format-version: 1.2 date: 15:11:2013 02:42 saved-by: danielaraciti auto-generated-by: OBO-Edit 2.2-rc1 default-namespace: worm_development remark: Version: 1.04 remark: Editors: Wen J. Chen & Daniela Raciti, WormBase, Caltech [Term] id: WBls:0000001 name: C. elegans Development is_a: WBls:0000075 ! Nematoda Life Stage [Term] id: WBls:0000002 name: all stages def: "All C. elegans development stages, including embryo, larva and adult stage." [wb:wjc] is_a: WBls:0000001 ! C. elegans Development [Term] id: WBls:0000003 name: embryo def: "The whole period of embryogenesis, from the formation of an egg till its hatch. " [wb:wjc] is_a: WBls:0000002 ! all stages [Term] id: WBls:0000004 name: proliferating embryo def: "0-350min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 560 cells. From start of first cleavage till cleavage is over." [wb:wjc] is_a: WBls:0000003 ! embryo [Term] id: WBls:0000005 name: blastula embryo def: "0-100min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 28 cells. From first cleavage till the start of gastrulation." [wb:wjc] is_a: WBls:0000004 ! proliferating embryo [Term] id: WBls:0000006 name: 1-cell embryo def: "Also called zygote. -50min till 0min of first cleavage at 20 Centigrade. Contains 1 cell." [wb:wjc] is_a: WBls:0000005 ! blastula embryo [Term] id: WBls:0000007 name: 2-cell embryo def: "0-20min after first cleavage at 20 Centigrade. Contains 2 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo relationship: preceded_by WBls:0000006 ! 1-cell embryo [Term] id: WBls:0000008 name: 4-cell embryo def: "20-40min after first cleavage at 20 Centigrade. Contains 4 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo relationship: preceded_by WBls:0000007 ! 2-cell embryo [Term] id: WBls:0000009 name: 28-cell embryo def: "100-105 min after first cleaveage at 20 Centigrade. Contains 28 cells." [wb:wjc] is_a: WBls:0000010 ! gastrulating embryo [Term] id: WBls:0000010 name: gastrulating embryo def: "100-290min after first cleavage at 20 Centigrade. Proliferate from 28 cells to 421 cells. Referring to the whole period of gastrulation." [wb:wjc] is_a: WBls:0000004 ! proliferating embryo relationship: preceded_by WBls:0000005 ! blastula embryo [Term] id: WBls:0000011 name: 51-cell embryo def: "120-135 min after first cleavage at 20 Centigrade. Contains 51 cells." [wb:wjc] is_a: WBls:0000010 ! gastrulating embryo relationship: preceded_by WBls:0000086 ! 44-cell embryo [Term] id: WBls:0000012 name: 88-cell embryo def: "145-150 min after first cleavage at 20 Centigrade. Contains 88 cells." [wb:wjc] is_a: WBls:0000010 ! gastrulating embryo relationship: preceded_by WBls:0000088 ! 86-cell embryo [Term] id: WBls:0000013 name: enclosing embryo def: "290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastulation and is enclosing." [wb:wjc] is_a: WBls:0000014 ! late cleavage stage embryo relationship: preceded_by WBls:0000010 ! gastrulating embryo relationship: preceded_by WBls:0000014 ! late cleavage stage embryo [Term] id: WBls:0000014 name: late cleavage stage embryo def: "210-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage before the fast cleavage of cells finishes. " [wb:wjc] is_a: WBls:0000004 ! proliferating embryo relationship: preceded_by WBls:0000010 ! gastrulating embryo [Term] id: WBls:0000015 name: elongating embryo def: "350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation till elongation is over." [wb:wjc] is_a: WBls:0000003 ! embryo relationship: preceded_by WBls:0000004 ! proliferating embryo relationship: preceded_by WBls:0000010 ! gastrulating embryo [Term] id: WBls:0000016 name: bean embryo def: "350-390min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. Emrbyo elongation started but have not formed comma shape yet. The shape of embryo looks like a lima bean. A stage right before comma embryo. Also called lima embryo or lima bean stage." [wb:wjc] is_a: WBls:0000015 ! elongating embryo relationship: preceded_by WBls:0000013 ! enclosing embryo relationship: preceded_by WBls:0000014 ! late cleavage stage embryo [Term] id: WBls:0000017 name: comma embryo def: "390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo. " [wb:wjc] is_a: WBls:0000015 ! elongating embryo relationship: preceded_by WBls:0000016 ! bean embryo [Term] id: WBls:0000018 name: 1.5-fold embryo def: "420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo." [wb:wjc] is_a: WBls:0000015 ! elongating embryo relationship: preceded_by WBls:0000017 ! comma embryo [Term] id: WBls:0000019 name: 2-fold embryo def: "460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo." [wb:wjc] is_a: WBls:0000015 ! elongating embryo relationship: preceded_by WBls:0000018 ! 