Jean-François Ethier
An ontology of drug prescriptions
Ryeyan Taseen
Adrien Barton
has minimum range value
has maximum range value
a treatment that has as participants an extended organism and a drug product and that results in part of the drug product being located in the extended organism.
We suggest that drug administration be removed as a subclass of treatment or that it be renamed drug treatment.
1. Not all administrations of a drug product to an organism are an instance of treatment. They could be for example, for prophylaxis, for diagnosis, etc.
2. Not all instances of drug administrations in a treatment satisfy the definition of treatment, where it would need to result in an alleviation of signs/symptoms. (e.g. first dose administration of an antibiotic).
administration de médicament
spécification de dose
a condition describing the time elapsed since a drug dispensing process.
une condition de temps écoulé depuis une distribution de médicaments.
condition indiquant le temps écoulé depuis une distribution
time elapsed since dispensing condition
"For patient: Mr Smith, should exercise for at least 30 minutes, 3 times weekly. signed Dr. Ronnie Shuz. Date: 15/11/01"
A document authored by a health care provider that specifies how to realize some health care process for a particular patient.
Un document créé par un fournisseur de soin indiquant comment réaliser une partie d'un processus de santé pour un patient particulier.
prescription
health care prescription
prescription de santé
An author identification where the author is a particular health care provider and the document authored is a prescription.
Une identification d'auteur où l'auteur est un fournisseur de soins particulier et le document en question est une prescription.
identification de prescripteur
prescriber identification
A written name denoting a particular patient.
Un nom écrit faisant référence à un patient particulier.
identification d'un patient
patient identification
La masse d'un aggrégat d'ingrédient actif.
The mass of an active ingredient aggregate.
active ingredient aggregate mass
masse d'aggrégat d'ingrédient actif
A textual entity that denotes the time of document creation.
Une entité textuelle indiquant l'instant de création d'un document.
the granular time at which the author considers the document whole, ie ready for interpretation
document creation time identification
identification de l'instant de création d'un document
A document creation time identification where the document is a prescription.
Une identification de l'instant de création d'un document qui est une prescription médicale.
health care prescription time identification
identification du temps de création d'une prescription médicale
drug administration and dispensing specification
An information content entity that specifies a characteristic of a drug product that is prescribed.
prescribed drug product characteristic specification
A data item that is about a drug product.
Un élément de données qui fournit une information sur un médicament.
drug product information item
élément d'information sur un médicament
John Smith taking 1 mg of Ativan from his dosette every 12 hours, alleviating the anxiety produced by his usual routine at a long-term care facility, as hypothesized by his physician, Dr. Hazard.
A treatment composed of one or more dose administrations.
Un traitement composé d'une ou plusieurs administrations de doses.
drug treatment
traitement médicamenteux
"5 PM on January 1st 2016"
spécification d'instant temporel
temporal instant specification
"IM or IV" in "Administrate IM or IV"
An information content entity that specifies the route(s) of administration of a drug product.
Une entité informationnelle indiquant la ou les voies d'administration d'un médicament.
mode of administration specification
route of administration specification
spécification de voie d'administration
"1 mg" (of lorazepam), "5 mg" (of metoprolol)
A mass value specification that specifies the mass of an active ingredient aggegate.
Une spécification de valeur de masse indiquant la masse d'un aggrégat d'ingrédient actif.
active ingredient mass value specification
spécification de valeur de masse d'ingrédient actif
"80mg" in "Aspirin 80mg oral tablet"
An information content entity thatspecifies the strength of a prescribed drug product.
drug strength specification
"Prescription for John Smith : Ativan 2mg tablets, take 1 tablet twice daily by mouth as needed if anxious, dispense 60 tablets, renew 12 times. Signed by Dr Hazard. Date: 15/10/29"
A health care prescription specifying how to realize a drug administration.
Une ordonnance indiquant une administration de médicaments.
drug prescription
prescription de médicaments
A drug product information item that is about one or more magnitudes of biological activity, masses or quantities of active ingredient aggregate per unit quantity of a drug product.
Un élément d'information sur un médicament à propos de une ou plusieurs magnitudes d'activité biologique, masses ou quantités d'aggrégat d'ingrédient actif par unité de médicament.
drug strength item
élément d'information de force médicamenteuse
"1 mg of lorazepam per tablet"
"21 mg of nicotine per patch"
"This tablet contains 12.5 mg of hydrochlorothiazide and 4 mg of perindopril" is one instance of drug strength per discrete dose form, that has part two active ingredient mass specifications.
