopenic purpura AE
CTCAE: E10063
a thrombotic thrombocytopenic purpura AE that has life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure)
MW, YH
Grade 4 thrombotic thrombocytopenic purpura AE
CTCAE: E10064
a glaucoma AE that has elevated intraocular pressure (EIOP) with single topical agent for intervention; no visual field deficit
MW, YH
Grade 1 glaucoma AE
CTCAE: E10393
a glaucoma AE that has elevated intraocular pressure causing early visual field deficits; multiple topical or oral agents indicated; limiting instrumental activities of daily living
MW, YH
Grade 2 glaucoma AE
CTCAE: E10394
a glaucoma AE that has elevated intraocular pressure causing marked visual field deficits (e.g., involving both superior and inferior visual fields); operative intervention indicated; limiting self care activities of daily living
MW, YH
Grade 3 glaucoma AE
CTCAE: E10395
a glaucoma AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 glaucoma AE
CTCAE: E10396
an anaphylaxis AE that has symptomatic bronchospasm, with or without urticaria; parenteral intervention indicated; allergy-related edema/angioedema; hypotension
MW, YH
Grade 3 anaphylaxis AE
CTCAE: E11255
a retinal detachment AE that has exudative and visual acuity 20/40 or better
MW, YH
Grade 2 retinal detachment AE
CTCAE: E10422
a retinal detachment AE that has rhegmatogenous or exudative detachment; operative intervention indicated; decline in vision (worse than 20/40 but better than 20/200)
MW, YH
Grade 3 retinal detachment AE
CTCAE: E10423
a retinal detachment AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 retinal detachment AE
CTCAE: E10424
a hemolysis AE that has laboratory evidence of hemolysis only (e.g., direct antiglobulin test; DAT; Coombs'; schistocytes; decreased haptoglobin)
MW, YH
Grade 1 hemolysis AE
CTCAE: E10038
a hemolysis AE that has evidence of hemolysis and greater than or equal to 2 gm decrease in hemoglobin.
MW, YH
Grade 2 hemolysis AE
CTCAE: E10039
a hemolysis AE where transfusion or medical intervention is indicated (e.g., steroids)
MW, YH
Grade 3 hemolysis AE
CTCAE: E10040
an anal fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 anal fistula AE
CTCAE: E10466
an anal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 anal fistula AE
CTCAE: E10467
an atrial tachycardia AE where IV medication is indicated
MW, YH
Grade 3 atrial tachycardia AE
CTCAE: E10169
an atrial tachycardia AE that has life-threatening consequences; incompletely controlled medically; cardioversion indicated
MW, YH
Grade 4 atrial tachycardia AE
CTCAE: E10170
a cholecystitis AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 cholecystitis AE
CTCAE: E11186
an autoimmune disorder AE that is asymptomatic; serologic or other evidence of autoimmune reaction, with normal organ function; intervention not indicated
MW, YH
Grade 1 autoimmune disorder AE
CTCAE: E11259
an autoimmune disorder AE that has evidence of autoimmune reaction involving a non-essential organ or function (e.g., hypothyroidism)
MW, YH
Grade 2 autoimmune disorder AE
CTCAE: E11260
an autoimmune disorder AE that has autoimmune reactions involving major organ (e.g., colitis, anemia, myocarditis, kidney)
MW, YH
Grade 3 autoimmune disorder AE
CTCAE: E11261
a spleen disorder AE that has incidental findings (e.g., Howell-Jolly bodies); mild degree of thrombocytosis and leukocytosis
MW, YH
Grade 1 spleen disorder AE
CTCAE: E10057
a spleen disorder AE when prophylactic antibiotics are indicated
MW, YH
Grade 2 spleen disorder AE
CTCAE: E10058
a burn AE that requires medical intervention; minimal debridement indicated
MW, YH
Grade 2 burn AE
CTCAE: E11671
a burn AE that requires moderate to major debridement or reconstruction indicated
MW, YH
Grade 3 burn AE
CTCAE: E11672
a papulopustular rash AE that has papules and/or pustules covering less than 10% body surface area which may or may not be associated with symptoms of pruritus or tenderness
MW, YH
Grade 1 papulopustular rash AE
CTCAE: E11492
a papulopustular rash AE that has papules and/or pustules covering 10-30% body surface area, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental activities of daily living
MW, YH
Grade 2 papulopustular rash AE
CTCAE: E11493
a papulopustular rash AE that has papules and/or pustules covering greater than 30% body surface area, which may or may not be associated with symptoms of pruritus or tenderness; limiting self-care activities of daily living; associated with local superinfection with oral antibiotics indicated
MW, YH
Grade 3 papulopustular rash AE
CTCAE: E11494
a papulopustular rash AE that has papules and/or pustules covering any % body surface area, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences
MW, YH
Grade 4 papulopustular rash AE
CTCAE: E11495
an acute coronary syndrome AE that has symptomatic, progressive angina; cardiac enzymes normal; hemodynamically stable
MW, YH
Grade 2 acute coronary syndrome AE
CTCAE: E10067
an acute coronary syndrome AE that has symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically stable
MW, YH
Grade 3 acute coronary syndrome AE
CTCAE: E10068
an acute coronary syndrome AE that has symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically unstable
MW, YH
Grade 4 acute coronary syndrome AE
CTCAE: E10069
an aortic valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging
MW, YH
Grade 1 aortic valve disease AE
CTCAE: E10072
an aortic valve disease AE that has symptomatic; moderate regurgitation or stenosis by imaging
MW, YH
Grade 2 aortic valve disease AE
CTCAE: E10073
an aortic valve disease AE that has symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention
MW, YH
Grade 3 aortic valve disease AE
CTCAE: E10074
an aortic valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)
MW, YH
Grade 4 aortic valve disease AE
CTCAE: E10075
an asystole AE that has periods of asystole; non-urgent medical management indicated
MW, YH
Grade 1 asystole AE
CTCAE: E10078
a constrictive pericarditis AE that has symptomatic heart failure or other cardiac symptoms, responsive to intervention
MW, YH
Grade 3 constrictive pericarditis AE
CTCAE: E10121
a constrictive pericarditis AE that has refractory heart failure or other poorly controlled cardiac symptoms
MW, YH
Grade 4 constrictive pericarditis AE
CTCAE: E10122
a mitral valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging
MW, YH
Grade 1 mitral valve disease AE
CTCAE: E10135
a mitral valve disease AE that has asymptomatic; moderate regurgitation or stenosis by imaging
MW, YH
Grade 2 mitral valve disease AE
CTCAE: E10136
a mitral valve disease AE that has symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention
MW, YH
Grade 3 mitral valve disease AE
CTCAE: E10137
a mitral valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)
MW, YH
Grade 4 mitral valve disease AE
CTCAE: E10138
a pulmonary valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging
MW, YH
Grade 1 pulmonary valve disease AE
CTCAE: E10187
a pulmonary valve disease AE that has asymptomatic; moderate regurgitation or stenosis by imaging
MW, YH
Grade 2 pulmonary valve disease AE
CTCAE: E10188
a pulmonary valve disease AE that has symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention
MW, YH
Grade 3 pulmonary valve disease AE
CTCAE: E10189
a pulmonary valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)
MW, YH
Grade 4 pulmonary valve disease AE
CTCAE: E10190
a tricuspid valve disease AE that has asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis
MW, YH
Grade 1 tricuspid valve disease AE
CTCAE: E10225
a tricuspid valve disease AE that is asymptomatic; moderate regurgitation or stenosis by imaging
MW, YH
Grade 2 tricuspid valve disease AE
CTCAE: E10226
a tricuspid valve disease AE that is symptomatic; severe regurgitation or stenosis; symptoms controlled with medical intervention
MW, YH
Grade 3 tricuspid valve disease AE
CTCAE: E10227
a tricuspid valve disease AE that has life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty)
MW, YH
Grade 4 tricuspid valve disease AE
CTCAE: E10228
an external ear inflammation AE that has external otitis with erythema or dry desquamation
MW, YH
Grade 1 external ear inflammation AE
CTCAE: E10267
an external ear inflammation AE that has external otitis with moist desquamation, edema, enhanced cerumen or discharge; tympanic membrane perforation; tympanostomy
MW, YH
Grade 2 external ear inflammation AE
CTCAE: E10268
an external ear inflammation AE that has external otitis with mastoiditis; stenosis or osteomyelitis; necrosis of soft tissue or bone
MW, YH
Grade 3 external ear inflammation AE
CTCAE: E10269
an external ear inflammation AE where urgent operative intervention indicated
MW, YH
Grade 4 external ear inflammation AE
CTCAE: E10270
a middle ear inflammation AE that has serous otitis
MW, YH
Grade 1 middle ear inflammation AE
CTCAE: E10282
a middle ear inflammation AE that has serous otitis, medical intervention indicated
MW, YH
Grade 2 middle ear inflammation AE
CTCAE: E10283
a middle ear inflammation AE that has mastoiditis; necrosis of canal soft tissue or bone
MW, YH
Grade 3 middle ear inflammation AE
CTCAE: E10284
a delayed puberty AE that has no breast development by age 13 yrs for females; testes volume of <3 cc or no Tanner Stage 2 development by age 14.5 yrs for males
MW, YH
Grade 2 delayed puberty AE
CTCAE: E10309
a delayed puberty AE that has no breast development by age 14 yrs for females; no increase in testes volume or no Tanner Stage 2 by age 16 yrs for males; hormone replacement indicated
MW, YH
Grade 3 delayed puberty AE
CTCAE: E10310
a growth accelerated AE that has greater than or equal to +2 SD (standard deviation) above mid parental height or target height
MW, YH
Grade 2 growth accelerated AE
CTCAE: E10318
a precocious puberty AE that has physical signs of puberty with no biochemical markers for females younger than 8 years and males younger than 9 years
MW, YH
Grade 1 precocious puberty AE
CTCAE: E10341
a precocious puberty AE that has physical signs and biochemical markers of puberty for females younger than 8 years and males younger than 9 years
MW, YH
Grade 2 precocious puberty AE
CTCAE: E10342
a corneal ulcer AE that has limiting self care activities of daily living declining vision (worse than 20/40 but better than 20/200)
MW, YH
Grade 3 corneal ulcer AE
CTCAE: E10361
a corneal ulcer AE that has perforation or blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 corneal ulcer AE
CTCAE: E10362
a dry eye AE that is asymptomatic; clinical or diagnostic observations only; mild symptoms relieved by lubricants
MW, YH
Grade 1 dry eye AE
CTCAE: E10364
a dry eye AE that has a decrease in visual acuity (<20/40); limiting self care activities of daily living
MW, YH
Grade 3 dry eye AE
CTCAE: E10366
a keratitis AE that has a decline in vision (worse than 20/40 but better than 20/200); limiting self care activities of daily living
MW, YH
Grade 3 keratitis AE
CTCAE: E10399
a keratitis AE that has perforation or blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 keratitis AE
CTCAE: E10400
a night blindness AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 night blindness AE
CTCAE: E10405
an optic nerve disorder AE that has limiting vision of the affected eye (20/40 or better)
MW, YH
Grade 2 optic nerve disorder AE
CTCAE: E10408
an optic nerve disorder AE that has limiting vision in the affected eye (worse than 20/40 but better than 20/200)
MW, YH
Grade 3 optic nerve disorder AE
CTCAE: E10409
an optic nerve disorder AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 optic nerve disorder AE
CTCAE: E10410
a retinal tear AE where laser therapy or pneumopexy indicated
MW, YH
Grade 2 retinal tear AE
CTCAE: E10426
a retinal tear AE where vitroretinal surgical repair indicated
MW, YH
Grade 3 retinal tear AE
CTCAE: E10427
a retinal tear AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 retinal tear AE
CTCAE: E10428
a retinal vascular disorder AE where topical medication indicated
MW, YH
Grade 2 retinal vascular disorder AE
CTCAE: E10430
a retinal vascular disorder AE where intravitreal medication; operative intervention indicated
MW, YH
Grade 3 retinal vascular disorder AE
CTCAE: E10431
a scleral disorder AE that is symptomatic, limiting instrumental activities of daily living; moderate decrease in visual acuity (20/40 or better)
