format-version: 1.0 date: 01:30:2008 16:09 saved-by: gwg auto-generated-by: DAG-Edit 1.419 rev 3 default-namespace: worm_development remark: Version: 1.04 remark: Date: 01/25/08 remark: Editors: Wen J. Chen, WormBase, Caltech remark: This DAG flat files is created for Lifestage system used in WormBase [Term] id: WBls:0000041 name: adult is_a: WBls:0000022 ! postembryonic [Term] id: WBls:0000001 name: C. elegans Development DAG [Term] id: WBls:0000002 name: all stages def: "All C. elegans development stages\, including embryo\, larva and adult stage." [wb:wjc] is_a: WBls:0000001 ! C. elegans Development DAG [Term] id: WBls:0000003 name: embryo def: "The whole period of embryogenesis\, from the formation of an egg till its hatch. " [wb:wjc] is_a: WBls:0000002 ! all stages [Term] id: WBls:0000004 name: proliferating embryo def: "0-350min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 560 cells. From start of first cleavage till cleavage is over." [wb:wjc] is_a: WBls:0000003 ! embryo [Term] id: WBls:0000005 name: blastula embryo def: "0-100min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 28 cells. From first cleavage till the start of gastrulation." [wb:wjc] is_a: WBls:0000004 ! proliferating embryo [Term] id: WBls:0000006 name: 1-cell embryo def: "Also called zygote. -50min till 0min of first cleavage at 20 Centigrade. Contains 1 cell." [wb:wjc] is_a: WBls:0000005 ! blastula embryo [Term] id: WBls:0000007 name: 2-cell embryo def: "0-20min after first cleavage at 20 Centigrade. Contains 2 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo [Term] id: WBls:0000008 name: 4-cell embryo def: "20-40min after first cleavage at 20 Centigrade. Contains 4 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo [Term] id: WBls:00000071 name: 8-cell embryo def: "~50 min after first cleavage at 20 Centigrade. Contains 8 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo [Term] id: WBls:00000072 name: 12-cell embryo def: "~55 min after first cleavage at 20 Centigrade. Contains 12 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo [Term] id: WBls:0000009 name: 28-cell embryo def: "100-105min after first cleaveage at 20 Centigrade. Contains 28 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo [Term] id: WBls:0000010 name: gastrulating embryo def: "100-290min after first cleavage at 20 Centigrade. Proliferate from 28 cells to 421 cells. Referring to the whole period of gastrulation." [wb:wjc] is_a: WBls:0000004 ! proliferating embryo [Term] id: WBls:0000011 name: 51-cell embryo def: "120-135min after first cleavage at 20 Centigrade. Contains 51 cells." [wb:wjc] is_a: WBls:0000010 ! gastrulating embryo [Term] id: WBls:0000012 name: 88-cell embryo def: "145-150min after first cleavage at 20 Centigrade. Contains 88 cells." [wb:wjc] is_a: WBls:0000010 ! gastrulating embryo [Term] id: WBls:0000013 name: enclosing embryo def: "290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastulation and is enclosing." [wb:wjc] is_a: WBls:0000004 ! proliferating embryo [Term] id: WBls:0000014 name: late cleavage stage embryo def: "210-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage before the fast cleavage of cells finishes. " [wb:wjc] is_a: WBls:0000004 ! proliferating embryo [Term] id: WBls:0000015 name: elongating embryo def: "350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells\, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation till elongation is over." [wb:wjc] is_a: WBls:0000003 ! embryo [Term] id: WBls:0000016 name: bean embryo def: "350-390min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells\, with some new cells generated and some cells go through programmed cell death. Emrbyo elongation started but have not formed comma shape yet. The shape of embryo looks like a lima bean. A stage right before comma embryo. Also called lima embryo or lima bean stage." [wb:wjc] is_a: WBls:0000015 ! elongating embryo [Term] id: WBls:0000017 name: comma embryo def: "390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells\, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo. " [wb:wjc] is_a: WBls:0000015 ! elongating embryo [Term] id: WBls:0000018 name: 1.5-fold embryo def: "420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells\, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo." [wb:wjc] is_a: WBls:0000015 ! elongating embryo [Term] id: WBls:0000019 name: 2-fold embryo def: "460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells\, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo." [wb:wjc] is_a: WBls:0000015 ! elongating embryo [Term] id: WBls:0000020 name: 3-fold embryo def: "520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells\, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage." [wb:wjc] is_a: WBls:0000015 ! elongating embryo [Term] id: WBls:0000021 name: fully-elongated embryo def: "620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells\, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo\, late embryo or morphogenetic embryo." [wb:wjc] is_a: WBls:0000003 ! embryo [Term] id: WBls:0000022 name: postembryonic def: "The stage after hatch till