A drug strength item where the unit quantity is a discrete solid dose form.
Un élément d'information de force médicamenteuse où l'unité de quantité de médicament est une forme de dose médicamenteuse solide et discrète.
drug strength per discrete dose form item
élément d'information de force médicamenteuse par forme discrète
"500 mg/mL liquid"
A drug strength item where the unit quantity is a unit of volume.
Un élément d'information de force médicamenteuse où l'unité de quantité de médicament est une unité de volume.
drug strength per volume unit item
élément d'information de force médicamenteuse par unité de volume
"60 mg/g powder"
A drug strength item where the unit quantity is the mass of the drug product.
Un élément d'information de force médicamenteuse où l'unité de quantité de médicament est une unité de masse.
drug strength per mass unit item
élément d'information de force médicamenteuse par unité de masse
duration of dose administration specification
"inject over 30 seconds"
"infuse over 12 hours"
An information content entity that specifies the duration during which a dose should be administered continuously.
This class is meant to be used in cases where the quantity of drug product to be delivered during a single dose administration is prescribed in advance and the dose administration process has a clear end in time relative to the beginning of the process (such that if one knows the instant it started, one would know the instant it ended and vice versa). e.g. 500cc of NS over 2 hours x1
duration of administration specification
spécification de durée d'administration de dose
'begin administration at 50cc/h'
An information content entity that specifies the initial rate at which a dose should be administered.
initial rate of administration specification
spécification de débit initial d'administration de dose
"lorazepam" in "This tablet of Ativan 1 mg contains lorazepam"
"acetaminophen" in "This tablet of Tylenol 500mg contains acetaminophen"
A drug product information item that is about an active ingredient in a drug product.
Un élément d'information sur un médicament dénotant un de ses ingrédients.
drug active ingredient item
élément d'information d'ingrédient médicamenteux
'Lopresor'
A drug product name given to a non-generic drug product by the pharmaceutical company that produces it
Un nom de médicament non-générique donné par l'entreprise pharmaceutique qui le produit.
nom propriétaire d'un médicament non-générique
non-generic drug product proprietary name
eg. oral tablet, topical cream, IV liquid, oral liquid
A drug product information item that is about a dose form of a drug product
Un élément d'information sur un médicament concernant sa forme (par exemple pilule orale, crème topique, liquide intraveineux, liquide oral).
This will need to be divided into an item referring to the 3D configuration of a dose and an item referring to the vehicle that dose is contained in.
dose form item
drug dose form item
élément d'information de forme médicamenteuse
John Smith swallowing a 1mg lorazepam tablet.
The continuous infusion of 450 mg of amiodarone over 12 hours into a vein of Harry Thymia
A process that has as participants an extended organism and a drug product and that results in a specified portion of the drug product (a single dose) being located in the extended organism.
Un processus ayant comme participants un organisme étendu et un médicament, à l'issue de laquelle une certaine dose du médicament est localisée dans l'organisme étendu.
This class should be re-classified under DRON:drug administration if it is made a subclass of process. See PDRO note in drug administration.
administration de dose
dose administration
"if patient is agitated"
a condition that is true if and only if some sign is observed in an individual.
condition indiquant la présence d'un signe
presence of sign condition
A time elapsed since previous dose condition that is true if and only if the time having elapsed is less than some duration.
less than some time elapsed since previous dose condition
A textual entity that allows the identification of a drug product.
Une entité textuelle qui fait référence à un type de médicament.
Note that this is a name of a drug product, not the name of an active ingredient contained in a drug product.
drug name
drug product identification
drug product name
nom de médicament
day of the week
jour de la semaine
"oral tablet" in "aspirin 80mg oral tablet"
An information content entity that specifies the dose form of a prescribed drug product.
drug dose form specification
An information content entity that specifies an excipient of a prescribed drug product.
drug excipient specification
"aspirin" in "aspirin 80mg oral tablet"
(since 80mg refers to the quantity of aspirin in the drug product, the drug active ingredient specification can also be interpreted as "aspirin 80 mg", i.e., "80 mg of aspirin")
An information content entity that specifies an active ingredient in a prescribed drug product.
drug active ingredient specification
Apo-Metoprolol
A drug product name given to a generic drug product by the pharmaceutical company that produces it
Un nom de médicament générique donné par l'entreprise pharmaceutique qui le produit.