MW, YH
Grade 2 scleral disorder AE
CTCAE: E10439
a scleral disorder AE that is symptomatic, limiting self care activities of daily living; marked decrease in visual acuity (worse than 20/40)
MW, YH
Grade 3 scleral disorder AE
CTCAE: E10440
a scleral disorder AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 scleral disorder AE
CTCAE: E10441
a vitreous hemorrhage AE that has limiting self care activities of daily living; vitrectomy indicated
MW, YH
Grade 3 vitreous hemorrhage AE
CTCAE: E10450
a vitreous hemorrhage AE that has blindness (20/200 or worse) in the affected eye
MW, YH
Grade 4 vitreous hemorrhage AE
CTCAE: E10451
an anal necrosis AE where TPN or hospitalization indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 anal necrosis AE
CTCAE: E10483
an anal stenosis AE that is symptomatic; altered GI function
MW, YH
Grade 2 anal stenosis AE
CTCAE: E10492
an anal stenosis AE that is symptomatic and severely altered GI function; non-emergent operative intervention indicated; TPN or hospitalization indicated
MW, YH
Grade 3 anal stenosis AE
CTCAE: E10493
a bloating AE that has no change in bowel function or oral intake
MW, YH
Grade 1 bloating AE
CTCAE: E10509
a bloating AE that is symptomatic, decreased oral intake; change in bowel function
MW, YH
Grade 2 bloating AE
CTCAE: E10510
a cecal hemorrhage AE that has moderate symptoms; medical intervention or minor cauterization indicated
MW, YH
Grade 2 cecal hemorrhage AE
CTCAE: E10513
a cecal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 cecal hemorrhage AE
CTCAE: E10514
a colonic fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 colonic fistula AE
CTCAE: E10529
a colonic fistula AE that has severely altered GI function; bowel rest, TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 colonic fistula AE
CTCAE: E10530
a colonic hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 colonic hemorrhage AE
CTCAE: E10536
a colonic obstruction AE that is symptomatic; altered GI function
MW, YH
Grade 2 colonic obstruction AE
CTCAE: E10541
a colonic ulcer AE that is symptomatic; altered GI function
MW, YH
Grade 2 colonic ulcer AE
CTCAE: E10558
a colonic ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling
MW, YH
Grade 3 colonic ulcer AE
CTCAE: E10559
a duodenal fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 duodenal fistula AE
CTCAE: E10584
a duodenal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 duodenal fistula AE
CTCAE: E10585
a duodenal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 duodenal hemorrhage AE
CTCAE: E10591
a duodenal obstruction AE that is symptomatic; altered GI function
MW, YH
Grade 2 duodenal obstruction AE
CTCAE: E10596
a duodenal stenosis AE that is symptomatic; altered GI function
MW, YH
Grade 2 duodenal stenosis AE
CTCAE: E10607
a duodenal stenosis AE that has severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 duodenal stenosis AE
CTCAE: E10608
an esophageal fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 esophageal fistula AE
CTCAE: E10641
an esophageal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 esophageal fistula AE
CTCAE: E10642
an esophageal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 esophageal hemorrhage AE
CTCAE: E10648
an esophageal necrosis AE that has inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 esophageal necrosis AE
CTCAE: E10652
an esophageal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living
MW, YH
Grade 2 esophageal obstruction AE
CTCAE: E10657
an esophageal ulcer AE that is symptomatic; altered GI function; limiting instrumental activities of daily living
MW, YH
Grade 2 esophageal ulcer AE
CTCAE: E10678
an esophageal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care activities of daily living; disabling
MW, YH
Grade 3 esophageal ulcer AE
CTCAE: E10679
an esophageal varices hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 esophageal varices hemorrhage AE
CTCAE: E10684
a gastric fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 gastric fistula AE
CTCAE: E10702
a gastric fistula AE that has severely altered GI function; bowel rest; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 gastric fistula AE
CTCAE: E10703
a gastric necrosis AE that has inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 gastric necrosis AE
CTCAE: E10713
a gastric stenosis AE that is symptomatic; altered GI function
MW, YH
Grade 2 gastric stenosis AE
CTCAE: E10723
a gastric stenosis AE that has severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 gastric stenosis AE
CTCAE: E10724
a gastrointestinal fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 gastrointestinal fistula AE
CTCAE: E10751
a gastrointestinal fistula AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated
MW, YH
Grade 3 gastrointestinal fistula AE
CTCAE: E10752
a gastroparesis AE that has mild nausea, early satiety and bloating, able to maintain caloric intake on regular diet
MW, YH
Grade 1 gastroparesis AE
CTCAE: E10760
a gastroparesis AE that has moderate symptoms; able to maintain nutrition with dietary and lifestyle modifications; may need pharmacologic intervention
MW, YH
Grade 2 gastroparesis AE
CTCAE: E10761
a gastroparesis AE that has weight loss; refractory to medical intervention; unable to maintain nutrition orally
MW, YH
Grade 3 gastroparesis AE
CTCAE: E10762
an ileal fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 ileal fistula AE
CTCAE: E10779
an ileal fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 ileal fistula AE
CTCAE: E10780
an ileal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 ileal hemorrhage AE
CTCAE: E10786
an ileal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living
MW, YH
Grade 2 ileal obstruction AE
CTCAE: E10791
an ileal stenosis AE that is symptomatic; altered GI function
MW, YH
Grade 2 ileal stenosis AE
CTCAE: E10802
an ileal stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 ileal stenosis AE
CTCAE: E10803
an ileal ulcer AE that is symptomatic; altered GI function
MW, YH
Grade 2 ileal ulcer AE
CTCAE: E10808
an ileal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling
MW, YH
Grade 3 ileal ulcer AE
CTCAE: E10809
an intra-abdominal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 intra-abdominal hemorrhage AE
CTCAE: E10819
a jejunal fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 jejunal fistula AE
CTCAE: E10824
a jejunal fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 jejunal fistula AE
CTCAE: E10825
ajejunal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 jejunal hemorrhage AE
CTCAE: E10831
a jejunal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living
MW, YH
Grade 2 jejunal obstruction AE
CTCAE: E10836
a jejunal stenosis AE that is symptomatic; altered GI function
MW, YH
Grade 2 jejunal stenosis AE
CTCAE: E10847
a jejunal stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 jejunal stenosis AE
CTCAE: E10848
a jejunal ulcer AE that is symptomatic; altered GI function
MW, YH
Grade 2 jejunal ulcer AE
CTCAE: E10853
a jejunal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling
MW, YH
Grade 3 jejunal ulcer AE
CTCAE: E10854
a lower gastrointestinal hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 lower gastrointestinal hemorrhage AE
CTCAE: E10864
a malabsorption AE where altered diet; oral intervention indicated
MW, YH
Grade 2 malabsorption AE
CTCAE: E10868
a malabsorption AE that has inability to aliment adequately; TPN indicated
MW, YH
Grade 3 malabsorption AE
CTCAE: E10869
an obstruction gastric AE that is symptomatic; altered GI function; limiting instrumental activities of daily living
MW, YH
Grade 2 obstruction gastric AE
CTCAE: E10884
an oral hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 oral hemorrhage AE
CTCAE: E10901
a pancreatic duct stenosis AE that is symptomatic; altered GI function
MW, YH
Grade 2 pancreatic duct stenosis AE
CTCAE: E10910
a pancreatic duct stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 pancreatic duct stenosis AE
CTCAE: E10911
a pancreatic fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 pancreatic fistula AE
CTCAE: E10916
a pancreatic fistula AE that has severely altered GI function; tube feeding or TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 pancreatic fistula AE
CTCAE: E10917
a pancreatic hemorrhage AE where transfusion, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 pancreatic hemorrhage AE
CTCAE: E10923
a pancreatic necrosis AE where tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 pancreatic necrosis AE
CTCAE: E10927
a peritoneal necrosis AE where tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 peritoneal necrosis AE
CTCAE: E10940
a proctitis AE that has rectal discomfort, intervention not indicated
MW, YH
Grade 1 proctitis AE
CTCAE: E10944
a proctitis AE that has symptoms (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental activities of daily living
MW, YH
Grade 2 proctitis AE
CTCAE: E10945
a proctitis AE that has severe symptoms; fecal urgency or stool incontinence; limiting self care activities of daily living
MW, YH
Grade 3 proctitis AE
CTCAE: E10946
a rectal fistula AE that is symptomatic; altered GI function
MW, YH
Grade 2 rectal fistula AE
CTCAE: E10951
a rectal fistula AE that has severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 rectal fistula AE
CTCAE: E10952
a rectal obstruction AE that is symptomatic; altered GI function; limiting instrumental activities of daily living
MW, YH
Grade 2 rectal obstruction AE
CTCAE: E10973
a rectal stenosis AE that is symptomatic; altered GI function
MW, YH
Grade 2 rectal stenosis AE
CTCAE: E10988
a rectal stenosis AE that has severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 rectal stenosis AE
CTCAE: E10989
a rectal ulcer AE that is symptomatic; altered GI function (e.g. altered dietary habits, vomiting, diarrhea)
MW, YH
Grade 2 rectal ulcer AE
CTCAE: E10994
a rectal ulcer AE that has severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling
MW, YH
Grade 3 rectal ulcer AE
CTCAE: E10995
a retroperitoneal hemorrhage AE where transfusion, medical, radiologic, endoscopic, or elective operative intervention indicated
MW, YH
Grade 3 retroperitoneal hemorrhage AE
CTCAE: E11000
a salivary gland fistula AE that is symptomatic; altered GI function; tube feeding indicated
MW, YH
Grade 2 salivary gland fistula AE
CTCAE: E11011
a salivary gland fistula AE that has severely altered GI function; hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 salivary gland fistula AE
CTCAE: E11012
a tooth discoloration AE that has surface stains
MW, YH
Grade 1 tooth discoloration AE
CTCAE: E11053
an edema limbs AE that has 5 - 10% inter-limb discrepancy in volume or circumference at point of greatest visible difference; swelling or obscuration of anatomic architecture on close inspection
MW, YH
Grade 1 edema limbs AE
CTCAE: E11087
an edema limbs AE that has more than 10 to 30% inter-limb discrepancy in volume or circumference at point of greatest visible difference; readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental activities of daily living
MW, YH
Grade 2 edema limbs AE
CTCAE: E11088
an edema limbs AE that has more than 30% inter-limb discrepancy in volume; gross deviation from normal anatomic contour; limiting self care activities of daily living
MW, YH
Grade 3 edema limbs AE
CTCAE: E11089
an edema trunk AE that has swelling or obscuration of anatomic architecture on close inspection
MW, YH
Grade 1 edema trunk AE
CTCAE: E11091
an edema trunk AE that has readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour; limiting instrumental activities of daily living
MW, YH
Grade 2 edema trunk AE
CTCAE: E11092
an edema trunk AE that has gross deviation from normal anatomic contour; limiting self care activities of daily living
MW, YH
Grade 3 edema trunk AE
CTCAE: E11093
A neck edema AE that has moderate neck edema; slight obliteration of anatomic landmarks; limiting instrumental activities of daily living
MW, YH
Grade 2 neck edema AE
CTCAE: E11161
a neck edema AE that has generalized neck edema (e.g., difficulty in turning neck); limiting self care activities of daily living
MW, YH
Grade 3 neck edema AE
CTCAE: E11162
a bile duct stenosis AE that is symptomatic; altered GI function; IV fluids indicated <24 hrs