death." [wb:wjc] is_a: WBls:0000002 ! all stages [Term] id: WBls:0000023 name: larva def: "From the time after hatch till becomes adult." [wb:wjc] is_a: WBls:0000022 ! postembryonic [Term] id: WBls:0000024 name: L1 larva def: "The first stage larva. At 25 Centigrade\, it ranges 14-25.5 hours after fertilization\, 0-11.5 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva [Term] id: WBls:0000025 name: L1-L2 lethargus def: "The stage during L1-L2 molt when an animal becomes lethargic\, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000026 ! L1-L2 molt [Term] id: WBls:0000026 name: L1-L2 molt def: "The stage when an animal shifts from L1 larva to L2 larva. It includes the synthesis of new cuticle\, cease of phrayngeal pumping during a lethargus stage\, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000024 ! L1 larva [Term] id: WBls:0000027 name: L2 larva def: "The second stage larva. At 25 Centigrade\, it ranges 25.5-32.5 hours after fertilization\, 11.5-18.5 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva [Term] id: WBls:0000028 name: L2-L3 lethargus def: "The stage during L2-L3 molt when an animal becomes lethargic\, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000029 ! L2-L3 molt [Term] id: WBls:0000029 name: L2-L3 molt def: "The stage when an animal shifts from L2 larva to L3 larva. It includes the synthesis of new cuticle\, cease of phrayngeal pumping during a lethargus stage\, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000027 ! L2 larva [Term] id: WBls:0000030 name: L2d-dauer lethargus def: "The stage during L2d-dauer molt when an animal becomes lethargic\, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000031 ! L2d-dauer molt [Term] id: WBls:0000031 name: L2d-dauer molt def: "The stage when an animal shifts from L2d larva to dauer larva. It includes the synthesis of new cuticle\, cease of phrayngeal pumping during a lethargus stage\, and the shed off of old cuticle. " [wb:wjc] is_a: WBls:0000046 ! L2d larva [Term] id: WBls:0000032 name: dauer larva def: "A third stage larva specialized for dispersal and long term survival. " [ISBN:0-87969-433-5] is_a: WBls:0000023 ! larva [Term] id: WBls:0000033 name: postdauer-L4 lethargus def: "The stage during postdauer-L4 molt when an animal becomes lethargic\, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000034 ! postdauer-L4 molt [Term] id: WBls:0000034 name: postdauer-L4 molt def: "The stage when an animal shifts from post dauer stage to L4 larva. It includes the synthesis of new cuticle\, cease of phrayngeal pumping during a lethargus stage\, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000052 ! post dauer stage [Term] id: WBls:0000035 name: L3 larva def: "The third stage larva. At 25 Centigrade\, it ranges 32.5-40 hours after fertilization\, 18.5-26 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva [Term] id: WBls:0000036 name: L3-L4 lethargus def: "The stage during L3-L4 molt when an animal becomes lethargic\, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000037 ! L3-L4 molt [Term] id: WBls:0000037 name: L3-L4 molt def: "The stage when an animal shifts from L3 larva to L4 larva. It includes the synthesis of new cuticle\, cease of phrayngeal pumping during a lethargus stage\, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000035 ! L3 larva [Term] id: WBls:0000038 name: L4 larva def: "The fourth stage larva. At 25 Centigrade\, it ranges 40-49.5 hours after fertilization\, 26-35.5 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva [Term] id: WBls:0000073 name: L4 larva male def: "The fourth stage larva male. At 25 Centigrade\, it ranges 40-49.5 hours after fertilization\, 26-35.5 hours after hatch." [wb:wjc] is_a: WBls:0000038 ! L4 larva [Term] id: WBls:0000039 name: L4-adult lethargus def: "The stage during L4-adult molt when an animal becomes lethargic\, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000040 ! L4-adult molt [Term] id: WBls:0000040 name: L4-adult molt def: "The stage when an animal shifts from L4 larva to adult. It includes the synthesis of new cuticle\, cease of phrayngeal pumping during a lethargus stage\, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000038 ! L4 larva [Term] id: WBls:0000042 name: L1-L2 ecdysis def: "The stage during L1-L2 molt\, after the brief lethargus period\, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000026 ! L1-L2 molt [Term] id: WBls:0000043 name: L1-L2d molt def: "The stage when an animal shifts from L1 larva to L2d larva. It includes the synthesis of new cuticle\, cease of phrayngeal pumping during a lethargus stage\, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000024 ! L1 larva [Term] id: WBls:0000044 name: L1-L2d lethargus def: "The stage during L1-L2d molt when an animal becomes lethargic\, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000043 ! L1-L2d molt [Term] id: WBls:0000045 name: L1-L2d ecdysis def: "The stage during L1-L2d molt\, after the brief lethargus period\, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000043 ! L1-L2d molt [Term] id: WBls:0000046 name: L2d larva def: "A special second stage larva with altered