generic drug product proprietary name
nom propriétaire d'un médicament générique
if it is before 12 PM on January 1st 2016
current time is before some instant condition
if it is after 12 PM on January 1st 2016
condition situant la période actuelle après un instant
current time is after some instant condition
if it is 12 PM on January 1st 2016
condition affirmant que l'instant présent est approximativement un instant donné
current time is approximately some instant condition
A time elapsed since previous dose condition that is true if and only if the time having elapsed is greater than some duration.
greater than some time elapsed since previous dose condition
A time elapsed since previous dose condition that is true if and only if the time having elapsed is equal to some duration.
exactly some time elapsed since previous dose condition
prescription drug product specification
"Aspirin 80mg oral tablet"
"Amiodarone 50mg/mL injectable solution"
An information content entity specifying a class of drug product intended to be administered in a drug administration.
drug product specification
spécification de médicament
moment de la journée
time of the day
mois de l'année
month of the year
A category value specification that specifies one day of the week.
day of the week category specification
A drug product information item that is about one excipient in a drug product.
Un élément d'information sur un médicament dénotant un de ses excipients.
drug excipient item
élément d'information d'excipient médicamenteuse
a condition describing the time elapsed since the first dose administration of some drug administration.
une condition de temps écoulé depuis la première administration de dose d'une certaine administration de médicament.
condition indiquant le temps écoulé depuis une première administration de dose
time elapsed since first dose condition
a condition describing the time elapsed since the previous dose administration of some drug administration.
une condition de temps écoulé depuis la dernière administration de dose d'une certaine administration de médicament.
condition indiquant le temps écoulé depuis une précédente administration de dose
time elapsed since previous dose condition
A current time condition where the current time is described in relation to a temporal instant.
une condition sur la période actuelle situant la période actuelle relativement à un instant donné.
instant of time condition
A health care facility whose function is to store, prepare, dispense, and monitor the usage of pharmaceutical drugs among patients in a given area or encountered in a given health care provider organization.
Un établissement de santé qui a pour fonction d'entreposer, préparer, distribuer et surveiller l'utilisation des médicaments parmi les patients d'une zone géographique donnée ou suivis dans une organisation de soin donnée.
pharmacy facility
établissement de pharmacologie
A textual entity that allows the identification of an excipient
Une entité textuelle qui permet l'identification d'un excipient
excipient name
a condition describing the number of doses administered in some drug administration.
number of doses in drug administration condition
A number of doses in drug administration condition that is true if and only if exactly some number of dose administrations have occured.
exactly some number of doses in drug administration condition
A pharmacist selecting a package of Aspirin 81mg oral tablets from the pharmacy inventory shelf.
A nurse selecting an ampoule of amiodarone 50mg/mL injectable solution from the ward's stock of drugs.
A doctor selecting a sample box of Spiriva 2.5mcg per puff Respimat Inhaler from the free sample drug stock cabinet.
A process where a health care provider physically selects a particular drug product as specified in a drug product specification.
Un processus dans lequel un fournisseur de soin sélectionne physiquement un médicament particulier comme indiqué sur une spécification de médicament.
Note that a doctor does not select a particular drug when prescribing unless they provide the actual drug with the prescription. They specify a drug product that is about the collection of drug products that are appropriate for a prescribed drug administration.
drug selection
sélection de médicament
A number of doses in drug administration condition that is true if and only if less than some number of dose administrations have occured.
less than some number of doses have occured condition
A number of doses in drug administration condition that is true if and only if more than some number of dose administrations have occured.
greater than some number of doses have occured condition
a condition that is true if and only if the time elapsed since some dispensing is greater than some duration.
greater than some time elapsed since the previous dispensing condition
A health care provider role where the service provided is that of identification, preparation, dispensing and monitoring of pharmaceutical drugs.
Un role de prestataire de soin qui fournit un service d'identification, de préparation, de distribution et de contrôle de médicaments.
pharmacist role
rôle de pharmacien
A nurse injecting 9mL of amiodarone 50mg/mL in 250 mL of D5 solution.
A patient mixing 4g of cholestyramine powder in a glass of orange juice.
A process in which a drug product is modified in order to render it more suitable for patient administration.