MW, YH
Grade 2 bile duct stenosis AE
CTCAE: E11175
a bile duct stenosis AE that has severely altered GI function; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 bile duct stenosis AE
CTCAE: E11176
a biliary fistula AE that has severely altered GI function; TPN indicated; endoscopic intervention indicated; elective operative intervention indicated
MW, YH
Grade 3 biliary fistula AE
CTCAE: E11181
a gallbladder fistula AE that is symptomatic or severely altered GI function; TPN indicated; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 gallbladder fistula AE
CTCAE: E11192
a gallbladder obstruction AE that is symptomatic; altered GI function; IV fluids indicated <24 hrs
MW, YH
Grade 2 gallbladder obstruction AE
CTCAE: E11200
a gallbladder obstruction AE that is symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated
MW, YH
Grade 3 gallbladder obstruction AE
CTCAE: E11201
a hepatic hemorrhage AE where transfusion indicated
MW, YH
Grade 3 hepatic hemorrhage AE
CTCAE: E11218
a perforation bile duct AE where radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 perforation bile duct AE
CTCAE: E11235
an abdominal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 abdominal infection AE
CTCAE: E11283
an anorectal infection AE that is localized; local intervention indicated
MW, YH
Grade 1 anorectal infection AE
CTCAE: E11287
an anorectal infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 anorectal infection AE
CTCAE: E11288
an anorectal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 anorectal infection AE
CTCAE: E11289
an appendicitis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 appendicitis AE
CTCAE: E11293
an arteritis infective AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 arteritis infective AE
CTCAE: E11302
a biliary tract infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 biliary tract infection AE
CTCAE: E11306
a bladder infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 bladder infection AE
CTCAE: E11310
a bladder infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 bladder infection AE
CTCAE: E11311
a bone infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 bone infection AE
CTCAE: E11315
a bronchial infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 bronchial infection AE
CTCAE: E11324
a bronchial infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 bronchial infection AE
CTCAE: E11325
a cecal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 cecal infection AE
CTCAE: E11334
a cervicitis infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 cervicitis infection AE
CTCAE: E11338
a cervicitis infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 cervicitis infection AE
CTCAE: E11339
a conjunctivitis infective AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 conjunctivitis infective AE
CTCAE: E11343
a conjunctivitis infective AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 conjunctivitis infective AE
CTCAE: E11344
a corneal infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 corneal infection AE
CTCAE: E11348
a corneal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 corneal infection AE
CTCAE: E11349
a cranial nerve infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 cranial nerve infection AE
CTCAE: E11353
a duodenal infection AE that has moderate symptoms; medical intervention indicated (e.g., oral antibiotics)
MW, YH
Grade 2 duodenal infection AE
CTCAE: E11361
a duodenal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 duodenal infection AE
CTCAE: E11362
an encephalitis infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; severe changes in mental status; self-limited seizure activity; focal neurologic abnormalities
MW, YH
Grade 3 encephalitis infection AE
CTCAE: E11366
an encephalomyelitis infection AE when IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 encephalomyelitis infection AE
CTCAE: E11370
an endocarditis infective AE when IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 endocarditis infective AE
CTCAE: E11374
an endophthalmitis AE that has blindness (20/200 or worse)
MW, YH
Grade 4 endophthalmitis AE
CTCAE: E11380
an enterocolitis infectious AE that has the passage of more than 3 unformed stools per 24 hrs or duration of illness longer than 48 hrs; moderate abdominal pain
MW, YH
Grade 2 enterocolitis infectious AE
CTCAE: E11382
an enterocolitis infectious AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated; profuse watery diarrhea with signs of hypovolemia; bloody diarrhea; fever; severe abdominal pain; hospitalization indicated
MW, YH
Grade 3 enterocolitis infectious AE
CTCAE: E11383
an esophageal infection AE where local intervention indicated (e.g., oral antibiotic, antifungal, antiviral)
MW, YH
Grade 2 esophageal infection AE
CTCAE: E11387
an esophageal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 esophageal infection AE
CTCAE: E11388
an eye infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 eye infection AE
CTCAE: E11392
an eye infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 eye infection AE
CTCAE: E11393
an eye infection AE that has life-threatening consequences; urgent intervention indicated; enucleation
MW, YH
Grade 4 eye infection AE
CTCAE: E11394
a gallbladder infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 gallbladder infection AE
CTCAE: E11397
a gum infection AE where local therapy indicated (swish and swallow)
MW, YH
Grade 1 gum infection AE
CTCAE: E11401
a gum infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 gum infection AE
CTCAE: E11402
a gum infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 gum infection AE
CTCAE: E11403
a hepatic infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 hepatic infection AE
CTCAE: E11407
a infective myositis AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 infective myositis AE
CTCAE: E11422
a infective myositis AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 infective myositis AE
CTCAE: E11423
a joint infection AE that is localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); needle aspiration indicated (single or multiple)
MW, YH
Grade 2 joint infection AE
CTCAE: E11427
a joint infection AE where arthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage)
MW, YH
Grade 3 joint infection AE
CTCAE: E11428
a kidney infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 kidney infection AE
CTCAE: E11432
a lip infection AE that is localized, local intervention indicated
MW, YH
Grade 1 lip infection AE
CTCAE: E11441
a lip infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 lip infection AE
CTCAE: E11442
a lip infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 lip infection AE
CTCAE: E11443
a lymph gland infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 lymph gland infection AE
CTCAE: E11450
a lymph gland infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 lymph gland infection AE
CTCAE: E11451
a mediastinal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 mediastinal infection AE
CTCAE: E11455
a mucosal infection AE that is localized, local intervention indicated
MW, YH
Grade 1 mucosal infection AE
CTCAE: E11463
a mucosal infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 mucosal infection AE
CTCAE: E11464
a mucosal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 mucosal infection AE
CTCAE: E11465
a nail infection AE that is localized, local intervention indicated
MW, YH
Grade 1 nail infection AE
CTCAE: E11469
a nail infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 nail infection AE
CTCAE: E11470
a nail infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 nail infection AE
CTCAE: E11471
an otitis externa AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 otitis externa AE
CTCAE: E11473
an otitis externa AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 otitis externa AE
CTCAE: E11474
an ovarian infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 ovarian infection AE
CTCAE: E11483
an ovarian infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 ovarian infection AE
CTCAE: E11484
a pancreas infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 pancreas infection AE
CTCAE: E11488
a paronychia AE that has nail fold edema or erythema; disruption of the cuticle
MW, YH
Grade 1 paronychia AE
CTCAE: E11498
a paronychia AE where localized intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); nail fold edema or erythema with pain; associated with discharge or nail plate separation; limiting instrumental activities of daily living
MW, YH
Grade 2 paronychia AE
CTCAE: E11499
a paronychia AE where surgical intervention or IV antibiotics indicated; limiting self care activities of daily living
MW, YH
Grade 3 paronychia AE
CTCAE: E11500
a pelvic infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 pelvic infection AE
CTCAE: E11502
a pelvic infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 pelvic infection AE
CTCAE: E11503
a penile infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 penile infection AE
CTCAE: E11507
a penile infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 penile infection AE
CTCAE: E11508
a periorbital infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 periorbital infection AE
CTCAE: E11512
a periorbital infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 periorbital infection AE
CTCAE: E11513
a peripheral nerve infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 peripheral nerve infection AE
CTCAE: E11517
a peripheral nerve infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 peripheral nerve infection AE
CTCAE: E11518
a peritoneal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 peritoneal infection AE
CTCAE: E11522
a phlebitis infective AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 phlebitis infective AE
CTCAE: E11531
a phlebitis infective AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 phlebitis infective AE
CTCAE: E11532
a pleural infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 pleural infection AE
CTCAE: E11536
a pleural infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 pleural infection AE
CTCAE: E11537
a prostate infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 prostate infection AE
CTCAE: E11541
a prostate infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 prostate infection AE
CTCAE: E11542
a rhinitis infective AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 rhinitis infective AE
CTCAE: E11549
a salivary gland infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 salivary gland infection AE
CTCAE: E11551
a salivary gland infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 salivary gland infection AE
CTCAE: E11552
a scrotal infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 scrotal infection AE
CTCAE: E11556
a scrotal infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 scrotal infection AE
CTCAE: E11557
a small intestine infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 small intestine infection AE
CTCAE: E11575
a small intestine infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 small intestine infection AE
CTCAE: E11576
a splenic infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 splenic infection AE
CTCAE: E11585
a stoma site infection AE that is localized, local intervention indicated
MW, YH
Grade 1 stoma site infection AE
CTCAE: E11589
a stoma site infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 stoma site infection AE
CTCAE: E11590
a stoma site infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 stoma site infection AE
CTCAE: E11591
a tooth infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 tooth infection AE
CTCAE: E11595
a tooth infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 tooth infection AE
CTCAE: E11596
an upper respiratory infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 upper respiratory infection AE
CTCAE: E11605
an upper respiratory infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 upper respiratory infection AE
CTCAE: E11606
a urethral infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 urethral infection AE
CTCAE: E11610
a urethral infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 urethral infection AE
CTCAE: E11611
