format-version: 1.2 date: 27:11:2013 05:55 saved-by: danielaraciti auto-generated-by: OBO-Edit 2.2-rc1 default-namespace: worm_development remark: Version: 1.04 remark: Editors: Wen J. Chen & Daniela Raciti, WormBase, Caltech [Term] id: WBls:0000001 name: C. elegans Development is_a: WBls:0000075 ! Nematoda Life Stage [Term] id: WBls:0000002 name: all stages Ce def: "All C. elegans development stages, including embryo, larva and adult stage." [wb:wjc] is_a: WBls:0000001 ! C. elegans Development [Term] id: WBls:0000003 name: embryo Ce def: "The whole period of embryogenesis, from the formation of an egg till its hatch." [wb:wjc] is_a: WBls:0000002 ! all stages Ce [Term] id: WBls:0000004 name: proliferating embryo Ce def: "0-350min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 560 cells. From start of first cleavage till cleavage is over." [wb:wjc] is_a: WBls:0000003 ! embryo Ce [Term] id: WBls:0000005 name: blastula embryo Ce def: "0-100min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 28 cells. From first cleavage till the start of gastrulation." [wb:wjc] is_a: WBls:0000004 ! proliferating embryo Ce [Term] id: WBls:0000006 name: 1-cell embryo Ce def: "Also called zygote. -50min till 0min of first cleavage at 20 Centigrade. Contains 1 cell." [wb:wjc] is_a: WBls:0000005 ! blastula embryo Ce [Term] id: WBls:0000007 name: 2-cell embryo Ce def: "0-20min after first cleavage at 20 Centigrade. Contains 2 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo Ce relationship: preceded_by WBls:0000006 ! 1-cell embryo Ce [Term] id: WBls:0000008 name: 4-cell embryo Ce def: "20-40min after first cleavage at 20 Centigrade. Contains 4 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo Ce relationship: preceded_by WBls:0000007 ! 2-cell embryo Ce [Term] id: WBls:0000009 name: 28-cell embryo Ce def: "100-105 min after first cleaveage at 20 Centigrade. Contains 28 cells." [wb:wjc] is_a: WBls:0000010 ! gastrulating embryo Ce [Term] id: WBls:0000010 name: gastrulating embryo Ce def: "100-290min after first cleavage at 20 Centigrade. Proliferate from 28 cells to 421 cells. Referring to the whole period of gastrulation." [wb:wjc] is_a: WBls:0000004 ! proliferating embryo Ce relationship: preceded_by WBls:0000005 ! blastula embryo Ce [Term] id: WBls:0000011 name: 51-cell embryo Ce def: "120-135 min after first cleavage at 20 Centigrade. Contains 51 cells." [wb:wjc] is_a: WBls:0000010 ! gastrulating embryo Ce relationship: preceded_by WBls:0000086 ! 44-cell embryo Ce [Term] id: WBls:0000012 name: 88-cell embryo Ce def: "145-150 min after first cleavage at 20 Centigrade. Contains 88 cells." [wb:wjc] is_a: WBls:0000010 ! gastrulating embryo Ce relationship: preceded_by WBls:0000088 ! 86-cell embryo Ce [Term] id: WBls:0000013 name: enclosing embryo Ce def: "290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastulation and is enclosing." [wb:wjc] is_a: WBls:0000014 ! late cleavage stage embryo Ce relationship: preceded_by WBls:0000010 ! gastrulating embryo Ce relationship: preceded_by WBls:0000014 ! late cleavage stage embryo Ce [Term] id: WBls:0000014 name: late cleavage stage embryo Ce def: "210-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage before the fast cleavage of cells finishes. " [wb:wjc] is_a: WBls:0000004 ! proliferating embryo Ce relationship: preceded_by WBls:0000010 ! gastrulating embryo Ce [Term] id: WBls:0000015 name: elongating embryo Ce def: "350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation till elongation is over." [wb:wjc] is_a: WBls:0000003 ! embryo Ce relationship: preceded_by WBls:0000004 ! proliferating embryo Ce relationship: preceded_by WBls:0000010 ! gastrulating embryo Ce [Term] id: WBls:0000016 name: bean embryo Ce def: "350-390min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. Emrbyo elongation started but have not formed comma shape yet. The shape of embryo looks like a lima bean. A