Un processus dans lequel un médicament est modifié de manière à le rendre plus approprié pour une administration au patient.
drug preparation
préparation de médicament
'it is the day after the end of the drug administration specified by "Prednisone 10mg PO die x 1 week"'
A condition that is true if and only if some process has ended
after some process condition
A condition that is true if and only if some drug administration has ended
after some drug administration condition
A condition that is true if and only if some dose administration has ended
after some dose administration condition
A condition that is true if and only if some surgery has ended
after some surgery condition
anatomical site of dose administration specification
An information content entity that specifies an anatomical entity which should be in contact with the drug product being administered during a dose administration.
for prescriptions, we only require the representation of 'condition' (e.g. what follows "PRN") and do not need to formalize 'statement'
site of administration specification
A normative specification that authorizes the dispensing of a drug product under certain conditions and usually specifies how much of the drug should be dispensed at a time.
drug dispensing specification
A Drug Identification Number (DIN) is a computer-generated eight digit number assigned by Health Canada to a drug product prior to being marketed in Canada. It uniquely identifies all drug products sold in a dosage form in Canada and is located on the label of prescription and over-the-counter drug products that have been evaluated and authorized for sale in Canada.
A DIN uniquely identifies the following product characteristics: manufacturer; product name; active ingredient(s); strength(s) of active ingredient(s); pharmaceutical form; route of administration.
DIN
http://www.hc-sc.gc.ca/dhp-mps/prodpharma/activit/fs-fi/dinfs_fd-eng.php
From wikipedia:
Any product defined as a drug under the Canadian Food and Drugs Act must have an associated Drug Identification Number (or DIN).
The Drug Identification Number (DIN) is the 8 digit number located on the label of prescription and over-the-counter drug products that have been evaluated by the Therapeutic Products Directorate (TPD) and approved for sale in Canada. The DIN is typically an eight digit number.
Once a drug has been approved, the Therapeutic Products Directorate issues a DIN which permits the manufacturer to market the drug in Canada. For drugs where there is minimal market history in Canada, there is a more stringent review and the drug is required to have a Notice of Compliance and a DIN in order to be marketed in Canada.
A DIN lets the user know that the product has undergone and passed a review of its formulation, labeling and instructions for use. A drug product sold in Canada without a DIN is not in compliance with Canadian law.
The DIN is also a tool to help in the follow-up of products on the market, recall of products, inspections, and quality monitoring. A drug product can be looked up via its DIN with the Health Canada's Drug Product Database (DPD) to find specific information of drugs approved by the Ministry.
Drug Identification Number
'1 metered dose actuation of nitroglycerine"
A natural number value specification that specifies a number of metered dose actuations.
metered dose actuation count value specification
A pharmacy technician providing a package of 30 Aspirin 81mg oral tablets to a patient.
A technician working at a hospital pharmacy sending 3 3mL ampoules of amiadorone 50 mg/mL injectable solution to a ward as part of a prescription for inpatient Harry Thymia.
A doctor providing a patient with a Respimat Inhaler device containing 60 puffs of Spiriva, 2.5mcg per puff.
A planned process in which a health care provider or person who is part of a health care organization provides a determinate quantity of a particular drug product for use in a particular patient.
Un processus planifié pendant lequel un professionnel de santé ou une personne faisant partie d'une organisation de santé fournit une quantité déterminée d'un médicament particulier à destination d'un patient particulier.
The person who is part of a health care organization may be e.g., a representative of an internet company which sends prescribed medication.
drug dispensing process
processus de distribution de médicament
e.g. start perfusion at 15cc/h. if MAP < 65 mmHg, then increase rate by 5cc/h every 5 minutes. If MAP=>65 mmHg, then decrease rate by 5cc/h every 5 minutes.
There are two rate of administration plan specifications here, one for each change specified:
'if MAP < 65 mmHg, then increase rate by 5cc/h every 5 minutes.' and
'If MAP>=65 mmHg, then decrease rate by 5cc/h every 5 minutes'
a plan specification that instructs how the rate at which a dose is administered should be changed based on certain conditions in order to maintain a certain equilibrium or targeted effect.
perfusion rate plan specification
rate of administration plan specification
A normative specification that directs the dosing in a drug administration.
Sig.
dosing instructions
posological instructions
prescribed dosing specification
normative directive information entity
A directive information entity that specifies how to realize a normative process
normative specification
The portion of a drug product that an organism is exposed to.
dose of drug product
A material entity that is the proper part of a drug product.
portion of drug product
supervising prescriber identification
rate of administration specification
rational number value specification
A category value specification that specifies one site of administration from a standardized list of possible sites.
site of administration category specification
mass per time unit
1
1
An information content entity that specifies the minimum and maximum quantities of drug product or active ingredient that can be administered as a dose in a dose administration.
dose range specification
Metoprolol tartrate
A scattered molecular aggregate with the role of active ingredient.
Un aggrégat de molécule dispersée avec le rôle d'ingrédient actif.
Should be moved to DRON
active ingredient aggregate
aggrégat d'ingrédient actif
John Smith being dispensed 60 Ativan 1mg oral tablets a 10th time as specified in the same prescription.