a uterine infection AE that has moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 uterine infection AE
CTCAE: E11620
a uterine infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 uterine infection AE
CTCAE: E11621
a vulval infection AE that is localized, local intervention indicated
MW, YH
Grade 1 vulval infection AE
CTCAE: E11630
A vulval infection AE where oral intervention indicated (e.g., antibiotic, antifungal, antiviral)
MW, YH
Grade 2 vulval infection AE
CTCAE: E11631
a vulval infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 vulval infection AE
CTCAE: E11632
a wound infection AE that is localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
MW, YH
Grade 2 wound infection AE
CTCAE: E11636
a wound infection AE where IV antibiotic, antifungal, or antiviral intervention indicated; radiologic or operative intervention indicated
MW, YH
Grade 3 wound infection AE
CTCAE: E11637
an ankle fracture AE that is mild; non-surgical intervention indicated
MW, YH
Grade 1 ankle fracture AE
CTCAE: E11641
an ankle fracture AE that is limiting instrumental activities of daily living; operative intervention indicated
MW, YH
Grade 2 ankle fracture AE
CTCAE: E11642
an ankle fracture AE that is limiting self care activities of daily living; elective surgery indicated
MW, YH
Grade 3 ankle fracture AE
CTCAE: E11643
an aortic injury AE that has severe symptoms; limiting self care activities of daily living; disabling; repair or revision indicated
MW, YH
Grade 3 aortic injury AE
CTCAE: E11645
an aortic injury AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated
MW, YH
Grade 4 aortic injury AE
CTCAE: E11646
an arterial injury AE that is symptomatic (e.g., claudication); repair or revision not indicated
MW, YH
Grade 2 arterial injury AE
CTCAE: E11650
an arterial injury AE that has severe symptoms; limiting self care activities of daily living; disabling; repair or revision indicated
MW, YH
Grade 3 arterial injury AE
CTCAE: E11651
an arterial injury AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated
MW, YH
Grade 4 arterial injury AE
CTCAE: E11652
a biliary anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 biliary anastomotic leak AE
CTCAE: E11657
a bladder anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 bladder anastomotic leak AE
CTCAE: E11663
an esophageal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 esophageal anastomotic leak AE
CTCAE: E11684
a fallopian tube anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 fallopian tube anastomotic leak AE
CTCAE: E11694
a fallopian tube perforation AE that has life-threatening consequences; urgent operative intervention indicated (e.g., organ resection)
MW, YH
Grade 4 fallopian tube perforation AE
CTCAE: E11701
a gastric anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 gastric anastomotic leak AE
CTCAE: E11712
a gastrointestinal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 gastrointestinal anastomotic leak
CTCAE: E11718
a gastrointestinal stoma necrosis AE that is a superficial necrosis; intervention not indicated
MW, YH
Grade 2 gastrointestinal stoma necrosis
CTCAE: E11722
a hip fracture AE that has a hairline fracture; mild pain; limiting instrumental activities of daily living; non-surgical intervention indicated
MW, YH
Grade 2 hip fracture AE
CTCAE: E11727
a hip fracture AE that has severe pain; hospitalization or intervention indicated for pain control (e.g., traction); operative intervention indicated
MW, YH
Grade 3 hip fracture AE
CTCAE: E11728
a hip fracture AE that has life-threatening consequences; symptoms associated with neurovascular compromise
MW, YH
Grade 4 hip fracture AE
CTCAE: E11729
an injury to carotid artery AE that has severe symptoms; limiting self care activities of daily living (e.g., transient cerebral ischemia); repair or revision indicated
MW, YH
Grade 3 injury to carotid artery AE
CTCAE: E11731
an injury to jugular vein AE that is symptomatic limiting self care activities of daily living; disabling; repair or revision indicated
MW, YH
Grade 3 injury to jugular vein AE
CTCAE: E11738
an injury to superior vena cava AE that has severe symptoms; limiting self care activities of daily living; disabling; repair or revision indicated
MW, YH
Grade 3 injury to superior vena cava AE
CTCAE: E11744
a injury to superior vena cava AE that has life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated
MW, YH
Grade 4 injury to superior vena cava AE
CTCAE: E11745
an intestinal stoma leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 intestinal stoma leak AE
CTCAE: E11756
an intestinal stoma leak AE that has severe symptoms; IV fluids, tube feeding, or TPN indicated greater than or equal to 24 hrs; elective operative intervention indicated
MW, YH
Grade 3 intestinal stoma leak AE
CTCAE: E11761
an intestinal stoma site bleeding AE that has minimal bleeding identified on clinical exam; intervention not indicated
MW, YH
Grade 1 intestinal stoma site bleeding AE
CTCAE: E11765
an intestinal stoma site bleeding AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated
MW, YH
Grade 3 intestinal stoma site bleeding AE
CTCAE: E11767
an intraoperative arterial injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative arterial injury AE
CTCAE: E11771
an intraoperative arterial injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative arterial injury AE
CTCAE: E11772
an intraoperative arterial injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative arterial injury AE
CTCAE: E11773
an intraoperative breast injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative breast injury AE
CTCAE: E11777
an intraoperative breast injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative breast injury AE
CTCAE: E11778
an intraoperative breast injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative breast injury AE
CTCAE: E11779
an intraoperative cardiac injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 3 intraoperative cardiac injury AE
CTCAE: E11783
an intraoperative ear injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative ear injury AE
CTCAE: E11787
an intraoperative ear injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative ear injury AE
CTCAE: E11788
an intraoperative ear injury AE where complete resection of injured organ/structure indicated; disabling (e.g., impaired hearing; impaired balance)
MW, YH
Grade 3 intraoperative ear injury AE
CTCAE: E11789
an intraoperative endocrine injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative endocrine injury AE
CTCAE: E11793
an intraoperative endocrine injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative endocrine injury AE
CTCAE: E11794
an intraoperative endocrine injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative endocrine injury AE
CTCAE: E11795
an intraoperative gastrointestinal injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative gastrointestinal injury AE
CTCAE: E11799
an intraoperative gastrointestinal injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative gastrointestinal injury AE
CTCAE: E11800
an intraoperative gastrointestinal injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative gastrointestinal injury AE
CTCAE: E11801
a lintraoperative head and neck injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 lintraoperative head and neck injury AE
CTCAE: E11805
a lintraoperative head and neck injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 lintraoperative head and neck injury AE
CTCAE: E11806
a lintraoperative head and neck injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 lintraoperative head and neck injury AE
CTCAE: E11807
an intraoperative hepatobiliary injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative hepatobiliary injury AE
CTCAE: E11815
an intraoperative hepatobiliary injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative hepatobiliary injury AE
CTCAE: E11816
an intraoperative hepatobiliary injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative hepatobiliary injury AE
CTCAE: E11817
an intraoperative musculoskeletal injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative musculoskeletal injury AE
CTCAE: E11821
an intraoperative musculoskeletal injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative musculoskeletal injury AE
CTCAE: E11822
an intraoperative musculoskeletal injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative musculoskeletal injury AE
CTCAE: E11823
an intraoperative neurological injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative neurological injury AE
CTCAE: E11827
an intraoperative neurological injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative neurological injury AE
CTCAE: E11828
an intraoperative neurological injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative neurological injury AE
CTCAE: E11829
an intraoperative ocular injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative ocular injury AE
CTCAE: E11833
an intraoperative ocular injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative ocular injury AE
CTCAE: E11834
an intraoperative ocular injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative ocular injury AE
CTCAE: E11835
an intraoperative renal injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative renal injury AE
CTCAE: E11839
an intraoperative renal injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative renal injury AE
CTCAE: E11840
an intraoperative renal injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative renal injury AE
CTCAE: E11841
an intraoperative reproductive tract injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative reproductive tract injury AE
CTCAE: E11845
an intraoperative reproductive tract injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative reproductive tract injury AE
CTCAE: E11846
an intraoperative reproductive tract injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative reproductive tract injury AE
CTCAE: E11847
an intraoperative respiratory injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative respiratory injury AE
CTCAE: E11851
an intraoperative respiratory injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative respiratory injury AE
CTCAE: E11852
an intraoperative respiratory injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative respiratory injury AE
CTCAE: E11853
an intraoperative skin injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative skin injury AE
CTCAE: E11857
an intraoperative skin injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative skin injury AE
CTCAE: E11858
an intraoperative skin injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative skin injury AE
CTCAE: E11859
an intraoperative splenic injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 2 intraoperative splenic injury AE
CTCAE: E11863
an intraoperative splenic injury AE where resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative splenic injury AE
CTCAE: E11864
an intraoperative urinary injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative urinary injury AE
CTCAE: E11868
an intraoperative urinary injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative urinary injury AE
CTCAE: E11869
an intraoperative urinary injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative urinary injury AE
CTCAE: E11870
an intraoperative venous injury AE where primary repair of injured organ/structure indicated
MW, YH
Grade 1 intraoperative venous injury AE
CTCAE: E11874
an intraoperative venous injury AE where partial resection of injured organ/structure indicated
MW, YH
Grade 2 intraoperative venous injury AE
CTCAE: E11875
an intraoperative venous injury AE where complete resection or reconstruction of injured organ/structure indicated; disabling
MW, YH
Grade 3 intraoperative venous injury AE
CTCAE: E11876
a kidney anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 kidney anastomotic leak AE
CTCAE: E11882
a large intestinal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 large intestinal anastomotic leak AE
CTCAE: E11888
a pancreatic anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 pancreatic anastomotic leak AE
CTCAE: E11894
a pharyngeal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 pharyngeal anastomotic leak AE
CTCAE: E11900