stage right before comma embryo. Also called lima embryo or lima bean stage." [wb:wjc] is_a: WBls:0000015 ! elongating embryo Ce relationship: preceded_by WBls:0000013 ! enclosing embryo Ce relationship: preceded_by WBls:0000014 ! late cleavage stage embryo Ce [Term] id: WBls:0000017 name: comma embryo Ce def: "390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo." [wb:wjc] is_a: WBls:0000015 ! elongating embryo Ce relationship: preceded_by WBls:0000016 ! bean embryo Ce [Term] id: WBls:0000018 name: 1.5-fold embryo Ce def: "420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo." [wb:wjc] is_a: WBls:0000015 ! elongating embryo Ce relationship: preceded_by WBls:0000017 ! comma embryo Ce [Term] id: WBls:0000019 name: 2-fold embryo Ce def: "460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo." [wb:wjc] is_a: WBls:0000015 ! elongating embryo Ce relationship: preceded_by WBls:0000018 ! 1.5-fold embryo Ce [Term] id: WBls:0000020 name: 3-fold embryo Ce def: "520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage." [wb:wjc] is_a: WBls:0000015 ! elongating embryo Ce relationship: preceded_by WBls:0000019 ! 2-fold embryo Ce [Term] id: WBls:0000021 name: fully-elongated embryo Ce def: "620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo." [wb:wjc] is_a: WBls:0000003 ! embryo Ce relationship: preceded_by WBls:0000015 ! elongating embryo Ce relationship: preceded_by WBls:0000020 ! 3-fold embryo Ce [Term] id: WBls:0000022 name: postembryonic Ce def: "The stage after hatch till death." [wb:wjc] is_a: WBls:0000002 ! all stages Ce relationship: preceded_by WBls:0000003 ! embryo Ce [Term] id: WBls:0000023 name: larva Ce def: "From the time after hatch till becomes adult." [wb:wjc] is_a: WBls:0000022 ! postembryonic Ce relationship: preceded_by WBls:0000003 ! embryo Ce [Term] id: WBls:0000024 name: L1 larva Ce def: "The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000003 ! embryo Ce [Term] id: WBls:0000025 name: L1-L2 lethargus Ce def: "The stage during L1-L2 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old." [wb:wjc] is_a: WBls:0000026 ! L1-L2 molt Ce [Term] id: WBls:0000026 name: L1-L2 molt Ce def: "The stage when an animal shifts from L1 larva to L2 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000024 ! L1 larva Ce [Term] id: WBls:0000027 name: L2 larva Ce def: "The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000024 ! L1 larva Ce relationship: preceded_by WBls:0000026 ! L1-L2 molt Ce [Term] id: WBls:0000028 name: L2-L3 lethargus Ce def: "The stage during L2-L3 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old." [wb:wjc] is_a: WBls:0000029 ! L2-L3 molt Ce [Term] id: WBls:0000029 name: L2-L3 molt Ce def: "The stage when an animal shifts from L2 larva to L3 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000027 ! L2 larva Ce [Term] id: WBls:0000030 name: L2d-dauer lethargus Ce def: "The stage during L2d-dauer molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old." [wb:wjc] is_a: WBls:0000031 ! L2d-dauer molt Ce [Term] id: WBls:0000031 name: L2d-dauer molt Ce def: "The stage when an animal shifts from L2d larva to dauer larva. It includes the synthesis of new cuticle, cease of pharyngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000023 ! larva Ce [Term] id: WBls:0000032 name: dauer larva Ce def: "A third stage larva specialized for dispersal and long term survival." [ISBN:0-87969-433-5] is_a: WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000027 ! L2 larva Ce [Term] id: WBls:0000033 name: postdauer-L4 lethargus Ce def: "The stage during postdauer-L4 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old." [wb:wjc] is_a: WBls:0000034 ! postdauer-L4 molt Ce [Term] id: WBls:0000034 name: postdauer-L4 molt Ce def: "The stage when an animal shifts from post dauer stage to L4 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000052 ! post dauer stage Ce [Term] id: WBls:0000035 