John Smith being dispensed in october 30x metoprolol 100 mg oral tablets after having being dispensed in september 30x metoprolol 100 mg oral tablets.
A drug dispensing process that follows an initial drug dispensing process, such that both processes are specified in the same drug prescription.
Un processus de distribution de médicament qui suit un processus de distribution initial, lorsque les deux processus sont indiqués dans la même prescription médicale.
drug renewal process
processus de renouvellement de médicament
The water in a solution of injectable amiodarone.
Un aggrégat de molécule dispersée ayant le rôle d'excipient.
scattered molecular aggregate with the role of excipient
Should be moved to DRON
aggrégat d'excipient
excipient aggregate
mass per time value specification
An information content entity that specifies how a dose is quantified in a dose administration.
This part of a prescription usually specifies a fixed amount (like '50 mg' or '500 mL'), but may instead specify a rate in some situations, e.g., in ongiong IV perfusions, where the total dose that will be administered in a single dose is unkown until the administration has ended. In either situation, the dose quantification specification is what enables the calculation of the quantity of active ingredient or drug product in the dose that is administered
dose quantification specification
A dose quantification specification that quantifies a dose by referring to the quantity of active ingredient administered in a dose administration.
active ingredient quantification specification
A dose quantification specification that quantifies a dose by referring to the quantity of drug product administered in a dose administration.
drug product quantification specification
8 mcg/min (of norepinephrine)
active ingredient mass delivery rate value specification
A condition whose truthfulness is a prerequisite for continuing a drug administration.
continuing condition
continuing drug administration condition
'if bronchitis'
'if January 1 2016'
A condition whose truthfulness is a prerequisite for starting a drug administration.
starting condition
starting drug administration condition
An information content entity that describes some relationships between some entities and whose truthfullness is a prerequisite for something
condition
'every 6 hours' in 'every 6 hours PRN'
A dosing condition that is true if and only if the amount of time that has elapsed since the previous dose is greater than some duration.
see note for maximum dosage condition. The same applies to this entitiy and 'greater than some time elapsed since previous dose condition'
minimum dosing interval condition
'maximum 4g/24h'
A dosing condition that is true if and only if the amount of drug product administered to a patient has not exceeded a certain amount per unit of time.
an instance of this condition would also be an instance of 'less than or equal to total dosage condition'. TODO: We need to be able to infer this without asserted multiple inheritance. An ideal solution would be introducing some sort of "role" for ICE in order to distinguish what a condition can be used for (what it's truthfulness is a prerequisite for) from it's logical construction (what information it is composed of). -RT
maximum dosage condition
'less than 3 doses have been taken today'
'8 hours have elapsed since the previous dose'
'it is wednesday'
A condition whose truthfulness is a prerequisite for the taking of a dose.
dosing condition
"1 dispensing per month"
"12 dispensings per year"
A value specification that specifies the frequency of a drug dispensing.
Une spécification de valeur de fréquence indiquant la fréquence d'un processus de distribution de médicament.
Elle a une unité de la forme "distribution de médicament par unité de temps".
Has unit label of the form 'drug dispensings per unit time'.
nb. "#30 renew x12", has as part a drug dispensing count specification, not a drug dispensing frequency specification.
This is because the dispensing process is not specified to occur 'per unit of time'; it is specified to occur 'a number of times'.
drug dispensing frequency specification
spécification de fréquence de distribution de médicament
"12 dispensings"
A natural number value specification that specifies a number of dispensing processes.
Une spécification de valeur entière qui indique un nombre de distributions de médicaments.
"Dispense 30 tabs, not renewable" -> 1 dispensing
"Dispense 30 tabs, dispense 12 times" -> 12 dispensings
"Dispense 30 tabs, repeatable 12 times" ->13 dispensings
"Dispense 30 tabs, renew 12 times" -> 13 dispensings
"Dispense 30 tabs every month for one year" -> 12 dispensings
drug dispensing count specification
spécification de nombre de distributions de médicaments
John Smith being dispensed 60x Ativan 1mg oral tablets for the first time
A drug dispensing process that is the first time the patient is being provided with a particular drug following a particular prescription.
Un processus de distribution de médicament tel que ce médicament n'a jamais été fourni au patient auparavant sur la base de cette prescription particulière.
initial drug dispensing process
processus de distribution de médicament initiale
drug dose administration specification
"1 tablet by mouth"
"Mix 4g powder with 1 cup of water and drink slowly"
"mix 450mg in 250mL of D5% solution, then administrate IV over 12 hours"
"nebulize 2.5mg and administrate inhaled over 5-15 minutes"
An action specification that describes a dose administration.