1.5-fold embryo [Term] id: WBls:0000020 name: 3-fold embryo def: "520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage." [wb:wjc] is_a: WBls:0000015 ! elongating embryo relationship: preceded_by WBls:0000019 ! 2-fold embryo [Term] id: WBls:0000021 name: fully-elongated embryo def: "620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo." [wb:wjc] is_a: WBls:0000003 ! embryo relationship: preceded_by WBls:0000015 ! elongating embryo relationship: preceded_by WBls:0000020 ! 3-fold embryo [Term] id: WBls:0000022 name: postembryonic def: "The stage after hatch till death." [wb:wjc] is_a: WBls:0000002 ! all stages relationship: preceded_by WBls:0000003 ! embryo [Term] id: WBls:0000023 name: larva def: "From the time after hatch till becomes adult." [wb:wjc] is_a: WBls:0000022 ! postembryonic relationship: preceded_by WBls:0000003 ! embryo [Term] id: WBls:0000024 name: L1 larva def: "The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva relationship: preceded_by WBls:0000003 ! embryo [Term] id: WBls:0000025 name: L1-L2 lethargus def: "The stage during L1-L2 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000026 ! L1-L2 molt [Term] id: WBls:0000026 name: L1-L2 molt def: "The stage when an animal shifts from L1 larva to L2 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000024 ! L1 larva relationship: preceded_by WBls:0000024 ! L1 larva [Term] id: WBls:0000027 name: L2 larva def: "The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva relationship: preceded_by WBls:0000024 ! L1 larva relationship: preceded_by WBls:0000026 ! L1-L2 molt [Term] id: WBls:0000028 name: L2-L3 lethargus def: "The stage during L2-L3 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000029 ! L2-L3 molt [Term] id: WBls:0000029 name: L2-L3 molt def: "The stage when an animal shifts from L2 larva to L3 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000027 ! L2 larva relationship: preceded_by WBls:0000027 ! L2 larva [Term] id: WBls:0000030 name: L2d-dauer lethargus def: "The stage during L2d-dauer molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000031 ! L2d-dauer molt [Term] id: WBls:0000031 name: L2d-dauer molt def: "The stage when an animal shifts from L2d larva to dauer larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle. " [wb:wjc] is_a: WBls:0000046 ! L2d larva [Term] id: WBls:0000032 name: dauer larva def: "A third stage larva specialized for dispersal and long term survival. " [ISBN:0-87969-433-5] is_a: WBls:0000023 ! larva relationship: preceded_by WBls:0000027 ! L2 larva [Term] id: WBls:0000033 name: postdauer-L4 lethargus def: "The stage during postdauer-L4 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old." [wb:wjc] is_a: WBls:0000034 ! postdauer-L4 molt [Term] id: WBls:0000034 name: postdauer-L4 molt def: "The stage when an animal shifts from post dauer stage to L4 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000052 ! post dauer stage [Term] id: WBls:0000035 name: L3 larva def: "The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva relationship: preceded_by WBls:0000027 ! L2 larva relationship: preceded_by WBls:0000029 ! L2-L3 molt [Term] id: WBls:0000036 name: L3-L4 lethargus def: "The stage during L3-L4 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000037 ! L3-L4 molt [Term] id: WBls:0000037 name: L3-L4 molt def: "The stage when an animal shifts from L3 larva to L4 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000035 ! L3 larva relationship: preceded_by WBls:0000035 ! L3 larva [Term] id: WBls:0000038 name: L4 larva def: "The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch." [wb:wjc] is_a: WBls:0000023 ! larva relationship: preceded_by WBls:0000035 ! L3 larva relationship: preceded_by WBls:0000037 ! L3-L4 molt [Term] id: WBls:0000039 name: L4-adult lethargus def: "The stage during L4-adult molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000040 ! L4-adult molt [Term] id: WBls:0000040 name: L4-adult molt def: "The stage when an animal shifts from L4 larva to adult. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000038 ! L4 larva [Term] id: WBls:0000041 name: adult is_a: WBls:0000022 ! postembryonic relationship: preceded_by WBls:0000023 ! larva relationship: preceded_by WBls:0000038 ! L4 larva relationship: preceded_by WBls:0000040 ! L4-adult molt [Term] id: WBls:0000042 name: L1-L2 ecdysis def: "The stage during L1-L2 molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000026 ! L1-L2 molt relationship: preceded_by WBls:0000025 ! L1-L2 lethargus [Term] id: WBls:0000043 name: L1-L2d molt def: "The stage when an animal shifts from L1 larva to L2d larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000024 ! L1 larva [Term] id: WBls:0000044 name: L1-L2d lethargus def: "The stage during L1-L2d molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000043 ! L1-L2d molt [Term] id: WBls:0000045 name: L1-L2d ecdysis def: "The stage during L1-L2d molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000043 ! L1-L2d molt [Term] id: WBls:0000046 name: L2d larva def: "A special second stage larva with altered physiology and developmental potential that leads to formation of dauer larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch." [ISBN:0-87969-433-5] is_a: WBls:0000023 ! larva [Term] id: WBls:0000047 name: L2-L3 ecdysis def: "The stage during L2-L3 molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000029 ! L2-L3 molt relationship: preceded_by WBls:0000028 ! L2-L3 lethargus [Term] id: WBls:0000048 name: L2d-dauer ecdysis def: "The stage during L2d-dauer molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000031 ! L2d-dauer molt [Term] id: WBls:0000049 name: L3-L4 ecdysis def: "The stage during L3-L4 molt, after the brief lethargus period, when an animal sheds off old cuticle. " [wb:wjc] is_a: WBls:0000037 ! L3-L4 molt relationship: preceded_by WBls:0000036 ! L3-L4 lethargus [Term] id: WBls:0000050 name: L4-adult ecdysis def: "The stage during L4-adult molt, after the brief lethargus period, when an animal shed off old cuticle. " [wb:wjc] is_a: WBls:0000040 ! L4-adult molt relationship: preceded_by WBls:0000039 ! L4-adult lethargus [Term] id: WBls:0000051 name: postdauer-L4 ecdysis def: "The stage during postdauer-L4 molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000034 ! postdauer-L4 molt [Term] id: WBls:0000052 name: post dauer stage def: "The stage right after an animal recovered from dauer but has not started transformation to L4 larva yet." [wb:wjc] is_a: WBls:0000023 ! larva [Term] id: WBls:0000053 name: L2d-L3 molt def: "The stage when an animal shifts from L2d larva to L3 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle." [wb:wjc] is_a: WBls:0000046 ! L2d larva [Term] id: WBls:0000054 name: L2d-L3 lethargus def: "The stage during L2d-L3 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. " [wb:wjc] is_a: WBls:0000053 ! L2d-L3 molt [Term] id: WBls:0000055 name: L2d-L3 ecdysis def: "The stage during L2d-L3 molt, after the brief lethargus period, when an animal sheds off old cuticle." [wb:wjc] is_a: WBls:0000053 ! L2d-L3 molt [Term] id: WBls:0000056 name: adult male def: "The stage after an male animal is fully-developed and reaches maturity." [wb:wjc] is_a: WBls:0000041 ! adult [Term] id: WBls:0000057 name: adult hermaphrodite def: "The stage after an hermaphrodite animal is fully-developed and reaches maturity." [wb:wjc] is_a: WBls:0000041 ! adult [Term] id: WBls:0000058 name: pre-reproductive stage adult hermaphrodite def: "Very young adult hermaphrodites that do not have eggs in the uterus yet. At 20 Centigrade: 0 - 13 hours after L4-adult molt. 3 