name: L3 larva Ce def: "The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000027 ! L2 larva Ce relationship: preceded_by WBls:0000029 ! L2-L3 molt Ce [Term] id: WBls:0000036 name: L3-L4 lethargus Ce def: "The stage during L3-L4 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000037 ! L3-L4 molt Ce [Term] id: WBls:0000037 name: L3-L4 molt Ce def: "The stage when an animal shifts from L3 larva to L4 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000035 ! L3 larva Ce [Term] id: WBls:0000038 name: L4 larva Ce def: "The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000032 ! dauer larva Ce relationship: preceded_by WBls:0000035 ! L3 larva Ce relationship: preceded_by WBls:0000037 ! L3-L4 molt Ce [Term] id: WBls:0000039 name: L4-adult lethargus Ce def: "The stage during L4-adult molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000040 ! L4-adult molt Ce [Term] id: WBls:0000040 name: L4-adult molt Ce def: "The stage when an animal shifts from L4 larva to adult. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000038 ! L4 larva Ce [Term] id: WBls:0000041 name: adult Ce def: "The stage after an animal is fully-developed and reaches maturity." [wb:wjc] is_a: WBls:0000022 ! postembryonic Ce relationship: preceded_by WBls:0000023 ! larva Ce relationship: preceded_by WBls:0000038 ! L4 larva Ce relationship: preceded_by WBls:0000040 ! L4-adult molt Ce [Term] id: WBls:0000042 name: L1-L2 ecdysis Ce def: "The stage during L1-L2 molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000026 ! L1-L2 molt Ce relationship: preceded_by WBls:0000025 ! L1-L2 lethargus Ce [Term] id: WBls:0000043 name: L1-L2d molt Ce def: "The stage when an animal shifts from L1 larva to L2d larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000023 ! larva Ce [Term] id: WBls:0000044 name: L1-L2d lethargus Ce def: "The stage during L1-L2d molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old." [wb:wjc] is_a: WBls:0000043 ! L1-L2d molt Ce [Term] id: WBls:0000045 name: L1-L2d ecdysis Ce def: "The stage during L1-L2d molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000043 ! L1-L2d molt Ce [Term] id: WBls:0000046 name: L2d larva Ce def: "A special second stage larva with altered physiology and developmental potential that leads to formation of dauer larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch." [ISBN:0-87969-433-5] is_a: WBls:0000023 ! larva Ce [Term] id: WBls:0000047 name: L2-L3 ecdysis Ce def: "The stage during L2-L3 molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000029 ! L2-L3 molt Ce relationship: preceded_by WBls:0000028 ! L2-L3 lethargus Ce [Term] id: WBls:0000048 name: L2d-dauer ecdysis Ce def: "The stage during L2d-dauer molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000031 ! L2d-dauer molt Ce [Term] id: WBls:0000049 name: L3-L4 ecdysis Ce def: "The stage during L3-L4 molt, after the brief lethargus period, when an animal sheds off old cuticle. " [wb:wjc] is_a: WBls:0000037 ! L3-L4 molt Ce relationship: preceded_by WBls:0000036 ! L3-L4 lethargus Ce [Term] id: WBls:0000050 name: L4-adult ecdysis def: "The stage during L4-adult molt, after the brief lethargus period, when an animal shed off old cuticle. " [wb:wjc] is_a: WBls:0000040 ! L4-adult molt Ce relationship: preceded_by WBls:0000039 ! L4-adult lethargus Ce [Term] id: WBls:0000051 name: postdauer-L4 ecdysis Ce def: "The stage during postdauer-L4 molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000034 ! postdauer-L4 molt Ce [Term] id: WBls:0000052 name: post dauer stage Ce def: "The stage right after an animal recovered from dauer but has not started transformation to L4 larva yet." [wb:wjc] is_a: WBls:0000023 ! larva Ce [Term] id: WBls:0000053 name: L2d-L3 molt Ce def: "The stage when an animal shifts from L2d larva to L3 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000046 ! L2d larva Ce [Term] id: WBls:0000054 name: L2d-L3 