a postoperative hemorrhage AE that has moderate bleeding; radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 2 postoperative hemorrhage AE
CTCAE: E11905
a postoperative hemorrhage AE where transfusion indicated of greather than or equal to 2 units (10 cc/kg for pediatrics) pRBCs beyond protocol specification; urgent radiologic, endoscopic, or operative intervention indicated
MW, YH
Grade 3 postoperative hemorrhage AE
CTCAE: E11906
a postoperative thoracic procedure complication AE when the patient is extubated within 24 - 72 hrs postoperatively
MW, YH
Grade 2 postoperative thoracic procedure complication AE
CTCAE: E11910
a postoperative thoracic procedure complication AE when the patient is extubated more than 72 hrs postoperatively, but before tracheostomy indicated
MW, YH
Grade 3 postoperative thoracic procedure complication AE
CTCAE: E11911
a postoperative thoracic procedure complication AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
MW, YH
Grade 3 postoperative thoracic procedure complication AE
CTCAE: E11912
a prolapse of intestinal stoma AE that is asymptomatic; reducible
MW, YH
Grade 1 prolapse of intestinal stoma AE
CTCAE: E11915
a prolapse of intestinal stoma AE that is recurrent after manual reduction; local irritation or stool leakage; difficulty to fit appliance; limiting instrumental activities of daily living
MW, YH
Grade 2 prolapse of intestinal stoma AE
CTCAE: E11916
a prolapse of urostomy AE treated with local care or maintenance; minor revision indicated
MW, YH
Grade 2 prolapse of urostomy AE
CTCAE: E11922
a prolapse of urostomy AE that has dysfunctional stoma; elective operative intervention or major stomal revision indicated
MW, YH
Grade 3 prolapse of urostomy AE
CTCAE: E11923
a radiation recall reaction (dermatologic) AE that has faint erythema or dry desquamation
MW, YH
Grade 1 radiation recall reaction (dermatologic) AE
CTCAE: E11927
a radiation recall reaction (dermatologic) AE that has moderate to brisk erythema; patchy moist desquamation, mostly confined to skin folds and creases; moderate edema
MW, YH
Grade 2 radiation recall reaction (dermatologic) AE
CTCAE: E11928
a radiation recall reaction (dermatologic) AE that has moist desquamation in areas other than skin folds and creases; bleeding induced by minor trauma or abrasion
MW, YH
Grade 3 radiation recall reaction (dermatologic) AE
CTCAE: E11929
a radiation recall reaction (dermatologic) AE that has life-threatening consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated
MW, YH
Grade 4 radiation recall reaction (dermatologic) AE
CTCAE: E11930
a rectal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 rectal anastomotic leak AE
CTCAE: E11935
a seroma AE that is symptomatic; simple aspiration indicated
MW, YH
Grade 2 seroma AE
CTCAE: E11940
a seroma AE that is symptomatic, elective radiologic or operative intervention indicated
MW, YH
Grade 3 seroma AE
CTCAE: E11941
a small intestinal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 small intestinal anastomotic leak AE
CTCAE: E11945
a spermatic cord anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 spermatic cord anastomotic leak AE
CTCAE: E11951
a spinal fracture AE that has mild back pain; nonprescription analgesics indicated
MW, YH
Grade 1 spinal fracture AE
CTCAE: E11955
a spinal fracture AE that has moderate back pain; prescription analgesics indicated; limiting instrumental activities of daily living
MW, YH
Grade 2 spinal fracture AE
CTCAE: E11956
a spinal fracture AE that has severe back pain; hospitalization or intervention indicated for pain control (e.g., vertebroplasty); limiting self care activities of daily living; disability
MW, YH
Grade 3 spinal fracture AE
CTCAE: E11957
a spinal fracture AE that has life-threatening consequences; symptoms associated with neurovascular compromise
MW, YH
Grade 4 spinal fracture AE
CTCAE: E11958
a stenosis of gastrointestinal stoma AE that is symptomatic; IV fluids indicated <24 hrs; manual dilation at bedside
MW, YH
Grade 2 stenosis of gastrointestinal stoma AE
CTCAE: E11961
a stenosis of gastrointestinal stoma AE that has severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated
MW, YH
Grade 3 stenosis of gastrointestinal stoma AE
CTCAE: E11962
a tracheal hemorrhage AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated
MW, YH
Grade 3 tracheal hemorrhage AE
CTCAE: E11972
a tracheal obstruction AE that has partial asymptomatic obstruction on examination (e.g., visual, radiologic or endoscopic)
MW, YH
Grade 1 tracheal obstruction AE
CTCAE: E11976
a tracheal obstruction AE that is symptomatic (e.g., noisy airway breathing), no respiratory distress; medical intervention indicated (e.g., steroids); limiting instrumental activities of daily living
MW, YH
Grade 2 tracheal obstruction AE
CTCAE: E11977
a tracheal obstruction AE that has stridor; radiologic or endoscopic intervention indicated (e.g., stent, laser); limiting self care activities of daily living
MW, YH
Grade 3 tracheal obstruction AE
CTCAE: E11978
a tracheal obstruction AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation)
MW, YH
Grade 4 tracheal obstruction AE
CTCAE: E11979
a tracheostomy site bleeding AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated
MW, YH
Grade 3 tracheostomy site bleeding AE
CTCAE: E11984
an ureteric anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 ureteric anastomotic leak AE
CTCAE: E11990
an urethral anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 urethral anastomotic leak
CTCAE: E11996
a urostomy leak AESevere symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 urostomy leak AE
CTCAE: E12002
a urostomy obstruction AE that is symptomatic; dilation or endoscopic repair or stent placement indicated
MW, YH
Grade 2 urostomy obstruction AE
CTCAE: E12007
a urostomy site bleeding AE that has severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated
MW, YH
Grade 3 urostomy site bleeding AE
CTCAE: E12014
a urostomy stenosis AE that is symptomatic but no hydronephrosis, no sepsis or no renal dysfunction; dilation or endoscopic repair or stent placement indicated
MW, YH
Grade 2 urostomy stenosis AE
CTCAE: E12018
a urostomy stenosis AE that is symptomatic (e.g., hydronephrosis, or renal dysfunction); elective operative intervention indicated
MW, YH
Grade 3 urostomy stenosis AE
CTCAE: E12019
a uterine anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 uterine anastomotic leak AE
CTCAE: E12025
a vaginal anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 vaginal anastomotic leak AE
CTCAE: E12037
a vas deferens anastomotic leak AE that has severe symptoms; radiologic, endoscopic or elective operative intervention indicated
MW, YH
Grade 3 vas deferens anastomotic leak AE
CTCAE: E12043
a vascular access complication AE that has device dislodgement, blockage, leak, or malposition; device replacement indicated
MW, YH
Grade 2 vascular access complication AE
CTCAE: E12047
A vascular access complication AE that has deep vein or cardiac thrombosis; intervention indicated (e.g., anticoagulation, lysis, filter, invasive procedure)
MW, YH
Grade 3 vascular access complication AE
CTCAE: E12048
a vascular access complication AE that has embolic event including pulmonary embolism or life-threatening thrombus
MW, YH
Grade 4 vascular access complication AE
CTCAE: E12049
a blood antidiuretic hormone abnormal AE where hospitalization indicated
MW, YH
Grade 3 blood antidiuretic hormone abnormal AE
CTCAE: E12095
a blood corticotrophin decreased AE where hospitalization indicated
MW, YH
Grade 3 blood corticotrophin decreased AE
CTCAE: E12104
a carbon monoxide diffusing capacity decreased AE that is 3 - 5 units below lower limit of normal; for follow-up, a decrease of 3 - 5 units (ml/min/mm Hg) below the baseline value
MW, YH
Grade 1 carbon monoxide diffusing capacity decreased AE
CTCAE: E12113
a carbon monoxide diffusing capacity decreased AE that is 6 - 8 units below lower limit of normal; for follow-up, an asymptomatic decrease of greater than 5 - 8 units (ml/min/mm Hg) below the baseline value
MW, YH
Grade 2 carbon monoxide diffusing capacity decreased AE
CTCAE: E12114
a carbon monoxide diffusing capacity decreased AE that is an asymptomatic decrease of greater than 8 units drop; greater than 5 units drop along with the presence of pulmonary symptoms (e.g. , greater than Grade 2 hypoxia or greater than Grade 2 or higher dyspnea)
MW, YH
Grade 3 carbon monoxide diffusing capacity decreased AE
CTCAE: E12115
a cardiac troponin I increased AE that has levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer
MW, YH
Grade 1 cardiac troponin I increased AE
CTCAE: E12117
a cardiac troponin I increased AE that has levels consistent with myocardial infarction as defined by the manufacturer
MW, YH
Grade 3 cardiac troponin I increased AE
CTCAE: E12118
a cardiac troponin T increased AE that has levels above the upper limit of normal and below the level of myocardial infarction as defined by the manufacturer
MW, YH
Grade 1 cardiac troponin T increased AE
CTCAE: E12120
a cardiac troponin T increased AE that has levels consistent with myocardial infarction as defined by the manufacturer
MW, YH
Grade 3 cardiac troponin T increased AE
CTCAE: E12121
a CD4 lymphocytes decreased AE that is less than the lower limit of normal to 500/mm3 or 0.5 x 10e9 /L
MW, YH
Grade 1 CD4 lymphocytes decreased AE
CTCAE: E12123
a CD4 lymphocytes decreased AE that is less than 500 - 200/mm3; less than 0.5 - 0.2 x 10e9 /L
MW, YH
Grade 2 CD4 lymphocytes decreased AE
CTCAE: E12124
a CD4 lymphocytes decreased AE that is less than 200 - 50/mm3; less than 0.2 x 0.05 - 10e9 /L
MW, YH
Grade 3 CD4 lymphocytes decreased AE
CTCAE: E12125
a CD4 lymphocytes decreased AE that is less than 50/mm3; less than 0.05 x 10e9 /L
MW, YH
Grade 4 CD4 lymphocytes decreased AE
CTCAE: E12126
a CPK increased AE that is greater than the upper limit of normal to 2.5 times the upper limit of normal
MW, YH
Grade 1 CPK increased AE
CTCAE: E12133
a CPK increased AE that is greater than 2.5 -5 times the upper limit of normal
MW, YH
Grade 2 CPK increased AE
CTCAE: E12134
a CPK increased AE that is greater than 5 to 10 times the upper limit of normal
MW, YH
Grade 3 CPK increased AE
CTCAE: E12135
a CPK increased AE that is greater than 10 times the upper limit of normal
MW, YH
Grade 4 CPK increased AE
CTCAE: E12136
a fibrinogen decreased AE that is less than 1.0 - 0.75 times the lower limit of normal or less than 25% decrease from baseline
MW, YH
Grade 1 fibrinogen decreased AE
CTCAE: E12152
a fibrinogen decreased AE that is less than 0.75 - 0.5 times the lower limit of normal or 25 - less than 50% decrease from baseline
MW, YH
Grade 2 fibrinogen decreased AE
CTCAE: E12153
a fibrinogen decreased AE that is less than 0.5 - 0.25 times the lower limit of normal or 50 - less than 75% decrease from baseline
MW, YH
Grade 3 fibrinogen decreased AE
CTCAE: E12154
a fibrinogen decreased AE that is less than 0.25 times the lower limit of normal or 75% decrease from baseline or absolute value less than 50 mg/dL
MW, YH
Grade 4 fibrinogen decreased AE
CTCAE: E12155
a haptoglobin decreased AE that is less than the lower limit of normal
MW, YH
Grade 1 haptoglobin decreased AE
CTCAE: E12170
a pancreatic enzymes decreased AE that is less than the lower limit of normal and asymptomatic
MW, YH
Grade 1 pancreatic enzymes decreased AE
CTCAE: E12204
a pancreatic enzymes decreased AE that has an increase in stool frequency, bulk, or odor; steatorrhea
MW, YH
Grade 2 pancreatic enzymes decreased AE
CTCAE: E12205
a pancreatic enzymes decreased AE that has sequelae of absorption deficiency
MW, YH
Grade 3 pancreatic enzymes decreased AE
CTCAE: E12206
a vital capacity abnormal AE that has 90 - 75% of predicted value
MW, YH
Grade 1 vital capacity abnormal AE
CTCAE: E12221
a vital capacity abnormal AE that is less than 75 - 50% of predicted value; limiting instrumental activities of daily living
MW, YH
Grade 2 vital capacity abnormal AE
CTCAE: E12222
a vital capacity abnormal AE that is less than 50% of predicted value; limiting self care activities of daily living
MW, YH
Grade 3 vital capacity abnormal AE
CTCAE: E12223
a seizure AE that occurs in a pregnant women that follows a preeclampsia. Such a seizure is not related to an existing brain condition.