days after first cleaveage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000060 name: reproductive stage adult hermaphrodite def: "Adult hermaphrodites continuously laying fertilized eggs. Hermaphrodite in egg laying stages--usually up to 4/5 days after L4-adult molt at Centigrade. From the first fertilized egg is laid, till all sperms are used. At 20 Centigrade: 13 hours after L4-adult molt until about 5.4 days after the L4-adult molt. 3-8.4 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000061 name: oocyte-laying stage adult hermaphrodite def: "When egg-laying is still going on but intermittent and during which a significant number of oocytes are laid. Included in reproductive stage adult hermaphrodite." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000062 name: post-reproductive stage adult hermaphrodite def: "Adult hermaphrodites that contain no more sperm, thus stop egg-laying, but still alive. At 20 Centigrade: 5.4 days after L4-adult molt until the death. 8.4 - 13.2 (average wild type life span) days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000063 name: newly molted young adult hermaphrodite def: "At 20 Centigrade: 0-24 hours after L4-adult molt." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000064 name: 1-day post-L4 adult hermaphrodite def: "At 20 Centigrade: 24-48 hours after L4-adult molt. 4-5 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite [Term] id: WBls:0000065 name: 2-days post-L4 adult hermaphrodite def: "At 20 Centigrade: 48-72 hours after L4-adult molt. 5-6 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite relationship: preceded_by WBls:0000064 ! 1-day post-L4 adult hermaphrodite [Term] id: WBls:0000066 name: 3-days post-L4 adult hermaphrodite def: "At 20 Centigrade: 72-96 hours after L4-adult molt. 6-7 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite relationship: preceded_by WBls:0000065 ! 2-days post-L4 adult hermaphrodite [Term] id: WBls:0000067 name: 4-days post-L4 adult hermaphrodite def: "At 20 Centigrade: 96-120 hours after L4-adult molt. 7-8 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite relationship: preceded_by WBls:0000066 ! 3-days post-L4 adult hermaphrodite [Term] id: WBls:0000068 name: 5-days post-L4 adult hermaphrodite def: "At 20 Centigrade: 5-6 days after L4-adult molt. 8-9 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite relationship: preceded_by WBls:0000067 ! 4-days post-L4 adult hermaphrodite [Term] id: WBls:0000069 name: 4-7 days post-L4 adult hermaphrodite def: "At 20 Centigrade: 4-7 days after L4-adult molt. 7-10 days after first cleavage." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite relationship: preceded_by WBls:0000068 ! 5-days post-L4 adult hermaphrodite [Term] id: WBls:0000070 name: 7-10 days post-L4 adult hermaphrodite def: "At 20 Centigrade: 7-10 days after L4-adult molt. 10-13 days after first cleavage. Usually this is the end of wild type C. elegans life span." [wb:wjc] is_a: WBls:0000057 ! adult hermaphrodite relationship: preceded_by WBls:0000069 ! 4-7 days post-L4 adult hermaphrodite [Term] id: WBls:0000071 name: 8-cell embryo def: "~50 min after first cleavage at 20 Centigrade. Contains 8 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo relationship: preceded_by WBls:0000008 ! 4-cell embryo [Term] id: WBls:0000072 name: 12-cell embryo def: "~55 min after first cleavage at 20 Centigrade. Contains 12 cells." [wb:wjc] is_a: WBls:0000005 ! blastula embryo relationship: preceded_by WBls:0000071 ! 8-cell embryo [Term] id: WBls:0000073 name: L4 larva male def: "The fourth stage larva male. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch." [wb:wjc] is_a: WBls:0000038 ! L4 larva [Term] id: WBls:0000074 name: 11-15 days post-L4 adult hermaphrodite def: "At 20 Centigrade\\: 11-15 days after L4-adult molt. 14-18 days after first cleavage." [wb:dr] is_a: WBls:0000057 ! adult hermaphrodite relationship: preceded_by WBls:0000070 ! 