lethargus Ce def: "The stage during L2d-L3 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000053 ! L2d-L3 molt Ce [Term] id: WBls:0000055 name: L2d-L3 ecdysis Ce def: "The stage during L2d-L3 molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000053 ! L2d-L3 molt Ce [Term] id: WBls:0000056 name: adult male Ce def: "The stage after an male animal is fully-developed and reaches maturity." [wb:wjc] is_a: WBls:0000041 ! adult Ce [Term] id: WBls:0000057 name: adult hermaphrodite Ce def: "The stage after an hermaphrodite animal is fully-developed and reaches maturity." [wb:wjc] is_a: WBls:0000041 ! adult Ce [Term] id: WBls:0000058 name: pre-reproductive stage adult hermaphrodite Ce def: "Very young adult hermaphrodites that do not have eggs in the uterus yet. At 20 Centigrade: 0 - 13 hours after L4-adult molt. 3 days after first cleaveage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce [Term] id: WBls:0000060 name: reproductive stage adult hermaphrodite Ce def: "Adult hermaphrodites continuously laying fertilized eggs. Hermaphrodite in egg laying stages--usually up to 4/5 days after L4-adult molt at Centigrade. From the first fertilized egg is laid, till all sperms are used. At 20 Centigrade: 13 hours after L4-adult molt until about 5.4 days after the L4-adult molt. 3-8.4 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce [Term] id: WBls:0000061 name: oocyte-laying stage adult hermaphrodite Ce def: "When egg-laying is still going on but intermittent and during which a significant number of oocytes are laid. Included in reproductive stage adult hermaphrodite." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce [Term] id: WBls:0000062 name: post-reproductive stage adult hermaphrodite Ce def: "Adult hermaphrodites that contain no more sperm, thus stop egg-laying, but still alive. At 20 Centigrade: 5.4 days after L4-adult molt until the death. 8.4 - 13.2 (average wild type life span) days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce [Term] id: WBls:0000063 name: newly molted young adult hermaphrodite Ce def: "At 20 Centigrade: 0-24 hours after L4-adult molt." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce [Term] id: WBls:0000064 name: 1-day post-L4 adult hermaphrodite Ce def: "At 20 Centigrade: 24-48 hours after L4-adult molt. 4-5 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce [Term] id: WBls:0000065 name: 2-days post-L4 adult hermaphrodite Ce def: "At 20 Centigrade: 48-72 hours after L4-adult molt. 5-6 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce relationship: preceded_by WBls:0000064 ! 1-day post-L4 adult hermaphrodite Ce [Term] id: WBls:0000066 name: 3-days post-L4 adult hermaphrodite Ce def: "At 20 Centigrade: 72-96 hours after L4-adult molt. 6-7 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce relationship: preceded_by WBls:0000065 ! 2-days post-L4 adult hermaphrodite Ce [Term] id: WBls:0000067 name: 4-days post-L4 adult hermaphrodite Ce def: "At 20 Centigrade: 96-120 hours after L4-adult molt. 7-8 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce relationship: preceded_by WBls:0000066 ! 3-days post-L4 adult hermaphrodite Ce [Term] id: WBls:0000068 name: 5-days post-L4 adult hermaphrodite Ce def: "At 20 Centigrade: 5-6 days after L4-adult molt. 8-9 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce relationship: preceded_by WBls:0000067 ! 4-days post-L4 adult hermaphrodite Ce [Term] id: WBls:0000069 name: 4-7 days post-L4 adult hermaphrodite Ce def: "At 20 Centigrade: 4-7 days after L4-adult molt. 7-10 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce relationship: preceded_by WBls:0000068 ! 5-days post-L4 adult hermaphrodite Ce [Term] id: WBls:0000070 name: 7-10 days post-L4 adult hermaphrodite Ce def: "At 20 Centigrade: 7-10 days after L4-adult molt. 10-13 days after first cleavage. Usually this is the end of wild type C. elegans life span." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite Ce relationship: preceded_by WBls:0000069 ! 4-7 days post-L4 adult hermaphrodite Ce [Term] id: WBls:0000071 name: 8-cell embryo Ce def: "~50 min after first cleavage at 20 Centigrade. Contains 8 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo Ce relationship: preceded_by WBls:0000008 ! 4-cell embryo Ce [Term] id: WBls:0000072 name: 12-cell embryo Ce def: "~55 min after first cleavage at 20 Centigrade. Contains 12 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo Ce relationship: preceded_by WBls:0000071 ! 8-cell embryo Ce [Term] id: WBls:0000073 name: L4 larva male Ce def: "The fourth stage larva male. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch." [wb:wjc] is_a: WBls:0000038 ! L4 larva Ce [Term] id: WBls:0000074 Ce name: 11-15 days post-L4 adult hermaphrodite def: "At 20 Centigrade\\: 11-15 days after L4-adult molt. 14-18 days after first cleavage." [wb:dr] is_a: WBls:0000057 ! adult hermaphrodite Ce relationship: preceded_by WBls:0000070 ! 7-10 days post-L4 adult hermaphrodite Ce created_by: danielaraciti creation_date: 2012-05-22T14:35:04Z [Term] id: WBls:0000075 name: Nematoda Life Stage created_by: danielaraciti creation_date: 2012-05-30T09:04:28Z [Term] id: WBls:0000076 name: B. malayi Development def: "All B. malayi development stages, including embryo, larva and adult stage." [wb:dr] is_a: WBls:0000075 ! Nematoda Life Stage created_by: danielaraciti creation_date: 2012-05-30T09:07:05Z [Term] id: WBls:0000077 name: sheathed microfilaria Bma def: "Microfilaria is the stage which develops from the egg and precedes the L1 stage. The larvae are surrounded by a membrane thought to be derived from the vitelline membrane." [wb:dr&mb] synonym: "microfilaria" EXACT [] is_a: WBls:0000097 ! larva Bma created_by: danielaraciti creation_date: 2012-05-30T09:23:44Z [Term] id: WBls:0000079 name: L1 larva Bma alt_id: WBls:0000078 def: "The first stage larva. Also known as vector-derived microfilaria. The microfilaria sheds the sheath and matures to a 'proper L1' in the bloodmeal in the vector gut, and then migrates to the muscles." [WB:dr&mb] synonym: "unsheathed microfilaria Bma" EXACT [] is_a: WBls:0000097 ! larva Bma relationship: preceded_by WBls:0000077 ! sheathed microfilaria Bma created_by: danielaraciti creation_date: 2012-05-30T09:29:36Z [Term] id: WBls:0000080 name: L2 larva Bma def: "The second stage larva. Derived from flight muscles of vector host; some development in vitro, with L1 to L2 moulting, has been demonstrated but rarely; these are often staged by hours or days post blood meal." [wb:dr&mb] is_a: WBls:0000097 ! larva Bma relationship: preceded_by WBls:0000079 ! L1 larva Bma created_by: danielaraciti creation_date: 2012-05-30T09:30:40Z [Term] id: WBls:0000081 name: L3 larva Bma def: "The third stage larva." [wb:dr&mb] is_a: WBls:0000097 ! larva Bma relationship: preceded_by WBls:0000080 ! L2 larva Bma created_by: danielaraciti creation_date: 2012-05-30T09:31:06Z [Term] id: WBls:0000082 name: L4 larva Bma def: "The fourth stage larva. Should be conditioned by days post infection; as moulting is not synchronous, some samples are defined as L3/L4, indicating a mix of individuals as late L3, moulting, and early L4." [wb:dr&mb] is_a: WBls:0000097 ! larva Bma relationship: preceded_by WBls:0000081 ! L3 larva Bma created_by: danielaraciti creation_date: 2012-05-30T09:31:38Z [Term] id: WBls:0000083 name: adult Bma def: "Adults (or at least adult females) can live for 10 years in a human host, and can outlive their rodent laboratory hosts; it is usual to state the chronological age of the nematodes in days or months post-infection, and occasionally post-patency (the production of first microfilariae)." [WB:dr&mb] is_a: WBls:0000093 ! postembryonic Bma relationship: preceded_by WBls:0000100 ! young adult Bma created_by: danielaraciti creation_date: 2012-05-30T09:32:18Z [Term] id: WBls:0000084 name: 14-cell embryo Ce def: "E-cell has divided into Ea and Ep. Contains 14 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000005 ! blastula embryo Ce relationship: preceded_by WBls:0000072 ! 