Une spécification d'action qui décrit une administration de dose médicamenteuse.
dose administration specification
spécification d'administration de dose
"3 pregnancies to term"
A scalar value specification where the numeral is a natural number.
Une spécification de valeur scalaire où le nombre est un entier naturel.
natural number value specification
spécification de valeur entière
A scalar value specification that specifies the frequency of a process.
Une spécification de valeur scalaire indiquant la fréquence d'un processus.
frequency value specification
spécification de valeur de fréquence
A prophylaxis composed of one or more dose administrations.
Une prophylaxie composée d'une ou plusieurs administrations de doses.
drug prophylaxis
prophylaxie médicamenteuse
A process in which the administration of a drug product as prescribed is hypothesized to achieve some health care objective.
Un processus pendant lequel une ou plusieurs administrations de dose est supposée remplir un certain objectif de santé.
Note that we do not consider all drug administrations to be treatments, as in the case of prophylaxis.
A health care objective could concern e.g., treatment, prophylaxis and contraception. We leave open the question of whether it should include objectives such as physician-assisted suicide.
need to align with DRON
administration de médicament
prescribed drug administration
"The alleviation of a symptomatic cough"
"The prevention of malaria"
"The diagnosis of what ails John Smith"
An objective specification that specifies the objective of a health care process.
Une spécification d'objectif d'un processus de soin ou d'une de ses parties.
health care objective specification
spécification d'objectif de santé
'30 tablets' in 'dispense 30 tablets'
An information content entity that describes the amount of a drug product to dispense in a single drug dispensing process.
Une entité informationnelle qui indique la quantité de médicament à distribuer pendant un processus de distribution unique.
drug dispensing quantity specification
drug dispensing amount specification
spécification de la quantité de médicament à distribuer
Une spécification d'objectif de santé de traitement.
spécification d'objectif de traitement
treatment objective specification
Une spécification d'objectif de santé prophylactique.
prophylaxis objective specification
spécification d'objectif prophylactique
Une spécification d'objectif de santé diagnostique.
diagnostic objective specification
spécification d'objectif diagnostique
A value specification that specifies the volume of some thing.
Une spécification de valeur qui indique un volume.
spécification de valeur de volume
volume value specification
prescribed drug administration specification
"take Aspirin 81 mg oral tablet, 1 tablet once daily by mouth, start today, Dispense 30 tabs every month for one year"
A normative specification that specifies how to perform a drug administration.
It specifies:
- The drug product
- The posology
- The condition(s) for starting
Une entité informationnelle directive indiquant l'administration d'un médicament.
Elle indique :
- le médicament.
- le(s) condition(s) de distribution du médicament.
- la quantité de médicament à distribuer.
- le(s) condition(s) de début d'administration du médicament.
- le(s) condition(s) de continuation d'administration du médicament
- le(s) condition(s) d'administration d'une dose
- comment administrer une dose, ce qui inclut:
-- Toute préparation du médicament requise avant l'administration.
-- La dose à administrer.
-- Le mode d'administration
-- Toute particularité dans la manière d'administrer le médicament.
drug administration specification
"10 capsules"
"1 patch"
"1/2 tablet"
A value specification that specifies an amount of drug product objects.
Une spécification de valeur entière qui indique un nombre de médicaments
The unit label here is a 'discrete drug object' (capsules, tablets, patches, etc.)
drug product object count specification
spécification de nombre de médicaments
A volume value specification where the volume specified is that of a drug product.
Une spécification de valeur de volume indiquant le volume d'un médicament.
drug product volume value specification
spécification de valeur de volume de médicament
A mass value specification that specifies the mass of a drug product.
Une spécification de valeur de masse qui indique la masse d'un médicament.
drug product mass value specification
spécification de valeur de masse de médicament
e=entity
r=relationship
"Unicorns exist"
e1: a single horned animal
e2: an equestrian animal
e3: spatial region of universe
r1: e1 is a e2
r2: e1 located in e3
"You have chest pain"
e1: chest pain
e2: patient referred to by 'you'
r1: e2 experiencing e1
"The traffic light is green"
"You have not taken a dose in the last 6 hours"
"less than 12 dispensings have occurred"
An information content entity that describes some relationships between some entities and is intended to be evaluated as true or false.
statement
énoncé
true
"1 hour"
"15 minutes"
"30 seconds"
A scalar value specification that specifies a duration of time.