7-10 days post-L4 adult hermaphrodite created_by: danielaraciti creation_date: 2012-05-22T14:35:04Z [Term] id: WBls:0000075 name: Nematoda Life Stage created_by: danielaraciti creation_date: 2012-05-30T09:04:28Z [Term] id: WBls:0000076 name: B. malayi Life Stage def: "All B. malayi development stages, including embryo, larva and adult stage." [wb:dr] is_a: WBls:0000075 ! Nematoda Life Stage created_by: danielaraciti creation_date: 2012-05-30T09:07:05Z [Term] id: WBls:0000077 name: sheathed microfilaria Bma def: "Microfilaria is the stage which develops from the egg and precedes the L1 stage. The larvae are surrounded by a membrane thought to be derived from the vitelline membrane." [wb:dr&mb] synonym: "" RELATED [] synonym: "microfilaria" EXACT [] is_a: WBls:0000097 ! larva Bma created_by: danielaraciti creation_date: 2012-05-30T09:23:44Z [Term] id: WBls:0000079 name: L1 larva Bma alt_id: WBls:0000078 def: "The first stage larva. Also known as vector-derived microfilaria. The microfilaria sheds the sheath and matures to a 'proper L1' in the bloodmeal in the vector gut, and then migrates to the muscles." [WB:dr&mb] synonym: "unsheathed microfilaria Bma" EXACT [] is_a: WBls:0000097 ! larva Bma relationship: preceded_by WBls:0000077 ! sheathed microfilaria Bma created_by: danielaraciti creation_date: 2012-05-30T09:29:36Z [Term] id: WBls:0000080 name: L2 larva Bma def: "The second stage larva. Derived from flight muscles of vector host; some development in vitro, with L1 to L2 moulting, has been demonstrated but rarely; these are often staged by hours or days post blood meal." [wb:dr&mb] is_a: WBls:0000097 ! larva Bma relationship: preceded_by WBls:0000079 ! L1 larva Bma created_by: danielaraciti creation_date: 2012-05-30T09:30:40Z [Term] id: WBls:0000081 name: L3 larva Bma def: "The third stage larva." [wb:dr&mb] is_a: WBls:0000097 ! larva Bma relationship: preceded_by WBls:0000080 ! L2 larva Bma created_by: danielaraciti creation_date: 2012-05-30T09:31:06Z [Term] id: WBls:0000082 name: L4 larva Bma def: "The fourth stage larva. Should be conditioned by days post infection; as moulting is not synchronous, some samples are defined as L3/L4, indicating a mix of individuals as late L3, moulting, and early L4." [wb:dr&mb] is_a: WBls:0000097 ! larva Bma relationship: preceded_by WBls:0000081 ! L3 larva Bma created_by: danielaraciti creation_date: 2012-05-30T09:31:38Z [Term] id: WBls:0000083 name: adult Bma def: "Adults (or at least adult females) can live for 10 years in a human host, and can outlive their rodent laboratory hosts; it is usual to state the chronological age of the nematodes in days or months post-infection, and occasionally post-patency (the production of first microfilariae." [WB:dr&mb] is_a: WBls:0000093 ! postembryonic Bma relationship: preceded_by WBls:0000100 ! young adult created_by: danielaraciti creation_date: 2012-05-30T09:32:18Z [Term] id: WBls:0000084 name: 14-cell embryo def: "E-cell has divided into Ea and Ep. Contains 14 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000005 ! blastula embryo relationship: preceded_by WBls:0000072 ! 12-cell embryo created_by: danielaraciti creation_date: 2012-10-02T17:15:41Z [Term] id: WBls:0000085 name: 24-cell embryo def: "Fourth cleavage of the AB lineage. Contains 24 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000005 ! blastula embryo relationship: preceded_by WBls:0000084 ! 14-cell embryo created_by: danielaraciti creation_date: 2012-10-02T17:23:32Z [Term] id: WBls:0000086 name: 44-cell embryo def: "Fifth cleavage of the AB lineage. Contains 44 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000010 ! gastrulating embryo relationship: preceded_by WBls:0000009 ! 28-cell embryo created_by: danielaraciti creation_date: 2012-10-02T17:25:18Z [Term] id: WBls:0000087 name: 68-cell embryo def: "Sixth cleavage of the AB lineage. Contains 68 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000010 ! gastrulating embryo relationship: preceded_by WBls:0000011 ! 51-cell embryo created_by: danielaraciti creation_date: 2012-10-02T17:26:52Z [Term] id: WBls:0000088 name: 86-cell embryo def: "Seventh cleavage of the AB lineage. Contains 86 cells." [wb:dr] comment: Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1. is_a: WBls:0000010 ! gastrulating embryo relationship: preceded_by WBls:0000087 ! 