12-cell embryo Ce created_by: danielaraciti creation_date: 2012-10-02T17:15:41Z [Term] id: WBls:0000085 name: 24-cell embryo Ce def: "Fourth cleavage of the AB lineage. Contains 24 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000005 ! blastula embryo Ce relationship: preceded_by WBls:0000084 ! 14-cell embryo Ce created_by: danielaraciti creation_date: 2012-10-02T17:23:32Z [Term] id: WBls:0000086 name: 44-cell embryo Ce def: "Fifth cleavage of the AB lineage. Contains 44 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000010 ! gastrulating embryo Ce relationship: preceded_by WBls:0000009 ! 28-cell embryo Ce created_by: danielaraciti creation_date: 2012-10-02T17:25:18Z [Term] id: WBls:0000087 name: 68-cell embryo Ce def: "Sixth cleavage of the AB lineage. Contains 68 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000010 ! gastrulating embryo Ce relationship: preceded_by WBls:0000011 ! 51-cell embryo Ce created_by: danielaraciti creation_date: 2012-10-02T17:26:52Z [Term] id: WBls:0000088 name: 86-cell embryo Ce def: "Seventh cleavage of the AB lineage. Contains 86 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000010 ! gastrulating embryo Ce relationship: preceded_by WBls:0000087 ! 68-cell embryo Ce created_by: danielaraciti creation_date: 2012-10-02T17:27:50Z [Term] id: WBls:0000089 name: 190-cells embryo Ce def: "P4 and M cells have finished migrating. Contains 190 cells." [wb:dr] is_a: WBls:0000010 ! gastrulating embryo Ce relationship: preceded_by WBls:0000090 ! 96-cell embryo Ce created_by: danielaraciti creation_date: 2012-10-15T13:19:10Z [Term] id: WBls:0000090 name: 96-cell embryo Ce def: "155-165 min after first cleavage at 20 Centigrade. Contains 96 cells." [wb:dr] is_a: WBls:0000010 ! gastrulating embryo Ce relationship: preceded_by WBls:0000012 ! 88-cell embryo Ce created_by: danielaraciti creation_date: 2012-10-16T15:37:30Z [Term] id: WBls:0000091 name: all stages Bma def: "All B. malayi developmental stages, including embryo, larva and adult stage." [wb:dr&mb] is_a: WBls:0000076 ! B. malayi Development created_by: danielaraciti creation_date: 2013-11-12T03:18:57Z [Term] id: WBls:0000092 name: embryo Bma def: "The whole period of embryogenesis, from the formation of an egg till its hatch." [WB:dr] is_a: WBls:0000091 ! all stages Bma created_by: danielaraciti creation_date: 2013-11-12T04:48:28Z [Term] id: WBls:0000093 name: postembryonic Bma def: "The stage after hatch till death." [WB:dr] is_a: WBls:0000091 ! all stages Bma relationship: preceded_by WBls:0000092 ! embryo Bma created_by: danielaraciti creation_date: 2013-11-12T04:50:29Z [Term] id: WBls:0000094 name: early embryo Bma def: "Proliferates from 1 to 100 cells. As the Brugia female reproductive tract is long (>10 cm), it is possible to dissect it and select early embryos just by isolating early parts of the post-spermatheca uterus." [WB:dr&mb] is_a: WBls:0000092 ! embryo Bma created_by: danielaraciti creation_date: 2013-11-12T04:55:53Z [Term] id: WBls:0000095 name: middle embryo Bma def: "Proliferates from 100 cells to Lima bean stage." [WB:dr&mb] is_a: WBls:0000092 ! embryo Bma relationship: preceded_by WBls:0000094 ! early embryo Bma created_by: danielaraciti creation_date: 2013-11-12T04:59:19Z [Term] id: WBls:0000096 name: late embryo Bma def: "From Lima bean to hatching." [WB:dr&mb] is_a: WBls:0000092 ! embryo Bma relationship: preceded_by WBls:0000095 ! middle embryo Bma created_by: danielaraciti creation_date: 2013-11-12T05:00:28Z [Term] id: WBls:0000097 name: larva Bma def: "From the time after hatch till becomes adult." [WB:dr] is_a: WBls:0000093 ! postembryonic Bma relationship: preceded_by WBls:0000092 ! embryo Bma created_by: danielaraciti creation_date: 2013-11-12T05:12:19Z [Term] id: WBls:0000098 name: vector-derived L3 Bma def: "Also known as infective L3, or iL3; i.e. isolated from the vector salivary glands; these samples may-should be conditioned by age, which is usually counted in days from the blood meal." [wb:dr&mb] synonym: "iL3" RELATED [] synonym: "infective L3" RELATED [] is_a: WBls:0000081 ! L3 larva Bma created_by: danielaraciti creation_date: 2013-11-12T05:23:54Z [Term] id: WBls:0000099 name: post-infection L3 Bma def: "Derived from the host after reintroduction by vector feeding or manual inoculation; these piL3 samples are often-should be conditioned by age (hours or days post-infection)." [wb:dr&mb] synonym: "piL3" RELATED [] is_a: WBls:0000081 ! L3 larva Bma created_by: danielaraciti creation_date: 2013-11-12T05:24:59Z [Term] id: WBls:0000100 name: young adult Bma def: "The animals have a significant \"prepatent\" period in the host, where they have moulted to adults but not yet started producing eggs or sperm; this stage is usually-should be conditioned by days post infection, with day 26 to approximately day 60 being the \"young adult\" in most systems - but note that the speed of development is different in different host genotypes." [wb:dr&mb] is_a: WBls:0000093 ! postembryonic Bma relationship: preceded_by WBls:0000082 ! L4 larva Bma created_by: danielaraciti creation_date: 2013-11-12T05:37:52Z [Term] id: WBls:0000101 name: all stages def: "All developmental stages, including embryo, larva and adult stage." [wb:dr] is_a: WBls:0000075 ! Nematoda Life Stage created_by: danielaraciti creation_date: 2013-11-25T06:13:37Z [Term] id: WBls:0000102 name: embryo def: "The whole period of embryogenesis, from the formation of an egg till its hatch." [wb:dr] is_a: WBls:0000101 ! all stages created_by: danielaraciti creation_date: 2013-11-25T06:14:14Z [Term] id: WBls:0000103 name: postembryonic def: "The stage after hatch till death." [wb:dr] is_a: WBls:0000101 ! all stages relationship: preceded_by WBls:0000102 ! embryo created_by: danielaraciti creation_date: 2013-11-25T06:14:39Z [Term] id: WBls:0000104 name: adult def: "The stage after an animal is fully-developed and reaches maturity." [wb:dr] is_a: WBls:0000103 ! postembryonic relationship: preceded_by WBls:0000105 ! larva created_by: danielaraciti creation_date: 2013-11-25T06:18:53Z [Term] id: WBls:0000105 name: larva def: "From the time after hatch till becomes adult." [wb:dr] is_a: WBls:0000103 ! postembryonic created_by: danielaraciti creation_date: 2013-11-25T06:19:27Z [Term] id: WBls:0000106 name: L1 larva def: "The first stage larva." [wb:dr] is_a: WBls:0000105 ! larva relationship: preceded_by WBls:0000110 ! sheathed microfilaria created_by: danielaraciti creation_date: 2013-11-25T06:20:28Z [Term] id: WBls:0000107 name: L2 larva def: "The second stage larva." [wb:dr] is_a: WBls:0000105 ! larva relationship: preceded_by WBls:0000106 ! L1 larva created_by: danielaraciti creation_date: 2013-11-25T06:20:54Z [Term] id: WBls:0000108 name: L3 larva def: "The third stage larva." [wb:dr] is_a: WBls:0000105 ! larva relationship: preceded_by WBls:0000107 ! L2 larva created_by: danielaraciti creation_date: 2013-11-25T06:21:33Z [Term] id: WBls:0000109 name: L4 larva def: "The fourth stage larva." [wb:dr] is_a: WBls:0000105 ! larva relationship: preceded_by WBls:0000108 ! L3 larva created_by: danielaraciti creation_date: 2013-11-25T06:22:48Z [Term] id: WBls:0000110 name: sheathed microfilaria def: "Microfilaria is the stage which develops from the egg and precedes the L1 stage. The larvae are surrounded by a membrane thought to be derived from the vitelline membrane." [wb:dr] is_a: WBls:0000105 ! larva created_by: danielaraciti creation_date: 2013-11-25T06:23:23Z [Typedef] id: is_a name: is a [Typedef] id: preceded_by name: preceded by created_by: danielaraciti creation_date: 2013-02-11T12:05:25Z