physiology and developmental potential that leads to formation of dauer larva. At 25 Centigrade\, it ranges 25.5-32.5 hours after fertilization\, 11.5-18.5 hours after hatch." [ISBN:0-87969-433-5] is_a: WBls:0000023 ! larva [Term] id: WBls:0000047 name: L2-L3 ecdysis def: "The stage during L2-L3 molt\, after the brief lethargus period\, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000029 ! L2-L3 molt [Term] id: WBls:0000048 name: L2d-dauer ecdysis def: "The stage during L2d-dauer molt\, after the brief lethargus period\, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000031 ! L2d-dauer molt [Term] id: WBls:0000049 name: L3-L4 ecdysis def: "The stage during L3-L4 molt\, after the brief lethargus period\, when an animal sheds off old cuticle. " [wb:wjc] is_a: WBls:0000037 ! L3-L4 molt [Term] id: WBls:0000050 name: L4-adult ecdysis def: "The stage during L4-adult molt\, after the brief lethargus period\, when an animal shed off old cuticle. " [wb:wjc] is_a: WBls:0000040 ! L4-adult molt [Term] id: WBls:0000051 name: postdauer-L4 ecdysis def: "The stage during postdauer-L4 molt\, after the brief lethargus period\, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000034 ! postdauer-L4 molt [Term] id: WBls:0000052 name: post dauer stage def: "The stage right after an animal recovered from dauer but has not started transformation to L4 larva yet. " [wb:wjc] is_a: WBls:0000023 ! larva [Term] id: WBls:0000053 name: L2d-L3 molt def: "The stage when an animal shifts from L2d larva to L3 larva. It includes the synthesis of new cuticle\, cease of phrayngeal pumping during a lethargus stage\, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000046 ! L2d larva [Term] id: WBls:0000054 name: L2d-L3 lethargus def: "The stage during L2d-L3 molt when an animal becomes lethargic\, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000053 ! L2d-L3 molt [Term] id: WBls:0000055 name: L2d-L3 ecdysis def: "The stage during L2d-L3 molt\, after the brief lethargus period\, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000053 ! L2d-L3 molt [Term] id: WBls:0000056 name: adult male def: "The stage after an male animal is fully-developed and reaches maturity." [wb:wjc] is_a: WBls:0000041 ! adult [Term] id: WBls:0000057 name: adult hermaphrodite def: "The stage after an hermaphrodite animal is fully-developed and reaches maturity." [wb:wjc] is_a: WBls:0000041 ! adult [Term] id: WBls:0000058 name: pre-reproductive stage adult hermaphrodite def: "Very young adult hermaphrodites that do not have eggs in the uterus yet. At 20 Centigrade\: 0 - 13 hours after L4-adult molt. 3 days after first cleaveage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000060 name: reproductive stage adult hermaphrodite def: "Adult hermaphrodites continuously laying fertilized eggs. hermaphrodite in egg laying stages--ususally up to 4/5 days after L4-adult molt at Centigrade. From the first fertilized egg is laid\, til all sperms are used. At 20 Centigrade\: 13 hours after L4-adult molt until about 5.4 days after the L4-adult molt. 3-8.4 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000061 name: oocyte-laying stage adult hermaphrodite def: "When egg-laying is still going on but intermittent and during which a significant number of oocytes are laid. Included in reproductive stage adult hermaphrodite." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000062 name: post-reproductive stage adult hermaphrodite def: "Adult hermaphrodites that contain no more sperm\, thus stop egg-laying\, but still alive. At 20 Centigrade\: 5.4 days after L4-adult molt until the death. 8.4 - 13.2 (average wild type life span) days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000063 name: newly molted young adult hermaphrodite def: "At 20 Centigrade\: 0-24 hours after L4-adult molt." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000064 name: 1-day post-L4 adult hermaphrodite def: "At 20 Centigrade\: 24-48 hours after L4-adult molt. 4-5 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000065 name: 2-days post-L4 adult hermaphrodite def: "At 20 Centigrade\: 48-72 hours after L4-adult molt. 5-6 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000066 name: 3-days post-L4 adult hermaphrodite def: "At 20 Centigrade\: 72-96 hours after L4-adult molt. 6-7 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000067 name: 4-days post-L4 adult hermaphrodite def: "At 20 Centigrade\: 96-120 hours after L4-adult molt. 7-8 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000068 name: 5-days post-L4 adult hermaphrodite def: "At 20 Centigrade\: 5-6 days after L4-adult molt. 8-9 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000069 name: 4-7 days post-L4 adult hermaphrodite def: "At 20 Centigrade\: 4-7 days after L4-adult molt. 7-10 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000070 name: 7-10 days post-L4 adult hermaphrodite def: "At 20 Centigrade\: 7-10 days after L4-adult molt. 10-13 days after first cleavage. Usually this is the end of wild type C. elegans life span." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Typedef] id: is_a name: is a