Une spécification de valeur scalaire qui indique une durée de temps.
spécification de durée temporelle
temporal duration specification
"4 dose administrations per day"
"2 dose administrations per hour"
A value specification of the frequency of a dose administration.
Une spécification de valeur de fréquence indiquant la fréquence d'un processus d'administration de dose.
Elle a une unité de la forme "administrations de dose par unité de temps".
Has a unit label of the form 'dose administrations per unit time'.
dose administration frequency specification
spécification de fréquence d'administration de dose
'5000 units' (of fragmin)
'10 units' (of insulin)
A scalar value specification that specifies the value of an active ingredient aggregate biological activity.
Une spécification de valeur scalaire qui indique la valeur d'activité biologique d'un aggrégat d'ingrédient actif.
pharmacological unit value specification
spécification de valeur d'unité pharmacologique
A scalar value specification that specifies the quantity of an element or compound with uniform disposition.
spécification de quantité de substance
substance quantity value specification
'50mL per hour'
A scalar value specification whose unit label is a volumetric rate unit.
Une spécification de valeur scalaire dont l'unité est une unité de rythme.
spécification de valeur de rythme
volumetric flow rate value specification
'80cc per hour' (of NS, which is NaCl + water)
A rate value specification that specifies the rate at which a drug product is administered during a dose administration.
Une spécification de valeur de rythme qui indique le rythme auquel un médicament est administré pendant une administration de dose.
drug product volumetric flow rate value specification
spécification de valeur de rythme de médicament
A substance value specification where the substance is an active ingredient aggregate.
Une spécification de quantité de substance où la substance est un aggrégat d'ingrédient actif.
active ingredient molar value specification
spécification de valeur molaire d'ingrédient actif
pharmacological international unit
the "units" in 10 units of insulin
A measurement unit label for the amount of a substance based on a specified biological activity or effect of that substance.
Un label d'unité de mesure pour la quantité de substance fondé sur une activité biologique spécifiée ou sur un effet de cette substance.
pharmacological unit
unité pharmacologique
"3 dose administration"
"1 dose administration"
A natural number value specification that specifies a number of dose administrations.
Une spécification de valeur entière qui indique un nombre d'administrations de doses.
dose administration count specification
spécification de nombre d'administrations de doses
"You have chest pain"
"You are having trouble breathing"
a condition that is true if and only if some symptom is observed in an individual.
condition indiquant la présence d'un symptôme
presence of symptom condition
"if patient is asleep"
a condition that is true if and only if an individual is observed as being in some state of consciousness.
condition indiquant un état de concience
state of consciousness condition
A condition that describes the current time period relative to some other time period
Une condition situant la période actuelle relativement à une autre période.
current time condition
"2 weeks have elapsed since returning from travel"
"14 days have elapsed since the start of treatment"
"6 hours have elapsed since the previous dose"
a condition describing the amount of time that has elapsed since an event.
une condition décrivant le temps écoulé depuis un évènement.
condition de temps écoulé
time elapsed condition
a condition describing the number of dose administrations that have occured over a given duration of time.
une condition décrivant le nombre d'administration de doses qui se sont produites pendant une certaine durée de temps.
condition décrivant le nombre de doses par unité de temps
number of doses per unit time condition
"less than 3 dose administrations have occured in the last 15 minutes"
A number of doses condition that is true if and only if the number of dose administrations having occured is less than a specified number.
une condition décrivant le nombre de doses par unité de temps comme étant inférieur à un certain nombre d'administration de doses.
condition indiquant que le nombre de doses par unité de temps est inférieur à
less than some number of doses per unit time condition
"greater than 1 dose has occured in the last 6 hours"
A number of doses condition that is true if and only if the number of dose administrations having occured is greater than a specified number.
une condition décrivant le nombre de doses par unité de temps comme étant supérieur à un certain nombre d'administration de doses.
condition indiquant que le nombre de doses par unité de temps est supérieur à
greater than some number of doses per unit time condition
"1 dose administration has occured in the last day"
A number of doses condition that is true if and only if a specified number of dose administrations have occured.
une condition décrivant le nombre de doses par unité de temps comme étant égal à un certain nombre d'administration de doses.
condition indiquant que le nombre de doses par unité de temps est égal à
exactly some number of doses per unit time condition
A condition describing the number of dispensings that have occurred as directed by a certain prescription.
Une condition d'une prescription décrivant un nombre de distributions passées.
condition indiquant un nombre de distributions passées
number of dispensings condition
"if less than one dispensing has occurred"
A number of dispensings condition that is true if and only if the number of dispensings having occurred is less than a specified number.