JS, YH
WEB: https://en.wikipedia.org/wiki/Eclampsia
WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000899.htm
10014129
eclampsia AE
a gastric disorder AE that shows the body under stress, causing acute erosion, bleeding and ulcers, stomach or duodenal mucosa damage collectively. The main clinical manifestations include upper gastrointestinal bleeding and a small perforation.
QL, YH
AGML AE
WEB: http://medmantic.com/wiki/Acute_Gastric_Mucosal_Lesion
急性胃黏膜损害
10000753
acute gastric mucosal lesion AE
a bowel sounds abnormal AE that shows an increased amount of bowel sounds.
QL, YH
WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm
hyperactive bowel sounds AE
肠鸣音亢进
10048720
bowel sounds increased AE
UMLS CUI: C0232694
a bowel sounds abnormal AE that shows a decreased amount of bowel sounds.
QL, YH
WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm
hypoactive bowel sounds AE
肠鸣音减弱
bowel sounds decreased AE
UMLS CUI: C0232695
a gastrointestinal disorder AE that shows an abnormal amount of bowel sounds.
QL, YH
WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm
肠鸣音异常
bowel sounds abnormal AE
UMLS CUI: C0159060
a bowel sounds abnormal AE that shows an cesssation of any bowel sounds.
QL, YH
WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003137.htm
肠鸣音停止
肠鸣音消失
cessation of bowel sounds AE
UMLS CUI: C0857330
a migraine AE which shows a migraine preceded or accompanied by sensory warning signs or symptoms, such as flashes of light, blind spots, or tingling in your hand or face.
SJ, YH
WEB: http://www.mayoclinic.org/diseases-conditions/migraine-with-aura/basics/definition/con-20030404
10027607
migraine with aura AE
a hearing disorder AE with an abnormally disproportionate increase in the sensation of loudness in response to auditory stimuli of normal volume
QL, YH
WEB: https://en.wikipedia.org/wiki/Hyperacusis
听觉过敏
10052526
hyperacusia AE
a back pain AE that occurs at the low back
QL, YH
low back pain AE
WEB: https://en.wikipedia.org/wiki/Low_back_pain
下背痛
腰痛
lumbago AE
a paralysis AE which occurs in a single limb, usually an arm
SJ, YH
WEB: http://en.wikipedia.org/wiki/Monoplegia
10027926
monoplegia AE
a behavior and neurological AE which results in abnormal, disturbed or impaired functioning of a muscle, nerve, or center that affects or produces movement
SJ, YH
WEB: http://connection.ebscohost.com/c/reference-entries/23076155/motor-dysfunction
10061296
motor dysfunction AE
a discomfort AE that occurs at the musculoskeletal level and results in musculoskeletal pain that affects the bones, muscles, ligaments, tendons, and nerves
SJ, YH
musculoskeletal pain AE
WEB: http://my.clevelandclinic.org/health/diseases_conditions/hic_musculoskeletal_pain
10053156
musculoskeletal discomfort AE
a musculoskeletal and connective tissue AE which results in a disease or abnormal condition of the musculoskeletal system
SJ, YH
10048592
musculoskeletal disorder AE
a urinary system AE which shows reduced excretion of urine
SJ, YH
WEB: http://c.merriam-webster.com/medlineplus/oliguria
10030302
oliguria AE
a hypotension AE that happens during a medical procedure
SJ, YH
WEB: http://www.mayoclinic.org/diseases-conditions/low-blood-pressure/basics/definition/con-20032298
10062300
procedural hypotension AE
a digestive system AE that occurs at esophagus
YH, MW
食道副作用
esophagus AE
a digestive system AE that occurs at anus
YH, MW
anus AE
a digestive system AE that occurs at duodenum
MW, YH
duodenum AE
QL, YH
URL http://howshealth.com/kidney-pain-location-causes-symptoms-treatment/#percussion
肾区叩击痛
a pain AE that shows the pain in the kidney area identified by a percussion procedure.
kidney area percussion pain AE
a medical procedure by which a medical professional investigates the body of a patient for signs of disease.
QL, YH
WEB: http://www.webmd.com/a-to-z-guides/annual-physical-examinations
WEB: https://en.wikipedia.org/wiki/Physical_examination
10071941
physical examination
a physical test by which a surface is tapped to determine the underlying structure, and is used in clinical examinations to assess the condition of the thorax or abdomen.
QL, YH
percussion test
WEB: https://en.wikipedia.org/wiki/Percussion_(medicine)
10051720
percussion procedure
a urine analysis result abnomal AE that shows cylindrical structures produced by the kidney and present in the urine.
QL, YH
urinary casts present AE
WEB: http://medical-dictionary.thefreedictionary.com/cylindruria
管型尿
10011730
10067534
cylindruria AE
a hepatitis AE that resutls in a hepatitis A viral infection.
JX, YH
hepatitis A AE
WEB: https://en.wikipedia.org/wiki/Hepatitis_A
10019719
hepatitis A AE
a connective tissue disorder AE that shows an inflammation of the fascia, the connective tissue surrounding muscles, blood vessels, and nerves.
JX, YH
WEB: https://en.wikipedia.org/wiki/Fasciitis
筋膜炎
10016228
fasciitis AE
A tendon disorder AE that led to the formation of fibrous tissue in the tendon area
JX, YH
WEB: http://study.com/academy/lesson/fibrous-connective-tissue-function-types.html
10016662
fibrosis tendinous AE
a fasciitis AE that shows an inflammation of the muscle fascia, the connective tissue surrounding muscles.
JX, YH
WEB: https://en.wikipedia.org/wiki/Fasciitis
肌筋膜炎
10052443
myofascitis AE
an eye disorder AE that causes visual disturbance and interfere with normal sight.
JX, YH
WEB: http://www.healthline.com/symptom/visual-disturbance
10047543
visual disturbance AE
a cognitive disturbance AE that has mild cognitive disability; not interfering with work/school/life performance; specialized educational services/devices not indicated
MW, YH
Grade 1 cognitive disturbance AE
CTCAE: E12618
a cognitive disturbance AE that has moderate cognitive disability; interfering with work/school/life performance but capable of independent living; specialized resources on part time basis indicated
MW, YH
Grade 2 cognitive disturbance AE
CTCAE: E12619
a cognitive disturbance AE that has severe cognitive disability; significant impairment of work/school/life performance
MW, YH
Grade 3 cognitive disturbance AE
CTCAE: E12620
an abortion AE that results in a retention of dead products of conception in utero for more than 8 weeks.
JX, YH
WEB: http://medical-dictionary.thefreedictionary.com/missed+abortion
10000230
abortion missed AE
an edema AE that has an outcome of swelling in the eye.
JX, YH
10052139
eye edema AE
Oral discomfort AE is a discomfort AE that shows an uncomfortable feeling in the oral.
JX, YH
口腔不适
10030973
oral discomfort AE
a female reproductive system AE that has an outcome of the presence of a fluid-filled sac within a patient's ovary.
JX, YH
WEB: https://en.wikipedia.org/wiki/Ovarian_cyst
10033132
ovarian cyst AE
a female reproductive system AE that occurs in the placental area.
JX, YH
WEB: https://en.wikipedia.org/wiki/Placental_disease
10035132
placental disorder AE
an inflammation AE that occurs at the central nervous system.
JX, YH
WEB: https://en.wikipedia.org/wiki/Central_nervous_system_disease
中枢神经系统炎症
central nervous system inflammation AE
a nervous system AE that has outcome of lesion in the area of central nervous system.
JX, YH
WEB: http://www.emedicinehealth.com/brain_lesions_lesions_on_the_brain/article_em.htm
10051290
central nervous system lesion AE
a behavioral and neurological AE is characterized by motor coordination problems with daily activities.
JX, YH
WEB: http://www.healthline.com/symptom/clumsiness
10009696
clumsiness AE
a behavioral and neurological AE is a deficiency in the ability to write, primarily handwriting, but also coherence.
JX, YH
WEB: https://en.wikipedia.org/wiki/Dysgraphia
10058319
dysgraphia AE
a sensory neuropathy AE than is the medical term for a sensation that exactly resembles that of small insects crawling on (or under) the skin.
JX, YH
WEB: https://en.wikipedia.org/wiki/Formication
10017062
formication AE
a paresis AE that shows muscle weakness of the entire left or right side of the body.
JX, YH
WEB: https://en.wikipedia.org/wiki/Hemiparesis
轻偏瘫
10019465
hemiparesis AE
an immunology and allergy investigation result abnormal AE that results in an increased level of an immunoglobulin.
JX, YH
WEB: http://www.webmd.com/a-to-z-guides/immunoglobulins
immunoglobulin increased AE
a urinary system AE that shows abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.
JX, YH
WEB: http://sideeffects.embl.de/se/C0042035/pt
10027561
micturition disorder AE
a muscle twitch AE that has an outcome of contractions involuntary of muscle.
JX, YH
肌肉不自觉收缩
10028293
muscle contractions involuntary AE
a nervous system AE that describes any neurologic deficit related to the spinal cord.
JX, YH
WEB: https://en.wikipedia.org/wiki/Myelopathy
脊髓病
10028570
myelopathy AE
a optic neuritis AE that has outcome of optic neuritis in retrobulbar.