68-cell embryo created_by: danielaraciti creation_date: 2012-10-02T17:27:50Z [Term] id: WBls:0000089 name: 190-cells embryo def: "P4 and M cells have finished migrating. Contains 190 cells." [wb:dr] is_a: WBls:0000010 ! gastrulating embryo relationship: preceded_by WBls:0000090 ! 96-cell embryo created_by: danielaraciti creation_date: 2012-10-15T13:19:10Z [Term] id: WBls:0000090 name: 96-cell embryo def: "155-165 min after first cleavage at 20 Centigrade. Contains 96 cells." [wb:dr] is_a: WBls:0000010 ! gastrulating embryo relationship: preceded_by WBls:0000012 ! 88-cell embryo created_by: danielaraciti creation_date: 2012-10-16T15:37:30Z [Term] id: WBls:0000091 name: all stages Bma def: "All B. malayi developmental stages, including embryo, larva and adult stage." [wb:dr&mb] is_a: WBls:0000076 ! B. malayi Life Stage created_by: danielaraciti creation_date: 2013-11-12T03:18:57Z [Term] id: WBls:0000092 name: embryo Bma def: "The whole period of embryogenesis, from the formation of an egg till its hatch." [WB:dr] is_a: WBls:0000091 ! all stages Bma created_by: danielaraciti creation_date: 2013-11-12T04:48:28Z [Term] id: WBls:0000093 name: postembryonic Bma def: "The stage after hatch till death." [WB:dr] is_a: WBls:0000091 ! all stages Bma relationship: preceded_by WBls:0000092 ! embryo Bma created_by: danielaraciti creation_date: 2013-11-12T04:50:29Z [Term] id: WBls:0000094 name: early embryo Bma def: "Proliferates from 1 to 100 cells. As the Brugia female reproductive tract is long (>10 cm), it is possible to dissect it and select early embryos just by isolating early parts of the post-spermatheca uterus." [WB:dr&mb] is_a: WBls:0000092 ! embryo Bma created_by: danielaraciti creation_date: 2013-11-12T04:55:53Z [Term] id: WBls:0000095 name: middle embryo Bma def: "Proliferates from 100 cells to Lima bean stage." [WB:dr&mb] is_a: WBls:0000092 ! embryo Bma relationship: preceded_by WBls:0000094 ! early embryo Bma created_by: danielaraciti creation_date: 2013-11-12T04:59:19Z [Term] id: WBls:0000096 name: late embryo Bma def: "From Lima bean to hatching." [WB:dr&mb] is_a: WBls:0000092 ! embryo Bma relationship: preceded_by WBls:0000095 ! middle embryo Bma created_by: danielaraciti creation_date: 2013-11-12T05:00:28Z [Term] id: WBls:0000097 name: larva Bma def: "The stage after hatch till death." [WB:dr] is_a: WBls:0000093 ! postembryonic Bma relationship: preceded_by WBls:0000092 ! embryo Bma created_by: danielaraciti creation_date: 2013-11-12T05:12:19Z [Term] id: WBls:0000098 name: vector-derived L3 Bma def: "Also known as infective L3, or iL3; i.e. isolated from the vector salivary glands; these samples may / should be conditioned by age, which is usually counted in days from the blood meal." [wb:dr&mb] synonym: "iL3" RELATED [] synonym: "infective L3" RELATED [] is_a: WBls:0000081 ! L3 larva Bma created_by: danielaraciti creation_date: 2013-11-12T05:23:54Z [Term] id: WBls:0000099 name: post-infection L3 Bma def: "Derived from the host after reintroduction by vector feeding or manual inoculation; these piL3 samples are often / should be conditioned by age (hours or days post-infection)." [wb:dr&mb] synonym: "piL3" RELATED [] is_a: WBls:0000081 ! L3 larva Bma created_by: danielaraciti creation_date: 2013-11-12T05:24:59Z [Term] id: WBls:0000100 name: young adult Bma def: "The animals have a significant \"prepatent\" period in the host, where they have moulted to adults but not yet started producing eggs or sperm; this stage is usually / should be conditioned by days post infection, with day 26 to approximately day 60 being the \"young adult\" in most systems - but note that the speed of development is different in different host genotypes." [wb:dr&mb] is_a: WBls:0000093 ! postembryonic Bma relationship: preceded_by WBls:0000082 ! L4 larva Bma created_by: danielaraciti creation_date: 2013-11-12T05:37:52Z [Typedef] id: is_a name: is a [Typedef] id: preceded_by name: preceded by created_by: danielaraciti creation_date: 2013-02-11T12:05:25Z