Un condition de nombre de distributions indiquant qu'un nombre de distributions passées est plus petit qu'un certain nombre.
condition indiquant qu'un nombre de distributions passées est plus petit qu'un certain nombre
less than some number of dispensings condition
"10 units of insulin have been administered in the last hour"
a condition describing the amount of drug product or active ingredient that has been administered in a given duration of time.
une condition décrivant la quantité de médicament ou d'ingrédient actif qui a été administrée pendant une certaine période de temps.
condition de dosage total
total dosage condition
A total dosage condition that is true if and only if the total dosage administered is less or equal to a specified amount.
une condition de dosage total où le dosage total administré est inférieur ou égal à une certaine quantité.
condition de dosage total inférieur ou égal à une certaine quantité
less than or equal to total dosage condition
A total dosage condition that is true if and only if the total dosage administered is greater than a specified amount.
une condition de dosage total où le dosage total administré est supérieur à une certaine quantité.
condition de dosage total supérieur à une certaine quantité
greater than total dosage condition
A total dosage condition that is true if and only if the total dosage administered is equal to a specified amount.
une condition de dosage total où le dosage total administré est égal à une certaine quantité.
condition de dosage total égal à une certaine quantité
equal to total dosage condition
"6 hours have elapsed since the previous dose of metoprolol 50mg oral tablets"
a condition describing the time elapsed since a dose administration.
condition indiquant le temps écoulé depuis une administration de dose
time elapsed since dose condition
A category value specification that specifies one route of administration from a standardized list of possible routes.
route of administration category specification
spécification de la catégorie de la voie d'administration
médicament non-générique
non-generic drug product
generic drug product
médicament générique
International Nonproprietary Name
An active ingredient name that is an International Nonproprietary Name.
Un nom d'ingrédient actif qui est un International Nonproprietary Name.
We may require the addition of an INNM class in the future.
http://www.who.int/medicines/services/inn/innguidance/en/
"INN are selected in principle only for single, well-defined substances that can be unequivocally characterized by a chemical name (or formula). It is the policy of the INN programme not to select names for mixtures of substances, while substances that are not fully characterized are included in the INN system in exceptional cases only. INN are not selected for herbal substances (vegetable drugs) or for homoeopathic products. It is also the policy of the INN programme not to select names for those substances that have a long history of use for medical purposes under well-established names such as those of alkaloids (e.g. morphine, codeine), or trivial chemical names (e.g. acetic acid).
An INN is usually designated for the active part of the molecule only, to avoid the multiplication of entries in cases where several salts, esters, etc. are actually used. In such cases, the user of the INN has to create a modified INN (INNM) himself ; mepyramine maleate (a salt of mepyramine with maleic acid) is an example of an INNM. When the creation of an INNM would require the use of a long or inconvenient name for the radical part of the INNM, the INN programme will select a short name for such a radical (for example, mesilate for methanesulfonate)."
INN name
nom INN
A textual entity that allows the identification of an active ingredient
Une entité textuelle qui permet l'identification d'un ingrédient actif.
active ingredient name
nom d'ingrédient actif
The configuration of a tablet after it has been crushed and dissolved in a glass of water.
The configuration of a tablet before it has been administered
La configuration d'un médicament juste avant qu'il soit administré.
The configuration of a drug product just before it is administered.
This configuration may have been the result of some drug preparation.
administration dose form
forme de la dose d'administration
La configuration d'un médicament à la fin d'un processus de production pharmaceutique.
The configuration of a drug product at the end of a pharmaceutical production process.
This needs to be eventually distinguished with drug product vehicles.
drug product dose form
forme de dose médicamenteuse
The active ingredient aggregate strength in the active ingredient aggregate of 10 units of Humalog insulin
A quality inhering in an active ingredient aggregate by virtue of the magnitude of a standardized biological effect of that active ingredient.
Une qualité inhérent dans un aggrégat d'ingrédient actif en vertu d'une magnitude d'effet biologique standardisé de cet ingrédient actif.
This is to represent the qualities that inhere in drugs measured by a standardized pharmacological unit.
E.g.
1 unit of heparin is the quantity required to keep 1 mL of cat's blood fluid for 24 hours at 0°C.
1 unit of insulin is the amount required to reduce the concentration of blood glucose in a fasting rabbit to 45 mg/dl (2.5 mmol/L).
active ingredient aggregate biological activity
activité biologique d'un aggrégat d'ingrédient actif
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