JX, YH
WEB: https://en.wikipedia.org/wiki/Optic_neuritis
球后视神经炎
10030945
optic neuritis retrobulbar AE
a eye AE that is an area of partial alteration in the field of vision consisting of a partially diminished or entirely degenerated visual acuity that is surrounded by a field of normal – or relatively well-preserved – vision.
JX, YH
WEB: https://en.wikipedia.org/wiki/Scotoma
暗点
10039729
scotoma AE
A thyroiditis AE that is a disease in which the body interprets the thyroid glands and its hormone products T3, T4 and TSH as threats, therefore producing special antibodies that target the thyroid’s cells, thereby destroying it.
JX, YH
WEB: https://en.wikipedia.org/wiki/Autoimmune_thyroiditis
自我免疫性甲状腺炎
10049046
autoimmune thyroiditis AE
a colitis AE that is a disease that causes inflammation and sores (ulcers) in the lining of the large intestine.
JX, YH
ulcerative colitis AE
WEB: http://www.webmd.com/ibd-crohns-disease/ulcerative-colitis/ulcerative-colitis-topic-overview
溃疡性结肠炎
10009900
colitis ulcerative AE
an abnormal stool AE that shows pale or clay-colored stool.
JX, YH
faeces pale AE
WEB: http://www.healthline.com/symptom/pale-stools
大便苍白
10016102
feces pale AE
a tumor AE that is a group of blood cell tumors that develop from lymphatic cells.
JX, YH
WEB: https://en.wikipedia.org/wiki/Lymphoma
淋巴瘤
10025310
lymphoma AE
a paresis AE that affects a single limb, usually an arm.
JX, YH
WEB: https://en.wikipedia.org/wiki/Monoplegia
单肢轻瘫
10027925
monoparesis AE
a eye AE that refers to weakness (-paresis) or paralysis (-plegia) of one or more extraocular muscles which are responsible for eye movements.
JX, YH
WEB: https://en.wikipedia.org/wiki/Ophthalmoparesis
眼肌麻痹
10030875
ophthalmoplegia AE
a eye AE that has outcome of slight differences in pupil size.
JX, YH
WEB: https://www.nlm.nih.gov/medlineplus/ency/article/003314.htm
瞳孔不等
10037538
pupils unequal AE
quadriplegia AE is paralysis caused by illness or injury that results in the partial or total loss of use of all four limbs and torso.
JX, YH
Tetraplegia
WEB: https://en.wikipedia.org/wiki/Tetraplegia
四肢麻痹
10037714
quadriplegia AE
a CSF white blood cell count increased AE with more than the normal number of lymphocytes in cerebrospinal fluid (CSF).
JX, YH
脑脊液细胞增多
10035551
pleocytosis AE
a behavior and neurological AE that shows an decreased preformance
JX, YH
WEB: https://en.wikipedia.org/wiki/Performance_status
体能下降
10048919
performance status decreased AE
a skin AS that shows a mass at the skin.
JX, YH
skin tumor AE
10067868
skin mass AE
an abnormal stool AE that shows an abnomal color in the feces.
JX, YH
faeces discoloured AE
WEB: http://www.buzzle.com/articles/stool-colors-and-what-they-mean.html
10016100
feces discolored AE
an investigation result abnormal AE that shows an abnormal ultrasound scan result.
JX, YH
WEB: http://www.nhs.uk/conditions/ultrasound-scan/Pages/Introduction.aspx
10061606
ultrasound scan abnormal AE
an injection site AE that shows some substance release from an injection site.
JX, YH
10065600
injection site discharge AE
a tumor AE that has an outcome of the presense of a mass that arises from the axillary.
JX, YH
WEB: http://www.rightdiagnosis.com/sym/axillary_mass.htm
腋窝肿块
10049021
axillary mass AE
a behavioral and neurological AE that involves a slowing-down of thought and a reduction of physical movements in an individual.
JX, YH
motormental retardation AE
psychomotor impairment AE
WEB: https://en.wikipedia.org/wiki/Psychomotor_retardation
精神运动性阻滞
10037213
psychomotor retardation AE
an abscess AE that occurs at an injection-site. Note that an abscess is a collection of pus that has built up within a tissue of the body.
JX, YH
WEB: https://en.wikipedia.org/wiki/Abscess
10022044
injection site abscess AE
an ulcer AE that occurs at an injection-site.
JX, YH
WEB: https://en.wikipedia.org/wiki/Ulcer
10022105
injection site ulcer AE
a viral infection AE that is caused by a disseminated Bacillus Calmette-Guerin bacterial infection.
JX, YH
disseminated Bacillus Calmette-Guerin infection AE
10069636
disseminated BCG infection AE
a paresis AE that shows a muscular weakness affecting all four extremities.
JX, YH
quadriparesis AE
WEB: http://www.medilexicon.com/medicaldictionary.php?t=91062
tetraparesis AE
a menstrual disorder AE that shows an extremely light menstrual blood flow
QL, YH
hypomenorrhoea AE
WEB: https://en.wikipedia.org/wiki/Hypomenorrhea
月经减少
10021032
hypomenorrhea AE
a menstrual disorder AE that shows a menstrual period with abnormally heavy flow and falls under the larger category of abnormal uterine bleeding (AUB)
QL, YH
hypermenorrhea AE
WEB: https://en.wikipedia.org/wiki/Menorrhagia
menorrhagia AE
a male reproductive system AE in which spermatozoa in seminal fluid are dead or motionless
QL, YH
WEB: https://en.wikipedia.org/wiki/Necrospermia
死精
10074729
necrospermia AE
MP: MP_0009325
a reproductive system AE that results in diminished ability to produce live offspring
JX, LW, YH
WEB: https://en.wikipedia.org/wiki/Infertility
生育能力下降
10042391
subfertility AE
MP: MP_0001921
a reproductive system AE that results in an inability to conceive for at least one year after trying and having unprotected sex.
QL, YH
WEB: http://www.mayoclinic.org/diseases-conditions/infertility/basics/definition/con-20034770
不孕不育
10021926
infertility AE
MP: MP_0001921
an endocrine investigation result abnormal AE that is characterized by a lower than normal level of estrogen, the primary sex hormone in women
QL, YH
estrogen deficiency AE
hypoestrogenism AE
WEB: http://www.md-health.com/Low-Estrogen.html
WEB: https://en.wikipedia.org/wiki/Hypoestrogenism
性激素水平下降
10015519
low estrogen level AE
a hemorrhage AE that occurs at the uterus, but it is not related to menstruation. The irregular and unpredictable bleeding usually comes from a dysfunctional endometrium.
QL, YH
WEB: http://emedicine.medscape.com/article/257007-overview
功能性子宫出血
10013908
dysfunctional uterine bleeding AE
MESH: D008796
a testicular disorder AE that has a loss of testicular volume
QL, YH
WEB: https://en.wikipedia.org/wiki/Testicular_atrophy
睾丸萎缩
10043298
testicular atrophy AE
an aplastic anemia AE that results in the suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production.
QL, YH
PRCA AE
red-cell aplasia, pure
WEB: http://emedicine.medscape.com/article/205695-overview
纯红再障性贫血
pure red cell aplasia AE
MESH: D012010
a paralysis AE that shows an impairment in motor or sensory function of the lower extremities.
YH, JX
WEB: https://en.wikipedia.org/wiki/Paraplegia
10033892
paraplegia AE
a cutaneous vasculitis AE that results in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the kin.
QL, YH
WEB: https://www.nlm.nih.gov/medlineplus/ency/article/000874.htm
皮肤变应性血管炎
allergic cutaneous vasculitis AE
DO: DOID_11450
a skin hyperpigmentation AE that shows the occurrence of pigmented patches on the tongue and buccal mucousmembranes.
QL, YH
WEB: http://www.medilexicon.com/medicaldictionary.php?t=53725
皮肤黑斑病
melanoplakia AE
SNOMEDCT: 84647002
an erythema AE that showns an erythematous eruption characterized by inflammatory nodules that are usually tender, multiple, and bilateral. Such a symptom is commonly associated with drug reactions or infection.
QL, YH
erythemanodosum AE
WEB: https://en.wikipedia.org/wiki/Erythema_nodosum
结节性红斑
10015226
erythema nodosum AE
HPO: HP_0012219
MeSH: D004893
a muscle spasm AE that occurs when the contraction of a spasm is sustained or continuing. Such a spasm is generally severe because is is often caused by diseases that affect the central nervous system or brain, such as tetanus, rabies, and cerebral palsy.
QL, YH
WEB: http://medical-dictionary.thefreedictionary.com/tonic+spasm
强直性痉挛
tonic spasm AE
a menstrual disorder AE that results in frequent menses amd the menstrual cycles lasting less than 21 days.
QL, YH
月经频繁
10070501
polymenorrhea AE
HP: HP_0400007
a menstrual disorder AE that shows an outcome of a shortened time of menstrual period
QL, YH
short menstrual period AE
WEB: http://www.everydayhealth.com/pms/short-periods.aspx
经期缩短
shortened menstrual period AE
a menstrual disorder AE that shows an outcome of a prolonged duration of menstrual period
QL, YH
prolonged menstruation AE
WEB: http://www.healthline.com/symptom/menstrual-irregularity
经期延长
prolonged menstrual period AE
musculoskeletal stiffness AE that occurs at the neck and is typically characterized by soreness and difficulty moving the neck, especially when trying to turn the head to the side.
QL, YH
stiff neck AE
WEB: http://www.spine-health.com/conditions/neck-pain/stiff-neck-causes-symptoms-and-treatment
颈项强直
10028843
neck stiffness AE
stiffness of the neck AE
a female reproductive system AE that occurs at the ovaries where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40.
QL, YH
primary ovarian insufficiency AE
WEB: http://www.mayoclinic.org/diseases-conditions/premature-ovarian-failure/basics/definition/con-20028351
WEB: https://www.nlm.nih.gov/medlineplus/prematureovarianfailure.html
卵巢早衰
premature ovarian failure AE
DO: DOID_5426
a skin adverse event that has an outcome of a discontinuity of the skin exhibiting incomplete loss of the epidermis, a lesion that is moist, circumscribed, and usually depressed.
QL, YH
10040840
skin erosion AE
HP: HP_0200041
a hematopoietic system AE that has an outcome of an arrest of the formation of blood cellular components.
QL, YH
WEB: https://en.wikipedia.org/wiki/Haematopoiesis
造血功能障碍
arrest of hematopoiesis AE
an arrest of hematopoiesis AE that occurs quickly
QL, YH
WEB: https://en.wikipedia.org/wiki/Haematopoiesis
急性造血功能障碍
acute arrest of hematopoiesis AE
an ulcer AE that occurs at the scrotum
QL, YH
阴囊破溃
scrotum ulcer AE
SNOMEDCT: 9750001
a skin adverse event that inherited chronic noninflammatory skin disease manifested by vesicles, large bullae (blisters), and skin erosions which often result from trauma.
QL, YH
epidermolysis bullosa type eruption AE
WEB: http://www.mayoclinic.org/diseases-conditions/epidermolysis-bullosa/basics/definition/con-20032497
大疱性表皮坏死松解症
10014989
epidermolysis bullosa AE
a female reproductive system AE that occurs in the uterus
JX, YH
WEB: https://en.wikipedia.org/wiki/Uterus
uterine AE
a reproduction system inflammation AE that occurs in the endometrium, the inner lining of the uterus.
MW, YH
WEB: https://en.wikipedia.org/wiki/Endometritis
子宫内膜炎
10014791
endometritis AE
an inflammation AE which occurs in the female reproduction system
YH, JX
female reproduction system inflammation AE
a reproduction system inflammation AE that occurs in the placenta.
JX, YH
WEB: https://en.wikipedia.org/wiki/Placenta
胎盘炎
10014791
placentitis AE
a female reproductive system AE that occurs when the baby does not exit the pelvis during childbirth due to being physically blocked, even though the uterus is contracting normally.
JX, YH
obstructed labor AE
obstructed labour AE
WEB: https://en.wikipedia.org/wiki/Obstructed_labour
难产
dystocia AE
a pneumonia AE that is caused by a mycotic infection
JX, YH
WEB: https://en.wikipedia.org/wiki/Fungal_pneumonia
真菌性肺炎
mycotic pneumonia AE
an inflammation AE that refers to inflammation of the serous tissues of the body, the tissues lining the lungs (pleura), heart (pericardium), and the inner lining of the abdomen (peritoneum) and organs within.
JX, YH
WEB: https://en.wikipedia.org/wiki/Serositis
浆膜炎
10058556
serositis AE
a female reproduction system inflammation AE that occurs in the wall of the uterus.
JX, YH
WEB: https://en.wikipedia.org/wiki/Metritis
子宫炎
10066270
metritis AE
an abscess AE where the abscess is filled with pus.
Note: based on the website: https://www.quora.com/What-is-a-purulent-abscess, it appears that the words purulent abscess are actually redundant. Purulent means pus. Abscess is a space or pocket in the body filled with pus.
JX, YH
化脓性脓肿
purulent abscess AE
a clostridial infection AE that results in muscle spasms.
JX, YH
lockjaw AE
WEB: https://en.wikipedia.org/wiki/Tetanus
破伤风
10043376
tetanus AE
a abscess AE that shows a collection of pus found near the rectum.
JX, YH
WEB: http://www.webmd.com/a-to-z-guides/anal-abscess
直肠脓肿
10048947
rectal abscess AE
a brucellosis AE that shows an acute disease stage.
JX, YH
WEB: https://en.wikipedia.org/wiki/Brucellosis
急性布氏杆菌病
acute brucellosis AE
a lymphadenopathy AE where the lymphadenopathy occurs in the supraclavicular lymph nodes.
JX, YH
WEB: https://en.wikipedia.org/wiki/Lymphadenopathy
锁骨上淋巴结病
supraclavicular lymphadenopathy AE
a pain AE that shows a person with generalized aches and pains in multiple areas of the body.
JX, YH
WEB: http://www.everydayhealth.com/symptom-checker/body-aches
体痛
body ache AE
an inflammation AE that occurs in the kidney tissue, calyces, and renal pelvis.
JX, YH
WEB: https://en.wikipedia.org/wiki/Pyelonephritis
肾盂肾炎
10037596
pyelonephritis AE
a bacterial infection AE that is caused by the infection with Brucella, a Gram-negative bacterium. The infected animals can be human or a variety of mammal animals.
JX, YH
Bang's disease AE
Crimean fever AE
Gibraltar fever AE
Malta fever AE
Maltese fever AE
Mediterranean fever AE
rock fever AE
undulant fever AE
WEB: https://en.wikipedia.org/wiki/Brucellosis
布氏杆菌病
brucellosis AE
an infection AE that is caused by a parasite.
YH, JX
WEB: https://en.wikipedia.org/wiki/Parasitic_disease
parasitic infection AE
a parasitic infection AE that is caused by a heminth, i.e., a parasitic worm, in the location of intestine.
JX, YH
WEB: https://en.wikipedia.org/wiki/Helminthiasis
肠道蠕虫病
intestinal helminthiasis AE
a liver AE that has an outcome of the diffusion or accumulation of substances in the liver.
JX, YH
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/20806348
WEB: https://en.wikipedia.org/wiki/Infiltration_(medical)
肝脏浸润
liver infiltration AE
an epididymitis AE where the epidiymis is filled up with lymphocytes and plasma cells.
JX, YH
WEB: http://www.merriam-webster.com/medical/lymphoplasmacytic
WEB: https://en.wikipedia.org/wiki/Epididymitis
淋巴浆细胞性附睾炎
lymphoplasmacytic epididymitis AE
a testicular disorder AE that results in a discomfort or pain of the epidiymis, a curved structure at the back of the testicle in which sperm matures and is stored.
JX, YH
WEB: https://en.wikipedia.org/wiki/Epididymitis
epididymitis AE
a pneumonia AE that results in the dissemination of histiocytes in the lung.
JX, YH
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/17882900
WEB: https://en.wikipedia.org/wiki/Pneumonia
弥漫性组织细胞性肺炎
disseminated histiocytic pneumonia AE
a myocarditis AE where the heart muscle is filled with lymphocytes and plasma cells that are not normally seen.
JX, YH
WEB: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001204/
淋巴浆细胞性心肌炎
lymphoplasmacytic myocarditis AE
a syndrome AE in which the immune system begins to recover from an immunosuppression or AIDS, but then responds to a previously acquired opportunistic infection with an overwhelming inflammatory response that paradoxically makes the symptoms of infection worse.
JX, YH
IRIS AE
immune recovery syndrome AE
WEB: https://en.wikipedia.org/wiki/Immune_reconstitution_inflammatory_syndrome
10065042
immune reconstitution inflammatory syndrome AE
a role that exists in a cellular and molecular interaction
YH
role in cellular and molecular interaction
NDF-RT: N0000000223
a diarrhea AE that occurs when the bile acids are not reabsorbed into the bloodstream and enter the large bowel (colon), which causes abnormally high levels of water and salts in the large bowel and the formation of watery diarrhoea.
YH
bile acid malabsorption AE
WEB: http://patient.info/health/bile-acid-malabsorptiondiarrhoea-leaflet
WEB: https://en.wikipedia.org/wiki/Bile_acid_malabsorption
WEB: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002596/
10069703
bile acid diarrhoea AE
an adverse event that has an outcome of nutrition disorder, which can be caused by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods.
YH
nutrition disorder AE
WEB: http://www.who.int/topics/nutrition_disorders/en/
营养失调
nutritional disorder AE
a nutrional disorder AE that has an outcome of malnutrition, a condition resulting from insufficient nutrients in the body.
YH
WEB: https://medlineplus.gov/ency/article/000404.htm
营养不良
malnutrition AE
a gastrointestinal disorder AE that has an outcome of the presence of very large numbers of bacteria growing in the small intestine
YH
BLS AE
BOS AE
SIBO AE
bacterial overgrowth syndrome AE
blind loop syndrome AE
small bowel bacterial overgrowth AE
WEB: https://en.wikipedia.org/wiki/Blind_loop_syndrome
WEB: https://medlineplus.gov/ency/article/000222.htm
small intestinal bacterial overgrowth AE
an edema face AE where the face has gradually swollen into a rounded shape
YH
WEB: http://www.webmd.com/a-to-z-guides/moon-facies
moon face AE
a behavioral and neurological AE that has an outcome of impaired daily self care activities.
KY, YH
ADL impaired AE
WEB: https://en.wikipedia.org/wiki/Activities_of_daily_living
10050954
activities of daily living impaired AE
a hematology investigation result abnormal AE that is characterized by an abnomalty in the antibody level in the blood
YH, KY
antibody test abnormal AE
an antibody test abnormal AE that shows positive antinuclear antibody, which often attack a person's own cell nucleus.
YH, KY
ANA test abnormal AE
URL: http://www.mayoclinic.org/tests-procedures/ana-test/basics/definition/prc-20014566
In most cases, a positive ANA test indicates that your immune system has launched a misdirected attack on your own tissue — in other words, an autoimmune reaction. But some people have positive ANA tests even when they're healthy.
Ref: http://www.mayoclinic.org/tests-procedures/ana-test/basics/definition/prc-20014566
antinuclear antibody positive AE
A nervous system AE which refers to an imbalance problem in the part of the nervous system that controls involuntary actions
KY, YH
https://medlineplus.gov/autonomicnervoussystemdisorders.html#cat59
10003840
autonomic nervous system imbalance AE
A CSF test result abnormal AE with high glucose levels in the cerebrospinal fluid.
KY, YH
https://en.wikipedia.org/wiki/CSF_glucose
10050763
CSF glucose increased AE
A CSF test result abnormal AE with high immunoglobin levels in the cerebrospinal fluid.
KY, YH
https://labtestsonline.org/understanding/conditions/multiplesclerosis/start/2/
10064338
CSF immunoglobulin increased AE
A facial paralysis AE that refers to temporary or permanent weakness of the facial muscles on one or both sides of the face.
KY, YH
http://www.facialpalsy.org.uk/about-facial-palsy/what-is-facial-palsy/1395/
10016060
facial palsy AE
A bone AE that refers to structural failure in a disc and advanced signs of aging.
KY, YH
https://www.ncbi.nlm.nih.gov/pubmed/16915105
10061246
intervertebral disc degeneration AE
A behavioral and neurological test abnormal AE result that has an abnormal outcome in lumbar puncture involving pain or numbness to the legs, lower back pain, headaches, risk of infection, or risk of bleeding in the spinal canal.
KY, YH
http://www.hopkinsmedicine.org/healthlibrary/test_procedures/neurological/lumbar_puncture_lp_92,p07666/
10025000
lumbar puncture abnormal AE
A behavioral and neurological test abnormal AE that involves an abnormal outcome in the series of simple questions and noninvasive tests in a neurological examination that provides crucial information about the nervous system.
KY, YH
http://www.healthcommunities.com/brain-nerve-tests/what-is-a-neuro-exam.shtml
10056832
neurological examination abnormal AE
A paralysis AE characterized by extreme muscle weakness and loss of muscle tone.
KY, YH
www.brainandspinalcord.org/flaccid-paralysis/
10033809
paralysis flaccid AE
A paralysis AE on the peroneal nerve leading to loss of movement or sensation on the foot and leg and may lead to complete weakness or paralysis of the foot or leg.
KY, YH
https://medlineplus.gov/ency/article/000791.htm
10034701
peroneal nerve palsy AE
a medical intervention site that is used for injection of a substance.
YH, SS, ZX
injection site
obsolete class
has_specified_input
has_specified_output