format-version: 1.2 date: 17:04:2014 12:49 saved-by: garys auto-generated-by: OBO-Edit 1.002 subsetdef: phenotype_slim_wb "WB phenotype slim" default-namespace: C_elegans_phenotype_ontology [Term] id: WBPhenotype:0000000 name: chromosome instability def: "Variations in the frequencies of translocations, inversions, deletions, or gene amplifications and variations in chromosome fusion events and or chromosomal loss compared to control." [WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0000001 name: body posture variant def: "Animals exhibit variations in body posture compared to control animals. For example, in C. elegans characteristic sinusoidal body posture is altered." [WB:cab, WB:WBPerson557] subset: phenotype_slim_wb synonym: "body posture abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000002 name: kinker def: "The animal moves or rests with uncharacteristic muscle spasms causing loss of smooth sinusoidal motion or body posture. Movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control animals." [WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0004017 ! locomotor coordination variant [Term] id: WBPhenotype:0000004 name: constitutive egg laying def: "Eggs are laid under conditions where egg laying is normally inhibited." [WB:cab] comment: Liquid M9. synonym: "Egl c" BROAD [] is_a: WBPhenotype:0000005 ! hyperactive egg laying [Term] id: WBPhenotype:0000005 name: hyperactive egg laying def: "Eggs are laid at an earlier stage of development, eggs are laid in the presence of inhibitors of egg laying, or the inactive phase of the egg-laying cycle is significantly shorter when compared to control." [WB:cab] is_a: WBPhenotype:0000640 ! egg laying variant [Term] id: WBPhenotype:0000006 name: egg laying defective def: "Eggs are not laid, laid at a slower rate or eggs are laid at a later stage of development compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPaper00025054] synonym: "Egl d" BROAD [] is_a: WBPhenotype:0000640 ! egg laying variant [Term] id: WBPhenotype:0000007 name: bag of worms def: "A worm carcass is formed with retained eggs that hatch inside." [WB:cab] synonym: "Bag" BROAD [] is_a: WBPhenotype:0000862 ! bloated [Term] id: WBPhenotype:0000008 name: anesthetic hypersensitive def: "Animals respond to anesthetic at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] synonym: "anaesthetic hypersensitive" EXACT [] is_a: WBPhenotype:0000010 ! drug hypersensitive is_a: WBPhenotype:0000627 ! anesthetic response variant [Term] id: WBPhenotype:0000009 name: anesthetic resistant def: "Animals fail to respond to the concentration of anesthetic that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] synonym: "anaesthetic resistant" EXACT [] is_a: WBPhenotype:0000011 ! drug resistant is_a: WBPhenotype:0000627 ! anesthetic response variant [Term] id: WBPhenotype:0000010 name: drug hypersensitive def: "Animals respond to a specific drug at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0000011 name: drug resistant def: "Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Animals are not affected by exposure to the drug." [WB:WBPerson557] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0000012 name: dauer constitutive def: "Formation of dauer larvae under conditions that do not favor dauer formation." [WB:kmva] synonym: "Daf c" BROAD [] is_a: WBPhenotype:0000637 ! dauer formation variant [Term] id: WBPhenotype:0000013 name: dauer defective def: "Failure to form dauer larvae under dauer-inducing conditions." [WB:kmva] synonym: "Daf d" BROAD [] is_a: WBPhenotype:0000637 ! dauer formation variant [Term] id: WBPhenotype:0000014 name: cord commissures variant def: "Variations in the structure, organization or path of axon tracts that grow circumferentially around the animal in a single, directed trajectory to bridge the ventral and dorsal cords, compared to control animals." [WB:WBPaper00001499, WB:WBPaper00029065, WB:WBPerson712] synonym: "cord commissures abnormal" NARROW [] is_a: WBPhenotype:0001226 ! commissure variant [Term] id: WBPhenotype:0000015 name: positive chemotaxis defective def: "Variations in the movement towards typically attractive chemicals." [WB:cab] is_a: WBPhenotype:0000635 ! positive chemotaxis variant [Term] id: WBPhenotype:0000016 name: aldicarb hypersensitive def: "Animals respond to aldicarb at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] synonym: "Hic" BROAD [] is_a: WBPhenotype:0000500 ! acetylcholinesterase inhibitor hypersensitive is_a: WBPhenotype:0000680 ! aldicarb response variant [Term] id: WBPhenotype:0000017 name: aldicarb resistant def: "Animals fail to respond to the concentration of aldicarb that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] synonym: "Ald R" BROAD [] synonym: "Ric" BROAD [] is_a: WBPhenotype:0000680 ! aldicarb response variant is_a: WBPhenotype:0001289 ! acetylcholinesterase inhibitor resistant [Term] id: WBPhenotype:0000018 name: pharyngeal pumping increased def: "The contraction and relaxation movements of the pharynx occur at a greater frequency compared to that observed for control animals." [WB:WBPerson712] is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant [Term] id: WBPhenotype:0000019 name: pharyngeal pumping reduced def: "Pharyngeal pumping motion occurs at a slower rate than control animals." [WB:WBPaper00001709] is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant [Term] id: WBPhenotype:0000020 name: pharyngeal pumping irregular def: "Pharyngeal pumping motion occurs at intervals that vary from control animals." [WB:WBPaper00001709] is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant [Term] id: WBPhenotype:0000021 name: squat def: "Squat animals are dumpy as homozygotes, but roll as heterozygotes." [WB:WBPaper00000906] synonym: "Sqt" BROAD [] is_a: WBPhenotype:0000231 ! body size variant [Term] id: WBPhenotype:0000022 name: long def: "Animals are longer and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31] synonym: "Lon" BROAD [] is_a: WBPhenotype:0001726 ! body length variant [Term] id: WBPhenotype:0000023 name: serotonin hypersensitive def: "Animals respond to serotonin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0000024 name: serotonin resistant def: "Animals fail to respond to the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0000025 name: blistered def: "Fluid-filled blisters appear on the cuticle." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497] synonym: "Bli" BROAD [] is_a: WBPhenotype:0000948 ! cuticle morphology variant [Term] id: WBPhenotype:0000026 name: lipid depleted def: "Animals are unable to take up or store lipids. In C. elegans, this defect results in pale, skinny and arrested larva." [GO:0006629, WB:WBPaper00005707, WB:WBPerson712] synonym: "fat depleted" RELATED [] synonym: "Lpd" BROAD [] is_a: WBPhenotype:0001183 ! fat content reduced [Term] id: WBPhenotype:0000027 name: organism metabolism processing variant def: "Variations in the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances compared to control." [GO:0008152, WB:WBPerson2021, WB:WBPerson557] synonym: "organism metabolism processing abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0000028 name: RNA processing variant def: "Variations in the processes involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules compared to control." [GO:0006396, WB:WBPerson2021] synonym: "RNA processing abnormal" NARROW [] is_a: WBPhenotype:0000113 ! RNA expression variant [Term] id: WBPhenotype:0000029 name: systemic RNAi variant def: "Animals are defective for RNAi introduced by environmental means such as in the cases of RNAi triggered by soaking or feeding." [WB:WBPaper00029209, WB:WBPaper00030758, WB:WBPerson712] synonym: "Environmental RNAi defective" RELATED [] synonym: "systemic RNAi abnormal" NARROW [] is_a: WBPhenotype:0000743 ! RNAi response variant [Term] id: WBPhenotype:0000030 name: growth variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) compared to control animals." [GO:0040007, WB:WBPerson2021] synonym: "growth abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0000031 name: slow growth def: "Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557] synonym: "Gro" BROAD [] is_a: WBPhenotype:0000030 ! growth variant is_a: WBPhenotype:0000043 ! general pace of development variant is_a: WBPhenotype:0000438 ! retarded heterochronic variations [Term] id: WBPhenotype:0000032 name: sick def: "Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712] synonym: "Sck" BROAD [] is_a: WBPhenotype:0000030 ! growth variant [Term] id: WBPhenotype:0000033 name: developmental timing variant def: "The timing of specific developmental events in some tissues is altered relative to the timing of events in other tissues." [pmid:6494891, WB:cab] comment: Possible XP GO:0040034. subset: phenotype_slim_wb synonym: "developmental timing abnormal" NARROW [] synonym: "heterochronic defect" EXACT [] is_a: WBPhenotype:0000531 ! organism development variant [Term] id: WBPhenotype:0000034 name: embryonic polarity variant def: "Contents or structures of an embryonic cell are not restricted/localized to the same positions (or poles) compared with control animals." [WB:WBPaper00005079, WB:WBPerson2021, WB:WBPerson712] synonym: "embryonic polarity abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000035 name: larval body morphology variant def: "Any variation in the overall structure or appearance of the animal as it progresses from hatching to adult compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "larval body morphology abnormal" NARROW [] synonym: "larval morphology abnormal" RELATED [] is_a: WBPhenotype:0000072 ! body morphology variant is_a: WBPhenotype:0000934 ! developmental morphology variant [Term] id: WBPhenotype:0000036 name: adult body morphology variant def: "Any variation in the overall structure or appearance of the animal after it has completed progression through the larval stages compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "adult body morphology abnormal" NARROW [] is_a: WBPhenotype:0000072 ! body morphology variant is_a: WBPhenotype:0000934 ! developmental morphology variant [Term] id: WBPhenotype:0000037 name: egg morphology variant def: "Any variation in the overall structure or appearance of fertilized oocytes that are laid compared to those laid by control animals." [WB:WBPaper00001075, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "egg morphology abnormal" NARROW [] is_a: WBPhenotype:0000934 ! developmental morphology variant [Term] id: WBPhenotype:0000038 name: exploded through vulva def: "The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture." [WB:WBPaper00027633, WB:WBPaper00031094, WB:WBPerson712] synonym: "burst vulva" RELATED [] synonym: "gonad eversion" RELATED [] synonym: "gonad exploded through vulva" RELATED [] synonym: "Rup" BROAD [] synonym: "rupture through vulva" RELATED [] is_a: WBPhenotype:0000619 ! epithelial system development variant [Term] id: WBPhenotype:0000039 name: life span variant def: "Adult life span is either longer or shorter than typical of control animals." [GO:0008340, WB:cab, WB:WBPaper00005863, WB:WBPaper00026717, WB:WBPerson557] subset: phenotype_slim_wb synonym: "Age" BROAD [] synonym: "life span abnormal" NARROW [] synonym: "longevity abnormal" RELATED [] is_a: WBPhenotype:0000576 ! organism physiology variant [Term] id: WBPhenotype:0000040 name: one cell arrest early emb def: "Embryos fail to divide and arrest as one-cell embryos." [WB:cab, WB:cgc5599] synonym: "catastrophic one cell arrest" RELATED [WB:cgc5599] synonym: "Emb" BROAD [] synonym: "Ocs" BROAD [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0000041 name: osmotic integrity variant def: "Any variation in the process involved in the maintenance of an internal equilibrium of water within an organism, compared to control." [GO:0030104, WB:WBPerson2021] synonym: "osmoregulation variant" RELATED [] synonym: "osmotic integrity abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0000042 name: slow embryonic development def: "The progression through stages between fertilization to hatching are temporally retarded." [WB:WBPerson712] synonym: "Sle" BROAD [] is_a: WBPhenotype:0000674 ! slow development is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000043 name: general pace of development variant def: "Variations in the progression time of an animal from pronuclei meeting to adulthood compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "general pace of development abnormal" NARROW [] is_a: WBPhenotype:0000033 ! developmental timing variant [Term] id: WBPhenotype:0000044 name: egg size defective early emb def: "Egg is smaller or larger compared to eggs of control animals." [WB:cab, WB:cgc7141] synonym: "egg size abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000037 ! egg morphology variant is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0000045 name: developmental delay postembryonic def: "The developmental progression of an animal after the embryonic stage, over time, from its formation to its mature structure is delayed compared to control." [WB:cab, WB:WBPaper00025054] is_a: WBPhenotype:0000049 ! postembryonic development variant is_a: WBPhenotype:0000848 ! developmental delay [Term] id: WBPhenotype:0000046 name: pace of P lineage defective early emb def: "More than five minutes between AB and P1 divisions." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] synonym: "pace of P lineage abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell division variant is_a: WBPhenotype:0000824 ! embryonic cell lineage variant [Term] id: WBPhenotype:0000047 name: gastrulation variant def: "Variations in the process by which the germ layers become positioned in an embryo compared to control animals. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space." [WB:WBPaper00027251, WB:WBPerson2021] synonym: "gastrulation abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000048 name: hatching variant def: "Variations in the ability of an animal to emerge from the protective egg shell compared to control animals." [GO:0035188, WB:WBPerson2021] synonym: "hatching abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000049 name: postembryonic development variant def: "Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "postembryonic development abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism development variant [Term] id: WBPhenotype:0000050 name: embryonic lethal def: "Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054] subset: phenotype_slim_wb synonym: "Emb" BROAD [] synonym: "embryonic death" RELATED [] synonym: "inviable zygote" RELATED [] is_a: WBPhenotype:0000062 ! lethal is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000051 name: embryonic terminal arrest variable emb def: "The developmental program does not continue past embryogenesis; stage of arrest is not consistent from animal to animal." [GO:0009790, WB:WBPaper00004811, WB:WBPaper00024944, WB:WBPerson712] synonym: "Emb" BROAD [] synonym: "Etv" BROAD [] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000052 name: maternal effect lethal emb def: "Lethality caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis." [WB:WBPaper00001109, WB:WBPerson2021] synonym: "Emb" BROAD [] synonym: "Mel" BROAD [] is_a: WBPhenotype:0000050 ! embryonic lethal [Term] id: WBPhenotype:0000053 name: paralyzed arrested elongation two fold def: "Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae." [WB:cab, WB:cgc1894] synonym: "active elongation arrest" RELATED [] synonym: "Pat" BROAD [] synonym: "two fold arrest" RELATED [] is_a: WBPhenotype:0000050 ! embryonic lethal is_a: WBPhenotype:0000494 ! two fold arrest [Term] id: WBPhenotype:0000054 name: larval lethal def: "The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712] subset: phenotype_slim_wb synonym: "larval death" RELATED [] synonym: "Let" BROAD [] synonym: "Lvl" BROAD [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000055 name: early larval arrest def: "Larvae arrest during early larval development. In C. elegans, this occurs during the L1 or L2 stages of larval development." [WB:cab] is_a: WBPhenotype:0000059 ! larval arrest [Term] id: WBPhenotype:0000056 name: late larval arrest def: "Larvae arrest during late larval development. In C. elegans, larval arrest occurs during the L3 or L4 stages of larval development." [WB:cab] is_a: WBPhenotype:0000059 ! larval arrest [Term] id: WBPhenotype:0000057 name: early larval lethal def: "Animals die during early larval development. In C.elegans, this occurs during the L1- L2 larval stages of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD [] is_a: WBPhenotype:0000054 ! larval lethal [Term] id: WBPhenotype:0000058 name: late larval lethal def: "Animals die during late larval development. In C. elegans, this occurs during the L3- L4 larval stages of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD [] is_a: WBPhenotype:0000054 ! larval lethal [Term] id: WBPhenotype:0000059 name: larval arrest def: "The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021] synonym: "Lva" BROAD [] is_a: WBPhenotype:0000750 ! larval development variant is_a: WBPhenotype:0001016 ! larval growth variant [Term] id: WBPhenotype:0000060 name: adult lethal def: "Premature lethality during the adult stage. When applied to large-scale RNAi screens in C. elegans, this phenotype is present in at least 10% of analyzed worms, or at least 30% in the case of rrf-3 perturbed background." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPaper00006395] subset: phenotype_slim_wb synonym: "Adl" BROAD [WB:WBPaper00004402, WB:WBPaper00005654] synonym: "Let" BROAD [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000061 name: extended life span def: "The duration of viability in the adult phase of the life-cycle surpasses that of control animals." [GO:0008340, WB:WBPerson712] synonym: "Age" BROAD [] synonym: "longevity increased" RELATED [] is_a: WBPhenotype:0000039 ! life span variant [Term] id: WBPhenotype:0000062 name: lethal def: "Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "Let" BROAD [] is_a: WBPhenotype:0000531 ! organism development variant [Term] id: WBPhenotype:0000063 name: terminal arrest variable def: "Variations that cause developmental progression to cease at different stages of the lifecycle." [WB:WBPerson2021, WB:WBPerson557] synonym: "Var" BROAD [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000064 name: sexually dimorphic lethality def: "Animals die prematurely at any stage of the life cycle in a sex dependent manner." [WB:WBPerson2021, WB:WBPerson557] synonym: "Let" RELATED [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000065 name: X0 lethal def: "XO-bearing individuals die preferentially over other animals in the population. In C.elegans, X0 animals die preferentially over XX animals." [WB:WBPerson363, WB:WBPerson712] subset: phenotype_slim_wb synonym: "Let" BROAD [] synonym: "male specific lethality" RELATED [] is_a: WBPhenotype:0000064 ! sexually dimorphic lethality [Term] id: WBPhenotype:0000066 name: XX lethal def: "XX-bearing individuals die preferentially over other animals in the population. In C.elegans, XX animals die preferentially over X0 animals." [WB:WBPerson363, WB:WBPerson712] subset: phenotype_slim_wb synonym: "hermaphrodite specific lethality" RELATED [] is_a: WBPhenotype:0000064 ! sexually dimorphic lethality [Term] id: WBPhenotype:0000067 name: organism stress response variant def: "Animals exhibit variations in response to stress stimuli compared to control animals." [GO:0006950, WB:WBPerson712] synonym: "organism stress response abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0000068 name: oxidative stress response variant def: "Any variation in the state or activity of a cell (in terms of secretion, enzyme production, gene expression, etc.) in response to high levels of reactive oxygen species, compared to control." [GO:0006979, WB:WBPerson2021, WB:WBPerson557] synonym: "oxidative stress response abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell stress response variant [Term] id: WBPhenotype:0000069 name: progeny variant def: "Any variation in the progression of the progeny of an animal at any time from its fertilization to adulthood compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "progeny abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism development variant [Term] id: WBPhenotype:0000070 name: male tail morphology variant def: "Animals exhibit variations in the structure or organization of the somatic reproductive components of the posterior segment of the male from that observed in control males. In C. elegans, this region of the male includes the terminal canals of the reproductive tract, the digestive tract, and spicule channels along with the male specific sensilla (ray, post-cloacal, hook and spicule) and extends to the tip of the acellular fan." [WB:WBPaper00027278, WB:WBPerson712] synonym: "Mab" BROAD [] synonym: "male tail morphology abnormal" NARROW [] is_a: WBPhenotype:0000073 ! tail morphology variant is_a: WBPhenotype:0001024 ! male morphology variant [Term] id: WBPhenotype:0000071 name: head morphology variant def: "Animals exhibit variations in the form, structure or composition of any portion of their anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "head morphology abnormal" NARROW [] is_a: WBPhenotype:0000582 ! organism segment morphology variant [Term] id: WBPhenotype:0000072 name: body morphology variant def: "Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "body morphology abnormal" NARROW [] is_a: WBPhenotype:0000582 ! organism segment morphology variant [Term] id: WBPhenotype:0000073 name: tail morphology variant def: "Animals exhibit variations in the form, structure or composition of any portion of the most posterior region of the body compared to control. The anterior bound of the tail is not well defined though it might range from the position of the post-deirids to the opening of the anus (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "tail morphology abnormal" NARROW [] is_a: WBPhenotype:0000582 ! organism segment morphology variant [Term] id: WBPhenotype:0000074 name: genetic pathway variant def: "Any variation in the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "genetic pathway abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism physiology variant [Term] id: WBPhenotype:0000075 name: cuticle attachment variant def: "Any variation in the attachment of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) to the outer body of an animal compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "cuticle attachment abnormal" NARROW [] is_a: WBPhenotype:0000201 ! cuticle development variant [Term] id: WBPhenotype:0000076 name: epithelial attachment variant def: "Variations in the adhesion of the layer of cells that cover the external surface of an organism which serves to protect the animal from external environment compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "epithelial attachment abnormal" NARROW [] synonym: "hypodermal attachment abnormal" RELATED [] is_a: WBPhenotype:0000608 ! epithelial system physiology variant [Term] id: WBPhenotype:0000077 name: cuticle shedding defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement." [GO:0018996] synonym: "cuticle shedding abnormal" NARROW [] is_a: WBPhenotype:0000638 ! molt defect [Term] id: WBPhenotype:0000078 name: seam cells stacked def: "The hypodermal cells, which lie along the lateral bodywall to form longitudinal stripes of epithelial cells underlying the alae, are misplaced such that they are stacked along the dorsal-ventral axis rather than forming a continuous row of adjacent cells ." [WB:WBPaper00003081] is_a: WBPhenotype:0000703 ! epithelial morphology variant [Term] id: WBPhenotype:0000079 name: branched adult alae def: "The small linear ridges running along the lateral lines of the cuticle of adults are branched as opposed to having an unbiforcated arrangement, lengthwise along the body (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001412 ! alae morphology variant [Term] id: WBPhenotype:0000080 name: no anterior pharynx def: "Animals lack the anterior portion of the pharynx." [WB:WBPerson2021, WB:WBPerson557] synonym: "Aph" BROAD [] is_a: WBPhenotype:0000115 ! anterior pharynx variant is_a: WBPhenotype:0001646 ! no pharynx [Term] id: WBPhenotype:0000081 name: L1 arrest def: "The developmental program of the animals does not continue past the first larval stage (L1)." [WB:WBPaper00003179, WB:WBPerson2021] is_a: WBPhenotype:0000055 ! early larval arrest is_a: WBPhenotype:0000751 ! L1 larval development variant [Term] id: WBPhenotype:0000082 name: L2 arrest def: "The developmental program of the animals does not continue past the second larval stage (L2)." [WB:WBPaper00003179, WB:WBPerson2021] is_a: WBPhenotype:0000055 ! early larval arrest is_a: WBPhenotype:0000752 ! L2 larval development variant is_a: WBPhenotype:0001019 ! mid larval arrest [Term] id: WBPhenotype:0000083 name: L3 arrest def: "The developmental program of the animals does not continue past the third larval stage (L3)." [WB:WBPaper00004813, WB:WBPerson2021] is_a: WBPhenotype:0000056 ! late larval arrest is_a: WBPhenotype:0000753 ! L3 larval development variant is_a: WBPhenotype:0001019 ! mid larval arrest [Term] id: WBPhenotype:0000084 name: L4 arrest def: "The developmental program of the animals does not continue past the fourth larval stage (L4)." [WB:WBPaper00003179, WB:WBPerson2021] is_a: WBPhenotype:0000056 ! late larval arrest is_a: WBPhenotype:0000754 ! L4 larval development variant [Term] id: WBPhenotype:0000085 name: swollen intestine def: "The intestinal lumen is expanded and can often be shown to be filled with bacteria." [WB:WBPaper00026641, WB:WBPerson712] is_a: WBPhenotype:0000710 ! intestinal morphology variant [Term] id: WBPhenotype:0000086 name: shrunken intestine def: "Intestine is shrunken and may appear constricted." [WB:WBPaper00005941] is_a: WBPhenotype:0000710 ! intestinal morphology variant [Term] id: WBPhenotype:0000087 name: body wall cell development variant def: "Any variation in the progression of a body wall muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "body wall cell development abnormal" NARROW [] synonym: "body wall muscle cell development abnormal" RELATED [] is_a: WBPhenotype:0000815 ! muscle cell development variant [Term] id: WBPhenotype:0000088 name: body muscle displaced def: "The arrangement of the principal muscle cell type whose contractile activity generates body motion in the nematode differs from that observed in control animals. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the bodywall (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "body wall muscle displaced" RELATED [] is_a: WBPhenotype:0000861 ! body wall muscle development variant [Term] id: WBPhenotype:0000089 name: alpha amanitin resistant def: "Animals fail to respond to the concentration of alpha amanitin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0000090 name: epidermis cuticle detached def: "Animals are deficient in the adhesion of the cuticle to the epidermal surface of the animal." [WB:WBPerson2021, WB:WBPerson557] synonym: "hypodermis detached from cuticle" RELATED [] is_a: WBPhenotype:0000075 ! cuticle attachment variant is_a: WBPhenotype:0000076 ! epithelial attachment variant [Term] id: WBPhenotype:0000091 name: epidermis muscle detached def: "The cell(s) whose principal function is to provide contractile forces, is separated from the adjacent epidermis." [WB:WBPerson2021, WB:WBPerson557] synonym: "hypodermis detached from muscle" RELATED [] is_a: WBPhenotype:0000076 ! epithelial attachment variant is_a: WBPhenotype:0000474 ! muscle attachment variant [Term] id: WBPhenotype:0000092 name: intestinal cell proliferation variant def: "Any variation in the processes that govern the expansion of intestinal cell populations compared to control." [WB:WBPerson2021] synonym: "intestinal cell proliferation abnormal" NARROW [] is_a: WBPhenotype:0000705 ! intestinal cell development variant [Term] id: WBPhenotype:0000093 name: lineage variant def: "The descendants of a particular precursor cell exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "Lin" BROAD [] synonym: "lineage abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000094 name: anus development variant def: "Any variation in the progression of the caudal opening of the rectum in the tail over time compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "anus development abnormal" NARROW [] is_a: WBPhenotype:0000617 ! alimentary system development variant [Term] id: WBPhenotype:0000095 name: M lineage variant def: "The descendants of the M precursor cell exhibit variations in developmental programs compared to their counterparts in control animals. In C. elegans the M lineage is a postembryonic mesodermal lineage." [WB:WBPerson2021] synonym: "M lineage abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000096 name: cloacal development variant def: "Variations in the progression of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) over time compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "cloacal development abnormal" NARROW [] is_a: WBPhenotype:0000617 ! alimentary system development variant [Term] id: WBPhenotype:0000097 name: AB lineage variant def: "The descendants of the AB blastomere exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPaper00001584, WB:WBPerson2021] synonym: "AB lineage abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic cell lineage variant [Term] id: WBPhenotype:0000098 name: pharyngeal intestinal valve development variant def: "Any variation in the progression of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine over time compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal intestinal valve development abnormal" NARROW [] is_a: WBPhenotype:0000617 ! alimentary system development variant [Term] id: WBPhenotype:0000099 name: P lineages variant def: "The descendants of any of the P precursor cells exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "P lineages abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000100 name: cell UV response variant def: "Cells exhibit variations in their response to ultraviolet radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "cell UV response abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell stress response variant [Term] id: WBPhenotype:0000101 name: UV induced apoptosis increased def: "Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, UV irradiation, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000100 ! cell UV response variant is_a: WBPhenotype:0000183 ! apoptosis increased [Term] id: WBPhenotype:0000102 name: presynaptic vesicle cluster variant def: "Animals display variations in the organization, accumulation or distribution of transmitter-containing membrane-bound organelles (synaptic vesicles) compared to that observed in control animals." [WB:WBPaper00027305] synonym: "presynaptic vesicle cluster abnormal" NARROW [] synonym: "synaptic vesicle cluster abnormal" RELATED [] is_a: WBPhenotype:0001321 ! presynaptic region morphology variant [Term] id: WBPhenotype:0000103 name: gut granule development variant def: "Any variation in the progression of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes over time compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "gut granule development abnormal" NARROW [] is_a: WBPhenotype:0000705 ! intestinal cell development variant [Term] id: WBPhenotype:0000104 name: cell polarity variant def: "Contents or structures of a cell are no longer restricted/localized to their typical positions within the cell." [WB:WBPaper00031356, WB:WBPerson2021, WB:WBPerson712] subset: phenotype_slim_wb synonym: "cell polarity abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000105 name: oocyte meiotic maturation variant def: "Variations in the progression of a developing oocyte, from diakinesis to metaphase (meiosis I), in response to a signal compared to control animals. Meiotic maturation is accompanied by nuclear envelope breakdown (germinal vesicle breakdown), cytoskeletal rearrangement and meiotic spindle assembly." [GO:0001556, WB:WBPaper00026997, WB:WBPerson2021] synonym: "Oma" BROAD [] synonym: "oocyte meiotic maturation abnormal" NARROW [] is_a: WBPhenotype:0000313 ! meiotic progression during oogenesis variant [Term] id: WBPhenotype:0000106 name: inhibition of oocyte maturation variant def: "Variations in the processes that negatively regulate the meiotic progression of oocytes (exit from diakinesis) in the absence of a signal compared to control animals." [WB:WBPaper00003371, WB:WBPaper00026997, WB:WBPerson2021] synonym: "inhibition of oocyte maturation abnormal" NARROW [] is_a: WBPhenotype:0000105 ! oocyte meiotic maturation variant [Term] id: WBPhenotype:0000107 name: inhibition of ovulation variant def: "Any variation that alters the control mechanisms that inhibit oocyte maturation and release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control." [GO:0060280, WB:WBPerson2021, WB:WBPerson557] synonym: "inhibition of ovulation abnormal" NARROW [] is_a: WBPhenotype:0000666 ! ovulation variant [Term] id: WBPhenotype:0000108 name: severe dumpy is_obsolete: true [Term] id: WBPhenotype:0000109 name: moderate dumpy is_obsolete: true [Term] id: WBPhenotype:0000110 name: slightly dumpy is_obsolete: true [Term] id: WBPhenotype:0000111 name: pattern of gene expression variant def: "Any variation in the cellular or subcellular distribution of a gene product compared to that observed in control animals." [WB:WBPerson2021] synonym: "pattern of gene expression abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene expression variant [Term] id: WBPhenotype:0000112 name: protein expression variant def: "Variations in the biogenesis and stability of protein molecules compared to control." [WB:WBPerson2021] synonym: "protein expression abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene expression variant [Term] id: WBPhenotype:0000113 name: RNA expression variant def: "Variations in the biogenesis and stability of any class of RNA molecules (rRNAs, miRNAs, tRNAs etc) compared to control." [WB:WBPerson2021] synonym: "RNA expression abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene expression variant [Term] id: WBPhenotype:0000114 name: mRNA expression variant def: "Variations in the biogenesis and stability of messenger RNA molecules compared to control." [GO:0050684, WB:WBPerson2021] synonym: "mRNA expression abnormal" NARROW [] is_a: WBPhenotype:0000113 ! RNA expression variant [Term] id: WBPhenotype:0000115 name: anterior pharynx variant def: "Any variation in the progression of the anterior portion of the pharynx over time compared to control. In C. elegans the anterior region includes the corpus (procorpus and metacorpus - first bulb)." [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior pharynx abnormal" NARROW [] is_a: WBPhenotype:0000707 ! pharyngeal development variant [Term] id: WBPhenotype:0000116 name: mid larval lethal def: "Animals die in between the early and late larval stages. In C. elegans, this occurs during the L2- L3 larval stages of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD [] is_a: WBPhenotype:0000054 ! larval lethal [Term] id: WBPhenotype:0000117 name: L1 lethal def: "Animals die at the L1 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD [] is_a: WBPhenotype:0000057 ! early larval lethal [Term] id: WBPhenotype:0000118 name: L2 lethal def: "L2 lethal: Animals die at the L2 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD [] is_a: WBPhenotype:0000057 ! early larval lethal is_a: WBPhenotype:0000116 ! mid larval lethal [Term] id: WBPhenotype:0000119 name: protein expression increased def: "Any change that results in higher than normal levels of protein expression compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001400 ! level of protein expression variant [Term] id: WBPhenotype:0000120 name: protein expression reduced def: "Any change that results in lower than normal levels of protein expression compared to control animals." [WB:kmva] is_a: WBPhenotype:0001400 ! level of protein expression variant [Term] id: WBPhenotype:0000121 name: translation variant def: "Variations in the chemical reactions and pathways resulting in the formation of a protein, compared to control." [GO:0006412, WB:WBPerson2021] synonym: "protein synthesis abnormal" RELATED [] synonym: "translation abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein expression variant [Term] id: WBPhenotype:0000122 name: post translational processing variant def: "Any variation in the posttranslational modification of a protein (which may include cleavage of peptide bonds) leading to the attainment of the full functional capacity of the protein compared to control." [GO:0016485, WB:WBPerson2021, WB:WBPerson557] synonym: "post translational processing abnormal" NARROW [] synonym: "protein processing variant" RELATED [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0000123 name: enzyme expression level reduced def: "Variations that cause a decrease in the expression level of a biological catalyst, compared to control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein expression reduced [Term] id: WBPhenotype:0000124 name: enzyme activity reduced def: "Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000727 ! enzyme activity variant [Term] id: WBPhenotype:0000125 name: enzyme activity increased def: "Any variation that results in an increase in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000727 ! enzyme activity variant [Term] id: WBPhenotype:0000126 name: general pace of development defective early emb def: "Variations in the time from pronuclei meeting to furrow initiation during the first cell division compared to control animals." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] synonym: "general pace of development abnormal" NARROW [] is_a: WBPhenotype:0000043 ! general pace of development variant [Term] id: WBPhenotype:0000127 name: dauer recovery variant def: "Characteristic exit from the dauer stage is altered compared to control animals." [WB:cab] synonym: "dauer recovery abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer arrest variant [Term] id: WBPhenotype:0000128 name: temperature induced dauer formation increased def: "Animals are more likely to form dauers at temperatures that do not induce dauer entry in control animals." [WB:cgc424] synonym: "Hid" BROAD [] is_a: WBPhenotype:0000639 ! temperature induced dauer formation variant [Term] id: WBPhenotype:0000129 name: temperature induced dauer formation defective def: "Animals do not enter dauer at a temperature that induces dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000013 ! dauer defective is_a: WBPhenotype:0000639 ! temperature induced dauer formation variant [Term] id: WBPhenotype:0000130 name: pheromone induced dauer formation enhanced def: "Animals enter the dauer stage when exposed to lower concentrations or shorter exposure times of chemicals that induce dauer formation compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000132 ! pheromone induced dauer formation variant [Term] id: WBPhenotype:0000131 name: pheromone induced dauer formation defective def: "Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000013 ! dauer defective is_a: WBPhenotype:0000132 ! pheromone induced dauer formation variant [Term] id: WBPhenotype:0000132 name: pheromone induced dauer formation variant def: "Animals exhibit variations in the entry into the dauer stage when exposed to concentrations of chemicals that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "pheromone induced dauer formation abnormal" NARROW [] is_a: WBPhenotype:0001539 ! dauer induction variant [Term] id: WBPhenotype:0000133 name: expression lipogenic enzyme reduced def: "The levels of an enzyme involved in the manufacture of lipids are decreased compared to control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000123 ! enzyme expression level reduced [Term] id: WBPhenotype:0000134 name: gene expression level reduced def: "Animals exhibit a decrease in the intensity of expression of a gene product compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene expression variant [Term] id: WBPhenotype:0000135 name: gene expression level high def: "Animals exhibit an increase in the intensity of expression of a gene product compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene expression variant [Term] id: WBPhenotype:0000136 name: mRNA levels increased def: "Animals exhibit elevated levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021] is_a: WBPhenotype:0000114 ! mRNA expression variant [Term] id: WBPhenotype:0000137 name: mRNA levels reduced def: "Animals exhibit decreased levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021] is_a: WBPhenotype:0000114 ! mRNA expression variant [Term] id: WBPhenotype:0000138 name: lipid composition variant def: "The constituent parts or ratio of elements that make up lipids are altered when compared to that of control animals." [WB:WBPerson712] synonym: "fat composition abnormal" RELATED [] synonym: "fatty acid composition abnormal" RELATED [] synonym: "lipid composition abnormal" NARROW [] is_a: WBPhenotype:0000725 ! lipid metabolism variant [Term] id: WBPhenotype:0000139 name: stress induced lethality variant def: "Animals exhibit variations in survival when exposed to stress stimuli that induce lethality in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "stress induced lethality abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000140 name: stress induced arrest variant def: "Animals exhibit variations in cessation of development when exposed to stress stimuli that induce developmental arrest in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "stress induced arrest abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000141 name: stress induced lethality increased def: "Animal populations exhibit a further decrease in survival when exposed to stress stimuli compared to the lethality rate observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000139 ! stress induced lethality variant [Term] id: WBPhenotype:0000142 name: cell stress response variant def: "Variations in the activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress, compared to control. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GO:0033554, WB:WBPerson2021] synonym: "cell stress response abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0000143 name: organism UV response variant def: "Animals exhibit variations in their response to ultraviolet radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "organism UV response abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000144 name: pathogen induced cell death increased def: "Animals exhibit an increase in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000142 ! cell stress response variant is_a: WBPhenotype:0001269 ! pathogen induced cell death variant [Term] id: WBPhenotype:0000145 name: fertility variant def: "Animals exhibit variations in the time of onset or duration of the fertile period, or production of new individuals that contain some portion of their genetic material inherited from that organism compared to control." [GO:0000003, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "fertility abnormal" NARROW [] is_a: WBPhenotype:0000613 ! reproductive system physiology variant [Term] id: WBPhenotype:0000146 name: organism temperature response variant def: "Animals do not respond to changes in temperature or thermal stress in the same manner as control animals. In C.elegans this is often measured by changes in the expression of stress proteins or changes in life span." [WB:WBPerson712] synonym: "organism temperature response abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000147 name: organism starvation response variant def: "Any variation in the state or activity of an organism as a result of deprivation of nourishment, compared to control." [GO:0042594, WB:WBPerson2021] synonym: "organism starvation response abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000148 name: starvation induced dauer formation variant def: "Animals exhibit variations in the entry into the dauer stage when exposed to nutrient poor conditions that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "starvation induced dauer formation abnormal" NARROW [] is_a: WBPhenotype:0000147 ! organism starvation response variant is_a: WBPhenotype:0001539 ! dauer induction variant [Term] id: WBPhenotype:0000149 name: starvation induced dauer formation increased def: "Animals are more likely to form dauers under nutrient conditions that do not induce dauer entry in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000148 ! starvation induced dauer formation variant [Term] id: WBPhenotype:0000150 name: starvation induced dauer formation defective def: "Animals do not enter dauer under nutrient-poor conditions that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000013 ! dauer defective is_a: WBPhenotype:0000148 ! starvation induced dauer formation variant [Term] id: WBPhenotype:0000151 name: anterior pharynx extra cells def: "Embryos generate an excess number of anterior derived pharyngeal cells. In C. elegans, embryos generate an excess number of AB blastomere-derived pharyngeal cells. This hyperinduction of anterior pharyngeal tissue is associated with defects in fate specification of the ABp blastomere." [WB:WBPaper00001930, WB:WBPerson2021] synonym: "Apx " BROAD [] is_a: WBPhenotype:0000115 ! anterior pharynx variant [Term] id: WBPhenotype:0000152 name: no cleavage furrow first division early emb def: "One-cell embryos do not form the shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [GO:0032154, WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb [Term] id: WBPhenotype:0000153 name: body wall contraction variant def: "Initiation, strength, extent or cessation of body wall muscle activity that results in the shortening of the muscle, is aberrant compared to control animals." [WB:WBPaper00032190, WB:WBPerson712] synonym: "body wall contraction abnormal" NARROW [] synonym: "body wall muscle contraction abnormal" RELATED [] is_a: WBPhenotype:0000596 ! body behavior variant [Term] id: WBPhenotype:0000154 name: reduced brood size def: "The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557] is_a: WBPhenotype:0000673 ! brood size variant [Term] id: WBPhenotype:0000155 name: cell polarity reversed def: "Contents or structures of the cell are oriented on the opposite side of the cell compared to control animals; In C. elegans, this can result in the fate pattern of descendants being flipped." [WB:WBPaper00031356, WB:WBPerson2021, WB:WBPerson712] is_a: WBPhenotype:0000104 ! cell polarity variant [Term] id: WBPhenotype:0000156 name: body wall contraction interval variant def: "Any variation in the time interval between successive contractions of the body wall muscles during the defecation motor program compared to cantrol." [WB:WBPerson2021, WB:WBPerson557] synonym: "body wall contraction interval abnormal" NARROW [] synonym: "body wall muscle contraction interval abnormal" RELATED [] is_a: WBPhenotype:0000210 ! defecation contraction variant [Term] id: WBPhenotype:0000157 name: posterior body wall contraction defecation cycle variant def: "Animals exhibit variations in the sustained posterior body muscle contractions that precede the remaining contractions of the defecation cycle compared to control animals." [WB:WBPaper00031426, WB:WBPerson712] synonym: "pBoc" BROAD [] synonym: "posterior body contraction abnormal" RELATED [] synonym: "posterior body wall contraction abnormal" NARROW [] synonym: "posterior body wall contraction defective" RELATED [] is_a: WBPhenotype:0000210 ! defecation contraction variant [Term] id: WBPhenotype:0000159 name: dauer arrest variant def: "Animals exhibit variations in the entry/exit into a state of arrested tissue development during the dauer larval stage in response to harsh environmental conditions, compared to control. In C. elegans, the dauer larva enters a state of arrest in which no developmental changes occur, until the animal finds more suitable growing conditions, or until it spontaneously shifts back into a normal developmental schedule. (WormAtlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer arrest abnormal" NARROW [] synonym: "diapause variant" RELATED [] is_a: WBPhenotype:0000576 ! organism physiology variant [Term] id: WBPhenotype:0000160 name: cleavage furrow not discrete early emb def: "Embryos do not form a defined shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [GO:0032154, WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb [Term] id: WBPhenotype:0000161 name: nuclear rotation variant def: "Any variation in the rotation of centrosomes and associated pronuclei in one-cell embryo, occurring as a transition between pronuclear migration and pronuclear fusion compared to control." [GO:0035047, WB:WBPerson2021, WB:WBPerson557] synonym: "nuclear rotation abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000162 name: pale larva def: "Larva show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557] synonym: "translucent" RELATED [] is_a: WBPhenotype:0000890 ! larval pigmentation variant is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000163 name: clear larva def: "Larva appear unusually transparent when compared to control." [WB:WBPerson557] synonym: "Clr" BROAD [] synonym: "transparent" RELATED [] is_a: WBPhenotype:0000890 ! larval pigmentation variant is_a: WBPhenotype:0001010 ! clear [Term] id: WBPhenotype:0000164 name: thin def: "Animals exhibit a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson712] synonym: "slim" RELATED [] is_a: WBPhenotype:0001727 ! body width variant [Term] id: WBPhenotype:0000165 name: cell fusion variant def: "Variations in the ability of two or more individual cells to form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes. Cell fusion is dependent on the merging of lipid bilayer membranes as well as cytoplasmic mixing." [GO:0000768, GO:0045026, WB:WBPaper00005122, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell fusion abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000166 name: seam cell fusion variant def: "Variations in the ability of seam cells to fuse to form a continuous syncytium along the bodywall late larval development, (separate from the hyp 7 syncytium), compared to control (WormAtlas). Hypodermal seam cells lie along the lateral bodywall to form longitudinal stripes of epithelial cells underlying the alae, and are required for alae formation." [WB:WBPerson2021, WB:WBPerson557] synonym: "seam cell fusion abnormal" NARROW [] is_a: WBPhenotype:0000165 ! cell fusion variant [Term] id: WBPhenotype:0000167 name: precocious seam cell fusion def: "Seam cells fuse to form a continuous syncytium along the bodywall at an earlier stage of development compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000166 ! seam cell fusion variant is_a: WBPhenotype:0001433 ! precocious cell fusion [Term] id: WBPhenotype:0000168 name: alae secretion variant def: "Variations in the regulated release of proteins needed for alae formation by epidermal seam cells compared to control. Alae are small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (WormAtlas)." [WB:WBPaper00004833, WB:WBPaper00025242, WB:WBPerson2021] synonym: "alae formation variant" RELATED [] synonym: "alae secretion abnormal" NARROW [] is_a: WBPhenotype:0000258 ! cell secretion variant [Term] id: WBPhenotype:0000169 name: early exit cell cycle def: "Cells leave the M phase (mitosis and cytokinesis) at an earlier time than sister or other control cells." [GO:0010458, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0001995 ! cell cycle progression variant [Term] id: WBPhenotype:0000170 name: precocious alae def: "Formation of alae occurs earlier in development compared to control animals; In C. elegans, adult lateral alae are typically generated during the late L4 stage." [pmid:3428573, WB:cab] is_a: WBPhenotype:0000168 ! alae secretion variant is_a: WBPhenotype:0000439 ! precocious heterochronic variations [Term] id: WBPhenotype:0000171 name: cell proliferation variant def: "Any aberrancy in the processes that govern expansion of cell populations compared to control animals." [GO:0008283, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell proliferation abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000172 name: cell proliferation increased def: "The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are increased." [WB:WBPerson2021] is_a: WBPhenotype:0000171 ! cell proliferation variant [Term] id: WBPhenotype:0000173 name: cell proliferation reduced def: "The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are decreased." [WB:WBPerson2021] is_a: WBPhenotype:0000171 ! cell proliferation variant [Term] id: WBPhenotype:0000174 name: basal lamina development variant def: "Any variation in the progression of the layer of connective tissue over the surface of tissues that serves to separate it from neighboring tissues, from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "basal lamina development abnormal" NARROW [] is_a: WBPhenotype:0000619 ! epithelial system development variant [Term] id: WBPhenotype:0000175 name: hypercontracted def: "Excessive and often uncoordinated body wall muscle contraction leading to shortening of the body." [WB:WBPerson363] is_a: WBPhenotype:0000001 ! body posture variant [Term] id: WBPhenotype:0000176 name: satiety behavior variant def: "Any variation in the specific actions or reactions of an animal after completion of feeding, typically after a fast, compared to that observed in control animals. In C. elegans worms become behaviorally quiescent and cease feeding and moving when sated." [WB:WBPerson2021, WB:WBPerson557] synonym: "satiety behavior abnormal" NARROW [] is_a: WBPhenotype:0000659 ! feeding behavior variant [Term] id: WBPhenotype:0000177 name: acetylcholinesterase reduced def: "Any variation that results in a decrease of acetylcholine esterase levels, compared to control." [WB:WBPaper00024452, WB:WBPerson2021] is_a: WBPhenotype:0000124 ! enzyme activity reduced [Term] id: WBPhenotype:0000178 name: cell degeneration def: "Cells are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [WB:WBPerson712] is_a: WBPhenotype:0000729 ! cell death variant [Term] id: WBPhenotype:0000179 name: neuron degeneration def: "Cells specialized for receiving, conducting and transmitting impulses in the nervous system are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles." [WB:WBPerson712] is_a: WBPhenotype:0000178 ! cell degeneration [Term] id: WBPhenotype:0000180 name: axon morphology variant def: "Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals." [GO:0030424, WB:WBPaper00005236, WB:WBPerson712] synonym: "axon morphology abnormal" NARROW [] is_a: WBPhenotype:0001398 ! neurite morphology variant [Term] id: WBPhenotype:0000181 name: axon trajectory variant def: "Animals display variations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in control animals." [WB:WBPaper00001105, WB:WBPerson712] synonym: "axon trajectory abnormal" NARROW [] is_a: WBPhenotype:0000180 ! axon morphology variant [Term] id: WBPhenotype:0000182 name: apoptosis reduced def: "Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals." [GO:0043065, WB:WBPerson2021] is_a: WBPhenotype:0000730 ! apoptosis variant [Term] id: WBPhenotype:0000183 name: apoptosis increased def: "Any perturbation that causes an elevation in the frequency of cell death by apoptosis compared to control animals." [GO:0043066, WB:WBPerson2021] is_a: WBPhenotype:0000730 ! apoptosis variant [Term] id: WBPhenotype:0000184 name: apoptosis fails to occur def: "Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes." [WB:WBPerson712] is_a: WBPhenotype:0000182 ! apoptosis reduced [Term] id: WBPhenotype:0000185 name: apoptosis protracted def: "Animals exhibit a decreased pace of the programmed cell death pathway, compared to that observed for control cells." [WB:WBPerson712] is_a: WBPhenotype:0000730 ! apoptosis variant [Term] id: WBPhenotype:0000186 name: oogenesis variant def: "Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals." [GO:0048477, WB:WBPerson2021] synonym: "oocyte development abnormal" RELATED [] synonym: "oocyte germ cell differentiation abnormal" EXACT [] synonym: "oogenesis abnormal" NARROW [] is_a: WBPhenotype:0000894 ! germ cell differentiation variant [Term] id: WBPhenotype:0000187 name: egg round def: "The overall structure or appearance of fertilized oocytes that are laid has every part of their surface equidistant from the center." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000037 ! egg morphology variant [Term] id: WBPhenotype:0000188 name: gonad arm morphology variant def: "Any variation in the 'arm-like' form, structure or composition of the specialized tissue of the reproductive tract that produces gametes compared to control. In C. elegans the reproductive tract in the hermaphrodite has two equivalent gonad 'arms', while the male has a one-armed gonad." [WB:WBPerson2021, WB:WBPerson557] synonym: "gonad arm morphology abnormal" NARROW [] is_a: WBPhenotype:0000977 ! somatic gonad morphology variant [Term] id: WBPhenotype:0000189 name: hypodermis disorganized def: "Hypodermal cells fail to be organized in the same manner as observed in control animals. In C. elegans, hypodermal cells typically organize into distinct dorsal, lateral and ventral rows and cover the entire body." [WB:WBPaper00027006, WB:WBPerson2021] is_a: WBPhenotype:0000703 ! epithelial morphology variant [Term] id: WBPhenotype:0000190 name: no dauer recovery def: "Animals fail to exit from the facultative diapause of the dauer larval stage of nematode development." [GO:0043054, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000127 ! dauer recovery variant [Term] id: WBPhenotype:0000191 name: organism crowding response variant def: "Animals exhibit variations in their response to a situation when there is too high a density of nematodes to be supported by the available amount of food and space compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism crowding response abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000192 name: constitutive enzyme activity def: "Any variation that results in the misregulation of enzymatic activity such that catalysis occurs at a constant rate regardless of physiological demand or the concentration of a substrate." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000125 ! enzyme activity increased [Term] id: WBPhenotype:0000193 name: dominant negative enzyme def: "Any variation within an enzyme that causes it to act antagonistically towards the wild-type enzymatic product. These mutations usually result in an altered molecular function (often inactive) and are characterized by a dominant or semi-dominant phenotype." [WB:WBPerson2021] is_a: WBPhenotype:0000727 ! enzyme activity variant [Term] id: WBPhenotype:0000194 name: first polar body position variant def: "Variations in the placement of the polar body formed in the first division of meiosis of a primary oocyte, compared to control. A polar body is the by-product of meiosis (destined to degenerate) in female or hermaphrodite animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "first polar body position abnormal" NARROW [] is_a: WBPhenotype:0000775 ! meiosis variant [Term] id: WBPhenotype:0000195 name: distal tip cell migration variant def: " Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern." [GO:0040039, WB:WBPaper00003598, WB:WBPerson2021] synonym: "distal tip cell migration abnormal" NARROW [] synonym: "DTC migration abnormal" RELATED [] is_a: WBPhenotype:0000594 ! cell migration variant [Term] id: WBPhenotype:0000196 name: distal tip cell morphology variant def: "The morphological appearance of distal tip cells is varied compared to control animals." [WB:cab] synonym: "distal tip cell morphology abnormal" NARROW [] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000197 name: cell induction variant def: "Variations in a cell's ability to influence the fate of another cell (often of different developmental potential or ancestry via short range signaling)." [GO:0031128, WB:WBPerson2021] synonym: "cell induction abnormal" NARROW [] is_a: WBPhenotype:0000216 ! cell fate specification variant [Term] id: WBPhenotype:0000199 name: male tail sensory ray development variant def: "Any variation in the progression of the finger-like sensory sensilla that project from the tail and embed in the male fan from its formation to the mature structure when compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "male tail sensory ray development abnormal" NARROW [] is_a: WBPhenotype:0001008 ! male nervous system development variant [Term] id: WBPhenotype:0000200 name: pericellular component development variant def: "Variations in the progression of structures/tissues surrounding a cell over time from its initial formation to its mature form compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "pericellular component development abnormal" NARROW [] is_a: WBPhenotype:0000518 ! development variant [Term] id: WBPhenotype:0000201 name: cuticle development variant def: "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "cuticle development abnormal" NARROW [] is_a: WBPhenotype:0000200 ! pericellular component development variant [Term] id: WBPhenotype:0000202 name: alae variant def: "Any variation in the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "alae abnormal" NARROW [] is_a: WBPhenotype:0000201 ! cuticle development variant [Term] id: WBPhenotype:0000203 name: odorant adaptation variant def: "Animals exhibit variations in the characteristic desensitization to a volatile organic chemo-attractive signal in a time-concentration dependent and reversible manner compared to control animals." [WB:WBPerson2021] synonym: "odorant adaptation abnormal" NARROW [] is_a: WBPhenotype:0001048 ! odorant chemosensory response variant [Term] id: WBPhenotype:0000204 name: anterior body contraction defecation cycle variant def: "Variations in the anterior body muscle contraction (aBoc) step of the defecation cycle compared to control animals. Under normal conditions, anterior body wall muscles contract and pressurize the intestinal contents during the aBoc step." [WB:WBPerson2021] synonym: "aBoc" BROAD [] synonym: "anterior body contraction abnormal" RELATED [] synonym: "anterior body contraction defective" RELATED [] is_a: WBPhenotype:0001476 ! anterior body contraction variant [Term] id: WBPhenotype:0000205 name: expulsion variant def: "Any variation in the expulsion of gut contents compared to control. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion." [WB:WBPerson2021, WB:WBPerson557] synonym: "Exp" RELATED [] synonym: "expulsion abnormal" NARROW [] is_a: WBPhenotype:0000210 ! defecation contraction variant [Term] id: WBPhenotype:0000206 name: autosomal nondisjunction meiosis def: "A non-sex chromosome fails to segregate away from its homologous chromosome, resulting in gametes with no or extra copies of the non-sex homolog." [GO:0045143, WB:WBPerson712] is_a: WBPhenotype:0001174 ! chromosome disjunction defective [Term] id: WBPhenotype:0000207 name: defecation cycle variant def: "Any variation in the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control ." [WB:WBPerson2021, WB:WBPerson557] synonym: "Dec" RELATED [] synonym: "defecation cycle abnormal" NARROW [] is_a: WBPhenotype:0000650 ! defecation variant [Term] id: WBPhenotype:0000208 name: long defecation cycle def: "The mean time between the onset of the defecation motor program is greater than that observed for control animals." [WB:WBPaper00002315, WB:WBPaper00031896, WB:WBPerson712] synonym: "Dec-l " RELATED [] is_a: WBPhenotype:0000207 ! defecation cycle variant [Term] id: WBPhenotype:0000209 name: short defecation cycle def: "The mean time between the onset of the defecation motor program is shorter than that observed for control animals." [WB:WBPaper00002315, WB:WBPaper00031896, WB:WBPerson712] synonym: "Dec-s" RELATED [] synonym: "fast Dec" RELATED [] synonym: "posterior body wall shortened interval" EXACT [] is_a: WBPhenotype:0000207 ! defecation cycle variant [Term] id: WBPhenotype:0000210 name: defecation contraction variant def: "Any variation in the stereotyped muscle contractions that result in defecation compared to control . In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp)." [WB:WBPerson2021, WB:WBPerson557] synonym: "defecation contraction abnormal" NARROW [] is_a: WBPhenotype:0000650 ! defecation variant [Term] id: WBPhenotype:0000211 name: defecation contraction asynchronous def: "The rhythmic contractions of the muscles coordinating the elimination of gut contents are no longer synchronized compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "defecation contraction mistimed" RELATED [] is_a: WBPhenotype:0000210 ! defecation contraction variant [Term] id: WBPhenotype:0000212 name: body constriction def: "Animals contain body regions that are more narrow or drawn together than adjacent body regions." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000072 ! body morphology variant [Term] id: WBPhenotype:0000213 name: zygotic development variant def: "Variations in the progression of a zygote from formation (gamete fusion) to just prior to the first cell division compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "zygotic development abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000214 name: alpha amanitin hypersensitive def: "Animals respond to alpha amanitin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0000215 name: no germ line def: "Animals lack all germline progenitor cells, thereby resulting in the complete absence of a germline." [WB:WBPaper00001477, WB:WBPerson2021] synonym: "no germline" EXACT [] is_a: WBPhenotype:0000812 ! germ cell development variant [Term] id: WBPhenotype:0000216 name: cell fate specification variant def: "Any variation in the processes that govern acquisition of particular cell fates compared to control animals." [WB:kmva] subset: phenotype_slim_wb synonym: "cell fate specification abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000217 name: prolonged pharyngeal contraction def: "The time in which a muscle contraction event that controls feeding is increased compared to control. Contractions of the pharynx are necessary for bacterial uptake from the surrounding environment." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000980 ! pharyngeal contraction variant [Term] id: WBPhenotype:0000218 name: vulval cell induction increased def: "An excess number of vulval precursor cells receive an inductive signal leading to an increased number of VPCs adopting vulval fates compared to control animals." [WB:WBPerson2021] synonym: "Hin" BROAD [] synonym: "overinduced" NARROW [] is_a: WBPhenotype:0001272 ! vulval cell induction variant [Term] id: WBPhenotype:0000219 name: vulval cell induction reduced def: "Vulval precursor cells receive a decrease in inductive signal leading to fewer VPCs adopting vulval fates compared to control animals." [WB:WBPerson2021] synonym: "underinduced" NARROW [] is_a: WBPhenotype:0001272 ! vulval cell induction variant [Term] id: WBPhenotype:0000220 name: vulva cell fate specification variant def: "Any aberrancy in the processes that govern acquisition of vulval cell fates compared to control animals." [WB:WBPerson2021] synonym: "vulva cell fate specification abnormal" NARROW [] is_a: WBPhenotype:0000699 ! vulva development variant is_a: WBPhenotype:0002017 ! VPC competence variant [Term] id: WBPhenotype:0000221 name: neurotransmitter metabolism variant def: "Animals exhibit variations in any chemical reaction or pathway involving neurotransmitters compared to control animals. Neurotransmitters are any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GO:0042133, WB:WBPerson557, WB:WBPerson712] synonym: "neurotransmitter metabolism abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0000222 name: serotonin metabolism variant def: "Animals exhibit variations in any chemical reaction or pathway involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter, compared to control." [GO:0042428, WB:WBPerson557, WB:WBPerson712] synonym: "serotonin metabolism abnormal" NARROW [] is_a: WBPhenotype:0000221 ! neurotransmitter metabolism variant [Term] id: WBPhenotype:0000223 name: acetylcholine metabolism variant def: "Animals exhibit variations in any chemical reaction or pathway involving acetylcholine, compared to control. Acetylcholine is the acetic acid ester of the organic base choline." [GO:0008291, WB:WBPerson557, WB:WBPerson712] synonym: "acetylcholine metabolism abnormal" NARROW [] is_a: WBPhenotype:0000221 ! neurotransmitter metabolism variant [Term] id: WBPhenotype:0000224 name: serotonin deficient def: "Animals do not contain or are unable to maintain a perceivable level of serotonin capable of initiating or maintaining serotonin-dependent cell activity." [WB:WBPerson712] is_a: WBPhenotype:0000222 ! serotonin metabolism variant [Term] id: WBPhenotype:0000225 name: serotonin synthesis defective def: "Animals are unable to carry out the chemical reactions and pathways resulting in the formation of serotonin." [GO:0042427, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000222 ! serotonin metabolism variant [Term] id: WBPhenotype:0000226 name: serotonin catabolism defective def: "Animals are unable to carry out any chemical reaction or pathway resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter." [GO:0042429, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000222 ! serotonin metabolism variant [Term] id: WBPhenotype:0000227 name: male turning defective def: "The inability of a male to properly turn during mating behavior. In C. elegans, males typically turn via a sharp ventral arch of the tail, as he approaches either the hermaphrodite head or tail." [GO:0034607, WB:WBPaper00000392, WB:WBPaper00002109] synonym: "male turning abnormal" NARROW [] is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant [Term] id: WBPhenotype:0000228 name: spontaneous mutation rate increased def: "Animals accumulate a greater number of genetic lesions than control animals in the absence of an externally controlled mutagen. In C. elegans, this is often measured by observing the number of reversion events of a known mutant gene function over a couple generations." [WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0000229 name: small def: "Animals are shorter and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31] synonym: "body size reduced" EXACT [] synonym: "Sma" RELATED [] is_a: WBPhenotype:0001726 ! body length variant is_a: WBPhenotype:0001727 ! body width variant [Term] id: WBPhenotype:0000230 name: tail withered def: "The girth of the region posterior to the vulva is reduced compared to that anterior to the vulva (the Wit phenotype). In C. elegans this phenotype is associated with anteriorward misplacement of the CAN neurons." [WB:WBPaper00002795, WB:WBPerson2021, WB:WBPerson557] synonym: "Wit" RELATED [] is_a: WBPhenotype:0000073 ! tail morphology variant [Term] id: WBPhenotype:0000231 name: body size variant def: "Animals exhibit variations in the physical dimensions of its body compared to control animals of the same developmental stage." [WB:WBPerson712] comment: PATO:0000117. synonym: "body size abnormal" NARROW [] is_a: WBPhenotype:0000072 ! body morphology variant [Term] id: WBPhenotype:0000232 name: CAN cell migration variant def: "Variation in the migration pattern of CAN neurons. In C. elegans, CAN neurons move posteriorly from their birthplace in the head to positions near the middle of the embryo." [WB:WBPaper00002795, WB:WBPerson2021] synonym: "CAN cell migration abnormal" NARROW [] is_a: WBPhenotype:0001520 ! posterior neuron migration variant [Term] id: WBPhenotype:0000233 name: dopamine metabolism variant def: "Animals exhibit variations in any chemical reaction or pathway involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline, compared to control." [GO:0042417, WB:WBPerson557, WB:WBPerson712] synonym: "dopamine metabolism abnormal" NARROW [] is_a: WBPhenotype:0000221 ! neurotransmitter metabolism variant is_a: WBPhenotype:0001518 ! biogenic amine physiology variant [Term] id: WBPhenotype:0000234 name: dopamine deficient def: "Animals do not contain or are unable to maintain a perceivable level of dopamine capable of initiating or maintaining dopamine-dependent cell activity." [WB:WBPerson712] is_a: WBPhenotype:0000233 ! dopamine metabolism variant [Term] id: WBPhenotype:0000235 name: dopamine synthesis defective def: "Animals are unable to carry out the chemical reactions and pathways resulting in the formation of dopamine." [GO:0042416, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000233 ! dopamine metabolism variant [Term] id: WBPhenotype:0000236 name: dopamine catabolism defective def: "Animals are unable to carry outany chemical reaction or pathway resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GO:0042420, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000233 ! dopamine metabolism variant [Term] id: WBPhenotype:0000237 name: foraging hyperactive def: "Animals extend intensity of roaming and or dwelling activity compared to control animals. In C. elegans, hyperactivity may include an increase in nose-lifts per minute." [WB:WBPaper00031455, WB:WBPaper00031570, WB:WBPerson712] is_a: WBPhenotype:0000662 ! foraging behavior variant [Term] id: WBPhenotype:0000238 name: foraging reduced def: "Animals decrease intensity or rate of roaming and or dwelling activity compared to control animals." [WB:WBPaper00031455, WB:WBPerson712] is_a: WBPhenotype:0000662 ! foraging behavior variant [Term] id: WBPhenotype:0000239 name: vulval cell lineage variant def: "The descendants of a vulval precursor cell exhibit altered developmental programs compared to their counterparts in control animals. In C. elegans, the VPCs are P3.p-P8.p." [WB:WBPaper00005610, WB:WBPerson2021] synonym: "VPC lineage abnormal" RELATED [] synonym: "vulval cell lineage abnormal" NARROW [] is_a: WBPhenotype:0000099 ! P lineages variant [Term] id: WBPhenotype:0000240 name: blast cell proliferation reduced def: "The processes governing the expansion of blast cell populations vary, such that cell populations are decreased compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000173 ! cell proliferation reduced [Term] id: WBPhenotype:0000241 name: accumulated cell corpses def: "Animals exhibit an increase in the quantity of cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712] is_a: WBPhenotype:0000590 ! cell corpse number variant [Term] id: WBPhenotype:0000242 name: body elongation defective def: "The epidermal cells of the embryo fail to elongate. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm." [WB:WBPerson2021] is_a: WBPhenotype:0001478 ! body elongation variant [Term] id: WBPhenotype:0000243 name: engulfment failure by killer def: "Removal of cell corpses through a dedicated engulfment pathway is defective." [WB:WBPerson712] is_a: WBPhenotype:0000885 ! engulfment variant [Term] id: WBPhenotype:0000244 name: apoptotic arrest def: "Cells fail to complete the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes." [WB:WBPerson712] synonym: "apoptosis block" RELATED [] is_a: WBPhenotype:0000730 ! apoptosis variant [Term] id: WBPhenotype:0000245 name: SM migration variant def: "Variations in the movement of sex myoblasts compared to control animals. In C. elegans, the larval SM migrate anteriorly to the precise center of the developing hermaphrodite gonad." [WB:WBPaper00003627, WB:WBPerson2021] synonym: "SM migration abnormal" NARROW [] is_a: WBPhenotype:0001230 ! anterior cell migration defective [Term] id: WBPhenotype:0000246 name: defecation cycle variable length def: "Animals exhibit variation in the time of onset of the defecation motor program significantly greater than that observed for control animals." [WB:WBPaper00031896, WB:WBPerson712] is_a: WBPhenotype:0000207 ! defecation cycle variant [Term] id: WBPhenotype:0000247 name: sodium chemotaxis defective def: "Failure to execute the characteristic response to sodium as defined by control animals. In C. elegans, sodium is typically an attractant." [WB:cab, WB:cgc387] synonym: "Na chemotaxis defective" RELATED [] synonym: "sodium acetate chemotaxis defective" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001440 ! cation positive chemotaxis defective [Term] id: WBPhenotype:0000248 name: sensory neuroanatomy variant synonym: "sensory neuroanatomy abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000249 name: osmotic avoidance defective def: "Failure to execute the characteristic avoidance response to solutions of high osmotic strength as defined by control animals." [WB:cab, WB:WBPerson2021] is_a: WBPhenotype:0000663 ! osmotic avoidance variant [Term] id: WBPhenotype:0000250 name: octopamine metabolism variant def: "Animals exhibit variations in any chemical reaction or pathway involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol, compared to control." [GO:0046333, WB:WBPerson557, WB:WBPerson712] synonym: "octopamine metabolism abnormal" NARROW [] is_a: WBPhenotype:0000221 ! neurotransmitter metabolism variant is_a: WBPhenotype:0001518 ! biogenic amine physiology variant [Term] id: WBPhenotype:0000251 name: octopamine deficient def: "Animals do not contain or are unable to maintain a perceivable level of octopamine capable of initiating or maintaining dopamine-dependent cell activity." [WB:WBPerson712] is_a: WBPhenotype:0000250 ! octopamine metabolism variant [Term] id: WBPhenotype:0000252 name: caffeine resistant def: "Animals fail to respond to the concentration of caffeine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0000253 name: movement erratic def: "Animals exhibit a lack of consistency, regularity, or uniformity while traveling from one location to another." [WB:WBPerson2021, WB:WBPerson557] synonym: "movement irregular" RELATED [] is_a: WBPhenotype:0001701 ! spastic locomotion [Term] id: WBPhenotype:0000254 name: chloride chemotaxis defective def: "Failure to execute the characteristic response to chloride. In C. elegans, chloride is typically an attractant." [WB:cab, WB:cgc387] synonym: "Cl chemotaxis defective" RELATED [] is_a: WBPhenotype:0001439 ! anion positive chemotaxis defective is_a: WBPhenotype:0001458 ! chloride chemotaxis variant [Term] id: WBPhenotype:0000255 name: amphid phasmid morphology variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid and phasmid sensilla from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000938] comment: WBbt:0005394, WBbt:0006753. synonym: "amphid phasmid morphology abnormal" NARROW [] synonym: "dye filling defect" RELATED [] synonym: "Dyf" BROAD [] is_a: WBPhenotype:0001527 ! amphid phasmid sensillum morphology variant [Term] id: WBPhenotype:0000256 name: amphid morphology variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000938] comment: WBbt:0005394. synonym: "amphid morphology abnormal" NARROW [] is_a: WBPhenotype:0000255 ! amphid phasmid morphology variant [Term] id: WBPhenotype:0000257 name: phasmid morphology variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the phasmid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000938] comment: WBbt:0006753. synonym: "phasmid morphology abnormal" NARROW [] is_a: WBPhenotype:0000255 ! amphid phasmid morphology variant [Term] id: WBPhenotype:0000258 name: cell secretion variant def: "Variations in the regulated release of substances by a cell compared to control." [GO:0032940, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell secretion abnormal" NARROW [] synonym: "cellular secretion abnormal" EXACT [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000259 name: sheath cell secretion variant def: "Variations in the regulated release of substances by nonneuronal cells that enclose or ensheath the tips of the sensory dendrites compared to control." [WB:WBPaper00000822, WB:WBPerson2021] synonym: "sheath cell secretion abnormal" NARROW [] is_a: WBPhenotype:0000258 ! cell secretion variant [Term] id: WBPhenotype:0000260 name: sheath cell secretion failure def: "The regulated release of materials by sheath cells is disrupted." [WB:WBPaper00028924, WB:WBPerson2021] is_a: WBPhenotype:0000259 ! sheath cell secretion variant [Term] id: WBPhenotype:0000261 name: amphid sheath secretion failure def: "Amphid sheath cells lack the ability to secrete vesicles and their contents within the amphid pocket." [WB:WBPaper00028924, WB:WBPerson2021] is_a: WBPhenotype:0000260 ! sheath cell secretion failure [Term] id: WBPhenotype:0000262 name: axoneme morphology variant def: "Animals exhibit variations in the structure or composition of the microtubule-based fibrillar bundle (axoneme) that makes up the core of the middle part of the cilium (in a pattern of nine doublet microtubules attached to the membrane and a variable number of smaller singlet microtubules occupying the center). In C. elegans, the axoneme microtubules are arranged in a pattern of nine doublets attached to the membrane with seven smaller singlet microtubules occupying the center." [WB:WBPaper00000932, WB:WBPerson712] synonym: "axoneme morphology abnormal" NARROW [] is_a: WBPhenotype:0000615 ! cilia morphology variant [Term] id: WBPhenotype:0000263 name: axoneme short def: "The microbule-based fibrillar bundle in the core of the cilium is reduced in length compared to axonemes of similar cells in control animals." [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000262 ! axoneme morphology variant [Term] id: WBPhenotype:0000264 name: cAMP chemotaxis defective def: "Failure to execute the characteristic response to cAMP as defined by control animals. In C. elegans, cAMP is typically an attractant." [WB:cab, WB:cgc387, WB:WBPaper00001481, WB:WBPaper00002033] is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective is_a: WBPhenotype:0001463 ! cAMP chemotaxis variant [Term] id: WBPhenotype:0000265 name: odorant positive chemotaxis variant def: "Movement towards typically attractive volatile organic chemicals is altered as defined by control animals. In C. elegans, these odorants are typically sensed by the AWA and AWC neurons." [WB:cab, WB:cgc1786, WB:WBPerson2021] synonym: "odorant positive chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0000635 ! positive chemotaxis variant is_a: WBPhenotype:0001048 ! odorant chemosensory response variant [Term] id: WBPhenotype:0000266 name: cell cleavage variant def: "Variations that disrupt stereotypical cleavage patterns (such as cleavage rate, division axes or asymmetric division) compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "cell cleavage abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0000267 name: cell cleavage delayed def: "Any variation that causes a delay in the stereotypical cleavage event compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000266 ! cell cleavage variant is_a: WBPhenotype:0000438 ! retarded heterochronic variations [Term] id: WBPhenotype:0000268 name: P cell cleavage delayed def: "Any variation that causes a delay in the stereotypical cleavage pattern of the P cell compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000267 ! cell cleavage delayed [Term] id: WBPhenotype:0000269 name: unclassified def: "Animals display a phenotype that has not yet been assigned to a current classification." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb is_obsolete: true [Term] id: WBPhenotype:0000270 name: pleiotropic defects severe early emb def: " Seemingly unrelated variations that concurrently occur during early embryonic development compared to control animals. In C. elegans, this can include multiple pronuclei, aberrant cytoplasmic texture, decrease in overall pace of development and osmotic sensitivity." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001007 ! other abnormality early emb [Term] id: WBPhenotype:0000272 name: egg laying irregular def: "The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate does not conform to the pattern observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000640 ! egg laying variant [Term] id: WBPhenotype:0000273 name: thrashing reduced def: "The number of body thrashes within an aqueous environment in a given period of time are reduced compared with control worms." [WB:cab, WB:cgc7388] is_a: WBPhenotype:0001700 ! swimming variant [Term] id: WBPhenotype:0000274 name: dead eggs laid def: "Animals lay eggs that are inviable." [WB:cab] is_a: WBPhenotype:0000640 ! egg laying variant is_a: WBPhenotype:0000806 ! hermaphrodite fertility variant [Term] id: WBPhenotype:0000275 name: organism UV hypersensitive def: "Organisms respond to UV at a lower dose or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000143 ! organism UV response variant [Term] id: WBPhenotype:0000276 name: organism X ray response variant def: "Animals exhibit variations in their response to X-ray radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "organism X ray response abnormal" NARROW [] is_a: WBPhenotype:0000686 ! organism ionizing radiation response variant [Term] id: WBPhenotype:0000277 name: rhythm slow def: "The timing of a biological cycle that recurs with regularity is delayed compared to control." [GO:0048511, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000278 name: body region pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency or translucency of a particular body region." [WB:WBPerson557] synonym: "body region pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000521 ! pigmentation variant [Term] id: WBPhenotype:0000279 name: spicule insertion defective def: "Males exhibit defects in the insertion of the male copulatory spicules into the mating partner. In C. elegan spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [GO:0034609, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001414 ! male mating defective is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant [Term] id: WBPhenotype:0000280 name: breaks in alae def: "The small linear ridges running along the lateral lines of the cuticle, lengthwise along the body, contain gaps as opposed to a continuous arrangement (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001412 ! alae morphology variant [Term] id: WBPhenotype:0000281 name: male sex muscle development variant def: "Variations in the progression of the muscles of the adult male reproductive system over time form their initial formation to their mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "male sex muscle development abnormal" NARROW [] is_a: WBPhenotype:0000669 ! sex muscle development variant [Term] id: WBPhenotype:0000282 name: hermaphrodite sex muscle development variant def: "Variations in the progression of the muscles of the adult hermaphrodite reproductive system over time form their initial formation to their mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite sex muscle development abnormal" NARROW [] is_a: WBPhenotype:0000669 ! sex muscle development variant [Term] id: WBPhenotype:0000283 name: vulva uterus connection defective def: "Animals exhibit defects in the continuity of lumen between the vulva and uterus compared to control animals." [WB:WBPaper00003386, WB:WBPaper00006298, WB:WBPaper00027236, WB:WBPaper00027316, WB:WBPerson712] synonym: "AC block" NARROW [] is_a: WBPhenotype:0000624 ! reproductive system development variant [Term] id: WBPhenotype:0000284 name: sperm transfer defective def: "Any defect in the process whereby a male inseminates his partner by introducing sperm into the genital tract." [GO:0007320, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001414 ! male mating defective is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant [Term] id: WBPhenotype:0000285 name: ray tips swollen def: "The extreme ends of any of the finger-like sensory sensilla that project from the tail and embed in the male fan appear bloated or distended." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000505 ! male ray morphology variant [Term] id: WBPhenotype:0000286 name: embryo disorganized def: "Embryos fail to be organized in the same manner as observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000288 name: distal germline variant def: "Variations in the progression of the lineages that gives rise to all germ cells, lying in the region adjacent to the proximal gonad (on the side furthest from the founder cells of the somatic gonad), over time compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "distal germ line abnormal" RELATED [] synonym: "distal germline abnormal" NARROW [] is_a: WBPhenotype:0000812 ! germ cell development variant [Term] id: WBPhenotype:0000289 name: uterus morphology variant def: "Any variation in the form, structure or composition of the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "uterus morphology abnormal" NARROW [] is_a: WBPhenotype:0001335 ! hermaphrodite reproductive system morphology variant [Term] id: WBPhenotype:0000290 name: sperm absent def: "Animals lack fully specialized male gametes that are competent for fertilization." [WB:WBPerson2021] synonym: "no sperm" RELATED [] is_a: WBPhenotype:0000395 ! no differentiated gametes [Term] id: WBPhenotype:0000291 name: no oocytes def: "Hermaphrodites lack fully specialized female gametes that are competent for fertilization." [WB:WBPerson2021] synonym: "oocytes absent" RELATED [] is_a: WBPhenotype:0000395 ! no differentiated gametes [Term] id: WBPhenotype:0000292 name: organ system pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a organ system." [WB:WBPerson557] synonym: "organ system pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000521 ! pigmentation variant [Term] id: WBPhenotype:0000293 name: alimentary system pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the alimentary system." [WB:WBPerson557] synonym: "alimentary system pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000292 ! organ system pigmentation variant [Term] id: WBPhenotype:0000294 name: intestine dark def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that decrease the transparency/translucency of the intestine." [WB:WBPerson557] synonym: "Din" BROAD [] is_a: WBPhenotype:0000293 ! alimentary system pigmentation variant [Term] id: WBPhenotype:0000295 name: thermotolerance increased def: "Animals are able to survive for longer periods at temperatures above standard culture temperatures than control animals." [WB:WBPaper00005836, WB:WBPerson712] synonym: "intrinsic thermotolerance increased " NARROW [] is_a: WBPhenotype:0000146 ! organism temperature response variant [Term] id: WBPhenotype:0000296 name: spicules crumpled def: "The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) are deformed. In C. elegans males there are two copulatory spicules." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000443 ! spicule morphology variant [Term] id: WBPhenotype:0000297 name: rays fused def: "Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are joined to one another." [WB:WBPerson2021, WB:WBPerson557] synonym: "ray fusion" EXACT [] is_a: WBPhenotype:0000165 ! cell fusion variant is_a: WBPhenotype:0000199 ! male tail sensory ray development variant is_a: WBPhenotype:0000505 ! male ray morphology variant [Term] id: WBPhenotype:0000298 name: rays displaced def: "Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are shifted from their customary place." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000505 ! male ray morphology variant [Term] id: WBPhenotype:0000299 name: sensillum morphology variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals." [WB:WBPaper00000214, WB:WBPaper00000938, WB:WBPerson712] synonym: "chemosensory cell morphology abnormal" RELATED [] synonym: "sensillum morphology abnormal" NARROW [] is_a: WBPhenotype:0000604 ! nervous system morphology variant [Term] id: WBPhenotype:0000300 name: amphid sheath cell morphology variant def: "Animals exhibit variations in the structure or composition of the amphid sensillum cell that ensheathes the dendrite tips of channel neurons and wing cell dedritic processes, from that observed in control animals. Sheath cells in C.elegans have highly invaginated and vesiculated surfaces, which provide a specialized environment for the dendritic structures." [WB:WBPaper00000214, WB:WBPaper00000503, WB:WBPaper00000822, WB:WBPerson712] synonym: "amphid sheath cell morphology abnormal" NARROW [] is_a: WBPhenotype:0001527 ! amphid phasmid sensillum morphology variant [Term] id: WBPhenotype:0000301 name: distal tip cell reflex failure def: "A migrating distal tip cell (DTC) fails to follow the stereotypical path. In C. elegans this path is U-shaped and results in the formation of reflexed gonadal arm." [WB:WBPaper00029151, WB:WBPerson2021] is_a: WBPhenotype:0000195 ! distal tip cell migration variant [Term] id: WBPhenotype:0000302 name: benzaldehyde chemotaxis defective def: "Failure to execute the characteristic response to benzaldehyde as defined by control animals. In C.elegans benzaldehyde is typically attractive." [WB:WBPaper00001786] is_a: WBPhenotype:0001060 ! AWC odorant chemotaxis defective is_a: WBPhenotype:0001468 ! benzaldehyde chemotaxis variant [Term] id: WBPhenotype:0000303 name: diacetyl chemotaxis defective def: "Failure to execute the characteristic response to diacetyl as defined by control animals. In C.elegans diacetyl is typically attractive." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective is_a: WBPhenotype:0001470 ! diacetyl chemotaxis variant [Term] id: WBPhenotype:0000304 name: isoamyl alcohol chemotaxis defective def: "Failure to execute the characteristic response to isoamyl alcohol as defined by control animals. In C.elegans isoamyl alcohol is typically attractive." [WB:cab, WB:cgc1786] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective is_a: WBPhenotype:0001472 ! isoamyl alcohol chemotaxis variant [Term] id: WBPhenotype:0000305 name: pheromone sensation variant def: "Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that influences behavior in control animals." [GO:0043695, WB:WBPerson2021, WB:WBPerson557] synonym: "pheromone sensation abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0000306 name: transgene expression variant def: "Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "transgene expression abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene expression variant [Term] id: WBPhenotype:0000307 name: dauer pheromone sensation defective def: "Animals fail to detect a pheromone stimulus that induces dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001479 ! dauer pheromone sensation variant [Term] id: WBPhenotype:0000308 name: dauer development variant def: "Any variation in the processes that govern development of the dauer larva, a developmentally arrested, larval stage that is specialized for survival under harsh, or otherwise unfavorable, environmental conditions. In C. elegans this is an alternative third larval stage." [WB:kmva] synonym: "dauer development abnormal" NARROW [] is_a: WBPhenotype:0000049 ! postembryonic development variant [Term] id: WBPhenotype:0000309 name: SDS sensitive dauer def: "Any variation that decreases the ability of dauer larva to tolerate the exposure to sodium dodecyl sulfate (a detergent) compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0001546 ! dauer resistance to harsh conditions variant is_a: WBPhenotype:0001918 ! chemical hypersensitive [Term] id: WBPhenotype:0000310 name: cilia absent def: "Neurons lack the finger-like dendritic projections, which are observed extending from similar cells in control animals." [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000615 ! cilia morphology variant [Term] id: WBPhenotype:0000312 name: dauer pheromone production defective def: "Animals are incapable of synthesizing pheromones that induce dauer formation in control animals." [GO:0042446, WB:WBPerson2021] is_a: WBPhenotype:0000191 ! organism crowding response variant is_a: WBPhenotype:0001547 ! dauer metabolism variant [Term] id: WBPhenotype:0000313 name: meiotic progression during oogenesis variant def: "Developing oocytes show defects in their initial entry or progression through the meiotic pathway (such as failure to exit diakinesis)." [WB:WBPaper00026997, WB:WBPerson2021] synonym: "meiotic progression during oogenesis abnormal" NARROW [] is_a: WBPhenotype:0000186 ! oogenesis variant [Term] id: WBPhenotype:0000314 name: scrawny def: "Animals are slight or meager in body size compared to control animals at the same developmental stage." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000231 ! body size variant [Term] id: WBPhenotype:0000315 name: mechanosensation variant def: "Any variation with respect to perception or response to mechanical stimuli compared to control animals." [WB:cab] subset: phenotype_slim_wb synonym: "Mec" BROAD [] synonym: "mechanosensation abnormal" NARROW [] synonym: "touch response abnormal" EXACT [] is_a: WBPhenotype:0000525 ! organism behavior variant is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0000316 name: touch resistant tail def: "Failure to execute a characteristic response when struck or stroked in the posterior region. In C. elegans, animals move forward movement when struck or stroked in the posterior region, usually with a hair or similar fiber. The posterior region lies between the vulva and the tail." [WB:WBPaper00000502, WB:WBPaper00001133, WB:WBPaper00001705, WB:WBPerson557] synonym: "touch insensitive tail" RELATED [] synonym: "touch resistant posterior body" BROAD [] is_a: WBPhenotype:0000456 ! touch resistant [Term] id: WBPhenotype:0000317 name: head withdrawal defective def: "Animals are deficient in the foraging response in which an animal quickly pulls its head away from a stimulus to the nose (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000315 ! mechanosensation variant [Term] id: WBPhenotype:0000318 name: cell cycle delayed def: "Cells of the animals proceed through their replicative phase at a pace slower than observed for control cells." [WB:WBPerson712] is_a: WBPhenotype:0000438 ! retarded heterochronic variations is_a: WBPhenotype:0001995 ! cell cycle progression variant [Term] id: WBPhenotype:0000319 name: large def: "Animals have increased girth and increased length compared to control animals at the same developmental stage." [WB:WBPerson2021, WB:WBPerson557] synonym: "body size enlarged" EXACT [] is_a: WBPhenotype:0000231 ! body size variant [Term] id: WBPhenotype:0000320 name: reduced viability after freezing def: "Animals show a decrease in survivorship after thawing compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000141 ! stress induced lethality increased [Term] id: WBPhenotype:0000321 name: nose morphology variant def: "Animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "nose morphology abnormal" NARROW [] is_a: WBPhenotype:0000071 ! head morphology variant [Term] id: WBPhenotype:0000322 name: nose rounded def: "The extreme anterior part of the body appears blunted in shape." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000321 ! nose morphology variant [Term] id: WBPhenotype:0000323 name: head swollen def: "The most anterior portion of the animal appears bloated or distended." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000071 ! head morphology variant [Term] id: WBPhenotype:0000324 name: short def: "Animals exhibit a decreased body length compared to control animals of the same developmental stage." [WB:WBPerson712] is_a: WBPhenotype:0001726 ! body length variant [Term] id: WBPhenotype:0000325 name: arecoline hypersensitive def: "Animals respond to arecoline at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001579 ! cholinergic agonist hypersensitive [Term] id: WBPhenotype:0000326 name: arecoline resistant def: "Animals fail to respond to the concentration of arecoline that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001578 ! cholinergic agonist resistant [Term] id: WBPhenotype:0000327 name: corpus contraction defect def: "Any defect in the muscle contractions of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000747 ! pharyngeal contraction defective [Term] id: WBPhenotype:0000328 name: terminal bulb contraction variant def: "Variations in the rhythmic contractions of the posterior pharynx (terminal bulb), such as timing, strength etc. In C. elegans contraction of the terminal bulb inverts the grinder, allowing bacteria in front of the grinder to be broken up and transported to the intestine." [WB:WBPaper00001696] synonym: "terminal bulb contraction abnormal" NARROW [] is_a: WBPhenotype:0000980 ! pharyngeal contraction variant [Term] id: WBPhenotype:0000329 name: pumping asynchronous def: "The rhythmic contractions of pharyngeal compartments are no longer synchronized compared to control. In C. elegans the corpus and terminal bulb normally contract simultaneously." [WB:WBPaper00001696] is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant [Term] id: WBPhenotype:0000330 name: pharyngeal relaxation defective def: " Defects in rhythmic pharyngeal relaxations compared to control animals. In C. elegans pharyngeal relaxation follows a contraction event and facilitates bacterial trapping within the pharynx while expelling liquid." [WB:WBPaper00001709] is_a: WBPhenotype:0001004 ! pharyngeal relaxation variant [Term] id: WBPhenotype:0000331 name: inhibitors of na k atpase resistant def: " Animals fail to respond to the concentration of sodium potassium ATPase antagonists that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2021] synonym: "ouabain resistant" NARROW [] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0000332 name: inhibitors of sodium potassium ATPase hypersensitive def: "Animals respond to inhibitors of sodium potassium ATPase at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0000333 name: pharyngeal pumps brief def: "The time interval of the stereotyped sequence of muscle contractions by individual pharyngeal muscles that act to draw food into the pharynx is shorter compared to that observed in control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant [Term] id: WBPhenotype:0000334 name: isthmus corpus slippery def: "Failure of muscle contractions in the corpus and isthmus to trap and transport bacteria posteriorly in the pharynx." [WB:WBPaper00001696] is_a: WBPhenotype:0000335 ! pharynx slippery [Term] id: WBPhenotype:0000335 name: pharynx slippery def: "Failure of pharyngeal contractions to trap and transport bacteria posteriorly. In C. elegans this defect results in a distention of the pharyngeal lumen." [WB:WBPaper00001696] is_a: WBPhenotype:0000634 ! pharyngeal pumping variant [Term] id: WBPhenotype:0000336 name: terminal bulb relaxation variant def: "Variations in the rhythmic relaxations of the posterior pharynx (terminal bulb). In C. elegans the relaxation of the terminal bulb returns the grinder to its relaxed forward position." [WB:WBPaper00001696] synonym: "terminal bulb relaxation abnormal" NARROW [] is_a: WBPhenotype:0000330 ! pharyngeal relaxation defective [Term] id: WBPhenotype:0000337 name: grinder relaxation defective def: "Failure of the grinder to come to a full relaxed position between pumps compared to control." [WB:WBPaper00001709] is_a: WBPhenotype:0001480 ! grinder relaxation variant [Term] id: WBPhenotype:0000338 name: tail swelling def: "Swelling in the post anal region compared to control. In C. elegans this swelling can be associated with infection from the nematode-specific bacterial pathogen, Microbacterium nematophilum." [WB:cab, WB:WBPaper00026735] synonym: "Dar" BROAD [] synonym: "deformed anal region" RELATED [] is_a: WBPhenotype:0000073 ! tail morphology variant [Term] id: WBPhenotype:0000339 name: transient bloating def: "Worms sporatically appear turgid or swollen as a result of an excess number of eggs being retained in the uterus." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000862 ! bloated [Term] id: WBPhenotype:0000340 name: imipramine resistant def: "Animals fail to respond to the concentration of imipramine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant is_a: WBPhenotype:0001598 ! inhibitor of serotonin uptake variant [Term] id: WBPhenotype:0000341 name: imipramine hypersensitive def: "Animals respond to imipramine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0000342 name: bursa morphology variant def: "Any variation in the form, structure or composition of the adult male tail including the lateral fan and rays compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "bursa morphology abnormal" NARROW [] is_a: WBPhenotype:0000070 ! male tail morphology variant [Term] id: WBPhenotype:0000344 name: cloacal structures protrude def: "Any of the contents that comprise the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus extend into the external environment through the cloacal opening." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000908 ! cloacal morphology variant [Term] id: WBPhenotype:0000345 name: VPC cell division variant def: "Any variation that alters the physical partitioning and separation of a vulval precursor cell into daughter cells compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "VPC cell division abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0000346 name: adult pigmentation variant def: "Adult animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals." [WB:WBPerson557] synonym: "adult pigmentation abnormal" NARROW [] is_a: WBPhenotype:0001009 ! developmental pigmentation variant [Term] id: WBPhenotype:0000347 name: rectal development variant def: "Any variation in the progression of the cuticle-lined sinus opening on the posterior ventral surface of the animal over time from its formation to its mature structure compared to control (Wormatlas). The function of the rectum is to excrete waste products from the alimentary system." [WB:WBPerson2021, WB:WBPerson557] synonym: "rectal development abnormal" NARROW [] is_a: WBPhenotype:0000617 ! alimentary system development variant [Term] id: WBPhenotype:0000349 name: flaccid def: "A semi-paralysed body phenotype in which muscle tone is lost and the animal fails to actively control its body shape (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "floppy" RELATED [] synonym: "limp" RELATED [] is_a: WBPhenotype:0000001 ! body posture variant [Term] id: WBPhenotype:0000350 name: hermaphrodite tail spike variant def: "Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the hermaphrodite tail compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000968 ! tail spike variant [Term] id: WBPhenotype:0000351 name: failure to hatch def: "Animals fail to emerge from an egg shell." [GO:0035188, WB:WBPerson2021] is_a: WBPhenotype:0000048 ! hatching variant is_a: WBPhenotype:0000050 ! embryonic lethal [Term] id: WBPhenotype:0000352 name: backing uncoordinated def: "Backward movement is not coordinated as in control. This often causes jerky or spastic backward locomotion." [WB:WBPaper00001709] is_a: WBPhenotype:0001005 ! backward locomotion variant [Term] id: WBPhenotype:0000353 name: backing increased def: "Animals spend more time backing compared to control animals." [WB:cab] is_a: WBPhenotype:0001005 ! backward locomotion variant [Term] id: WBPhenotype:0000354 name: cell differentiation variant def: "Variations in the processes leading to the specialization of cell. Differentiation impacts diverse cellular properties such as size, shape, polarity, gene expression and responsiveness to signals/cues." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell differentiation abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000355 name: HSN differentiation precocious def: "Specialization of HSN precursor cells to mature HSN neurons occurs at an earlier stage of development compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000354 ! cell differentiation variant is_a: WBPhenotype:0000439 ! precocious heterochronic variations [Term] id: WBPhenotype:0000356 name: spermatogenesis delayed def: "The progression of immature germ cells to functional sperm is retarded compared to control." [WB:WBPaper00005566, WB:WBPerson2021] is_a: WBPhenotype:0000438 ! retarded heterochronic variations is_a: WBPhenotype:0000670 ! spermatogenesis variant [Term] id: WBPhenotype:0000357 name: unfertilized oocytes laid def: "Animals lay inactivated oocytes. In C elegans this may be due to perturbations that eliminate spermatogenesis or result in the production of defective sperm." [WB:WBPaper00001075, WB:WBPerson2021] is_a: WBPhenotype:0000640 ! egg laying variant [Term] id: WBPhenotype:0000358 name: extra cell division postembryonic def: "Animals execute supernumerary cell divisions post-hatching." [WB:WBPerson2021, WB:WBPerson557] synonym: "supernumerary cell divisions" RELATED [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000359 name: tunicamycin response variant def: "Animals exhibit variations in the response to the addition of tunicamycin compared to that observed in control animals. Tunicamycin induces the unfolded protein response." [WB:WBPaper00030877, WB:WBperson557] synonym: "tunicamycin response abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0000360 name: cytoplasmic streaming defective def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is impaired." [GO:0016482, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000361 name: lima bean arrest def: "Cessation of development at an intermediate stage in embryogenesis, immediately following the completion of gastrulation. In C. elegans this occurs around 350-390 minutes after first cleavage, cell number is at approximately 560 cells. At this time cell proliferation ceases and the embryo begins morphogenesis and elongation. The shape of the entire embryo within the eggshell resembles a lima bean (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "arrest during epiboly" RELATED [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000867 ! embryonic arrest [Term] id: WBPhenotype:0000362 name: blastocoel variant def: "Any variation in the progression of the fluid-filled compartment inside the developing embryo at the onset of gastrulation over time from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "blastocoel abnormal" NARROW [] is_a: WBPhenotype:0000047 ! gastrulation variant [Term] id: WBPhenotype:0000363 name: cell division slow def: "Any variation that delays the physical partitioning and separation of a cell into daughter cells compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000438 ! retarded heterochronic variations is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0000364 name: gut granule birefringence misplaced def: "The birefringent inclusions typically found in the intestinal cytoplasm accumulate extracellularly in the intestinal lumen." [WB:WBPaper00025094] is_a: WBPhenotype:0000902 ! intestinal cell morphology variant [Term] id: WBPhenotype:0000365 name: embryo osmotic integrity defective early emb def: "Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] synonym: "embryo osmotic integrity abnormal" NARROW [] is_a: WBPhenotype:0000041 ! osmotic integrity variant is_a: WBPhenotype:0001178 ! egg integrity defective early emb [Term] id: WBPhenotype:0000366 name: three fold arrest def: "Cessation of development that normally occurs in C. elegans 520-620min after the first cleavage at 20C, the stage between the 2-fold and fully elongated embryo." [WB:WBPerson101] synonym: "active elongation arrest" RELATED [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000779 ! late embryonic arrest [Term] id: WBPhenotype:0000367 name: comma arrest emb def: "Cessation of development during the middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "end of epiboly arrest" RELATED [] is_a: WBPhenotype:0000864 ! early elongation arrest [Term] id: WBPhenotype:0000368 name: one point five fold arrest emb def: "Cessation of development that normally occurs in C. elegans 420-460 min after the first embryonic cleavage at 20C, the stage between the comma and 2-fold embryo." [WB:WBPerson101] synonym: "arrest beginning elongation" RELATED [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000864 ! early elongation arrest [Term] id: WBPhenotype:0000369 name: pretzel arrest def: "Cessation of development during the final two stages in embryogenesis, 'early pretzel' stage and 'late pretzel' stage, just prior to hatching. The animal now is folded into four lengths within the eggshell and resembles a pretzel. By early pretzel stage, the head begins to move independently from the body (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "end of elongation arrest" RELATED [] is_a: WBPhenotype:0000779 ! late embryonic arrest [Term] id: WBPhenotype:0000370 name: egg long def: "The fertilized oocytes have a greater than standard length measured end to end compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000037 ! egg morphology variant [Term] id: WBPhenotype:0000371 name: cell division incomplete def: "The physical partitioning and separation of a cell into daughter cells is interupted." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0000372 name: no polar body formation def: "Animals lack the two small cells produced, each during one of the two meiotic cell divisions (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000775 ! meiosis variant [Term] id: WBPhenotype:0000373 name: egg shape variable def: "The overall structure or appearance of fertilized oocytes that are laid exhibit nonconsistent and significant deviation from that of control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000037 ! egg morphology variant [Term] id: WBPhenotype:0000374 name: early divisions prolonged def: "The time interval in which early embryonic cell divisions occur is increased compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000375 name: later divisions prolonged def: "The time interval in which late embryonic cell divisions occur is increased compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000376 name: no uterine cavity def: "Animals lack the inner space of the uterus through which the fertilized egg passes on its way out of the nematode via the vulva (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000289 ! uterus morphology variant [Term] id: WBPhenotype:0000377 name: canal lumen morphology variant def: "Animals exhibit variations in the form, structure or composition of the internal space of the excretory canal compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "canal lumen morphology abnormal" NARROW [] is_a: WBPhenotype:0000704 ! excretory canal morphology variant [Term] id: WBPhenotype:0000378 name: pharyngeal pumping shallow def: "Pharyngeal muscle contractions show less displacement than that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000634 ! pharyngeal pumping variant [Term] id: WBPhenotype:0000379 name: head notched def: "The most anterior portion of the animal contains a V-shaped indentation." [WB:WBPaper00000031] is_a: WBPhenotype:0000071 ! head morphology variant [Term] id: WBPhenotype:0000380 name: expulsion infrequent def: "The final step of the defecation motor program does not occur at each cycle, but is activated occasionally. During this step in C. eslegans specialized enteric muscles contract to expel the contents of the gut through the anus." [WB:WBPaper00002315, WB:WBPerson712] is_a: WBPhenotype:0000996 ! expulsion defective [Term] id: WBPhenotype:0000381 name: serotonin reuptake inhibitor resistant def: "Animals fail to respond to the concentration of serotonin reuptake inhibitors that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0000382 name: serotonin reuptake inhibitor hypersensitive def: "Animals respond to serotonin reuptake inhibitors at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0000383 name: lipid synthesis defective def: "The de novo synthesis of any lipid species is reduced compared to that observed in control animals." [WB:WBPerson712] synonym: "lipid synthesis decreased" RELATED [] is_a: WBPhenotype:0000725 ! lipid metabolism variant [Term] id: WBPhenotype:0000384 name: axon guidance variant def: "Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues)." [GO:0048846, WB:WBPerson2021] synonym: "axon guidance abnormal" NARROW [] synonym: "axon pathfinding abnormal" RELATED [] is_a: WBPhenotype:0001224 ! axon outgrowth variant [Term] id: WBPhenotype:0000385 name: sperm excess def: "Animals produce an increased sperm population compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis variant [Term] id: WBPhenotype:0000386 name: genotoxic induced apoptosis variant def: "Programmed cell death of germ cells caused by exposure to DNA-damaging chemical agents does not occur to the same extent as it does in control animals." [WB:WBPaper00032006, WB:WBPaper00032243, WB:WBPaper00032356, WB:WBPerson712] synonym: "DNA damage induced apoptosis abnormal" RELATED [] synonym: "genotoxic induced apoptosis abnormal" NARROW [] is_a: WBPhenotype:0002152 ! mutagen induced apoptosis variant [Term] id: WBPhenotype:0000387 name: sperm nonmotile def: "The mature male gametes lack self-propelled movement." [GO:0030317, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000987 ! germ cell physiology variant [Term] id: WBPhenotype:0000388 name: sperm morphology variant def: "Any variation in the form, structure or composition of the mature male gamete, which merges with an oocyte to create a fertilized embryo copared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "sperm morphology abnormal" NARROW [] is_a: WBPhenotype:0000900 ! germ cell morphology variant [Term] id: WBPhenotype:0000389 name: hermaphrodite sperm fertilization defective def: "Any perturbation that renders hermaphrodite derived sperm incompetent at fertilizing an oocyte." [WB:WBPaper00001075, WB:WBPerson2021] synonym: "Fer" BROAD [] is_a: WBPhenotype:0000694 ! hermaphrodite sterile [Term] id: WBPhenotype:0000390 name: spermatid activation defective def: "Spermatids fail to mature into active sperm. In C. elegans round sessile spermatids mature into spermatozoa (polarized cells with a motile pseudopod), upon copulation or treatment with proteases." [WB:WBPaper00000884, WB:WBPaper00027300, WB:WBPerson2021] synonym: "spermiogenesis defective " RELATED [] is_a: WBPhenotype:0000670 ! spermatogenesis variant [Term] id: WBPhenotype:0000391 name: defecation missing motor steps def: "Animals lack one or more of the stereotyped muscle contractions that result in defecation compared to control. In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000650 ! defecation variant [Term] id: WBPhenotype:0000392 name: intestinal fluorescence increased def: "Animals exhibit an increase in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine." [WB:WBPerson557] is_a: WBPhenotype:0000293 ! alimentary system pigmentation variant [Term] id: WBPhenotype:0000393 name: cell migration failure def: "Characteristic movement of cells from one site to another is abolished compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000594 ! cell migration variant [Term] id: WBPhenotype:0000394 name: electrophoretic variant protein def: "Any variation in the movement of a protein through a gel matrix when an electric field is applied compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000112 ! protein expression variant [Term] id: WBPhenotype:0000395 name: no differentiated gametes def: "Animals are agametic (lack mature germ cells)." [WB:WBPerson2021] is_a: WBPhenotype:0000894 ! germ cell differentiation variant [Term] id: WBPhenotype:0000396 name: non reflexed gonad arms def: "Gonadal arms do not bend or curve. In C. elegans gonad arms normally reflex to form a stereotypical U-shaped pattern." [WB:WBPaper00005086, WB:WBPaper00029151, WB:WBPerson2021] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0000397 name: harsh body touch resistant def: "Animals do not respond to prodding with a fine platinum wire or similar tool compared to controls." [WB:WBPaper00000502] synonym: "harsh body touch insensitive" RELATED [] is_a: WBPhenotype:0000456 ! touch resistant [Term] id: WBPhenotype:0000398 name: light body touch resistant def: "Animals do not respond to stroking to the head or tail with a hair or similar fiber, but does respond to stronger mechanical stimuli such as prodding with a fine platinum wire or similar tool compared to controls." [WB:WBPaper00000502] synonym: "light body touch insensitive" RELATED [] is_a: WBPhenotype:0000456 ! touch resistant [Term] id: WBPhenotype:0000399 name: somatic gonad development variant def: "Any variation in the progression of the components of the gonad that are separate from the germline proper over time from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "somatic gonad development abnormal" NARROW [] is_a: WBPhenotype:0000691 ! gonad development variant [Term] id: WBPhenotype:0000400 name: somatic gonad primordium development defective def: "The developmental progression of the set of precursor cells that later give rise to the somatic tissues of the gonadal tract is impaired (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0000401 name: no uterus def: "Animals lack the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000624 ! reproductive system development variant [Term] id: WBPhenotype:0000402 name: avoids bacterial lawn def: "Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal." [WB:WBPaper00029071, WB:WBPerson2021] is_a: WBPhenotype:0000659 ! feeding behavior variant [Term] id: WBPhenotype:0000403 name: sperm transfer initiation defective def: "Any defect in the movement of sperm out of the seminal vesicle and into the vas deferens following tonic insertion of spicules into the mating partner compared to control." [WB:WBPaper00028400] is_a: WBPhenotype:0000284 ! sperm transfer defective [Term] id: WBPhenotype:0000404 name: delayed hatching def: "The emergence of larvae from their protective egg shells is retarded compared to control animals." [GO:0035188, WB:WBPerson2021] is_a: WBPhenotype:0000048 ! hatching variant is_a: WBPhenotype:0000438 ! retarded heterochronic variations [Term] id: WBPhenotype:0000405 name: giant oocytes def: "The size of haploid female germ cells (oocytes) are significantly larger compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "oocytes large" RELATED [] is_a: WBPhenotype:0001260 ! oocyte morphology variant [Term] id: WBPhenotype:0000406 name: lumpy def: "Animals have protrusions or bumps on their exterior which are not characteristic of control animals." [WB:WBPerson557] is_a: WBPhenotype:0000535 ! organism morphology variant [Term] id: WBPhenotype:0000408 name: dauer recovery inhibited def: "The process through which a dauer larva reverts to normal developmental programs is blocked." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000127 ! dauer recovery variant [Term] id: WBPhenotype:0000409 name: organism morphology variable def: "Animals exhibit variations in the form, structure or composition of any of its parts at different stages of the lifecycle, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "Vab" BROAD [] is_a: WBPhenotype:0000535 ! organism morphology variant [Term] id: WBPhenotype:0000410 name: no defecation cycle def: "Animals lack the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000207 ! defecation cycle variant [Term] id: WBPhenotype:0000411 name: rod like larval lethal def: "Animals die as rigid, rod-like larva. In C. elegans this defect is often caused by the misspecification of the excretory duct cell." [WB:WBPaper00001366, WB:WBPaper00002764, WB:WBPerson2021] synonym: "Let" RELATED [] synonym: "Lvl" BROAD [] is_a: WBPhenotype:0000035 ! larval body morphology variant is_a: WBPhenotype:0000054 ! larval lethal [Term] id: WBPhenotype:0000412 name: octanol chemotaxis defective def: "Failure to execute the characteristic response to 1-octanol as defined by control animals. In C.elegans 1-octanol is typically a repellant." [WB:WBPaper00002314] is_a: WBPhenotype:0001448 ! odorant negative chemotaxis defective is_a: WBPhenotype:0001452 ! octanol chemotaxis variant [Term] id: WBPhenotype:0000413 name: pharyngeal muscle paralyzed def: "Pharyngeal muscle is immobilized resulting in lack of pumping or lack of response to external stimulation." [WB:cab, WB:WBPerson557] is_a: WBPhenotype:0000980 ! pharyngeal contraction variant [Term] id: WBPhenotype:0000414 name: cell fate transformation def: "The cell takes on a different identity from which it was initially committed." [GO:0045165, WB:WBPaper00002924, WB:WBPerson712] is_a: WBPhenotype:0000216 ! cell fate specification variant [Term] id: WBPhenotype:0000415 name: necrotic cell death variant def: "Animals exhibit variations in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control." [GO:0070265, WB:WBPerson712] synonym: "necrotic cell death abnormal" NARROW [] is_a: WBPhenotype:0001173 ! non apoptotic cell death variant [Term] id: WBPhenotype:0000416 name: yolk synthesis variant def: "Variations in the generation of the nutrient protein produced by intestinal cells and secreted by them into the pseudocoelom, from which it can be shared with other tissues in the body compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "vitellogenin synthesis abnormal" RELATED [] synonym: "yolk synthesis abnormal" NARROW [] is_a: WBPhenotype:0001093 ! intestinal physiology variant [Term] id: WBPhenotype:0000417 name: cell division failure def: "The process of physical partitioning and separation of a cell into daughter cells is abolished." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0000418 name: intestinal cell division failure def: "The physical partitioning and separation of an intestinal cell into daughter cells is abolished." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000417 ! cell division failure [Term] id: WBPhenotype:0000419 name: L3 lethal def: "Animals die at the L3 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD [] is_a: WBPhenotype:0000058 ! late larval lethal is_a: WBPhenotype:0000116 ! mid larval lethal [Term] id: WBPhenotype:0000420 name: levamisole hypersensitive def: " Animals respond to levamisole at a lower concentration or a shorter exposure compared to control animals. Levamisole is a cholinergic agonist." [WB:WBPerson557] synonym: "tetramisole hypersensitive" RELATED [] is_a: WBPhenotype:0000845 ! levamisole response variant is_a: WBPhenotype:0001579 ! cholinergic agonist hypersensitive [Term] id: WBPhenotype:0000421 name: levamisole resistant def: "Animals fail to respond to the concentration of levamisole that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans resistance to levamisole is often assayed via body contraction response, ventral tail curling response etc." [WB:WBPaper00000484, WB:WBPerson2021] synonym: "Lev R" BROAD [] synonym: "tetramisole resistant" RELATED [] is_a: WBPhenotype:0000845 ! levamisole response variant is_a: WBPhenotype:0001578 ! cholinergic agonist resistant [Term] id: WBPhenotype:0000422 name: twitcher def: "Animals exhibit spasmodic muscle twitching superimposed on normal sinusoidal motion." [WB:WBPaper00000484] is_a: WBPhenotype:0001701 ! spastic locomotion [Term] id: WBPhenotype:0000423 name: head muscle contraction variant def: "Any variation in the contractions of the muscles in the most anterior body region of the animal compared to control." [WB:WBPerson557] synonym: "head muscle contraction abnormal" NARROW [] is_a: WBPhenotype:0000611 ! muscle system physiology variant [Term] id: WBPhenotype:0000424 name: antibody staining variant def: "Any variation in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "antibody staining abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein expression variant [Term] id: WBPhenotype:0000425 name: antibody staining reduced def: "Any variation that results in a decrease in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000424 ! antibody staining variant [Term] id: WBPhenotype:0000426 name: antibody staining increased def: "Any variation that results in an increase in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000424 ! antibody staining variant [Term] id: WBPhenotype:0000427 name: no cuticle def: "Animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000201 ! cuticle development variant [Term] id: WBPhenotype:0000428 name: no adult cuticle def: "Adult animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000427 ! no cuticle [Term] id: WBPhenotype:0000429 name: copulatory structure development variant def: "Any variation in the progression of the specialized structures of the animal which allow the successful transfer of sperm from one organism to another, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "copulatory structure development abnormal" NARROW [] is_a: WBPhenotype:0000624 ! reproductive system development variant [Term] id: WBPhenotype:0000430 name: male copulatory structure development variant def: "Any variation in the progression of the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm over time from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "male copulatory structure development abnormal" NARROW [] is_a: WBPhenotype:0000429 ! copulatory structure development variant [Term] id: WBPhenotype:0000431 name: hermaphrodite copulatory structure development variant def: "Any variation in the progression of the specialized structures of a hermaphrodite which allow the successful transfer of sperm from a male, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite copulatory structure development abnormal" NARROW [] is_a: WBPhenotype:0000429 ! copulatory structure development variant [Term] id: WBPhenotype:0000432 name: male copulatory structure absent def: "Animals lack the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000430 ! male copulatory structure development variant [Term] id: WBPhenotype:0000433 name: DNA synthesis variant def: "Variations in the processes involving the production of new DNA strands compared to control." [GO:0006260, WB:WBPerson2021] synonym: "DNA synthesis abnormal" NARROW [] is_a: WBPhenotype:0000732 ! DNA metabolism variant [Term] id: WBPhenotype:0000434 name: sexual maturation defective def: "The developmental process by which a progressive change in the state of some part of an organism specifically contributing to its ability to form offspring is impaired." [GO:0003006, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000624 ! reproductive system development variant [Term] id: WBPhenotype:0000436 name: protein subcellular localization variant def: "Any variation in the placement of a protein within in a cell or cellular compartment compared to control." [WB:WBPerson557] synonym: "protein localization abnormal" EXACT [] synonym: "protein subcellular localization abnormal" NARROW [] is_a: WBPhenotype:0001408 ! pattern protein expression variant [Term] id: WBPhenotype:0000438 name: retarded heterochronic variations def: "Variations that result in the deceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control." [GO:0040034, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000033 ! developmental timing variant [Term] id: WBPhenotype:0000439 name: precocious heterochronic variations def: "Variations that result in the acceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control." [GO:0040034, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000033 ! developmental timing variant [Term] id: WBPhenotype:0000440 name: excretory canals long def: "The structure made by the processes of the excretory canal cell is increased in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "long excretory canals" RELATED [] is_a: WBPhenotype:0000704 ! excretory canal morphology variant [Term] id: WBPhenotype:0000441 name: tail rounded def: "Tails change shape and undergo retraction thereby forming a 'peloderan' or 'rounded' adult tail." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000073 ! tail morphology variant [Term] id: WBPhenotype:0000442 name: larval development retarded def: "The developmental progression of a larva over time, from its formation to its mature structure is delayed compared to control. The larva is the early, immature form of an animal between hatching and adulthood." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000438 ! retarded heterochronic variations is_a: WBPhenotype:0000750 ! larval development variant [Term] id: WBPhenotype:0000443 name: spicule morphology variant def: "Any variation in the appearance of the elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "spicule morphology abnormal" NARROW [] is_a: WBPhenotype:0001024 ! male morphology variant [Term] id: WBPhenotype:0000444 name: bursa elongated def: "The length of the adult male tail, including the lateral fan and rays, is extended compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000342 ! bursa morphology variant [Term] id: WBPhenotype:0000445 name: yolk synthesis in males def: "Males generate yolk, the nutrient protein, normally produced and secreted by hermaphrodite or female intestinal cells." [WB:WBPerson2021, WB:WBPerson557] synonym: "vitellogenin synthesis in males" RELATED [] is_a: WBPhenotype:0000416 ! yolk synthesis variant [Term] id: WBPhenotype:0000446 name: supernumerary molt def: "Animals execute extra larval molts compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0002041 ! molt variant [Term] id: WBPhenotype:0000447 name: adult development variant def: "Variations in the progression of an animal over time from the end of larval stage to a mature adult compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "adult development abnormal" NARROW [] is_a: WBPhenotype:0000049 ! postembryonic development variant [Term] id: WBPhenotype:0000448 name: adult cuticle development variant def: "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time in adults compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "adult cuticle development abnormal" NARROW [] is_a: WBPhenotype:0000447 ! adult development variant [Term] id: WBPhenotype:0000449 name: second adult cuticle def: "A duplication of the developmental program that forms the adult-type rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells." [WB:WBPaper00001439] is_a: WBPhenotype:0000448 ! adult cuticle development variant [Term] id: WBPhenotype:0000451 name: head protrusion def: "Any irregular swelling in discrete regions of the head." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000071 ! head morphology variant [Term] id: WBPhenotype:0000452 name: tail protrusions def: "Any irregular swelling in discrete regions of the tail, usually caused by a local defect in the normal smooth tapering of the hypodermis and/or cuticle (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000073 ! tail morphology variant [Term] id: WBPhenotype:0000453 name: body protrusions def: "Any irregular swelling in discrete regions of the body region between the head and the tail." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000072 ! body morphology variant [Term] id: WBPhenotype:0000454 name: head twisted def: "The anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring)of the body appears distorted, usually due to uncharacteristic winding." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000071 ! head morphology variant [Term] id: WBPhenotype:0000455 name: jerky movement def: "Animals exhibit abrupt transitions while traveling from one location to another." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001701 ! spastic locomotion [Term] id: WBPhenotype:0000456 name: touch resistant def: "Variations in characteristic response with respect to perception or transmission of a touch stimulus compared to responses in control animals." [WB:WBPerson557] synonym: "touch insensitive" RELATED [] is_a: WBPhenotype:0000315 ! mechanosensation variant [Term] id: WBPhenotype:0000457 name: organism starvation hypersensitive def: "Animals show enhanced suceptibility to deprivation of nourishment, compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000147 ! organism starvation response variant [Term] id: WBPhenotype:0000458 name: starvation resistant def: "Animals show enhanced tolerance to deprivation of nourishment, compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000147 ! organism starvation response variant [Term] id: WBPhenotype:0000459 name: pesticide response variant def: "Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals." [WB:WBPerson557] synonym: "pesticide response abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0000460 name: paraquat response variant def: "Animals exhibit variations in their response to paraquat compared to that observed in control animals." [WB:WBPerson557] synonym: "methyl viologen response abnormal" RELATED [] synonym: "paraquat response abnormal" NARROW [] is_a: WBPhenotype:0000068 ! oxidative stress response variant is_a: WBPhenotype:0000459 ! pesticide response variant is_a: WBPhenotype:0001620 ! organism oxidative stress response variant [Term] id: WBPhenotype:0000461 name: paraquat resistant def: "Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000460 ! paraquat response variant [Term] id: WBPhenotype:0000462 name: paraquat hypersensitive def: "Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] synonym: "reactive oxygen species hypersensitive" BROAD [WB:WBPaper00031296] is_a: WBPhenotype:0000460 ! paraquat response variant [Term] id: WBPhenotype:0000463 name: metabolic pathway variant def: "Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GO:0008152, WB:WBPerson712] synonym: "metabolic pathway abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0000464 name: oxygen response variant def: "Animals exhibit variations in their response to oxygen compared to that observed in control animals." [WB:WBPerson557] synonym: "oxygen response abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0000465 name: high oxygen resistant def: "Animals fail to respond to the high concentrations of oxygen that elicit a response in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000464 ! oxygen response variant [Term] id: WBPhenotype:0000466 name: high oxygen hypersensitive def: "Animals respond to hyperoxic (high oxygen tension) conditions after a shorter exposure time compared to control." [GO:0055093, WB:WBPerson2021] is_a: WBPhenotype:0000464 ! oxygen response variant [Term] id: WBPhenotype:0000467 name: age associated fluorescence increased def: "Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control." [WB:WBPaper00033040, WB:WBPerson2021] is_a: WBPhenotype:0001009 ! developmental pigmentation variant [Term] id: WBPhenotype:0000468 name: age associated fluorescence reduced def: "Animals exhibit a decrease in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0001009 ! developmental pigmentation variant [Term] id: WBPhenotype:0000469 name: Q neuroblast lineage migration variant def: "The daughters of the Q neuroblasts exhibit variation in their characteristic movements compared to control animals." [WB:WBPaper00001954, WB:WBPaper00031356, WB:WBPerson712] synonym: "Q neuroblast lineage migration abnormal" NARROW [] is_a: WBPhenotype:0001140 ! neuron migration variant [Term] id: WBPhenotype:0000470 name: HSN migration variant def: "Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo compared to control animals." [WB:WBPaper00001836, WB:WBPerson2021] synonym: "HSN migration abnormal" NARROW [] is_a: WBPhenotype:0001229 ! anterior neuron migration defective [Term] id: WBPhenotype:0000471 name: ALM migration variant def: "Any variation in the normal posterior movement of the ALM mechanosensory neurons from their birthplace (anterior to the V1 hypodermal cell) to positions in between the V2 and V3 cells in the embryo compared to control animals." [WB:WBPaper00001304, WB:WBPaper00003058, WB:WBPerson2021] synonym: "ALM migration abnormal" NARROW [] is_a: WBPhenotype:0001520 ! posterior neuron migration variant [Term] id: WBPhenotype:0000472 name: endoderm absent def: "Animals lack the early blast cells that give rise to the gut tissue (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000473 name: progressive paralysis def: "Animals become increasingly sluggish/immobilized as they age." [WB:WBPaper00001709] is_a: WBPhenotype:0000644 ! paralyzed [Term] id: WBPhenotype:0000474 name: muscle attachment variant def: "Any variation in the connection of the cell(s) whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "Mua" BROAD [] synonym: "muscle attachment abnormal" NARROW [] is_a: WBPhenotype:0000622 ! muscle system development variant [Term] id: WBPhenotype:0000475 name: muscle detached def: "Animals fail to establish or maintain the connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000474 ! muscle attachment variant [Term] id: WBPhenotype:0000476 name: progressive muscle detachment def: "The connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues diminishes over time." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000474 ! muscle attachment variant [Term] id: WBPhenotype:0000477 name: nucleolus refraction variant def: "Any variation in the change in direction of a wave of light after passage through the nucleolus compared to control. The nucleolus is a small dense body in the nucleus." [WB:WBPerson2021, WB:WBPerson557] synonym: "nucleolus refraction abnormal" NARROW [] is_a: WBPhenotype:0000722 ! nucleolus variant [Term] id: WBPhenotype:0000478 name: isothermal tracking behavior variant def: "Variations in the ability of an animal to remain within a defined temperature. In C. elegans, animals tend to track and stay within a temperature that is most closely related to their cultivation temperature." [WB:WBPaper00002214] subset: phenotype_slim_wb synonym: "isothermal tracking behavior abnormal" NARROW [] synonym: "thermotaxis abnormal" RELATED [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000479 name: egg pale def: "Eggs show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000970 ! embryonic pigmentation variant is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000480 name: pyrazine chemotaxis defective def: "Failure to execute the characteristic response to pyrazine as defined by control animals. In C. elegans pyrazine is typically an attractant." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective is_a: WBPhenotype:0001474 ! pyrazine chemotaxis variant [Term] id: WBPhenotype:0000481 name: negative chemotaxis variant def: "Any variation in the directed movement of an animal in response to chemical repellants as defined by control animals." [GO:0050919, WB:cab] synonym: "chemical avoidance abnormal" RELATED [] synonym: "chemoaversion abnormal" RELATED [] synonym: "negative chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001434 ! chemotaxis variant [Term] id: WBPhenotype:0000482 name: garlic chemotaxis defective def: "Failure to execute the characteristic response to garlic as defined by control animals. In C. elegans, garlic is typically a repellent." [WB:WBPaper00001374] is_a: WBPhenotype:0001449 ! aqueous negative chemotaxis defective is_a: WBPhenotype:0001451 ! garlic chemotaxis variant [Term] id: WBPhenotype:0000483 name: no gut granules def: "Animals lack the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000103 ! gut granule development variant [Term] id: WBPhenotype:0000484 name: embryo small def: "The organism's size during the embryonic developmental stage is decreased compared to that observed in control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001136 ! embryonic morphology variant [Term] id: WBPhenotype:0000485 name: dauer death increased def: "The survival of animals in the alternative larval stage which they enter when placed under conditions of environmental stress is reduced." [WB:WBPerson2021, WB:WBPerson557] synonym: "reduced dauer survival" RELATED [] is_a: WBPhenotype:0000159 ! dauer arrest variant [Term] id: WBPhenotype:0000486 name: colchicine hypersensitive def: "Animals respond to colchicine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0000487 name: colchicine resistant def: "Animals fail to respond to the concentration of colchicine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0000488 name: chloroquinone hypersensitive def: "Animals respond to chloroquinone at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0000489 name: chloroquinone resistant def: "Animals fail to respond to the concentration of chloroquinone that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0000490 name: pharynx disorganized def: "The components of the feeding organ fail to be arranged in the same manner as control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000707 ! pharyngeal development variant [Term] id: WBPhenotype:0000491 name: isthmus morphology defective def: "Any observed morphological defects of the isthmus." [WB:WBPerson2021] synonym: "isthmus malformed" RELATED [] synonym: "isthmus morphology abnormal" NARROW [] is_a: WBPhenotype:0000709 ! pharyngeal morphology variant [Term] id: WBPhenotype:0000492 name: corpus morphology defective def: "Any variation in the form, structure or composition of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb compared to control (Wormatlas)." [WB:WBPerson2021] synonym: "corpus malformed" RELATED [] synonym: "corpus morphology abnormal" NARROW [] is_a: WBPhenotype:0000709 ! pharyngeal morphology variant [Term] id: WBPhenotype:0000493 name: metacorpus morphology defective def: "Any variation in the form, structure or composition of the first pharyngeal bulb compared to control." [WB:WBPerson2021] synonym: "metacarpas malformed" RELATED [] synonym: "metacorpus morphology abnormal" NARROW [] is_a: WBPhenotype:0000709 ! pharyngeal morphology variant [Term] id: WBPhenotype:0000494 name: two fold arrest def: "Cessation of development that normally occurs in C. elegans 460-520 min after the first cleavage at 20C, the stage between the 1.5-fold and 3-fold embryo." [WB:WBPerson101] is_a: WBPhenotype:0000779 ! late embryonic arrest [Term] id: WBPhenotype:0000495 name: ray ectopic def: "Animals have extra finger-like sensory sensilla that project from the tail and embed in the male fan compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000199 ! male tail sensory ray development variant [Term] id: WBPhenotype:0000496 name: male posterid sensilla absent def: "Males lack the specialized sensory papillae that lie along the posterior half of the body." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001008 ! male nervous system development variant [Term] id: WBPhenotype:0000497 name: organism gamma ray response variant def: "Animals exhibit variations in their response to gamma ray radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "organism gamma ray response abnormal" NARROW [] is_a: WBPhenotype:0000686 ! organism ionizing radiation response variant [Term] id: WBPhenotype:0000498 name: methyl methanesulfonate response variant def: "Animals exhibit variations in their response to methyl methanesulfonate compared to that observed in control animals." [WB:WBPerson557] synonym: "methyl methanesulfonate response abnormal" NARROW [] synonym: "MMS response abnormal" RELATED [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000499 name: ethyl methanesulfonate response variant def: "Animals exhibit variations in their response to ethyl methanesulfonate (EMS) compared to that observed in control animals." [WB:WBPerson557] synonym: "EMS response abnormal" RELATED [] synonym: "ethyl methanesulfonate response abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000500 name: acetylcholinesterase inhibitor hypersensitive def: "Animals respond to an acetylcholinesterase inhibitor at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive is_a: WBPhenotype:0001290 ! acetylcholinesterase inhibitor response variant [Term] id: WBPhenotype:0000501 name: left handed roller def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the left-handed direction. In liquid media, wave propogation is helical rather than planar." [WB:WBPerson2021, WB:WBPerson557] synonym: "Rol" RELATED [] is_a: WBPhenotype:0000645 ! roller [Term] id: WBPhenotype:0000502 name: right handed roller def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the right-handed direction. In liquid media, wave propogation is helical rather than planar." [WB:WBPerson2021, WB:WBPerson557] synonym: "Rol" BROAD [] is_a: WBPhenotype:0000645 ! roller [Term] id: WBPhenotype:0000503 name: endoreduplication variant def: "Any variation in the multiple rounds of DNA replication that take place without chromosome condensation, segregation or cytokinesis compared to control. In C. elegans this process is normally seen in intestinal nuclei during each larval lethargus which results in adult intestinal nuclei with 32 copies (32C) of each chromosome(Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "endoreduplication abnormal" NARROW [] is_a: WBPhenotype:0000732 ! DNA metabolism variant [Term] id: WBPhenotype:0000504 name: nuclear division variant def: "Any variation in the process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei, compared to control." [WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. subset: phenotype_slim_wb synonym: "karyokinesis abnormal" RELATED [] synonym: "nuclear division abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000505 name: male ray morphology variant def: "Animals exhibit variations in the structure or organization of any of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control animals. In C. elegans, nine bilateral rays project from the tail in a radial pattern with a smooth and slightly tapered appearance. Although one neuronal member of each ray sensillum is exposed to the outside, male rays rarely take up dye." [WB:WBPaper00000932, WB:WBPaper00001328, WB:WBPaper00002149, WB:WBPaper00029016, WB:WBPerson712] synonym: "male ray morphology abnormal" NARROW [] synonym: "Ram" BROAD [] is_a: WBPhenotype:0000299 ! sensillum morphology variant is_a: WBPhenotype:0001358 ! male nervous system morphology variant [Term] id: WBPhenotype:0000506 name: bursa swollen def: "The adult male tail, including the lateral fan and rays, appears bloated or distended." [WB:WBPerson2021, WB:WBPerson557] synonym: "swollen male tail" EXACT [] is_a: WBPhenotype:0000342 ! bursa morphology variant [Term] id: WBPhenotype:0000507 name: acetylcholine levels variant def: "Animals exhibit variations in the amount of acetylcholine compared to control animals at a defined stage. Acetylcholine is the acetic acid ester of the organic base choline." [WB:WBPerson2021, WB:WBPerson557] synonym: "acetylcholine levels abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0000508 name: nonsense mRNA accumulation def: "Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail." [GO:0070478, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0000509 name: sperm pseudopod variant def: "Variation in the morphological appearance or composition of the pseudopod, a cellular projection that facilitates motility of the spermatozoa." [WB:WBPaper00001075, WB:WBPerson2021] synonym: "sperm pseudopod abnormal" NARROW [] is_a: WBPhenotype:0000388 ! sperm morphology variant [Term] id: WBPhenotype:0000510 name: vulval invagination variant L4 def: "The characteristic Christmas-tree shaped invagination formed by the terminal vulval cells at the mid-late L4 stage is altered." [WB:WBPaper00001738, WB:WBPerson2021] synonym: "vulval invagination abnormal" NARROW [] synonym: "vulval invagination L4 abnormal" NARROW [] synonym: "vulval invagination L4 variant" RELATED [] is_a: WBPhenotype:0000695 ! vulva morphology variant is_a: WBPhenotype:0000699 ! vulva development variant [Term] id: WBPhenotype:0000511 name: nuclear positioning variant def: "Variations in the directed movement of the nucleus to a specific location within a cell compared to control." [GO:0040023, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. subset: phenotype_slim_wb synonym: "nuclear migration variant" RELATED [] synonym: "nuclear positioning abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant [Term] id: WBPhenotype:0000512 name: VNC nuclear positioning variant def: "Variations in spacing or location were observed between adjacent ventral cord nuclei or between ventral cord nuclei and another nucleus used as a reference point. In C. elegans, these nuclei are distributed equally and predictably, such that they can be unambiguously distinguished by their position." [WB:WBPaper00031891, WB:WBPerson712] synonym: "VNC nuclear migration variant" RELATED [] synonym: "VNC nuclear positioning abnormal" NARROW [] is_a: WBPhenotype:0000511 ! nuclear positioning variant [Term] id: WBPhenotype:0000514 name: rubber band def: "When prodded on the head, worm contracts and then relaxes along its entire body without moving backwards, compared to a control worm which contracts its anterior end and backs away in response to prodding." [WB:WBPaper00006135, WB:WBPerson2021] synonym: "Rbr" BROAD [] synonym: "rubberband" EXACT [] is_a: WBPhenotype:0000315 ! mechanosensation variant [Term] id: WBPhenotype:0000515 name: ventral nerve cord development variant def: "Variations in any process whose specific outcome is the development and/or maintenance of the ventral nerve cord." [WB:WBPerson557] synonym: "ventral nerve cord development abnormal" NARROW [] is_a: WBPhenotype:0000945 ! neuropil development variant [Term] id: WBPhenotype:0000516 name: ventral cord disorganized def: "The longitudinal nerve cord of the midbody region, connecting the nerve ring and tail ganglia, is not arranged in the same manner as control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000976 ! ventral cord patterning variant [Term] id: WBPhenotype:0000517 name: behavior variant def: "Variations in the specific actions or reactions in response to external or internal stimuli compared to that observed in control animals." [GO:0007610, WB:WBPerson557] synonym: "behavior abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000518 name: development variant def: "Variations in the progression of an integrated living unit (a cell, tissue, organ or organism) over time from an initial condition to a later condition compared to control animals." [GO:0032502, WB:WBPerson2021] synonym: "development abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000519 name: physiology variant def: "Animals exhibit variations in any physical or chemical process required for the cell, tissue, organ system or organism to carry out its normal functions and activities or be able to perceive and respond to stimuli compared to control animals." [WB:WBPerson712] synonym: "physiology abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000520 name: morphology variant def: "Animals exhibit variations in the form, structure or composition of any of its parts compared to control animals." [WB:WBPerson712] synonym: "morphology abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000521 name: pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency." [WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000522 name: organism region behavior variant def: "Variations in the specific actions or reactions of a certain defined body area of an animal in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism region behavior abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000523 name: chemical response variant def: "Animals exhibit variations in their response to a specific chemical compared to that observed in control animals." [WB:WBPerson557] synonym: "chemical response abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0000524 name: bleach response variant def: "Animals exhibit variations in their response to bleach compared to that observed in control animals." [WB:WBPerson557] synonym: "bleach response abnormal" NARROW [] is_a: WBPhenotype:0001379 ! organism toxic chemical response variant [Term] id: WBPhenotype:0000525 name: organism behavior variant def: "Variations in the specific actions or reactions of an organism in response to external or internal stimuli compared to that observed in control organisms." [GO:0007610, WB:WBPerson557] subset: phenotype_slim_wb synonym: "organism behavior abnormal" NARROW [] is_a: WBPhenotype:0000517 ! behavior variant [Term] id: WBPhenotype:0000526 name: cell pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a cell." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "cell pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000521 ! pigmentation variant [Term] id: WBPhenotype:0000527 name: organism pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "Abnormal Coloration" RELATED [] synonym: "organism pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000521 ! pigmentation variant [Term] id: WBPhenotype:0000528 name: body region development variant def: "Variations in the progression of the overall structure or appearance of a discrete region of an animal's anatomy over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body region development abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism development variant [Term] id: WBPhenotype:0000529 name: cell development variant def: "Any variation in the progression of a cell from when it is first formed to when it becomes a mature structure when compared to control animals." [GO:0048468, WB:cab] subset: phenotype_slim_wb synonym: "cell development abnormal" NARROW [] is_a: WBPhenotype:0000518 ! development variant [Term] id: WBPhenotype:0000530 name: organ system development variant def: "Any variation in the progression of an organismal system from its formation to the mature structure when compared to control animals." [GO:0048731, WB:cab] subset: phenotype_slim_wb synonym: "organ system development abnormal" NARROW [] is_a: WBPhenotype:0000518 ! development variant [Term] id: WBPhenotype:0000531 name: organism development variant def: "Any variation in the progression of a worm at any time from its fertilization to adulthood compared to control." [WB:cab] subset: phenotype_slim_wb synonym: "organism development abnormal" NARROW [] is_a: WBPhenotype:0000518 ! development variant [Term] id: WBPhenotype:0000532 name: body region morphology variant def: "Animals exhibit variations in the form, structure or composition of a discrete region of their anatomy compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body region morphology abnormal" NARROW [] is_a: WBPhenotype:0000535 ! organism morphology variant [Term] id: WBPhenotype:0000533 name: cell morphology variant def: "Any variation in the form or composition of the basic structural and functional unit of all organisms compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GO:0005623, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000520 ! morphology variant [Term] id: WBPhenotype:0000534 name: organ system morphology variant def: "Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that comprise a specific organ system." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "organ system morphology abnormal" NARROW [] is_a: WBPhenotype:0000520 ! morphology variant [Term] id: WBPhenotype:0000535 name: organism morphology variant def: "Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395] subset: phenotype_slim_wb synonym: "Bmd" BROAD [] synonym: "body morphology defects" RELATED [] synonym: "organism morphology abnormal" NARROW [] is_a: WBPhenotype:0000520 ! morphology variant [Term] id: WBPhenotype:0000536 name: cell physiology variant def: "Animals exhibit variations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for the cell to carry out its normal functions or be able to perceive and respond to stimuli, compared to control animals." [GO:0009987] subset: phenotype_slim_wb synonym: "cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000519 ! physiology variant [Term] id: WBPhenotype:0000539 name: dorsal nerve cord development variant def: "Variations in the progression of the anatomical structures that consist of processes of ventral cord motor neurons that send commissures to the dorsal side, as well as processes of certain head and tail neurons, over time from initial formation to mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dorsal nerve cord development abnormal" NARROW [] is_a: WBPhenotype:0000945 ! neuropil development variant [Term] id: WBPhenotype:0000540 name: muscle arm development variant def: "Variations in the progression of the process extension from the muscle belly by which the muscle cells reach to the nerve cords to obtain innervation over time from initial formation to mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712] synonym: "muscle arm development abnormal" NARROW [] synonym: "muscle arm extension variant" RELATED [] is_a: WBPhenotype:0000087 ! body wall cell development variant [Term] id: WBPhenotype:0000541 name: cord commissures fail to reach target def: "Axon tracts fail to complete the connection between nerve cords. In C. elegans, these tracts grow circumferentially around the animal, completing the connection between the ventral and dorsal nerve cords." [WB:WBPaper00001499, WB:WBPaper00028984, WB:WBPerson712] is_a: WBPhenotype:0000014 ! cord commissures variant [Term] id: WBPhenotype:0000542 name: fat def: "Animals exhibit an increased girth compared to a control animal of the same developmental stage." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001727 ! body width variant [Term] id: WBPhenotype:0000543 name: forward kinker def: "Forward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves forward with uncharacteristic muscle spasms causing loss of smooth sinusoidal motion or body posture (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000002 ! kinker [Term] id: WBPhenotype:0000544 name: backward kinker def: "Backward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves backward with uncharacteristic muscle spasms causing loss of smooth sinusoidal motion or body posture (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000002 ! kinker [Term] id: WBPhenotype:0000545 name: egg retention def: "Eggs are retained in the uterus at a later stage when compared with control animals." [WB:cab] synonym: "late eggs laid" RELATED [] is_a: WBPhenotype:0000006 ! egg laying defective [Term] id: WBPhenotype:0000546 name: early eggs laid def: "Eggs are laid at an earlier stage of development when compared with control animals." [WB:cab] is_a: WBPhenotype:0000005 ! hyperactive egg laying is_a: WBPhenotype:0000439 ! precocious heterochronic variations [Term] id: WBPhenotype:0000547 name: starved def: "Animals exhibit morphological characteristics that are the outcome of nutrient deprivation. In C. elegans, starved worms have fewer refractile granules in intestinal cells, making them appear pale. Strongly starved mutants are small and thin, and tend to retain fewer eggs than control animals." [WB:WBPaper00001709, WB:WBPerson2021] synonym: "Eat" RELATED [] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0000548 name: muscle dystrophy def: "Progressive degeneration of muscle." [WB:cab] is_a: WBPhenotype:0000611 ! muscle system physiology variant [Term] id: WBPhenotype:0000549 name: head muscle dystrophy def: "Progressive degeneration of the head muscle." [WB:cab] is_a: WBPhenotype:0000548 ! muscle dystrophy is_a: WBPhenotype:0001002 ! head muscle behavior variant [Term] id: WBPhenotype:0000550 name: body muscle dystrophy def: "Progressive degeneration of muscle along the body wall." [WB:cab] synonym: "body wall muscle dystrophy" RELATED [] is_a: WBPhenotype:0000548 ! muscle dystrophy is_a: WBPhenotype:0000596 ! body behavior variant [Term] id: WBPhenotype:0000551 name: omega turns variant def: "Animals exhibit variations in the rate of sharp head to tail turns compared to control animals." [WB:WBPaper00000075, WB:WBPaper00006375, WB:WBPerson712] synonym: "omega turns abnormal" NARROW [] is_a: WBPhenotype:0001702 ! directionality variant [Term] id: WBPhenotype:0000552 name: GABA levels variant def: "Animals exhibit variations in the amount of GABA compared to control animals at a defined stage." [WB:WBPerson2021, WB:WBPerson557] synonym: "GABA levels abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0000553 name: muscle birefringence variant def: "Animals exhibit a weak and abnormal birefringency pattern in muscle fibers when examined using polarized optics." [WB:WBPerson557] comment: Disorganized muscle fibers display a weak and abnormal birefringency pattern when examined using polarized optics. synonym: "Dim" EXACT [] synonym: "disorganized muscle" EXACT [] synonym: "muscle birefringence abnormal" RELATED [] is_a: WBPhenotype:0000926 ! body wall muscle morphology variant [Term] id: WBPhenotype:0000554 name: hypoosmotic shock hypersensitive def: "Any variation in the ability to adjust to a decline in ambient solute concentrations, thereby causing the body to swell and explode." [WB:WBPaper00000484, WB:WBPerson2021] is_a: WBPhenotype:0000041 ! osmotic integrity variant [Term] id: WBPhenotype:0000555 name: drug adaptation variant def: "Animals show variations in their decreased responsiveness after prolonged or repeated exposure to a drug compared to that in control." [WB:WBPerson2021, WB:WBPerson557] synonym: "drug adaptation abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0000556 name: dopamine adaptation variant def: "Animals show variations in their decreased responsiveness after prolonged or repeated exposure to dopamine compared to that in control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dopamine adaptation abnormal" NARROW [] is_a: WBPhenotype:0000555 ! drug adaptation variant [Term] id: WBPhenotype:0000557 name: dopamine adaptation defective def: "Animals do not exhibit decreased responsiveness after prolonged or repeated exposure to dopamine." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000556 ! dopamine adaptation variant [Term] id: WBPhenotype:0000558 name: calcium channel modulator response variant def: "Animals exhibit variations in their response to specific calcium channel modulators compared to that observed in control animals." [WB:WBPerson557] synonym: "calcium channel modulator response abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant is_a: WBPhenotype:0001833 ! membrane trafficking variant [Term] id: WBPhenotype:0000559 name: calcium channel modulator hypersensitive def: "Animals respond to a calcium channel modulator at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive is_a: WBPhenotype:0000558 ! calcium channel modulator response variant [Term] id: WBPhenotype:0000560 name: calcium channel modulator resistant def: "Animals fail to respond to the concentration of calcium channel modulators that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant is_a: WBPhenotype:0000558 ! calcium channel modulator response variant [Term] id: WBPhenotype:0000561 name: head levamisole resistant def: "The heads of animals fail to respond to the concentration of levamisole that elicits a response in control animals. In C. elegans, heads contract at >10uM for intact animals and >1uM for cut animals." [WB:WBPaper00000484] synonym: "head tetramisole resistant" RELATED [] is_a: WBPhenotype:0000421 ! levamisole resistant [Term] id: WBPhenotype:0000562 name: body levamisole resistant def: "The bodies of animals fail to respond to the concentration of levamisole that elicits a response in control animals." [WB:WBPaper00000484] synonym: "body tetramisole resistant" RELATED [] is_a: WBPhenotype:0000421 ! levamisole resistant [Term] id: WBPhenotype:0000563 name: shrinker def: "The whole body undergoes longitudinal shortening in response to head touch or tail touch (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001701 ! spastic locomotion [Term] id: WBPhenotype:0000564 name: echo defecation cycle def: "Muscle contractions that make up the defecation motor program are repeated before the onset of the next cycle unlike in control animals." [WB:WBPaper00002305, WB:WBPaper00003765, WB:WBPerson712] is_a: WBPhenotype:0000207 ! defecation cycle variant [Term] id: WBPhenotype:0000565 name: coiler def: "The body of an animal assumes a coil-like shape when it attempts to move." [WB:WBPerson363] synonym: "curler" RELATED [] is_a: WBPhenotype:0000001 ! body posture variant is_a: WBPhenotype:0004017 ! locomotor coordination variant [Term] id: WBPhenotype:0000566 name: ventral coiler def: "A coiling body that bends ventrally." [WB:WBPerson363] synonym: "ventral curler" RELATED [] is_a: WBPhenotype:0000565 ! coiler [Term] id: WBPhenotype:0000567 name: dorsal coiler def: "A coiling body that bends dorsally." [WB:WBperson363] synonym: "dorsal curler" RELATED [] is_a: WBPhenotype:0000565 ! coiler [Term] id: WBPhenotype:0000568 name: axon ultrastructure variant def: "Animals display variations in the structure or organization of the components of the axon, compared to that observed in control animals." [WB:WBPaper00001499, WB:WBPerson712] synonym: "axon ultrastructure abnormal" NARROW [] is_a: WBPhenotype:0000180 ! axon morphology variant [Term] id: WBPhenotype:0000569 name: axon varicosities def: "Animals display markedly swollen areas along their axons, which are larger than synaptic varicosities in control animals." [WB:WBPaper00001499, WB:WBPaper00024595, WB:WBPerson712] is_a: WBPhenotype:0000568 ! axon ultrastructure variant [Term] id: WBPhenotype:0000570 name: axon cisternae def: "Axons of animals contain flattened membrane-bound compartments. In C. elegans, these cisternae-like structures are typically absent." [WB:WBPaper00001499, WB:WBPaper00024595, WB:WBPerson712] is_a: WBPhenotype:0000568 ! axon ultrastructure variant [Term] id: WBPhenotype:0000571 name: axon vesicle variant def: "Axons of animals exhibit variations in the gross structure or organization of its spherical, membrane-bound, fluid-filled organelles, compared to that observed in control animals." [WB:WBPaper00001499, WB:WBPerson712] synonym: "abnormal axon vesicle" NARROW [] is_a: WBPhenotype:0000568 ! axon ultrastructure variant [Term] id: WBPhenotype:0000572 name: neuronal outgrowth variant def: "Any variation in the processes that govern the extension of neuronal projections." [WB:WBPerson2021] synonym: "neuronal outgrowth abnormal" NARROW [] is_a: WBPhenotype:0000816 ! neuron development variant [Term] id: WBPhenotype:0000573 name: neuronal branching variant synonym: "neuronal branching abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000574 name: excretory canal short def: "The structure made by the processes of the excretory canal cell is reduced in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000704 ! excretory canal morphology variant [Term] id: WBPhenotype:0000575 name: organ system physiology variant def: "Animals exhibit variations in a physical or chemical process required for organs or tissues to carry out their normal functions or for their ability to perceive and respond to stimuli compared to control." [GO:0003008] subset: phenotype_slim_wb synonym: "organ system physiology abnormal" NARROW [] is_a: WBPhenotype:0000519 ! physiology variant [Term] id: WBPhenotype:0000576 name: organism physiology variant def: "Animals exhibit variations in any physical or chemical process required for the organism to carry out its normal function or be able to perceive and respond to stimuli." [WB:WBPerson712] subset: phenotype_slim_wb synonym: "organism physiology abnormal" NARROW [] is_a: WBPhenotype:0000519 ! physiology variant [Term] id: WBPhenotype:0000577 name: organism homeostasis metabolism variant def: "Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the organism compared to control." [GO:0048871, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "organism homeostasis metabolism abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism physiology variant [Term] id: WBPhenotype:0000578 name: body axis development variant def: "Variations in the progression of a discrete axis of an animal's anatomy over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body axis development abnormal" NARROW [] is_a: WBPhenotype:0000528 ! body region development variant [Term] id: WBPhenotype:0000579 name: organism segment development variant def: "Variations in the progression of the overall structure or appearance of any anterior/posterior section of an animal's anatomy over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism segment development abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism development variant [Term] id: WBPhenotype:0000580 name: organism segment behavior variant def: "Variations in the specific actions or reactions of a certain body region of an animal in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism segment behavior abnormal" NARROW [] is_a: WBPhenotype:0000522 ! organism region behavior variant [Term] id: WBPhenotype:0000581 name: body axis morphology variant def: "Animals exhibit variations in the form, structure or composition of a discrete axis (dorsal/ventral/anterior/posterior/transverse) of their anatomy, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body axis morphology abnormal" NARROW [] is_a: WBPhenotype:0000532 ! body region morphology variant [Term] id: WBPhenotype:0000582 name: organism segment morphology variant def: "Animals exhibit variations in the form, structure or composition of any anterior/posterior section of their anatomy compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism segment morphology abnormal" NARROW [] is_a: WBPhenotype:0000535 ! organism morphology variant [Term] id: WBPhenotype:0000583 name: dumpy def: "Worms are shorter and stouter than control animals at the same developmental stage." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497] synonym: "Dpy" BROAD [] is_a: WBPhenotype:0001726 ! body length variant is_a: WBPhenotype:0001727 ! body width variant [Term] id: WBPhenotype:0000584 name: synaptic transmission variant def: "Any variation in the process of communication across a synapse between a neuron and a target cell (neuron, muscle, or secretory cell) compared to control animals." [GO:0007268, WB:cab] synonym: "synaptic input abnormal" NARROW [] synonym: "synaptic input variant" EXACT [] synonym: "synaptic output abnormal" NARROW [] synonym: "synaptic output variant" EXACT [] synonym: "synaptic transmission abnormal" NARROW [] is_a: WBPhenotype:0000816 ! neuron development variant is_a: WBPhenotype:0002020 ! transmission of nerve impulse variant [Term] id: WBPhenotype:0000585 name: cell homeostasis metabolism variant def: "Variations in the chemical reactions and pathways involved in the maintenance of a steady-state at the level of the cell compared to control." [GO:0019725, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell homeostasis metabolism abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000586 name: bleach hypersensitive def: "Animals respond to bleach at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000524 ! bleach response variant [Term] id: WBPhenotype:0000587 name: lectin staining variant synonym: "lectin staining abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000588 name: no male variantity scored synonym: "no male abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000589 name: no hermaphrodite variantity scored synonym: "no hermaphrodite abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000590 name: cell corpse number variant def: "Animals exhibit differences in the number of cell corpses compared to controls at the same developmental life stage." [WB:WBPerson712] synonym: "cell corpse number abnormal" NARROW [] is_a: WBPhenotype:0000730 ! apoptosis variant [Term] id: WBPhenotype:0000591 name: metal response variant def: "Animals exhibit variations in their response to a specific metal compared to that observed in control animals." [WB:WBPerson557] synonym: "metal response abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0000592 name: copper response variant def: "Animals exhibit variations in their response to copper compared to that observed in control animals." [WB:WBPerson557] synonym: "copper response abnormal" NARROW [] is_a: WBPhenotype:0000591 ! metal response variant [Term] id: WBPhenotype:0000593 name: copper hypersensitive def: "Animals respond to copper at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000592 ! copper response variant [Term] id: WBPhenotype:0000594 name: cell migration variant def: "Any variation in the orderly movement of a cell from one site to another." [GO:0016477, WB:cab] subset: phenotype_slim_wb synonym: "cell migration abnormal" NARROW [] synonym: "Mig" BROAD [] synonym: "migration of cells abnormal" RELATED [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000595 name: head behavior variant def: "Variations in the specific actions or reactions of the head in response to external or internal stimuli compared to that observed in control animals." [WB:cab, WB:WBPerson2021, WB:WBPerson557] synonym: "head behavior abnormal" NARROW [] is_a: WBPhenotype:0000580 ! organism segment behavior variant [Term] id: WBPhenotype:0000596 name: body behavior variant def: "Activity characteristic of the body is altered compared to control." [WB:cab] synonym: "body behavior abnormal" NARROW [] is_a: WBPhenotype:0000580 ! organism segment behavior variant [Term] id: WBPhenotype:0000597 name: tail behavior variant def: "Variations in the specific actions or reactions of the tail in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "tail behavior abnormal" NARROW [] is_a: WBPhenotype:0000580 ! organism segment behavior variant [Term] id: WBPhenotype:0000598 name: alimentary system morphology variant def: "Variations in the form, structure or composition of the series of related tissues lying within the body cavity and devoted to feeding and digestion compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "alimentary system morphology abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ system morphology variant [Term] id: WBPhenotype:0000599 name: coelomic system morphology variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the coelomic system, compared to control. The coelom is the fluid compartment that is in contact with internal organ." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "coelomic system morphology abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ system morphology variant [Term] id: WBPhenotype:0000600 name: epithelial system morphology variant def: "Variations in the form, composition or structure of the epithelial system that serves to protect the organism from the external environment compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "epithelial system morphology abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ system morphology variant [Term] id: WBPhenotype:0000601 name: excretory secretory system morphology variant def: "Variations in the form, structure or composition of related tissues that allow the animal to secrete saline fluid and maintain a proper salt balance compared to control. In C. elegans, four cell types (1 pore cell, 1 duct cell, 1 canal cell and a fused pair of gland cells) make up the excretory system (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "excretory secretory system morphology abnormal" NARROW [] synonym: "excretory system morphology abnormal" NARROW [] synonym: "excretory system morphology variant" EXACT [] is_a: WBPhenotype:0000534 ! organ system morphology variant [Term] id: WBPhenotype:0000603 name: muscle system morphology variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the muscle system, compared to control. The muscle system consists of tissues made up of various elongated cells that are specialized to contract and produce movement and mechanical work." [GO:0007517, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "muscle system morphology abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ system morphology variant [Term] id: WBPhenotype:0000604 name: nervous system morphology variant def: "Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals." [WB:WBPerson712] comment: WB:WBbt:0005735. subset: phenotype_slim_wb synonym: "nervous system morphology abnormal" NARROW [] synonym: "neuroanatomical defective" RELATED [] is_a: WBPhenotype:0000534 ! organ system morphology variant [Term] id: WBPhenotype:0000605 name: reproductive system morphology variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "reproductive system morphology abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ system morphology variant [Term] id: WBPhenotype:0000606 name: alimentary system physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the alimentary system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "alimentary system physiology abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ system physiology variant [Term] id: WBPhenotype:0000607 name: coelomic system physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the coelomic system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "coelomic system physiology abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ system physiology variant [Term] id: WBPhenotype:0000608 name: epithelial system physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the epithelial system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "epithelial system physiology abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ system physiology variant [Term] id: WBPhenotype:0000609 name: excretory secretory system physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the excretory/secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "excretory secretory system physiology abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ system physiology variant [Term] id: WBPhenotype:0000610 name: excretory system physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "excretory system physiology abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ system physiology variant [Term] id: WBPhenotype:0000611 name: muscle system physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "muscle system physiology abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ system physiology variant [Term] id: WBPhenotype:0000612 name: nervous system physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the nervous system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "nervous system physiology abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ system physiology variant [Term] id: WBPhenotype:0000613 name: reproductive system physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the reproductive system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "reproductive system physiology abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ system physiology variant [Term] id: WBPhenotype:0000614 name: GLR development variant def: "Any variation in the progression of the GLR accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "GLR development abnormal" NARROW [] is_a: WBPhenotype:0000942 ! accessory cell development variant [Term] id: WBPhenotype:0000615 name: cilia morphology variant def: "Animals exhibit variations in the structure or organization of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. In C. elegans, cilia are classified as channel cilia or wing cilia depending on their placement within the sensillum. Channel cilia of control animals are cylindrical, extend into the sensillum pore and are exposed to the outside. Wing cilia of control animals vary in shape, are embedded in the sensillum sheath cell and are not typically refractory to dyes indicating exposure to the outside." [WB:WBPaper00000214, WB:WBPaper00000932, WB:WBPerson712] synonym: "cilia morphology abnormal" NARROW [] synonym: "defective dye filling of cilia" RELATED [] is_a: WBPhenotype:0001526 ! ciliated neuron morphology variant [Term] id: WBPhenotype:0000616 name: synapse morphology variant def: "Animals display variations in the appearance of the subcellular junctional structure composed of a presynaptic terminal directly opposite the post-synaptic target and separated by a synaptic cleft." [GO:0045202, WB:WBPaper00027305, WB:WBPerson712] synonym: "synapse morphology abnormal" NARROW [] is_a: WBPhenotype:0000604 ! nervous system morphology variant [Term] id: WBPhenotype:0000617 name: alimentary system development variant def: "Any variation in the progression of the alimentary system over time, from its formation to its mature state compared to control. The alimentary system includes all the body structures involved in preparing food for absorption into the body and excretion of waste products." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "alimentary system development abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ system development variant [Term] id: WBPhenotype:0000618 name: coelomic system development variant def: "Any variation in the progression of the coelomic system over time, from its formation to its mature state compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "coelomic system development abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ system development variant [Term] id: WBPhenotype:0000619 name: epithelial system development variant def: "Any variation in the progression of the epithelial system over time, from its formation to its mature state compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "epithelial system development abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ system development variant [Term] id: WBPhenotype:0000620 name: excretory secretory system development variant def: "Any variation in the progression of the excretory secretory system over time, from its formation to its mature state compared to control. The excretory secretory system consists of the excretory system and its associated glands." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "excretory secretory system development abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ system development variant [Term] id: WBPhenotype:0000621 name: excretory system development variant def: "Variations in the progression of the excretory system over time, from its formation to the mature structure. The excretory system is required for the elimination of metabolic waste. In C. elegans, the excretory system is comprised of the excretory cell, excretory duct cell and excretory socket cell." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "excretory system development abnormal" NARROW [] is_a: WBPhenotype:0000620 ! excretory secretory system development variant [Term] id: WBPhenotype:0000622 name: muscle system development variant def: "Any variation in the progression of the muscle system over time, from its formation to its mature state compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "muscle system development abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ system development variant [Term] id: WBPhenotype:0000623 name: nervous system development variant def: "Any variation in the progression of nervous tissue over time, from its formation to its mature state compared to control." [GO:0007399, WB:cab] subset: phenotype_slim_wb synonym: "nervous system development abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ system development variant [Term] id: WBPhenotype:0000624 name: reproductive system development variant def: "Any variation in the progression of the reproductive system over time, from its formation to its mature state compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "reproductive defect" RELATED [] synonym: "reproductive system development abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ system development variant [Term] id: WBPhenotype:0000625 name: synaptogenesis variant def: "Any variation in the biosynthesis of a synapse compared to control." [GO:0007416, WB:cab] synonym: "synaptogenesis abnormal" NARROW [] is_a: WBPhenotype:0000623 ! nervous system development variant [Term] id: WBPhenotype:0000626 name: habituation variant def: "Any variation in the decrease in a behavioral response to a repeated stimulus compared to control." [GO:0046959, WB:cab] subset: phenotype_slim_wb synonym: "habituation abnormal" NARROW [] synonym: "non associative learning" RELATED [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000627 name: anesthetic response variant def: "Animals exhibit variations in their response to a specific anesthetic compared to that observed in control animals." [WB:WBPerson557] synonym: "anaesthetic response variant" EXACT [] synonym: "anesthetic response abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0000628 name: spindle assembly defective early emb def: "Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GO:0051225, WB:cab, WB:cgc7141, WB:WBPerson2021] comment: Possible XP. synonym: "Emb" BROAD [] synonym: "spindle assembly abnormal" NARROW [] is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb [Term] id: WBPhenotype:0000629 name: ectopic neurite outgrowth def: "Any variation that causes an increase in the frequency of neurite (axon or dendrite) outgrowth. As a result, an excess number of neuronal projections are generated." [WB:WBPerson2021] is_a: WBPhenotype:0000572 ! neuronal outgrowth variant [Term] id: WBPhenotype:0000630 name: quinine chemotaxis defective def: "Failure to execute the characteristic response to the bitter tastant quinine, as defined by control animals. In C. elegans, quinine is typically repellent." [WB:WBPaper00006481, WB:WBPaper00035961, WB:WBPerson712] is_a: WBPhenotype:0001449 ! aqueous negative chemotaxis defective is_a: WBPhenotype:0001454 ! quinine chemotaxis variant [Term] id: WBPhenotype:0000631 name: drug response variant def: "Any variation in the characteristic response(s) to drug(s) as defined by control animals." [WB:cab] synonym: "drug response abnormal" RELATED [] synonym: "drug response abnormal" NARROW [] is_a: WBPhenotype:0000523 ! chemical response variant [Term] id: WBPhenotype:0000632 name: axon fasciculation variant def: "The ability of axons to converge and form a bundle of nerve fibres (fascicle) is compromised." [GO:0007413, WB:WBPerson2021] synonym: "axon fasciculation abnormal" NARROW [] is_a: WBPhenotype:0000880 ! axon development variant [Term] id: WBPhenotype:0000633 name: axon branching variant def: "Animals display variations in the number or pattern of axonal tracts stemming from the neuron cell body, compared to that observed in control animals." [GO:0048755, WB:WBPaper00027335, WB:WBPaper00027711, WB:WBPerson712] synonym: "axon branching abnormal" NARROW [] is_a: WBPhenotype:0000180 ! axon morphology variant is_a: WBPhenotype:0001224 ! axon outgrowth variant [Term] id: WBPhenotype:0000634 name: pharyngeal pumping variant def: "Any variation in the contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes compared to control." [GO:0043050, WB:cab] subset: phenotype_slim_wb synonym: "pharyngeal pumping abnormal" NARROW [] is_a: WBPhenotype:0002056 ! eating variant [Term] id: WBPhenotype:0000635 name: positive chemotaxis variant def: "Any variation in the directed movement of an animal in response to chemical attractants as defined by control animals." [GO:0050918, WB:cab, WB:cgc122, WB:cgc387] synonym: "positive chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001434 ! chemotaxis variant [Term] id: WBPhenotype:0000636 name: neuron degeneration variant def: "Any variation in the ability of neurons to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles under conditions that ellicit this response in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuron degeneration abnormal" NARROW [] is_a: WBPhenotype:0000612 ! nervous system physiology variant [Term] id: WBPhenotype:0000637 name: dauer formation variant def: "Characteristic entry into the dauer stage is altered compared to control animals." [WB:cab] synonym: "Daf" BROAD [] synonym: "dauer formation abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer arrest variant is_a: WBPhenotype:0000308 ! dauer development variant [Term] id: WBPhenotype:0000638 name: molt defect def: "Animals exhibit defects in the process of periodic shedding, of part or all of its cuticle, during cuticle replacement that punctuates each larval stage." [GO:0018996, WB:WBPerson712] synonym: "Mlt" BROAD [] synonym: "Mult" BROAD [] is_a: WBPhenotype:0002041 ! molt variant [Term] id: WBPhenotype:0000639 name: temperature induced dauer formation variant def: "Animals exhibit variations in the entry into the dauer stage when exposed to temperatures that induce dauer formation in control animals. In C. elegans, many Daf-c animals enter dauer at 25C, whereas Hid animals enter dauer at 27C." [WB:WBPaper00006103, WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712] synonym: "Hid" RELATED [] synonym: "temperature induced dauer formation abnormal" NARROW [] is_a: WBPhenotype:0000146 ! organism temperature response variant is_a: WBPhenotype:0001539 ! dauer induction variant [Term] id: WBPhenotype:0000640 name: egg laying variant def: " Animals exhibit variations in the stage of eggs laid, egg laying cycle, number of eggs or egg laying in response to stimuli compared to control." [pmid:11813735, pmid:9697864, WB:cab] comment: Visual inspection. subset: phenotype_slim_wb synonym: "egg laying abnormal" NARROW [] synonym: "Egl" BROAD [] synonym: "oviposition abnormal" RELATED [GO:0018991] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000641 name: activity level variant def: "Any variation in the degree of movement compared to control animals." [WB:cab] synonym: "activity level abnormal" NARROW [] is_a: WBPhenotype:0000643 ! locomotion variant [Term] id: WBPhenotype:0000642 name: hyperactive def: "Worms move forward or backward with an increased rate of body bends per minute compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00006395] synonym: "Hya" BROAD [] is_a: WBPhenotype:0000641 ! activity level variant [Term] id: WBPhenotype:0000643 name: locomotion variant def: "Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712] subset: phenotype_slim_wb synonym: "locomotion abnormal" NARROW [] synonym: "movement defect" RELATED [] synonym: "Unc" BROAD [] synonym: "uncoordinated" RELATED [] is_a: WBPhenotype:0001206 ! movement variant [Term] id: WBPhenotype:0000644 name: paralyzed def: "Animals do not move and are not responsive to external mechanical stimulation." [WB:cab] subset: phenotype_slim_wb synonym: "Prl" BROAD [] synonym: "Prz" RELATED [] is_a: WBPhenotype:0001213 ! locomotion reduced [Term] id: WBPhenotype:0000645 name: roller def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern. In liquid media, wave propogation is helical rather than planar." [WB:cab, WB:cgc31] synonym: "Rol" BROAD [] is_a: WBPhenotype:0004017 ! locomotor coordination variant [Term] id: WBPhenotype:0000646 name: sluggish def: "Animals move more slowly compared with control animals." [WB:cab] synonym: "lethargic" RELATED [] synonym: "slow" RELATED [] synonym: "Slu" BROAD [] is_a: WBPhenotype:0001213 ! locomotion reduced [Term] id: WBPhenotype:0000647 name: copulation variant def: "Animals exhibit variations in any processes that lead to the successful transfer of sperm from one organism to another." [GO:0007620, WB:cab] subset: phenotype_slim_wb synonym: "copulation abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000648 name: male mating variant def: "Any varaition in the specific actions or reactions of the male that are associated with reproduction compared to control." [GO:0060179, WB:cab] synonym: "Cod" BROAD [] synonym: "male mating abnormal" NARROW [] is_a: WBPhenotype:0000647 ! copulation variant is_a: WBPhenotype:0000888 ! male behavior variant [Term] id: WBPhenotype:0000649 name: vulva location variant def: "Any variation in the male's ability to locate his partner's vulva when backing along the ventral side of the partner during mating compared to control. In C. elegans the male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [GO:0034608, WB:WBPerson2021, WB:WBPerson557] synonym: "Lov" RELATED [] synonym: "vulva location abnormal" NARROW [] is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant [Term] id: WBPhenotype:0000650 name: defecation variant def: "Animals exhibit variations in the processes involved in eliminating gut contents compared to control animals. In C. elegans the sequence of events during defecation includes posterior body contraction (pBoc), relaxation, anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp), and intercycle period (Wormatlas)." [GO:0030421, WB:cab, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "defecation abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000651 name: constipated def: "Animals exhibit delayed or infrequent passage and/or expulsion of fecal matter." [WB:WBPerson2021] synonym: "Con" BROAD [] is_a: WBPhenotype:0000650 ! defecation variant [Term] id: WBPhenotype:0000652 name: sensory system variant def: "Variations in the progression of a set of interacting or interdependent entities forming the sensory system over time from an initial condition to a later condition compared to control animals. The sensory system is involved in the perception of a stimuli, its conversion into a signal and the recognition and characterization of the resulting signal." [WB:WBPerson2021, WB:WBPerson557] synonym: "sensory system abnormal" NARROW [] is_a: WBPhenotype:0000612 ! nervous system physiology variant [Term] id: WBPhenotype:0000653 name: mechanosensory system variant def: "Variations in the progression of a set of interacting or interdependent entities forming the mechanosensory system over time from an initial condition to a later condition compared to control animals. The mechanosensory system is involved in the perception of a mechanical stimuli, its conversion into a signal and the recognition and characterization of the resulting signal." [WB:WBPerson2021, WB:WBPerson557] synonym: "mechanosensory system abnormal" NARROW [] is_a: WBPhenotype:0000652 ! sensory system variant [Term] id: WBPhenotype:0000654 name: synaptic vesicle exocytosis variant def: "Animals exhibit variations in the fusion of intracellular neurotransmitter-filled membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell compared to control." [GO:0016079, WB:WBPerson712] synonym: "synaptic vesicle exocytosis abnormal" NARROW [] is_a: WBPhenotype:0000728 ! exocytosis variant is_a: WBPhenotype:0001684 ! synaptic vesicle homeostasis variant [Term] id: WBPhenotype:0000655 name: GABA synaptic transmission variant def: "Animals exhibit variations in the process of GABA neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control." [GO:0007268, WB:WBPerson712] synonym: "GABA synaptic transmission abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic transmission variant [Term] id: WBPhenotype:0000656 name: acetylcholine synaptic transmission variant def: "Animals exhibit variations in the process of acetylcholine neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control." [GO:0007268, WB:WBPerson712] synonym: "acetylcholine synaptic transmission abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic transmission variant [Term] id: WBPhenotype:0000657 name: neuronal synaptic transmission variant def: "Any variation in the process of information transfer between two neurons; usually in reference to chemical synapses, but can also be used to refer to electrical synapses compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuronal synaptic transmission abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic transmission variant [Term] id: WBPhenotype:0000658 name: neuromuscular synaptic transmission variant def: "Any variation in the process of communication across a synapse between a neuron and a target muscle cell compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuromuscular synaptic transmission abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic transmission variant [Term] id: WBPhenotype:0000659 name: feeding behavior variant def: "Behavior associated with the intake of food is altered compared to control." [GO:0007631, WB:WBPerson557] subset: phenotype_slim_wb synonym: "feeding behavior abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000660 name: social feeding increased def: "Worms are found in clumps and/or crowded at the border of the bacterial lawn more frequently than control animals. This behavior is not due to mobility defects." [WB:WBPerson712] synonym: "bordering increased" RELATED [] synonym: "social behavior enhanced" RELATED [] is_a: WBPhenotype:0000659 ! feeding behavior variant is_a: WBPhenotype:0001291 ! social behavior variant [Term] id: WBPhenotype:0000661 name: solitary feeding increased def: "Animals disperse across a bacterial lawn and feed alone. When food is limiting, they can aggregate into swarms or clumps, but disperse once again when food is absent." [WB:WBPaper00003187, WB:WBPaper00032342, WB:WBPerson712] synonym: "solitary behavior enhanced" RELATED [] synonym: "solitary forager on food" RELATED [] is_a: WBPhenotype:0000659 ! feeding behavior variant is_a: WBPhenotype:0001291 ! social behavior variant [Term] id: WBPhenotype:0000662 name: foraging behavior variant def: "Variations in the behavior by which an organism locates food compared to control animals. In C. elegans roaming or dwelling activity on food are two examples of parameters used to assess this behavior. Roaming is defined as moving in a high-speed forward direction with brief backward movement, often traversing wide regions. Dwelling is defined as low-speed/high turning movement restricted to a confined region." [GO:0060756, WB:WBPaper00005621, WB:WBPaper00031455, WB:WBPerson712] subset: phenotype_slim_wb synonym: "Fab" BROAD [] synonym: "foraging behavior abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000663 name: osmotic avoidance variant def: "Animals exhibit variations in the avoidance response to solutions of a particular osmotic strength compared to control. In C. elegans, animals typically avoid solutions of high osmotic strength." [WB:WBPerson2021] synonym: "Osm" RELATED [] synonym: "osmotic avoidance abnormal" NARROW [] is_a: WBPhenotype:0000481 ! negative chemotaxis variant [Term] id: WBPhenotype:0000664 name: exaggerated body bends def: "The maximum ventral and dorsal flex of the animal is greater than that observed for control animals." [WB:WBPerson712] synonym: "exaggerated body bends" EXACT [] synonym: "loopy" RELATED [] synonym: "Lpy " RELATED [] is_a: WBPhenotype:0001703 ! body bend variant [Term] id: WBPhenotype:0000665 name: connection of gonad variant def: "Any variation that disrupts the connectivity between the somatic gonad and the adjoining tissues compared to control. In C. elegans this connnection is between the somatic gonad and the vulva in hermaphrodites and between the somatic gonad and proctodeum in males." [WB:WBPerson2021, WB:WBPerson557] synonym: "Cog" RELATED [] synonym: "connection of gonad abnormal" NARROW [] is_a: WBPhenotype:0000605 ! reproductive system morphology variant [Term] id: WBPhenotype:0000666 name: ovulation variant def: "Any variation that disrupts the release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control." [GO:0030728, WB:WBPaper00003017, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "ovulation abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000667 name: gonad displaced def: "The specialized tissue of the reproductive tract that produces gamete is shifted from its customary place as defined by control." [WB:WBPerson2021, WB:WBPerson557] synonym: "ectopic gonad" RELATED [] is_a: WBPhenotype:0000977 ! somatic gonad morphology variant [Term] id: WBPhenotype:0000668 name: endomitotic oocytes def: "Any variation that results in the presence of mature oocytes with distended polyploid nuclei. In C. elegans, such oocytes mature and exit diakinesis, but are often not properly ovulated or fertilized." [WB:kmva] synonym: "arrest in meiosis I" RELATED [] synonym: "Emo" BROAD [] is_a: WBPhenotype:0001260 ! oocyte morphology variant [Term] id: WBPhenotype:0000669 name: sex muscle development variant def: "Variations in the progression of the muscles of the adult reproductive system over time form their initial formation to their mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "sex muscle development abnormal" NARROW [] is_a: WBPhenotype:0000624 ! reproductive system development variant is_a: WBPhenotype:0000860 ! nonstriated muscle development variant [Term] id: WBPhenotype:0000670 name: spermatogenesis variant def: "Any variation in the processes that influence the generation and maturation of spermatozoa (motile sperm) compared to control." [GO:0007283, WB:WBPaper00027300, WB:WBPerson2021] synonym: "Spe" BROAD [] synonym: "spermatocyte germ cell differentiation abnormal" EXACT [] synonym: "spermatogenesis abnormal" NARROW [] is_a: WBPhenotype:0000894 ! germ cell differentiation variant [Term] id: WBPhenotype:0000671 name: resistant to copper def: "Animals fail to respond to the concentration of copper that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to copper to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000592 ! copper response variant [Term] id: WBPhenotype:0000672 name: presynaptic vesicle cluster localization variant def: "Animals display variations in the distribution of transmitter-filled vesicles in relation to the electron-dense membrane specialization of the neuron,compared to that observed in control animals." [WB:WBPaper00027305, WB:WBPaper00027711, WB:WBPerson712] synonym: "presynaptic vesicle cluster localization abnormal" NARROW [] synonym: "synaptic vesicle cluster localization abnormal" RELATED [] is_a: WBPhenotype:0000102 ! presynaptic vesicle cluster variant [Term] id: WBPhenotype:0000673 name: brood size variant def: "The number of offspring produced is altered compared to that of control animals." [WB:WBPerson557] synonym: "brood size abnormal" NARROW [] is_a: WBPhenotype:0000806 ! hermaphrodite fertility variant [Term] id: WBPhenotype:0000674 name: slow development def: "The developmental progression of an animal, from its formation to its mature structure occurs over a longer time period compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "retarded development" RELATED [] is_a: WBPhenotype:0000438 ! retarded heterochronic variations [Term] id: WBPhenotype:0000675 name: zygotic lethal def: "Animals die after fusion of gametes without dividing." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" RELATED [] is_a: WBPhenotype:0000213 ! zygotic development variant [Term] id: WBPhenotype:0000676 name: growth rate variant def: "The increase in size or mass of an organism over time during the lifespan of the organism or over any developmental stage(s) is not similar to that observed for control animals." [GO:0040007, WB:WBPerson712] synonym: "growth rate abnormal" NARROW [] is_a: WBPhenotype:0000030 ! growth variant [Term] id: WBPhenotype:0000677 name: chemosensation defective def: "Animals fail to receive, process or recognize a sensory chemical stimulus in the same manner as control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001050 ! chemosensation variant [Term] id: WBPhenotype:0000678 name: no copper sensitivity is_obsolete: true [Term] id: WBPhenotype:0000679 name: transgene subcellular localization variant def: "Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] synonym: "transgene subcellular localization abnormal" NARROW [] is_a: WBPhenotype:0000961 ! pattern of transgene expression variant [Term] id: WBPhenotype:0000680 name: aldicarb response variant def: "Animals exhibit variations in their response to aldicarb compared to that observed in control animals." [WB:WBPerson557] synonym: "aldicarb response abnormal" NARROW [] is_a: WBPhenotype:0001290 ! acetylcholinesterase inhibitor response variant [Term] id: WBPhenotype:0000681 name: DMPP response variant def: "Animals exhibit variations in their response to DMPP compared to that observed in control animals." [WB:WBPerson557] synonym: "DMPP response abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0000682 name: feminization of germline def: "Hermaphrodites are transformed into fertile females; In C. elegans, XO fog animals are somatically male but produce oocytes instead of, or in addition to, sperm." [pmid:3396865, WB:cab] synonym: "feminization of germ line" EXACT [] synonym: "Fog" BROAD [] is_a: WBPhenotype:0000687 ! feminization of XX and XO animals is_a: WBPhenotype:0000812 ! germ cell development variant [Term] id: WBPhenotype:0000683 name: masculinization of germline def: " The germ line is sexually transformed from hermaphrodite to male. In C. elegans, XX mog animals are somatically hermaphrodite, but germ cells that normally would become oocytes are transformed into sperm." [WB:WBPaper00001710, WB:WBPerson2021] synonym: "masculinization of germ line" EXACT [] synonym: "Mog" BROAD [] is_a: WBPhenotype:0000812 ! germ cell development variant is_a: WBPhenotype:0001572 ! masculinized [Term] id: WBPhenotype:0000684 name: fewer germ cells def: "Germ cell populations are reduced compared to control animals." [WB:cab, WB:WBPerson2021] synonym: "Fgc" BROAD [] synonym: "germline underproliferation" RELATED [] is_a: WBPhenotype:0000823 ! germline proliferation variant [Term] id: WBPhenotype:0000685 name: larval growth slow def: "Any variation that causes a reduction in growth rate during larval stages compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000438 ! retarded heterochronic variations is_a: WBPhenotype:0001016 ! larval growth variant [Term] id: WBPhenotype:0000686 name: organism ionizing radiation response variant def: "Animals exhibit variations in their response ionizing radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "organism ionizing radiation response abnormal" NARROW [] synonym: "reactive oxygen species abnormal" BROAD [WB:WBPaper00031296] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000687 name: feminization of XX and XO animals def: "Both hermaphrodites and males develop into fertile females." [WB:cab] synonym: "Fem" BROAD [] is_a: WBPhenotype:0000049 ! postembryonic development variant is_a: WBPhenotype:0000624 ! reproductive system development variant is_a: WBPhenotype:0000822 ! sex determination variant [Term] id: WBPhenotype:0000688 name: sterile def: "Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712] subset: phenotype_slim_wb synonym: "semi sterile" EXACT [] synonym: "Ste" BROAD [] is_a: WBPhenotype:0001384 ! fertility reduced [Term] id: WBPhenotype:0000689 name: maternal sterile def: " Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557] synonym: "Reduced fecundity of injected worm" EXACT [WB:cgc5599] synonym: "Ste" BROAD [] synonym: "sterile F0 fertility problems" RELATED [] is_a: WBPhenotype:0000694 ! hermaphrodite sterile [Term] id: WBPhenotype:0000690 name: gonad migration variant def: "Variations in the gross movement of the whole structure of the gonad along the bodywall, behind the gonadal leader cell and away from the developing vulva compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Gom" BROAD [] synonym: "gonad migration abnormal" NARROW [] is_a: WBPhenotype:0000624 ! reproductive system development variant [Term] id: WBPhenotype:0000691 name: gonad development variant def: "Variations in the progression of the organ that produces gametes over time, from its formation to the mature structure compared to control." [GO:0008406, WB:WBPerson2021] synonym: "Gon" RELATED [] synonym: "gonad development abnormal" NARROW [] synonym: "gonadogenesis abnormal" RELATED [] is_a: WBPhenotype:0000624 ! reproductive system development variant [Term] id: WBPhenotype:0000692 name: male sterile def: "X0 animals fail to generate viable cross-progeny." [WB:WBPerson2021] is_a: WBPhenotype:0000688 ! sterile is_a: WBPhenotype:0000863 ! male fertility reduced [Term] id: WBPhenotype:0000693 name: male sperm fertilization defect def: "Any perturbation that renders male derived sperm ineffective at fertilizing an oocyte." [WB:WBPaper00001075, WB:WBPerson2021] synonym: "Fer" BROAD [] is_a: WBPhenotype:0000692 ! male sterile [Term] id: WBPhenotype:0000694 name: hermaphrodite sterile def: "Hermaphrodites fail to generate viable self-progeny and/or cross-progeny." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000688 ! sterile is_a: WBPhenotype:0001259 ! hermaphrodite fertility reduced [Term] id: WBPhenotype:0000695 name: vulva morphology variant def: "Animals exhibit variations in the gross structure or organization of the reproductive organ required for depositing eggs and for influencing male mating behavior compared to control." [WB:WBPerson712] synonym: "vulva morphology abnormal" NARROW [] is_a: WBPhenotype:0001335 ! hermaphrodite reproductive system morphology variant [Term] id: WBPhenotype:0000696 name: everted vulva def: "The eversion process, in which the vulval invagination is turned inside out during the final molt, is disrupted. In C.elegans, such variations in vulval eversion are primarily due to developmental defects in the somatic gonad (and sometimes vulva)." [WB:cab, WB:WBPaper00001738, WB:WBPerson2021, WB:WBPerson261] synonym: "Evl" BROAD [] is_a: WBPhenotype:0000695 ! vulva morphology variant [Term] id: WBPhenotype:0000697 name: protruding vulva def: "Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva." [WB:WBPaper00004408, WB:WBPerson2021] synonym: "Pvl" BROAD [] synonym: "Pvu" BROAD [] is_a: WBPhenotype:0000695 ! vulva morphology variant [Term] id: WBPhenotype:0000698 name: vulvaless def: "No vulval tissue is produced. In C. elegans, this is usually a result of all six vulval precursor cells adopting a tertiary fate." [WB:WBPaper00001182, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "underinduced" EXACT [] synonym: "Vul" BROAD [] is_a: WBPhenotype:0000219 ! vulval cell induction reduced [Term] id: WBPhenotype:0000699 name: vulva development variant def: "Variations in the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure compared to control. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GO:0040025, WB:IA, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "vulva development abnormal" NARROW [] is_a: WBPhenotype:0000624 ! reproductive system development variant [Term] id: WBPhenotype:0000700 name: multivulva def: "Multiple vulva-like protrusions are present along the ventral side of the animal. In C. elegans, this is usually a result of all six vulval precursor cells adopting primary or secondary vulval fates." [WB:WBPaper00001182, WB:WBPerson2021] synonym: "Muv" BROAD [] synonym: "overinduced" EXACT [] is_a: WBPhenotype:0000218 ! vulval cell induction increased [Term] id: WBPhenotype:0000701 name: epithelial development variant def: "Any variation in the progression of the epithelia over time, from its formation to its mature state compared to control. This process involves autonomously generated changes in epidermal cell shape and position, and interactions with internal tissues, including the developing nervous system and body wall muscles to affect epidermal enclosure, cell intercalation, and epidermal elongation." [WB:WBPerson2021, WB:WBPerson557] synonym: "epidermal morphogenesis variant" RELATED [] synonym: "epithelial development abnormal" NARROW [] synonym: "hypodermal development abnormal" RELATED [] is_a: WBPhenotype:0000619 ! epithelial system development variant [Term] id: WBPhenotype:0000702 name: epithelial cell fusion failure def: "Any perturbation that renders epithelial cells incompetent at undergoing membrane fusion during development." [WB:WBPaper00005122, WB:WBPerson2021] xref: PMID:15341747 is_a: WBPhenotype:0000165 ! cell fusion variant is_a: WBPhenotype:0000701 ! epithelial development variant [Term] id: WBPhenotype:0000703 name: epithelial morphology variant def: "Variations in the form, composition or structure of the layer of cells that cover the external surface of an organism and form the inner lining between the tissues and organs of that organism and the external environment compared to control. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "epithelial morphology abnormal" NARROW [] synonym: "hypodermal morphology abnormal" RELATED [] is_a: WBPhenotype:0000600 ! epithelial system morphology variant [Term] id: WBPhenotype:0000704 name: excretory canal morphology variant def: "Variations in the form or composition of structures made by the processes of the excretory canal cell compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory canal morphology abnormal" NARROW [] is_a: WBPhenotype:0000916 ! excretory cell morphology variant [Term] id: WBPhenotype:0000705 name: intestinal cell development variant def: "Any variation in the progression of an intestinal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "intestinal cell development abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant is_a: WBPhenotype:0000708 ! intestinal development variant [Term] id: WBPhenotype:0000706 name: gut granule biogenesis reduced def: "Animals lack birefringent containing compartments in embryonic intestinal cells; however, these compartments appear in adult stages." [WB:WBPaper00032168, WB:WBPerson712] synonym: "Glo" BROAD [] synonym: "gut granule loss" RELATED [] xref: PMID:15843430 is_a: WBPhenotype:0000103 ! gut granule development variant is_a: WBPhenotype:0001430 ! lysosome organization biogenesis variant [Term] id: WBPhenotype:0000707 name: pharyngeal development variant def: "Variations in the progression of the pharynx (feeding organ) over time, from its formation to the mature structure compared to control. In C. elegans the pharynx is divided into the anterior and posterior regions. The anterior region includes the corpus (procorpus and metacorpus - first bulb) and the posterior region includes the isthmus and terminal bulb (second bulb)." [GO:0043282, WB:WBPerson2021] synonym: "pharyngeal development abnormal" NARROW [] is_a: WBPhenotype:0000617 ! alimentary system development variant [Term] id: WBPhenotype:0000708 name: intestinal development variant def: "Variations in the progression of the intestine over time from its initial formation to its mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "endoderm development abnormal" RELATED [] synonym: "gut development abnormal" RELATED [] synonym: "intestinal development abnormal" NARROW [] is_a: WBPhenotype:0000617 ! alimentary system development variant [Term] id: WBPhenotype:0000709 name: pharyngeal morphology variant def: "Variations in the form or composition of the mouthparts at the anterior end of the digestive tract which contain a series of radial muscles, related neurons and epithelial cells, and several gland cells which may aid in digestion compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal morphology abnormal" NARROW [] is_a: WBPhenotype:0000598 ! alimentary system morphology variant [Term] id: WBPhenotype:0000710 name: intestinal morphology variant def: "Animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "intestinal morphology abnormal" NARROW [] is_a: WBPhenotype:0000598 ! alimentary system morphology variant [Term] id: WBPhenotype:0000711 name: organism hypersensitive ionizing radiation def: "Animals exhibit increased sensitivity to the effects of ion producing radiation compared to control animals." [WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0000686 ! organism ionizing radiation response variant [Term] id: WBPhenotype:0000712 name: germ cell ionizing radiation response variant def: "Germ cells exhibit variations in their response to ionizing radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "germ cell ionizing radiation response abnormal" NARROW [] is_a: WBPhenotype:0000987 ! germ cell physiology variant [Term] id: WBPhenotype:0000715 name: muscle excess def: "Animals exhibit a greater number of embryonic muscle cells compared to control." [WB:kmva, WB:WBPaper00001584] synonym: "Mex" BROAD [WB:WBPaper00001584] is_a: WBPhenotype:0000622 ! muscle system development variant [Term] id: WBPhenotype:0000716 name: muscle cell attachment variant def: "Any variation in the connection of a cell whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "muscle cell attachment abnormal" NARROW [] is_a: WBPhenotype:0000990 ! muscle cell physiology variant [Term] id: WBPhenotype:0000717 name: gene expression variant def: "Variations in the processes that convert a gene's coding sequence into a mature gene product or products (proteins or RNA), compared to control." [GO:0010467, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "gene expression abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0000718 name: dosage compensation variant def: "Variations in the process of normalizing the expression level of X-linked genes between XX and XO animals compared to control." [GO:0007549, WB:WBPerson363] comment: Possible XP GO:0007549. synonym: "dosage compensation abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene expression variant [Term] id: WBPhenotype:0000719 name: reporter gene expression variant synonym: "reporter gene expression abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000720 name: pattern of reporter gene expression variant synonym: "pattern of reporter gene expression abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000721 name: level of reporter gene expression variant synonym: "level of reporter gene expression abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000722 name: nucleolus variant def: "Animals exhibit variations in the appearance of nucleoli compared to control animals." [WB:cab] subset: phenotype_slim_wb synonym: "nucleolus abnormal" NARROW [] is_a: WBPhenotype:0001028 ! nuclear appearance variant [Term] id: WBPhenotype:0000724 name: protein secretion variant def: "Variations in the regulated release of proteins from a cell or group of cells compared to control." [GO:0009306, WB:WBPerson2021] synonym: "protein secretion abnormal" NARROW [] is_a: WBPhenotype:0000258 ! cell secretion variant [Term] id: WBPhenotype:0000725 name: lipid metabolism variant def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of lipid within the organism or cell compared to control." [GO:0055088, WB:WBPaper00032000, WB:WBPaper00032082, WB:WBPerson712] synonym: "lipid metabolism abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0000726 name: ligand binding variant def: "Any variation of the specific binding of a molecule to its partner, which typically results in a change in cell activity, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "ligand binding abnormal" NARROW [] is_a: WBPhenotype:0000727 ! enzyme activity variant [Term] id: WBPhenotype:0000727 name: enzyme activity variant def: "Any variation in the function of naturally occurring macromolecular substances known as enzymes compared to control. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [GO:0003824, WB:WBPerson2021, WB:WBPerson557] synonym: "enzyme activity abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0000728 name: exocytosis variant def: "Variations in the process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, compared to control." [GO:0006887, WB:WBPerson2021] synonym: "exocytosis abnormal" NARROW [] is_a: WBPhenotype:0000258 ! cell secretion variant [Term] id: WBPhenotype:0000729 name: cell death variant def: "Animals exhibit variations in any of the processes that lead to the termination of vital functions of a cell." [GO:0008219, WB:cab] subset: phenotype_slim_wb synonym: "Ced" BROAD [] synonym: "cell death abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000730 name: apoptosis variant def: "Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell." [GO:0006915, WB:WBPerson2021] synonym: "apoptosis abnormal" NARROW [] synonym: "Ced" BROAD [] is_a: WBPhenotype:0001172 ! programmed cell death variant [Term] id: WBPhenotype:0000731 name: germ cell hypersensitive ionizing radiation def: "Germ cells exhibit increased sensitivity to the effects of ion producing radiation compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000712 ! germ cell ionizing radiation response variant is_a: WBPhenotype:0001324 ! cell ionizing radiation response variant [Term] id: WBPhenotype:0000732 name: DNA metabolism variant def: "Variations in any process that involves the maintenance, biosynthesis or accumulation of DNA in the organism compared to control." [WB:WBPerson2021] synonym: "DNA metabolism abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0000733 name: catalysis variant def: "Any variation in the catalysis of a biochemical reaction compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [GO:0003824, WB:WBPerson2021, WB:WBPerson557] synonym: "catalysis abnormal" NARROW [] is_a: WBPhenotype:0000727 ! enzyme activity variant [Term] id: WBPhenotype:0000734 name: hypodermal cell physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the hypodermal system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "hypodermal cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000608 ! epithelial system physiology variant [Term] id: WBPhenotype:0000735 name: endoreduplication of hypodermal nuclei variant def: "Any variation in the regulated re-replication of DNA in the hypodermal cells during a single cell cycle, compared to control." [GO:0042023, WB:WBPerson2021, WB:WBPerson557] synonym: "endoreduplication of hypodermal nuclei abnormal" NARROW [] is_a: WBPhenotype:0000734 ! hypodermal cell physiology variant [Term] id: WBPhenotype:0000736 name: autophagy variant def: "Animals exhibit variations in the process by which their cells digest parts of their own cytoplasm, compared to control." [GO:0006914, WB:WBPerson712] synonym: "" NARROW [] synonym: "autophagy abnormal" RELATED [] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0000737 name: germ cell resistant ionizing radiation def: "Germ cells fail to respond to the dosage of ion producing radiation that elicits a response in control animals. Alternatively, germ cells require a higher dosage or a longer exposure to ion producing radiation to elicit the same response as control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000712 ! germ cell ionizing radiation response variant is_a: WBPhenotype:0001324 ! cell ionizing radiation response variant [Term] id: WBPhenotype:0000738 name: organism environmental stimulus response variant def: "The response to a change in the environment is altered compared to control." [WB:cab] subset: phenotype_slim_wb synonym: "organism environmental stimulus response abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0000739 name: DNA damage response variant def: "Variations in the activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism, compared to control." [GO:0006974, WB:WBPerson2021] synonym: "DNA damage response abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell stress response variant [Term] id: WBPhenotype:0000740 name: cell cycle variant def: "Cells of the animals exhibit variations in the initiation, progression or exit from the biochemical and morphological processes that occur during successive replication or nuclear replication events from that observed for control animals." [GO:0007049, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "cell cycle abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000741 name: DNA damage checkpoint variant def: "Mitotic cells exhibit variations in the execution of cell-cycle arrest in response to DNA damage." [WB:WBPaper00029085, WB:WBPerson2021] synonym: "DNA damage checkpoint abnormal" NARROW [] is_a: WBPhenotype:0000740 ! cell cycle variant [Term] id: WBPhenotype:0000742 name: DNA recombination variant def: "Variations in the process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents, compared to control." [GO:0006310, WB:WBPerson2021] synonym: "DNA recombination abnormal" NARROW [] is_a: WBPhenotype:0000732 ! DNA metabolism variant [Term] id: WBPhenotype:0000743 name: RNAi response variant def: "Animals exhibit variations in their response to gene silencing triggered by double stranded RNA (RNAi), compared to control." [GO:0016246, WB:WBPerson2021] synonym: "Rde" BROAD [] synonym: "RNAi response abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0000744 name: transgene induced cosuppression variant def: "Animals exhibit variations in the silencing of endogenous genes after introduction of repetitive exogenous cognate DNA compared to control." [WB:WBPaper00025139, WB:WBPerson2021, WB:WBPerson557] synonym: "transgene induced cosuppression abnormal" NARROW [] is_a: WBPhenotype:0002063 ! maintenance of gene silencing variant [Term] id: WBPhenotype:0000745 name: transposon silencing variant def: "Animals exhibit variations in the activity of endogenous transposons compared to control. In C. elegans transposon activity is often measured by the rate of reversion of mutations induced by transposon insertions." [GO:0000335, WB:WBPaper00031962, WB:WBPerson712] synonym: "transposon silencing abnormal" NARROW [] is_a: WBPhenotype:0002063 ! maintenance of gene silencing variant [Term] id: WBPhenotype:0000746 name: cell division variant def: "Any variation that alters the physical partitioning and separation of a cell into daughter cells compared to control." [GO:0051301, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell division abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000747 name: pharyngeal contraction defective def: "Any defects in the muscle contractions that control feeding. Contractions are necessary for bacterial uptake from the surrounding environment." [WB:WBPaper00001696] is_a: WBPhenotype:0000980 ! pharyngeal contraction variant [Term] id: WBPhenotype:0000748 name: asymmetric cell division defective early emb def: "Symmetric (PAR-like) divisions or excessive posterior displacement (zyg-8 like phenotypes)." [WB:cab, WB:cgc7141] synonym: "asymmetric cell division abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001100 ! early embryonic lethal is_a: WBPhenotype:0001235 ! cell division polarity variant [Term] id: WBPhenotype:0000749 name: embryonic development variant def: "Variations in the progression of an embryo over time, from zygote formation to hatching compared to control." [GO:0009790, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "developmental defects detected in embryos" RELATED [] synonym: "embryonic development abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism development variant [Term] id: WBPhenotype:0000750 name: larval development variant def: "Variations in the progression of a larva over time, from its formation to the mature structure compared to control. The larva is the early, immature form of an animal between hatching and adulthood." [GO:0002164, WB:WBPerson2021] synonym: "larval development abnormal" NARROW [] is_a: WBPhenotype:0000049 ! postembryonic development variant [Term] id: WBPhenotype:0000751 name: L1 larval development variant def: "Variations in the progression of a newly hatched animal through the first larval molt compared to control." [WB:WBPerson2021] synonym: "L1 larval development abnormal" NARROW [] is_a: WBPhenotype:0000750 ! larval development variant [Term] id: WBPhenotype:0000752 name: L2 larval development variant def: "Variations in the progression of the second larval stage compared to control." [WB:WBPerson557] synonym: "L2 larval development abnormal" NARROW [] is_a: WBPhenotype:0000750 ! larval development variant [Term] id: WBPhenotype:0000753 name: L3 larval development variant def: "Variations in the progression of the third larval stage compared to control." [WB:WBPerson557] synonym: "L3 larval development abnormal" NARROW [] is_a: WBPhenotype:0000750 ! larval development variant [Term] id: WBPhenotype:0000754 name: L4 larval development variant def: "Variations in the progression of the fourth larval stage compared to control." [WB:WBPerson557] synonym: "L4 larval development abnormal" NARROW [] is_a: WBPhenotype:0000750 ! larval development variant [Term] id: WBPhenotype:0000755 name: L1 L2 molt defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L1 to L2 transition." [GO:0018996] synonym: "L1 L2 molt abnormal" NARROW [] synonym: "L1 molt" RELATED [] is_a: WBPhenotype:0000638 ! molt defect [Term] id: WBPhenotype:0000756 name: L2 L3 molt defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L2 to L3 transition." [GO:0018996] synonym: "L2 L3 molt abnormal" NARROW [] synonym: "L2 molt" RELATED [] is_a: WBPhenotype:0000638 ! molt defect [Term] id: WBPhenotype:0000757 name: L3 L4 molt defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L3 to L4 transition." [GO:0018996] synonym: "L3 L4 molt abnormal" NARROW [] synonym: "L3 molt" RELATED [] is_a: WBPhenotype:0000638 ! molt defect [Term] id: WBPhenotype:0000758 name: L4 adult molt defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L4 to adult transition." [GO:0018996] synonym: "L4 adult molt abnormal" NARROW [] synonym: "L4 molt" RELATED [] is_a: WBPhenotype:0000638 ! molt defect [Term] id: WBPhenotype:0000759 name: spindle defective early emb def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubules and associated molecules that form between opposite poles of a eukaryotic cell during a cell cycle." [GO:0007051, WB:WBPerson2021] comment: Possible XP. synonym: "Emb" BROAD [] synonym: "Spd" BROAD [] synonym: "spindle abnormal" NARROW [] is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0000760 name: spindle orientation defective early emb def: "The alignment of the spindle relative to other cellular structures in the cells of an embryo varies from that observed in control animals." [WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "spindle orientation abnormal" NARROW [] synonym: "Spn" BROAD [] is_a: WBPhenotype:0000761 ! spindle position orientation defective early emb is_a: WBPhenotype:0001681 ! spindle orientation variant [Term] id: WBPhenotype:0000761 name: spindle position orientation defective early emb def: "Early embryos exhibit defects in the placement or the alignment of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Spi" RELATED [] synonym: "spindle position orientation abnormal" NARROW [] synonym: "Spo" BROAD [] is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb [Term] id: WBPhenotype:0000762 name: spindle position defective early emb def: "Early embryos exhibit defects in the placement of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [GO:0051653, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "Abs" BROAD [] synonym: "Emb" BROAD [] synonym: "spindle position abnormal" NARROW [] is_a: WBPhenotype:0000761 ! spindle position orientation defective early emb [Term] id: WBPhenotype:0000763 name: embryonic cell physiology variant def: "Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for an embryonic cell to carry out its normal function and activities or be able to perceive and respond to stimuli." [GO:0009987, WB:WBPerson557] subset: phenotype_slim_wb synonym: "embryonic cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000764 name: embryonic cell organization biogenesis variant def: "Variations in the processes that are carried out at in the embryo which results in its formation or the arrangement of constituent parts, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "embryonic cell organization biogenesis abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic development variant is_a: WBPhenotype:0000763 ! embryonic cell physiology variant is_a: WBPhenotype:0010002 ! cell organization biogenesis variant [Term] id: WBPhenotype:0000765 name: spindle elongation integrity defective early emb def: "The embryos exhibit defects in the cell cycle process whereby the distance is lengthened between poles of the spindle." [GO:0051231, WB:cab, WB:cgc7141, WB:WBPerson2021] comment: Possible XP. synonym: "Emb" BROAD [] synonym: "spindle elongation integrity abnormal" NARROW [] is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb [Term] id: WBPhenotype:0000766 name: centrosome pair and associated pronuclear rotation variant def: "Any variation in the rotation of the centrosome-pronuclear complex after its migration toward the center of the embryo, compared to control." [WB:WBPaper00004895, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "centrosome pair and associated pronuclear rotation abnormal" NARROW [] synonym: "Rot" BROAD [] is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant [Term] id: WBPhenotype:0000767 name: integrity of membranous organelles defective early emb def: "Sparse or enlarged yolk granules." [WB:cab, WB:WBPaper00025054] synonym: "Emb" BROAD [] synonym: "integrity of membranous organelles abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0000768 name: cytoplasmic structure defective early emb def: "Areas devoid of yolk granules throughout the embryo." [WB:cab, WB:cgc7141] synonym: "Aberrant Cytoplasmic Structure" RELATED [] synonym: "cellular structure disorganized" RELATED [] synonym: "cytoplasmic structure abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001081 ! cytoplasmic morphology defective early emb [Term] id: WBPhenotype:0000769 name: cytoplasmic appearance defective early emb def: "Embryos exhibit defects in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control embryos." [WB:WBPerson2021, WB:WBPerson557] synonym: "cytoplasmic appearance abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001100 ! early embryonic lethal is_a: WBPhenotype:0001427 ! cytoplasmic appearance variant [Term] id: WBPhenotype:0000770 name: embryonic cell morphology variant def: "Animals exhibit variations in the appearance of embryonic cells compared to control." [WB:cab] subset: phenotype_slim_wb synonym: "embryonic cell morphology abnormal" NARROW [] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000771 name: centrosome attachment defective early emb def: "Centrosomes detach from the male pronucleus." [WB:cab, WB:cgc7141] synonym: "centrosome attachment abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000770 ! embryonic cell morphology variant is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0000772 name: sister chromatid segregation defective early emb def: "Daughter nuclei are deformed and stay close to central cortex, cytokinesis defects." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] synonym: "sister chromatid segregation abnormal" NARROW [] is_a: WBPhenotype:0000773 ! chromosome segregation variant is_a: WBPhenotype:0001078 ! cytokinesis defective early emb [Term] id: WBPhenotype:0000773 name: chromosome segregation variant def: "Any variation in the processes that regulate the apportionment of chromosomes to each of two daughter cells compared to control." [GO:0007059, WB:kmva, WB:WBPerson2021, WB:WBPerson557] synonym: "chromosome segregation abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0000774 name: gametogenesis variant def: "Any variation in the processes that govern the generation and maintenance of gametes compared to control." [GO:0007276, WB:WBPerson2021] synonym: "gametogenesis abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000775 name: meiosis variant def: "Variations in the specialized nuclear and cytoplasmic divisions of a single diploid cell, whose specific outcome is the formation of four haploid daughter cells compared to control. Meiosis occurs during the formation of gametes." [GO:0007126, WB:WBPerson2021] synonym: "germ cell meiosis abnormal" RELATED [] synonym: "germ cell meiosis variant" RELATED [] synonym: "Mei" RELATED [] synonym: "meiosis abnormal" NARROW [] is_a: WBPhenotype:0000812 ! germ cell development variant [Term] id: WBPhenotype:0000776 name: passage through meiosis defective early emb def: "Male and female PNs not visible; embryo often fills egg shell completely." [WB:cab, WB:cgc71441] synonym: "Emb" BROAD [] synonym: "passage through meiosis abnormal" NARROW [] is_a: WBPhenotype:0000775 ! meiosis variant is_a: WBPhenotype:0001041 ! meiosis defective early emb [Term] id: WBPhenotype:0000777 name: polar body extrusion defective early emb def: "Unextruded or resorbed polar body(ies) leading to an extra PNs in P0 and/or extra karyomeres in AB/P1." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] synonym: "polar body extrusion abnormal" NARROW [] is_a: WBPhenotype:0000775 ! meiosis variant is_a: WBPhenotype:0001147 ! polar body defective early emb [Term] id: WBPhenotype:0000778 name: feeding inefficient def: "Animals are unable to ingest nutrients at a rate similar to control animals." [WB:WBPaper00032342, WB:WBPerson712] is_a: WBPhenotype:0000659 ! feeding behavior variant [Term] id: WBPhenotype:0000779 name: late embryonic arrest def: "Cessation of development during the final stages of embryogenesis. In C. elegans, this stage normally occurs 620-800 min after the first cleavage at 20C and is the stage after elongation." [WB:WBPerson101] is_a: WBPhenotype:0000867 ! embryonic arrest [Term] id: WBPhenotype:0000780 name: shaker def: "Animals rotate back and forth around their longitudinal axes." [WB:cab, WB:cgc914] is_a: WBPhenotype:0001701 ! spastic locomotion [Term] id: WBPhenotype:0000781 name: body wall muscle thin filament variant def: "Any variation in the extremely thin elongated cytoplasmic filament, usually composed principally of actin protein to form a myofilament lattice, as in muscle cells compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "thin filament abnormal" NARROW [] synonym: "thin filament variant" RELATED [] is_a: WBPhenotype:0001889 ! body wall muscle sarcomere morphology variant [Term] id: WBPhenotype:0000782 name: body wall muscle thick filament variant def: "Animals exhibit variations in the form, structure or composition of a robust elongated cytoplasmic filament composed principally of myosin protein compared to control animals. In C. elegans, thick filaments also contain paramyosin and twitchin (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "thick filament abnormal" NARROW [] synonym: "thick filament variant" RELATED [] is_a: WBPhenotype:0001889 ! body wall muscle sarcomere morphology variant [Term] id: WBPhenotype:0000783 name: M line absent def: "Animals lack the planar structure within the muscle sarcomere which lies midway within the thick filament (A) band, attaching to the plasma membrane at its base and running up towards the inward surface of the myofilament lattice, compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001891 ! M line variant [Term] id: WBPhenotype:0000784 name: male fertility variant def: "Males exhibit variations in the time of onset or duration of the fertile period owing to differences in sperm competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "male fertility abnormal" NARROW [] is_a: WBPhenotype:0000145 ! fertility variant [Term] id: WBPhenotype:0000785 name: body part pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular body part compared to control animals." [WB:WBPerson557] synonym: "body part pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000278 ! body region pigmentation variant [Term] id: WBPhenotype:0000786 name: body axis pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency along a particular body axis compared to control." [WB:WBPerson557] synonym: "body axis pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000278 ! body region pigmentation variant [Term] id: WBPhenotype:0000787 name: posterior pale def: "Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the posterior body axis compared to control." [WB:WBPerson557] is_a: WBPhenotype:0000984 ! posterior pigmentation variant is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000788 name: anterior pale def: "Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the anterior body axis compared to control." [WB:WBPerson557] is_a: WBPhenotype:0000971 ! anterior pigmentation variant is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000789 name: fluoxetine hypersensitive def: "Animals respond to fluoxetine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0000790 name: fluoxetine resistant def: "Animals fail to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0000791 name: nose resistant to fluoxetine def: "The nose of an animal fails to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000790 ! fluoxetine resistant [Term] id: WBPhenotype:0000792 name: anterior body morphology variant def: "Animals exhibit variations in the form, structure or composition of the anatomy contained in the anterior region, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior body morphology abnormal" NARROW [] synonym: "anterior region morphology abnormal" NARROW [] synonym: "anterior region morphology variant" EXACT [] is_a: WBPhenotype:0000072 ! body morphology variant is_a: WBPhenotype:0000581 ! body axis morphology variant [Term] id: WBPhenotype:0000793 name: posterior body morphology variant def: "Animals exhibit variations in the form, structure or composition of the anatomy contained in the posterior region, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior body morphology abnormal" NARROW [] synonym: "posterior region morphology abnormal" NARROW [] synonym: "posterior region morphology variant" EXACT [] is_a: WBPhenotype:0000072 ! body morphology variant is_a: WBPhenotype:0000581 ! body axis morphology variant [Term] id: WBPhenotype:0000794 name: posterior body thin def: "The posterior part of the worm exhibits a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000793 ! posterior body morphology variant [Term] id: WBPhenotype:0000795 name: body axis behavior variant def: "Variations in the specific actions or reactions of one of the longitudinal axes of the extended body of the worm in response to external or internal stimuli compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "body axis behavior abnormal" NARROW [] is_a: WBPhenotype:0000522 ! organism region behavior variant [Term] id: WBPhenotype:0000796 name: posterior body uncoordinated def: "The movement of the posterior part of the worm is not coordinated with the rest of the body." [WB:cab] is_a: WBPhenotype:0000797 ! posterior body behavior variant [Term] id: WBPhenotype:0000797 name: posterior body behavior variant def: "Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the tail of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior body behavior abnormal" NARROW [] is_a: WBPhenotype:0000795 ! body axis behavior variant [Term] id: WBPhenotype:0000798 name: anterior body behavior variant def: "Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the head of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior body behavior abnormal" NARROW [] is_a: WBPhenotype:0000795 ! body axis behavior variant [Term] id: WBPhenotype:0000799 name: anterior region development variant def: "Variations in the progression of an animal's anatomy contained in the anterior region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior region development abnormal" NARROW [] is_a: WBPhenotype:0000578 ! body axis development variant [Term] id: WBPhenotype:0000800 name: posterior region development variant def: "Variations in the progression of an animal's anatomy contained in the posterior region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior region development abnormal" NARROW [] is_a: WBPhenotype:0000578 ! body axis development variant [Term] id: WBPhenotype:0000801 name: ventral region development variant def: "Variations in the progression of an animal's anatomy contained in the ventral region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "ventral region development abnormal" NARROW [] is_a: WBPhenotype:0000578 ! body axis development variant [Term] id: WBPhenotype:0000802 name: dorsal region development variant def: "Variations in the progression of an animal's anatomy contained in the dorsal region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dorsal region development abnormal" NARROW [] is_a: WBPhenotype:0000578 ! body axis development variant [Term] id: WBPhenotype:0000803 name: head development variant def: "Variations in the progression of the anterior end of the animal over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "head development abnormal" NARROW [] is_a: WBPhenotype:0000579 ! organism segment development variant [Term] id: WBPhenotype:0000804 name: body development variant def: "Variations in the progression of the overall structure or appearance of the animal over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body development abnormal" NARROW [] is_a: WBPhenotype:0000579 ! organism segment development variant [Term] id: WBPhenotype:0000805 name: tail development variant def: "Any variation in the process whose specific outcome is the progression of the tail over time, from its formation to the mature structure, compared to control. The tail includes the posterior region that spans from the rectum to the end." [WB:WBPerson2021] synonym: "tail development abnormal" NARROW [] is_a: WBPhenotype:0000579 ! organism segment development variant [Term] id: WBPhenotype:0000806 name: hermaphrodite fertility variant def: "Hermaphrodites exhibit variations in the time of onset or duration of the fertile period, or variations in the production of viable offspring, including number and state of fertilized eggs laid, compared to controls." [WB:WBPerson712] synonym: "hermaphrodite fertility abnormal" NARROW [] is_a: WBPhenotype:0000145 ! fertility variant [Term] id: WBPhenotype:0000807 name: G lineages variant def: "The descendants of the G1 or G2 exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "G lineages abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000808 name: K lineage variant def: "The descendants of the K precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "K lineage abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000809 name: male specific lineage variant def: "The descendants of a male specific precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male specific lineage abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000810 name: blast cell development variant def: "Any variation in the progression of a blast cell (precursor cell) over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "blast cell development abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000811 name: epithelial cell development variant def: "Any variation in the progression of an epithelial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "epithelial cell development abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000812 name: germ cell development variant def: "Variations in the progression of the immature germ cell over time, from its formation from precursors to the mature structure (gamete) compared to control." [GO:0007281, WB:WBPerson2021] synonym: "germ cell development abnormal" NARROW [] synonym: "germline development abnormal" RELATED [] is_a: WBPhenotype:0000774 ! gametogenesis variant [Term] id: WBPhenotype:0000813 name: gland cell development variant def: "Any variation in the progression of a gland cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "gland cell development abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000814 name: marginal cell development variant def: "Any variation in the progression of a marginal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A marginal cell is a pharyngeal cell that connects the basement membrane to the apices of the triangle-shaped pharyngeal lumen." [WB:WBPerson2021] synonym: "marginal cell development abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000815 name: muscle cell development variant def: "Any variation in the progression of a muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "muscle cell development abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000816 name: neuron development variant def: "Variations in the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [GO:0048666, WB:WBPerson2021] synonym: "neuron development abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000817 name: uterine vulval cell development variant def: "Variations in the progression of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) over time from an initial condition to a later condition compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "uterine vulval cell development abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0000818 name: adult behavior variant def: "Activity characteristic of an adult worm is altered compared to control." [WB:cab] synonym: "adult behavior abnormal" NARROW [] is_a: WBPhenotype:0000819 ! postembryonic behavior variant [Term] id: WBPhenotype:0000819 name: postembryonic behavior variant def: "Behavior characteristic of postembryonic stage(s) is altered compared to control." [WB:cab] synonym: "postembryonic behavior abnormal" NARROW [] is_a: WBPhenotype:0001000 ! developmental behavior variant [Term] id: WBPhenotype:0000820 name: embryonic behavior variant def: "Activity characteristic of an embryo is altered compared to control." [WB:cab] synonym: "embryonic behavior abnormal" NARROW [] is_a: WBPhenotype:0001000 ! developmental behavior variant [Term] id: WBPhenotype:0000821 name: sexually dimorphic behavior variant def: "Animals exhibit variations in sex-specific behaviors compared to control." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "sexually dimorphic behavior abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0000822 name: sex determination variant def: "Any variation in the processes that govern the sexually dimorphic development of germline or somatic tissue compared to control." [WB:kmva] synonym: "sex determination abnormal" NARROW [] synonym: "sex specific development abnormal" RELATED [] is_a: WBPhenotype:0000930 ! sexually dimorphic development variant [Term] id: WBPhenotype:0000823 name: germline proliferation variant def: "Nuclear divisions in the germ line are either expanded are reduced compared to control." [WB:cab] synonym: "germ cell proliferation abnormal" RELATED [] synonym: "germ line proliferation abnormal" EXACT [] synonym: "germline proliferation abnormal" NARROW [] synonym: "Glp" BROAD [] is_a: WBPhenotype:0000812 ! germ cell development variant [Term] id: WBPhenotype:0000824 name: embryonic cell lineage variant def: "The descendants of an embryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "embryonic cell lineage abnormal" NARROW [] is_a: WBPhenotype:0000093 ! lineage variant [Term] id: WBPhenotype:0000825 name: postembryonic cell lineage variant def: "The descendants of a postembryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "postembryonic cell lineage abnormal" NARROW [] is_a: WBPhenotype:0000093 ! lineage variant [Term] id: WBPhenotype:0000826 name: H lineages variant def: "The descendants of H1 or H2 cells exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "H lineages abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000827 name: V lineages variant def: "The descendants of any of the V precursor cells (V1-V6) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "V lineages abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000828 name: T lineages variant def: "The descendants of TL or TR cells exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "T lineages abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000829 name: Q lineage variant def: "The descendants of Q L or QR cells exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Q lineage abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000830 name: B lineage variant def: "The descendants of the B cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "B lineage abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male specific lineage variant [Term] id: WBPhenotype:0000831 name: Y lineage variant def: "The descendants of the Y cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Y lineage abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male specific lineage variant [Term] id: WBPhenotype:0000832 name: C lineage variant def: "The descendants of the C blastomere exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPaper00001584, WB:WBPerson2021] synonym: "C lineage abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic cell lineage variant [Term] id: WBPhenotype:0000833 name: U lineage variant def: "The descendants of the U cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "U lineage abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male specific lineage variant [Term] id: WBPhenotype:0000834 name: E lineage variant def: "The descendants of the E blastomere exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPaper00002870, WB:WBPerson2021] synonym: "E lineage abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic cell lineage variant [Term] id: WBPhenotype:0000835 name: F lineage variant def: "The descendants of the F cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "F lineage abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male specific lineage variant [Term] id: WBPhenotype:0000836 name: gonadal lineage variant def: "The descendants of a gonadal precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "gonadal lineage abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000837 name: hermaphrodite gonadal lineage variant def: "The descendants of a gonadal precursor cell exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "hermaphrodite gonadal lineage abnormal" NARROW [] is_a: WBPhenotype:0000836 ! gonadal lineage variant [Term] id: WBPhenotype:0000838 name: male gonadal lineage variant def: "The descendants of a gonadal precursor cell exhibit altered developmental programs in the male compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male gonadal lineage abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male specific lineage variant is_a: WBPhenotype:0000836 ! gonadal lineage variant [Term] id: WBPhenotype:0000839 name: Z1 hermaphrodite lineage variant def: "Z1 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Z1 hermaphrodite lineage abnormal" NARROW [] is_a: WBPhenotype:0000837 ! hermaphrodite gonadal lineage variant [Term] id: WBPhenotype:0000840 name: Z4 hermaphrodite lineage variant def: "Z4 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Z4 hermaphrodite lineage abnormal" NARROW [] is_a: WBPhenotype:0000837 ! hermaphrodite gonadal lineage variant [Term] id: WBPhenotype:0000841 name: Z1 male lineage variant def: "Z1 descendents exhibit altered developmental programs in the male compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Z1 male lineage abnormal" NARROW [] is_a: WBPhenotype:0000838 ! male gonadal lineage variant [Term] id: WBPhenotype:0000842 name: Z4 male lineage variant def: "Z4 descendants exhibit altered developmental programs in the male compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Z4 male lineage abnormal" NARROW [] is_a: WBPhenotype:0000838 ! male gonadal lineage variant [Term] id: WBPhenotype:0000843 name: male mating efficiency reduced def: "The number of cross progeny sired by males is reduced compared to control." [WB:WBPaper00000179, WB:WBPaper00000608, WB:WBPerson557] is_a: WBPhenotype:0000648 ! male mating variant [Term] id: WBPhenotype:0000844 name: serotonin induced pumping variant def: "Pharyngeal pumping is not influenced by serotonin treatment in the same manner as control animals." [WB:WBPerson2021] synonym: "serotonin induced pumping abnormal" NARROW [] is_a: WBPhenotype:0000024 ! serotonin resistant is_a: WBPhenotype:0001232 ! serotonin response variant is_a: WBPhenotype:0001285 ! induced pharyngeal pumping variant [Term] id: WBPhenotype:0000845 name: levamisole response variant def: "Animals exhibit variations in the response to the addition of levamisole compared to that observed in control animals. Levamisole is a cholinergic agonist." [WB:WBPerson557] synonym: "levamisole response abnormal" NARROW [] synonym: "tetramisole response abnormal" RELATED [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0000846 name: presynaptic region physiology variant def: "Animals exhibit variations in any physical or chemical process in the region of the vesicle-filled varicosities of the synapse compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "presynaptic region physiology abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic transmission variant [Term] id: WBPhenotype:0000847 name: presynaptic component localization variant def: "Animals display variations in the distribution of the constituents that make up the synaptic machinery such as those required for priming, docking or fusion of vesicles at the active zone, compared to that observed in control animals." [WB:WBPaper00027305, WB:WBPerson712] synonym: "presynaptic component localization abnormal" NARROW [] synonym: "synaptic component localization abnormal" RELATED [] synonym: "synaptic machinery localization abnormal" RELATED [] is_a: WBPhenotype:0001321 ! presynaptic region morphology variant [Term] id: WBPhenotype:0000848 name: developmental delay def: "The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000438 ! retarded heterochronic variations [Term] id: WBPhenotype:0000849 name: amphid physiology variant def: "Animals exhibit variations in any physical or chemical process required for an amphid to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557] synonym: "amphid physiology abnormal" NARROW [] is_a: WBPhenotype:0000652 ! sensory system variant [Term] id: WBPhenotype:0000850 name: touch resistant anterior body def: "Animal does not respond to stroking in the anterior body region with a hair or similar fiber compared to control. In C. elegans, the anterior region is defined as the body region that lies between the posterior bulb of the pharynx and the vulva." [WB:WBPaper00000502, WB:WBPaper00001705, WB:WBPerson557] synonym: "touch insensitive anterior body" RELATED [] is_a: WBPhenotype:0000456 ! touch resistant [Term] id: WBPhenotype:0000851 name: ciliated neuron physiology variant def: "Animals exhibit variations in any physical or chemical process required for the ciliated neuron to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "ciliated neuron physiology abnormal" NARROW [] is_a: WBPhenotype:0000991 ! neuron physiology variant [Term] id: WBPhenotype:0000852 name: coelomocyte development variant def: "Variations in the progression of a free-floating spherical cell lying in the pseudocoelomic cavity of animals that can endocytose many compounds, possibly for immune surveillance, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "coelomocyte development abnormal" NARROW [] is_a: WBPhenotype:0000618 ! coelomic system development variant [Term] id: WBPhenotype:0000853 name: intraflagellar transport variant def: "Variations in the bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum, compared to control." [GO:0042073, WB:WBPerson2021] synonym: "IFT abnormal" RELATED [] synonym: "intraflagellar transport abnormal" NARROW [] is_a: WBPhenotype:0000851 ! ciliated neuron physiology variant [Term] id: WBPhenotype:0000854 name: intraflagellar transport defective def: "Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is disrupted." [WB:WBPerson2021] synonym: "ift defective" RELATED [] is_a: WBPhenotype:0000853 ! intraflagellar transport variant [Term] id: WBPhenotype:0000855 name: pseudocoelom development variant def: "Variations in the progression of the fluid-filled space which separates the bodywall from internal organs over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "pseudocoelom development abnormal" NARROW [] is_a: WBPhenotype:0000200 ! pericellular component development variant [Term] id: WBPhenotype:0000856 name: excretory gland cell development variant def: "Any variation in the progression of a gland cell of the secretory-excretory system over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "excretory gland cell development abnormal" NARROW [] is_a: WBPhenotype:0000620 ! excretory secretory system development variant is_a: WBPhenotype:0000813 ! gland cell development variant [Term] id: WBPhenotype:0000857 name: excretory cell development variant def: "Variations in the progression of a protokidney cell with an internal lumen that is suggested to collect and secrete salt solutions outward via the excretory sinus, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory canal cell development abnormal" RELATED [] synonym: "excretory cell development abnormal" NARROW [] is_a: WBPhenotype:0000621 ! excretory system development variant [Term] id: WBPhenotype:0000858 name: excretory duct cell development variant def: "Variations in the progression of an interfacial epithelial cell which forms a lumen to receive the outflow of the excretory gland and excretory canal cells, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory duct cell development abnormal" NARROW [] is_a: WBPhenotype:0000621 ! excretory system development variant [Term] id: WBPhenotype:0000859 name: excretory socket cell development variant def: "Variations in the progression of an interfacial epithelial cell which links excretory duct to hypodermis, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory pore cell development abnormal" RELATED [] synonym: "excretory socket cell development abnormal" NARROW [] is_a: WBPhenotype:0000621 ! excretory system development variant [Term] id: WBPhenotype:0000860 name: nonstriated muscle development variant def: "Variations in the progression of muscle cells that lack transverse striations in its constituent fibers and are almost always involuntary, over time from an initial condition to a later condition compared to control animals." [GO:0051145, WB:WBPerson2021, WB:WBPerson557] synonym: "nonstriated muscle development abnormal" NARROW [] is_a: WBPhenotype:0000622 ! muscle system development variant [Term] id: WBPhenotype:0000861 name: body wall muscle development variant def: "Any variation in the progression of the principal muscle cell type whose contractile activity generates body motion in the nematode over time compared to control. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the bodywall (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "body wall muscle development abnormal" NARROW [] synonym: "somatic muscle development abnormal" RELATED [] synonym: "striated muscle development abnormal" RELATED [] is_a: WBPhenotype:0000921 ! striated muscle development variant [Term] id: WBPhenotype:0000862 name: bloated def: "Worms appears turgid or swollen as a result of an excess number of eggs being retained in the uterus." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000545 ! egg retention [Term] id: WBPhenotype:0000863 name: male fertility reduced def: "Males exhibit a reduction in the production of new individuals owing to defects in sperm competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000784 ! male fertility variant [Term] id: WBPhenotype:0000864 name: early elongation arrest def: "Cessation of development during the initial period of elongation. In C. elegans, this period refers to the conversion of the bean-shaped embryo into the two-fold- shaped embryo." [WB:WBPaper00027244] is_a: WBPhenotype:0000867 ! embryonic arrest [Term] id: WBPhenotype:0000865 name: amphid sheath cell physiology variant def: "Animals exhibit variations in any physical or chemical process required for a amphid sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557] synonym: "amphid sheath cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000849 ! amphid physiology variant [Term] id: WBPhenotype:0000866 name: germ cell arrest def: "Germ cells fail to undergo meiotic differentiation to form mature gametes." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000823 ! germline proliferation variant [Term] id: WBPhenotype:0000867 name: embryonic arrest def: "Cessation of development during any stage occurring after fertilization and until hatching compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0000868 name: paralyzed body def: "All parts of the animal are immobilized except for the head." [WB:cab] is_a: WBPhenotype:0000644 ! paralyzed [Term] id: WBPhenotype:0000869 name: mitochondria morphology variant muscle synonym: "mitochondria morphology abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000870 name: mitochondria morphology variant epithelial synonym: "mitochondria morphology abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000871 name: connected mitochondria epithelial is_obsolete: true [Term] id: WBPhenotype:0000872 name: connected mitochodria muscle is_obsolete: true [Term] id: WBPhenotype:0000873 name: G1 checkpoint variant def: "Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G1 phase of the mitotic cell cycle just before entry into S phase, compared to control cells." [GO:0007089, WB:WBPerson557, WB:WBPerson712] synonym: "G1 checkpoint abnormal" NARROW [] is_a: WBPhenotype:0000741 ! DNA damage checkpoint variant [Term] id: WBPhenotype:0000874 name: G2 checkpoint variant def: "Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G2 phase of the mitotic cell cycle just before entry into M phase, nuclear division, compared to control cells." [GO:0000075, WB:WBPerson557, WB:WBPerson712] synonym: "G2 checkpoint abnormal" NARROW [] is_a: WBPhenotype:0000741 ! DNA damage checkpoint variant [Term] id: WBPhenotype:0000875 name: S phase checkpoint variant def: "Mitotic cells exhibit variations during the passage through a cell cycle control point late in the S phase of the mitotic cell cycle, which ensures DNA replication is complete, compared to control cells." [GO:0033314, WB:WBPerson712] synonym: "S phase checkpoint abnormal" NARROW [] is_a: WBPhenotype:0000741 ! DNA damage checkpoint variant [Term] id: WBPhenotype:0000876 name: organism osmotic stress response variant def: "Animals exhibit variations in their response to osmotic stress compared to that observed in control animals." [WB:WBPerson557] synonym: "organism osmotic stress response abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0000877 name: amphid sheath cell development variant def: "Any variation in the progression of a sheath cell of the amphid sensillum over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "amphid sheath cell development abnormal" NARROW [] is_a: WBPhenotype:0000950 ! neuronal sheath cell development variant [Term] id: WBPhenotype:0000878 name: chemosensory neuron development variant def: "Any variation in the progression of a chemosensory neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "chemosensory neuron development abnormal" NARROW [] is_a: WBPhenotype:0000816 ! neuron development variant [Term] id: WBPhenotype:0000879 name: telomere length regulation variant def: "Animals exhibit variations in the processes that are required to maintain the length of telomeric DNA from generation to generation compared to control." [GO:0032204, WB:WBPaper00031585, WB:WBPerson712] synonym: "telomere length regulation abnormal" NARROW [] is_a: WBPhenotype:0001673 ! telomere homeostasis variant [Term] id: WBPhenotype:0000880 name: axon development variant def: "Any variation in the processes that influence the generation of neuronal extensions, that carry efferent (outgoing) action potentials from the cell body towards target cells compared to control." [GO:0007409, WB:WBPerson2021] synonym: "axon development abnormal" NARROW [] synonym: "axonogenesis abnormal" RELATED [] is_a: WBPhenotype:0000944 ! neurite development variant [Term] id: WBPhenotype:0000881 name: cilia mislocalized def: "Animals exhibit variations in the placement of the microtuble-based dendritic projections in relation to the sensillum neuron, from that observed in control animals." [WB:WBPerson712] is_a: WBPhenotype:0001526 ! ciliated neuron morphology variant [Term] id: WBPhenotype:0000882 name: dendrite development variant def: "Any variation in the processes that influence the generation of neuronal extensions, that carry afferent (incoming) action potentials towards the cell body compared to control." [GO:0016358, WB:WBPerson2021] synonym: "dendrite development abnormal" NARROW [] is_a: WBPhenotype:0000944 ! neurite development variant [Term] id: WBPhenotype:0000883 name: nerve ring development variant def: "Variations in the progression of the major zone of overlapping axons in the head, which encircles the isthmus of the pharynx to form a tightly packed ring-like structure on the outside of the pharynx, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "nerve ring development abnormal" NARROW [] is_a: WBPhenotype:0000945 ! neuropil development variant [Term] id: WBPhenotype:0000884 name: AWB morphology variant def: "Animals exhibit variations in the structure or organization of either of a set of two ciliated wing neurons, AWBL or AWBR, of the amphid sensilla, compared to that observed in control animals." [WB:WBPaper00000938, WB:WBPerson712] comment: WBbt:0005671. synonym: "AWB morphology abnormal" NARROW [] is_a: WBPhenotype:0000256 ! amphid morphology variant [Term] id: WBPhenotype:0000885 name: engulfment variant def: "Any variation in the removal of a cell corpse, by a neighboring cell or a phagocyte compared to control." [GO:0043652, WB:WBPerson2021] synonym: "engulfment abnormal" NARROW [] synonym: "phagocytosis abnormal" RELATED [] is_a: WBPhenotype:0000730 ! apoptosis variant [Term] id: WBPhenotype:0000886 name: Variant def: "Animals exhibit variations compared to a given control." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "Abnormal" NARROW [] [Term] id: WBPhenotype:0000887 name: hermaphrodite behavior variant def: "Animals exhibit variations in hermaphrodite-specific behaviors compared to control." [WB:WBPerson557] synonym: "hermaphrodite behavior abnormal" NARROW [] is_a: WBPhenotype:0000821 ! sexually dimorphic behavior variant [Term] id: WBPhenotype:0000888 name: male behavior variant def: "Animals exhibit variations in male-specific behaviors compared to control." [WB:WBPerson557] synonym: "male behavior abnormal" NARROW [] is_a: WBPhenotype:0000821 ! sexually dimorphic behavior variant [Term] id: WBPhenotype:0000889 name: sexually dimorphic physiology variant def: "Animals exhibit variations in any physical or chemical process required to carry out sex-specific activities or to be able to perceive and respond to sex-specific stimuli compared to control." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "sexually dimorphic physiology abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism physiology variant [Term] id: WBPhenotype:0000890 name: larval pigmentation variant def: "Larva exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals." [WB:WBPerson557] synonym: "larval pigmentation abnormal" NARROW [] is_a: WBPhenotype:0001009 ! developmental pigmentation variant [Term] id: WBPhenotype:0000891 name: clear adult def: "Adult animals appear unusually transparent when compared to control." [WB:WBPerson557] synonym: "Clr" BROAD [] is_a: WBPhenotype:0000346 ! adult pigmentation variant is_a: WBPhenotype:0001010 ! clear [Term] id: WBPhenotype:0000892 name: hermaphrodite germline proliferation variant def: "Nuclear divisions in the germ line of hermaphrodites are either expanded are reduced compared to control." [WB:WBPerson2021] synonym: "hermaphrodite germ cell proliferation abnormal" RELATED [] synonym: "hermaphrodite germ line proliferation abnormal" RELATED [] synonym: "hermaphrodite germline proliferation abnormal" NARROW [] is_a: WBPhenotype:0000823 ! germline proliferation variant [Term] id: WBPhenotype:0000893 name: male germline proliferation variant def: "Nuclear divisions in the germ line of male animals are either expanded are reduced compared to control." [WB:WBPerson2021] synonym: "male germ cell proliferation abnormal" RELATED [] synonym: "male germ line proliferation abnormal" RELATED [] synonym: "male germline proliferation abnormal" NARROW [] is_a: WBPhenotype:0000823 ! germline proliferation variant [Term] id: WBPhenotype:0000894 name: germ cell differentiation variant def: "Variations in the ability of a relatively unspecialized cell to acquire the specialized features of a mature gamete compared to control." [WB:WBPerson2021] synonym: "germ cell differentiation abnormal" NARROW [] is_a: WBPhenotype:0000774 ! gametogenesis variant [Term] id: WBPhenotype:0000897 name: connective tissue development variant def: "Variations in the material made up of fibers forming a framework and support structure for body tissues and organs compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "connective tissue abnormal" NARROW [] is_a: WBPhenotype:0000200 ! pericellular component development variant [Term] id: WBPhenotype:0000898 name: blast cell morphology variant def: "Any variation in the morphological appearance of blast cells compared to control animals." [WB:cab] synonym: "blast cell morphology abnormal" NARROW [] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000899 name: epithelial cell morphology variant def: "Any variation in the morphological appearance of epithelial cells compared to control animals." [WB:WBPerson557] synonym: "epithelial cell morphology abnormal" NARROW [] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000900 name: germ cell morphology variant def: "Any variation in the morphological appearance of germ cells compared to control animals." [WB:cab] synonym: "germ cell morphology abnormal" NARROW [] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000901 name: gland cell morphology variant def: "Any variation in the morphological appearance of gland cells compared to control animals." [WB:cab] synonym: "gland cell morphology abnormal" NARROW [] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000902 name: intestinal cell morphology variant def: "Any variation in the morphological appearance of intestinal cells compared to control animals." [WB:cab] synonym: "intestinal cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000710 ! intestinal morphology variant is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000903 name: marginal cell morphology variant def: "Any variation in the morphological appearance of marginal cells compared to control animals." [WB:cab] synonym: "marginal cell morphology abnormal" NARROW [] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000904 name: muscle cell morphology variant def: "Any variation in the morphological appearance of muscle cells compared to control animals." [WB:cab] synonym: "muscle cell morphology abnormal" NARROW [] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000905 name: neuron morphology variant def: "Animals display variations in the structure or organization of components of the neuronal cell internal to the cell itself or in relation to the cellular environment compared to control. A neuron is a major cell type of nervous tissue specialized for transmission of information in the form of patterns of impulses." [WB:cab, WB:WBPerson712] comment: WBbt:0003679. synonym: "neuron morphology abnormal" NARROW [] is_a: WBPhenotype:0000604 ! nervous system morphology variant is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000906 name: uterine vulval cell morphology variant def: "Animals exhibit variations in the form, structure or composition of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "uterine vulval cell morphology abnormal" NARROW [] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0000907 name: anus morphology variant def: "Any variation in the structural appearance of the caudal opening of the rectum in the tail compared to control animals." [WB:WBPerson557] synonym: "anus morphology abnormal" NARROW [] is_a: WBPhenotype:0000598 ! alimentary system morphology variant [Term] id: WBPhenotype:0000908 name: cloacal morphology variant def: "Any variation in the structural appearance of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) compared to control animals." [WB:WBPerson557] synonym: "cloaca morphology abnormal" EXACT [] synonym: "cloacal morphology abnormal" NARROW [] is_a: WBPhenotype:0000598 ! alimentary system morphology variant is_a: WBPhenotype:0000605 ! reproductive system morphology variant [Term] id: WBPhenotype:0000909 name: pharyngeal intestinal valve morphology variant def: "Any variation in the structure or appearance of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas)." [WB:WBPerson557] synonym: "pharyngeal intestinal valve morphology abnormal" NARROW [] is_a: WBPhenotype:0000598 ! alimentary system morphology variant [Term] id: WBPhenotype:0000910 name: rectal morphology variant def: "Any variation in the morphological appearance of the rectum compared to control animals." [WB:WBPerson557] synonym: "rectal morphology abnormal" NARROW [] is_a: WBPhenotype:0000598 ! alimentary system morphology variant [Term] id: WBPhenotype:0000911 name: coelomocyte morphology variant def: "Any variation in the morphological appearance of coelomocytes compared to control animals." [WB:WBPerson557] synonym: "coelomocyte morphology abnormal" NARROW [] is_a: WBPhenotype:0000599 ! coelomic system morphology variant [Term] id: WBPhenotype:0000912 name: pericellular component morphology variant def: "Any variation in the morphological appearance of pericellular components compared to control animals." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "pericellular component morphology abnormal" NARROW [] is_a: WBPhenotype:0000520 ! morphology variant [Term] id: WBPhenotype:0000913 name: basal lamina morphology variant def: "Any variation in the morphological appearance of the basal lamina compared to control animals." [WB:WBPerson557] synonym: "basal lamina morphology abnormal" NARROW [] is_a: WBPhenotype:0000600 ! epithelial system morphology variant [Term] id: WBPhenotype:0000914 name: excretory gland cell morphology variant def: "Animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory gland cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000601 ! excretory secretory system morphology variant [Term] id: WBPhenotype:0000915 name: pale adult def: "Adults show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000346 ! adult pigmentation variant is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000916 name: excretory cell morphology variant def: "Any variation in the morphological appearance of the excretory cell compared to control animals." [WB:WBPerson557] synonym: "excretory canal cell morphology abnormal" RELATED [] synonym: "excretory cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000601 ! excretory secretory system morphology variant [Term] id: WBPhenotype:0000917 name: excretory duct cell morphology variant def: "Any variation in the morphological appearance of the excretory duct cell compared to control animals." [WB:WBPerson557] synonym: "excretory duct cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000601 ! excretory secretory system morphology variant [Term] id: WBPhenotype:0000918 name: excretory socket cell morphology variant def: "Any variation in the morphological appearance of the excretory socket cell compared to control animals." [WB:WBPerson557] synonym: "excretory socket cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000601 ! excretory secretory system morphology variant [Term] id: WBPhenotype:0000919 name: body wall muscle cell spindle development variant def: "Any variation in the progression of the region of a body wall muscle cell that contains the myofilament lattice (adjacent to the hypodermis) over time, from its initial state to the fully differentiated state compared to control." [WB:WBPaper00000461, WB:WBPerson2021, WB:WBPerson557] synonym: "filament lattice body wall muscle cell development abnormal" RELATED [] synonym: "spindle body wall muscle cell development abnormal" NARROW [] synonym: "spindle body wall muscle cell development variant" RELATED [] is_a: WBPhenotype:0000087 ! body wall cell development variant [Term] id: WBPhenotype:0000920 name: body wall muscle cell development variant synonym: "body wall muscle cell development abnormal" NARROW [] synonym: "muscle belly development abnormal" RELATED [] is_obsolete: true [Term] id: WBPhenotype:0000921 name: striated muscle development variant def: "Variations in the progression of muscle cells that contain fibers that are divided by transverse bands into striations, over time from an initial condition to a later condition compared to control animals." [GO:0055002, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "striated muscle development abnormal" NARROW [] is_a: WBPhenotype:0000622 ! muscle system development variant [Term] id: WBPhenotype:0000922 name: male longitudinal muscle development variant def: "Any variation in the progression of somatic (striated) muscles that run longitudinally in males over time from its initial formation to its mature form compared to control. In C. elegans males have 3 additional sets of sex-specific longitudinal muscles (anterior and posterior outer, anterior and posterior inner, and caudal) that contribute to the body wall musculature (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "male longitudinal muscle development abnormal" NARROW [] is_a: WBPhenotype:0000921 ! striated muscle development variant [Term] id: WBPhenotype:0000923 name: nonstriated muscle morphology variant def: "Any variation in the morphological appearance of the nonstriated muscle compared to control animals." [WB:WBPerson557] synonym: "nonstriated muscle morphology abnormal" NARROW [] is_a: WBPhenotype:0000603 ! muscle system morphology variant [Term] id: WBPhenotype:0000924 name: striated muscle morphology variant def: "Any variation in the morphological appearance of the striated muscle compared to control animals." [WB:WBPerson557] synonym: "striated muscle morphology abnormal" NARROW [] is_a: WBPhenotype:0000603 ! muscle system morphology variant [Term] id: WBPhenotype:0000925 name: sex muscle morphology variant def: "Any variation in the morphological appearance of the sex muscles compared to control animals." [WB:WBPerson557] synonym: "sex muscle morphology abnormal" NARROW [] is_a: WBPhenotype:0000923 ! nonstriated muscle morphology variant [Term] id: WBPhenotype:0000926 name: body wall muscle morphology variant def: "Any variation in the morphological appearance of the body wall muscle compared to control animals." [WB:WBPerson557] synonym: "body wall muscle morphology abnormal" NARROW [] synonym: "Dim" RELATED [] is_a: WBPhenotype:0000924 ! striated muscle morphology variant [Term] id: WBPhenotype:0000927 name: male longitudinal muscle morphology variant def: "Any variation in the morphological appearance of the male longitudinal muscle compared to control animals." [WB:WBPerson557] synonym: "male longitudinal muscle morphology abnormal" NARROW [] is_a: WBPhenotype:0000924 ! striated muscle morphology variant [Term] id: WBPhenotype:0000928 name: male physiology variant def: "Animals exhibit variations in any physical or chemical process required to carry out male-specific activities or to be able to perceive and respond to male-specific stimuli compared to control." [WB:WBPerson557] synonym: "male physiology abnormal" NARROW [] is_a: WBPhenotype:0000889 ! sexually dimorphic physiology variant [Term] id: WBPhenotype:0000929 name: hermaphrodite physiology variant def: "Animals exhibit variations in any physical or chemical process required to carry out hermaphrodite-specific activities or to be able to perceive and respond to hermaphrodite-specific stimuli compared to control." [WB:WBPerson557] synonym: "hermaphrodite physiology abnormal" NARROW [] is_a: WBPhenotype:0000889 ! sexually dimorphic physiology variant [Term] id: WBPhenotype:0000930 name: sexually dimorphic development variant def: "Variations in the progression of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "sexually dimorphic development abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism development variant [Term] id: WBPhenotype:0000931 name: bis phenol A response variant def: "Animals exhibit variations in their response to bis phenol A compared to that observed in control animals." [WB:WBPerson557] synonym: "bis phenol A response abnormal" NARROW [] is_a: WBPhenotype:0000523 ! chemical response variant [Term] id: WBPhenotype:0000932 name: bis phenol A hypersensitive def: "Animals respond to bis phenol A at a lower concentration or a shorter exposure time compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000931 ! bis phenol A response variant [Term] id: WBPhenotype:0000933 name: MS lineage variant def: "The descendants of the MS blastomere exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPaper00002330, WB:WBPerson2021] synonym: "MS lineage abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic cell lineage variant [Term] id: WBPhenotype:0000934 name: developmental morphology variant def: "Animals exhibit variations in the form, structure or composition of any of its parts during a given developmental stage compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "developmental morphology abnormal" NARROW [] is_a: WBPhenotype:0000535 ! organism morphology variant [Term] id: WBPhenotype:0000935 name: D lineage variant def: "The descendants of the D blastomere exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPaper00002572, WB:WBPerson2021] synonym: "D lineage abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic cell lineage variant [Term] id: WBPhenotype:0000936 name: P4 lineage variant def: "The descendants of the P4 blastomere exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "P4 lineage abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic cell lineage variant [Term] id: WBPhenotype:0000937 name: W lineage variant def: "The descendants of the W precursor cell exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "W lineage abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic cell lineage variant [Term] id: WBPhenotype:0000938 name: male V lineages variant def: "The descendants of any of the V precursor cells (V1-V6) in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male V lineages abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male specific lineage variant [Term] id: WBPhenotype:0000939 name: male T lineages variant def: "The descendants of TL or TR cells in male animals exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male T lineages abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male specific lineage variant [Term] id: WBPhenotype:0000940 name: male P lineages variant def: "The descendants of any of the P precursor cells (P1-P12) in male animals exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male P lineages abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male specific lineage variant [Term] id: WBPhenotype:0000941 name: male M lineage variant def: "The descendants of the M precursor cell in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male M lineage abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male specific lineage variant [Term] id: WBPhenotype:0000942 name: accessory cell development variant def: "Any variation in the progression of an accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. An accessory cell supports sensory neurons." [WB:WBPerson2021] synonym: "accessory cell development abnormal" NARROW [] is_a: WBPhenotype:0000623 ! nervous system development variant [Term] id: WBPhenotype:0000943 name: ganglion development variant def: "Any variation in the progression of a cluster of neuron cell bodies (somata) over time from its initial formation to its mature form compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "ganglion development abnormal" NARROW [] is_a: WBPhenotype:0000623 ! nervous system development variant [Term] id: WBPhenotype:0000944 name: neurite development variant def: "Variations in the progression of a neuronal extension (such as axons or dendrites) over time, from its formation to the mature structure compared to control." [GO:0031175, WB:WBPerson2021] synonym: "neurite development abnormal" NARROW [] is_a: WBPhenotype:0000816 ! neuron development variant [Term] id: WBPhenotype:0000945 name: neuropil development variant def: "Any variation in the progression of a dense feltwork of interwoven cytoplasmic processes of nerve cells (dendrites and axons) and support cells, over time from an initial condition to a later condition, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuropil development abnormal" NARROW [] is_a: WBPhenotype:0000623 ! nervous system development variant [Term] id: WBPhenotype:0000946 name: pharyngeal nervous system development variant def: "Variations in the progression of a set of interacting or interdependent entities forming the pharyngeal nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses." [GO:0007420, WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal nervous system development abnormal" NARROW [] is_a: WBPhenotype:0000623 ! nervous system development variant [Term] id: WBPhenotype:0000947 name: connective tissue morphology variant def: "Variations in the form, structure or composition of the material made up of fibers forming a framework and support structure for body tissues and organs compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "connective tissue morphology abnormal" NARROW [] is_a: WBPhenotype:0000912 ! pericellular component morphology variant [Term] id: WBPhenotype:0000948 name: cuticle morphology variant def: "Any variation in the appearance or structure of the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "cuticle morphology abnormal" NARROW [] is_a: WBPhenotype:0000912 ! pericellular component morphology variant [Term] id: WBPhenotype:0000949 name: pseudocoelom morphology variant def: "Any variation in the appearance of the body cavity compared to control. In C. elegans , an aberrancy in the psedocoelom can involve an accumulation of fluids or fluorescent reporters." [WB:WBPerson712] synonym: "pseudocoelom morphology abnormal" NARROW [] is_a: WBPhenotype:0000912 ! pericellular component morphology variant [Term] id: WBPhenotype:0000950 name: neuronal sheath cell development variant def: "Any variation in the progression of a neuronal sheath cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A neuronal sheath cell is a structural cell that forms a specialized environment surrounding the sensory endings of a neuron." [WB:WBPerson2021] synonym: "neuronal sheath cell development abnormal" NARROW [] is_a: WBPhenotype:0000942 ! accessory cell development variant [Term] id: WBPhenotype:0000951 name: socket cell development variant def: "Any variation in the progression of a socket cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "socket cell development abnormal" NARROW [] is_a: WBPhenotype:0000942 ! accessory cell development variant [Term] id: WBPhenotype:0000952 name: anterior ganglion development variant def: "Any variation in the progression of a cluster of neuron somata located close to the nerve ring over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior ganglion development abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion development variant [Term] id: WBPhenotype:0000953 name: dorsal ganglion development variant def: "Any variation in the progression of the ganglion that lies dorsally beside the nerve ring in the head over time from its initial formation to its mature form compared to control. In C. elegans, It contains neuron cell bodies that send their neuronal processes into the ring and longitudinal nerves, but form no local neuropil separate from the nerve ring. The dorsal ganglion is in close contact with the dorsal hypodermal cord (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dorsal ganglion development abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion development variant [Term] id: WBPhenotype:0000954 name: dorsorectal ganglia development variant def: "Any variation in the progression of the ganglion which lies above and behind the rectum in the tail, in close continuity with the anal hypodermal ridge over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dorsorectal ganglia development abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion development variant [Term] id: WBPhenotype:0000955 name: lateral ganglia development variant def: "Any variation in the progression of the left and right lateral ganglia which lie beside the nerve ring in the head over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "lateral ganglia development abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion development variant [Term] id: WBPhenotype:0000956 name: lumbar ganglia development variant def: "Any variation in the progression of the left and right lumbar ganglia which lie behind the pre-anal ganglion in the tail, in lateral positions over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "lumbar ganglia development abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion development variant [Term] id: WBPhenotype:0000957 name: posterior lateral ganglion development variant def: "Any variation in the progression of the neuron somata associated with the post-deirid over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior lateral ganglion development abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion development variant [Term] id: WBPhenotype:0000958 name: preanal ganglion development variant def: "Any variation in the progression of the ganglion which lies at the posterior limit of the ventral nerve cord in the tail over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "preanal ganglion development abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion development variant [Term] id: WBPhenotype:0000959 name: retrovesicular ganglion development variant def: "Any variation in the progression of the ganglion which lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "retrovesicular ganglion development abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion development variant [Term] id: WBPhenotype:0000960 name: ventral ganglion development variant def: "Any variation in the progression of the ganglion which lies ventrally beside the nerve ring in the head, just anterior of the retrovesicular ganglion over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "ventral ganglion development abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion development variant [Term] id: WBPhenotype:0000961 name: pattern of transgene expression variant def: "Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] synonym: "pattern of transgene expression abnormal" NARROW [] is_a: WBPhenotype:0000306 ! transgene expression variant [Term] id: WBPhenotype:0000962 name: level of transgene expression variant def: "Any variation in the measured expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] synonym: "level of transgene expression abnormal" NARROW [] is_a: WBPhenotype:0000306 ! transgene expression variant [Term] id: WBPhenotype:0000963 name: male pigmentation variant def: "Males exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism compared to control animals." [WB:WBPerson557] synonym: "male pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000527 ! organism pigmentation variant [Term] id: WBPhenotype:0000964 name: DMPP resistant def: "Animals fail to respond to the concentration of DMPP that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000681 ! DMPP response variant [Term] id: WBPhenotype:0000965 name: somatic cell death variant def: "Animals exhibit variations in the programmed cell death pathway that is triggered in cells other than germ cells and that is not subject to upstream checkpoint regulation." [WB:WBPaper00032243, WB:WBPerson712] synonym: "somatic cell death abnormal" NARROW [] is_a: WBPhenotype:0001172 ! programmed cell death variant [Term] id: WBPhenotype:0000966 name: germline mortal def: "Progressive decrease in brood size culminating, over generations, in the loss of reproductive ability and thus becoming effectively sterile." [WB:WBPaper00003886, WB:WBPaper00027026, WB:WBPerson712] synonym: "Mrt" BROAD [] is_a: WBPhenotype:0000987 ! germ cell physiology variant [Term] id: WBPhenotype:0000968 name: tail spike variant def: "Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the tail compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000073 ! tail morphology variant [Term] id: WBPhenotype:0000969 name: accessory cell morphology variant def: "Animals exhibit variations in the structure, organization or placement of the cells that support sensory neurons, compared to that observed in control animals. In C. elegans, this category collectively refers to socket cells, sheath cells, and structural cells, or their processes." [WB:WBPerson712] comment: WBbt:0005762. synonym: "accessory cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000604 ! nervous system morphology variant [Term] id: WBPhenotype:0000970 name: embryonic pigmentation variant def: "Embryos exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals ." [WB:WBPerson557] synonym: "embryonic pigmentation abnormal" NARROW [] is_a: WBPhenotype:0001009 ! developmental pigmentation variant [Term] id: WBPhenotype:0000971 name: anterior pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the anterior body axis compared to control." [WB:WBPerson557] synonym: "anterior pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000786 ! body axis pigmentation variant [Term] id: WBPhenotype:0000972 name: neuronal sheath cell morphology variant def: "Animals exhibit variations in the structure or composition of the glia-like support cell of neuronal sensilla that ensheathes the dendrite tips and or processes of neurons, from that observed in control animals. In C. elegans, sheath cells have highly invaginated and vesiculated surfaces, which provide a specialized environment for dendritic structures." [WB:WBPaper00000822, WB:WBPaper00000938, WB:WBPerson712] synonym: "neuronal sheath cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000969 ! accessory cell morphology variant [Term] id: WBPhenotype:0000973 name: homologous recombination increased def: "Animals exhibit an increased frequency of exchange of genetic material between non-sister chromatids of a pair of homologues." [GO:0007131, WB:WBPerson712] is_a: WBPhenotype:0000742 ! DNA recombination variant [Term] id: WBPhenotype:0000974 name: accessory cell physiology variant def: "Animals exhibit variations in any physical or chemical process required by a subset of interfacial cells to carry out its normal function or be able to perceive and respond to stimuli, compared to control. It can refer to socket cells, sheath cells and structural cells or their processes (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "accessory cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000612 ! nervous system physiology variant [Term] id: WBPhenotype:0000975 name: neuronal sheath cell physiology variant def: "Animals exhibit variations in any physical or chemical process required for a neuronal sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557] synonym: "neuronal sheath cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000974 ! accessory cell physiology variant [Term] id: WBPhenotype:0000976 name: ventral cord patterning variant def: "Any variation in the developmental process that results in the creation of defined areas or spaces within the ventral cord to which cells respond and eventually are instructed to differentiate compared to control." [GO:0007389, WB:WBPerson2021, WB:WBPerson557] synonym: "ventral cord patterning abnormal" NARROW [] is_a: WBPhenotype:0000515 ! ventral nerve cord development variant [Term] id: WBPhenotype:0000977 name: somatic gonad morphology variant def: "Animals exhibit variations in the form, structure or composition of the components of the gonad that are separate from the germline proper compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "somatic gonad morphology abnormal" NARROW [] is_a: WBPhenotype:0001355 ! gonad morphology variant [Term] id: WBPhenotype:0000978 name: spermatheca physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the spermatheca to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "spermatheca physiology abnormal" NARROW [] is_a: WBPhenotype:0001197 ! somatic gonad physiology variant [Term] id: WBPhenotype:0000979 name: spermatheca dilation defective def: "Animals exhibit defects in any physical or chemical process involved in the dilation of the distal spermatheca which is required for the oocyte exit from the gonad arm." [WB:WBPaper00003371, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000978 ! spermatheca physiology variant [Term] id: WBPhenotype:0000980 name: pharyngeal contraction variant def: "Any variation in the muscle contractions that control feeding compared to control. Contractions are necessary for bacterial uptake from the surrounding environment." [WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal contraction abnormal" NARROW [] is_a: WBPhenotype:0000634 ! pharyngeal pumping variant [Term] id: WBPhenotype:0000981 name: spermatocyte meiosis variant def: "Animals exhibit variations in the meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids (non-motile sperm) compared to control." [GO:0048137, WB:WBPaper00027300, WB:WBPerson2021] synonym: "spermatocyte division abnormal" NARROW [] synonym: "spermatocyte division variant" EXACT [] synonym: "spermatocyte meiosis abnormal" NARROW [] is_a: WBPhenotype:0000670 ! spermatogenesis variant [Term] id: WBPhenotype:0000982 name: spermatid maturation variant def: " Animals exhibit variations in the ability of a relatively unspecialized spermatocyte to acquire the properties of a spermatid cell compared to control." [WB:WBPaper00027300, WB:WBPerson2021] synonym: "spermatid maturation abnormal" NARROW [] is_a: WBPhenotype:0000670 ! spermatogenesis variant [Term] id: WBPhenotype:0000983 name: fertilization defective def: "Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) during sexual reproduction." [GO:0009566, WB:WBPerson2021] is_a: WBPhenotype:0000613 ! reproductive system physiology variant [Term] id: WBPhenotype:0000984 name: posterior pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency of the posterior body axis compared to control." [WB:WBPerson557] synonym: "posterior pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000786 ! body axis pigmentation variant [Term] id: WBPhenotype:0000985 name: blast cell physiology variant def: "Animals exhibit variations in any physical or chemical process required for the blast cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "blast cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000986 name: epithelial cell physiology variant def: "Animals exhibit variations in any physical or chemical process required for the epithelial cell to carry out its normal functions or activities, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "epithelial cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000987 name: germ cell physiology variant def: "Animals exhibit variations in any physical or chemical process required for the germ cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "germ cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000988 name: gland cell physiology variant def: "Animals exhibit variations in any physical or chemical process required for the gland cell to carry out its normal functions or activities or be able to perceive and respond to signals, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "gland cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000989 name: marginal cell physiology variant def: "Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for a marginal cell to carry out its normal function and activities or be able to perceive and respond to stimuli." [GO:0009987, WB:WBPerson557] synonym: "marginal cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000990 name: muscle cell physiology variant def: "Animals exhibit variations in any physical or chemical process required for the muscle cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "muscle cell physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000991 name: neuron physiology variant def: "Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes." [WB:WBPaper00032221, WB:WBPerson712] synonym: "neuron physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0000992 name: high sodium chloride concentration osmotic avoidance defective def: "Failure to execute the characteristic response to high concentrations of sodium chloride solution. C. elegans typically avoids high concentrations of sodium chloride solution." [WB:WBPerson2021] is_a: WBPhenotype:0001453 ! high sodium chloride concentration osmotic avoidance variant [Term] id: WBPhenotype:0000993 name: anal depressor contraction defect def: " Animals fail to contract the anal depressor muscle." [WB:WBPaper00001256] synonym: "Exp" BROAD [] is_a: WBPhenotype:0001092 ! larval defecation defect [Term] id: WBPhenotype:0000994 name: intestinal contractions variant def: "Any variations in the contraction of the enteric muscles that are involved in defecation motor program compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emc" RELATED [] synonym: "enteric muscle contraction variant" RELATED [] synonym: "intestinal contractions abnormal" NARROW [] is_a: WBPhenotype:0000210 ! defecation contraction variant [Term] id: WBPhenotype:0000996 name: expulsion defective def: "Animals exhibit defects in the expulsion of gut contents. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion." [WB:WBPaper00001256, WB:WBPaper00031246, WB:WBPerson712] synonym: "Emc" BROAD [] synonym: "Exp" BROAD [] is_a: WBPhenotype:0000205 ! expulsion variant [Term] id: WBPhenotype:0000997 name: cryophilic def: "Animals tend to track and stay within low temperature environments." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000478 ! isothermal tracking behavior variant [Term] id: WBPhenotype:0000998 name: thermophilic def: "Animals tend to track and stay within high temperature environments." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000478 ! isothermal tracking behavior variant [Term] id: WBPhenotype:0000999 name: athermotactic def: "The responses of an animal towards temperature are not influenced by its cultivation temperature." [WB:WBPerson363] is_a: WBPhenotype:0000478 ! isothermal tracking behavior variant [Term] id: WBPhenotype:0001000 name: developmental behavior variant def: "Any variation in the behavior characteristic during certain developmental stage(s) compared to control." [WB:cab] subset: phenotype_slim_wb synonym: "developmental behavior abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0001001 name: dauer behavior variant def: "Variations in the specific actions or reactions of dauer stage animals in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer behavior abnormal" NARROW [] is_a: WBPhenotype:0000819 ! postembryonic behavior variant [Term] id: WBPhenotype:0001002 name: head muscle behavior variant def: "Variations in the specific actions or reactions of the head muscles in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "head muscle behavior abnormal" NARROW [] is_a: WBPhenotype:0000595 ! head behavior variant [Term] id: WBPhenotype:0001003 name: L4 lethal def: "Animals die at the L4 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD [] is_a: WBPhenotype:0000058 ! late larval lethal [Term] id: WBPhenotype:0001004 name: pharyngeal relaxation variant def: "Any variation in the relaxation of pharyngeal muscles after contraction events compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal relaxation abnormal" NARROW [] is_a: WBPhenotype:0000634 ! pharyngeal pumping variant [Term] id: WBPhenotype:0001005 name: backward locomotion variant def: "Variations in the spontaneous or induced backward crawling locomotion of an animal compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "backward locomotion abnormal" NARROW [] is_a: WBPhenotype:0004017 ! locomotor coordination variant [Term] id: WBPhenotype:0001006 name: pharyngeal pumping rate variant def: "The number of coordinated contraction-relaxation cycles (pumps) exhibited by the pharyngeal muscle deviates from that observed for control animals." [WB:WBPaper00001709, WB:WBPerson712] synonym: "feeding rate dynamics abnormal" RELATED [] synonym: "pharyngeal pumping rate abnormal" NARROW [] synonym: "pumping rate dynamics abnormal" RELATED [] is_a: WBPhenotype:0000634 ! pharyngeal pumping variant [Term] id: WBPhenotype:0001007 name: other abnormality early emb def: "Unclassified abnormality in the inviable one- to four-cell embryo." [WB:cab] synonym: "Emb" BROAD [] synonym: "Oth" BROAD [] synonym: "other abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001008 name: male nervous system development variant def: "Variations in the progression of a set of interacting or interdependent entities forming the male nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses." [GO:0007420, WB:WBPerson2021, WB:WBPerson557] synonym: "male nervous system development abnormal" NARROW [] is_a: WBPhenotype:0000623 ! nervous system development variant [Term] id: WBPhenotype:0001009 name: developmental pigmentation variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular developmental stage of the amimal compared to control animals." [WB:WBPerson557] synonym: "developmental pigmentation abnormal" NARROW [] is_a: WBPhenotype:0000527 ! organism pigmentation variant [Term] id: WBPhenotype:0001010 name: clear def: "Animals appear unusually transparent when compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654] synonym: "Clr" BROAD [] is_a: WBPhenotype:0000527 ! organism pigmentation variant [Term] id: WBPhenotype:0001011 name: complex phenotype early emb def: " Population of unhatched eggs exhibit a complex combination of defects that do not match other class definitions." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001007 ! other abnormality early emb [Term] id: WBPhenotype:0001012 name: organism pathogen response variant def: "Animals exhibit variations in their response to disease causing agents, compared to control. Pathogen response includes prevention, damage control and recovery from the infection caused by the attack." [GO:0006952, WB:WBPaper00032196, WB:WBPerson2021, WB:WBPerson712] synonym: "bacterial load variant " NARROW [] synonym: "organism pathogen response abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0001013 name: pathogen susceptibility increased def: "Animals are more prone to infection compared to control." [WB:cab, WB:WBPaper00005370, WB:WBPaper00024299] synonym: "enhanced susceptibility to pathogens" RELATED [] synonym: "Esp" BROAD [] is_a: WBPhenotype:0001012 ! organism pathogen response variant [Term] id: WBPhenotype:0001014 name: pathogen resistance increased def: "Animals are less prone to infection compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001012 ! organism pathogen response variant [Term] id: WBPhenotype:0001015 name: developmental growth variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during any development stages compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "developmental growth abnormal" NARROW [] is_a: WBPhenotype:0000030 ! growth variant [Term] id: WBPhenotype:0001016 name: larval growth variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the larval stages compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "larval growth abnormal" NARROW [] is_a: WBPhenotype:0001015 ! developmental growth variant [Term] id: WBPhenotype:0001017 name: adult growth variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the adult stage compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "adult growth abnormal" NARROW [] is_a: WBPhenotype:0001015 ! developmental growth variant [Term] id: WBPhenotype:0001018 name: cytokinesis variant emb def: "Any variation that disrupts the cytoplasmic division of a cell during embryonic development compared to control." [GO:0000910, WB:WBPerson2021] synonym: "Cyk" BROAD [] synonym: "cytokinesis abnormal" NARROW [] is_a: WBPhenotype:0000050 ! embryonic lethal is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0001019 name: mid larval arrest def: "Animals arrest during the stage between early and late larval development. In C. elegans, mid larval arrest occurs during the L2 to L3 stages of development." [WB:cab] is_a: WBPhenotype:0000059 ! larval arrest [Term] id: WBPhenotype:0001020 name: embryonic lethal late emb def: " Animals die during the final stages of embryogenesis. In C. elegans, this lethality refers to death during the last (3-fold) stage of embryogenesis, which normally occurs 620-800 min after the first cleavage at 20C, the stage after elongation." [WB:WBPerson101] synonym: "Emb" BROAD [] synonym: "Led" BROAD [] is_a: WBPhenotype:0000050 ! embryonic lethal [Term] id: WBPhenotype:0001021 name: male sexual development variant def: "Genetically male animals exhibit deviations in the sexual program specific to males. In C. elegans, this often refers to XO animals being transformed into fertile hermaphrodites." [WB:WBPaper00000498, WB:WBPerson2021] synonym: "Her" BROAD [] synonym: "male sexual development abnormal" NARROW [] is_a: WBPhenotype:0000822 ! sex determination variant [Term] id: WBPhenotype:0001022 name: hermaphrodite sexual development variant def: "Genetically hermaphrodite animals exhibit deviations in the sexual program specific to hermaphrodites. In C. elegans, this refers to XX animals that develop as males or intersexuals instead of self-fertile hermaphrodites." [WB:WBPerson2021] synonym: "hermaphrodite sexual development abnormal" NARROW [] is_a: WBPhenotype:0000822 ! sex determination variant [Term] id: WBPhenotype:0001023 name: sexually dimorphic morphology variant def: "Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, from that observed for control animals." [GO:0009886, WB:WBPerson712] subset: phenotype_slim_wb synonym: "sexually dimorphic morphology abnormal" NARROW [] is_a: WBPhenotype:0000535 ! organism morphology variant [Term] id: WBPhenotype:0001024 name: male morphology variant def: "Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a male in the population, from that observed for control males." [GO:0009886, WB:WBPerson712] synonym: "male morphology abnormal" NARROW [] is_a: WBPhenotype:0001023 ! sexually dimorphic morphology variant [Term] id: WBPhenotype:0001025 name: hermaphrodite morphology variant def: "Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a hermaphrodite in the population, from that observed for control hermaphrodites." [GO:0009886, WB:WBPerson712] synonym: "hermaphrodite morphology abnormal" NARROW [] is_a: WBPhenotype:0001023 ! sexually dimorphic morphology variant [Term] id: WBPhenotype:0001026 name: nuclear morphology variation early emb def: "Animals exhibit variations in the form, structure or composition of the membrane enclosed organelle which contains most of the cell's genetic material during the early embryonic stage compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Nmo" BROAD [] is_a: WBPhenotype:0001035 ! nuclear appearance number defective early emb [Term] id: WBPhenotype:0001027 name: nuclear position defective early emb def: "Embryos show defects in the placement of the nucleus to a specific location within the cell." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Npo" BROAD [] synonym: "nuclear position abnormal" NARROW [] is_a: WBPhenotype:0001138 ! nucleus defective early emb [Term] id: WBPhenotype:0001028 name: nuclear appearance variant def: "The morphological appearance of nuclei differs from control animals." [WB:cab] subset: phenotype_slim_wb synonym: "nuclear appearance abnormal" NARROW [] synonym: "nuclear morphology variant" RELATED [] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0001029 name: patchy coloration def: "Animals exhibit an uneven distribution of biochromes or any other substances that cause disparate transparency/translucency compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "Pch" BROAD [] is_a: WBPhenotype:0000527 ! organism pigmentation variant [Term] id: WBPhenotype:0001030 name: pronuclear envelope defective early emb def: "Any deficiency in the lipid bilayer, the equivalent of the nuclear envelope, that surrounds each pronucleus within gametes and within the early zygote after pronuclear reformation (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Pna" BROAD [] synonym: "pronuclear envelope abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb [Term] id: WBPhenotype:0001031 name: pronuclear migration reduced early emb def: "Any variation in the movement/fusion of pronuclei in the fertilized oocyte compared to control. For example, lack of male pronuclear migration, female pronuclear migration variable, sometimes multiple female pronuclei, no or small spindle." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb [Term] id: WBPhenotype:0001032 name: larval behavior variant def: "Variations in the specific actions or reactions of a larvae in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "larval behavior abnormal" NARROW [] is_a: WBPhenotype:0000819 ! postembryonic behavior variant [Term] id: WBPhenotype:0001033 name: proximal germ cell proliferation variant def: " Any variation in the spatial pattern of proliferation and differentiation in the germ line compared to control. In C. elegans, this refers to an ectopic mass of proliferating germ cells that occupies the proximal adult germ line, a region normally occupied by gametes." [WB:WBPaper00006484, WB:WBPerson2021] synonym: "Pro" BROAD [] synonym: "proximal germ cell proliferation abnormal" NARROW [] is_a: WBPhenotype:0001215 ! germ cell mitosis variant [Term] id: WBPhenotype:0001034 name: pronuclear nuclear appearance defective early emb def: " The morphology of pronuclei and nuclei are defective in the early embryo. In C. elegans, this defect is often characterized by pronuclei and nuclei that are small or missing altogether and are often accompanied by spindle defects." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] synonym: "pronuclear nuclear appearance abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early embryonic lethal is_a: WBPhenotype:0001374 ! pronuclear nuclear appearance variant emb [Term] id: WBPhenotype:0001035 name: nuclear appearance number defective early emb def: "The size, number and organization of the components of the nuclei in the early embryo deviate from control . In C. elegans, this is characterized by nuclei that are completely missing or are significantly smaller than normal; often accompanied by spindle and cytokinesis defects." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] synonym: "nuclear appearance number abnormal" NARROW [] synonym: "nucleus abnormal emb" RELATED [] is_a: WBPhenotype:0000770 ! embryonic cell morphology variant is_a: WBPhenotype:0001138 ! nucleus defective early emb [Term] id: WBPhenotype:0001036 name: sterile F1 def: "Any variation that compromises the reproductive ability of an F1 generation animal." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001037 ! sterile progeny [Term] id: WBPhenotype:0001037 name: sterile progeny def: "Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557] synonym: "Stp" BROAD [] is_a: WBPhenotype:0000069 ! progeny variant is_a: WBPhenotype:0000688 ! sterile [Term] id: WBPhenotype:0001038 name: tumorous germline def: "Germ cells do not exit the mitotic cycle, resulting in a expansion of the unspecialized germ cell population compared to control." [WB:WBPaper00002730, WB:WBPerson2021] synonym: "Tum" BROAD [] synonym: "tumorous germ line" EXACT [] is_a: WBPhenotype:0000823 ! germline proliferation variant [Term] id: WBPhenotype:0001039 name: embryonic growth variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the embryonic stage compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "embryonic growth abnormal" NARROW [] is_a: WBPhenotype:0001015 ! developmental growth variant [Term] id: WBPhenotype:0001040 name: chemosensory response variant def: "Variations in the state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus, compared to control." [GO:0042221, WB:cab, WB:cgc3824, WB:WBPerson2021] synonym: "chemosensory response abnormal" NARROW [] is_a: WBPhenotype:0000523 ! chemical response variant is_a: WBPhenotype:0001049 ! chemosensory behavior variant [Term] id: WBPhenotype:0001041 name: meiosis defective early emb def: "Animals exhibit defects in the progression of meiosis which ultimately result in embryonic lethality." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Mei" BROAD [] synonym: "meiosis abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001042 name: neuron function reduced def: "Neurons show impaired ability in the detection, transmission, coordination or their response to information about an animal's internal and external environments." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000991 ! neuron physiology variant [Term] id: WBPhenotype:0001043 name: interphase entry defective early emb def: "Embryos do not enter or take longer to enter first interphase compared to control." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD [] synonym: "interphase entry abnormal" NARROW [] is_a: WBPhenotype:0000740 ! cell cycle variant is_a: WBPhenotype:0000775 ! meiosis variant is_a: WBPhenotype:0001041 ! meiosis defective early emb [Term] id: WBPhenotype:0001044 name: cortical dynamics defective early emb def: "Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage." [WB:cab, WB:cgc7141] synonym: "cortical dynamics abnormal" NARROW [] synonym: "Cpa" BROAD [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001045 name: sporadic pumping def: "Pharyngeal pumping contractions are brief and occur arhythmically in response to stimulus compared to control." [WB:WBPaper00001709] is_a: WBPhenotype:0000019 ! pharyngeal pumping reduced [Term] id: WBPhenotype:0001046 name: pharyngeal muscle morphology variant def: "Any variations associated with the characteristic morphology of the pharyngeal muscle such as shape, birefringence etc compared to control." [WB:WBPaper00001709] synonym: "pharyngeal muscle morphology abnormal" NARROW [] is_a: WBPhenotype:0000923 ! nonstriated muscle morphology variant [Term] id: WBPhenotype:0001047 name: aqueous positive chemotaxis variant def: "Animals exhibit variations in the movement towards typically attractive water-soluble chemicals compared to control." [WB:cab, WB:cgc3824] synonym: "aqueous positive chemotaxis abnormal" NARROW [] synonym: "water soluble chemotaxis abnormal" RELATED [] is_a: WBPhenotype:0000635 ! positive chemotaxis variant is_a: WBPhenotype:0001443 ! aqueous chemosensory response variant [Term] id: WBPhenotype:0001048 name: odorant chemosensory response variant def: "Animals exhibit variations in the chemosensory response to volatile organic compounds compared to control." [WB:WBPerson2021] synonym: "odorant chemosensory response abnormal" NARROW [] synonym: "Odr" BROAD [] synonym: "volatile chemosensory response abnormal" RELATED [] is_a: WBPhenotype:0001040 ! chemosensory response variant [Term] id: WBPhenotype:0001049 name: chemosensory behavior variant def: "Variations in behavior that is dependent upon the sensation of chemicals, compared to control." [GO:0007635, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "chemosensory behavior abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0001050 name: chemosensation variant def: "Animals exhibit variations in any of a series of events in which an organism receives a sensory chemical stimulus, converts it to a molecular signal, and recognizes and characterizes the signal, compared to control." [GO:0007606, WB:WBPerson2021] synonym: "chemosensation abnormal" NARROW [] is_a: WBPhenotype:0001049 ! chemosensory behavior variant [Term] id: WBPhenotype:0001051 name: cation positive chemotaxis variant def: "Animals exhibit variations in the characteristic movement towards typically attractive cations compared to control." [WB:cab, WB:cgc387, WB:WBPaper00000387] synonym: "cation positive chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant [Term] id: WBPhenotype:0001052 name: anion positive chemotaxis variant def: "Animals exhibit variations in the characteristic movement towards typically attractive anions compared to control." [WB:cab, WB:cgc387, WB:WBPaper00000387] synonym: "anion positive chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant [Term] id: WBPhenotype:0001053 name: cyclic nucleotide positive chemotaxis variant def: "Animals exhibit variations in the characteristic movement towards cyclic nucleotides compared to control." [WB:cab, WB:cgc387] synonym: "cyclic nucleotide positive chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant [Term] id: WBPhenotype:0001054 name: cGMP chemotaxis defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to cGMP. In C. elegans, this is characterized by the failure to move towards cGMP." [WB:cab, WB:cgc387, WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective is_a: WBPhenotype:0001464 ! cGMP chemotaxis variant [Term] id: WBPhenotype:0001055 name: bromide chemotaxis defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to bromide. In C. elegans, this is characterized by the failure to move towards bromide." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001439 ! anion positive chemotaxis defective is_a: WBPhenotype:0001457 ! bromide chemotaxis variant [Term] id: WBPhenotype:0001056 name: iodide chemotaxis defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to iodide. In C. elegans, this is characterized by the failure to move towards iodide." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001439 ! anion positive chemotaxis defective is_a: WBPhenotype:0001459 ! iodide chemotaxis variant [Term] id: WBPhenotype:0001057 name: lithium chemotaxis defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to lithium. In C. elegans, this is characterized by the failure to move towards lithium." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001440 ! cation positive chemotaxis defective [Term] id: WBPhenotype:0001058 name: potassium chemotaxis defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to potassium. In C. elegans, this is characterized by the failure of the animals to move towards potassium." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001440 ! cation positive chemotaxis defective [Term] id: WBPhenotype:0001059 name: magnesium chemotaxis defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to magnesium. In C. elegans, this is characterized by the failure to move towards magnesium." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001440 ! cation positive chemotaxis defective [Term] id: WBPhenotype:0001060 name: AWC odorant chemotaxis defective def: "In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWC compared to control." [WB:WBPerson2021] synonym: "AWC volatile chemotaxis defective" RELATED [] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective [Term] id: WBPhenotype:0001061 name: AWA odorant chemotaxis defective def: "In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWA compared to control." [WB:WBPerson2021] synonym: "AWA volatile chemotaxis defective" RELATED [] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective [Term] id: WBPhenotype:0001062 name: late paralysis arrested elongation two fold def: "In C. elegans, movement and elongation stop nearly simultaneously soon after the twofold stage of elongation. However, mutant embryos twitch at the one-and-a-half-fold stage of elongation, like control animals, and move as well as control animals at the two- fold stage." [WB:cab, WB:cgc1894] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0001063 name: egg laying phases variant def: "Fluctuation pattern between inactive, active, and egg-laying states is atypical, based on the analysis of the distribution of the log intervals of egg-laying events compared to control." [pmid:10757762, pmid:9697864, WB:cab] synonym: "egg laying phases abnormal" NARROW [] is_a: WBPhenotype:0000272 ! egg laying irregular [Term] id: WBPhenotype:0001064 name: inactive phase long def: "Animals display uncharacteristically long periods during which they do not lay eggs compared to control, usually based on the analysis of the distribution of the log intervals of egg-laying events. In C. elegans, long inactive phases can be observed in HSN-ablated and serotonin-deficient animals." [pmid:10757762, pmid:9697864, WB:cab] is_a: WBPhenotype:0000006 ! egg laying defective is_a: WBPhenotype:0001066 ! inactive phase variant [Term] id: WBPhenotype:0001065 name: fewer egg laying events during active def: "Fewer egg-laying events occur within the active phase of egg laying, based on the analysis of the distribution of the log intervals of egg-laying events, compared to control." [pmid:9697864, WB:cab] is_a: WBPhenotype:0000006 ! egg laying defective is_a: WBPhenotype:0001067 ! active phase variant [Term] id: WBPhenotype:0001066 name: inactive phase variant def: "The period during which the animal is less likely to lay eggs is not typical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab] synonym: "inactive phase abnormal" NARROW [] is_a: WBPhenotype:0001063 ! egg laying phases variant [Term] id: WBPhenotype:0001067 name: active phase variant def: "The active phase of egg-laying, the period during which animals are more likely to display multiple egg-laying events, is atypical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] synonym: "active phase abnormal" NARROW [] is_a: WBPhenotype:0001063 ! egg laying phases variant [Term] id: WBPhenotype:0001068 name: egg laying serotonin resistant def: "Animals are not induced to lay eggs in reponse to exogenous serotonin. Serotonin stimulates egg-laying in C. elegans." [WB:WBPaper00000635, WB:WBPaper00031293, WB:WBPerson712] is_a: WBPhenotype:0000024 ! serotonin resistant is_a: WBPhenotype:0001629 ! egg laying serotonin variant [Term] id: WBPhenotype:0001069 name: increased egg laying events during active def: "More eggs are laid during the active phase compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] is_a: WBPhenotype:0001067 ! active phase variant [Term] id: WBPhenotype:0001070 name: inactive phase short def: "The period during which a worm usually does not lay eggs is short compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] is_a: WBPhenotype:0001066 ! inactive phase variant [Term] id: WBPhenotype:0001071 name: active phase switch defective def: "Activation of the active phase of egg laying is defective, leading to an abnormally long inactive phase, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab] is_a: WBPhenotype:0001064 ! inactive phase long [Term] id: WBPhenotype:0001072 name: response to food variant def: "Any variation in the state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to a food stimulus, compared to control." [GO:0032094, WB:WBPerson2021] synonym: "response to food abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0001073 name: egg laying response to food variant def: "Animals exhibit variations in egg-laying behavior in response to food compared to control. In C. elegans, well-fed animals lay more eggs compared with starved animals." [pmid:10757762, WB:cab] synonym: "egg laying response to food abnormal" NARROW [] is_a: WBPhenotype:0000640 ! egg laying variant is_a: WBPhenotype:0001072 ! response to food variant [Term] id: WBPhenotype:0001074 name: vulval muscle unresponsive to serotonin def: "The vulval muscle does not respond to serotonin in the same manner as control animals. This phenotype is often assayed by imaging of calcium transients in response to serotonin." [pmid:14588249, WB:cab] is_a: WBPhenotype:0001068 ! egg laying serotonin resistant is_a: WBPhenotype:0001076 ! vulval muscle homeostasis metabolism variant [Term] id: WBPhenotype:0001075 name: vulval muscle physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the vulva muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "vulval muscle physiology abnormal" NARROW [] is_a: WBPhenotype:0000613 ! reproductive system physiology variant [Term] id: WBPhenotype:0001076 name: vulval muscle homeostasis metabolism variant def: "Variations in the chemical reactions and pathways involved in the maintenance of an internal equilibrium within the vulval muscles compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "vulval muscle homeostasis metabolism abnormal" NARROW [] is_a: WBPhenotype:0001075 ! vulval muscle physiology variant [Term] id: WBPhenotype:0001077 name: chromosome segregation variant karyomeres early emb def: "Karyomeres in AB or P1 often accompanied by weak/thin wobbly spindle." [WB:cab, WB:cgc7141] synonym: "chromosome segregation abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000773 ! chromosome segregation variant is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001078 name: cytokinesis defective early emb def: "Cytokinesis is abnormal in the first or second stages of cell division." [WB:cab, WB:cgc7141] synonym: "Cyk" BROAD [] synonym: "cytokinesis abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001018 ! cytokinesis variant emb is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001079 name: cytoplasmic dynamics defective early emb def: "Cytoplasmic movements are atypical." [WB:cab, WB:WBPerson1815] synonym: "cytoplasmic dynamics abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000769 ! cytoplasmic appearance defective early emb [Term] id: WBPhenotype:0001080 name: excessive blebbing early emb def: "Excessive shaking and movements are seen in the cell membrane or cytoplasm of one-cell or two-cell embryos." [cgc:5599, WB:cab] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001079 ! cytoplasmic dynamics defective early emb [Term] id: WBPhenotype:0001081 name: cytoplasmic morphology defective early emb def: "Morphology of the cytoplasm differs from control animals." [WB:cab, WB:WBPerson1815] synonym: "cytoplasmic morphology abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000769 ! cytoplasmic appearance defective early emb [Term] id: WBPhenotype:0001082 name: large cytoplasmic granules early emb def: "Abnormally large granules are observed in the cytoplasm of P0." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001081 ! cytoplasmic morphology defective early emb [Term] id: WBPhenotype:0001083 name: multiple cytoplasmic cavities early emb def: "Multiple vesicles, vacuoles, or cavities are seen during early embryogenesis." [cgc:5599, WB:cab] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001081 ! cytoplasmic morphology defective early emb [Term] id: WBPhenotype:0001084 name: sodium chloride chemotaxis defective def: "Failure to execute characteristic response to sodium chloride compared to control. In C. elegans, animals move towards attractive concentrations of sodium chloride." [WB:WBPaper00000119] synonym: "NaCl chemotaxis defective" EXACT [] is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective is_a: WBPhenotype:0001462 ! sodium chloride chemotaxis variant [Term] id: WBPhenotype:0001085 name: butanone chemotaxis defective def: "Failure to execute characteristic response to butanone compared to control. In C. elegans, animals move towards typically attractive concentrations of butanone." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective is_a: WBPhenotype:0001469 ! butanone chemotaxis variant [Term] id: WBPhenotype:0001086 name: trimethylthiazole chemotaxis defective def: "Failure to execute characteristic response to trimethylthiazole compared to control. In C. elegans, animals move towards typically attractive concentrations of trimethylthiazole." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective is_a: WBPhenotype:0001475 ! trimethylthiazole chemotaxis variant [Term] id: WBPhenotype:0001087 name: acetone chemotaxis defective def: "Failure to execute characteristic response to acetone compared to control. In C. elegans, animals move towards typically attractive concentrations of acetone." [WB:WBPaper00024240] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective is_a: WBPhenotype:0001465 ! acetone chemotaxis variant [Term] id: WBPhenotype:0001088 name: pentanol chemotaxis defective def: "Failure to execute characteristic response to pentanol compared to control. In C. elegans, animals move towards typically attractive concentrations of pentanol." [WB:WBPerson2021] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective is_a: WBPhenotype:0001473 ! pentanol chemotaxis variant [Term] id: WBPhenotype:0001089 name: hexanol chemotaxis defective def: "Failure to execute characteristic response to hexanol compared to control. In C. elegans, animals move towards typically attractive concentrations of hexanol." [WB:WBPerson2021] is_a: WBPhenotype:0001438 ! odorant positive chemotaxis defective is_a: WBPhenotype:0001471 ! hexanol chemotaxis variant [Term] id: WBPhenotype:0001090 name: thermotolerance reduced def: "Animals are not able to survive at temperatures above standard cultivation temperatures to the same extent as control animals." [WB:WBPerson712] synonym: "intrinsic thermotolerance reduced " NARROW [] is_a: WBPhenotype:0000146 ! organism temperature response variant [Term] id: WBPhenotype:0001091 name: larval defecation variant def: "Animals exhibit variations in the elimination of fecal matter during the larval stage compared to control animals." [WB:WBPerson2021] synonym: "larval defecation abnormal" NARROW [] is_a: WBPhenotype:0000650 ! defecation variant [Term] id: WBPhenotype:0001092 name: larval defecation defect def: "Animals fail to expel fecal matter during the larval stage." [WB:WBPerson2021] is_a: WBPhenotype:0001091 ! larval defecation variant [Term] id: WBPhenotype:0001093 name: intestinal physiology variant def: "Animals exhibit variations in any physical or chemical process required for the intestine to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "intestinal physiology abnormal" NARROW [] is_a: WBPhenotype:0000606 ! alimentary system physiology variant [Term] id: WBPhenotype:0001094 name: NaCl response variant def: "Organismal response to NaCl differs from control animals." [WB:cab] synonym: "NaCl response abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0001095 name: organism high sodium chloride hypersensitive def: "Animals respond to sodium chloride at a lower concentration or a shorter exposure compared to control animals. In C. elegans, this is often assayed through generation time and progeny number." [pmid:16027367, WB:cab] is_a: WBPhenotype:0000876 ! organism osmotic stress response variant [Term] id: WBPhenotype:0001096 name: protrusion at vulval region def: "Large protrusion at the normal position of the vulva, as seen in C. elegans lin-12 null animals." [cgc:646, WB:cab] synonym: "ventral protrusion" NARROW [] is_a: WBPhenotype:0000695 ! vulva morphology variant [Term] id: WBPhenotype:0001097 name: premature spermatocyte germ cell differentiation def: "Unspecialized male germ cells (spermatocytes) prematurely acquire the specialized properties of functional sperm." [cgc:4207, WB:cab, WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis variant [Term] id: WBPhenotype:0001098 name: no rectum def: "Animals lack the passage connecting the posterior intestine to the rectal valve." [WB:WBPaper00001423, WB:WBPerson2021] comment: WBbt:0005773. is_a: WBPhenotype:0000910 ! rectal morphology variant [Term] id: WBPhenotype:0001099 name: nose twisted def: "The extreme anterior part of the body appears distorted, usually due to uncharacteristic winding." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000321 ! nose morphology variant [Term] id: WBPhenotype:0001100 name: early embryonic lethal def: "Animal dies prior to the gastrulation stage of embryogenesis." [WB:WBPerson2021] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000050 ! embryonic lethal [Term] id: WBPhenotype:0001101 name: egg laying response to drug variant def: "Characteristic response to drugs with respect to egg-laying behavior varies compared to control." [WB:cab] synonym: "egg laying response to drug abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant is_a: WBPhenotype:0000640 ! egg laying variant [Term] id: WBPhenotype:0001102 name: mitotic spindle defective early emb def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a mitotic cell cycle." [GO:0007052, WB:WBPerson2021] comment: Possible XP. synonym: "Emb" BROAD [] synonym: "mitotic spindle abnormal" NARROW [] is_a: WBPhenotype:0000759 ! spindle defective early emb [Term] id: WBPhenotype:0001103 name: spindle absent early emb def: "Early embryos lack the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [GO:0005819, WB:WBPerson2021] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb [Term] id: WBPhenotype:0001104 name: P0 spindle absent early emb def: "No mitotic spindle is seen in P0." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001103 ! spindle absent early emb [Term] id: WBPhenotype:0001105 name: P0 spindle position defective early emb def: "Altered P0 spindle placement causes either a symmetric first division, a division in which P1 is larger than AB, or a division in which the asymmetry is exaggerated such that AB is much larger than normal." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "P0 spindle position abnormal" NARROW [] is_a: WBPhenotype:0000762 ! spindle position defective early emb [Term] id: WBPhenotype:0001106 name: spindle orientation variant AB or P1 early emb def: "The orientation of the spindle is aberrant in either the AB or the P1 cell." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "spindle orientation abnormal" NARROW [] is_a: WBPhenotype:0000760 ! spindle orientation defective early emb [Term] id: WBPhenotype:0001107 name: spindle rotation defective early emb def: "Rotation of the embryonic spindle is aberrant." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "spindle rotation abnormal" NARROW [] is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb [Term] id: WBPhenotype:0001108 name: P0 spindle rotation failure early emb def: "P0 spindle fails to rotate and extends perpendicular to the long axis of the embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001107 ! spindle rotation defective early emb [Term] id: WBPhenotype:0001109 name: P0 spindle rotation delayed early emb def: "P0 spindle rotates late in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000438 ! retarded heterochronic variations is_a: WBPhenotype:0001107 ! spindle rotation defective early emb [Term] id: WBPhenotype:0001110 name: aster defective early emb def: "Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores." [GO:0005818, WB:WBPerson2021, WB:WBPerson557] synonym: "aster abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001111 name: aster AB defective early emb def: "Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the AB cell." [WB:WBPerson2021, WB:WBPerson557] synonym: "aster AB abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001110 ! aster defective early emb [Term] id: WBPhenotype:0001112 name: aster AB resembles P1 aster early emb def: "The morphology of the AB aster resembles that of the P1 aster in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001111 ! aster AB defective early emb [Term] id: WBPhenotype:0001113 name: P1 aster defective early emb def: "Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the P1 cell." [WB:cab, WB:cgc5599, WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "P1 aster abnormal" NARROW [] is_a: WBPhenotype:0001110 ! aster defective early emb [Term] id: WBPhenotype:0001114 name: cell cycle defective early emb def: "The progression of biochemical and morphological processes that occur during successive replication or nuclear replication events is disrupted during the early embryonic stage." [WB:WBPerson2021, WB:WBPerson557] synonym: "cell cycle abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000740 ! cell cycle variant is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001115 name: cell cycle timing defective early emb def: "Cell cycle timing is abnormal during the first four cell divisions." [WB:cab, WB:WBPerson1815] synonym: "cell cycle timing abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001114 ! cell cycle defective early emb [Term] id: WBPhenotype:0001116 name: absolute cell cycle timing defective early emb def: "Absolute cell cycle timing during the first four cell divisions is aberrant." [WB:WBPerson557] synonym: "absolute cell cycle timing abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001115 ! cell cycle timing defective early emb [Term] id: WBPhenotype:0001117 name: cell cell contacts defective early emb def: "Cell-cell contacts are abnormal in the early embryo." [WB:cab, WB:WBPerson1815] synonym: "cell cell contacts abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001118 name: cell position defective early emb def: "Cell position is abnormal in the early embryo." [WB:cab, WB:WBPerson1815] synonym: "cell position abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001119 name: cell cycle slow early emb def: "Embryos take longer to divide during the first and second cell divisions." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000438 ! retarded heterochronic variations is_a: WBPhenotype:0001116 ! absolute cell cycle timing defective early emb [Term] id: WBPhenotype:0001120 name: relative cell cycle timing defective early emb def: "Relative cell cycle timing during the first four cell divisions is aberrant." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "relative cell cycle timing abnormal" NARROW [] is_a: WBPhenotype:0001115 ! cell cycle timing defective early emb [Term] id: WBPhenotype:0001121 name: exaggerated asynchrony early emb def: "Asynchrony of the second division is exaggerated and P1 divides more slowly than normal." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb [Term] id: WBPhenotype:0001122 name: reversed asynchrony early emb def: "P1 divides before AB." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb [Term] id: WBPhenotype:0001123 name: synchronous second division early emb def: "AB and P1 divide synchronously." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb [Term] id: WBPhenotype:0001124 name: ABa ABp EMS synchronous division early emb def: "EMS divides at the same time that ABa and ABp divide." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb [Term] id: WBPhenotype:0001125 name: P2 EMS synchronous division early emb def: "P2 and EMS divide synchronously." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb [Term] id: WBPhenotype:0001126 name: cell cell contacts variant four emb def: "Aba, ABp, EMS, or P1 contacts fewer of its sister cells than in control embryos." [WB:cab, WB:cgc5599] synonym: "cell cell contacts abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001117 ! cell cell contacts defective early emb [Term] id: WBPhenotype:0001127 name: EMS anterior extension fails early emb def: "The EMS blastomere fails to extend anteriorly and make extensive contact (hug) with the ABa blastomere." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001118 ! cell position defective early emb [Term] id: WBPhenotype:0001128 name: EMS anterior extension extreme early emb def: "EMS extends too far anteriorly at the four cell stage." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001118 ! cell position defective early emb [Term] id: WBPhenotype:0001129 name: cleavage furrow defective early emb def: "Embryos exhibit defects in the formation or maintenance of the groove in the cell surface near the old metaphase plate during cytokinesis." [GO:0032154, WB:WBPerson2021, WB:WBPerson2987, WB:WBPerson557] synonym: "cleavage furrow abnormal" RELATED [] synonym: "cleavage furrow abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001078 ! cytokinesis defective early emb [Term] id: WBPhenotype:0001130 name: cytokinesis fails early emb def: "Cells of the embryo attempt to divide but fail to form two daughter cells." [WB:cab, WB:cgc5599] synonym: "Cyk" BROAD [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001078 ! cytokinesis defective early emb [Term] id: WBPhenotype:0001131 name: loose mitotic furrow early emb def: "Once formed, the mitotic furrow can \"slide\"laterally." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb [Term] id: WBPhenotype:0001132 name: ectopic cleavage furrows early emb def: "Extra cleavage furrows are seen in one or all cells of a one-cell to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb [Term] id: WBPhenotype:0001133 name: division axis defective early emb def: "Division axis within the first four divisions is not normal." [WB:cab, WB:WBPerson1815] synonym: "division axis abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001134 name: Aba ABp division axis defective early emb def: "ABa or ABp divide in the wrong orientation." [WB:cab, WB:cgc5599] synonym: "Aba ABp division axis abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001133 ! division axis defective early emb [Term] id: WBPhenotype:0001135 name: embryonic morphology defective early emb def: "Animals exhibit defects in the form, structure or composition of any of its parts during the early embryonic stage." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "embryonic morphology abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early embryonic lethal is_a: WBPhenotype:0001136 ! embryonic morphology variant [Term] id: WBPhenotype:0001136 name: embryonic morphology variant def: "Animals exhibit variations in the form, structure or composition of any of its parts during any developmental stage ranging from zygote formation to hatching compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "embryonic morphology abnormal" NARROW [] is_a: WBPhenotype:0000037 ! egg morphology variant [Term] id: WBPhenotype:0001137 name: embryos small early emb def: "Embryos are produced that are less than fifty percent of the size of control embryos." [WB:cab, WB:WBPaper00005599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001135 ! embryonic morphology defective early emb [Term] id: WBPhenotype:0001138 name: nucleus defective early emb def: "Nucleus is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "nucleus abnormal" NARROW [] is_a: WBPhenotype:0001034 ! pronuclear nuclear appearance defective early emb [Term] id: WBPhenotype:0001139 name: nuclear envelope assembly variant early emb def: "Nuclear envelope does not reassemble properly." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "nuclear reassembly abnormal" NARROW [] synonym: "nuclear reassembly defective early emb" RELATED [] is_a: WBPhenotype:0001138 ! nucleus defective early emb [Term] id: WBPhenotype:0001140 name: neuron migration variant def: "Any variation in the normal orderly movement of neurons from one site to another compared to control." [WB:WBPerson2021] synonym: "neuron migration abnormal" NARROW [] is_a: WBPhenotype:0000594 ! cell migration variant [Term] id: WBPhenotype:0001141 name: nucleus reforms cell division remnant early emb def: "After division of either one-cell or two-cell embryos, the nuclei reappear next to the cell division remnant." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001027 ! nuclear position defective early emb [Term] id: WBPhenotype:0001142 name: nuclear number defective early emb def: "Nuclear number is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "nuclear number abnormal" NARROW [] is_a: WBPhenotype:0001035 ! nuclear appearance number defective early emb [Term] id: WBPhenotype:0001143 name: multiple nuclei early emb def: "Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "karyomeres" RELATED [] synonym: "Mul" BROAD [] synonym: "multiple nuclei in early embryo emb" RELATED [] is_a: WBPhenotype:0000746 ! cell division variant is_a: WBPhenotype:0001142 ! nuclear number defective early emb is_a: WBPhenotype:0001894 ! nuclear number variant [Term] id: WBPhenotype:0001144 name: polar body number size early emb def: "Defects are either seen in the number or size of the polar bodies in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001147 ! polar body defective early emb [Term] id: WBPhenotype:0001145 name: polar body number defective early emb def: "Polar body number is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "polar body number abnormal" NARROW [] is_a: WBPhenotype:0001144 ! polar body number size early emb [Term] id: WBPhenotype:0001146 name: polar body size defective early emb def: "Polar body size is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "polar body size abnormal" NARROW [] is_a: WBPhenotype:0001144 ! polar body number size early emb [Term] id: WBPhenotype:0001147 name: polar body defective early emb def: "Polar bodies are abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "polar body abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001148 name: polar body reabsorbed early emb def: "Polar body is reabsorbed in the one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000777 ! polar body extrusion defective early emb [Term] id: WBPhenotype:0001149 name: polar body reabsorbed first early emb synonym: "Emb" BROAD [] is_obsolete: true [Term] id: WBPhenotype:0001150 name: polar body reabsorbed one two early emb def: "A polar body is reabsorbed in either the one cell- or the two-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001148 ! polar body reabsorbed early emb [Term] id: WBPhenotype:0001151 name: pronucleus centrosomes defective early emb def: "Pronucleus is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "pronucleus centrosomes abnormal" NARROW [] is_a: WBPhenotype:0001034 ! pronuclear nuclear appearance defective early emb [Term] id: WBPhenotype:0001152 name: pronuclear migration defective early emb def: "Pronucleus migration is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "pronuclear migration abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb [Term] id: WBPhenotype:0001153 name: pronuclear migration failure early emb def: "Neither of the pronuclei migrate and they never meet." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb [Term] id: WBPhenotype:0001154 name: paternal pronucleus migrates early emb def: "Instead of the maternal pronucleus migrating to the posterior end of the one-cell embryo, the paternal pronucleus migrates to meet the maternal pronucleus in the anterior end." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb [Term] id: WBPhenotype:0001155 name: pronuclei meet centrally early emb def: "The maternal and paternal pronuclei meet more centrally instead of meeting in the posterior end of the embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb [Term] id: WBPhenotype:0001156 name: pronuclear size defective early emb def: "Maternal or paternal pronucleus is either too small or too large." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "pronuclear size abnormal" NARROW [] is_a: WBPhenotype:0001159 ! pronuclear morphology defective early emb [Term] id: WBPhenotype:0001157 name: pronuclear breakdown defective early emb def: "Pronuclear breakdown is atypical in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "pronuclear breakdown abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb [Term] id: WBPhenotype:0001158 name: pronuclear breakdown asynchronous early emb def: "Instead of breaking down synchronously, the two pronuclei break down asynchronously in the inviable one-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001157 ! pronuclear breakdown defective early emb [Term] id: WBPhenotype:0001159 name: pronuclear morphology defective early emb def: "Pronucleus morphology is atypical in the inviable embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "pronuclear morphology abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb [Term] id: WBPhenotype:0001160 name: pronuclear envelope morphology defective early emb def: "Morphology of the pronuclear envelope is atypical in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "pronuclear envelope morphology abnormal" NARROW [] is_a: WBPhenotype:0001159 ! pronuclear morphology defective early emb [Term] id: WBPhenotype:0001161 name: maternal pronucleus indistinct early emb def: "Maternal pronucleus has a blurry appearance. The nuclear envelope does not have a crisp circular shape." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001160 ! pronuclear envelope morphology defective early emb [Term] id: WBPhenotype:0001162 name: pronuclear number defective early emb def: "There are more than two pronuclei in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "pronuclear number abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus centrosomes defective early emb [Term] id: WBPhenotype:0001163 name: pronucleus formation failure early emb def: "Either the maternal or paternal pronucleus is absent." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001162 ! pronuclear number defective early emb [Term] id: WBPhenotype:0001164 name: excess pronucleus early emb def: "There is either more than one maternal or paternal pronucleus in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001162 ! pronuclear number defective early emb [Term] id: WBPhenotype:0001165 name: excess maternal pronucleus early emb def: "One-cell embryos have two or more maternal pronuclei." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001164 ! excess pronucleus early emb [Term] id: WBPhenotype:0001166 name: excess paternal pronucleus variant centrosome early emb def: "More than one paternal pronucleus is present in the inviable one-cell embryo or there is a defect in centrosome structure." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "excess paternal pronucleus abnormal" NARROW [] is_a: WBPhenotype:0001164 ! excess pronucleus early emb [Term] id: WBPhenotype:0001167 name: pseudocleavage defective early emb def: "Pseudocleavage is atypical in the inviable one-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD [] synonym: "pseudocleavage abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001168 name: pseudocleavage absent early emb def: "No pseudocleavage is observed before or during pronuclear migration." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "no pseudocleavage" RELATED [] is_a: WBPhenotype:0001167 ! pseudocleavage defective early emb [Term] id: WBPhenotype:0001169 name: pseudocleavage exaggerated early emb def: "Embryos have more pronounced pseudocleavage than normal." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001167 ! pseudocleavage defective early emb [Term] id: WBPhenotype:0001170 name: sterile F0 48 hours post injection def: "Injected worm stops producing embryos 48 hours after RNAi injection and contains no live/developing embryos at this time." [WB:cab, WB:cgc5599] synonym: "P0 sterile" NARROW [] synonym: "Ste" BROAD [] is_a: WBPhenotype:0000689 ! maternal sterile [Term] id: WBPhenotype:0001171 name: shortened life span def: "The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712] synonym: "Age" BROAD [] synonym: "longevity decreased" RELATED [] is_a: WBPhenotype:0000039 ! life span variant [Term] id: WBPhenotype:0001172 name: programmed cell death variant def: "Developmentally regulated termination of a cell or cell group does not occur as in control animals." [WB:WBPerson712] synonym: "programmed cell death abnormal" NARROW [] is_a: WBPhenotype:0000729 ! cell death variant [Term] id: WBPhenotype:0001173 name: non apoptotic cell death variant def: "Animals exhibit variations in the specific activation or halting of processes within a cell that occur through necrosis or programmed cell death pathways different from apoptosis, so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death, compared to control." [GO:0008219, WB:WBPerson712] synonym: "non apoptotic cell death abnormal" NARROW [] is_a: WBPhenotype:0001172 ! programmed cell death variant [Term] id: WBPhenotype:0001174 name: chromosome disjunction defective def: "Chromosomes fail to segregate away from their homolog, resulting in gametes with no or extra copies of the chromosome." [WB:WBPerson712] synonym: "chromosome disjunction abnormal" NARROW [] is_a: WBPhenotype:0001499 ! meiotic chromosome segregation variant is_a: WBPhenotype:0001882 ! aneuploidy is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0001175 name: high incidence male progeny def: "Higher numbers of male progeny occur in the population as a result of an increase in X chromosome nondisjunction compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPerson712] synonym: "high frequency X chromosome nondisjunction" RELATED [] synonym: "Him" BROAD [] is_a: WBPhenotype:0001664 ! X chromosome nondisjunction [Term] id: WBPhenotype:0001176 name: one cell shape defective early emb def: "One-cell embryos have an altered shape." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "one cell shape abnormal" NARROW [] is_a: WBPhenotype:0001135 ! embryonic morphology defective early emb [Term] id: WBPhenotype:0001177 name: embryo osmotic pressure sensitive early emb def: "Embryos rupture when placed on a 2% agar pad and covered with a coverslip." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001178 ! egg integrity defective early emb [Term] id: WBPhenotype:0001178 name: egg integrity defective early emb def: "The structure of the egg is impaired, flawed or no longer intact." [WB:WBPerson2021, WB:WBPerson557] synonym: "egg integrity abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001179 name: No variantity scored def: "Phenotypic examination of worms did not reveal an obvious abnormality compared with control animals." [WB:cab] comment: The phenotype ontology was restructured such that "Abnormal" is now the root term. The term "Abnormal" with a "Not" qualifier is a suggested replacement for this term. synonym: "No abnormal" NARROW [] synonym: "WT" RELATED [] is_obsolete: true [Term] id: WBPhenotype:0001180 name: accumulated germline cell corpses def: "Animals exhibit an increase in the quantity of germ line cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712] is_a: WBPhenotype:0000241 ! accumulated cell corpses [Term] id: WBPhenotype:0001181 name: accumulated somatic cell corpses def: "Animals exhibit an increase in the quantity of non-germ line cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712] is_a: WBPhenotype:0000241 ! accumulated cell corpses [Term] id: WBPhenotype:0001182 name: fat content variant def: "Animals exhibit variations in the amount of fat or lipids present in the organism compared to control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712] synonym: "fat content abnormal" NARROW [] is_a: WBPhenotype:0000725 ! lipid metabolism variant [Term] id: WBPhenotype:0001183 name: fat content reduced def: "Animals exhibit less fat or lipid than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712] is_a: WBPhenotype:0001182 ! fat content variant [Term] id: WBPhenotype:0001184 name: fat content increased def: "Animals exhibit a greater amount of fat or lipids than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712] is_a: WBPhenotype:0001182 ! fat content variant [Term] id: WBPhenotype:0001185 name: embryonic developmental delay early emb def: "The developmental progression of an early embryo over time, from its formation to its mature structure is delayed compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000438 ! retarded heterochronic variations is_a: WBPhenotype:0001100 ! early embryonic lethal [Term] id: WBPhenotype:0001186 name: embryo delayed at pronuclear contact early emb def: "Embryos are either delayed or arrested at pronuclear contact." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001185 ! embryonic developmental delay early emb [Term] id: WBPhenotype:0001187 name: division EMS before P2 early emb def: "EMS divides before P2." [WB:WBPerson557] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001120 ! relative cell cycle timing defective early emb [Term] id: WBPhenotype:0001188 name: radial filament structure variant pharynx def: "Animals exhibit variations in the form, structure or composition of radial arrangement of actin within the pharyngeal muscle compared to control animals." [WB:WBPaper00026850, WB:WBPerson2021, WB:WBPerson557] synonym: "radial filament structure abnormal" NARROW [] is_a: WBPhenotype:0001046 ! pharyngeal muscle morphology variant [Term] id: WBPhenotype:0001189 name: adherens junctions variant pharyngeal muscle def: "Any variation in the cell junctions of the pharyngeal muscle at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control." [WB:WBPaper00026850, WB:WBPerson2021, WB:WBPerson557] synonym: "adherens junctions abnormal" NARROW [] is_a: WBPhenotype:0001046 ! pharyngeal muscle morphology variant is_a: WBPhenotype:0001745 ! adherens junction variant [Term] id: WBPhenotype:0001190 name: pharyngeal physiology variant def: "Animals exhibit variations in any physical or chemical process required for the pharynx to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "pharyngeal physiology abnormal" NARROW [] is_a: WBPhenotype:0000606 ! alimentary system physiology variant [Term] id: WBPhenotype:0001191 name: pharyngeal muscle physiology variant def: "Animals exhibit variations in any physical or chemical process required for muscles in the pharynx to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "pharyngeal muscle physiology abnormal" NARROW [] is_a: WBPhenotype:0001190 ! pharyngeal physiology variant [Term] id: WBPhenotype:0001192 name: calcium signaling pharynx variant def: "Any variation in the series of molecular signals in which a pharyngeal cell uses calcium ions to convert an extracellular signal into a response, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "calcium signaling pharynx abnormal" NARROW [] is_a: WBPhenotype:0001191 ! pharyngeal muscle physiology variant [Term] id: WBPhenotype:0001193 name: disorganized pharyngeal EPG def: "Electropharyngeograms do not show a similar pattern as control animals. C. elegans animals show a repeating regular pattern in which each pump is associated with an excitatory depolarizing wave, often punctuated by brief negative spikes, followed by a plateau phase, and ending with an inhibitory hyperpolarizing wave." [WB:cab, WB:cgc7545] is_a: WBPhenotype:0000980 ! pharyngeal contraction variant [Term] id: WBPhenotype:0001194 name: ectopic neuron def: "Animals have extra neurons, which are present in places they are normally not found, when compared to the number or location of these neurons in control animals." [WB:WBPaper00027335, WB:WBPerson712] is_a: WBPhenotype:0001303 ! ectopic cell [Term] id: WBPhenotype:0001195 name: generation calcium signal defective pharynx def: "Rhythmic calcium increases in the pharynx are observed less often than in control animals. In C. elegans, rhythmic increases in intracellular calcium are often observed using a transgenically expressed cameleon, a ratiometric calcium indicator." [WB:cab, WB:cgc4194, WB:cgc7545] is_a: WBPhenotype:0001192 ! calcium signaling pharynx variant [Term] id: WBPhenotype:0001196 name: synchronization calcium signal defective pharynx def: "Calcium spikes lack synchrony in the musculature of the corpus and the terminal bulb as seen in control." [WB:cab, WB:cgc7545] is_a: WBPhenotype:0001192 ! calcium signaling pharynx variant [Term] id: WBPhenotype:0001197 name: somatic gonad physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic gonad to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "somatic gonad physiology abnormal" NARROW [] is_a: WBPhenotype:0000613 ! reproductive system physiology variant [Term] id: WBPhenotype:0001198 name: somatic sheath physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic sheath system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "somatic sheath physiology abnormal" NARROW [] is_a: WBPhenotype:0001197 ! somatic gonad physiology variant [Term] id: WBPhenotype:0001199 name: gonad sheath contractions variant def: "Animals exhibit variations in any physical or chemical process required for the contraction of a thin continuous tube surrounding the proximal portions of the ovary and covering the maturing oocytes to the near portion of the distal gonad arm, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "gonad sheath contractions abnormal" NARROW [] is_a: WBPhenotype:0001198 ! somatic sheath physiology variant [Term] id: WBPhenotype:0001200 name: gonad sheath contraction rate reduced def: "Basal contraction rate and or peak contraction rate of the gonadal sheath is reduced relative to control animals." [WB:cab, WB:cgc7545] is_a: WBPhenotype:0001199 ! gonad sheath contractions variant [Term] id: WBPhenotype:0001201 name: no expulsion defecation def: "Animals lack the stereotyped muscle contractions that result in the opening of anus." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000391 ! defecation missing motor steps [Term] id: WBPhenotype:0001202 name: nicotine hypersensitive def: "Animals respond to nicotine at lower concentrations or shorter exposure compared to control. Nicotine is a cholinergic agonist." [WB:cab, WB:cgc7388, WB:WBPerson557] is_a: WBPhenotype:0001573 ! nicotine response variant is_a: WBPhenotype:0001579 ! cholinergic agonist hypersensitive [Term] id: WBPhenotype:0001203 name: nicotine resistant def: "Animals fail to respond to the concentration of nicotine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:cab, WB:cgc7388, WB:WBPerson557] is_a: WBPhenotype:0001573 ! nicotine response variant is_a: WBPhenotype:0001578 ! cholinergic agonist resistant [Term] id: WBPhenotype:0001204 name: muscimol resistant def: "Animals fail to respond to the concentration of muscimol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant is_a: WBPhenotype:0002047 ! muscimol response variant [Term] id: WBPhenotype:0001205 name: muscimol hypersensitive def: "Animals respond to muscimol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive is_a: WBPhenotype:0002047 ! muscimol response variant [Term] id: WBPhenotype:0001206 name: movement variant def: "Variations in the process by which an organism travels from one location to another compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "movement abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0001207 name: protein signaling variant def: "Any variation in a series of protein mediated signals that help relay information within the cell, and thereby affecting changes in the functioning of the cell, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "protein signaling abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0001208 name: RNAi resistant def: "Animals show reduced susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000743 ! RNAi response variant [Term] id: WBPhenotype:0001209 name: skiddy def: "Apparently normal sinusoidal movement, but appear to have poor traction on the agar surface of a culture plate." [WB:cab, WB:WBPaper00026735] synonym: "Skd" BROAD [] is_a: WBPhenotype:0001701 ! spastic locomotion [Term] id: WBPhenotype:0001210 name: pericellular component physiology variant def: "Animals exhibit variations in any physical or chemical process taking place in extracellular spaces within or associated with the organism, from that observed for control animals." [WB:WBPerson712] subset: phenotype_slim_wb synonym: "pericellular component physiology abnormal" NARROW [] is_a: WBPhenotype:0000519 ! physiology variant [Term] id: WBPhenotype:0001211 name: cuticle integrity variant def: "The physical strength or function of the cuticle is varies from that observed for control animals." [WB:WBPerson712] synonym: "cuticle integrity abnormal" NARROW [] is_a: WBPhenotype:0001678 ! cuticle physiology variant [Term] id: WBPhenotype:0001212 name: cuticle fragile def: "The strength of the cuticle is less robust than that observed for control animals. In C. elegans the strength of the cuticle is often assayed by it's ability to protect the animal from exposure to bleach or other compounds." [WB:WBPerson712] is_a: WBPhenotype:0001211 ! cuticle integrity variant [Term] id: WBPhenotype:0001213 name: locomotion reduced def: "Animals exhibit a decrease in any parameter used to measure locomotion compared to control animals." [WB:cab] synonym: "movement reduced" EXACT [] is_a: WBPhenotype:0000641 ! activity level variant [Term] id: WBPhenotype:0001214 name: metaphase to anaphase transition fails is_obsolete: true [Term] id: WBPhenotype:0001215 name: germ cell mitosis variant def: "Variations in the mitotic expansion of germ cell populations or in the appearance of nuclei during development in the premeiotic region of the germline compared to control." [WB:WBPaper00001007, WB:WBPaper00005486, WB:WBPerson2021] synonym: "germ cell mitosis abnormal" NARROW [] is_a: WBPhenotype:0000823 ! germline proliferation variant [Term] id: WBPhenotype:0001216 name: meiosis metaphase to anaphase transition block def: "Oocyte chromosomes arrest in metaphase of meiosis I without transitioning to anaphase or producing polar bodies." [pmid:11134076, WB:cab] synonym: "Mat" BROAD [] is_a: WBPhenotype:0000776 ! passage through meiosis defective early emb is_a: WBPhenotype:0001496 ! metaphase to anaphase transition defect [Term] id: WBPhenotype:0001217 name: germ cell mitosis metaphase to anaphase transition block def: "Germ line cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0001215 ! germ cell mitosis variant is_a: WBPhenotype:0001497 ! mitotic metaphase to anaphase transition defect [Term] id: WBPhenotype:0001218 name: cell death sexually dimorphic variant def: "Animals exhibit variations in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations." [WB:WBPerson712] synonym: "cell death sexually dimorphic abnormal" NARROW [] is_a: WBPhenotype:0000730 ! apoptosis variant [Term] id: WBPhenotype:0001219 name: cell survival sexually dimorphic increased def: "Animals exhibit a decrease in the rate or extent of programmed cell death and thus an increase in cell survival, as it pertains to a sex-specific feature, compared to control populations." [WB:WBPerson712] is_a: WBPhenotype:0001218 ! cell death sexually dimorphic variant [Term] id: WBPhenotype:0001220 name: cell death sexually dimorphic increased def: "Animals exhibit in increase in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations." [WB:WBPerson712] is_a: WBPhenotype:0001218 ! cell death sexually dimorphic variant [Term] id: WBPhenotype:0001221 name: nose touch defective def: "Animal fails to exhibit characteristic response after a nose-on collision with an object compared to control. In C. elegans, this is usually assayed with a hair or similar fiber. The nose is the anterior most tip of the animal." [WB:WBPaper00001705, WB:WBPerson557] synonym: "Not" BROAD [] is_a: WBPhenotype:0000456 ! touch resistant is_a: WBPhenotype:0004026 ! nose touch variant [Term] id: WBPhenotype:0001222 name: transposon mutator def: "Animals exhibit an increase in frequency of transposition events (DNA movement to different positions within the genome of a single cell) causing an accumulation of lesions within the genome, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "Mut" RELATED [] synonym: "mutator" RELATED [] is_a: WBPhenotype:0000228 ! spontaneous mutation rate increased [Term] id: WBPhenotype:0001223 name: germline RNAi resistant def: "Animals show reduced susceptibility to gene silencing in the germline triggered by double stranded RNA (RNAi), compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001208 ! RNAi resistant [Term] id: WBPhenotype:0001224 name: axon outgrowth variant def: "Any variation in the processes that govern the extension of axons compared to control." [GO:0048675, WB:WBPerson2021] synonym: "axon migration variant" RELATED [] synonym: "axon outgrowth abnormal" NARROW [] is_a: WBPhenotype:0000572 ! neuronal outgrowth variant [Term] id: WBPhenotype:0001225 name: phasmid socket absent def: "Animals are missing the interfacial hypodermal cell (socket cell) of the phasmid sensillum pore." [WB:WBPaper00000938, WB:WBPaper00004350, WB:WBPaper00026656, WB:WBPerson712] synonym: "Psa" RELATED [] is_a: WBPhenotype:0000257 ! phasmid morphology variant [Term] id: WBPhenotype:0001226 name: commissure variant def: "Animals display variations in the structure, organization or path of the part of the axon that forms a bridge between body regions, compared to that in control animals." [WB:WBPaper00000938, WB:WBPaper00001576, WB:WBPaper00029065, WB:WBPerson712] synonym: "commissure abnormal" NARROW [] is_a: WBPhenotype:0000181 ! axon trajectory variant [Term] id: WBPhenotype:0001227 name: commissure absent def: "Animals are missing any one of its commissures, an axon tract that connects one body part to another." [WB:WBPaper00027335, WB:WBPerson712] is_a: WBPhenotype:0001226 ! commissure variant [Term] id: WBPhenotype:0001228 name: alae absent def: "Animals lack the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000202 ! alae variant [Term] id: WBPhenotype:0001229 name: anterior neuron migration defective def: "The orderly movement of neurons along the anterior axis of the animal is abolished, misdirected or incomplete compared to control." [WB:WBPerson2021] synonym: "abnormal anterior neuron migration" NARROW [] is_a: WBPhenotype:0001140 ! neuron migration variant [Term] id: WBPhenotype:0001230 name: anterior cell migration defective def: "The orderly movement of cells along the anterior axis of the animal is abolished, misdirected or incomplete compared to control." [WB:WBPerson2021] synonym: "abnormal anterior cell migration" NARROW [] is_a: WBPhenotype:0000594 ! cell migration variant [Term] id: WBPhenotype:0001231 name: intraflagellar transport accelerated def: "The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is increased compared to control." [WB:WBPerson2021] synonym: "ift accelerated" RELATED [] is_a: WBPhenotype:0000853 ! intraflagellar transport variant [Term] id: WBPhenotype:0001232 name: serotonin response variant def: "Animals exhibit variations in the response to the addition of serotonin compared to that observed in control animals. Serotonin is a monoamine neurotransmitter." [WB:WBPerson557] synonym: "serotonin response abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001233 name: DAPI staining variant def: "Animals exhibit variations in the pattern of a chemical nuclear stain which is commonly used in fixed specimens and produces a bright blue label, compared to control. DAPI (4'-6-Diamidino-2-phenylindole) forms fluorescent complexes with natural double-stranded DNA (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "DAPI staining abnormal" NARROW [] is_a: WBPhenotype:0010002 ! cell organization biogenesis variant [Term] id: WBPhenotype:0001234 name: nonanone chemotaxis defective def: "Failure to execute the characteristic response to nonanone compared to control. In C. elegans, nonanone is a repellant." [WB:WBPaper00002917] is_a: WBPhenotype:0001448 ! odorant negative chemotaxis defective is_a: WBPhenotype:0001456 ! nonanone chemotaxis variant [Term] id: WBPhenotype:0001235 name: cell division polarity variant def: "Any variation in the orientation of the physical partitioning and separation of a cell into daughter cells compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "cell division polarity abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0001236 name: transgene expression increased def: "Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] is_a: WBPhenotype:0000962 ! level of transgene expression variant [Term] id: WBPhenotype:0001237 name: ectopic axon outgrowth def: "Any perturbation that causes an increase in the frequency of axon outgrowth compared to control. As a result, an excess number of axonal projections are generated." [GO:0030517, WB:WBPerson2021] is_a: WBPhenotype:0000629 ! ectopic neurite outgrowth is_a: WBPhenotype:0001224 ! axon outgrowth variant [Term] id: WBPhenotype:0001238 name: male mating latency variant def: "Any variation in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva." [pmid:16624900, WB:cab] synonym: "male mating latency abnormal" NARROW [] is_a: WBPhenotype:0000648 ! male mating variant [Term] id: WBPhenotype:0001239 name: mating latency increased def: "Any increase in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva." [pmid:16624900] is_a: WBPhenotype:0001238 ! male mating latency variant is_a: WBPhenotype:0001414 ! male mating defective [Term] id: WBPhenotype:0001240 name: male tail sensory ray differentiation variant def: "Variations in the processes leading to the specialization of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "male tail sensory ray differentiation abnormal" NARROW [] is_a: WBPhenotype:0000199 ! male tail sensory ray development variant [Term] id: WBPhenotype:0001242 name: intraflagellar transport slow def: "The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is lower compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000854 ! intraflagellar transport defective [Term] id: WBPhenotype:0001243 name: intraflagellar transport distance short def: "The bidirectional transport of molecules (cargo) along axonemal microtubules is reduced compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001247 ! anterograde transport defective [Term] id: WBPhenotype:0001244 name: intraflagellar transport absent def: "Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is completely abolished." [WB:WBPerson2021] is_a: WBPhenotype:0000854 ! intraflagellar transport defective [Term] id: WBPhenotype:0001245 name: no transport middle segment cilia def: "The bidirectional transport of molecules along the middle segment of axonemal microtubules of the cilia is absent." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001243 ! intraflagellar transport distance short [Term] id: WBPhenotype:0001246 name: no transport distal segment cilia def: "The bidirectional transport of molecules along the distal segment of axonemal microtubules of the cilia is absent." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001243 ! intraflagellar transport distance short [Term] id: WBPhenotype:0001247 name: anterograde transport defective def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons is disrupted." [WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. is_a: WBPhenotype:0000854 ! intraflagellar transport defective is_a: WBPhenotype:0001477 ! anterograde transport variant [Term] id: WBPhenotype:0001248 name: wing cilia morphology variant def: "Animals exhibit variations in the structure or organization of the microtuble-based projections that in control animals invaginate individually into the sheath cell of the neuronal sensillum rather than projecting through the socket cell to the outside. In C. elegans, the cilia of each wing cell has its own unique shape and as they are not exposed to the outside, they do not typically take up dyes." [WB:WBPaper00000932, WB:WBPaper00029016, WB:WBPerson712] synonym: "AWC cilia morphology abnormal" RELATED [] synonym: "wing cilia morphology abnormal" NARROW [] is_a: WBPhenotype:0000615 ! cilia morphology variant [Term] id: WBPhenotype:0001249 name: amphid channel cilia morphology variant def: "Animals exhibit variations in the structure or composition of the dendritic projections of the amphid sensory neurons that traverse the sensillum pore to connect with the outside of the animal, compared to that observed in control animals. In C. elegans, amphid channel cilia morphology is frequently assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000932, WB:WBPerson712] synonym: "amphid channel cilia morphology abnormal" NARROW [] is_a: WBPhenotype:0000615 ! cilia morphology variant [Term] id: WBPhenotype:0001250 name: amphid channel axoneme morphology variant def: "Animals exhibit variations in the structure or composition of the microtuble-based fibrillar core, axoneme, of the cilia of the neurons that project through the sensillum pore to the outside of the animal, compared to that observed in control animals." [WB:WBPaper00000932, WB:WBPerson712] synonym: "amphid channel axoneme morphology abnormal" NARROW [] is_a: WBPhenotype:0000262 ! axoneme morphology variant is_a: WBPhenotype:0001249 ! amphid channel cilia morphology variant [Term] id: WBPhenotype:0001251 name: amphid channel axoneme short def: "The microtuble-based fibrillar-bundles of the amphid sensory cilia are reduced in length compared to those in control animals." [WB:WBPaper00000932, WB:WBPaper00027116, WB:WBPerson712] is_a: WBPhenotype:0001250 ! amphid channel axoneme morphology variant [Term] id: WBPhenotype:0001252 name: wing cilia axoneme morphology variant def: "Animals exhibit variations in the structure or organization of the microtubule-based fibrillar section, axoneme, of the cilia of the flat sheet-like cells associated with sensory function, from that observed in control animals." [WB:WBPerson712] synonym: "wing cilia axoneme morphology abnormal" NARROW [] is_a: WBPhenotype:0001248 ! wing cilia morphology variant [Term] id: WBPhenotype:0001253 name: wing cilia axoneme short def: "The microtuble-based fibrillar-bundle, axoneme, of the wing cell cilia are reduced in length and do not extend into the sheath cell as far as they do in control animals." [WB:WBPerson712] is_a: WBPhenotype:0001252 ! wing cilia axoneme morphology variant [Term] id: WBPhenotype:0001254 name: amphid channel cilia bulbous def: "The dendritic processes that normally extend through the amphid sensillum pore to the outside are truncated and have swollen ends as opposed to the extended and finger-like tips of channel cilia in control animals." [WB:WBPaper00027116, WB:WBPerson712] is_a: WBPhenotype:0001249 ! amphid channel cilia morphology variant [Term] id: WBPhenotype:0001255 name: wing cilia bulbous def: "Animals exhibit wing cell sensory cilia that are truncated and swollen unlike that observed in control animals." [WB:WBPaper00027116, WB:WBPerson712] is_a: WBPhenotype:0001248 ! wing cilia morphology variant [Term] id: WBPhenotype:0001256 name: DNA damage induced focus formation variant def: "Variations in the aggregation of molecules at the site of DNA strand breakage or damage compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "DNA damage induced focus formation abnormal" NARROW [] synonym: "DNA repair induced focus formation" RELATED [] is_a: WBPhenotype:0000739 ! DNA damage response variant [Term] id: WBPhenotype:0001257 name: cross link induced focus formation variant def: "Variations in the generation of foci that mark sites of aberrant bonding of molecules to the DNA strand, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "cross link induced focus formation abnormal" NARROW [] is_a: WBPhenotype:0001256 ! DNA damage induced focus formation variant [Term] id: WBPhenotype:0001258 name: RNAi enhanced def: "Animals show increased susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control." [WB:WBPerson2021] synonym: "Eri" RELATED [] is_a: WBPhenotype:0000743 ! RNAi response variant [Term] id: WBPhenotype:0001259 name: hermaphrodite fertility reduced def: "Hermaphrodites exhibit a reduction in the production of new individuals owing to defects in gamete competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000806 ! hermaphrodite fertility variant [Term] id: WBPhenotype:0001260 name: oocyte morphology variant def: "Haploid female germ cells (oocytes) exhibit variations in their overall structure, appearance or contents compared to control." [WB:WBPaper00001883, WB:WBPerson2021] synonym: "oocyte morphology abnormal" NARROW [] is_a: WBPhenotype:0000900 ! germ cell morphology variant [Term] id: WBPhenotype:0001261 name: pale def: "Animals show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000527 ! organism pigmentation variant [Term] id: WBPhenotype:0001262 name: vulval development incomplete def: "The developmental progression of the egg-laying organ of female and hermaphrodite nematodes is halted prior to the formation of the mature structure." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000699 ! vulva development variant [Term] id: WBPhenotype:0001263 name: peroxisome morphology variant def: "The morphological appearance of peroxisomes is variant compared to control animals." [WB:cab] synonym: "peroxisome morphology abnormal" NARROW [] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0001264 name: peroxisome physiology variant def: "Animals exhibit variations in any physical or chemical process required for the peroxisome to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "peroxisome physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0001265 name: head movement variant def: "The anterior portion of the animal exhibits variations in its movement compared to control." [WB:WBPaper00000214] synonym: "Erratic head vibration" NARROW [] synonym: "head movement abnormal" NARROW [] is_a: WBPhenotype:0001699 ! localized movement variant [Term] id: WBPhenotype:0001266 name: genetic pathway activation variant def: "Any variation in triggering of the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "genetic pathway activation abnormal" NARROW [] is_a: WBPhenotype:0000074 ! genetic pathway variant [Term] id: WBPhenotype:0001267 name: induced contraction rate variant def: "Any variation in the frequency of gonad sheath contractions triggered by internal or external stimuli compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "induced contraction rate abnormal" NARROW [] is_a: WBPhenotype:0001199 ! gonad sheath contractions variant [Term] id: WBPhenotype:0001268 name: induced cell death variant def: "Animals exhibit variations in the extent of activation of programmed cell death, compared to control." [WB:WBPerson712] synonym: "induced cell death abnormal" NARROW [] is_a: WBPhenotype:0000729 ! cell death variant [Term] id: WBPhenotype:0001269 name: pathogen induced cell death variant def: "Animals exhibit variations in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control." [WB:WBPerson712] synonym: "pathogen induced cell death abnormal" NARROW [] is_a: WBPhenotype:0001268 ! induced cell death variant [Term] id: WBPhenotype:0001270 name: pathogen induced cell death reduced def: "Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0001269 ! pathogen induced cell death variant [Term] id: WBPhenotype:0001271 name: pathogen induced death increased def: "Animals are more prone to lethality as a result of infection compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001013 ! pathogen susceptibility increased [Term] id: WBPhenotype:0001272 name: vulval cell induction variant def: "Vulval precursor cells inappropriately adopt fates that are normally restricted to other vulval precursor cells compared to control." [WB:WBPerson2021] synonym: "vulval cell induction abnormal" NARROW [] synonym: "vulval precursor cell induction abnormal" EXACT [] is_a: WBPhenotype:0000220 ! vulva cell fate specification variant [Term] id: WBPhenotype:0001273 name: organism heat response variant def: "Any variation in the state or activity of an organism (in terms of movement, gene expression, etc.) in response to heat (high temperatures above the optimal temperature for that organism), compared to control." [GO:0009408, WB:WBPerson2021] synonym: "organism heat response abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0001274 name: organism heat hypersensitive def: "Animals respond to heat at a lower temperature or a shorter exposure time compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001273 ! organism heat response variant [Term] id: WBPhenotype:0001275 name: increased genetic pathway signal def: "Any variation that increases the magnitude of a signal generated by a set of gene interactions in a given pathway, compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000074 ! genetic pathway variant [Term] id: WBPhenotype:0001276 name: ectopic expression transgene def: "Any variation in the cellular expression of a gene product produced by exogenous DNA that has been introduced into the organism such that it now expresses in cells/tissues not seen when compared to the expression of that gene product in control animals." [WB:WBPerson557] is_a: WBPhenotype:0000961 ! pattern of transgene expression variant [Term] id: WBPhenotype:0001277 name: transformer def: "XX animals are transformed into males or pseudomales ." [WB:cab, WB:WBPerson712] synonym: "Tra" RELATED [] is_a: WBPhenotype:0001572 ! masculinized [Term] id: WBPhenotype:0001278 name: transgene expression reduced def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] is_a: WBPhenotype:0000962 ! level of transgene expression variant [Term] id: WBPhenotype:0001279 name: transgene expression reduced male def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the male, that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] is_a: WBPhenotype:0001278 ! transgene expression reduced [Term] id: WBPhenotype:0001280 name: transgene expression reduced hermaphrodite def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the hermaphrodite, that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] is_a: WBPhenotype:0001278 ! transgene expression reduced [Term] id: WBPhenotype:0001281 name: stuffed pharynx def: "Pharynx becomes clogged with food. In C. elegans, this is often a result of pharyngeal pumping defects." [WB:cab] is_a: WBPhenotype:0000634 ! pharyngeal pumping variant is_a: WBPhenotype:0000778 ! feeding inefficient [Term] id: WBPhenotype:0001282 name: mitochondrial metabolism variant def: "Variations in the chemical reactions and pathways of the mitochondria compared to control." [WB:WBPerson2021] synonym: "mitochondrial metabolism abnormal" NARROW [] is_a: WBPhenotype:0001283 ! organelle metabolism variant [Term] id: WBPhenotype:0001283 name: organelle metabolism variant def: "Variations in the chemical reactions and pathways of an organelle compared to control." [WB:WBPerson2021] synonym: "organelle metabolism abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0001284 name: coenzyme Q depleted def: "Animals contain a lower level of coenzyme Q, an oil-soluble vitamin-like substance present in most eukaryotic cells, primarily in the mitochondria, compared to control. It is a component of the electron transport chain and participates in aerobic cellular respiration." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000026 ! lipid depleted is_a: WBPhenotype:0001282 ! mitochondrial metabolism variant [Term] id: WBPhenotype:0001285 name: induced pharyngeal pumping variant def: "Pharyngeal pumping is not influenced by treatment with specific compounds (eg: serotonin) in the same manner as control animals." [WB:WBPerson2021] synonym: "induced pharyngeal pumping abnormal" NARROW [] is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant [Term] id: WBPhenotype:0001286 name: food suppressed pumping variant def: "Exposure to food does not reduce pharyngeal pumping to the same extent as observed in control animals." [WB:WBPerson2021] synonym: "food suppressed pumping abnormal" NARROW [] is_a: WBPhenotype:0001072 ! response to food variant is_a: WBPhenotype:0001287 ! suppressed pharyngeal pumping defective [Term] id: WBPhenotype:0001287 name: suppressed pharyngeal pumping defective def: "Animals do not exhibit a decrease in pumping rate when treated with specific compounds (such as pheromones) as is observed for control animals." [WB:WBPaper00032082, WB:WBPerson712] synonym: "suppressed pharyngeal pumping abnormal" NARROW [] is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant [Term] id: WBPhenotype:0001289 name: acetylcholinesterase inhibitor resistant def: "Animals fail to respond to the concentration of acetylcholinesterase inhibitor that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant is_a: WBPhenotype:0001290 ! acetylcholinesterase inhibitor response variant [Term] id: WBPhenotype:0001290 name: acetylcholinesterase inhibitor response variant def: "Animals exhibit variations in their response to a specific acetylcholinesterase inhibitor compared to that observed in control animals." [WB:WBPerson557] synonym: "acetylcholinesterase inhibitor response abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001291 name: social behavior variant def: "Animals exhibit variations in actions and responses that occurs predominantly, or only, in individuals that are part of a group, from that observed for animals in a control group." [GO:0035176, WB:WBPerson712] synonym: "social behavior abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0001292 name: body wall muscle physiology variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the body wall muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "body wall muscle physiology abnormal" NARROW [] is_a: WBPhenotype:0000611 ! muscle system physiology variant [Term] id: WBPhenotype:0001293 name: larval physiology variant def: "Animals exhibit variations in any physical or chemical process required for the larva to carry out its normal metabolic functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "larval physiology abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism physiology variant [Term] id: WBPhenotype:0001294 name: head bent def: "The most anterior portion of the animal is not aligned with the axis of the body." [WB:WBPaper00000031] is_a: WBPhenotype:0000071 ! head morphology variant [Term] id: WBPhenotype:0001295 name: body twisted def: "Any portion of the animal, between the head and the tail, appears distorted, usually due to uncharacteristic winding." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000072 ! body morphology variant [Term] id: WBPhenotype:0001296 name: lannate resistant def: "Animals fail to respond to the concentration of lannate that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001289 ! acetylcholinesterase inhibitor resistant [Term] id: WBPhenotype:0001297 name: male tail development variant def: "Any variation in the process whose specific outcome is the progression of the male tail over time, from its formation to the mature structure, compared to control." [WB:WBPerson2021] synonym: "male tail development abnormal" NARROW [] is_a: WBPhenotype:0000805 ! tail development variant [Term] id: WBPhenotype:0001298 name: hindgut morphology variant def: "Animals exhibit variations in the form, structure or composition of the more posterior portion of the intestine, just anterior to the sphincter valve, which is subject to squeezing by the somatal-intestinal muscles compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "hindgut morphology abnormal" NARROW [] is_a: WBPhenotype:0000710 ! intestinal morphology variant [Term] id: WBPhenotype:0001299 name: cell division variant male def: "Any variation that alters the physical partitioning and separation of a cell into daughter cells in male animals compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "cell division abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0001300 name: germ cell cytoplasmic morphology variant def: "Any variation in the composition or structure of the contents within a germ cell, excluding the plasma membrane and nucleus, compared to control. Germ cells include sperm, oocytes, and their precursors." [GO:0005737, WB:WBPerson2021, WB:WBPerson557] synonym: "germ cell cytoplasmic morphology abnormal" NARROW [] is_a: WBPhenotype:0000900 ! germ cell morphology variant [Term] id: WBPhenotype:0001301 name: P granule defective def: "Localization or structural appearance of P-granules is altered compared to control. P-granules are cytoplasmic structures associated with germ nuclei in the C. elegans gonad, and are localized exclusively to germ cells, or germ cell precursors, throughout the life cycle." [pmid:11262230, WB:cab] synonym: "P granule abnormal" NARROW [] is_a: WBPhenotype:0001300 ! germ cell cytoplasmic morphology variant [Term] id: WBPhenotype:0001302 name: P granule localization defective def: "The restricted localization of P granules to germ cells or germ cell precursors is altered compared to control." [WB:WBPaper00001477, WB:WBPerson2021] synonym: "germ granule localization defective" RELATED [] synonym: "P granule localization abnormal" NARROW [] is_a: WBPhenotype:0001301 ! P granule defective [Term] id: WBPhenotype:0001303 name: ectopic cell def: "Animals have extra cells, which are present in places they are normally not found, when compared to the number or location of these cells in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000529 ! cell development variant [Term] id: WBPhenotype:0001304 name: hindgut damaged def: "The terminal portion of the intestine exhibits structural defects such as scarring or blockage." [WB:cab, WB:WBPaper00003719] synonym: "Scar" BROAD [] is_a: WBPhenotype:0001298 ! hindgut morphology variant [Term] id: WBPhenotype:0001305 name: hook morphology variant def: "Any variation in the form or composition of the structure that lies on the ventral surface just anterior and central to the base of the spicule openings (small lump on the gubernaculum of the male tail) and contains a sensory structure called the hook sensillum, compared to control. In C. elegans the hook is necessary for proper male mating." [WB:WBPerson2021, WB:WBPerson557] synonym: "hook morphology abnormal" NARROW [] is_a: WBPhenotype:0000070 ! male tail morphology variant [Term] id: WBPhenotype:0001306 name: male reproductive system morphology variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the male reproductive system compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents." [WB:WBPerson2021, WB:WBPerson557] synonym: "male reproductive system morphology abnormal" NARROW [] is_a: WBPhenotype:0000605 ! reproductive system morphology variant [Term] id: WBPhenotype:0001307 name: reduced body bend def: "The maximum ventral and dorsal flex of the animal is reduced compared to that observed for control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001703 ! body bend variant [Term] id: WBPhenotype:0001308 name: weak pumping def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding is not as robust as compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000634 ! pharyngeal pumping variant [Term] id: WBPhenotype:0001309 name: flat locomotion path def: "Animals show a decrease in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "flattened locomotion path" EXACT [] is_a: WBPhenotype:0004022 ! amplitude of movement variant [Term] id: WBPhenotype:0001310 name: neuron positioning variant def: "The placement of neuronal cells, as a whole or of a specific class of neuron in the animal, deviates from that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuron positioning abnormal" NARROW [] is_a: WBPhenotype:0000604 ! nervous system morphology variant [Term] id: WBPhenotype:0001311 name: protein expression reduced hermaphrodite def: "Variations that result in a decrease in protein expression in hermaphrodites compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein expression reduced [Term] id: WBPhenotype:0001312 name: neuron number variant def: "The quantity of neuronal cells, as a whole or of a specific class of neuron in the animal deviates from that observed in control animals." [WB:WBPaper00027711, WB:WBPerson712] synonym: "neuron number abnormal" NARROW [] is_a: WBPhenotype:0000604 ! nervous system morphology variant [Term] id: WBPhenotype:0001313 name: uterine muscle variant def: "Any variation in the progression of the sex-specific muscles of the hermaphrodite, over time, whose contractions squeeze on the uterus to help move eggs towards the vulval opening compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "uterine muscle abnormal" NARROW [] is_a: WBPhenotype:0000282 ! hermaphrodite sex muscle development variant [Term] id: WBPhenotype:0001314 name: vulval muscle variant def: "Any variation in the progression of the sex-specific muscles in the hermaphrodite, over time, that are specialized for egg-laying compared to control. In C. elegans the contractions of the vulval muscles open the lips of the vulva to help in expelling an egg from the uterus (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "vulval muscle abnormal" NARROW [] is_a: WBPhenotype:0000282 ! hermaphrodite sex muscle development variant [Term] id: WBPhenotype:0001315 name: electrophysiology variant def: "Animals exhibit variations in the electrical properties of any of its cells or tissues compared to control." [WB:WBPerson2021] synonym: "electrophysiology abnormal" NARROW [] is_a: WBPhenotype:0000519 ! physiology variant [Term] id: WBPhenotype:0001316 name: evoked postsynaptic current variant def: "Variations in the synaptic currents that are elicited by firing an action potential in a population of axons, compared to control." [pmid:14735116, WB:WBPerson2021] synonym: "evoked postsynaptic current abnormal" NARROW [] is_a: WBPhenotype:0001315 ! electrophysiology variant [Term] id: WBPhenotype:0001317 name: evoked postsynaptic amplitude reduced def: "The amplitudes of synaptic currents that are elicited by firing an action potential in a population of axons are decreased, compared to those observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001316 ! evoked postsynaptic current variant [Term] id: WBPhenotype:0001318 name: endogenous synaptic events variant def: "Any variation in the currents observed in the absence of presynaptic action potentials and that are elicited by fusion of a single endogenous vesicle of transmitter compared to control." [pmid:14735116, WB:WBPerson2021] synonym: "endogenous synaptic events abnormal" NARROW [] is_a: WBPhenotype:0001315 ! electrophysiology variant [Term] id: WBPhenotype:0001319 name: endogenous synaptic event frequency reduced def: "The rate (frequency) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is decreased compared to control. Changes in frequency are indicative of presynaptic modifications." [pmid:14735116, WB:WBPaper00026938, WB:WBPerson2021] is_a: WBPhenotype:0001318 ! endogenous synaptic events variant [Term] id: WBPhenotype:0001320 name: endogenous synaptic amplitude variant def: "The amplitude (magnitude) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is altered compared to control. Changes in amplitude are often interpreted as alterations of postsynaptic responsiveness to the transmitter." [pmid:14735116, WB:WBPerson2021] synonym: "endogenous synaptic amplitude abnormal" NARROW [] is_a: WBPhenotype:0001318 ! endogenous synaptic events variant [Term] id: WBPhenotype:0001321 name: presynaptic region morphology variant def: "Animals display variations in the structure, configuration, distribution or ratio of the components of the vesicle-filled varicosities of the synapse compared to control." [GO:0042734, WB:WBPaper00000938, WB:WBPaper00027305, WB:WBPaper00028886, WB:WBPerson712] synonym: "presynaptic region morphology abnormal" NARROW [] is_a: WBPhenotype:0000616 ! synapse morphology variant [Term] id: WBPhenotype:0001322 name: vesicle number reduced def: "Total presynaptic vesicle number is reduced, possibly refecting a defect in the replenishment of synaptic vesicles compared to control." [pmid:16803962, WB:cab] comment: Electron microscopic analysis. is_a: WBPhenotype:0001332 ! vesicle number variant [Term] id: WBPhenotype:0001323 name: vesicle morphology variant def: "Animals display variations in the shape or size of their vesicles, which are spherical, membrane-bound fluid-filled organelles, compared to vesicles observed in control animals." [GO:0031982, pmid:16803962, WB:cab, WB:WBPaper00027612, WB:WBPaper00027711, WB:WBPerson712] comment: Electron microscopic analysis. synonym: "vesicle morphology abnormal" NARROW [] is_a: WBPhenotype:0001671 ! vesicle organization variant [Term] id: WBPhenotype:0001324 name: cell ionizing radiation response variant def: "Cells exhibit variations in their response to ionizing radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "cell ionizing radiation response abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell stress response variant [Term] id: WBPhenotype:0001325 name: backing not sustained def: "Animals initiate but do not continue backward movement, similar to control animals." [WB:cab, WB:cgc914] is_a: WBPhenotype:0001005 ! backward locomotion variant [Term] id: WBPhenotype:0001326 name: cell gamma ray response variant def: "Cells exhibit variations in their response to gamma ray radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "cell gamma ray response abnormal" NARROW [] is_a: WBPhenotype:0001324 ! cell ionizing radiation response variant [Term] id: WBPhenotype:0001327 name: cell gamma ray hypersensitive def: "Cells respond to a lower dosage of gamma rays or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001326 ! cell gamma ray response variant [Term] id: WBPhenotype:0001328 name: posterior body dumpy def: "The posterior part of the worm is shorter and stouter compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000793 ! posterior body morphology variant [Term] id: WBPhenotype:0001329 name: curly def: "Animals exhibit a greater number of bends in their body compared to control. C. elegans posture assumes more than a single sine wave." [WB:cab, WB:cgc914] is_a: WBPhenotype:0000001 ! body posture variant [Term] id: WBPhenotype:0001330 name: egg laying event infrequent def: "The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate is reduced compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "egg laying event rare" RELATED [] is_a: WBPhenotype:0000006 ! egg laying defective is_a: WBPhenotype:0000272 ! egg laying irregular [Term] id: WBPhenotype:0001331 name: motor neuron morphology variant def: "Animals display variations in the structure or organization of components of the motor neuron, internal to the cell itself or in relation to the cellular environment compared to that observed in control animals. A motor neuron is a neuronal cell that synapses to an effector (muscle, gland etc.)." [WB:WBPerson712] comment: WBbt:0005409. synonym: "motor neuron morphology abnormal" NARROW [] is_a: WBPhenotype:0000905 ! neuron morphology variant [Term] id: WBPhenotype:0001332 name: vesicle number variant def: "Animals display variations in the number of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "vesicle number abnormal" NARROW [] is_a: WBPhenotype:0001671 ! vesicle organization variant [Term] id: WBPhenotype:0001333 name: neuron cell body absent misplaced def: "The body of a neuron is not where it should be when compared to control animals; it is absent or misplaced." [WB:WBPaper00000502, WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0000816 ! neuron development variant [Term] id: WBPhenotype:0001334 name: hermaphrodite sex muscle morphology variant def: "Any variation in the form, structure or composition of the muscles of the adult hermaphrodite reproductive system compared to control. In C. elegans hermaphrodites these muscles include the vulval and uterine muscles, located near the vulva in the midbody, which all derive from the M myoblast (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite sex muscle morphology abnormal" NARROW [] is_a: WBPhenotype:0001335 ! hermaphrodite reproductive system morphology variant [Term] id: WBPhenotype:0001335 name: hermaphrodite reproductive system morphology variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the hermaphrodite reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents." [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite reproductive system morphology abnormal" NARROW [] is_a: WBPhenotype:0000605 ! reproductive system morphology variant [Term] id: WBPhenotype:0001336 name: male mating efficiency eliminated def: "Males sire no cross progeny." [WB:WBPaper00000179, WB:WBPaper00000608, WB:WBPerson557] synonym: "no male progeny" EXACT [] is_a: WBPhenotype:0000843 ! male mating efficiency reduced [Term] id: WBPhenotype:0001337 name: adrenergic receptor antagonist response variant def: "Animals exhibit variations in their response to a specific adrenergic receptor antagonist compared to that observed in control animals." [WB:WBPerson557] synonym: "adrenergic receptor antagonist response abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001338 name: phentolamine resistant def: "Animals fail to respond to the concentration of phentolamine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001337 ! adrenergic receptor antagonist response variant [Term] id: WBPhenotype:0001339 name: egg laying levamisole resistant def: "Animals are not induced to lay eggs in reponse to exogenous levamisole. In C. elegans, levamisole stimulates egg-laying." [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0000421 ! levamisole resistant is_a: WBPhenotype:0001101 ! egg laying response to drug variant [Term] id: WBPhenotype:0001340 name: egg laying imipramine resistant def: "Animals are not induced to lay eggs in reponse to exogenous imipramine. In C. elegans, imipramine stimulates egg-laying." [WB:WBPaper00000635, WB:WBPaper00001133, WB:WBPaper00031293, WB:WBPerson712] is_a: WBPhenotype:0000340 ! imipramine resistant is_a: WBPhenotype:0001101 ! egg laying response to drug variant [Term] id: WBPhenotype:0001341 name: egg laying phentolamine resistant def: "Animals are not induced to lay eggs in reponse to exogenous phentolamine. In C. elegans, phentolamine stimulates egg-laying." [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0001101 ! egg laying response to drug variant is_a: WBPhenotype:0001338 ! phentolamine resistant [Term] id: WBPhenotype:0001342 name: egg laying imipramine hypersensitive def: "Animals respond to exogenous imipramine at a lower concentration or within a shorter time period than control animals under the same conditions." [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0001101 ! egg laying response to drug variant [Term] id: WBPhenotype:0001343 name: meiotic spindle defective early emb def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a meiotic cell cycle." [GO:0000212, WB:WBPerson2021] comment: Possible XP. synonym: "meiotic spindle abnormal" NARROW [] is_a: WBPhenotype:0000759 ! spindle defective early emb [Term] id: WBPhenotype:0001344 name: organelle organization biogenesis variant def: "Intracellular membrane bound compartments vary in shape or size from that observed in control animals." [WB:WBPaper00032168, WB:WBPerson712] synonym: "organelle organization biogenesis abnormal" NARROW [] is_a: WBPhenotype:0010002 ! cell organization biogenesis variant [Term] id: WBPhenotype:0001345 name: cytoskeleton organization biogenesis variant def: "Animals exhibit variations in the form, structure, composition or arrangement of any of the various filamentous elements that form the internal framework of cells, compared to control. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GO:0005856, WB:WBPerson2021, WB:WBPerson557] synonym: "cytoskeleton organization biogenesis abnormal" NARROW [] is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant [Term] id: WBPhenotype:0001346 name: actin cytoskeleton dynamics variant def: "Any variation in the dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins compared to control." [GO:0031532, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "actin cytoskeleton dynamic abnormal" NARROW [] is_a: WBPhenotype:0001587 ! actin organization biogenesis variant [Term] id: WBPhenotype:0001347 name: intestinal calcium signaling variant def: "Any variation in the series of molecular signals in which an intestinal cell uses calcium ions to convert an extracellular signal into a response, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "intestinal calcium signaling abnormal" NARROW [] is_a: WBPhenotype:0001093 ! intestinal physiology variant [Term] id: WBPhenotype:0001348 name: chromosome morphology variant def: "Variations in the form or composition of a structure in the cell nucleus which contains the genetic material encoded as DNA and surrounded by histone proteins and other regulatory elements compared to control. In C. elegans the normal cell contains 5 pairs of 'autosomes' and one or two X chromosomes (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "chromosome morphology abnormal" NARROW [] is_a: WBPhenotype:0001028 ! nuclear appearance variant [Term] id: WBPhenotype:0001349 name: protein phosphorylation variant def: "Variations in the processes that incorporate phosphate groups to one or more amino acids within a protein, compared to control." [GO:0006468, WB:WBPerson2021] synonym: "protein phosphorylation abnormal" NARROW [] is_a: WBPhenotype:0001382 ! protein modification variant [Term] id: WBPhenotype:0001350 name: protein phosphorylation increased def: "Animals exhibit higher levels of protein phosphorylation compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001349 ! protein phosphorylation variant [Term] id: WBPhenotype:0001351 name: protein phosphorylation reduced def: "Animals exhibit decreased levels of protein phosphorylation compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001349 ! protein phosphorylation variant [Term] id: WBPhenotype:0001352 name: endoplasmic reticulum metabolism variant def: "Variations in the chemical reactions and pathways of the endoplasmic reticulum compared to control." [WB:WBPerson2021] synonym: "endoplasmic reticulum metabolism abnormal" NARROW [] synonym: "er metabolism abnormal" RELATED [] is_a: WBPhenotype:0001283 ! organelle metabolism variant [Term] id: WBPhenotype:0001353 name: centration defective early emb def: "The coordinated movement during prophase of the two centrosomes and the two pronuclei towards the center of the one cell embryo is abolished." [WB:WBPaper00027230, WB:WBPerson2021, WB:WBPerson557] synonym: "centration abnormal" NARROW [] is_a: WBPhenotype:0001152 ! pronuclear migration defective early emb [Term] id: WBPhenotype:0001354 name: actin cytoskeleton filament morphology variant def: "Animals exhibit variations in the form, structure, composition or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "actin cytoskeleton filament morphology abnormal" NARROW [] is_a: WBPhenotype:0001587 ! actin organization biogenesis variant [Term] id: WBPhenotype:0001355 name: gonad morphology variant def: "Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "gonad morphology abnormal" NARROW [] is_a: WBPhenotype:0000605 ! reproductive system morphology variant [Term] id: WBPhenotype:0001356 name: male sex muscle morphology variant def: "Any variation in the form, structure or composition of the muscles of the adult male reproductive system compared to control. In C. elegans males, the M myoblast gives rise to a much larger set of specialized muscles, compared to hermaphrodites, which differentiate within the tail region (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "male sex muscle morphology abnormal" NARROW [] is_a: WBPhenotype:0001024 ! male morphology variant [Term] id: WBPhenotype:0001357 name: male gonad morphology variant def: "Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male gametes compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "male gonad morphology abnormal" NARROW [] is_a: WBPhenotype:0001024 ! male morphology variant [Term] id: WBPhenotype:0001358 name: male nervous system morphology variant def: "Male animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "male nervous system morphology abnormal" NARROW [] is_a: WBPhenotype:0001024 ! male morphology variant [Term] id: WBPhenotype:0001359 name: proctodeum morphology variant def: "Animals exhibit variations in the structure and organization of the chamber in the male tail that extends from the termination of four canals (vas deferens, gut, and left and right spicule channels) to just before the cloaca, from that observed in control animals." [WB:WBPaper00027278, WB:WBPerson712] synonym: "proctodeum morphology abnormal" NARROW [] is_a: WBPhenotype:0000070 ! male tail morphology variant [Term] id: WBPhenotype:0001360 name: hermaphrodite self sterile def: "Hermaphrodites fail to produce any viable progeny via self-fertilization. However, such hermaphrodites can successfully reproduce if mated to control males." [WB:WBPaper00001075, WB:WBPerson2021] is_a: WBPhenotype:0000694 ! hermaphrodite sterile [Term] id: WBPhenotype:0001361 name: chromosome condensation variant def: "Any variation in the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells compared to control." [GO:0030261, WB:WBPerson2021, WB:WBPerson557] synonym: "chromosome condensation abnormal" NARROW [] is_a: WBPhenotype:0001743 ! mitosis variant is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0001362 name: chromosome condensation failure def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis in eukaryotic cells is abolished." [GO:0030261, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001361 ! chromosome condensation variant [Term] id: WBPhenotype:0001363 name: head cavity def: "The head contains cavities, possibly indicative of inappropriate cell death." [WB:cab] synonym: "head vacuole" RELATED [] is_a: WBPhenotype:0000071 ! head morphology variant [Term] id: WBPhenotype:0001364 name: male fan morphology variant def: "Any variation in the form, structure or composition of the flattened structure extending laterally at the extreme tip of the adult male consisting of nine pairs of sensory rays that lie within a web-like cuticle compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "male fan morphology abnormal" NARROW [] is_a: WBPhenotype:0000070 ! male tail morphology variant [Term] id: WBPhenotype:0001365 name: male bursa development variant def: "Any variation in the process whose specific outcome is the progression of the male bursa over time, from its formation to the mature structure, compared to control." [WB:WBPerson2021] synonym: "male bursa development abnormal" NARROW [] is_a: WBPhenotype:0001297 ! male tail development variant [Term] id: WBPhenotype:0001366 name: male fan development variant def: "Any variation in the process whose specific outcome is the progression of the male fan over time, from its formation to the mature structure, compared to control." [WB:WBPerson2021] synonym: "male fan development abnormal" NARROW [] is_a: WBPhenotype:0001297 ! male tail development variant [Term] id: WBPhenotype:0001367 name: proctodeum development variant def: "Any variation in the process whose specific outcome is the progression of the male proctodeum over time, from its formation to the mature structure, compared to control. The union of the vas deferens and the intestine give rise to the proctodeum which contains copulatory spicules." [WB:WBPerson2021] synonym: "proctodeum development abnormal" NARROW [] is_a: WBPhenotype:0001297 ! male tail development variant [Term] id: WBPhenotype:0001368 name: spermatheca absent def: "Animals lack the somatic gonad structure that connects the distal gonad arm to the uterus." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001662 ! spermatheca development variant [Term] id: WBPhenotype:0001369 name: protein interaction variant def: "Variations in the selective and non-covalent physical association between two or more proteins, or a protein and nucleic acid/macromolecular complex, compared to control." [GO:0005515, WB:WBPerson2021] synonym: "protein interaction abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0001370 name: protein protein interaction variant def: "Variations in the selective and non-covalent physical association between two or more proteins, compared to control." [WB:WBPerson2021] synonym: "protein protein interaction abnormal" NARROW [] is_a: WBPhenotype:0001369 ! protein interaction variant [Term] id: WBPhenotype:0001371 name: protein RNA interaction variant def: "Variations in the selective and non-covalent physical association between a protein and a specific RNA sequence, compared to control." [WB:WBPerson2021] synonym: "protein RNA interaction abnormal" NARROW [] is_a: WBPhenotype:0001369 ! protein interaction variant [Term] id: WBPhenotype:0001372 name: protein DNA interaction variant def: "Variations in the selective and non-covalent physical association between a protein and a specific DNA sequence, compared to control." [WB:WBPerson2021] synonym: "protein DNA interaction abnormal" NARROW [] is_a: WBPhenotype:0001369 ! protein interaction variant [Term] id: WBPhenotype:0001373 name: protein rna interaction abolished def: "Animals lack a specific protein-RNA interaction observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001371 ! protein RNA interaction variant [Term] id: WBPhenotype:0001374 name: pronuclear nuclear appearance variant emb def: "The shape and size of nuclei as well as the distribution of nucleoporins are strongly affected." [WB:cab, WB:WBPaper00028895] synonym: "Pna" RELATED [] synonym: "pronuclear nuclear appearance abnormal" NARROW [] is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant [Term] id: WBPhenotype:0001375 name: transgene expression undetectable def: "The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection." [WB:WBPerson557] is_a: WBPhenotype:0001278 ! transgene expression reduced [Term] id: WBPhenotype:0001376 name: transgene expression undetectable cell specific def: "The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection in specific cells." [WB:WBPerson557] is_a: WBPhenotype:0001375 ! transgene expression undetectable [Term] id: WBPhenotype:0001377 name: break induced focus formation variant def: "Variations in the generation of foci that mark crossover recombination events, compared to control. These foci mark the boundary of asymmetric synaptonemal complex disassembly." [WB:WBPaper00032296, WB:WBPerson2021, WB:WBPerson557] synonym: "break induced focus formation abnormal" NARROW [] is_a: WBPhenotype:0001256 ! DNA damage induced focus formation variant is_a: WBPhenotype:0001324 ! cell ionizing radiation response variant [Term] id: WBPhenotype:0001378 name: mitotic chromosome segregation variant def: "Any variation in the cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle compared to control animals." [GO:0000070, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "mitotic chromosome segregation abnormal" NARROW [] is_a: WBPhenotype:0000773 ! chromosome segregation variant [Term] id: WBPhenotype:0001379 name: organism toxic chemical response variant def: "Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557] synonym: "organism toxic chemical response abnormal" NARROW [] is_a: WBPhenotype:0000523 ! chemical response variant [Term] id: WBPhenotype:0001380 name: anoxia hypersensitive def: "Animals respond to anoxic (trace oxygen levels) stress after a shorter exposure time compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000464 ! oxygen response variant [Term] id: WBPhenotype:0001381 name: anoxia resistant def: "Animals fail to respond to trace amounts of oxygen that elicit a response in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000464 ! oxygen response variant [Term] id: WBPhenotype:0001382 name: protein modification variant def: "Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GO:0006464, WB:WBPerson2021] synonym: "protein modification abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein expression variant [Term] id: WBPhenotype:0001383 name: protein methylation variant def: "Variations in the processes that incorporate methyl groups to one or more amino acids within a protein, compared to control." [GO:0006479, WB:WBPerson2021] synonym: "protein methylation abnormal" NARROW [] is_a: WBPhenotype:0001382 ! protein modification variant [Term] id: WBPhenotype:0001384 name: fertility reduced def: "Animals exhibit a reduction in the production of new individuals that contain some portion of their genetic material inherited from that organism as a result of defective gametes." [GO:0000003, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000145 ! fertility variant [Term] id: WBPhenotype:0001385 name: precocious oogenesis def: "Relatively unspecialized germ cells prematurely acquire the specialized properties of mature oocytes." [WB:WBPaper00001475, WB:WBPaper00028819, WB:WBPerson2021] is_a: WBPhenotype:0000186 ! oogenesis variant is_a: WBPhenotype:0000439 ! precocious heterochronic variations [Term] id: WBPhenotype:0001386 name: fertilization defective hermaphrodite def: "Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) in adult hermaphrodites during sexual reproduction." [WB:WBPerson2021] is_a: WBPhenotype:0000983 ! fertilization defective [Term] id: WBPhenotype:0001387 name: fertilization defect male def: "Failure of male-derived sperm to fuse with an oocyte during sexual reproduction." [WB:WBPaper00033007, WB:WBPerson2021] is_a: WBPhenotype:0000983 ! fertilization defective [Term] id: WBPhenotype:0001388 name: organism hypersensitive gamma irradiation def: "Organisms respond to a lower dosage of gamma rays or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000497 ! organism gamma ray response variant is_a: WBPhenotype:0000711 ! organism hypersensitive ionizing radiation [Term] id: WBPhenotype:0001389 name: cell gamma ray resistant def: "Cells fail to respond to the dosage of gamma irradiation that elicits a response in control animals. Alternatively, cells require longer exposure times to gamma irradiation to mimic the response observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001326 ! cell gamma ray response variant [Term] id: WBPhenotype:0001390 name: cell UV hypersensitive def: "Cells respond to a lower dosage of UV or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000100 ! cell UV response variant [Term] id: WBPhenotype:0001391 name: gamma ray induced apoptosis increased def: "Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000183 ! apoptosis increased is_a: WBPhenotype:0001326 ! cell gamma ray response variant [Term] id: WBPhenotype:0001392 name: cell cycle arrest def: "Cells of the animals cease during one of its replicative phases (G1, S, G2, M)." [GO:0007050, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0001995 ! cell cycle progression variant [Term] id: WBPhenotype:0001393 name: cell acidification variant def: "Variations in the processes that reduce the internal pH of a cell (measured by the concentration of the hydrogen ion), compared to control." [GO:0045851, WB:WBPerson2021] synonym: "cell acidification abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0001394 name: cell acidification defective def: "Animals lack the capacity to reduce the internal pH of a cell." [GO:0045851, WB:WBPerson2021] synonym: "no pumping" RELATED [] is_a: WBPhenotype:0001393 ! cell acidification variant [Term] id: WBPhenotype:0001395 name: body vacuole def: "Vacuoles accumulate in the body. A vacuole is a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GO:0005776, WB:WBPerson557] is_a: WBPhenotype:0000072 ! body morphology variant [Term] id: WBPhenotype:0001396 name: pumping absent def: "Animals completely lack any pharyngeal pumping motion." [WB:WBPaper00001894, WB:WBPerson2021] is_a: WBPhenotype:0001006 ! pharyngeal pumping rate variant [Term] id: WBPhenotype:0001397 name: necrotic cell death increased def: "Animals exhibit an increase in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control." [GO:0070265, WB:WBPerson712] is_a: WBPhenotype:0000415 ! necrotic cell death variant [Term] id: WBPhenotype:0001398 name: neurite morphology variant def: "Animals display variations in the structure, organization of components, or spatial pattern of any projection stemming from a neuronal cell, compared to that observed in control animals." [GO:0043005, WB:WBPaper00028886, WB:WBPerson712] synonym: "neurite morphology abnormal" NARROW [] is_a: WBPhenotype:0000905 ! neuron morphology variant [Term] id: WBPhenotype:0001399 name: cell membrane morphology variant def: "Any variation in the structure, form or composition of the semipermeable lipid bilayer that creates a boundary between the interior and exterior environment for cells, cellular organelles and tissues, within an organism compared to control." [GO:0005886, WB:WBPerson2021, WB:WBPerson557] synonym: "cell membrane morphology abnormal" NARROW [] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0001400 name: level of protein expression variant def: "Animals exhibit variations in the measured expression of a protein compared to that observed in control animals." [WB:WBPerson2021] synonym: "level of protein expression abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein expression variant [Term] id: WBPhenotype:0001401 name: mitochondria morphology variant def: "The morphological appearance of mitochondria is varied compared to control animals." [WB:cab] synonym: "mitochondria morphology abnormal" NARROW [] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0001402 name: connected mitochondria def: "Mitochondria are interconnected by thin tubules of mitochondrial inner or outer membrane." [GO:0007006, WB:WBPaper00032231, WB:WBPerson712] is_a: WBPhenotype:0001401 ! mitochondria morphology variant [Term] id: WBPhenotype:0001403 name: antibody subcellular localization variant def: "Any variation in the placement of a protein, as detected by antibody staining, within in a cell or cellular compartment compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "antibody subcellular localization abnormal" NARROW [] is_a: WBPhenotype:0000424 ! antibody staining variant [Term] id: WBPhenotype:0001404 name: ectopic expression antibody def: "Any variation that results in the detection of protein expression in cells/tissues through antibody staining, that is otherwise not observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000424 ! antibody staining variant [Term] id: WBPhenotype:0001405 name: protein aggregation variant def: "Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021] synonym: "protein aggregation abnormal" NARROW [] is_a: WBPhenotype:0001370 ! protein protein interaction variant [Term] id: WBPhenotype:0001406 name: protein expression reduced male def: "Variations that result in a decrease in protein expression in male animals compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein expression reduced [Term] id: WBPhenotype:0001407 name: protein expression reduced cell specific def: "Variations that result in a decrease in protein expression in specific cells compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein expression reduced [Term] id: WBPhenotype:0001408 name: pattern protein expression variant def: "Any variation in the cellular or subcellular distribution of a protein compared to that observed in control animals." [WB:WBPerson2021] synonym: "pattern protein expression abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein expression variant [Term] id: WBPhenotype:0001409 name: protein expression ectopic def: "Any variation that results in the cellular expression of a protein in cells/tissues, that is otherwise not observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001408 ! pattern protein expression variant [Term] id: WBPhenotype:0001410 name: protein expression absent def: "Animals fail to express a given protein or class of proteins." [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein expression reduced [Term] id: WBPhenotype:0001411 name: cuticle carbohydrate surface variant def: "Animals exhibit an altered display of glycosylated proteins or lipids or altered access to glycosylated moieties along their surface from that observed in control animals of the same developmental stage. In C. elegans, variations in surface accessible glycosylated species are often revealed by altered lectin-binding from that observed in control animals." [WB:WBPaper00001576, WB:WBPerson712] synonym: "cuticle carbohydrate surface abnormal" NARROW [] synonym: "ectopic lectin binding" RELATED [] synonym: "Srf" NARROW [] is_a: WBPhenotype:0001210 ! pericellular component physiology variant [Term] id: WBPhenotype:0001412 name: alae morphology variant def: "Animals exhibit variations in the organization of the longitudinal ridges on the cuticle along the length of the animal, from that observed for control animals of the same developmental stage." [WB:WBPaper00000465, WB:WBPaper00031415, WB:WBPerson712] synonym: "alae morphology abnormal" NARROW [] is_a: WBPhenotype:0000948 ! cuticle morphology variant [Term] id: WBPhenotype:0001413 name: bacterially unswollen def: "Animals do not exhibit tail-swelling in response to infection by a bacterial pathogen (such as Microbacterium nematophilum) compared to control." [WB:cab, WB:WBPaper00026735] synonym: "Bus" BROAD [] is_a: WBPhenotype:0000073 ! tail morphology variant is_a: WBPhenotype:0001014 ! pathogen resistance increased [Term] id: WBPhenotype:0001414 name: male mating defective def: "Males exhibit defects in the specific actions or reactions that are associated with reproduction." [GO:0060179, WB:WBPerson2021, WB:WBPerson557] synonym: "Cod" BROAD [] is_a: WBPhenotype:0000648 ! male mating variant [Term] id: WBPhenotype:0001415 name: pathogen adherence variant def: "Animals exhibit variations that result in pathogens not being able to adhere to the surface compared to control." [WB:cab, WB:WBPaper00026735] synonym: "pathogen adherence abnormal" NARROW [] is_a: WBPhenotype:0001012 ! organism pathogen response variant [Term] id: WBPhenotype:0001416 name: pathogen adherence defect def: "Pathogens are unable to adhere/colonize the surface of host animals. This defect is often associated with changes in cuticle surface properties of the host." [WB:WBPaper00028877, WB:WBPerson2021] is_a: WBPhenotype:0001014 ! pathogen resistance increased is_a: WBPhenotype:0001415 ! pathogen adherence variant [Term] id: WBPhenotype:0001417 name: organism dessication response variant def: "Any variation in the state or activity of an organism in response to extreme dryness or drought-like conditions, compared to control ." [GO:0009819, WB:WBPerson2021] synonym: "organism dessication response abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0001418 name: organism hypersensitive dessication def: "Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001417 ! organism dessication response variant [Term] id: WBPhenotype:0001419 name: emetine hypersensitive def: "Animals respond to emetine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0001420 name: biofilm absent head def: "Animals can move thorough a lawn of bacterially produced biofilm without accumulating an enormous amount of biofilm on its nose. When C. elegans is exposed to certain bacteria (e.g., Y. pestis), a biofilm accumulates on a worm's head. The presence of this biofilm inhibits feeding by the worm, and thereby prevents growth." [WB:cab, WB:WBPaper00005238] synonym: "Bah" BROAD [] is_a: WBPhenotype:0001415 ! pathogen adherence variant [Term] id: WBPhenotype:0001421 name: endocytic transport variant def: "Animals exhibit variations in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks material to different compartments of the cell or back to the plasma membrane for recycling compared to control." [GO:0016197, WB:WBPaper00031894, WB:WBPerson712] synonym: "endocytic transport abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0001422 name: endocytic transport defect def: "Animals exhibit defects in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks material to different compartments of the cell or back to the plasma membrane for recycling." [GO:0016197, WB:WBPerson557] is_a: WBPhenotype:0001421 ! endocytic transport variant [Term] id: WBPhenotype:0001423 name: coelomocyte physiology variant def: "Animals exhibit variations in any physical or chemical process required for the coelomocyte to carry out its normal functions or activities, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "coelomocyte physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0001424 name: oocyte physiology variant def: "Animals exhibit variations in any physical or chemical process required for the oocyte to carry out its normal functions or activities, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "oocyte physiology abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0001425 name: receptor mediated endocytosis defective def: "Animals exhibit defects in the cell-mediated uptake of external materials via receptor activity. Receptor-mediated endocytosis ensures specificity of transport and generally occurs via clathrin-coated pits and vesicles. In C. elegans, this is often judged by the lack of yolk uptake in oocytes." [GO:0006898, pmid:16042554, WB:cab, WB:WBPerson2021] comment: Possible XP = GO:0006898. synonym: "Rme" RELATED [] is_a: WBPhenotype:0001422 ! endocytic transport defect is_a: WBPhenotype:0001424 ! oocyte physiology variant [Term] id: WBPhenotype:0001426 name: coelomocyte uptake defective def: "Fluid-phase endocytosis by coelomocytes is less frequent or efficient compared to control." [pmid:16042554, WB:cab] synonym: "Cup" RELATED [] is_a: WBPhenotype:0001422 ! endocytic transport defect is_a: WBPhenotype:0001423 ! coelomocyte physiology variant [Term] id: WBPhenotype:0001427 name: cytoplasmic appearance variant def: "Animals exhibit variations in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "cytoplasmic appearance abnormal" NARROW [] is_a: WBPhenotype:0010002 ! cell organization biogenesis variant [Term] id: WBPhenotype:0001428 name: intestinal vacuole def: "Vacuoles accumulate in the intestine." [WB:WBPaper00004718, WB:WBPaper00031894, WB:WBPerson712] is_a: WBPhenotype:0000710 ! intestinal morphology variant [Term] id: WBPhenotype:0001429 name: granules cytoplasm def: "Animals accumulate an excess of vesicle-like structures in cells." [pmid:17203072, WB:cab] is_a: WBPhenotype:0001427 ! cytoplasmic appearance variant [Term] id: WBPhenotype:0001430 name: lysosome organization biogenesis variant def: "Variations in the processes that are carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome, compared to control." [GO:0007040, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "lysosome organization biogenesis abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0001431 name: pointed tail tip male def: "Male tails fail to undergo tip retraction thereby forming a 'leptoderan' or 'pointed' adult tail." [WB:WBPerson2021, WB:WBPerson557] synonym: "Lep" BROAD [] synonym: "leptoderan tail" RELATED [] synonym: "male tail spike" EXACT [] is_a: WBPhenotype:0000070 ! male tail morphology variant [Term] id: WBPhenotype:0001432 name: over retracted male tail def: " Adult males exhibit a truncated tail, often without a fan or have well-developed fans but squarish, truncated back ends compared to control. In C. elegans this is due to precocious male tail tip retraction beginning in the early L3 stage (normally retraction begins in the L4 stage). Condition can be lethal if the function of the anus is affected." [pmid:16806150, WB:cab] synonym: "Ore" BROAD [] is_a: WBPhenotype:0000070 ! male tail morphology variant is_a: WBPhenotype:0001297 ! male tail development variant [Term] id: WBPhenotype:0001433 name: precocious cell fusion def: "Two or more individual cells form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes at an earlier stage of development compared to comparable cells in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000165 ! cell fusion variant is_a: WBPhenotype:0000439 ! precocious heterochronic variations [Term] id: WBPhenotype:0001434 name: chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific chemical concentration gradient compared to control. Directed movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GO:0006935, WB:cab] synonym: "Che" RELATED [] synonym: "chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001040 ! chemosensory response variant [Term] id: WBPhenotype:0001435 name: ammonium chloride chemotaxis defective def: "Failure in directed movement in response to ammonium chloride compared to control. In C. elegans, NH4Cl is an attractant. NH4Cl has also subsequently been used to assay for Cl- attraction in C. elegans." [WB:WBPaper00002087, WB:WBPaper00004609, WB:WBPaper00026812] synonym: "chloride chemotaxis defective" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective is_a: WBPhenotype:0001460 ! ammonium chloride chemotaxis variant [Term] id: WBPhenotype:0001436 name: nose touch hypersensitive def: "Animals tend to initiate a response more often, compared to control, after nose-on collisions with an object. In C. elegans, animals initiate backwards movement in response to nose touch." [WB:WBPaper00028963, WB:WBPerson557] is_a: WBPhenotype:0004026 ! nose touch variant [Term] id: WBPhenotype:0001437 name: octanol chemotaxis hypersensitive def: "Animals execute a response, via directed movement to octanol at a lower concentration or shorter exposure time compared to control. In C. elegans, animals avoid octanol." [WB:WBPaper00028963] is_a: WBPhenotype:0001452 ! octanol chemotaxis variant [Term] id: WBPhenotype:0001438 name: odorant positive chemotaxis defective def: "Animals fail to move towards attractive volatile organic molecules. In C. elegans, these compounds are sensed by the AWA and AWC neurons." [WB:WBPerson2021] is_a: WBPhenotype:0000015 ! positive chemotaxis defective is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant [Term] id: WBPhenotype:0001439 name: anion positive chemotaxis defective def: "Animals fail to move towards attractive anions." [WB:WBPaper00002033, WB:WBPaper00028386] is_a: WBPhenotype:0001052 ! anion positive chemotaxis variant is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective [Term] id: WBPhenotype:0001440 name: cation positive chemotaxis defective def: "Animals fail to move towards attractive cations." [WB:WBPaper00004609] is_a: WBPhenotype:0001051 ! cation positive chemotaxis variant is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective [Term] id: WBPhenotype:0001441 name: aqueous positive chemotaxis defective def: "Animals fail to move towards attractive water-soluble chemicals." [WB:WBPerson2021] synonym: "water soluble positive chemotaxis abnormal" RELATED [] is_a: WBPhenotype:0000015 ! positive chemotaxis defective is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant [Term] id: WBPhenotype:0001442 name: sodium acetate chemotaxis defective def: "Failure in directed movement in response to sodium acetate. In C. elegans, sodium acetate is an attractant. Sodium acetate has also subsequently been used to assay for Na+ attraction in C. elegans." [WB:WBPaper00000650, WB:WBPaper00004609, WB:WBPaper00006394] synonym: "sodium chemotaxis defective" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective is_a: WBPhenotype:0001461 ! sodium acetate chemotaxis variant [Term] id: WBPhenotype:0001443 name: aqueous chemosensory response variant def: "Animals exhibit variations in response to water-soluble chemicals, compared to control." [WB:cab] synonym: "aqueous chemosensory response abnormal" NARROW [] synonym: "water soluble chemosensory response abnormal" RELATED [] is_a: WBPhenotype:0001040 ! chemosensory response variant [Term] id: WBPhenotype:0001444 name: aqueous adaptation defective def: "Animals do not exhibit characteristic desensitization to a water-soluble chemo-attractive signal in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150] synonym: "aqueous adaptation abnormal" NARROW [] synonym: "gustatory plasticity abnormal" RELATED [] synonym: "water soluble adaptation abnormal" RELATED [] is_a: WBPhenotype:0001443 ! aqueous chemosensory response variant [Term] id: WBPhenotype:0001445 name: sodium acetate adaptation defective def: "Animals do not exhibit characteristic chemoattractive desensitization to sodium acetate in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150] synonym: "sodium acetate adaptation abnormal" NARROW [] is_a: WBPhenotype:0001444 ! aqueous adaptation defective [Term] id: WBPhenotype:0001446 name: sodium chloride adaptation defective def: "Animals do not exhibit characteristic chemoattractive desensitization to sodium chloride in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150] synonym: "sodium chloride adaptation abnormal" NARROW [] is_a: WBPhenotype:0001444 ! aqueous adaptation defective [Term] id: WBPhenotype:0001447 name: ammonium chloride adaptation defective def: "Animals do not exhibit characteristic chemoattractive desensitization to ammonium chloride in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150] synonym: "ammonium chloride adaptation abnormal" NARROW [] is_a: WBPhenotype:0001444 ! aqueous adaptation defective [Term] id: WBPhenotype:0001448 name: odorant negative chemotaxis defective def: "Animals fail to move away from repellant volatile organic chemicals." [WB:WBPerson2021] synonym: "volatile negative chemotaxis defective" RELATED [] is_a: WBPhenotype:0001455 ! odorant negative chemotaxis variant [Term] id: WBPhenotype:0001449 name: aqueous negative chemotaxis defective def: "Animals fail to move away from repellent water soluble chemicals." [WB:WBPerson2021] synonym: "water soluble chemotaxis defective" RELATED [] is_a: WBPhenotype:0001450 ! aqueous negative chemotaxis variant [Term] id: WBPhenotype:0001450 name: aqueous negative chemotaxis variant def: "Animals exhibit variations through directed movement, in response to repellant water soluble chemicals, compared to control." [WB:WBPaper00006481] synonym: "aqueous negative chemotaxis abnormal" NARROW [] synonym: "water soluble chemotaxis abnormal" RELATED [] is_a: WBPhenotype:0000481 ! negative chemotaxis variant is_a: WBPhenotype:0001443 ! aqueous chemosensory response variant [Term] id: WBPhenotype:0001451 name: garlic chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of garlic compared to control. In C. elegans, garlic is typically a repellant." [WB:WBPaper00002135, WB:WBPaper00006481, WB:WBPerson557] synonym: "garlic chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001450 ! aqueous negative chemotaxis variant [Term] id: WBPhenotype:0001452 name: octanol chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of octanol. In C. elegans, octanol is typically a repellant." [WB:WBPerson557] synonym: "octanol chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001455 ! odorant negative chemotaxis variant [Term] id: WBPhenotype:0001453 name: high sodium chloride concentration osmotic avoidance variant def: "Animals exhibit variations in their avoidance response to high concentrations of sodium chloride solution compared to control." [WB:WBPerson2021] synonym: "high sodium chloride concentration osmotic avoidance abnormal" NARROW [] is_a: WBPhenotype:0000249 ! osmotic avoidance defective [Term] id: WBPhenotype:0001454 name: quinine chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of the bitter tastant quinine, a water soluble molecule. In C. elegans, quinine is typically a repellant." [WB:WBPaper00002135, WB:WBPaper00027118, WB:WBPaper00035961, WB:WBPerson557, WB:WBPerson712] synonym: "quinine chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001939 ! bitter tastant response variant [Term] id: WBPhenotype:0001455 name: odorant negative chemotaxis variant def: "Animals exhibit variations through directed movement, in response to repellant volatile organic chemicals, compared to control." [WB:WBPaper00001786] synonym: "odorant negative chemotaxis abnormal" NARROW [] synonym: "volatile negative chemotaxis abnormal" RELATED [] is_a: WBPhenotype:0000481 ! negative chemotaxis variant is_a: WBPhenotype:0001048 ! odorant chemosensory response variant [Term] id: WBPhenotype:0001456 name: nonanone chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of nonanone. In C. elegans, nonanone is typically a repellant." [WB:WBPerson2021, WB:WBPerson557] synonym: "nonanone chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001455 ! odorant negative chemotaxis variant [Term] id: WBPhenotype:0001457 name: bromide chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of bromide. In C. elegans, bromide is typically an attractant." [WB:WBPaper00000387, WB:WBPerson557] synonym: "bromide chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001052 ! anion positive chemotaxis variant [Term] id: WBPhenotype:0001458 name: chloride chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of chloride." [WB:WBPaper00000387] synonym: "ammonium chloride chemotaxis abnormal" RELATED [WB:WBPerson2021] synonym: "chloride chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001052 ! anion positive chemotaxis variant [Term] id: WBPhenotype:0001459 name: iodide chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of iodide." [WB:WBPaper00000387] synonym: "iodide chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001052 ! anion positive chemotaxis variant [Term] id: WBPhenotype:0001460 name: ammonium chloride chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of ammonium chloride. In C. elegans, at specific concentrations, ammonium chloride is an attractant. NH4Cl has also been used to assay for Cl- attraction." [WB:WBPaper00000387, WB:WBPaper00004609, WB:WBPaper00026812] synonym: "ammonium chloride chemotaxis abnormal" NARROW [] synonym: "chloride chemotaxis abnormal" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant [Term] id: WBPhenotype:0001461 name: sodium acetate chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium acetate. In C. elegans, at specific concentrations, sodium acetate is an attractant. Sodium acetate has also been used to assay for Na+ attraction." [WB:WBPaper00000387, WB:WBPaper00000650, WB:WBPaper00004609)] synonym: " sodium chemotaxis abnormal" RELATED [WB:WBPerson2021] synonym: "sodium acetate chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant [Term] id: WBPhenotype:0001462 name: sodium chloride chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium chloride. In C. elegans, at specific concentrations, sodium chloride is an attractant." [WB:WBPaper00000387] synonym: "sodium chloride chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous positive chemotaxis variant [Term] id: WBPhenotype:0001463 name: cAMP chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of cAMP." [GO:0043327, WB:WBPaper00000387] synonym: "cAMP chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001053 ! cyclic nucleotide positive chemotaxis variant [Term] id: WBPhenotype:0001464 name: cGMP chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of cGMP." [WB:WBPaper00000387] synonym: "cGMP chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001053 ! cyclic nucleotide positive chemotaxis variant [Term] id: WBPhenotype:0001465 name: acetone chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of acetone. In C. elegans, at specific concentrations, acetone is an attractant." [WB:WBPerson2021] synonym: "acetone chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant [Term] id: WBPhenotype:0001466 name: AWA odorant chemotaxis variant def: "Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWA sensory neuron in control animals." [WB:WBPerson2021] synonym: "AWA odorant chemotaxis abnormal" NARROW [] synonym: "AWA volatile chemotaxis abnormal" RELATED [] is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant [Term] id: WBPhenotype:0001467 name: AWC odorant chemotaxis variant def: "Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWC sensory neuron in control animals." [WB:WBPerson2021] synonym: "AWC odorant chemotaxis abnormal" NARROW [] synonym: "AWC volatile chemotaxis abnormal" RELATED [] is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant [Term] id: WBPhenotype:0001468 name: benzaldehyde chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of benzaldehyde. In C. elegans, at specific concentrations, benzaldehyde is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "benzaldehyde chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001467 ! AWC odorant chemotaxis variant [Term] id: WBPhenotype:0001469 name: butanone chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of butanone. In C. elegans, at specific concentrations, butanone is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "butanone chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001467 ! AWC odorant chemotaxis variant [Term] id: WBPhenotype:0001470 name: diacetyl chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of diacetyl. In C. elegans, at specific concentrations, diacetyl is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "diacetyl chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001466 ! AWA odorant chemotaxis variant [Term] id: WBPhenotype:0001471 name: hexanol chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of hexanol. In C. elegans, at specific concentrations, hexanol is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "hexanol chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant [Term] id: WBPhenotype:0001472 name: isoamyl alcohol chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of isoamyl alcohol. In C. elegans, at specific concentrations, isoamyl alcohol is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "isoamyl alcohol chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001467 ! AWC odorant chemotaxis variant [Term] id: WBPhenotype:0001473 name: pentanol chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanol. In C. elegans, at specific concentrations, pentanol is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "pentanol chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant [Term] id: WBPhenotype:0001474 name: pyrazine chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of pyrazine. In C. elegans, at specific concentrations, pyrazine is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "pyrazine chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001466 ! AWA odorant chemotaxis variant [Term] id: WBPhenotype:0001475 name: trimethylthiazole chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of trimethylthiazole. In C. elegans, at specific concentrations, trimethylthiazole is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "trimethylthiazole chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant [Term] id: WBPhenotype:0001476 name: anterior body contraction variant def: "Any variation in the defecation motor program that involves the contraction of the anterior body wall muscles compared to control." [WB:WBPaper00001937, WB:WBPerson2021, WB:WBPerson557] synonym: "anterior body contraction abnormal" NARROW [] is_a: WBPhenotype:0000210 ! defecation contraction variant [Term] id: WBPhenotype:0001477 name: anterograde transport variant def: "Any variation in the directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons, compared to control." [GO:0008089, WB:WBPerson2021, WB:WBPerson557] synonym: "anterograde transport abnormal" NARROW [] is_a: WBPhenotype:0000853 ! intraflagellar transport variant [Term] id: WBPhenotype:0001478 name: body elongation variant def: "Any variation in the elongation of embryonic epidermal cells compared to control. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm." [WB:WBPerson2021, WB:WBPerson557] synonym: "body elongation abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0001479 name: dauer pheromone sensation variant def: "Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that induces dauer formation in control animals." [GO:0043695, WB:WBPerson2021, WB:WBPerson557] synonym: "dauer pheromone sensation abnormal" NARROW [] is_a: WBPhenotype:0000132 ! pheromone induced dauer formation variant is_a: WBPhenotype:0000305 ! pheromone sensation variant is_a: WBPhenotype:0001847 ! sterol induced dauer formation variant [Term] id: WBPhenotype:0001480 name: grinder relaxation variant def: "Variations in the rhythmic relaxations of the a highly specialized cuticle region of the pharynx inside the lumen of the second bulb, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "grinder relaxation abnormal" NARROW [] is_a: WBPhenotype:0000336 ! terminal bulb relaxation variant [Term] id: WBPhenotype:0001481 name: thrashing increased def: "The number of body thrashes within an aqueous environment in a given period of time is increased, compared with control worms." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001700 ! swimming variant [Term] id: WBPhenotype:0001482 name: frequency body bend reduced def: "Animals exhibit a reduction in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson557, WB:WBPerson712] synonym: "bending frequency reduced" RELATED [] is_a: WBPhenotype:0001213 ! locomotion reduced is_a: WBPhenotype:0004023 ! frequency of body bend variant [Term] id: WBPhenotype:0001483 name: late stage egg laid def: "The eggs being deposited by adults are of a later developmental stage, compared to control. In C. elegans, this is likely to be a consequence of delayed active egg-laying periods." [WB:WBPaper00004310, WB:WBPerson2021] is_a: WBPhenotype:0000438 ! retarded heterochronic variations is_a: WBPhenotype:0000545 ! egg retention [Term] id: WBPhenotype:0001484 name: ammonium acetate chemotaxis defective def: "Animals fail to execute directed movement in response to ammonium acetate. In C. elegans, ammonium acetate is an attractant." [WB:WBPaper00004136] is_a: WBPhenotype:0000265 ! odorant positive chemotaxis variant is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective [Term] id: WBPhenotype:0001485 name: ER stress response variant def: "Animals exhibit variations in their response to the presence of unfolded proteins in the endoplasmic reticulum (ER) or to other ER-related stressors compared to control." [GO:0030968] synonym: "endoplasmic reticulum stress response abnormal" RELATED [] synonym: "ER stress response abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell stress response variant [Term] id: WBPhenotype:0001486 name: unfolded protein accumulation def: "Animals accumulate unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria." [WB:WBPerson557] is_a: WBPhenotype:0000142 ! cell stress response variant is_a: WBPhenotype:0001644 ! protein metabolism variant [Term] id: WBPhenotype:0001487 name: male spicule development variant def: "Animals exhibit variations in the development of the male elongated sclerotized structures covered by a hardened layer of cuticle in the tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control." [WB:cab, WB:WBPerson363] synonym: "male spicule development abnormal" NARROW [] is_a: WBPhenotype:0000430 ! male copulatory structure development variant [Term] id: WBPhenotype:0001488 name: gubernaculum development variant def: "Animals exhibit variations in the development of the sclerotic cuticle that forms the roof of the proctodeum (gubernaculum) compared to control." [WB:cab, WB:WBPerson363] synonym: "gubernaculum development abnormal" NARROW [] is_a: WBPhenotype:0001367 ! proctodeum development variant [Term] id: WBPhenotype:0001489 name: gubernaculum morphology variant def: "Animals exhibit variations in the structure or composition of the sclerotic cuticle that forms the roof of the proctodeum, from that observed in control animals." [WB:cab, WB:WBPaper00027278, WB:WBPerson363, WB:WBPerson712] synonym: "gubernaculum morphology abnormal" NARROW [] is_a: WBPhenotype:0001359 ! proctodeum morphology variant [Term] id: WBPhenotype:0001492 name: no back end def: "Animals lack a properly developed posterior region compared to control. In C. elegans, mutants exhibit a severely deformed posterior region with a variable knob-like shape; accompanied by arrest at about the time of hatching with fairly normal pharyngeal and anterior development. Most mutants arrest as L1 larvae, and 5% do not hatch." [WB:cab, WB:cgc4499] synonym: "Nob" BROAD [] is_a: WBPhenotype:0000081 ! L1 arrest is_a: WBPhenotype:0000793 ! posterior body morphology variant is_a: WBPhenotype:0000800 ! posterior region development variant is_a: WBPhenotype:0000867 ! embryonic arrest [Term] id: WBPhenotype:0001493 name: VPC cell division precocious def: "VPCs (vulval precursor cells) divide at an earlier stage of development compared to control animals; in C. elegans, VPCs divide in the mid-L3 stage to generate the 22 cells that comprise the vulva." [pmid:16300753, WB:cab] is_a: WBPhenotype:0000345 ! VPC cell division variant is_a: WBPhenotype:0001495 ! cell division precocious [Term] id: WBPhenotype:0001494 name: distal tip cell migration precocious def: "DTCs migrate at an earlier stage of development, compared to control." [pmid:16300753, WB:cab] is_a: WBPhenotype:0000195 ! distal tip cell migration variant is_a: WBPhenotype:0000439 ! precocious heterochronic variations [Term] id: WBPhenotype:0001495 name: cell division precocious def: "Cells divide at an earlier stage of development compared to control animals." [WB:cab] is_a: WBPhenotype:0000439 ! precocious heterochronic variations is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0001496 name: metaphase to anaphase transition defect def: "Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle." [GO:0007091, WB:WBPerson712] synonym: "Mat" RELATED [] is_a: WBPhenotype:0000740 ! cell cycle variant [Term] id: WBPhenotype:0001497 name: mitotic metaphase to anaphase transition defect def: "Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids separate and migrate towards the poles of the spindle." [GO:0007091, WB:WBPerson712] is_a: WBPhenotype:0001496 ! metaphase to anaphase transition defect [Term] id: WBPhenotype:0001498 name: sperm pseudopod physiology variant def: "Animals exhibit variations in any physical or chemical process required for the pseudopod of the sperm to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557] synonym: "sperm pseudopod physiology abnormal" NARROW [] is_a: WBPhenotype:0000987 ! germ cell physiology variant [Term] id: WBPhenotype:0001499 name: meiotic chromosome segregation variant def: "Variations in the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle, compared to control." [GO:0045132, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "meiotic chromosome segregation abnormal" NARROW [] is_a: WBPhenotype:0000773 ! chromosome segregation variant [Term] id: WBPhenotype:0001500 name: pentanedione chemotaxis variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanedione." [WB:cab, WB:cgc2931] synonym: "pentanedione chemotaxis abnormal" NARROW [] is_a: WBPhenotype:0001467 ! AWC odorant chemotaxis variant [Term] id: WBPhenotype:0001501 name: odorant discrimination defective def: "Animals fail to discriminate between distinct odorants." [WB:cab] synonym: "odorant discrimination abnormal" NARROW [] is_a: WBPhenotype:0001048 ! odorant chemosensory response variant [Term] id: WBPhenotype:0001502 name: chemical resistant def: "Animals fail to respond to the concentration of a specific chemical that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000523 ! chemical response variant [Term] id: WBPhenotype:0001503 name: ventral nerve cord maintenance variant def: "Any variation in the mechanisms used to ensure that axons in the ventral nerve cord maintain their correct positioning after termination of axonal outgrowth and target recognition compared to control." [WB:WBPaper00005064, WB:WBPerson557] synonym: "ventral nerve cord maintenance abnormal" NARROW [] is_a: WBPhenotype:0000515 ! ventral nerve cord development variant [Term] id: WBPhenotype:0001504 name: maternal effect sterile def: "Sterility caused by aberrant maternal components required for normal postembryonic development and/or function of the germ line." [WB:WBPaper00001477] synonym: "Mes" BROAD [] is_a: WBPhenotype:0001037 ! sterile progeny [Term] id: WBPhenotype:0001505 name: spontaneous reversal variant def: "Any variation in the processes that govern spontaneous backward locomotion compared to control." [WB:WBPaper00001311, WB:WBPerson557] synonym: "spontaneous reversal abnormal" NARROW [] is_a: WBPhenotype:0001702 ! directionality variant [Term] id: WBPhenotype:0001506 name: spontaneous reversal rate variant def: "Any variation in the processes that govern the rate at which spontaneous backward locomotion is initiated compared to control. In C. elegans, animals moving forward consistently initiate backward locomotion approximately 10 times per 3 minutes." [WB:WBPaper00001311, WB:WBPaper00026650, WB:WBPerson557] synonym: "spontaneous reversal rate abnormal" NARROW [] is_a: WBPhenotype:0001505 ! spontaneous reversal variant [Term] id: WBPhenotype:0001507 name: Bacillus thuringiensis toxin resistant def: "Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0001508 name: anchor cell fusion defective def: "Any perturbation that disrupts the fusion between the anchor cell and the surrounding utse syncytium. Such variations result in the loss of uterine-vulval connectivity and continuity." [WB:WBPaper00029363, WB:WBPerson2021] synonym: "anchor cell fusion abnormal" NARROW [] is_a: WBPhenotype:0000165 ! cell fusion variant is_a: WBPhenotype:0000283 ! vulva uterus connection defective [Term] id: WBPhenotype:0001509 name: rays missing def: "Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are absent." [WB:WBPerson2021, WB:WBPerson557] synonym: "ray loss" EXACT [] is_a: WBPhenotype:0000199 ! male tail sensory ray development variant is_a: WBPhenotype:0000505 ! male ray morphology variant [Term] id: WBPhenotype:0001510 name: neuronal cell fate specification variant def: "Any variation in the processes that govern acquisition of neuronal cell fates compared to control." [WB:WBPerson2021] synonym: "neuronal cell fate specification abnormal" NARROW [] is_a: WBPhenotype:0000216 ! cell fate specification variant [Term] id: WBPhenotype:0001511 name: linker cell migration variant def: "Variations in the stereotypical migration pattern of the linker cell in a developing male compared to control." [WB:WBPaper00028966, WB:WBPerson2021] synonym: "linker cell migration abnormal" NARROW [] is_a: WBPhenotype:0000594 ! cell migration variant [Term] id: WBPhenotype:0001512 name: loss of left right asymmetry def: "Bilaterally symmetric cell fail to acquire specific left-right asymmetric properties such as L/R specific cell position, cell death or gene expression." [WB:WBPaper00037739, WB:WBPerson2021] synonym: "Lsy" BROAD [] is_a: WBPhenotype:0000216 ! cell fate specification variant [Term] id: WBPhenotype:0001513 name: dense core vesicle exocytosis variant def: "Variations in the process of secretion of a class of membrane-bound vesicles found inside neurons, gland cells, and some epithelial cells in which the central core appears darkly stained when viewed in thin section by electron microscopy, compared to control. Exocytosis occurs via the fusion of the vesicle with the plasma membrane of a cell (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dense core vesicle exocytosis abnormal" NARROW [] is_a: WBPhenotype:0000728 ! exocytosis variant [Term] id: WBPhenotype:0001514 name: synaptic vesicle endocytosis variant def: "Variations in the uptake of a small membrane-bound organelle, filled with neurotransmitter(s) and/or neuropeptides, by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle compared to control(Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "synaptic vesicle endocytosis abnormal" NARROW [] is_a: WBPhenotype:0001422 ! endocytic transport defect is_a: WBPhenotype:0001684 ! synaptic vesicle homeostasis variant [Term] id: WBPhenotype:0001515 name: struts variant def: "Animals exhibit variations in the quantity or patterning of electron-dense columnar structures that join the basal and cortical cuticle layers, from that observed in control animals." [WB:WBPaper00000465, WB:WBPerson712] synonym: "struts abnormal" NARROW [] is_a: WBPhenotype:0000948 ! cuticle morphology variant [Term] id: WBPhenotype:0001516 name: helical cuticle def: "Animals exhibit a helically twisted cuticle. In practice the degree of twisting is measured as the number of helical twists the alae make about anterior/posterior axis of the animal." [WB:WBPaper00000465, WB:WBPerson712] synonym: "cuticle helicity abnormal" NARROW [] is_a: WBPhenotype:0000948 ! cuticle morphology variant [Term] id: WBPhenotype:0001517 name: annulae morphology variant def: "Animals exhibit variations in the circumferential pattern of ridges in the outer cortical layer of the cuticle, compared to that observed in control animals of the same developmental stage." [WB:WBPaper00000465, WB:WBPaper00031415, WB:WBPerson712] synonym: "annulae morphology abnormal" NARROW [] is_a: WBPhenotype:0000948 ! cuticle morphology variant [Term] id: WBPhenotype:0001518 name: biogenic amine physiology variant def: "Any variation in the levels and/or localization of biogenic amines compared to control animals." [WB:WBPaper00000365] synonym: "biogenic amine physiology abnormal" NARROW [] synonym: "FIF" BROAD [] synonym: "Formaldehyde induced fluorescence abnormal " RELATED [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0001519 name: posterior cell migration variant def: "Any variation in the orderly movement of cells along the posterior axis of the animal (abolished, misdirected or incomplete) compared to control." [WB:WBPerson2021] synonym: "abnormal posterior cell migration" NARROW [] is_a: WBPhenotype:0000594 ! cell migration variant [Term] id: WBPhenotype:0001520 name: posterior neuron migration variant def: "Any variation in the orderly movement of neurons along the posterior axis of the animal(abolished, misdirected or incomplete) compared to control." [WB:WBPerson2021] synonym: "abnormal posterior neuron migration" NARROW [] is_a: WBPhenotype:0001140 ! neuron migration variant [Term] id: WBPhenotype:0001521 name: body elongation retracted def: "Embryos retract after the embryonic elongation process." [WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0001522 name: spicules protrude def: "The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) constitutively extend into the external environment through the cloacal opening. In C. elegans males there are two copulatory spicules." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000908 ! cloacal morphology variant [Term] id: WBPhenotype:0001523 name: extracellular matrix variant def: "Any variation in the makeup, density or area of the ECM compared to control." [WB:WBPerson712] synonym: "extracellular matrix abnormal" NARROW [] is_a: WBPhenotype:0000912 ! pericellular component morphology variant [Term] id: WBPhenotype:0001524 name: quiescence variant def: "Exhibition of quiescent behavior under inappropriate conditions and improper recovery from quiescent state. Quiescent behavior is normally coupled with lethargus." [WB:WBPerson2021] synonym: "narcoleptic" RELATED [] synonym: "quiescence abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0001525 name: terminal bulb morphology variant def: "Animals exhibit variations in the structure or organization of the posterior region of the pharynx compared to control." [WB:WBPerson2021] synonym: "terminal bulb morphology abnormal" NARROW [] is_a: WBPhenotype:0000709 ! pharyngeal morphology variant [Term] id: WBPhenotype:0001526 name: ciliated neuron morphology variant def: "Animals exhibit variations in the structure or organization of any one of the specialized sensory receptor cells of the nervous system that compared to control animals. In C. elegans, these specialized cells are characterized as having axoneme containing dendritic projections emanating from their cell body." [WB:WBPaper00000503, WB:WBPaper00029016, WB:WBPerson712] comment: WBbt:0006816. synonym: "ciliated neuron morphology abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum morphology variant [Term] id: WBPhenotype:0001527 name: amphid phasmid sensillum morphology variant def: "Animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head or along the tail, compared to that observed in control animals." [WB:WBPerson712] comment: WBbt:0005391. synonym: "amphid phasmid sensillum morphology abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum morphology variant [Term] id: WBPhenotype:0001528 name: sensillum accessory cell morphology variant def: "Animals exhibit variations in the quantity, structure or organization of any component of the sensillum channel including the sheath and or socket cells, their junctions with each other, channel neurons or surrounding epithelia compared to control." [WB:WBPaper00000932, WB:WBPerson712] synonym: "sensillum accessory cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum morphology variant [Term] id: WBPhenotype:0001529 name: sensilium sheath cell variant def: "Any variation in the form, structure or composition of an interfacial epithelial cell which forms a specialized environment surrounding the ciliated sensory ending(s) of one or more neurons and is often accompanied by a more distal socket cell compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "sensilium sheath cell abnormal" NARROW [] is_a: WBPhenotype:0001528 ! sensillum accessory cell morphology variant [Term] id: WBPhenotype:0001530 name: cephalic sensillum morphology variant def: "Animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake." [WB:WBPaper00000214, WB:WBPaper00000503, WB:WBPaper00000932, WB:WBPerson712] comment: WBbt:0006920. synonym: "cephalic sensillum morphology abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum morphology variant [Term] id: WBPhenotype:0001531 name: labial sensillum morphology variant def: "Animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth." [WB:WBPaper00000214, WB:WBPaper00000938, WB:WBPerson712] synonym: "labial sensillum morphology abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum morphology variant [Term] id: WBPhenotype:0001532 name: inner labial morphology variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2." [WB:WBPaper00000938, WB:WBPerson712] synonym: "inner labial morphology abnormal" NARROW [] is_a: WBPhenotype:0001531 ! labial sensillum morphology variant [Term] id: WBPhenotype:0001533 name: outer labial morphology variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum." [WB:WBPaper00000938, WB:WBPerson712] synonym: "outer labial morphology abnormal" NARROW [] is_a: WBPhenotype:0001531 ! labial sensillum morphology variant [Term] id: WBPhenotype:0001534 name: neuronal ECM variant def: "Any variation in makeup, density or area of the ECM lending structure to neurons compared to control animals. In C. elegans, the neuronal ECM is sometimes referred to as a mantle." [WB:WBPaper00000502, WB:WBPerson712] synonym: "neuronal ECM abnormal" NARROW [] is_a: WBPhenotype:0001523 ! extracellular matrix variant [Term] id: WBPhenotype:0001535 name: deirid sensillum morphology variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC." [WB:WBPaper00000938, WB:WBPaper00029016, WB:WBPerson712] synonym: "deirid sensillum morphology abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum morphology variant [Term] id: WBPhenotype:0001536 name: embryonic cell patterning variant def: "Embryos exhibit variations in the patterning of differentiated cell types, compared to control." [WB:WBPerson557] synonym: "embryonic cell patterning abnormal" NARROW [] is_a: WBPhenotype:0000050 ! embryonic lethal [Term] id: WBPhenotype:0001537 name: mRNA turnover variant def: "Any variation in the ability of cells to monitor the quality of their mRNAs and degrade any transcripts that are poorly or incompletely translated compared to control." [WB:WBPaper00004926] synonym: "mRNA turnover abnormal" NARROW [] is_a: WBPhenotype:0000028 ! RNA processing variant [Term] id: WBPhenotype:0001538 name: mRNA surveillance defective def: "Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia." [WB:WBPaper00001192, WB:WBPaper00004926] synonym: "Smg" NARROW [] is_a: WBPhenotype:0000028 ! RNA processing variant [Term] id: WBPhenotype:0001539 name: dauer induction variant def: "Animals exhibit variations in the entry into the dauer stage when exposed to conditions that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer induction abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer arrest variant [Term] id: WBPhenotype:0001540 name: dauer lifespan variant def: "The life span of dauer-staged animals is either longer or shorter than that observed in control dauer animals." [WB:WBPerson2021] synonym: "dauer lifespan abnormal" NARROW [] is_a: WBPhenotype:0001547 ! dauer metabolism variant [Term] id: WBPhenotype:0001541 name: dauer gonad arrest variant def: "Variations in the execution of the developmentally-regulated cell cycle arrest in the gonad during the dauer stage, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer gonad arrest abnormal" NARROW [] is_a: WBPhenotype:0000637 ! dauer formation variant [Term] id: WBPhenotype:0001542 name: dauer feeding suppressed variant def: "Any variation in the inhibition of feeding which is induced/occurs during the dauer stage compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer feeding suppressed abnormal" NARROW [] is_a: WBPhenotype:0001001 ! dauer behavior variant [Term] id: WBPhenotype:0001543 name: dauer reduced locomotion variant def: "Dauer stage animals exhibit a decrease in self-propelled movement on a solid medium compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer reduced locomotion abnormal" NARROW [] is_a: WBPhenotype:0001001 ! dauer behavior variant [Term] id: WBPhenotype:0001544 name: dauer sensory response variant def: "Variations in the state or activity of a dauer stage organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer sensory response abnormal" NARROW [] is_a: WBPhenotype:0001001 ! dauer behavior variant [Term] id: WBPhenotype:0001545 name: dauer body morphology variant def: "Any variation in the overall structure or appearance of an animal progressing through an alternative larval stage in response to environmental stresses compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer body morphology abnormal" NARROW [] is_a: WBPhenotype:0000934 ! developmental morphology variant [Term] id: WBPhenotype:0001546 name: dauer resistance to harsh conditions variant def: "Variations which lead to the decreased ability of dauer larva to survive at extreme conditions, such as high or low temperatures, the presence of dilute acids, detergents, anesthetics, or even fixatives, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer resistance to harsh conditions abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer arrest variant [Term] id: WBPhenotype:0001547 name: dauer metabolism variant def: "Animals exhibit variations in the chemical reactions and pathways that occur during the dauer life stage, compared to control." [WB:WBPerson2021] synonym: "dauer metabolism abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer arrest variant [Term] id: WBPhenotype:0001548 name: dauer axial ratio variant def: "Any variation in the ratio of the body length to body width in a dauer stage animal, compared to control. Long thin animals will have a high axial ratio." [WB:WBPerson557] synonym: "dauer axial ratio abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer body morphology variant [Term] id: WBPhenotype:0001549 name: dauer gut variant def: "Dauer stage animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer gut abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer body morphology variant [Term] id: WBPhenotype:0001550 name: dauer buccal cavity morphology variant def: "Variations in the form or composition of the cuticle-lined lumenal region which lies just behind the lips at the entrance to the pharyngeal lumen in dauer stage animals compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer buccal cavity morphology abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer body morphology variant [Term] id: WBPhenotype:0001551 name: dauer cuticle variant def: "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) during the dauer larva stage, compared to control animals (Wormatlas). The dauer larval stage is a developmentally arrested larval stage that is specialized for survival under harsh, or otherwise unfavorable environmental conditions." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer cuticle abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer body morphology variant [Term] id: WBPhenotype:0001552 name: dauer pharynx morphology variant def: "Variations in the form or composition of the mouthparts at the anterior end of the digestive tract during the dauer stage, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer pharynx morphology abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer body morphology variant [Term] id: WBPhenotype:0001553 name: dauer excretory gland variant def: "Dauer stage animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer excretory gland abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer body morphology variant [Term] id: WBPhenotype:0001554 name: dauer nose morphology variant def: "Dauer stage animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer nose morphology abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer body morphology variant [Term] id: WBPhenotype:0001555 name: dauer sensory system morphology variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the dauer sensory system, compared to control. The dauer sensory system is used to perceive the physical and chemical environment during the dauer larval stage." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer sensory system morphology abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer body morphology variant [Term] id: WBPhenotype:0001556 name: dauer sensillum variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer sensillum abnormal" NARROW [] is_a: WBPhenotype:0001555 ! dauer sensory system morphology variant [Term] id: WBPhenotype:0001557 name: dauer labial sensillum variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer labial sensillum abnormal" NARROW [] is_a: WBPhenotype:0001556 ! dauer sensillum variant [Term] id: WBPhenotype:0001558 name: dauer amphid sensillum variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head, compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer amphid sensillum abnormal" NARROW [] is_a: WBPhenotype:0001556 ! dauer sensillum variant [Term] id: WBPhenotype:0001559 name: dauer deirid sensillum variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer deirid sensillum abnormal" NARROW [] is_a: WBPhenotype:0001556 ! dauer sensillum variant [Term] id: WBPhenotype:0001560 name: dauer sensory system plug variant synonym: "dauer sensory system plug abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0001561 name: dauer inner labial sensillum variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer inner labial sensillum abnormal" NARROW [] is_a: WBPhenotype:0001557 ! dauer labial sensillum variant [Term] id: WBPhenotype:0001562 name: dauer outer labial sensillum variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer outer labial sensillum abnormal" NARROW [] is_a: WBPhenotype:0001557 ! dauer labial sensillum variant [Term] id: WBPhenotype:0001563 name: dauer cephalic sensillum variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer cephalic sensillum abnormal" NARROW [] is_a: WBPhenotype:0001556 ! dauer sensillum variant [Term] id: WBPhenotype:0001564 name: duration of self fertility variant def: "The window of production of self-fertilized eggs exceeds or does not extend to the same length as control." [WB:WBPaper00002419, WB:WBPerson712] synonym: "duration of self fertility abnormal" NARROW [] is_a: WBPhenotype:0000806 ! hermaphrodite fertility variant [Term] id: WBPhenotype:0001565 name: lysine chemotaxis defective def: "Failure to execute characteristic response to lysine as defined by control animals. In C. elegans, lysine is an attractant." [WB:WBPaper00001481, WB:WBPaper00001786, WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective [Term] id: WBPhenotype:0001566 name: ventral enclosure variant def: "Any variation in the process that regulates the migration of ventral epidermal cells toward the ventral midline (to encase underlying cells in an epithelial monolayer) in developing embryos compared to control." [WB:WBPaper00027244, WB:WBPerson2021] synonym: "ventral enclosure abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0001567 name: nuclei enlarged def: "Nuclei of specific cells are larger compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001028 ! nuclear appearance variant [Term] id: WBPhenotype:0001568 name: mRNA export variant def: "Any variation in the export of mRNA from the cell nucleus compared to control." [WB:WBPaper00005960] synonym: "mRNA export abnormal" NARROW [] is_a: WBPhenotype:0000114 ! mRNA expression variant is_a: WBPhenotype:0001706 ! nuclear export defective [Term] id: WBPhenotype:0001569 name: body wall muscle myosin organization defective def: "The characteristic organization of myosin filaments into discrete A-bands within the muscle cells is disrupted. In C. elegans, myosin filaments no longer appear as continuous longitudinally oriented fibers across the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021] synonym: "body wall muscle myosin organization abnormal" NARROW [] synonym: "body wall muscle thick myofilament organization abnormal" RELATED [WB:WBPerson2021] synonym: "Dim" RELATED [] is_a: WBPhenotype:0000782 ! body wall muscle thick filament variant [Term] id: WBPhenotype:0001570 name: body wall muscle actin organization defective def: "The characteristic organization of actin filaments into I-bands is disrupted. In C. elegans, actin filaments no longer appear as thin continuous longitudinal stripes along the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021] synonym: "body wall muscle actin organization abnormal" NARROW [] synonym: "body wall muscle thin myofilament organization abnormal" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0000781 ! body wall muscle thin filament variant [Term] id: WBPhenotype:0001571 name: body wall muscle cell polarization variant def: "Variations in the accumulation of muscle proteins at membranes where adjacent muscle cells contact each other and the hypodermis compared to control. In C. elegans, during early embryonic body wall muscle development, muscle, basement membrane, and hypodermal components are all colocalized in a continuous linear structure at the site of muscle-hypodermal contact." [WB:WBPaper00001895] synonym: "body wall muscle cell polarization abnormal" NARROW [] is_a: WBPhenotype:0000926 ! body wall muscle morphology variant [Term] id: WBPhenotype:0001572 name: masculinized def: "Animals that are not ordinarily male, exhibit male-specific attributes. In C. elegans, XX animals exhibit male-specific attributes." [WB:WBPaper00000178, WB:WBPaper00001206, WB:WBPerson712] is_a: WBPhenotype:0001022 ! hermaphrodite sexual development variant [Term] id: WBPhenotype:0001573 name: nicotine response variant def: "Animals exhibit variations in the response to the addition of nicotine compared to that observed in control animals. Nicotine is a cholinergic agonist." [WB:WBPerson557] synonym: "nicotine response abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001574 name: ATP levels variant def: "Animals exhibit variations in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology." [WB:WBPerson2021, WB:WBPerson557] synonym: "ATP levels abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0001575 name: ATP levels reduced def: "Animals exhibit a decrease in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001574 ! ATP levels variant [Term] id: WBPhenotype:0001576 name: mitochondria spacing variant def: "Variations in the spatial distribution of the mitochondria within the cell compared to control." [GO:0048311, WB:WBPerson2021, WB:WBPerson557] synonym: "mitochondria spacing abnormal" NARROW [] is_a: WBPhenotype:0001401 ! mitochondria morphology variant [Term] id: WBPhenotype:0001577 name: mitochondria alignment variant def: "Animals exhibit variations in the parallel arrangement of mitochondria within a cell compared to control." [WB:WBPaper00028954] synonym: "mitochondria alignment abnormal" NARROW [] is_a: WBPhenotype:0001401 ! mitochondria morphology variant [Term] id: WBPhenotype:0001578 name: cholinergic agonist resistant def: "Animals fail to respond to the concentration of cholinergic agonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0001579 name: cholinergic agonist hypersensitive def: "Animals respond to a cholinergic agonist at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0001580 name: nuclear envelope breakdown variant def: "Any variation in the progression of the controlled breakdown of the nuclear envelope, compared to control." [GO:0051081, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "nuclear envelope breakdown abnormal" NARROW [] is_a: WBPhenotype:0001138 ! nucleus defective early emb [Term] id: WBPhenotype:0001581 name: X linked gene expression enhanced def: "Levels of transcripts associated with genes on the X chromosome are increased compared to control." [WB:WBPaper00001011, WB:WBPerson712] is_a: WBPhenotype:0000718 ! dosage compensation variant [Term] id: WBPhenotype:0001582 name: X linked gene expression reduced def: "Levels of transcripts associated with genes on the X chromosome are decreased compared to control." [WB:WBPaper00001011, WB:WBPerson712] is_a: WBPhenotype:0000718 ! dosage compensation variant [Term] id: WBPhenotype:0001583 name: XXX progeny def: "Animals segregate progeny with 3 X chromosomes." [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X chromosome nondisjunction [Term] id: WBPhenotype:0001584 name: chromosome alignment variant def: "Any variation in the movement of chromosomes to the spindle equator during mitosis compared to control animals." [GO:0051310, WB:WBPerson557] synonym: "chromosome alignment at metaphase plate abnormal" NARROW [] synonym: "chromosome alignment at metaphase plate variant" NARROW [] synonym: "chromosome congression" RELATED [] is_a: WBPhenotype:0000773 ! chromosome segregation variant [Term] id: WBPhenotype:0001585 name: asymmetric cell division variant def: "Any variation in a cell's ability to divide asymmetrically to produce two daughter cells with different developmental potentials compared to control." [GO:0008356, WB:WBPerson2021, WB:WBPerson557] synonym: "asymmetric cell division abnormal" NARROW [] is_a: WBPhenotype:0001235 ! cell division polarity variant [Term] id: WBPhenotype:0001586 name: multiple anchor cells def: "Animals contain more than one anchor cell. In C. elegans, presumptive ventral uterine cells undergo fate transformation and instead acquire the properties of an anchor cell (often due to defects in lateral signaling)." [WB:WBPaper00001423, WB:WBPerson2021] synonym: "double anchor cell" NARROW [] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0001587 name: actin organization biogenesis variant def: "Animals exhibit variations in the formation and/or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [GO:0030036, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "actin organization biogenesis abnormal" NARROW [] is_a: WBPhenotype:0001345 ! cytoskeleton organization biogenesis variant [Term] id: WBPhenotype:0001588 name: microtubule organization biogenesis variant def: "Animals exhibit variations in the form, structure, composition or arrangement of a robust macromolecular array, composed primarily of tubulin, which forms long extended cytoskeletal elements compared to control (Wormatlas)." [GO:0000226, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. synonym: "microtubule organization biogenesis abnormal" NARROW [] is_a: WBPhenotype:0001345 ! cytoskeleton organization biogenesis variant [Term] id: WBPhenotype:0001589 name: microtubule nucleation variant def: "Any variation that alters the characteristic de novo formation of a microtubule compared to control." [GO:0007020] synonym: "microtubule nucleation abnormal" NARROW [] is_a: WBPhenotype:0001588 ! microtubule organization biogenesis variant [Term] id: WBPhenotype:0001590 name: microtubule depolymerization variant def: "Any variation that alters the characteristic removal of tubulin heterodimers from one or both ends of a microtubule compared to control." [GO:0007019] synonym: "microtubule depolymerization abnormal" NARROW [] is_a: WBPhenotype:0001588 ! microtubule organization biogenesis variant [Term] id: WBPhenotype:0001591 name: microtubule polymerization variant def: "Any variation that alters the characteristic addition of tubulin heterodimers to one or both ends of a microtubule compared to control." [GO:0046785] synonym: "microtubule polymerization abnormal" NARROW [] is_a: WBPhenotype:0001588 ! microtubule organization biogenesis variant [Term] id: WBPhenotype:0001592 name: fainter def: "Alternating periods of stopping and moving; Motion is interrupted by periods of inactivity lasting several seconds." [WB:WBPaper00031286] is_a: WBPhenotype:0001213 ! locomotion reduced [Term] id: WBPhenotype:0001593 name: transgene silencing variant def: "Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, compared to control. In C. elegans this silencing occurs only in the germline." [WB:WBPaper00005399, WB:WBPerson2021, WB:WBPerson557] synonym: "transgene silencing abnormal" NARROW [] is_a: WBPhenotype:0002063 ! maintenance of gene silencing variant [Term] id: WBPhenotype:0001594 name: germline transgene silencing variant def: "Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the germline, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "germline transgene silencing abnormal" NARROW [] is_a: WBPhenotype:0001593 ! transgene silencing variant [Term] id: WBPhenotype:0001595 name: somatic transgene silencing variant def: "Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the soma, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "somatic transgene silencing abnormal" NARROW [] is_a: WBPhenotype:0001593 ! transgene silencing variant [Term] id: WBPhenotype:0001596 name: tail bobbed def: "Swelling of the tail hypodermis resulting in a prematurely-truncated and thickened appearance of the tail. In C. elegans, this is usually applies to hermaphrodites." [WB:WBPaper00024194, WB:WBPerson712] is_a: WBPhenotype:0000073 ! tail morphology variant [Term] id: WBPhenotype:0001597 name: muscle missing def: "Any variation that results in a fewer than control number of muscle cells." [WB:WBPaper00001423, WB:WBPaper00002946, WB:WBPerson2021] is_a: WBPhenotype:0000622 ! muscle system development variant [Term] id: WBPhenotype:0001598 name: inhibitor of serotonin uptake variant def: "Treatment with inhibitors of serotonin reuptake does not elicit the same response as observed for control animals." [WB:WBPerson712] synonym: "inhibitor of serotonin uptake abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001599 name: ouabain resistant def: "Animals fail to respond to the concentration of ouabain that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, resistance to ouabain is often assayed via body contraction response." [WB:WBPaper00000484, WB:WBPerson2021] is_a: WBPhenotype:0000331 ! inhibitors of na k atpase resistant [Term] id: WBPhenotype:0001600 name: contraction response to ouabain resistant def: "Animals require increased concentration or longer exposure to ouabain to elicit the rapid muscular contractions seen in control animals." [WB:WBPaper00000484] is_a: WBPhenotype:0001599 ! ouabain resistant [Term] id: WBPhenotype:0001601 name: biogenic amine receptor antagonist resistant def: "Animals fail to respond to the concentration of biogenic amine receptor antagonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson712] synonym: "serotonin receptor antagonist" NARROW [] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0001602 name: methiothepin resistant def: "Animals fail to respond to the concentration of methiothepin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00031241, WB:WBPerson721] is_a: WBPhenotype:0001601 ! biogenic amine receptor antagonist resistant [Term] id: WBPhenotype:0001603 name: cyproheptadine resistant def: "Animals fail to respond to the concentration of cyproheptadine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00031241, WB:WBPerson721] is_a: WBPhenotype:0001601 ! biogenic amine receptor antagonist resistant [Term] id: WBPhenotype:0001604 name: mianserin resistant def: "Animals fail to respond to the concentration of mianserin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00031241, WB:WBPerson721] synonym: "dibenzazepine resistant" RELATED [] is_a: WBPhenotype:0001601 ! biogenic amine receptor antagonist resistant [Term] id: WBPhenotype:0001605 name: extended life span response to mianserin resistant def: "Animals do not live longer in response to mianserin compared to control." [WB:WBPaper00031241, WB:WBPerson721] is_a: WBPhenotype:0001604 ! mianserin resistant [Term] id: WBPhenotype:0001606 name: ethanol hypersensitive def: "Animals respond to ethanol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00002358, WB:WBPerson712] synonym: "alcohol sensistive" BROAD [] is_a: WBPhenotype:0000008 ! anesthetic hypersensitive [Term] id: WBPhenotype:0001607 name: paralysis response to ethanol hypersensitive def: "Animals become paralyzed in response to ethanol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00002358, WB:WBPerson712] is_a: WBPhenotype:0001606 ! ethanol hypersensitive [Term] id: WBPhenotype:0001608 name: enflurane hypersensitive def: "Animals respond to the anesthetic enflurane at lower concentrations or shorter exposure times than control animals." [WB:WBPaper00002037, WB:WBPerson721] synonym: "ether hypersensitive" RELATED [] is_a: WBPhenotype:0000008 ! anesthetic hypersensitive [Term] id: WBPhenotype:0001609 name: isoflurane hypersensitive def: "Animals respond to the anesthetic isoflurane at lower concentrations or shorter response times than control animals." [WB:WBPaper00002037, WB:WBPerson721] synonym: "ether hypersensitive" RELATED [] is_a: WBPhenotype:0000008 ! anesthetic hypersensitive [Term] id: WBPhenotype:0001610 name: diethyl ether hypersensitive def: "Animals respond to the anesthetic ether at lower concentrations or shorter response times than control animals." [WB:WBPaper00001063, WB:WBPaper00002037, WB:WBPerson721] synonym: "ether hypersensitive" RELATED [] is_a: WBPhenotype:0000008 ! anesthetic hypersensitive [Term] id: WBPhenotype:0001611 name: halothane hypersensitive def: "Animals respond to the lipid-soluble anesthetic halothane at lower concentrations or shorter response times compared to control animals." [WB:WBPaper00000958, WB:WBPaper00031286, WB:WBPerson721] is_a: WBPhenotype:0000008 ! anesthetic hypersensitive [Term] id: WBPhenotype:0001612 name: ethanol resistant def: "Animals fail to respond to the concentration of ethanol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to ethanol to elicit the response compared to control animals." [WB:WBPaper00002358, WB:WBPaper00031371, WB:WBPerson557, WB:WBPerson712] synonym: "alcohol resistant" BROAD [] synonym: "Jud" BROAD [] is_a: WBPhenotype:0000009 ! anesthetic resistant [Term] id: WBPhenotype:0001613 name: paralysis response to ethanol resistant def: "Animals in the presence of ethanol continue to respond to touch under conditions when control worms have stopped responding to stimuli." [WB:WBPaper00031371, WB:WBPerson712] is_a: WBPhenotype:0001612 ! ethanol resistant [Term] id: WBPhenotype:0001614 name: anticonvulsant response variant def: "Animals exhibit variations in their response to a specific anticonvulsant compared to that observed in control animals." [WB:WBPerson557] synonym: "anticonvulsant response abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001615 name: anticonvulsant resistant def: "Animals fail to respond to the concentration of compounds that act as anticonvulsants that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00024698, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000011 ! drug resistant is_a: WBPhenotype:0001614 ! anticonvulsant response variant [Term] id: WBPhenotype:0001616 name: trimethadione resistant def: "Animals fail to respond to the concentration of trimethadione, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00024698, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0001615 ! anticonvulsant resistant [Term] id: WBPhenotype:0001617 name: ethosuximide resistant def: "Animals fail to respond to the concentration of ethosuximide, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson712] is_a: WBPhenotype:0001615 ! anticonvulsant resistant [Term] id: WBPhenotype:0001618 name: halothane resistant def: "Animals fail to respond to the concentration of the anesthetic halothane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00004721, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000009 ! anesthetic resistant [Term] id: WBPhenotype:0001619 name: isoflurane resistant def: "Animals fail to respond to the concentration of the volatile anesthetic isoflurane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00004721, WB:WBPerson712] is_a: WBPhenotype:0000009 ! anesthetic resistant [Term] id: WBPhenotype:0001620 name: organism oxidative stress response variant def: "Animals exhibit variations in their response to oxidative stress compared to that observed in control animals." [WB:WBPerson557] synonym: "organism oxidative stress response abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0001621 name: organism oxidative stress response hypersensitive def: "Animals respond to a lower concentration of reactive oxygen species or a shorter exposure compared to control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001620 ! organism oxidative stress response variant [Term] id: WBPhenotype:0001622 name: egg laying serotonin hypersensitive def: "Animals lay eggs at a greater rate in response to exogenous serotonin compared to control animals." [WB:WBPaper00002487, WB:WBPerson712] is_a: WBPhenotype:0000023 ! serotonin hypersensitive is_a: WBPhenotype:0001629 ! egg laying serotonin variant [Term] id: WBPhenotype:0001623 name: male tail curling serotonin variant def: "Any variation in the posture of the male tail after application of exogenous serotonin compared to control. In C. elegans, males respond with a tight ventral curling of the male tail in response to serotonin." [WB:WBPaper00001861, WB:WBPerson557] synonym: "male tail curling serotonin abnormal" NARROW [] is_a: WBPhenotype:0001232 ! serotonin response variant [Term] id: WBPhenotype:0001624 name: male tail curling serotonin resistant def: "Animals fail to respond to the concentration of serotonin that elicits a male tail curling response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body." [WB:WBPaper00001861, WB:WBPerson557] is_a: WBPhenotype:0000024 ! serotonin resistant is_a: WBPhenotype:0001623 ! male tail curling serotonin variant [Term] id: WBPhenotype:0001625 name: male tail curling serotonin hypersensitive def: "Males respond to serotonin by curling their tails at a lower concentration or a shorter exposure compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body." [WB:WBPaper00001861, WB:WBPaper00028762, WB:WBPerson557] is_a: WBPhenotype:0000023 ! serotonin hypersensitive is_a: WBPhenotype:0001623 ! male tail curling serotonin variant [Term] id: WBPhenotype:0001626 name: locomotion rate serotonin variant def: "Any variation in the locomotion rate after application of exogenous serotonin compared to control." [WB:WBPaper00002141] synonym: "locomotion rate serotonin abnormal" NARROW [] is_a: WBPhenotype:0001232 ! serotonin response variant [Term] id: WBPhenotype:0001627 name: locomotion rate serotonin hypersensitive def: "The decrease in locomotion rate in the presence of serotonin is greater than control animals." [WB:WBPaper00002141] synonym: "locomotion rate serotonin reduced" RELATED [] is_a: WBPhenotype:0000023 ! serotonin hypersensitive is_a: WBPhenotype:0001626 ! locomotion rate serotonin variant [Term] id: WBPhenotype:0001628 name: locomotion rate serotonin resistant def: "Animals fail to decrease their locomotion rate in response the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00002141] synonym: "locomotion rate serotonin increased" RELATED [] is_a: WBPhenotype:0000024 ! serotonin resistant is_a: WBPhenotype:0001626 ! locomotion rate serotonin variant [Term] id: WBPhenotype:0001629 name: egg laying serotonin variant def: "Any variation in egg laying behavior after application of exogenous serotonin compared to control. In C. elegans, serotonin induces egg laying." [WB:WBPaper00000635, WB:WBPerson712] synonym: "egg laying serotonin abnormal" NARROW [] is_a: WBPhenotype:0001101 ! egg laying response to drug variant is_a: WBPhenotype:0001232 ! serotonin response variant [Term] id: WBPhenotype:0001630 name: gut obstructed def: "Any variation in the developmental progression of the intestine that leads to a blockage in the alimentary canal." [WB:WBPerson2021, WB:WBPerson557] synonym: "Gob" BROAD [] is_a: WBPhenotype:0000708 ! intestinal development variant [Term] id: WBPhenotype:0001631 name: nullo X gamete def: "Animals produce ova/sperm that contain no X chromosome in a nonmendelian segregation pattern." [WB:WBPaper00000179, WB:WBPerson712] synonym: "nullo X gamete abnormal" NARROW [] is_a: WBPhenotype:0001664 ! X chromosome nondisjunction [Term] id: WBPhenotype:0001632 name: diplo X gamete def: "Animals produce ova/sperm that contain 2 X chromosomes." [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X chromosome nondisjunction [Term] id: WBPhenotype:0001633 name: lethal gamete def: "Animals produce ova/sperm that contain lethal factors as a result of chromosomal disjunction defects." [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001174 ! chromosome disjunction defective [Term] id: WBPhenotype:0001634 name: organism electrophilic stress hypersensitive def: "Animals respond to compounds that elicit electrophilic stress at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0001635 name: excess pharyngeal cells def: "Animals contain an excess number of pharyngeal cells compared to control. In C. elegans, pharyngeal cells are derived from MS-blastomere. The overproduction of pharyngeal tissues is a result of other blastomeres adopting an MS-like fate." [WB:WBPaper00001584, WB:WBPaper00002922, WB:WBperson2021] is_a: WBPhenotype:0000707 ! pharyngeal development variant [Term] id: WBPhenotype:0001636 name: excess intestinal cells def: "Animals contain an excess number of intestinal cells compared to control. In C. elegans, intestinal cells are derived from E-blastomere. The overproduction of intestinal tissues is a result of other blastomeres adopting an E-like fate or excess cell proliferation in the E lineage." [WB:WBPaper00001584, WB:WBPaper00002330, WB:WBperson2021] is_a: WBPhenotype:0000708 ! intestinal development variant [Term] id: WBPhenotype:0001637 name: no Intestine def: "Embryos fail to generate cells that exhibit intestinal specification. In C. elegans, the E blastomere is the precursor of all the intestinal cells." [WB:WBPaper00002946, WB:WBperson2021] is_a: WBPhenotype:0000708 ! intestinal development variant [Term] id: WBPhenotype:0001638 name: endosome fusion defective def: "Animals are deficient in the formation or disassembly of lysosomes." [GO:0034058, WB:WBPaper00029049, WB:WBPerson712] is_a: WBPhenotype:0001422 ! endocytic transport defect [Term] id: WBPhenotype:0001639 name: roaming reduced def: "Animals do not move more than a few body lengths from their starting position, searches occur locally with pivoting behavior." [WB:WBPaper00003743, WB:WBPaper00031455, WB:WBPerson712] synonym: "lurcher" RELATED [] is_a: WBPhenotype:0000238 ! foraging reduced [Term] id: WBPhenotype:0001640 name: acidification level defective def: "Animals are unable to acidify compartments to the same level as that observed in control animals given the same stimulus." [WB:WBPaper00031246, WB:WBPerson712] synonym: "acidification level abnormal" NARROW [] is_a: WBPhenotype:0000607 ! coelomic system physiology variant [Term] id: WBPhenotype:0001641 name: posterior body wall contraction defective def: "Animals lack or exhibit defects in the posterior body muscle contractions during the defecation cycle." [WB:WBPaper00031426, WB:WBPerson712] synonym: "pBoc" RELATED [] is_a: WBPhenotype:0000157 ! posterior body wall contraction defecation cycle variant [Term] id: WBPhenotype:0001642 name: cell cleavage variant emb def: "Variations that disrupt stereotypical embryonic cleavage patterns (such as cleavage rate, division axes or asymmetric division)." [GO:0040016, WB:WBPaper00001032, WB:WBPerson2021] synonym: "cell cleavage abnormal" NARROW [] is_a: WBPhenotype:0001018 ! cytokinesis variant emb [Term] id: WBPhenotype:0001643 name: excess hypodermal cells def: "Embryos generate an excess number of hypodermal cells compared to control." [WB:WBPerson2021] synonym: "Skn" BROAD [] is_a: WBPhenotype:0000701 ! epithelial development variant [Term] id: WBPhenotype:0001644 name: protein metabolism variant def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of proteins in the organism compared to control." [WB:WBPerson557] synonym: "protein metabolism abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0001645 name: protein degradation variant def: "Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control." [GO:0030163, WB:WBPerson2021] synonym: "protein degradation abnormal" NARROW [] is_a: WBPhenotype:0001644 ! protein metabolism variant [Term] id: WBPhenotype:0001646 name: no pharynx def: "Embryos fail to generate cells that exhibit pharyngeal specification." [WB:WBPaper00001521, WB:WBPerson2021] synonym: "Pha" BROAD [] is_a: WBPhenotype:0000707 ! pharyngeal development variant [Term] id: WBPhenotype:0001647 name: posterior pharynx variant def: "Any variation in the progression of the posterior portion of the pharynx over time compared to control. In C. elegans the posterior region includes the isthmus and terminal bulb (second bulb)." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior pharynx abnormal" NARROW [] is_a: WBPhenotype:0000707 ! pharyngeal development variant [Term] id: WBPhenotype:0001648 name: no posterior pharynx def: "Embryos fail to generate cells that give rise to the posterior portion of the pharynx. In C. elegans, the MS blastomere- derived pharyngeal cells constitute the posterior portion of the pharynx." [WB:WBPaper00002330, WB:WBPerson2021] is_a: WBPhenotype:0001646 ! no pharynx is_a: WBPhenotype:0001647 ! posterior pharynx variant [Term] id: WBPhenotype:0001649 name: Fluorouracil resistant def: "Animals fail to respond to the concentration of Fluorouracil (5-FU) that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. Elegans Fluorouracil induces germ cell death, inhibits embryogenesis and inhibits larval growth (depending on dose) in control animals." [WB:WBPaper00031571, WB:WBPerson721] synonym: "5 FU resistant" EXACT [] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0001650 name: germ cell death response to 5 FU resistant def: "Germ cell death fails in response to the concentration of 5-FU that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, in addition to cell death, 5-FU exposed animals exhibit condensed germ cell nuclei or unhealthy nuclei." [WB:WBPaper00031571, WB:WBPerson721] is_a: WBPhenotype:0001649 ! Fluorouracil resistant [Term] id: WBPhenotype:0001651 name: growth arrest response to 5 FU resistant def: "Animals grow well during or after exposure to 5-FU under conditions where control animals are growth inhibited." [WB:WBPaper00031571, WB:WBPerson721] is_a: WBPhenotype:0001649 ! Fluorouracil resistant [Term] id: WBPhenotype:0001652 name: anchor cell invasion variant def: "Any variation in the process by which the gonad anchor cell makes contact with vulval cells in order to create a uterine-vulval connection. In C. elegans, this includes the loss of the basement membranes between these cells and the crossing of the basolateral portion of the anchor cell through this gap." [WB:WBPaper00005989] synonym: "anchor cell invasion abnormal" NARROW [] is_a: WBPhenotype:0000283 ! vulva uterus connection defective [Term] id: WBPhenotype:0001653 name: cadmium response variant def: "Animals exhibit variations in their response to cadmium compared to that observed in control animals." [WB:WBPerson557] synonym: "cadmium response abnormal" NARROW [] is_a: WBPhenotype:0000591 ! metal response variant [Term] id: WBPhenotype:0001654 name: cadmium resistant def: "Animals fail to respond to the concentration of cadmium that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to cadmium to elicit the response compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001653 ! cadmium response variant [Term] id: WBPhenotype:0001655 name: cadmium hypersensitive def: "Animals respond to cadmium at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001653 ! cadmium response variant [Term] id: WBPhenotype:0001656 name: distal tip cell development variant def: "Any variation in the progression of the leader cell that guides and shapes the outgrowth of the gonad while crawling along the bodywall to force the germline to extend into a long tubular shape over time from its formation to its mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "distal tip cell development abnormal" NARROW [] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0001657 name: cell junction variant def: "Animals exhibit variations in the specialized region of connection between two cells or between a cell and the extracellular matrix compared to control." [GO:0030054, WB:WBPaper00031590, WB:WBPerson712] synonym: "cell junction abnormal" NARROW [] is_a: WBPhenotype:0001399 ! cell membrane morphology variant [Term] id: WBPhenotype:0001658 name: intercellular junction variant def: "Animals exhibit variations in the specialized region of connection between two cells compared to control." [GO:0005911, WB:WBPaper00031590, WB:WBPerson712] synonym: "cell cell junction abnormal" RELATED [] synonym: "intercellular junction abnormal" NARROW [] is_a: WBPhenotype:0001657 ! cell junction variant [Term] id: WBPhenotype:0001659 name: spermatheca morphology variant def: "Any variation in the form, structure or composition of the somatic gonad structure that connects the distal gonad arm to the uterus compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "spermatheca morphology abnormal" NARROW [] is_a: WBPhenotype:0000977 ! somatic gonad morphology variant [Term] id: WBPhenotype:0001660 name: loss of asymmetry ASE def: "The two morphologically bilaterally symmetric gustatory neurons ASE left (ASEL) and ASE right (ASER) fail to undergo a left/right asymmetric diversification in cell fate." [WB:WBPaper00030973, WB:WBPerson2021] synonym: "" RELATED [] synonym: "2ASEL" NARROW [] synonym: "2ASER" NARROW [] is_a: WBPhenotype:0001510 ! neuronal cell fate specification variant is_a: WBPhenotype:0001512 ! loss of left right asymmetry [Term] id: WBPhenotype:0001661 name: loss of asymmetry AWC def: "The two morphologically bilaterally symmetric olfactory neurons AWC left (AWCL) and AWC right (AWCR) fail to undergo a left/right asymmetric diversification in cell fate." [WB:WBPaper00003760, WB:WBPerson2021] synonym: "" RELATED [] synonym: "2 AWC off" NARROW [] synonym: "2 AWC on" NARROW [] is_a: WBPhenotype:0001510 ! neuronal cell fate specification variant is_a: WBPhenotype:0001512 ! loss of left right asymmetry [Term] id: WBPhenotype:0001662 name: spermatheca development variant def: "Any variation in the progression of the somatic gonad structure that connects the distal gonad arm to the uterus over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "spermatheca development abnormal" NARROW [] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0001663 name: organism oxidative stress resistant def: "Animals fail to respond to the levels of reactive oxygen species that elicit a response in control animals." [WB:WBPerson2021] synonym: "Oxr" BROAD [] is_a: WBPhenotype:0001620 ! organism oxidative stress response variant [Term] id: WBPhenotype:0001664 name: X chromosome nondisjunction def: "The frequency of sex chromosome segregation is perturbed, resulting in the production of exceptional gametes (e.g. ova or sperm) and populations with a sex ratio altered from the rate of 1:500 as observed for control populations." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0001174 ! chromosome disjunction defective [Term] id: WBPhenotype:0001665 name: low incidence male progeny def: "Lower numbers of male progeny occur in the population as a result of a decrease in the rate of X chromosome nondisjunction compared to control." [WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X chromosome nondisjunction [Term] id: WBPhenotype:0001666 name: organism hypersensitive X ray irradiation def: "Animals respond to iononizing radiation at a lower dose or a shorter exposure compared to control animals. Iononizing radiation has a wavelength in the 10 to 0.01 nanometer range. In C. elegans, increased sensitivity to X-ray irradiation is often observed as a decrease in survival upon exposure compared to control animals given the same treatment." [WB:WBPaper00000565, WB:WBPaper00003886, WB:WBPerson712] is_a: WBPhenotype:0000276 ! organism X ray response variant is_a: WBPhenotype:0000711 ! organism hypersensitive ionizing radiation [Term] id: WBPhenotype:0001667 name: methyl methanesulfonate hypersensitive def: "Animals respond to the chemical mutagen methyl methanesulfonate (MMS) a methanesulfonate ester and alkylating agent at a lower concentration or a shorter exposure compared to control animals. In C. elegans, increased sensitivity to MMS can be observed as a decrease in egg hatch upon acute exposure or inhibition of growth after chronic exposure compared to control animals given the same treatment." [WB:WBPaper00000565, WB:WBPerson712] synonym: "MMS hypersensitive" EXACT [] is_a: WBPhenotype:0000498 ! methyl methanesulfonate response variant [Term] id: WBPhenotype:0001668 name: oocyte accumulation def: "An increased number of oocytes are retained in the gonad without becoming endomitotic, compared to control. " [WB:WBPaper00006281, WB:WBPaper00030855] synonym: "oocyte number increased" RELATED [] is_a: WBPhenotype:0001260 ! oocyte morphology variant [Term] id: WBPhenotype:0001669 name: presynaptic vesicle number variant def: "Animals exhibit a variation in the ratio of synaptic vesicles per synapse of a neuron, compared to control animals." [WB:WBPaper00027305, WB:WBPerson712] synonym: "presynaptic vesicle number abnormal" NARROW [] synonym: "synaptic vesicle number abnormal" RELATED [] is_a: WBPhenotype:0001321 ! presynaptic region morphology variant [Term] id: WBPhenotype:0001670 name: presynaptic vesicle number reduced def: "Animals exhibit an overall decrease in the quantity of synaptic vesicles at the synapse compared to control animals." [WB:WBPaper00027305, WB:WBPerson712] synonym: "synaptic vesicle number reduced" RELATED [] is_a: WBPhenotype:0001669 ! presynaptic vesicle number variant [Term] id: WBPhenotype:0001671 name: vesicle organization variant def: "Animals display variations in the distribution of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "vesicle organization abnormal" NARROW [] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0001672 name: commisure growth variant def: "Animals exhibit variations in the extension of the part of the axon that forms a bridge between body regions, compared to control animals." [WB:WBPerson2021, WB:WBPerson712] synonym: "commisure growth abnormal" NARROW [] is_a: WBPhenotype:0001224 ! axon outgrowth variant [Term] id: WBPhenotype:0001673 name: telomere homeostasis variant def: "Animals exhibit variations in the processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA, which allow the chromosome to persist from generation to generation, compared to control." [GO:0032204, WB:WBPaper00031585, WB:WBPerson712] synonym: "telomere homeostasis abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0001674 name: telomere morphology variant def: "Animals exhibit variations in the sequence or organization of the components of the terminal region of its chromosome, (i.e. telomere, which serves to stabilize the chromosome) compared to control." [GO:0000781, WB:WBPaper00003886, WB:WBPerson712] synonym: "telomere morphology abnormal" NARROW [] is_a: WBPhenotype:0001348 ! chromosome morphology variant [Term] id: WBPhenotype:0001675 name: male gonad development variant def: "Males exhibit variations in the reproductive system, from its formation to the mature structure compared to control." [WB:WBPerson712] synonym: "male gonad development abnormal" NARROW [] is_a: WBPhenotype:0000691 ! gonad development variant [Term] id: WBPhenotype:0001676 name: touch receptor cell morphology variant def: "Animals exhibit variations in the structure or composition of any neuron within the class of sensory neurons responsible for relaying mechanical stimuli to the animal compared to control." [WB:WBPaper00000550, WB:WBPerson712] synonym: "mechanosensory neuron abnormal" RELATED [] synonym: "microtubule cell morphology abnormal" RELATED [] synonym: "touch receptor cell morphology abnormal" NARROW [] is_a: WBPhenotype:0000905 ! neuron morphology variant [Term] id: WBPhenotype:0001677 name: stage specific cuticle antigenicity variant def: "Animals display cuticle components displayed by animals of a different developmental stage, compared to control." [WB:WBPaper00002589, WB:WBPerson712] synonym: "Srf" NARROW [] synonym: "stage specific cuticle antigenicity abnormal" NARROW [] is_a: WBPhenotype:0001687 ! surface antigenicity variant [Term] id: WBPhenotype:0001678 name: cuticle physiology variant def: "Animals produce cuticles that vary in components such as proteins or carbohydrates, observed in control animals of the same developmental stage and raised under the same conditions." [WB:WBPaper00001576, WB:WBPerson712] synonym: "cuticle physiology abnormal" NARROW [] is_a: WBPhenotype:0001210 ! pericellular component physiology variant [Term] id: WBPhenotype:0001679 name: multipolar neuron def: "Neurons have more than one process extending from the cell body." [WB:WBPaper00031901, WB:WBPerson712] is_a: WBPhenotype:0000905 ! neuron morphology variant [Term] id: WBPhenotype:0001680 name: adoption of fused vulval cell fate def: "Vulval precursor cells forgo further cell division and fuse to the hypodermis instead of adopting their intended fate (becoming primary, secondary or tertiary vulval cells)." [WB:WBPerson2021, WB:WBPerson712] synonym: "F fate abnormal " RELATED [] synonym: "VPC fused fate abnormal" RELATED [] is_a: WBPhenotype:0001272 ! vulval cell induction variant [Term] id: WBPhenotype:0001681 name: spindle orientation variant def: "The alignment of the spindle relative to other cellular structures varies from that observed in control animals." [GO:0051294, WB:WBPaper00031898, WB:WBPerson712] synonym: "spindle orientation abnormal" NARROW [] is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant [Term] id: WBPhenotype:0001682 name: organism UV resistant def: "Organisms respond to UV at a higer dose or a longer exposure compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000143 ! organism UV response variant [Term] id: WBPhenotype:0001683 name: spermatogenesis defective hermaphrodite def: "Variations that specifically disrupt sperm production in XX hermaphrodites. By contrast, spermatogenesis in XO males remains unaffected." [WB:WBPaper00002113, WB:WBPaper00002631] is_a: WBPhenotype:0000670 ! spermatogenesis variant [Term] id: WBPhenotype:0001684 name: synaptic vesicle homeostasis variant def: "The rates of synaptic vesicle exocytosis and endocytosis vary from that observed in control animals." [WB:WBPaper00031872, WB:WBPerson712] synonym: "synaptic vesicle homeostasis abnormal" NARROW [] is_a: WBPhenotype:0000846 ! presynaptic region physiology variant [Term] id: WBPhenotype:0001685 name: postsynaptic region morphology variant def: "The region opposite to the presynaptic region deviates in the structure, configuration or ratio of its components specific for receiving signals from the other side of the synapse compared to control." [WB:WBPaper00031872, WB:WBPerson712] synonym: "postsynaptic region morphology abnormal" NARROW [] is_a: WBPhenotype:0000616 ! synapse morphology variant [Term] id: WBPhenotype:0001686 name: postsynaptic region physiology variant def: "Animals exhibit variations in any physical or chemical process in the region, opposite to the presynaptic region, which is required for receiving signals from the other side of the synapse compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "postsynaptic region physiology abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic transmission variant [Term] id: WBPhenotype:0001687 name: surface antigenicity variant def: "Cuticles of animals or cuticular extracts exhibit an altered pattern of antibody binding compared to Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712] synonym: "Srf" BROAD [] synonym: "surface antigenicity abnormal" NARROW [] is_a: WBPhenotype:0001688 ! surface coat variant [Term] id: WBPhenotype:0001688 name: surface coat variant def: "The electron dense, amorphous envelope that comprises the outermost layer of the cuticle varies in composition from that observed in control animals of the same developmental stage. The integrity of the surface coat is often revealed by an altered antigenicity or biochemical make up." [GO:0060104] synonym: "Srf" BROAD [] synonym: "surface coat abnormal" NARROW [] is_a: WBPhenotype:0000201 ! cuticle development variant is_a: WBPhenotype:0001678 ! cuticle physiology variant [Term] id: WBPhenotype:0001689 name: surface antigen negative def: "Cuticles or cuticular extracts do not bind antibodies that are observed to bind the surfaces or cuticular extracts of Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712] synonym: "Srf" NARROW [] is_a: WBPhenotype:0001687 ! surface antigenicity variant [Term] id: WBPhenotype:0001690 name: constitutive larval display def: "Animals display surface antigens throughout all larval stages, unlike Bristol N2 worms, which display the antigens only during one larval stage." [WB:WBPaper00002589, WB:WBPerson712] synonym: "Cld" BROAD [] is_a: WBPhenotype:0001677 ! stage specific cuticle antigenicity variant [Term] id: WBPhenotype:0001691 name: germ nuclei rachis def: "Germ nuclei are misplaced in the gonad and are observed in the rachis. Sheath cells are observed protruding between these nuclei. Meiotic or mitotic specification of germ nuclei is not affected." [WB:WBPaper00031889, WB:WBPerson712] synonym: "germ line morphogenesis(Glm)" NARROW [] is_a: WBPhenotype:0001940 ! rachis morphology variant [Term] id: WBPhenotype:0001692 name: pheromone induced larval display defective def: "Animals are not induced to display surface antigens by exposure to pheromone as observed for Bristol N2 animals." [WB:WBPaper00002589, WB:WBPerson712] synonym: "ILD abnormal" EXACT [] synonym: "induced larval display abnormal" RELATED [] synonym: "pheromone induced larval display abnormal" NARROW [] is_a: WBPhenotype:0001687 ! surface antigenicity variant [Term] id: WBPhenotype:0001693 name: male posterior alae def: "Males have alae that extend into the tail region. Alae are small linear ridges running along the lateral lines of the cuticle. In C. elegans alae do not extend into the tail region (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Pal" BROAD [] is_a: WBPhenotype:0000202 ! alae variant is_a: WBPhenotype:0001240 ! male tail sensory ray differentiation variant [Term] id: WBPhenotype:0001694 name: spermatogenesis to oogenesis switch defective def: "Hermaphrodites continue to produce sperm past the time at which the transition to oogenesis normally occurs. Thus, germ cells that would normally become oocytes are transformed into sperm instead." [WB:WBPaper00001883, WB:WBPaper00002113, WB:WBPerson2021] synonym: "spermatogenesis to oogenesis switch abnormal" NARROW [] is_a: WBPhenotype:0001572 ! masculinized [Term] id: WBPhenotype:0001695 name: glycosyltransferase activity variant def: "Animals exhibit variations in their catalytic ability the transfer glycolsyl groups from one compound (donor) to another (acceptor) often measured by a reduction in the amount of glycosylated products compared to that observed in control animals of the same developmental stage." [GO:0016757, WB:WBPerson712] synonym: "glycosyltransferase activity abnormal" NARROW [] is_a: WBPhenotype:0000733 ! catalysis variant [Term] id: WBPhenotype:0001696 name: biosynthesis variant def: "Animals exhibit variations in the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones compared to control." [GO:0009058, WB:WBPaper00029024, WB:WBPerson712] synonym: "biosynthesis abnormal" NARROW [] is_a: WBPhenotype:0000463 ! metabolic pathway variant [Term] id: WBPhenotype:0001697 name: chondroitin biosynthesis variant def: "Animals exhibit variations in the chemical reactions and pathways resulting in the formation of chondroitin sulfate compared to control." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712] synonym: "chondroitin biosynthesis abnormal" NARROW [] is_a: WBPhenotype:0001696 ! biosynthesis variant [Term] id: WBPhenotype:0001698 name: heparan sulfate biosynthesis variant def: "Animals exhibit variations in the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan compared to control." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712] synonym: "heparan sulfate biosynthesis abnormal" NARROW [] is_a: WBPhenotype:0001696 ! biosynthesis variant [Term] id: WBPhenotype:0001699 name: localized movement variant def: "Specific body regions of an animal display variations in movement compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "localized movement abnormal" NARROW [] is_a: WBPhenotype:0001206 ! movement variant [Term] id: WBPhenotype:0001700 name: swimming variant def: "Animals exhibit variations in movement in liquid from that observed for control animals." [WB:WBPaper00031835, WB:WBPerson712] synonym: "movement in liquid abnormal" RELATED [] synonym: "swimming abnormal" NARROW [] synonym: "thrashing abnormal" RELATED [] is_a: WBPhenotype:0001206 ! movement variant [Term] id: WBPhenotype:0001701 name: spastic locomotion def: "Animals exhibit uncharacteristic muscle contractions during the process by which they travel from one location to another." [WB:WBPerson2021, WB:WBPerson557] synonym: "convulsive" RELATED [] is_a: WBPhenotype:0004017 ! locomotor coordination variant [Term] id: WBPhenotype:0001702 name: directionality variant def: "Animals exhibit variations in the directional changes that separate consecutive runs, from that observed for control animals. In C. elegans, these aberrations include variations in the form or extent of omega turns or reversals (shifts from forward to backward movements)." [WB:WBPaper00000075, WB:WBPaper00003740, WB:WBPaper00031656, WB:WBPerson712] synonym: "directionality abnormal" NARROW [] synonym: "reversal abnormal" RELATED [] synonym: "turning abnormal" RELATED [] is_a: WBPhenotype:0004017 ! locomotor coordination variant [Term] id: WBPhenotype:0001703 name: body bend variant def: "Any variation in the maximum ventral and dorsal flex of the animal compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body bend abnormal" NARROW [] is_a: WBPhenotype:0004018 ! sinusoidal movement variant [Term] id: WBPhenotype:0001704 name: multiple alae def: "Alae contain more cuticular ridges than control animals. In C. elegans alae are composed of three cuticular ridges." [WB:WBPaper00026841, WB:WBPerson557] is_a: WBPhenotype:0001412 ! alae morphology variant [Term] id: WBPhenotype:0001705 name: nucleocytoplasmic transport defective def: "The directed movement of molecules between the nucleus and the cytoplasm is impaired." [GO:0006913, WB:WBPerson557] synonym: "nucleocytoplasmic transport abnormal" NARROW [] is_a: WBPhenotype:0001283 ! organelle metabolism variant [Term] id: WBPhenotype:0001706 name: nuclear export defective def: "The directed movement of substances out of the nucleus is impaired." [GO:0051168, WB:WBPerson557] synonym: "nuclear export abnormal" NARROW [] is_a: WBPhenotype:0001705 ! nucleocytoplasmic transport defective [Term] id: WBPhenotype:0001707 name: nuclear import defective def: "The directed movement of substances into the nucleus is impaired." [GO:0051170, WB:WBPerson557] synonym: "nuclear import abnormal" NARROW [] is_a: WBPhenotype:0001705 ! nucleocytoplasmic transport defective [Term] id: WBPhenotype:0001708 name: protein export from nucleus defective def: "The directed movement of a protein from the nucleus into the cytoplasm is impaired." [GO:0006611, WB:WBPerson557] synonym: "protein export from nucleus abnormal" NARROW [] is_a: WBPhenotype:0001706 ! nuclear export defective [Term] id: WBPhenotype:0001709 name: rhythmic tolerance to stress variant def: "Animals exhibit variations in light/dark cycle recurrence of reactions to stress conditions compared to that observed for control animals." [WB:WBPaper00032037, WB:WBPerson712] synonym: "circadian variation in stress tolerance abnormal" RELATED [] synonym: "rhythmic tolerance to stress abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant is_a: WBPhenotype:0001711 ! rhythmic behavior variant [Term] id: WBPhenotype:0001710 name: rhythmic tolerance to osmotic stress variant def: "Animals exhibit variations in light/dark cycle recurrence of reactions to osmotic stress compared to that observed for control animals." [WB:WBPaper00032037, WB:WBPerson712] synonym: "rhythmic tolerance to osmotic stress abnormal" NARROW [] is_a: WBPhenotype:0001709 ! rhythmic tolerance to stress variant [Term] id: WBPhenotype:0001711 name: rhythmic behavior variant def: "Animals exhibit variations in actions or responses that occur with measurable periodicity, from that observed for control animals." [GO:0007622, WB:WBPerson712] synonym: "rhythmic behavior abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0001712 name: circadian rhythm behavior variant def: "Animals exhibit variations in the actions or reactions that recur with a periodicity associated with light/dark cycles, compared to control." [GO:0048512, WB:WBPaper00032037, WB:WBPerson712] synonym: "circadian rhythm behavior abnormal" NARROW [] is_a: WBPhenotype:0001711 ! rhythmic behavior variant [Term] id: WBPhenotype:0001713 name: locomotory rhythm variant def: "Animals exhibit variations in locomotor activity during its light/dark cycle from that observed in control animals." [GO:0045475, WB:WBPaper00031656, WB:WBPerson712] synonym: "locomotory rhythm abnormal" NARROW [] is_a: WBPhenotype:0001711 ! rhythmic behavior variant [Term] id: WBPhenotype:0001714 name: pirouette variant def: "Animals exhibit variations in turning bouts, consisting of one or more sharp turning events separating consecutive runs, which serve to orient the animal within a gradient, compared to control." [WB:WBPaper00003740, WB:WBPaper00026967, WB:WBPerson712] synonym: "pirouette abnormal" NARROW [] is_a: WBPhenotype:0001702 ! directionality variant [Term] id: WBPhenotype:0001715 name: pirouette frequency variant def: "Animals exhibit variations in the number of directional changes over time from that observed for control animals." [WB:WBPaper00031656, WB:WBPerson712] synonym: "frequency of directionality abnormal" NARROW [] synonym: "pirouette frequency abnormal" NARROW [] is_a: WBPhenotype:0001714 ! pirouette variant [Term] id: WBPhenotype:0001716 name: forward point velocity variant def: "Animals exhibit variations in the translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson712] synonym: "forward point velocity abnormal" NARROW [] is_a: WBPhenotype:0004025 ! velocity of movement variant [Term] id: WBPhenotype:0001717 name: centroid velocity variant def: "Animals exhibit variations in the translocation of the mean position of the rear two-thirds (centroid position) of the animal over time, from that observed for control animals." [WB:WBPaper00024949, WB:WBPaper00031656, WB:WBPerson712] synonym: "centroid velocity abnormal" NARROW [] is_a: WBPhenotype:0004025 ! velocity of movement variant [Term] id: WBPhenotype:0001718 name: instantaneous velocity variant def: "Animals exhibit variations in the mean translocation of the points along the animal's track compared to control." [WB:WBPaper00024949, WB:WBPerson712] synonym: "instantaneous velocity abnormal" NARROW [] is_a: WBPhenotype:0004025 ! velocity of movement variant [Term] id: WBPhenotype:0001719 name: unfolded protein response variant def: "Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones." [GO:0030968, WB:WBPaper00030877, WB:WBPaper00032003, WB:WBPerson557, WB:WBPerson712] synonym: "ER unfolded protein response abnormal " RELATED [] synonym: "unfolded protein response" RELATED [] synonym: "unfolded protein response abnormal" NARROW [] synonym: "UPR" RELATED [] is_a: WBPhenotype:0000142 ! cell stress response variant is_a: WBPhenotype:0001644 ! protein metabolism variant [Term] id: WBPhenotype:0001720 name: spermatozoa retro location defective def: "Spermatozoa do not crawl back into the spermatheca after being swept into the uterus by passing oocytes." [WB:WBPaper00032030, WB:WBPerson712] synonym: "spermatheca homing abnormal" RELATED [] synonym: "spermatozoa retro location abnormal" NARROW [] is_a: WBPhenotype:0000389 ! hermaphrodite sperm fertilization defective is_a: WBPhenotype:0001386 ! fertilization defective hermaphrodite [Term] id: WBPhenotype:0001721 name: pathogen infected pharynx variant def: "Animals exhibit variations in the extent of pathogen invasion into the pharynx compared to control. This is often measured as the percentage of animals exhibiting a pathogen-invaded pharynx within a given population." [WB:WBPaper00032003, WB:WBPerson712] synonym: "pathogen infected pharynx abnormal" NARROW [] is_a: WBPhenotype:0001012 ! organism pathogen response variant [Term] id: WBPhenotype:0001722 name: pathogen infected pharynx increase def: "Animals exhibit a greater extent of pathogen invasion into the pharynx compared to control." [WB:WBPaper00032003, WB:WBPerson712] is_a: WBPhenotype:0001721 ! pathogen infected pharynx variant [Term] id: WBPhenotype:0001723 name: pathogen infected pharynx decrease def: "Animals exhibit a lesser extent of pathogen invasion into the pharynx compared to control." [WB:WBPaper00032003, WB:WBPerson712] is_a: WBPhenotype:0001721 ! pathogen infected pharynx variant [Term] id: WBPhenotype:0001724 name: tunicamycin hypersensitive def: "Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00030877, WB:WBPerson557] is_a: WBPhenotype:0000359 ! tunicamycin response variant [Term] id: WBPhenotype:0001725 name: osmotic stress response variant def: "Animals exhibit variations in the response to osmotic stress compared to control. In C. elegans, exposure to stress-inducing osmotic conditions invokes cellular changes, including transcriptional up or down-regulation of genes." [WB:WBPaper00032031, WB:WBPerson712] synonym: "osmotic stress response abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell stress response variant [Term] id: WBPhenotype:0001726 name: body length variant def: "Animals vary in the distance between anterior and posterior ends of the animal from that observed in control animals." [WB:WBPerson712] synonym: "body length abnormal" NARROW [] is_a: WBPhenotype:0000231 ! body size variant [Term] id: WBPhenotype:0001727 name: body width variant def: "Animals vary in the distance between dorsal and ventral sides when measured across the body at right angles to the length, from that observed in control animals." [WB:WBPerson712] synonym: "body width abnormal" NARROW [] is_a: WBPhenotype:0000231 ! body size variant [Term] id: WBPhenotype:0001728 name: mating plug production variant def: "Males differ from control animals in their ability to form copulatory plugs. In C. elegans, males of the Hawaiian strain (CB4856) typically form mating plugs." [WB:WBPaper00032027, WB:WBPerson712] synonym: "mating plug production abnormal" NARROW [] is_a: WBPhenotype:0000928 ! male physiology variant [Term] id: WBPhenotype:0001729 name: mating plug produced def: "Males form copulatory mating plugs." [WB:WBPaper00002770, WB:WBPerson712] synonym: "mating plug plus" RELATED [] synonym: "plug plus" RELATED [] is_a: WBPhenotype:0001728 ! mating plug production variant [Term] id: WBPhenotype:0001730 name: mating plug deficient def: "Males do not form copulatory mating plug." [WB:WBPaper00002770, WB:WBPerson712] synonym: "mating plug minus" RELATED [] synonym: "plug minus" RELATED [] is_a: WBPhenotype:0001728 ! mating plug production variant [Term] id: WBPhenotype:0001731 name: thermal bias in tracking variant def: "Animals exhibit variations in the duration of the trajectory of the forward track in a thermal gradient compared to control." [WB:WBPaper00032070, WB:WBPerson712] synonym: "cryophilic bias" RELATED [] synonym: "thermal bias in tracking abnormal" NARROW [] is_a: WBPhenotype:0000478 ! isothermal tracking behavior variant [Term] id: WBPhenotype:0001732 name: organism response to pH variant def: "Animals exhibit variations in their response and ability to survive over a range of pH conditions compared to control." [WB:WBPaper00032033, WB:WBPerson712] synonym: "organism response to pH abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0001733 name: pheromone suppressed pumping defective def: "Animals treated with pheromone do not exhibit a decrease in pumping rate similar to that observed for control animals." [WB:WBPaper00032082, WB:WBPerson712] synonym: "pheromone suppressed pumping abnormal" NARROW [] is_a: WBPhenotype:0001287 ! suppressed pharyngeal pumping defective [Term] id: WBPhenotype:0001734 name: starvation suppressed pumping defective def: "Animals deprived of food do not exhibit a decrease in pumping rate similar to that observed for control animals." [WB:WBPaper00032082, WB:WBPerson712] synonym: "food deprived suppression of pumping abnormal" RELATED [] synonym: "starvation suppressed pumping abnormal" NARROW [] is_a: WBPhenotype:0001287 ! suppressed pharyngeal pumping defective [Term] id: WBPhenotype:0001735 name: muscle cell activity variant def: "Animals exhibit variations in the frequency, rate or extent of muscle contraction compared to control animals." [GO:0006937, WB:WBPaper00032000, WB:WBPerson712] synonym: "muscle cell activity abnormal" NARROW [] is_a: WBPhenotype:0000990 ! muscle cell physiology variant [Term] id: WBPhenotype:0001736 name: acetate chemotaxis defective def: "Failure to execute the characteristic response to acetate compared to control animals." [WB:WBPaper00031959, WB:WBPerson712] is_a: WBPhenotype:0000015 ! positive chemotaxis defective [Term] id: WBPhenotype:0001737 name: aqueous compound discrimination defective def: "Animals are unable to locate the gradient peak of a water soluble compound, which was generated on a uniform concentration of another compound." [WB:WBPaper00031959, WB:WBPerson712] synonym: "aqueous compound discrimination abnormal" NARROW [] is_a: WBPhenotype:0001443 ! aqueous chemosensory response variant [Term] id: WBPhenotype:0001738 name: ammonium chemotaxis defective def: "Failure to execute the characteristic response to ammonium compared to control animals." [WB:WBPaper00031959, WB:WBPerson712] is_a: WBPhenotype:0000015 ! positive chemotaxis defective [Term] id: WBPhenotype:0001739 name: aging variant def: "Any variation in an organism's decline over time from its optimal fertility and viability compared to control animals." [WB:WBPaper00032067, WB:WBPerson712] synonym: "aging abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism physiology variant [Term] id: WBPhenotype:0001740 name: organ senescence variant def: "Any variation in the preprogrammed process that occurs in an organism that is associated with the dismantling of an organ and an overall decline in metabolic function compared to control animals. This may include variations in the rate or extent of morphological disarray and of the breakdown or organelles, membranes and other cellular components." [GO:0010260, WB:WBPaper00032067, WB:WBPerson712] synonym: "organ senescence abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ system development variant is_a: WBPhenotype:0000534 ! organ system morphology variant is_a: WBPhenotype:0000575 ! organ system physiology variant is_a: WBPhenotype:0001739 ! aging variant [Term] id: WBPhenotype:0001741 name: spontaneous spicule protraction def: "Males exhibit spicule-muscle seizures leading to inappropriately timed protraction compared to control." [WB:WBPaper00032000, WB:WBPerson712] synonym: "precocious spicule protraction" RELATED [] is_a: WBPhenotype:0000279 ! spicule insertion defective [Term] id: WBPhenotype:0001742 name: lipid synthesis increased def: "The endogenous anabolism of any lipid species has been increased compared to that observed in control animals." [WB:WBPaper00032082, WB:WBPerson712] is_a: WBPhenotype:0000725 ! lipid metabolism variant [Term] id: WBPhenotype:0001743 name: mitosis variant def: "Any variation in the division of the eukaryotic cell nucleus to produce two daughter nuclei that contain the identical chromosome complement of their mother compared to control." [GO:0007067, WB:WBPerson557] synonym: "mitosis abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell division variant [Term] id: WBPhenotype:0001744 name: cell adhesion variant def: "Any variation in the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix compared to control." [GO:0007155, WB:WBPerson557] synonym: "cell adhesion abnormal" NARROW [] is_a: WBPhenotype:0001657 ! cell junction variant [Term] id: WBPhenotype:0001745 name: adherens junction variant def: "Any variation in a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control." [GO:0005912, WB:WBPerson557] synonym: "adherens junction abnormal" NARROW [] is_a: WBPhenotype:0001658 ! intercellular junction variant [Term] id: WBPhenotype:0001746 name: tight junction defective def: "Any perturbation in the belt-like region of very close contact between the plasma membranes of adjacent cells that results in the complete occlusion of the intercellular space." [GO:0005923, WB:WBPerson557] synonym: "tight junction abnormal" NARROW [] synonym: "zonula occludens abnormal" EXACT [] is_a: WBPhenotype:0001658 ! intercellular junction variant [Term] id: WBPhenotype:0001747 name: zinc response variant def: "Animals exhibit variations in the change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus compared to control." [GO:0010043, WB:WBPerson712] synonym: "zinc response abnormal" NARROW [] is_a: WBPhenotype:0000591 ! metal response variant [Term] id: WBPhenotype:0001748 name: pharynx unattached def: "The pharynx is detached from the mouth." [WB:WBPaper00031910, WB:WBPerson712] synonym: "Pun" EXACT [] is_a: WBPhenotype:0000707 ! pharyngeal development variant [Term] id: WBPhenotype:0001749 name: zinc toxicity hypersensitive def: "The toxic response to zinc occurs at a lower concentration or a shorter exposure compared to control animals. In C. elegans hypersensitive animals exhibit delayed development or lethality at concentrations of zinc (e.g. ZnSO4), which has little or no effect on control worms." [WB:WBPaper00031911, WB:WBPerson712] is_a: WBPhenotype:0001747 ! zinc response variant [Term] id: WBPhenotype:0001750 name: zinc toxicity resistant def: "Animals fail to exhibit toxicity to the concentration of zinc that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to zinc include delayed development or lethality." [WB:WBPaper00031911, WB:WBPerson712] is_a: WBPhenotype:0001747 ! zinc response variant [Term] id: WBPhenotype:0001751 name: organism hypertonic lethality increased def: "Animals exhibit increased lethality as a result of exposure to environments with a higher solute concentration than their own internal environment, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "Hos" RELATED [] synonym: "hypertonic sensitive" RELATED [] is_a: WBPhenotype:0000141 ! stress induced lethality increased is_a: WBPhenotype:0000876 ! organism osmotic stress response variant [Term] id: WBPhenotype:0001752 name: vesicle trafficking variant def: "Animals exhibit variations in vesicle-based directed movement of substances into, out of, or within a cell compared to control." [GO:0016192, WB:WBPerson712] synonym: "vesicle trafficking abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0001753 name: coelomocyte uptake increased def: "Animals exhibit intensified accumulation of fluids or fluorescent markers etc. within their coelomocytes compared to control animals." [WB:WBPaper00004883, WB:WBPerson712] is_a: WBPhenotype:0001426 ! coelomocyte uptake defective [Term] id: WBPhenotype:0001754 name: endosome to lysosome trafficking defective def: "Contents of endosomes fail to be transported to lysosomal compartments." [WB:WBPaper00029049, WB:WBPerson712] is_a: WBPhenotype:0001421 ! endocytic transport variant [Term] id: WBPhenotype:0001755 name: UV induced mitotic germ cell arrest defective def: "Animals do not arrest mitotic germ cell division, as control animals, when treated with UV radiation." [WB:WBPaper00028948, WB:WBPerson557] is_a: WBPhenotype:0000100 ! cell UV response variant [Term] id: WBPhenotype:0001756 name: UV induced apoptosis decreased def: "Programmed cell death caused by UV radiation is reduced compared to control animals. In C. elegans, this is often measured in the pachytene region of the gonad." [WB:WBPaper00028948, WB:WBPerson557] is_a: WBPhenotype:0000100 ! cell UV response variant [Term] id: WBPhenotype:0001757 name: neuropeptide metabolism variant def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of signalling peptides in the organism compared to control." [WB:WBPerson712] synonym: "neuropeptide metabolism abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0001758 name: neuropeptide processing variant def: "Variations in the chemical reactions and pathways involved in the formation and maturation of specialized peptidergic neurotransmitters encoded as preproproteins that are posttranslationally processed to yield bioactive neuropeptides compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuropeptide processing abnormal" NARROW [] is_a: WBPhenotype:0000122 ! post translational processing variant is_a: WBPhenotype:0001757 ! neuropeptide metabolism variant [Term] id: WBPhenotype:0001759 name: 21U RNA expression variant def: "Variations in the biogenesis or stability of the 21U-RNA class of molecules compared to control. Molecules are classified as 21U-RNA based on the presence of a 5'U and a conserved upstream motif, which may specify the production of these molecules, in addition these molecules are typically 21nt in length." [GO:0016070, WB:WBPaper00028915, WB:WBPaper00031962, WB:WBPerson712] synonym: "21U RNA expression abnormal" NARROW [] synonym: "piRNA expression abnormal" RELATED [] is_a: WBPhenotype:0000113 ! RNA expression variant [Term] id: WBPhenotype:0001760 name: G tract instability def: "Animals exhibit an increase in the rate of deletion events in mono-G or G-rich tracts within the genome compared to control." [WB:WBPaper00031945, WB:WBPerson712] is_a: WBPhenotype:0000000 ! chromosome instability [Term] id: WBPhenotype:0001761 name: axon midline crossing variant def: "Regulated ventral midline crossing by axons vary either in the frequency of crossing events or the maintenance through development of process positions compared to control." [GO:0016199, WB:WBPaper00032007, WB:WBPerson712] synonym: "axon midline crossing abnormal" NARROW [] is_a: WBPhenotype:0000384 ! axon guidance variant [Term] id: WBPhenotype:0001762 name: uptake of yolk defective def: "Yolk is not taken up by oocytes in the same manner or to the same degree as observed for control animals. This often leads to an accumulation of yolk in the pseudocoelom." [WB:WBPaper00003831, WB:WBPerson712] is_a: WBPhenotype:0001422 ! endocytic transport defect is_a: WBPhenotype:0001424 ! oocyte physiology variant [Term] id: WBPhenotype:0001763 name: uptake by intestinal cell defective def: "Uptake of subtances from the intestine is altered from that observed in control animals." [WB:WBPaper00004883, WB:WBPerson712] is_a: WBPhenotype:0000986 ! epithelial cell physiology variant is_a: WBPhenotype:0001422 ! endocytic transport defect [Term] id: WBPhenotype:0001764 name: carbon dioxide response variant def: "Animals exhibit variations in their response to carbon dioxide compared to control." [WB:WBPerson712] synonym: "carbon dioxide response abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0001765 name: carbon dioxide avoidance variant def: "Variations in the characteristic movement away from specific CO2 levels compared to control. C. elegans avoids high levels of CO2." [WB:WBPaper00031935, WB:WBPerson557, WB:WBPerson712] synonym: "carbon dioxide avoidance abnormal" NARROW [] synonym: "Cdad" RELATED [] synonym: "CO2 avoidance abnormal" RELATED [] is_a: WBPhenotype:0001764 ! carbon dioxide response variant [Term] id: WBPhenotype:0001766 name: cholesterol depletion hypersensitive def: "Animals are more sensitive to the reduction of cholesterol in the environment compared to control animals." [GO:0042632, WB:WBPaper00026641, WB:WBPerson712] is_a: WBPhenotype:0000725 ! lipid metabolism variant [Term] id: WBPhenotype:0001767 name: commissure handedness defective def: "Outgrowth of the commissure occurs on the side of the body different from that observed in control animals." [WB:WBPaper00032007, WB:WBPerson712] is_a: WBPhenotype:0000181 ! axon trajectory variant is_a: WBPhenotype:0000384 ! axon guidance variant [Term] id: WBPhenotype:0001768 name: commissure number variant def: "Variations in the quantity of circumferential axonal tracts from the number observed in control animals." [WB:WBPaper00032007, WB:WBPerson712] synonym: "commissure number abnormal" NARROW [] is_a: WBPhenotype:0001226 ! commissure variant [Term] id: WBPhenotype:0001769 name: cytoplasmic RNAi defective def: "Animals fail to silence cytoplasmic-localized RNAs. Nuclear-localized RNAs may still be sensitive to RNAi." [WB:WBPaper00032049, WB:WBPerson712] is_a: WBPhenotype:0000743 ! RNAi response variant [Term] id: WBPhenotype:0001770 name: endo siRNA binding variant def: "Animals exhibit variations in their selective interactions with small interfering RNA molecules compared to control." [GO:0035197, WB:WBPaper00032049, WB:WBPerson712] synonym: "endo siRNA binding abnormal" NARROW [] is_a: WBPhenotype:0000743 ! RNAi response variant [Term] id: WBPhenotype:0001771 name: endo siRNA production variant def: "Animals exhibit variations in the length or amount of any endogenous small interfering RNA molecule populations compared to control." [WB:WBPaper00031932, WB:WBPaper00032049, WB:WBPerson712] synonym: "endo siRNA production abnormal" NARROW [] is_a: WBPhenotype:0000743 ! RNAi response variant [Term] id: WBPhenotype:0001772 name: endogenous transposase levels increased def: "Animals exhibit an increase in the levels of transposase mRNA, from endogenous transposons, over that measured in control animals." [WB:WBPaper00031962, WB:WBPerson712] is_a: WBPhenotype:0000745 ! transposon silencing variant [Term] id: WBPhenotype:0001773 name: enhanced locomotion defective def: "Animals do not exhibit an increase in speed when placed in an environment that relies on a combination of swimming and crawling behaviors compared to control." [WB:WBPaper00031965, WB:WBPerson712] is_a: WBPhenotype:0001206 ! movement variant [Term] id: WBPhenotype:0001774 name: gut on the exterior def: "An epidermal enclosure defect that results in internal organs lying on the outside of the embryo." [WB:WBPaper00005123, WB:WBPaper00032090, WB:WBPerson712] synonym: "Gex" EXACT [] is_a: WBPhenotype:0000047 ! gastrulation variant [Term] id: WBPhenotype:0001775 name: hormetic temperature induced life span extension defective def: "Pre-treatment with stress-inducing temperatures does not result in a life-span extension as it does in control animals." [WB:WBPaper00028750, WB:WBPaper00031942, WB:WBPerson712] is_a: WBPhenotype:0000061 ! extended life span is_a: WBPhenotype:0000146 ! organism temperature response variant [Term] id: WBPhenotype:0001776 name: siRNA expression variant def: "Variations in the biogenesis and stability of the small interfering class of RNA molecules compared to control. In C. elegans these molecules are antisense to mRNA's and may be processed from long double-stranded RNA." [GO:0016070, WB:WBPaper00028915, WB:WBPaper00031962, WB:WBPerson712] synonym: "siRNA expression abnormal" NARROW [] is_a: WBPhenotype:0000113 ! RNA expression variant [Term] id: WBPhenotype:0001777 name: pre mRNA levels increased def: "Animals exhibit an increase in the levels of nuclear mRNA species compared to control." [WB:WBPaper00032049, WB:WBPerson712] is_a: WBPhenotype:0000113 ! RNA expression variant [Term] id: WBPhenotype:0001778 name: nuclear RNAi defective def: "Animals fail to silence nuclear-localized RNAs. Animals still retain sensitivity to RNAi for those RNAs located outside of the nucleus." [WB:WBPaper00032049, WB:WBPerson712] is_a: WBPhenotype:0000743 ! RNAi response variant [Term] id: WBPhenotype:0001779 name: miRNA expression variant def: "Variations in the biogenesis or stability of the microRNA class of molecules compared to control. In C. elegans these molecules are endogenous single-stranded regulatory molecules, 19-25 nucleotides long, with the potential to arise from hairpin, foldback, structures from their primary transcripts." [GO:0035196, WB:WBPaper00028915, WB:WBPaper00029181, WB:WBPaper00030747, WB:WBPaper00031962, WB:WBPerson712] synonym: "miRNA expression abnormal" NARROW [] is_a: WBPhenotype:0000113 ! RNA expression variant [Term] id: WBPhenotype:0001780 name: associative learning variant def: "Variations in the behavioral plasticity induced by the integration of two sensory signals compared to control. In C. elegans animals exhibit enhancement of butanone chemotaxis by preexposure to butanone and food." [WB:WBPaper00029060, WB:WBPerson2021] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0001781 name: hypersensitivity to mutagen def: "Animals are more susceptible than control animals to the effects of a nucleic acid damaging agent. This increased susceptibility is often measured by an increase in the rate of spontaneous mutations or an increased lethality." [WB:WBPaper00031945, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0001782 name: anoxia response attenuated def: "Response to trace levels of oxygen is reduced or weakened compared to the response of control animals." [WB:WBPaper00031981, WB:WBPerson712] is_a: WBPhenotype:0000464 ! oxygen response variant [Term] id: WBPhenotype:0001783 name: ligand gated channel activity variant def: "Animals exhibit variations in the actions of a channel that catalyses the transmembrane transfer of a cation when acetylcholine has been bound by the channel complex or one of its constituent parts compared to control animals." [GO:0022834, WB:WBPaper00031930, WB:WBPerson712] synonym: "ligand gated channel activity abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug response variant is_a: WBPhenotype:0000656 ! acetylcholine synaptic transmission variant is_a: WBPhenotype:0001833 ! membrane trafficking variant [Term] id: WBPhenotype:0001784 name: lysosome homeostasis deficient def: "Animals are deficient in the formation or disassembly of lysosomes." [GO:0007040, WB:WBPaper00029049, WB:WBPerson712] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0001785 name: memory retention defective def: "Animals are deficient in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms." [WB:WBPaper00031974, WB:WBPerson712] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0001786 name: neuronal ion channel clustering defective def: "Animals exhibit variations in the targeting, clustering and or maintenance of ion channels in distinct subcellular domains of the neuron compared to control animals." [GO:0045161, WB:WBPaper00031930, WB:WBPerson712] is_a: WBPhenotype:0000612 ! nervous system physiology variant is_a: WBPhenotype:0000816 ! neuron development variant is_a: WBPhenotype:0000991 ! neuron physiology variant [Term] id: WBPhenotype:0001787 name: phototaxis defective def: "Animals do not respond via directed movement to light stimuli in the same manner as control animals. In C. elegans, animals move away from light." [WB:WBPaper00031999, WB:WBPerson712] is_a: WBPhenotype:0001897 ! light response variant [Term] id: WBPhenotype:0001788 name: resistant to mutagens def: "Animals survive longer than control animals after or during exposure to DNA damaging agents." [WB:WBPaper00031934, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0001789 name: temperature influenced life span variant def: "Life span of the animal is not influenced by changes in temperature in the same manner as control animals." [WB:WBPaper00031942, WB:WBPerson712] synonym: "temperature independent life span" NARROW [] synonym: "temperature influenced life span abnormal" NARROW [] is_a: WBPhenotype:0000039 ! life span variant is_a: WBPhenotype:0000146 ! organism temperature response variant [Term] id: WBPhenotype:0001790 name: thermoreceptor currents absent def: "Cooling or warming evoked changes in membrane currents are not observed." [WB:WBPaper00032060, WB:WBPerson712] synonym: "ThRC absent " RELATED [] is_a: WBPhenotype:0000851 ! ciliated neuron physiology variant [Term] id: WBPhenotype:0001791 name: defecation cycle temperature compensation variant def: "Animals exhibit variations in temperature dependent differences in the length of their defecation cycle. In C. elegans the length of the cycle is the same at different temperatures, showing temperature compensation." [WB:WBPaper00002315, WB:WBPerson712] synonym: "defecation cycle temperature compensation abnormal" NARROW [] is_a: WBPhenotype:0000207 ! defecation cycle variant [Term] id: WBPhenotype:0001792 name: nuclei small def: "Nuclei of specific cells are smaller compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001028 ! nuclear appearance variant [Term] id: WBPhenotype:0001793 name: aboc expulsion missing def: "The anterior body contraction and expulsion steps of the defecation cycle are absent; posterior body contractions are still present." [WB:WBPaper00002776, WB:WBPerson712] synonym: "Aex" RELATED [] is_a: WBPhenotype:0000391 ! defecation missing motor steps [Term] id: WBPhenotype:0001794 name: cytoplasmic processing body variant def: "Discrete foci within the cytoplasm containing congregations of mRNA translational suppression and degradation mechanisms vary in their arrangement, clustering or are otherwise not well-defined compared to control." [WB:WBPaper00031914, WB:WBPaper00032172, WB:WBPerson712] synonym: "cytoplasmic processing body abnormal" NARROW [] synonym: "P body abnormal" RELATED [] is_a: WBPhenotype:0001300 ! germ cell cytoplasmic morphology variant [Term] id: WBPhenotype:0001795 name: microsatellite instability def: "Animals exhibit variations in repeat lengths of microsatellite genomic sequences compared to control." [WB:WBPaper00031859, WB:WBPerson712] is_a: WBPhenotype:0000000 ! chromosome instability [Term] id: WBPhenotype:0001796 name: organism hypersensitive interstrand cross link agents def: "Animals exhibit increased sensitivity to interstrand cross-linking agents, such as HN2 (nitrogen mustard) and CDDP (cisplatin) compared to control. In C. elegans, increased sensitivity to these agents is often observed as a decrease in survival compared to control animals after exposure to the agent." [WB:WBPaper00031868, WB:WBPerson712] synonym: "interstrand cross link agent hypersensitive" RELATED [] is_a: WBPhenotype:0000067 ! organism stress response variant [Term] id: WBPhenotype:0001797 name: pachytene arrested germline nuclei def: "Germline nuclei do not progress through pachytene to diplotene." [WB:WBPaper00031914, WB:WBPerson712] is_a: WBPhenotype:0001946 ! pachytene progression during oogenesis variant [Term] id: WBPhenotype:0001798 name: inhibition of synaptogenesis defective def: "The processes that inhibit the location or frequency of formation of synapses are downregulated resulting in the formation of synapses or synapse-like structures in areas of the neuron that are typically devoid of synapses in control animals." [GO:0051964, WB:WBPaper00032163, WB:WBPerson712] is_a: WBPhenotype:0000625 ! synaptogenesis variant is_a: WBPhenotype:0000944 ! neurite development variant [Term] id: WBPhenotype:0001799 name: inhibition of synaptogenesis hyperactive def: "The processes that inhibit the location or frequency of formation of synapses are upregulated compared to control." [GO:0051964, WB:WBPaper00032163, WB:WBPerson712] is_a: WBPhenotype:0000944 ! neurite development variant [Term] id: WBPhenotype:0001800 name: antimicrobial gene expression variant def: "Changes in the levels of innate immune gene products in response to pathogen exposure are significantly different from that observed in control animals." [WB:WBPaper00031865, WB:WBPerson712] synonym: "antimicrobial gene expression abnormal" NARROW [] is_a: WBPhenotype:0002164 ! innate immune response variant [Term] id: WBPhenotype:0001801 name: axodendritic polarity variant def: "Animals fail to establish or maintain characteristics that delineate the dendrite from the axon. The exclusion of presynaptic components from the dendrite is one indication of axodendritic polarity." [WB:WBPaper00032163, WB:WBPerson712] synonym: "axodendritic polarity abnormal" NARROW [] is_a: WBPhenotype:0000944 ! neurite development variant [Term] id: WBPhenotype:0001802 name: body wall muscle relaxation defective def: "Animals fail to relax their body wall muscles to the same extent as muscles in control animals." [WB:WBPaper00032190, WB:WBPerson712] is_a: WBPhenotype:0000596 ! body behavior variant [Term] id: WBPhenotype:0001803 name: endosome biogenesis variant def: "Animals exhibit variations in the formation or disassembly of membrane bound organelles that traffic material between the plasma membrane and internal compartments of the cell, compared to control." [WB:WBPaper00032168, WB:WBPerson712] synonym: "endosome biogenesis abnormal" NARROW [] is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant [Term] id: WBPhenotype:0001804 name: fat associated bodies reduced def: "Animals exhibit a decrease in the number of fat containing organelles compared to control. In C. elegans this number can be assayed by decreases in the number of Nile Red or BODIPY 493/503 staining bodies." [WB:WBPaper00032168, WB:WBPerson712] is_a: WBPhenotype:0001901 ! fat associated bodies variant [Term] id: WBPhenotype:0001805 name: mitochondria vesiculated def: "Inner membrane of mitochondria are disconnected and form vesicular bodies." [GO:0007005, WB:WBPaper00032231, WB:WBPerson712] is_a: WBPhenotype:0001401 ! mitochondria morphology variant [Term] id: WBPhenotype:0001806 name: protein stabilization variant def: "Any variation in the ability of a protein to resist disintegration via chemical or physical modifications compared to control." [WB:WBPaper00029085, WB:WBPerson2021] synonym: "protein stabilization abnormal" NARROW [] is_a: WBPhenotype:0001644 ! protein metabolism variant [Term] id: WBPhenotype:0001807 name: alternative splicing variant def: "Any variation in the process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition compared to control." [GO:0000380, WB:WBPerson557] synonym: "alternative splicing abnormal" NARROW [] is_a: WBPhenotype:0000028 ! RNA processing variant [Term] id: WBPhenotype:0001808 name: cell corpse digestion variant def: "The degradation of genomic and or cellular material of the corpse does not occur at the same rate or under the same conditions as observed in control animals undergoing cell death." [WB:WBPaper00032272, WB:WBPerson712] synonym: "cell corpse digestion abnormal" NARROW [] is_a: WBPhenotype:0000885 ! engulfment variant [Term] id: WBPhenotype:0001809 name: organelle fusion defective def: "The formation of mature intracellular compartments via membrane fusion is disrupted." [WB:WBPaper00032272, WB:WBPerson712] is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant [Term] id: WBPhenotype:0001810 name: oocyte septum formation variant def: "Animals exhibit variations in the partitioning of oocytes from each other compared to control animals." [WB:WBPaper00028947] synonym: "oocyte cellularization defective" RELATED [] synonym: "oocyte partition variant" RELATED [] synonym: "oocyte septum formation abnormal" NARROW [] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0001811 name: serotonin induced fat reduction variant def: "Animals retain a significantly greater proportion of their fat upon serotonin treatment, compared to control." [WB:WBPaper00031915, WB:WBPerson2021] synonym: "serotonin induced fat reduction abnormal" NARROW [] synonym: "serotonin induced fat regulation" RELATED [] is_a: WBPhenotype:0000024 ! serotonin resistant is_a: WBPhenotype:0001232 ! serotonin response variant [Term] id: WBPhenotype:0001812 name: embryonic rupture def: "During development of the embryo, the epidermis loses integrity and the contents of the embryo are expelled." [WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0001813 name: synapsis defective def: "Animals exhibit defects in the stabilization of homologue pairing, which occurs through the initiation and formation of the synaptonemal complex, during meiosis." [WB:WBPaper00032296, WB:WBPerson712] is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0001814 name: crossover defective def: "Animals exhibit defects in the number or extent of connections between chromatids that occur during the process of genetic material exchange between homologous segments of non-sister chromatids." [GO:0051026, WB:WBPaper00032296, WB:WBPerson712] synonym: "chiasma defective" RELATED [] synonym: "homologous recombination foci variant" RELATED [] is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0001815 name: desynapsis defective def: "Animals exhibit defects in the asymmetric diassembly of the synaptonemal complex during progression through meiosis." [WB:WBPaper00032296, WB:WBPerson712] is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0001816 name: egg laying circuit variant def: "Neuromuscular signaling between neurons and egg laying musculature varies from that observed for control animals." [WB:WBPaper00032221, WB:WBPerson712] synonym: "egg laying circuit abnormal" NARROW [] is_a: WBPhenotype:0000929 ! hermaphrodite physiology variant [Term] id: WBPhenotype:0001817 name: enhanced taste aversion defective def: "The conditioned aversion to a specific chemical compound as a result of that compound being coupled with an unfavorable condition, such as starvation, does not increase to the same extent as observed for control animals." [WB:WBPaper00032335, WB:WBPerson712] synonym: "enhanced gustatory plasticity defective" RELATED [] synonym: "enhanced taste aversion defective" RELATED [] synonym: "starvation enhanced taste aversion defective" RELATED [] is_a: WBPhenotype:0000147 ! organism starvation response variant is_a: WBPhenotype:0001444 ! aqueous adaptation defective [Term] id: WBPhenotype:0001818 name: neuron activation variant def: "Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes." [WB:WBPaper00032221, WB:WBPerson712] synonym: "neuron activation abnormal" NARROW [] synonym: "neuron activity abnormal" RELATED [] is_a: WBPhenotype:0000991 ! neuron physiology variant [Term] id: WBPhenotype:0001819 name: pathogen load variant def: "The number of pathogens associated with the animal vary from that associated with control animals." [WB:WBPaper00032196, WB:WBPerson712] synonym: "bacterial load variant " NARROW [] is_a: WBPhenotype:0001012 ! organism pathogen response variant [Term] id: WBPhenotype:0001820 name: bordering def: "Animals tend to accumulate at the thickest part of the bacterial lawn." [WB:WBPaper00003187, WB:WBPaper00032342, WB:WBPerson712] synonym: "bordering increased" RELATED [] is_a: WBPhenotype:0000662 ! foraging behavior variant is_a: WBPhenotype:0001291 ! social behavior variant [Term] id: WBPhenotype:0001821 name: non bordering def: "Animals do not accumulate at the thickest part of the bacterial lawn. Animals do not preferentially deplete bacterial food at the thicker parts of the lawn." [WB:WBPaper00032342, WB:WBPerson712] is_a: WBPhenotype:0000662 ! foraging behavior variant is_a: WBPhenotype:0001291 ! social behavior variant [Term] id: WBPhenotype:0001822 name: dauer pheromone secretion variant def: "Animals produce pheromone but it does not undergo controlled release into the environment." [WB:WBPaper00032517, WB:WBPerson712] is_a: WBPhenotype:0000258 ! cell secretion variant is_a: WBPhenotype:0000609 ! excretory secretory system physiology variant [Term] id: WBPhenotype:0001823 name: sperm recruitment variant def: "Any variation in the mechanism by which sperm find their correct target destinations (spermatheca)." [WB:WBPaper00028527, WB:WBPerson2021] is_a: WBPhenotype:0001424 ! oocyte physiology variant [Term] id: WBPhenotype:0001824 name: meiotic progression prophase variant def: "Animals exhibit variations in any process necessary for the progression through prophase during meiosis compared to control animals." [WB:WBPaper00005486, WB:WBPerson557] is_a: WBPhenotype:0000313 ! meiotic progression during oogenesis variant is_a: WBPhenotype:0000775 ! meiosis variant [Term] id: WBPhenotype:0001825 name: rudimentary gonad def: "Animals have very few or no germline nuclei and gonad arms that are very small or missing." [WB:WBPaper00005486, WB:WBPerson557] is_a: WBPhenotype:0001355 ! gonad morphology variant [Term] id: WBPhenotype:0001826 name: RNA degradation variant def: "Variations in the regulated breakdown of RNA species via the action of cellular enzymes (RNases) compared to control." [WB:WBPaper00032091, WB:WBPerson2021] is_a: WBPhenotype:0000028 ! RNA processing variant [Term] id: WBPhenotype:0001827 name: RNA metabolism variant def: "Variations in any process that involves the maintenance, biosynthesis or accumulation of RNA in the organism compared to control." [WB:WBPaper00004325, WB:WBPerson2021] is_a: WBPhenotype:0000585 ! cell homeostasis metabolism variant [Term] id: WBPhenotype:0001828 name: RNAi persistence variant def: "Variations in the persistence of an RNAi induced phenotype compared to control." [WB:WBPaper00004325, WB:WBPerson2021] is_a: WBPhenotype:0000743 ! RNAi response variant [Term] id: WBPhenotype:0001829 name: premature spermatid activation def: "Any variation that results in the premature differentiation of spermatids into motile spermatozoa compared to control." [WB:WBPaper00033007, WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis variant [Term] id: WBPhenotype:0001830 name: response to multiple stressors variant def: "Any variation in an animal's response to exposure to multiple stressors occuring simultaneously or during an overlapping temporal window compared to control." [WB:WBPaper00031874, WB:WBPerson2021] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0001831 name: intestinal microvilli variant def: "Any variation in the formation of intestinal microvilli. Microvilli are actin-based cellular structures that form plasma membrane projections into the extracellular space and whose specialized shape provides increased cellular surface area. Microvilli are a crucial component of the terminal differentiation process for many epithelial cell types, usually ones that play an absorptive or filtering role." [WB:WBPaper00025171, WB:WBPerson557] is_a: WBPhenotype:0000705 ! intestinal cell development variant [Term] id: WBPhenotype:0001832 name: nuclear pore variant def: "Any variation that disrupts the assembly, distribution, localization or organization of any of the numerous similar discrete openings in the nuclear envelope, where the inner and outer nuclear membranes are joined." [GO:0005643, WB:WBPerson557] is_a: WBPhenotype:0001138 ! nucleus defective early emb [Term] id: WBPhenotype:0001833 name: membrane trafficking variant def: "Any variation in the directed movement of substances in a cell, from one side of a membrane to another, compared to control." [GO:0005215, WB:WBPaper00025137, WB:WBPerson2021] synonym: "membrane transport variant" RELATED [] synonym: "transporter activity variant" RELATED [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0001834 name: mRNA splicing variant def: "Variations in the processes regulating the excision of intervening introns from the primary mRNA transcript, compared to control." [GO:0008380, WB:WBPaper00032287, WB:WBPerson2021] is_a: WBPhenotype:0000028 ! RNA processing variant [Term] id: WBPhenotype:0001835 name: energy expenditure variant def: "Variations in the amount of energy consumed by an organism compared to control. Energy expenditure is often determined by assaying oxygen consumption." [WB:WBPaper00032936, WB:WBPerson2021] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0001836 name: eggshell morphology variant def: "Any variation in the overall structure or appearance of the protective barrier which isolates the embryo from the external environment, compared to control ." [WB:WBPaper00033072, WB:WBPerson2021] is_a: WBPhenotype:0000037 ! egg morphology variant [Term] id: WBPhenotype:0001837 name: diet induced life span variant def: "Life span of the animal is not influenced by changes in diet in the same manner as control animals." [WB:WBPaper00032936, WB:WBPerson2021] is_a: WBPhenotype:0000039 ! life span variant [Term] id: WBPhenotype:0001838 name: drug induced gene expression variant def: "Gene expression of an animal is not influenced by drug treatment in the same manner as control animals." [WB:WBPaper00033094, WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene expression variant [Term] id: WBPhenotype:0001839 name: phorbol ester resistant def: "Animals fail to respond to the concentration of phorbol esters that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Phorbol esters such as PMA act as DAG mimetics." [WB:WBPaper00033094, WB:WBPerson2021] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0001840 name: response to injury variant def: "Variations in the processes that restore integrity to a damaged tissue following an injury, compared to control." [GO:0042060, WB:WBPaper00033094, WB:WBPerson2021] synonym: "wound healing variant" RELATED [] is_a: WBPhenotype:0000142 ! cell stress response variant [Term] id: WBPhenotype:0001841 name: second messenger mediated signaling variant def: "Any variation in a series of molecular signals that help relay a receptor mediated signal within the cell, compared to control. Second messengers often comprise of ions (eg: Ca2+) or small molecules (cGMP, cAMP etc) that are formed or released into the cytosol." [GO:0019932, WB:WBPaper00033456, WB:WBPerson2021] is_a: WBPhenotype:0000463 ! metabolic pathway variant [Term] id: WBPhenotype:0001842 name: drug withdrawal response variant def: "Any variation in the state or activity of an organism as a result of abrupt discontinuation or decreased dosage of a drug, compared to control." [WB:WBPaper00033168, WB:WBPerson2021] synonym: "rebound response defective" RELATED [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001843 name: hormone metabolism variant def: "Animals exhibit variations in any process that involves the degradation, biosynthesis or accumulation of hormones within the organism compared to control. Hormones are naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [GO:0042445, WB:WBPaper00034639, WB:WBPerson2021] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0001844 name: lipid hydrolysis regulation variant def: "Variations in the process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids, compared to control." [GO:0050994, WB:WBPaper00033126, WB:WBPerson2021] synonym: "fat granule regulated breakdown variant" RELATED [] synonym: "fat granule regulated hydrolysis variant " RELATED [] synonym: "lipid lysis regulation variant" RELATED [] synonym: "regulation of lipid catabolic process variant" RELATED [] is_a: WBPhenotype:0000725 ! lipid metabolism variant [Term] id: WBPhenotype:0001845 name: lipid modification variant def: "Variations in the covalent alteration of one or more components (eg: fatty acids, sterols etc.) in a lipid, resulting in a change in the properties of the lipid, compared to control." [GO:0030258, WB:WBPaper00034639, WB:WBPerson2021] is_a: WBPhenotype:0000725 ! lipid metabolism variant [Term] id: WBPhenotype:0001846 name: phagosome maturation defective def: "Early phagosomes fail to undergo the maturation process following the ingestion of particulate material by phagocytosis; During maturation, phagosomes acquire markers of late endosomes and lysosomes." [GO:0001845, WB:WBPaper00031805, WB:WBPerson2021] is_a: WBPhenotype:0000885 ! engulfment variant [Term] id: WBPhenotype:0001847 name: sterol induced dauer formation variant def: "Variations in the processes that facilitate/permit dauer entry when exposed to specific sterol molecules, compared to control." [WB:WBPaper00034639, WB:WBPerson2021] is_a: WBPhenotype:0001539 ! dauer induction variant [Term] id: WBPhenotype:0001848 name: tube morphogenesis variant def: "Variations in the process by which the anatomical structures of a tube are generated and organized, compared to control. Morphogenesis pertains to the creation of form or shape." [GO:0035239, WB:WBPaper00033081, WB:WBPerson2021] synonym: "tubulogenesis variant" RELATED [] is_a: WBPhenotype:0000530 ! organ system development variant [Term] id: WBPhenotype:0001849 name: zinc homeostasis variant def: "Variations in the regulation of levels, transport, and metabolism of zinc ions within an organism compared to control." [GO:0006882, WB:WBPaper00033166, WB:WBPerson2021] is_a: WBPhenotype:0002029 ! metal homeostasis variant [Term] id: WBPhenotype:0001850 name: radiation induced germ cell apoptosis resistant def: "Programmed cell death of germ cells caused by exposure to ionizing energy does not occur to the same extent as it does in control animals." [WB:WBPaper00032006, WB:WBPaper00032243, WB:WBPaper00032356, WB:WBPerson712] is_a: WBPhenotype:0000737 ! germ cell resistant ionizing radiation is_a: WBPhenotype:0002152 ! mutagen induced apoptosis variant [Term] id: WBPhenotype:0001851 name: radiation induced reproductive cell death variant def: "Animals exhibit variations in radiation induced non-apoptotic death of multipotential precursor cells or tissues (clonogens) compared to control. Elimination of clonogens results in normal tissue damage as well as solid-tumor eradication." [WB:WBPaper00027700, WB:WBPerson2021] is_a: WBPhenotype:0001173 ! non apoptotic cell death variant is_a: WBPhenotype:0001268 ! induced cell death variant [Term] id: WBPhenotype:0001852 name: antihelmintic response variant def: "Animals exhibit variations in their response to an agent that destroys or causes the expulsion of parasitic intestinal worms compared to that observed in control animals." [WB:WBPaper00035074, WB:WBPerson2021] is_a: WBPhenotype:0000459 ! pesticide response variant [Term] id: WBPhenotype:0001853 name: AAD response variant def: "Animals exhibit variations in their response to the amino-acetonitrile derivatives (AADs) class of synthetic anthelmintics, compared to that observed in control animals." [WB:WBPaper00035150, WB:WBPerson2021] is_a: WBPhenotype:0001852 ! antihelmintic response variant [Term] id: WBPhenotype:0001854 name: benomyl response variant def: "Animals exhibit variations in their response to the microtubule-depolymerizing drug benomyl, compared to that observed in control animals." [WB:WBPaper00035150, WB:WBPerson2021] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001855 name: fluoride resistant def: "Animals fail to respond to the concentration of fluoride ions that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to fluoride ions to elicit the response compared to control animals." [WB:WBPaper00035174, WB:WBPerson2021] is_a: WBPhenotype:0001502 ! chemical resistant [Term] id: WBPhenotype:0001856 name: ivermectin response variant def: "Animals exhibit variations in their response to ivermectin, an agonist of glutamate-gated chloride channels, compared to that observed in control animals." [WB:WBPaper00035150, WB:WBPaper00035194, WB:WBPerson2021] is_a: WBPhenotype:0000631 ! drug response variant is_a: WBPhenotype:0001852 ! antihelmintic response variant [Term] id: WBPhenotype:0001857 name: pathogen induced gene expression variant def: "Gene expression of an animal is not influenced by the exposure to disease causing agents in the same manner as control animals." [WB:WBPaper00035315, WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene expression variant is_a: WBPhenotype:0001012 ! organism pathogen response variant [Term] id: WBPhenotype:0001858 name: suppression of head oscillations defective def: "Animals fail to suppress head oscillations in response to anterior touch. In C. elegans, this behavior is a result of tyraminergic signaling." [WB:WBPaper00031692, WB:WBPaper00034683, WB:WBPerson2021] synonym: "Sho" RELATED [WB:WBPaper00025096] is_a: WBPhenotype:0000595 ! head behavior variant [Term] id: WBPhenotype:0001859 name: Dosage compensation complex assembly variant def: "Any variation in the aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes, compared to control." [GO:0042714, WB:WBPaper00035328, WB:WBPerson2021] comment: Possible xp. synonym: "DCC localization variant" RELATED [] is_a: WBPhenotype:0000718 ! dosage compensation variant [Term] id: WBPhenotype:0001860 name: endocytic recycling defective def: "Variations in the directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport, compared to control." [GO:0032456, WB:WBPaper00035466, WB:WBPerson2021] is_a: WBPhenotype:0001422 ! endocytic transport defect [Term] id: WBPhenotype:0001861 name: environmental stimuli induced gene expression variant def: "Gene expression of an animal is not influenced by environmental changes in the same manner as control animals." [WB:WBPaper00035435, WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene expression variant [Term] id: WBPhenotype:0001862 name: manganese homeostasis variant def: "Variations in the regulation of levels, transport, and metabolism of manganese ions within an organism compared to control." [GO:0030026, WB:WBPaper00035485, WB:WBPerson2021] comment: Possible XP. is_a: WBPhenotype:0002029 ! metal homeostasis variant [Term] id: WBPhenotype:0001863 name: manganese response variant def: "Animals exhibit variations in their response to manganese compared to that observed in control animals." [GO:0010042, WB:WBPaper00035485, WB:WBPerson2021] comment: Possible XP. is_a: WBPhenotype:0000591 ! metal response variant [Term] id: WBPhenotype:0001864 name: protein transport variant def: "Any variation in the processes that modulate the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore compared to control." [GO:0051223, WB:WBPaper00035491, WB:WBPerson2021] comment: Possible XP. is_a: WBPhenotype:0001644 ! protein metabolism variant is_a: WBPhenotype:0001833 ! membrane trafficking variant [Term] id: WBPhenotype:0001865 name: protein ubiquitination variant def: "Variations in the process by which one or more ubiquitin moieties are added to a protein, compared to control." [GO:0016567, WB:WBPaper00035602, WB:WBPerson2021] comment: Possible XP. is_a: WBPhenotype:0001382 ! protein modification variant [Term] id: WBPhenotype:0001866 name: reduced pathogen accumulation def: "Animals exhibit a reduction in pathogen accumulation, persistent colonization, and luminal distension of the intestine." [GO:0009617, GO:0045087, WB:WBPaper00035215, WB:WBPerson2987] synonym: "Rpa" RELATED [] is_a: WBPhenotype:0001819 ! pathogen load variant [Term] id: WBPhenotype:0001867 name: mitotic spindle asters defective early emb def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle asters during a mitotic cell cycle." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0001102 ! mitotic spindle defective early emb is_a: WBPhenotype:0001110 ! aster defective early emb [Term] id: WBPhenotype:0001868 name: meiotic spindle defective def: "Cells undergoing meiosis exhibit defects in the overall function or activity of the meiotic spindle." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0000775 ! meiosis variant [Term] id: WBPhenotype:0001869 name: meiotic spindle positioning defective def: "Cells undergoing meiosis exhibit defects in the positioning of the meiotic spindle." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0001868 ! meiotic spindle defective [Term] id: WBPhenotype:0001870 name: meiotic spindle rotation defective def: "Cells undergoing meiosis exhibit defects in the rotation of the meiotic spindle." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0001868 ! meiotic spindle defective [Term] id: WBPhenotype:0001871 name: drug induced life span variant def: "Life span of the animal is not influenced by drug exposure in the same manner as control animals." [WB:WBPaper00035656, WB:WBPerson2021] is_a: WBPhenotype:0000039 ! life span variant is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001872 name: drug induced locomotion variant def: "Locomotion of the animal is not influenced by drug exposure in the same manner as control animals." [WB:WBPaper00035656, WB:WBPerson2021] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001873 name: meiotic spindle assembly defective def: "Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the meiotic spindle, the array of microtubules and associated molecules that serves to move duplicated and/or homologous chromosomes apart." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0001868 ! meiotic spindle defective [Term] id: WBPhenotype:0001874 name: protein neddylation variant def: "Any variation in the conjugation of the ubiquitin-like protein Nedd8 to another protein compared to control." [GO:0045116, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP. is_a: WBPhenotype:0001382 ! protein modification variant [Term] id: WBPhenotype:0001875 name: anaphase bridging def: "Chromosomal masses fail to fully separate and remained linked during anaphase." [WB:WBPerson2021, WB:WBPerson557] synonym: "chromosome bridging" RELATED [] synonym: "lagging chromatin" RELATED [] is_a: WBPhenotype:0001378 ! mitotic chromosome segregation variant [Term] id: WBPhenotype:0001876 name: centriole biogenesis variant def: "Any variation in the formation or disassembly of the cylindrical structures that are composed of groupings of microtubules found close to the nucleus (centrioles) compared to control. Centrioles are arranged perpendicularly and are surrounded by an amorphous mass of dense material (the pericentriolar material). The centrioles and the pericentriolar material constitute the compound structure known as the centrosome." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001903 ! centrosome biogenesis variant [Term] id: WBPhenotype:0001877 name: nuclear membrane morphology variant def: "Any variation in the structure, form or composition of the membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated, compared to control." [GO:0005634, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0002037 ! nuclear envelope organization variant [Term] id: WBPhenotype:0001878 name: hydroxyurea response variant def: "Animals exhibit variations in the response to the addition of hydroxyurea compared to that observed in control animals. Hydroxyurea stops DNA from being replicated." [WB:WBPerson2021, WB:WBPerson557] synonym: "HU response variant" RELATED [] synonym: "hydroxycarbamide response variant" RELATED [] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0001879 name: hydroxyurea hypersensitive def: "Animals respond to hydroxyurea at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive is_a: WBPhenotype:0001878 ! hydroxyurea response variant [Term] id: WBPhenotype:0001880 name: endoplasmic reticulum morphology variant def: "Any variation in the form, structure or composition of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GO:0005783, WB:WBPaper00025163, WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0001881 name: endoplasmic reticulum symmetry variant early emb def: "Any variation in the normally asymmetric distribution of the endoplasmic reticulum during cell divisions of the early embryo. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [WB:WBPaper00025163, WB:WBPerson2987] is_a: WBPhenotype:0001880 ! endoplasmic reticulum morphology variant [Term] id: WBPhenotype:0001882 name: aneuploidy def: "Any variation in the number of chromosomes in a cell compared to control." [WB:WBPaper00032450, WB:WBPerson2987] is_a: WBPhenotype:0000773 ! chromosome segregation variant [Term] id: WBPhenotype:0001885 name: cleavage furrow initiation defective early emb def: "Embryos exhibit defects in the formation of the groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [WB:WBPaper00024200, WB:WBPerson2987] is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb [Term] id: WBPhenotype:0001886 name: cleavage furrow termination defective early emb def: "Embryos exhibit defects in the maintenance or termination of the groove in the cell surface near the old metaphase plate during cytokinesis." [WB:WBPaper00024200, WB:WBPerson2987] is_a: WBPhenotype:0001129 ! cleavage furrow defective early emb [Term] id: WBPhenotype:0001887 name: excess seam cells def: "Animals execute supernumerary cell divisions during the development of the lateral, alae-producing epithelial cells, resulting in a larger number of these cells than control animals." [WB:WBPaper00032974, WB:WBPerson2987] is_a: WBPhenotype:0000701 ! epithelial development variant [Term] id: WBPhenotype:0001888 name: fat associated bodies increased def: "Animals exhibit an increase in the number of fat containing organelles compared to control. In C. elegans this number can be assayed by increases in the number of BODIPY 493/503 staining." [WB:WBPaper00035972, WB:WBPerson2021] synonym: "lipid droplet expansion" RELATED [] is_a: WBPhenotype:0001901 ! fat associated bodies variant [Term] id: WBPhenotype:0001889 name: body wall muscle sarcomere morphology variant def: "Any variation in the form, structure or composition of the repeating units of a myofibrils in a muscle cell that are composed of an array of overlapping thick and thin filaments, compared to control." [GO:0030017, WB:WBPerson557] is_a: WBPhenotype:0000926 ! body wall muscle morphology variant [Term] id: WBPhenotype:0001890 name: body wall muscle dense body variant def: "Any variation in the attachment plaque for thin filaments onto the cell membrane. The dense body in body wall muscles is especially large, indenting far into the cytoplasm to border each sarcomere, thus providing a long row of coherent attachment sites at regular intervals (WormAtlas)." [WB:WBPerson557] is_a: WBPhenotype:0001889 ! body wall muscle sarcomere morphology variant [Term] id: WBPhenotype:0001891 name: M line variant def: "Animals exhibit variations in the form, structure or composition of a planar structure within the muscle sarcomere which lies midway within the thick filament (A) band, attaching to the plasma membrane at its base and running up towards the inward surface of the myofilament lattice, compared to control animals (Wormatlas)." [WB:WBPerson557] is_a: WBPhenotype:0001889 ! body wall muscle sarcomere morphology variant [Term] id: WBPhenotype:0001892 name: glycogen levels variant def: "Any variation in the levels of the polymerized form of glucose throughout the body of the animal as compared to controls." [WB:WBPaper00033086, WB:WBPerson2987] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0001893 name: mitochondrial membrane potential reduced def: "Any reduction in the membrane potential (voltage gradient) across the inner mitochondrial membrane compared to control." [WB:WBPaper00033162, WB:WBPerson2987] is_a: WBPhenotype:0001282 ! mitochondrial metabolism variant [Term] id: WBPhenotype:0001894 name: nuclear number variant def: "Animals exhibit variations in the number of nuclei contained in a particular cell type compared to control." [WB:WBPaper00033438, WB:WBPerson2987] is_a: WBPhenotype:0000504 ! nuclear division variant [Term] id: WBPhenotype:0001895 name: parental chromosome mixing defective def: "Parental chromosomes fail to undergo appropriate mixing upon pronuclear fusion resulting in a zygotic nucleus in which parental genomes remain segregated." [GO:0007344, WB:WBPerson2987] synonym: "pronuclear fusion defective" RELATED [] is_a: WBPhenotype:0001138 ! nucleus defective early emb [Term] id: WBPhenotype:0001896 name: gamma ray induced apoptosis decreased def: "Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control." [WB:WBPaper00036343, WB:WBPerson2021] is_a: WBPhenotype:0000182 ! apoptosis reduced is_a: WBPhenotype:0001326 ! cell gamma ray response variant [Term] id: WBPhenotype:0001897 name: light response variant def: "Variations in the state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus (electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light) compared to control." [GO:0009416, WB:WBPaper00032087, WB:WBPerson2021] synonym: "Lite" RELATED [] is_a: WBPhenotype:0000525 ! organism behavior variant [Term] id: WBPhenotype:0001898 name: meiotic sister chromatid segregation variant def: "Variations in the process by which sister chromatids, identical chromosomes resulting from DNA replication, are physically separated during the meiotic cell cycle, compared to control." [WB:WBPaper00034684, WB:WBPerson2987] is_a: WBPhenotype:0001499 ! meiotic chromosome segregation variant [Term] id: WBPhenotype:0001899 name: glutathione levels variant def: "Animals exhibit variations in the amount of glutathione compared to control animals at a defined stage. Glutathione, the tripeptide glutamylcysteinylglycine, acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GO:0006749, WB:WBPerson557] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0001900 name: reduced levels of reduced glutathione def: "Animals exhibit a decrease in the cellular levels of reduced glutathione (GSH), compared to control. Reduced levels of GSH may be an indication of susceptibility to oxidative stress." [WB:WBPaper00034717, WB:WBPerson2987] synonym: "reduced levels of GSH" RELATED [] is_a: WBPhenotype:0001899 ! glutathione levels variant [Term] id: WBPhenotype:0001901 name: fat associated bodies variant def: "Animals exhibit variations in the formation or disassembly of fat containing organelles compared to control." [WB:WBPerson557] is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant [Term] id: WBPhenotype:0001902 name: fat associated body size increased def: "Animals exhibit an increase in the size of fat containing organelles compared to control. In C. elegans this can be assayed by BODIPY 493/503 staining." [WB:WBPaper00034742, WB:WBPerson2987] is_a: WBPhenotype:0001901 ! fat associated bodies variant [Term] id: WBPhenotype:0001903 name: centrosome biogenesis variant def: "Animals exhibit variations in the formation, maturation or disassembly of the centrosome (a subcellular body consisting of two centrioles embedded in a protein matrix). The centrosome serves as a microtubule organizing center as well as a regulator of cell-cycle progression." [WB:WBPerson557] is_a: WBPhenotype:0001344 ! organelle organization biogenesis variant [Term] id: WBPhenotype:0001904 name: manganese toxicity resistant def: "Animals fail to exhibit toxicity to the concentration of manganese that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to manganese include dopamine (DA) neuron neurodegeneration." [WB:WBPaper00035259, WB:WBPerson557] is_a: WBPhenotype:0001863 ! manganese response variant [Term] id: WBPhenotype:0001905 name: fewer eggs laid def: "Animals lay fewer total number of eggs over the lifetime of the animal." [WB:WBPaper00035252, WB:WBPerson2987] is_a: WBPhenotype:0000640 ! egg laying variant [Term] id: WBPhenotype:0001906 name: hypodermal cell elongation defective def: "During epidermal morphogenesis, hypodermal cells do not properly undergo the characteristic cell shape changes necessary for the embryo to elongate." [WB:WBPaper00003991, WB:WBPerson712] is_a: WBPhenotype:0000701 ! epithelial development variant [Term] id: WBPhenotype:0001907 name: dorsal intercalation defective def: "Animals exhibit defects in the generation of the dorsal epithelial sheet, which entails distinct cell shape changes and movements to affect the interdigitation of two rows of dorsal cells resulting in a single row of cells across the dorsal midline." [WB:WBPaper00003991, WB:WBPerson712] is_a: WBPhenotype:0000701 ! epithelial development variant [Term] id: WBPhenotype:0001908 name: ventral closure defective def: "The animal displays defects in any step of the ventral enclosure process resulting an embryo that is not enclosed and or with interior cells protruding out of the embryo." [WB:WBPaper00003991, WB:WBPerson712] is_a: WBPhenotype:0001566 ! ventral enclosure variant [Term] id: WBPhenotype:0001909 name: translational repression variant def: "Any variation in the prevention of mRNA translation that normally occurs in certain cells, compared to control." [WB:WBPerson557] is_obsolete: true [Term] id: WBPhenotype:0001910 name: kinetochore organization variant def: "Animals exhibit variations in the assembly, arrangement, orientation, or disassembly of the kinetochore, a multisubunit protein complex on chromosomes where the spindle fibers attach during cell division to pull the chromosomes apart." [GO:0051383, WB:WBPaper00035270, WB:WBPerson557] comment: Possible XP. is_a: WBPhenotype:0001348 ! chromosome morphology variant [Term] id: WBPhenotype:0001911 name: axon regeneration defective def: "Animals do not regrow axons following axon loss or damage, to the same extent, or in the same manner as observed in control animals." [WB:WBPerson712] is_a: WBPhenotype:0000880 ! axon development variant [Term] id: WBPhenotype:0001912 name: fewer coelomocytes def: "The number of coelomocytes are reduced compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds." [WB:WBPaper00035290, WB:WBPerson2987] is_a: WBPhenotype:0000618 ! coelomic system development variant [Term] id: WBPhenotype:0001913 name: excess coelomocytes def: "The number of coelomocytes are increased compared to control animals. Coelomocytes are free-floating spherical cells lying in the pseudocoelomic cavity of animals that can endocytose many compounds." [WB:WBPaper00035290, WB:WBPerson2987] is_a: WBPhenotype:0000618 ! coelomic system development variant [Term] id: WBPhenotype:0001914 name: fewer pharyngeal cells def: "Animals contain fewer pharyngeal cells compared to control animals. In C. elegans, pharyngeal cells are derived from MS-blastomere." [WB:WBPaper00035290, WB:WBPerson2987] is_a: WBPhenotype:0000707 ! pharyngeal development variant [Term] id: WBPhenotype:0001915 name: mRNA expression ectopic def: "Any variation that results in the cellular expression of an mRNA in cells/tissues, that is otherwise not observed in control animals." [WB:WBPaper00035290, WB:WBPerson2987] is_a: WBPhenotype:0000114 ! mRNA expression variant [Term] id: WBPhenotype:0001916 name: increased pathogen survival def: "Pathogens internally associated with the animal exhibit an increase in survival compared to control animals." [WB:WBPaper00035289, WB:WBPerson2987] is_a: WBPhenotype:0001819 ! pathogen load variant [Term] id: WBPhenotype:0001917 name: protein acetylation variant def: "Variations in the processes that incorporate acetyl groups to one or more amino acids within a protein, compared to control. An acetyl group is CH3CO-." [GO:0006473, WB:WBPaper00025192, WB:WBPerson557] is_a: WBPhenotype:0001382 ! protein modification variant [Term] id: WBPhenotype:0001918 name: chemical hypersensitive def: "Animals respond to a specific chemical at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000523 ! chemical response variant [Term] id: WBPhenotype:0001919 name: gut granules enlarged def: "Animals exhibit larger inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPaper00035924, WB:WBPerson2987] is_a: WBPhenotype:0000902 ! intestinal cell morphology variant [Term] id: WBPhenotype:0001920 name: twisted pharynx def: "The growth of pharyngeal components occurs in a radial fashion around the longitudinal axis of the worm as demonstrated by bent radial contractile arrays within the pharyngeal muscle cells. The defect is more pronounced as development progresses resulting in a more obvious twisting phenotype. Depending on the allele, the twist can be right-handed or left-handed" [WB:WBPaper00030736, WB:WBPerson712] synonym: "pharynx twisted" RELATED [] synonym: "Twp" RELATED [] is_a: WBPhenotype:0000707 ! pharyngeal development variant [Term] id: WBPhenotype:0001921 name: meiotic DNA double strand break formation variant def: "Any variation in the creation of double-strand breaks that occur during meiosis that may result in the initiation of meiotic recombination." [GO:0042138, WB:WBPerson557] comment: Possible XP. is_a: WBPhenotype:0000775 ! meiosis variant [Term] id: WBPhenotype:0001922 name: axonal transport variant def: "Any variation in the directed movement of organelles or molecules along microtubules in nerve cell axons." [GO:0008088, WB:WBPerson557] comment: Possible XP. synonym: "axon cargo transport variant" RELATED [] is_a: WBPhenotype:0000991 ! neuron physiology variant [Term] id: WBPhenotype:0001923 name: fewer seam cells def: "The population of the lateral, alae-producing epithelial cells (seam cells) is reduced compared to control animals." [WB:WBPaper00034768] is_a: WBPhenotype:0000701 ! epithelial development variant [Term] id: WBPhenotype:0001924 name: oocytes stacked def: "Oocytes are found one on top of the other in the dorsal to ventral orientation in the gonad." [WB:WBPerson557] is_a: WBPhenotype:0001260 ! oocyte morphology variant [Term] id: WBPhenotype:0001925 name: oocytes disorganized def: "Oocytes are no longer arranged in the gonad in the same manner as control animals." [WB:WBPerson557] is_a: WBPhenotype:0001260 ! oocyte morphology variant [Term] id: WBPhenotype:0001926 name: gonad sheath contraction rate increased def: "Basal contraction rate and or peak contraction rate of the gonadal sheath is increased relative to control animals." [WB:WBPaper00027739, WB:WBPerson2987] is_a: WBPhenotype:0001199 ! gonad sheath contractions variant [Term] id: WBPhenotype:0001927 name: extra distal tip cells def: "Animals produce an excess number of distal tip cells compared to controls." [WB:WBPaper00033102, WB:WBPerson2987] is_a: WBPhenotype:0001656 ! distal tip cell development variant [Term] id: WBPhenotype:0001928 name: extra gonad arms def: "Animals produce an excess number of gonad arms compared to controls." [WB:WBPaper00033102, WB:WBPerson2987] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0001929 name: linker cell absent def: "The gonads of male animals do not produce the linker cell involved in guiding the developing male gonad to the sex organs in the male tail." [WB:WBPaper00033102, WB:WBPerson2987] is_a: WBPhenotype:0001675 ! male gonad development variant [Term] id: WBPhenotype:0001930 name: muscle arm development defective def: "Animals extend altered or fewer numbers of dorsal and or ventral muscle arms compared to control animals. " [WB:WBPaper00032907, WB:WBPerson712] synonym: "Madd" RELATED [] synonym: "muscle arm extension defective" RELATED [] is_a: WBPhenotype:0000540 ! muscle arm development variant [Term] id: WBPhenotype:0001931 name: muscle arm axon connection variant def: "The morphology or number of connections between muscle arms and commissural motor axons varies from control animals. " [WB:WBPaper00032907, WB:WBPerson712] is_a: WBPhenotype:0000540 ! muscle arm development variant [Term] id: WBPhenotype:0001932 name: myopodia present def: "Animals exhibit ectopic plasma membrane extensions from muscle, these extensions are random projections that are thinner than the typical muscle arm." [WB:WBPaper00032907, WB:WBPerson712] is_a: WBPhenotype:0000904 ! muscle cell morphology variant [Term] id: WBPhenotype:0001933 name: synaptic vesicle tag abnormal in mechanosensory neurons def: "The pattern of localization of presynaptic markers is disrupted compared to control animals. " [WB:WBPaper00035070, WB:WBPerson712] synonym: "Sam" RELATED [] is_a: WBPhenotype:0000847 ! presynaptic component localization variant [Term] id: WBPhenotype:0001934 name: vulval muscle extension variant def: "Any variation in the extension of vulval muscles compared to control. In C. elegans contralateral vulval muscles fail to meet at the midline." [WB:WBPaper00036485, WB:WBPerson712] synonym: "Vme" RELATED [] is_a: WBPhenotype:0001314 ! vulval muscle variant [Term] id: WBPhenotype:0001935 name: protein aggregation induced paralysis def: "Animals become paralyzed in response to aggregation of proteins like poly-glutamine or beta-amyloid." [WB:WBPaper00033115, WB:WBPerson2987] is_a: WBPhenotype:0001405 ! protein aggregation variant [Term] id: WBPhenotype:0001936 name: resistant to protein aggregation induced paralysis def: "Animals fail to respond to the aggregation of proteins that elicits a paralysis response in control animals." [WB:WBPaper00033115, WB:WBPerson2987] is_a: WBPhenotype:0001935 ! protein aggregation induced paralysis [Term] id: WBPhenotype:0001937 name: hypersensitive to protein aggregation induced paralysis def: "Animals respond to protein aggregation at a lower concentration of aggregates or in less time compared to control animals." [WB:WBPaper00033115, WB:WBPerson2987] is_a: WBPhenotype:0001935 ! protein aggregation induced paralysis [Term] id: WBPhenotype:0001938 name: DNA repair variant def: "Any variation in the process of restoring DNA after damage. DNA damage can be caused by a many chemical or physical agents, and this damage is repaired by a variety of different DNA repair pathways." [GO:0006281, WB:WBPerson557] is_a: WBPhenotype:0000732 ! DNA metabolism variant [Term] id: WBPhenotype:0001939 name: bitter tastant response variant def: "Animals are not repelled by bitter tastants such as quinine, primaquine quinacrine etc., to the same extent as control animals. " [WB:WBPaper00035961, WB:WBPerson712] is_a: WBPhenotype:0001450 ! aqueous negative chemotaxis variant [Term] id: WBPhenotype:0001940 name: rachis morphology variant def: "Any variation in the form, structure or composition of the nucleus-free core of germ line cytoplasm in the gonad compared to control animals. In the C. elegans germline, nuclei exiting mitosis and entering meiosis are arranged along the cortex of the germline, partially enclosed by cellular membrane, forming a nucleus-free core of germline cytoplasm, called the rachis." [WB:WBPaper00031889, WB:WBPerson557] synonym: "rachis morphology abnormal" RELATED [] is_a: WBPhenotype:0001355 ! gonad morphology variant [Term] id: WBPhenotype:0001941 name: rachis narrow def: "The nucleus-free core of germline cytoplasm in the gonad is not as wide as control animals." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001940 ! rachis morphology variant [Term] id: WBPhenotype:0001942 name: rachis absent def: "The nucleus-free core of germline cytoplasm in the gonad is missing." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001940 ! rachis morphology variant [Term] id: WBPhenotype:0001943 name: rachis wide def: "The width of the nucleus-free core of germline cytoplasm in the gonad is larger compared to control animals." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001940 ! rachis morphology variant [Term] id: WBPhenotype:0001944 name: oocyte number decreased def: "A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control." [WB:WBPaper00038381, WB:WBPerson557] synonym: "fewer oocytes" RELATED [] is_a: WBPhenotype:0000186 ! oogenesis variant is_a: WBPhenotype:0001260 ! oocyte morphology variant [Term] id: WBPhenotype:0001945 name: oocytes small def: "The size of haploid female germ cells (oocytes) are significantly smaller compared to control." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001260 ! oocyte morphology variant [Term] id: WBPhenotype:0001946 name: pachytene progression during oogenesis variant def: "Developing oocytes show defects in their entry, progression through or exit from the pachytene stage compared to control animals. Pachytene is a cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GO:0000239, WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001824 ! meiotic progression prophase variant [Term] id: WBPhenotype:0001947 name: diplotene progression during oogenesis variant def: "Developing oocytes show defects in their entry, progression through or exit from the diplotene stage compared to control animals. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001824 ! meiotic progression prophase variant [Term] id: WBPhenotype:0001948 name: diakinesis progression during oogenesis variant def: "Developing oocytes show defects in their entry, progression through or exit from the diakinesis stage compared to control animals. Diakinesis is a cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GO:0000241, WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001824 ! meiotic progression prophase variant [Term] id: WBPhenotype:0001949 name: diakinesis region organization variant def: "Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diakinesis stage. In C. elegans the diakinesis region occurs in the proximal gonad arm and is preceded by the diplotene region. In the diakinesis region oocytes arrest until oocyte maturation occurs." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001355 ! gonad morphology variant is_a: WBPhenotype:0001948 ! diakinesis progression during oogenesis variant [Term] id: WBPhenotype:0001950 name: diplotene region organization variant def: "Animals exhibit variations from control animals in the organization of the germ cell nuclei in the gonad that are in the diplotene stage. In C. elegans the diplotene region follows the pachytene region and occurs just distal to, and coincident with, the loop in the gonad arm. In the diplotene region germ cell compartments become organized into a single file." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001355 ! gonad morphology variant is_a: WBPhenotype:0001947 ! diplotene progression during oogenesis variant [Term] id: WBPhenotype:0001951 name: pachytene region organization variant def: "Animals exhibit variations from control animals in the organization of the germ cell nuclei in the pachytene stage region of the gonad. In C. elegans the pachytene region begins just proximal to the germline's transition zone, where germ cells coordinately switch into the leptotene/zygotene stage from the premeiosis stage (WormAtlas)." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001355 ! gonad morphology variant is_a: WBPhenotype:0001946 ! pachytene progression during oogenesis variant [Term] id: WBPhenotype:0001952 name: germline nuclear positioning variant def: "Variations in the directed movement/or positioning of a nucleus to a specific location within the germline compartment compared to control." [WB:WBPaper00038381, WB:WBPerson557] synonym: "germline nuclear migration variant" RELATED [] is_a: WBPhenotype:0000511 ! nuclear positioning variant [Term] id: WBPhenotype:0001953 name: nuclear fallout def: "Nuclei have fallen out of developing germ cell compartments into the rachis." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001952 ! germline nuclear positioning variant [Term] id: WBPhenotype:0001954 name: diplotene absent during oogenesis def: "The diplotene stage is not observed in developing oocytes. Diplotene is a cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GO:0000240, WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001947 ! diplotene progression during oogenesis variant [Term] id: WBPhenotype:0001955 name: multiple nuclei oocyte def: "Haploid female germ cells (oocytes) contain more than one nucleus." [WB:WBPaper00038381, WB:WBPerson557] synonym: "multinucleate oocyte" RELATED [] is_a: WBPhenotype:0000186 ! oogenesis variant is_a: WBPhenotype:0001260 ! oocyte morphology variant is_a: WBPhenotype:0001894 ! nuclear number variant [Term] id: WBPhenotype:0001956 name: oocytes lack nucleus def: "Haploid female germ cells (oocytes) lack a nucleus." [WB:WBPaper00038381, WB:WBPerson557] synonym: "anucleate oocytes" RELATED [] is_a: WBPhenotype:0000186 ! oogenesis variant is_a: WBPhenotype:0001260 ! oocyte morphology variant [Term] id: WBPhenotype:0001957 name: gonad small def: "A decrease in size of the specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001355 ! gonad morphology variant [Term] id: WBPhenotype:0001958 name: gonad degenerate def: "Animals contain a gonad that initially functioned, but subsequently stopped. In hermaphrodites or females there is often the presence old embryos and/or hatched larva, but no young embryos, in the uterus." [WB:WBPaper00038381, WB:WBPerson557] synonym: "degenerate gonad" RELATED [] is_a: WBPhenotype:0001355 ! gonad morphology variant [Term] id: WBPhenotype:0001959 name: spindle pole pulling force variant def: "Pulling forces on the astral microtubules at the spindle poles vary from that observed for control spindles. " [WB:WBPaper00031928, WB:WBPerson712] is_a: WBPhenotype:0000759 ! spindle defective early emb [Term] id: WBPhenotype:0001960 name: spindle oscillation variant def: "The spindle in the early embryo is aberrant in the characteristic posterior aster oscillations that occur along the transverse longitudinal axis of the spindle. " [WB:WBPaper00031928, WB:WBPerson712] is_a: WBPhenotype:0000759 ! spindle defective early emb [Term] id: WBPhenotype:0001961 name: reproductive longevity extended def: "Animals continue to produce progeny significantly past the time reproduction stops in control animals." [WB:WBPaper00031688, WB:WBPerson712] is_a: WBPhenotype:0001739 ! aging variant [Term] id: WBPhenotype:0001962 name: missing distal tip cells def: "Animals produce less distal tip cells compared to controls." [WB:WBPaper00026603, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0001656 ! distal tip cell development variant [Term] id: WBPhenotype:0001963 name: homolog association variant def: "The association of homologs during diakinesis and the maintenance of their association through meiosis I as well as the preservation of centromeric cohesin between sister chromatids does not proceed as it does in control animals." [WB:WBPaper00032269, WB:WBPerson712] is_a: WBPhenotype:0001824 ! meiotic progression prophase variant [Term] id: WBPhenotype:0001964 name: dopaminergic fate atypical def: "Animals exhibit differential regulation of the dopaminergic fate among the various classes of dopaminergic neurons." [WB:WBPaper00032147, WB:WBPaper00036201, WB:WBPerson712] synonym: "Dopy" RELATED [] is_a: WBPhenotype:0001510 ! neuronal cell fate specification variant [Term] id: WBPhenotype:0001965 name: cell membrane physiology variant def: "Animals exhibit variations in any physical or chemical process required for the composition, component distribution, or other aspect of membranes of the cell, compared to control animals." [WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0001966 name: cell endomembrane physiology variant def: "Animals exhibit variations in any physical or chemical process required for the composition, component distribution, or other aspect of membranes of within the cell, compared to control animals." [WB:WBPaper00037899, WB:WBPerson712] is_a: WBPhenotype:0001965 ! cell membrane physiology variant [Term] id: WBPhenotype:0001967 name: meiotic chromatin reorganization variant def: "Animals differ from control animals in the length of or mechanics of the steps that culminate in the preservation and subsequent disassembly of the synaptonemal complex, the specification of bivalent arms, and proper cohesion of sister chromatids." [WB:WBPaper00032269, WB:WBPerson712] is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0001968 name: somatic gonad precursor symmetrical sisters def: "All somatic gonad precursor (SGP) daughters adopt a proximal fate resulting in an increase in the number of AC precursor cells at the expense of distal tip cells (DTC), which are thereby absent." [WB:WBPaper00026603, WB:WBPerson712] synonym: "symmetrical sisters " RELATED [] synonym: "Sys" BROAD [] is_a: WBPhenotype:0000399 ! somatic gonad development variant is_a: WBPhenotype:0001235 ! cell division polarity variant [Term] id: WBPhenotype:0001969 name: germ cell compartment morphology variant def: "Any variation in the form or composition of the compartments in the germline of females/hermaphrodites compared to control animals. In C. elegans these compartments contain a nucleus and are connected to a common cytoplasm (rachis). These compartments eventually undergo cellularization and become oocytes." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0000900 ! germ cell morphology variant [Term] id: WBPhenotype:0001970 name: germ cell compartment nuclei number variant def: "Germ cell compartments contain an an atypical number on nuclei compared to control." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001969 ! germ cell compartment morphology variant [Term] id: WBPhenotype:0001971 name: germ cell compartment anucleate def: "Germ cell compartments do not contain a nucleus." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001970 ! germ cell compartment nuclei number variant [Term] id: WBPhenotype:0001972 name: germ cell compartment multinucleate def: "Germ cell compartments contain multiple nuclei." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001970 ! germ cell compartment nuclei number variant [Term] id: WBPhenotype:0001973 name: germ cell compartment size variant def: "Any variation in germ cell compartment size compared to control." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001969 ! germ cell compartment morphology variant [Term] id: WBPhenotype:0001974 name: germ cell compartment small def: "Germ cell compartments are smaller than that of control animals." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001973 ! germ cell compartment size variant [Term] id: WBPhenotype:0001975 name: germ cell compartment large def: "Germ cell compartments are larger than that of control animals." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001973 ! germ cell compartment size variant [Term] id: WBPhenotype:0001977 name: germ cell partition morphology variant def: "Any variation in the form or composition of the compartment partitions in the germline of females/hermaphrodites that exist when nuclei are still connected to a common cytoplasm (rachis), compared to control animals. " [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001969 ! germ cell compartment morphology variant [Term] id: WBPhenotype:0001978 name: germ cell partition absent alt_id: WBPhenotype:0001976 def: "Animals lack germ cell partitions (germ cell compartments)." [WB:WBPaper00038381, WB:WBPerson557] synonym: "germ cell compartment absent" EXACT [] is_a: WBPhenotype:0001977 ! germ cell partition morphology variant [Term] id: WBPhenotype:0001979 name: gonad vesiculated def: "Animals contain small, fluid-filled, anucleate, spherical membrane-bound structures within the gonad." [GO:0031982, WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001355 ! gonad morphology variant [Term] id: WBPhenotype:0001980 name: germ cell compartment expansion variant def: "Animals exhibit variations in the increase in size of compartments of the germline. In the C. elegans germline, syncytial compartments enlarge just prior to and coincident with the loop region, eventually abscising, to become fully enclosed germ cells (oocytes)." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001969 ! germ cell compartment morphology variant [Term] id: WBPhenotype:0001981 name: germ cell compartment expansion absent def: "The compartments of the germline do not increase in size." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0001980 ! germ cell compartment expansion variant [Term] id: WBPhenotype:0001982 name: cell membrane organization biogenesis variant def: "Variations in the process(es) involved in the assembly, transport, arrangement or disassembly of cell membrane structures or components compared to control." [WB:WBPaper00038381, WB:WBPerson557] is_a: WBPhenotype:0010002 ! cell organization biogenesis variant [Term] id: WBPhenotype:0001983 name: lawn leaving behavior variant def: "Variation of the time an individual spent on a patch of food (bacterial lawn) before leaving, compared to control animals. " [WB:WBPaper00038234, WB:WBPerson363] synonym: "" NARROW [] synonym: "exploration behavior variant" RELATED [] synonym: "exploratory behavior variant" NARROW [] synonym: "patch leaving behavior variant" EXACT [] is_a: WBPhenotype:0000662 ! foraging behavior variant [Term] id: WBPhenotype:0001984 name: long range axon migration variant def: "Animals exhibit axons with migration behaviors that differ from those observed in control animals after the axons cross a half-way point between opposing neural cords. In C. elegans this point is marked by the lateral seam cells between the ventral and dorsal cords." [WB:WBPaper00038105, WB:WBPerson712] is_a: WBPhenotype:0001224 ! axon outgrowth variant [Term] id: WBPhenotype:0001985 name: short range axon migration variant def: "Animals exhibit axons with migration behaviors that differ from those observed in control animals before the axons reach a half-way point between opposing neural cords. In C. elegans this point is marked by the lateral seam cells between the ventral and dorsal cords." [WB:WBPaper00038105, WB:WBPerson712] is_a: WBPhenotype:0001224 ! axon outgrowth variant [Term] id: WBPhenotype:0001986 name: high temperature induced L1 arrest def: "Animals undergo an irreversible high temperature-induced developmental arrest during the first larval stage." [WB:WBPaper00038168, WB:WBPerson2987] is_a: WBPhenotype:0000081 ! L1 arrest is_a: WBPhenotype:0001273 ! organism heat response variant [Term] id: WBPhenotype:0001987 name: acetylcholinesterase activity variant def: "Any variation in the measured levels of acetylcholinesterase (AChE) activity compared to control animals. " [WB:WBPaper00001039, WB:WBPerson712] synonym: "acetylcholinesterase class activity variant" EXACT [] is_a: WBPhenotype:0000124 ! enzyme activity reduced [Term] id: WBPhenotype:0001988 name: detergent hypersensitive def: "Animals respond to a detergent at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00000514, WB:WBPerson712] is_a: WBPhenotype:0001918 ! chemical hypersensitive [Term] id: WBPhenotype:0001989 name: hypoxia hypersensitive def: "Animals respond to hypoxic (low oxygen levels) stress after a shorter exposure time compared to control." [WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000464 ! oxygen response variant [Term] id: WBPhenotype:0001990 name: hypoxia resistant def: "Animals fail to respond to low amounts of oxygen that elicit a response in control animals." [WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000464 ! oxygen response variant [Term] id: WBPhenotype:0001991 name: hypoxia response attenuated def: "Response to low levels of oxygen is reduced or weakened compared to the response of control animals." [WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000464 ! oxygen response variant [Term] id: WBPhenotype:0001992 name: extra gonadal sheath cells def: "Animals exhibit an increase in the number of somatic sheath cells surrounding each gonad arm compared to controls." [WB:WBPaper00006209, WB:WBPerson2987] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0001993 name: fewer gonadal sheath cells def: "Animals exhibit fewer somatic sheath cells surrounding each gonad arm, compared to controls." [WB:WBPaper00006209, WB:WBPerson2987] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0001994 name: left right handedness variant def: "Any variation in the establishment of left-right asymmetry of the body axis compared to controls." [WB:WBPerson2987, WB:WBPerson557] synonym: "left right asymmetry variant" RELATED [] is_a: WBPhenotype:0000578 ! body axis development variant [Term] id: WBPhenotype:0001995 name: cell cycle progression variant def: "Cells of the animals exhibit variations in the progression or exit from the biochemical and morphological processes that occur during successive replication or nuclear replication events from that observed for control animals." [GO:0007049, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000740 ! cell cycle variant [Term] id: WBPhenotype:0001996 name: cell cycle quiescence variant def: "Any variation in the cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence before entering the S phase, compared to control." [GO:0070314, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0001995 ! cell cycle progression variant [Term] id: WBPhenotype:0001997 name: nuclear anchoring variant def: "The nucleus or nuclei are not positioned in a similar manner or pattern in the cell or syncytium to that observed in controls. " [WB:WBPaper00003628, WB:WBPerson712] is_a: WBPhenotype:0000511 ! nuclear positioning variant [Term] id: WBPhenotype:0001998 name: hypersensitive to laser ablation def: "Animals respond more severely to laser ablation than control animals subjected to the same laser ablation conditions." [WB:WBPaper00038282, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0001999 name: conflicting sensory integration variant def: "Animals behave differently from control animals in assays testing for the ability to resolve or respond to conflicting sensory inputs." [WB:WBPaper00038243, WB:WBPerson712] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0002000 name: recovery from enhanced locomotion variant def: "Animals that exhibit an increase in locomotion activity do not return to basal level locomotion activity at the same rate as that of control animals." [WB:WBPaper00038487, WB:WBPerson712] is_a: WBPhenotype:0000641 ! activity level variant [Term] id: WBPhenotype:0002001 name: synapse density variant def: "The number of synapses per unit area of a neuron differs in the animal compared to that observed for control animals." [WB:WBPaper00039786, WB:WBPerson712] is_a: WBPhenotype:0000604 ! nervous system morphology variant [Term] id: WBPhenotype:0002002 name: supernumerary centrosomes def: "A cell or cell of the animal exhibits extra centrosomes (a subcellular body consisting of two centrioles embedded in a protein matrix) compared to control." [WB:WBPaper00028464, WB:WBPerson2987] is_a: WBPhenotype:0001903 ! centrosome biogenesis variant [Term] id: WBPhenotype:0002003 name: hydrogen peroxide homeostasis variant def: "Animals exhibit variations in steady-state levels of hydrogen peroxide (H2O2) compared to control." [WB:WBPaper00040082, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0002004 name: actomyosin contractillity defective def: "Animals exhibit defects in the flow rate or targeting of the cortical actomyosin network, which occurs during polarization as well as contraction of the contractile ring, compared to control animals." [WB:WBPaper00038098, WB:WBPerson712] is_a: WBPhenotype:0000034 ! embryonic polarity variant is_a: WBPhenotype:0001018 ! cytokinesis variant emb is_a: WBPhenotype:0001587 ! actin organization biogenesis variant [Term] id: WBPhenotype:0002005 name: actomyosin cytoskeletal tension variant def: "The tension of the cytoskeleton comprised of the actomyosin network differs from controls. This tension can be measured by laser-cutting of the actomyosin cytoskeleton and observing any differences the recoil velocity of cortex adjacent to the cut site." [WB:WBPaper00038098, WB:WBPerson712] is_a: WBPhenotype:0001346 ! actin cytoskeleton dynamics variant [Term] id: WBPhenotype:0002006 name: anaphase I progression variant early embryo def: "Compared to controls, embryos exhibit variations in the part meiosis I in which homologous chromosomes separate and migrate away from each other." [WB:WBPaper00031064, WB:WBPerson712] is_a: WBPhenotype:0000775 ! meiosis variant [Term] id: WBPhenotype:0002007 name: cortical blebs present def: "Embryos display cortical protusions during cytokinesis." [WB:WBPaper00038098, WB:WBPerson712] is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant is_a: WBPhenotype:0001078 ! cytokinesis defective early emb [Term] id: WBPhenotype:0002008 name: glycation variant def: "Animals exhibit variations in the non-enzymatic glycosylation process of attaching a protein or lipid to a sugar molecule, compared to control animals. " [WB:WBPaper00040082, WB:WBPerson712] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0002009 name: proteasome core activity variant def: "Animals exhibit variations from controls in their protein degradation machinery, which functions through the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [GO:0004175, WB:WBPaper00040082, WB:WBPerson712] is_a: WBPhenotype:0001644 ! protein metabolism variant [Term] id: WBPhenotype:0002010 name: protein turnover variant def: "The dynamics of the replacement of old proteins by newly synthesized or modified proteins varies from that of control animals. This phenotype is often measured by fluorescence recovery after photobleaching (FRAP)." [WB:WBPaper00038098, WB:WBPerson712] is_a: WBPhenotype:0001644 ! protein metabolism variant [Term] id: WBPhenotype:0002011 name: bivulva def: "Animals exhibit a secondary vulval invagination that is anterior or posterior to the primary opening depending on the the inappropriate placement of daughter cells along the anterior/posterior axis during vulval development." [WB:WBPaper00040151, WB:WBPerson712] is_a: WBPhenotype:0000695 ! vulva morphology variant [Term] id: WBPhenotype:0002012 name: meiotic chromosome organization variant def: "Any variation in the process of chromosome organization that is involved in meiosis, compared to control." [GO:0070192, WB:WBPerson557] is_a: WBPhenotype:0000775 ! meiosis variant [Term] id: WBPhenotype:0002013 name: univalent meiotic chromosomes def: "Chromosomes fails to pair with homologous chromosomes during the prophase stage of meiosis." [WB:WBPerson101, WB:WBPerson557] is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0002014 name: current measurement variant def: "Any observed variation in the measurement of current across the cell membrane compared to measurements in control animals. Current is a flow of electric charge through a medium." [WB:WBPerson557] is_a: WBPhenotype:0001315 ! electrophysiology variant [Term] id: WBPhenotype:0002015 name: voltage measurement variant def: "Any observed variation in the measurement of voltage across the cell membrane compared to measurements in control animals. Voltage is the difference in electric potential energy per unit charge between two points." [WB:WBPerson557] is_a: WBPhenotype:0001315 ! electrophysiology variant [Term] id: WBPhenotype:0002016 name: biotin chemotaxis defective def: "Failure to execute the characteristic response to biotin as defined by control animals. In C. elegans, biotin is typically an attractant." [WB:WBPaper00001481, WB:WBPaper00005801, WB:WBPerson101, WB:WBPerson557] is_a: WBPhenotype:0001441 ! aqueous positive chemotaxis defective [Term] id: WBPhenotype:0002017 name: VPC competence variant def: "Any variation in the ability of multipotent vulval precursor cells to respond to signals compared to control animals." [WB:WBPerson557] synonym: "vulval precursor cell competence abnormal" RELATED [] synonym: "vulval precursor cell competence variant" RELATED [] is_a: WBPhenotype:0000216 ! cell fate specification variant [Term] id: WBPhenotype:0002018 name: retarded seam cell fusion def: "Seam cells fuse to form a continuous syncytium along the bodywall at a later stage of development compared to control." [WB:WBPaper00031488, WB:WBPerson2987] is_a: WBPhenotype:0000166 ! seam cell fusion variant [Term] id: WBPhenotype:0002019 name: fewer eggs in utero def: "Adult animals display a smaller number of eggs inside the uterus compared to controls " [WB:WBPaper00031804, WB:WBPerson2987] is_a: WBPhenotype:0000624 ! reproductive system development variant [Term] id: WBPhenotype:0002020 name: transmission of nerve impulse variant def: "Transmission of the signal along the neuron varies from control. This process includes the flow of information from the neuron cell body to the synapse and across to the postsynaptic cell." [GO:0019226, WB:WBPaper00031592, WB:WBPerson712] is_a: WBPhenotype:0000612 ! nervous system physiology variant [Term] id: WBPhenotype:0002021 name: synaptic spike frequency variant def: "Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed at the synapse, which are independent of presynaptic inputs." [WB:WBPaper00031592, WB:WBPerson712] is_a: WBPhenotype:0000584 ! synaptic transmission variant is_a: WBPhenotype:0002023 ! spike frequency variant [Term] id: WBPhenotype:0002022 name: no synaptic spike frequency def: "Calcium transients at presynaptic regions do not occur." [WB:WBPaper00031592, WB:WBPerson712] is_a: WBPhenotype:0002021 ! synaptic spike frequency variant [Term] id: WBPhenotype:0002023 name: spike frequency variant def: "Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed either at the cell body or the synaptic region, which are independent of presynaptic inputs." [WB:WBPaper00031592, WB:WBPerson712] is_a: WBPhenotype:0002020 ! transmission of nerve impulse variant [Term] id: WBPhenotype:0002024 name: cell body spike frequency variant def: "Animals exhibit variations in the autonomously initiated periodic trains of calcium transients observed in cell bodies, which are independent of presynaptic inputs." [WB:WBPaper00031592, WB:WBPerson712] is_a: WBPhenotype:0002023 ! spike frequency variant [Term] id: WBPhenotype:0002025 name: cell size decreased def: "The diameter, volume, or area taken up by a cell differs from that measured in control animals. " [WB:WBPaper00038069, WB:WBPerson712] is_a: WBPhenotype:0000533 ! cell morphology variant [Term] id: WBPhenotype:0002026 name: differential touch sensitivity variant def: "Animals differ from control animals in response to mechanical stimulation targeting different parts of the same cell. In N2 wild-type animals, response to touch near the ALM cell body is reduced compared with touch of the cell area near the second pharyngeal bulb." [WB:WBPaper00040149, WB:WBPerson712] is_a: WBPhenotype:0000315 ! mechanosensation variant [Term] id: WBPhenotype:0002027 name: gonad independent vulva differentiation def: "VPCs differentiate in the absence of inductive signals coming from the gonad. " [WB:WBPaper00025001, WB:WBPaper00027764, WB:WBPerson712] synonym: "Gid" EXACT [] is_a: WBPhenotype:0000354 ! cell differentiation variant is_a: WBPhenotype:0001272 ! vulval cell induction variant [Term] id: WBPhenotype:0002028 name: mechanoreceptor current variant def: "Animals differ from controls in their electrical response to mechanical stimulus." [WB:WBPaper00040149, WB:WBPerson712] synonym: "MRC variant" RELATED [] is_a: WBPhenotype:0000315 ! mechanosensation variant [Term] id: WBPhenotype:0002029 name: metal homeostasis variant def: "Variations in the regulation of levels, transport, and metabolism of metal ions within an organism compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0002030 name: magnesium homeostasis variant def: "Variations in the regulation of levels, transport, and metabolism of magnesium ions within an organism compared to control." [GO:0010960, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0002029 ! metal homeostasis variant [Term] id: WBPhenotype:0002031 name: lectin response variant def: "Exposure to carbohydrate binding gene products result in an altered action in comparison to controls." [WB:WBPaper00038311, WB:WBPerson712] is_a: WBPhenotype:0000459 ! pesticide response variant is_a: WBPhenotype:0001210 ! pericellular component physiology variant [Term] id: WBPhenotype:0002032 name: lectin binding variant def: "Animals differ from controls in the range, specificity, or presence of targets for exogenously applied lectins." [WB:WBPaper00038311, WB:WBPerson712] is_a: WBPhenotype:0002031 ! lectin response variant [Term] id: WBPhenotype:0002033 name: lectin binding occurs def: "Animals contain targets for exogenously\napplied lectins." [WB:WBPaper00038311, WB:WBPerson712] synonym: "ectopic lectin binding" RELATED [] is_a: WBPhenotype:0002031 ! lectin response variant [Term] id: WBPhenotype:0002034 name: lectin binding does not occur def: "Animals are not observed to contain targets for exogenously applied lectins." [WB:WBPaper00038311, WB:WBPerson712] is_a: WBPhenotype:0002031 ! lectin response variant [Term] id: WBPhenotype:0002035 name: resistant to lectin def: "Exposure to lectin has no affect on the behavior, growth, or development of the animal compared to controls." [WB:WBPaper00038311, WB:WBPerson712] is_a: WBPhenotype:0002031 ! lectin response variant [Term] id: WBPhenotype:0002036 name: susceptible to lectin def: "Exposure to lectin results in altered behavior, growth, or development of the animal compared to controls." [WB:WBPaper00038311, WB:WBPerson712] is_a: WBPhenotype:0002031 ! lectin response variant [Term] id: WBPhenotype:0002037 name: nuclear envelope organization variant def: "The appearance and association of components along the double lipid bilayer enclosing the nucleus differs from controls. The NE separates nuclear contents from the rest of the cytoplasm and includes the intermembrane space, perinuclear space." [WB:WBPaper00040620, WB:WBPerson712] is_a: WBPhenotype:0001028 ! nuclear appearance variant [Term] id: WBPhenotype:0002038 name: ciliary localization defective def: "Proteins show defects in their localization in the cilia compared to control animals." [WB:WBPaper00031689] synonym: "cil" BROAD [] is_a: WBPhenotype:0000851 ! ciliated neuron physiology variant [Term] id: WBPhenotype:0002039 name: retrograde transport variant def: "Animals exhibit variation in the directed movement of organelles or molecules along microtubules from the cell periphery in nerve cell axons to the cell body, compared to control." [WB:WBPaper00038442, WB:WBPerson712] is_a: WBPhenotype:0000853 ! intraflagellar transport variant [Term] id: WBPhenotype:0002040 name: asymmetric chromosome segregation def: "Chromosomes are not segregated symmetrically during mitosis." [WB:WBPaper00038412, WB:WBPerson712] synonym: "chaotic mitosis" RELATED [] is_a: WBPhenotype:0001378 ! mitotic chromosome segregation variant [Term] id: WBPhenotype:0002041 name: molt variant def: "Animals exhibit variation in timing or ability to molt." [WB:WBPaper00040467, WB:WBPerson712] is_a: WBPhenotype:0000750 ! larval development variant [Term] id: WBPhenotype:0002042 name: molting arrhythmic def: "Molting cycles do not occur in a temporally controlled manner and cannot be synchronized across a population. " [WB:WBPaper00040467, WB:WBPerson712] is_a: WBPhenotype:0002041 ! molt variant [Term] id: WBPhenotype:0002043 name: hermaphrodite mating efficiency reduced def: "The number of cross progeny produced by hermaphrodites is reduced compared to control hermaphrodites." [WB:WBPerson557] is_a: WBPhenotype:0004001 ! hermaphrodite mating variant [Term] id: WBPhenotype:0002044 name: hermaphrodite mating efficiency eliminated def: "Hermaphrodites do not produce cross progeny." [WB:WBPerson557] is_a: WBPhenotype:0002043 ! hermaphrodite mating efficiency reduced [Term] id: WBPhenotype:0002045 name: cell corpse number decreased def: "Animals exhibit fewer cell corpses compared to controls at the same developmental life stage." [WB:WBPerson712] is_a: WBPhenotype:0000590 ! cell corpse number variant [Term] id: WBPhenotype:0002046 name: iron homeostasis variant def: "Variations in the regulation of levels, transport, and metabolism of iron within an organism compared to control." [GO:0055072, WB:WBPerson557] is_a: WBPhenotype:0002029 ! metal homeostasis variant [Term] id: WBPhenotype:0002047 name: muscimol response variant def: "Animals exhibit variations in their response to muscimol compared to that observed in control animals. Muscimol is a GABA-A receptor agonist." [WB:WBPaper00038249, WB:WBPerson712] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0002048 name: abamectin resistant def: "Animals survive longer, or do not respond to the same degree as control animals under similar conditions of abamectin exposure." [WB:WBPaper00040740, WB:WBPerson712] is_a: WBPhenotype:0002049 ! abamectin repsonse variant [Term] id: WBPhenotype:0002049 name: abamectin repsonse variant def: "Animals are not affected to the same degree as control animals under similar conditions of abamectin exposure. " [WB:WBPaper00040740, WB:WBPerson712] is_a: WBPhenotype:0000631 ! drug response variant is_a: WBPhenotype:0001852 ! antihelmintic response variant [Term] id: WBPhenotype:0002050 name: abamectin sensitive def: "Animals are do not survive, or become paralyzed in the presence of abamectin." [WB:WBPaper00040740, WB:WBPerson712] is_a: WBPhenotype:0002049 ! abamectin repsonse variant [Term] id: WBPhenotype:0002051 name: ascaroside biosynthesis variant def: "The production or regulation of ascaroside molecule populations differs from that of control animals. " [WB:WBPaper00040624, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0002052 name: ascaroside biosynthesis defective def: "Animals lack the ability to produce ascarosides that are capable of being produced in control animals." [WB:WBPaper00040624, WB:WBPerson712] is_a: WBPhenotype:0002051 ! ascaroside biosynthesis variant [Term] id: WBPhenotype:0002053 name: ivermectin resistant def: "Animals fail to respond to or exhibit an attenuated response to ivermectin under conditions that elicits a response in control animals." [WB:WBPaper00003945, WB:WBPaper00040740, WB:WBPerson712] is_a: WBPhenotype:0000011 ! drug resistant is_a: WBPhenotype:0001856 ! ivermectin response variant [Term] id: WBPhenotype:0002054 name: magnesium hypersensitivity def: "Animals exhibit an exaggerated response to magnesium compared to control animals exposed to similar concentrations." [WB:WBPaper00036046, WB:WBPerson712] is_a: WBPhenotype:0000591 ! metal response variant [Term] id: WBPhenotype:0002055 name: photocurrent defective def: "Animals do not exhibit light-induced currrents to the same extent or with the same quality as control animals." [WB:WBPaper00036207, WB:WBPerson712] is_a: WBPhenotype:0002014 ! current measurement variant [Term] id: WBPhenotype:0002056 name: eating variant def: "Any variation in the specific actions or reactions of an organism causing an alteration in the ingestion of food compared to control animals. In C. elegans the main food source is bacteria and alterations in eating behavior usually lead to malnutrition." [WB:WBPerson557, WB:WBPerson712] synonym: "Eat" EXACT [] is_a: WBPhenotype:0000659 ! feeding behavior variant [Term] id: WBPhenotype:0002057 name: Bacillus thuringiensis toxin hypersensitive def: "Animals respond to Bacillus thuringiensis toxins (Bt toxins) at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0002058 name: pore forming toxin response variant def: "Animals are not affected to the same degree as control animals under similar conditions of pore forming toxin exposure. " [WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0002059 name: pore forming toxin hypersensitive def: "Animals respond to pore forming toxins at a lower concentration or a shorter exposure compared to control animals. Increased susceptibility to pore forming toxins (e.g. Cry5B from Bacillus thuringiensis) is often measured by a decrease in the rate of survival in the presence of pore forming toxins compared to controls." [WB:WBPerson2987, WB:WBPerson557] synonym: "Hpo" BROAD [] synonym: "hypersensitive to pore forming toxin" EXACT [] is_a: WBPhenotype:0000010 ! drug hypersensitive is_a: WBPhenotype:0002058 ! pore forming toxin response variant [Term] id: WBPhenotype:0002060 name: pore forming toxin resistant def: "Animals fail to respond to the concentration of pore forming toxins that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug resistant is_a: WBPhenotype:0002058 ! pore forming toxin response variant [Term] id: WBPhenotype:0002061 name: chromosome decondensation variant def: "Any variation in the progressive decompaction of chromatin that changes chromosome structure from the condensed form to a relaxed disperse form." [GO:0051312, WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0001743 ! mitosis variant is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0002062 name: chromosome decondensation failure def: "The process of decompaction of chromatin that changes chromosome structure from the condensed form to a relaxed disperse form is abolished." [WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0002061 ! chromosome decondensation variant [Term] id: WBPhenotype:0002063 name: maintenance of gene silencing variant def: "Animals differ from controls in the expression of genes targeted for silencing (gene inactivation) in subsequent generations via transcriptional or post-transcriptional processes." [GO:0016458, WB:WBPaper00041239, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0002064 name: maintenance of gene silencing defective def: "Animals express genes that had been targeted for heritable silencing in previous generations." [WB:WBPaper00041239, WB:WBPerson712] is_a: WBPhenotype:0002063 ! maintenance of gene silencing variant [Term] id: WBPhenotype:0002065 name: basement membrane remodeling variant def: "Animals display variations in the manner in which the basement membrane (a thin, dense, sheet-like structure built on a network of polymeric laminin and type IV collagen) is remodeled, compared to control animals." [WB:WBPaper00038447, WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0000200 ! pericellular component development variant [Term] id: WBPhenotype:0002066 name: basement membrane gap expansion variant def: "Animals display variations in the manner in which an opening in the basement membrane (a thin, dense, sheet-like structure built on a network of polymeric laminin and type IV collagen) expands to make way for intertissue connections, compared to control animals." [WB:WBPaper00038447, WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0002065 ! basement membrane remodeling variant [Term] id: WBPhenotype:0002067 name: apical constriction variant def: "Animals differ from control animals in cortical actomyocin dynamics leading to internalization of endodermal precursor cells during gastrulation." [WB:WBPaper00040757, WB:WBPerson712] is_a: WBPhenotype:0000047 ! gastrulation variant [Term] id: WBPhenotype:0002068 name: astral microtubule asymmetry defective def: "There is significantly less difference between the number of astral microtubles or other component(s) of the spindle microtuble organizing center at the anterior versus posterior poles of the spindle, than observed in control animals." [WB:WBPaper00040200, WB:WBPerson712] synonym: "spindle asymmetry defective" RELATED [] is_a: WBPhenotype:0000759 ! spindle defective early emb [Term] id: WBPhenotype:0002069 name: axon termination defective def: "Axons in animals do not end in the same manner as they do in control animals. Some defects described include an overextension of the axon or termination of the axon in the shape of a hook, either large or small." [WB:WBPaper00040220, WB:WBPerson712] is_a: WBPhenotype:0000180 ! axon morphology variant [Term] id: WBPhenotype:0002070 name: egg laying response to muscimol variant def: "Animals do not mimic control animals in their egg-laying response to muscimol exposure. In C. elegans, muscimol inhibits egg-laying." [WB:WBPaper00038249, WB:WBPerson712] is_a: WBPhenotype:0001101 ! egg laying response to drug variant is_a: WBPhenotype:0002047 ! muscimol response variant [Term] id: WBPhenotype:0002071 name: body lengthening response to muscimol variant def: "The length of the animal does not increase to the same extent as observed for control animals, in response to exposure to muscimol." [WB:WBPaper00038249, WB:WBPerson712] is_a: WBPhenotype:0002047 ! muscimol response variant [Term] id: WBPhenotype:0002072 name: carbohydrate metabolism variant def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of carbohydrates within the organism or cell compared to control." [WB:WBPaper00038233, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000027 ! organism metabolism processing variant [Term] id: WBPhenotype:0002073 name: cation homeostasis variant def: "Animals exhibit variations in the regulation of levels, transport, and metabolism of cations within a cell or between a cell and its external environment, compared to control." [WB:WBPaper00036046, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism homeostasis metabolism variant [Term] id: WBPhenotype:0002074 name: centrosome dynamics variant def: "Animals vary in the directed or coordinated movement of their centrosomes during cell division, compared to the pattern of movement observed in control animals." [WB:WBPaper00040172, WB:WBPerson712] is_a: WBPhenotype:0000764 ! embryonic cell organization biogenesis variant [Term] id: WBPhenotype:0002075 name: eggshell formation variant def: "Embryos exhibit variations in the processes that lead to the construction of the eggshell, a protective structure that minimizes water loss whilst allowing gas exchanges essential for embryonic respiration, compared to controls" [GO:0030703, WB:WBPaper00031064, WB:WBPaper00040142, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000041 ! osmotic integrity variant is_a: WBPhenotype:0000728 ! exocytosis variant [Term] id: WBPhenotype:0002076 name: cortical granule exocytosis variant def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a specialized secretory vesicle that fuses with the plasma membrane during egg activation." [GO:0060471, WB:WBPaper00031064, WB:WBPaper00040142, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0002075 ! eggshell formation variant [Term] id: WBPhenotype:0002077 name: dopamine resistant def: "Animals fail to respond to the concentration of a dopamine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00038270, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000011 ! drug resistant [Term] id: WBPhenotype:0002078 name: histone methylation variant def: "The pattern or state of methyl modifications of histone varies from that of controls. " [WB:WBPaper00038409, WB:WBPerson712] synonym: "methylation mark variant" RELATED [] is_a: WBPhenotype:0001383 ! protein methylation variant [Term] id: WBPhenotype:0002079 name: delayed reproductive maturity def: "The animal's ability to reproduce, or start of reproduction occurs later than that observed for control animals." [WB:WBPerson712] is_a: WBPhenotype:0000045 ! developmental delay postembryonic [Term] id: WBPhenotype:0002080 name: peptide uptake by intestinal cell variant def: "Animals exhibit variations in the degree to which or manner in which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals." [WB:WBPerson2987] is_a: WBPhenotype:0001763 ! uptake by intestinal cell defective [Term] id: WBPhenotype:0002081 name: peptide uptake by intestinal cell increased def: "Animals exhibit an increase in the degree to which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals." [WB:WBPerson2987] is_a: WBPhenotype:0002080 ! peptide uptake by intestinal cell variant [Term] id: WBPhenotype:0002082 name: peptide uptake by intestinal cell decreased def: "Animals exhibit a decrease in the degree to which an intestinal cell is able to uptake peptides (for example, di- or tripeptides) from the intestinal lumen, compared to control animals." [WB:WBPerson2987] is_a: WBPhenotype:0002080 ! peptide uptake by intestinal cell variant [Term] id: WBPhenotype:0002083 name: crossover variant def: "The frequency and distribution of crossover events differs from that observed for controls." [WB:WBPaper00037960, WB:WBPerson712] is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0002084 name: crossover interference variant def: "Animals differ from controls in respect to the frequency of expected double crossover events observed. " [WB:WBPaper00037960, WB:WBPerson712] is_a: WBPhenotype:0002083 ! crossover variant [Term] id: WBPhenotype:0002085 name: crossover formation variant def: "The number of crossover events differs from that of observed in control animals. " [WB:WBPaper00037960, WB:WBPerson712] is_a: WBPhenotype:0002083 ! crossover variant [Term] id: WBPhenotype:0002086 name: crossover distribution variant def: "The location-specific frequency of crossover events differs from that of observed in control animals, while the total number of crossover events does not significantly differ." [WB:WBPaper00037960, WB:WBPerson712] is_a: WBPhenotype:0002083 ! crossover variant [Term] id: WBPhenotype:0002087 name: hydrogen sulfide hypersensitive def: "Animals respond to hydrogen sulfide at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00039977, WB:WBPerson712] is_a: WBPhenotype:0000010 ! drug hypersensitive [Term] id: WBPhenotype:0002088 name: hypersensitive to dauer pheromone def: "Animals respond to dauer pheromone at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson712] is_a: WBPhenotype:0001479 ! dauer pheromone sensation variant [Term] id: WBPhenotype:0002089 name: cell component morphology variant def: "Any variation in the form or composition of the basic structural and functional components of cells compared to control. Includes the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, endosomes, lysosomes, and peroxisomes as well as other vesicles and organelles." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0000533 ! cell morphology variant [Term] id: WBPhenotype:0002090 name: endosome morphology variant def: "Any variation in the form or composition of membrane bound organelles, known as endosomes, that traffic material between the plasma membrane and internal compartments of the cell, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0002091 name: late endosome morphology variant def: "Any variation in the form or composition of membrane bound organelles, known as late endosomes, that traffic material from early endosomes to internal compartments of the cell, such as lysosomes or the Golgi apparatus, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002090 ! endosome morphology variant [Term] id: WBPhenotype:0002092 name: early endosome morphology variant def: "Any variation in the form or composition of membrane bound organelles, known as early endosomes, that traffic material from endocytic vesicles (having recently internalized portions of the cell's plasma membrane) to internal compartments of the cell, such as recycling endosomes, late endosomes, or the Golgi apparatus, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002090 ! endosome morphology variant [Term] id: WBPhenotype:0002093 name: recycling endosome morphology variant def: "Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002090 ! endosome morphology variant [Term] id: WBPhenotype:0002094 name: RAB-11 recycling endosome morphology variant def: "Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002093 ! recycling endosome morphology variant [Term] id: WBPhenotype:0002095 name: lysosome-related organelle morphology variant def: "Any variation in the form or composition of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0002096 name: golgi apparatus morphology variant def: "Any variation in the form or composition of membrane bound organelles, known as the Golgi apparatus, that traffic material from the endoplasmic reticulum or various endosomes, and process proteins for secretion, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0002097 name: lysosome morphology variant def: "Any variation in the form or composition of membrane bound organelles, known as lysosomes, that have an acidic interior and generally act to digest components of the cell, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0002098 name: cell component localization variant def: "Any variation in the subcellular localization of the basic structural and functional components of cells compared to control. Includes the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, endosomes, lysosomes, and peroxisomes as well as other vesicles and organelles." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0000533 ! cell morphology variant [Term] id: WBPhenotype:0002099 name: lysosome-related organelle localization variant def: "Any variation in the subcellular localization of membrane bound organelles, known as lysosome-related organelles (LROs) that, like lysosomes, have an acidic interior and generally act to digest components of the cell but are distinct in function, composition, and morphology, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002098 ! cell component localization variant [Term] id: WBPhenotype:0002100 name: endosome localization variant def: "Any variation in the subcellular localization of membrane bound organelles, known as endosomes, that traffic material between the plasma membrane and internal compartments of the cell, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002098 ! cell component localization variant [Term] id: WBPhenotype:0002101 name: endoplasmic reticulum localization variant def: "Any variation in the subcellular localization of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that exists in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002098 ! cell component localization variant [Term] id: WBPhenotype:0002102 name: golgi apparatus localization variant def: "Any variation in the subcellular localization of membrane bound organelles, known as the Golgi apparatus, that traffic material from the endoplasmic reticulum or various endosomes, and process proteins for secretion, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002098 ! cell component localization variant [Term] id: WBPhenotype:0002103 name: lysosome localization variant def: "Any variation in the subcellular localization of membrane bound organelles, known as lysosomes, that have an acidic interior and generally act to digest components of the cell, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002098 ! cell component localization variant [Term] id: WBPhenotype:0002104 name: recycling endosome localization variant def: "Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002100 ! endosome localization variant [Term] id: WBPhenotype:0002105 name: late endosome localization variant def: "Any variation in the subcellular localization of membrane bound organelles, known as late endosomes, that traffic material from early endosomes to internal compartments of the cell, such as lysosomes or the Golgi apparatus, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002100 ! endosome localization variant [Term] id: WBPhenotype:0002106 name: early endosome localization variant def: "Any variation in the subcellular localization of membrane bound organelles, known as early endosomes, that traffic material from endocytic vesicles (having recently internalized portions of the cell's plasma membrane) to internal compartments of the cell, such as recycling endosomes, late endosomes, or the Golgi apparatus, compared to control." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002100 ! endosome localization variant [Term] id: WBPhenotype:0002107 name: RAB-11 recycling endosome localization variant def: "Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the RAB protein RAB-11, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002104 ! recycling endosome localization variant [Term] id: WBPhenotype:0002108 name: cell type morphology variant def: "Any variation in the form or composition of specialized cell types, compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0000533 ! cell morphology variant [Term] id: WBPhenotype:0002109 name: drug susceptible def: "Animals are affected by exposure to the drug." [WB:WBPerson712] is_a: WBPhenotype:0000631 ! drug response variant [Term] id: WBPhenotype:0002110 name: RME-1 recycling endosome morphology variant def: "Any variation in the form or composition of membrane bound organelles, known as recycling endosomes, positive for the endocytosis protein RME-1, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002093 ! recycling endosome morphology variant [Term] id: WBPhenotype:0002111 name: RME-1 recycling endosome localization variant def: "Any variation in the subcellular localization of membrane bound organelles, known as recycling endosomes, positive for the endocytosis protein RME-1, that traffic material from early endosomes back to the plasma membrane of the cell, thereby recycling recently endocytosed material to be reused at the plasma membrane." [WB:WBPaper00041129, WB:WBPerson2987] is_a: WBPhenotype:0002104 ! recycling endosome localization variant [Term] id: WBPhenotype:0002112 name: synapsis maintenance defective def: "Animals are unable to maintain paired chromosome throughout pachytene. " [WB:WBPaper00037960, WB:WBPerson712] is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0002113 name: synapsis formation variant def: "Animals differ from controls in respect to the formation of paired chromosome loci. " [WB:WBPaper00037960, WB:WBPerson712] is_a: WBPhenotype:0002012 ! meiotic chromosome organization variant [Term] id: WBPhenotype:0002114 name: swimming induced paralysis def: "Animals become paralyzed after a measured amount of time swimming. In C. elegans, more then 80 percent of wild-type animals continue swimming vigorously in liquid even after 30 minutes. " [WB:WBPaper00038270, WB:WBPerson712] synonym: "SWIP" BROAD [] is_a: WBPhenotype:0001700 ! swimming variant [Term] id: WBPhenotype:0002115 name: suicidal def: "Animals do not avoid, and perhaps seek, environments that result in their death. In the case of C. elegans, this behavior is exemplified by animals that tend to crawl off the plate." [WB:WBPerson712] is_a: WBPhenotype:0000888 ! male behavior variant [Term] id: WBPhenotype:0002116 name: subviable def: "Animals are barely alive, but not entirely dead." [WB:WBPerson712] is_a: WBPhenotype:0000531 ! organism development variant is_a: WBPhenotype:0000576 ! organism physiology variant [Term] id: WBPhenotype:0002117 name: occurences of decapitation def: "Animals exhibit constrictions in the anterior portion of the head that result in decapitation. " [WB:WBPerson712] is_a: WBPhenotype:0000212 ! body constriction [Term] id: WBPhenotype:0002118 name: population fitness variant def: "Populations exhibit variations in the ability to survive, grow and reproduce, thus affecting the contribution to the gene pool over generations compared to control populations. In C. elegans the fitness of a population can by assessed by measuring the rate at which E. coli is consumed." [WB:WBPaper00040316, WB:WBPaper00040815, WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0000519 ! physiology variant [Term] id: WBPhenotype:0002119 name: alternative splicing defective def: "The process of generating multiple mRNA molecules from differential use of exons in a primary transcript(s) does not occur or occurs with outcomes not observed in control animals." [WB:WBPerson1686, WB:WBPerson712] is_a: WBPhenotype:0001807 ! alternative splicing variant [Term] id: WBPhenotype:0002120 name: mitochondrial DNA repair variant def: "Any variation in the process of restoring mitochondrial DNA after damage." [GO:0043504, WB:WBPerson557] is_a: WBPhenotype:0001938 ! DNA repair variant [Term] id: WBPhenotype:0002121 name: heteroplasmy def: "The presence of a mixture of more than one type of an organellar genome (mitochondrial DNA (mtDNA) or plastid DNA) within a cell or individual. " [WB:WBPaper00040387, WB:WBPerson2987] is_a: WBPhenotype:0000576 ! organism physiology variant [Term] id: WBPhenotype:0002122 name: persistence of paternal mitochondria def: "Mitochondria from spermatazoa persist in the developing embryo and animal as a result of bypassing the degradation mechanism that normally destroys paternal mitochondria immediately after fertilization. This can often lead to a form of heteroplasmy." [WB:WBPaper00040387, WB:WBPerson2987] is_a: WBPhenotype:0002121 ! heteroplasmy [Term] id: WBPhenotype:0002123 name: histone acetylation variant def: "The pattern or state of acetylation modifications of histones varies from that of controls." [WB:WBPaper00040843, WB:WBPerson2987] is_a: WBPhenotype:0001917 ! protein acetylation variant [Term] id: WBPhenotype:0002124 name: circumferential actin bundles disorganized def: "The distribution or presence of actin in circumferential actin bundles (CFB) differs from that observed in control animals. Contraction of CFBs provide the driving force for epidermal elongation." [WB:WBPaper00006290, WB:WBPerson712] is_a: WBPhenotype:0001587 ! actin organization biogenesis variant [Term] id: WBPhenotype:0002125 name: growth inhibition response to chemical def: "Animals do not grow fast or the quality of growth is decreased when exposed to a specific chemical compound when compared to control animals." [WB:WBPaper00040519, WB:WBPerson712] is_a: WBPhenotype:0000523 ! chemical response variant [Term] id: WBPhenotype:0002126 name: intestinal fluorescence decreased def: "Animals exhibit a decrease in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine." [WB:WBPerson712] is_a: WBPhenotype:0000293 ! alimentary system pigmentation variant [Term] id: WBPhenotype:0002127 name: intraflagellar transport velocity variant def: "Animals exhibit variation rate of directed movement of organelles or molecules along microtubules in nerve cell axons, compared to control." [WB:WBPaper00038442, WB:WBPerson712] is_a: WBPhenotype:0000853 ! intraflagellar transport variant [Term] id: WBPhenotype:0002128 name: leaving assay defective def: "Males remain on food in the absence of mates, a defect in male mate-searching behavior observed in control males. " [WB:WBPaper00041718, WB:WBPerson712] synonym: "Las" BROAD [] is_a: WBPhenotype:0001983 ! lawn leaving behavior variant is_a: WBPhenotype:0004031 ! mate searching variant [Term] id: WBPhenotype:0002129 name: mitochondrial DNA copy number variant def: "Relative levels of mtDNA differ from that observed for control animals." [WB:WBPaper00032112, WB:WBPerson712] is_a: WBPhenotype:0000732 ! DNA metabolism variant is_a: WBPhenotype:0001282 ! mitochondrial metabolism variant [Term] id: WBPhenotype:0002130 name: post mating variant def: "Males exhibit variations of the behaviors observed in control animals that follow the completion of mating." [WB:WBPaper00041718, WB:WBPerson712] synonym: "mate experience variant" RELATED [] is_a: WBPhenotype:0000648 ! male mating variant [Term] id: WBPhenotype:0002131 name: muscle cell ultrastructure variant def: "Animals display variations in the structure or organization of the components of the muscle, compared to that observed in control animals." [WB:WBPerson712] is_a: WBPhenotype:0000904 ! muscle cell morphology variant [Term] id: WBPhenotype:0002132 name: protein complex organization variant def: "The formation, organization, or stability of a protein complex is altered in comparison to corresponding complexes in control animals." [WB:WBPaper00038066, WB:WBPerson712] synonym: "protein clustering variant " RELATED [] is_a: WBPhenotype:0001370 ! protein protein interaction variant [Term] id: WBPhenotype:0002133 name: ooplasmic streaming slow def: "The bulk flow of cytoplasm in the egg, that facilitates mixing of ooplasm, occurs at a reduced rate compared to that measured for controls." [WB:WBPerson712] is_a: WBPhenotype:0000360 ! cytoplasmic streaming defective [Term] id: WBPhenotype:0002134 name: predator escape defective def: "Animals are less successful than controls in evading predators during predator-prey interactions." [WB:WBPaper00039982, WB:WBPerson712] is_a: WBPhenotype:0002135 ! organism predator response variant [Term] id: WBPhenotype:0002135 name: organism predator response variant def: "Predator-prey interactions differ from that observed in control interactions. " [WB:WBPaper00039982, WB:WBPerson712] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0002136 name: no anchor cell def: "Animals are missing the anchor cell. In C. elegans the anchor cell is a key organizer of vulval patterning and morphogenesis." [WB:WBPaper00003577, WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0000399 ! somatic gonad development variant [Term] id: WBPhenotype:0002137 name: reduced translation initiation def: "The rate of the process preceding formation of the peptide bond between the first two amino acids of a protein is reduced. This process includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. Increase in free ribosomes (monosomes) are indicative of reduced translation initiation." [GO:0006413, WB:WBPaper00039835, WB:WBPerson557] is_a: WBPhenotype:0000121 ! translation variant [Term] id: WBPhenotype:0002138 name: acquired thermotolerance variant def: "Animals are altered in their capacity to survive a normally lethal temperature treatment as a consequence of pretreatment at an elevated but sublethal temperature." [WB:WBPaper00040849, WB:WBPerson557] is_a: WBPhenotype:0000146 ! organism temperature response variant [Term] id: WBPhenotype:0002139 name: linker cell morphology variant def: "Any variation in the morphological appearance of the linker cell compared to control animals." [WB:WBPaper00035457, WB:WBPerson557] is_a: WBPhenotype:0002108 ! cell type morphology variant [Term] id: WBPhenotype:0002140 name: male attraction response variant def: "Males do not respond to small molecules or compounds that have been shown to attract control males. This phenotype is often measured by an increase in reversal frequency or time spent in a specified scoring region" [WB:WBPaper00032050, WB:WBPerson712] is_a: WBPhenotype:0000738 ! organism environmental stimulus response variant [Term] id: WBPhenotype:0002141 name: oxygen consumption variant def: "Variations in the process of gaseous oxygen intake between an organism and its environment compared to control animals." [WB:WBPaper00042217, WB:WBPerson557] is_a: WBPhenotype:0001835 ! energy expenditure variant [Term] id: WBPhenotype:0002142 name: mitochondrial respiratory chain variant def: "The activity, composition, or organization of the complexes of the electron transport chain, embedded in the inner mitochondrial membrane, differ from controls." [GO:0005746, WB:WBPaper00042217, WB:WBPerson712] synonym: "mitochondrial electron transport chain variant" EXACT [] synonym: "MRC variant" EXACT [] is_a: WBPhenotype:0001282 ! mitochondrial metabolism variant [Term] id: WBPhenotype:0002143 name: mitochondrial respiratory complex II variant def: "The part of the respiratory chain that catalyzes the oxidation of succinate and connects the TCA cycle with the respiratory chain, differs in activity, composition, or organization, from that of controls." [GO:0045273, WB:WBPaper00042217, WB:WBPerson712] synonym: "CO II variant" EXACT [] synonym: "Complex II variant" EXACT [] synonym: "Succinate dehydrogenase complex variant " EXACT [] is_a: WBPhenotype:0002142 ! mitochondrial respiratory chain variant [Term] id: WBPhenotype:0002144 name: mitochondrial respiratory complex I variant def: "The protein complex located in the mitochondrial inner membrane that is the first entry point for electrons into the electron transport chain and catalyzes proton translocation coupled to the oxidation of NADH by ubiquinone, differs in activity, composition, or organization from that of controls." [GO:0005747, WB:WBPaper00042217, WB:WBPerson712] synonym: "CO I variant" EXACT [] synonym: "Complex I variant" EXACT [] synonym: "NADH dehydrogenase complex variant" EXACT [] synonym: "Ubiquinone complex variant" EXACT [] is_a: WBPhenotype:0002142 ! mitochondrial respiratory chain variant [Term] id: WBPhenotype:0002145 name: siRNA processing defective def: "Animals are unable to produce or maintain short interfering RNA (siRNA) from double stranded RNA (dsRNA). siRNAs are required to initiate interference of gene expression." [WB:WBPaper00027057, WB:WBPerson712] is_a: WBPhenotype:0000743 ! RNAi response variant is_a: WBPhenotype:0001776 ! siRNA expression variant [Term] id: WBPhenotype:0002146 name: small RNA germline expression variant def: "Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of any class of small RNA species in the germline. Small RNAs include microRNAs (miRNAs), tiny noncoding RNAs (tncRNAs), cluster of small X-chromosome derived RNAs (X cluster), and endogenous short interfering RNA (endo-siRNAs)." [WB:WBPaper00027057, WB:WBPerson712] is_a: WBPhenotype:0000113 ! RNA expression variant [Term] id: WBPhenotype:0002147 name: small RNA somatic expression variant def: "Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of any class of small RNA species in somatic cells. Small RNAs include microRNAs (miRNAs), tiny noncoding RNAs (tncRNAs), cluster of small X-chromosome derived RNAs (X cluster), and endogenous short interfering RNA (endo-siRNAs)." [WB:WBPaper00027057, WB:WBPerson712] is_a: WBPhenotype:0000113 ! RNA expression variant [Term] id: WBPhenotype:0002148 name: somatic RNAi resistant def: "Animals show reduced susceptibility to gene silencing in somatic cells triggered by double stranded RNA (dsRNA), compared to control." [WB:WBPaper00027057, WB:WBPerson712] is_a: WBPhenotype:0001208 ! RNAi resistant [Term] id: WBPhenotype:0002149 name: X cluster small RNA expression variant def: "Animals exhibit variations from controls in the expression, biogenesis, processing, or stability of the small X-chromosome derived RNAs (X cluster) species of small RNA." [WB:WBPaper00027057, WB:WBPerson712] is_a: WBPhenotype:0000113 ! RNA expression variant [Term] id: WBPhenotype:0002150 name: exo-RNAi response variant def: "RNAi silencing mechanisms triggered by exogenously introduced (foreign) dsRNA, do not work to the same degree as in control animals." [WB:WBPaper00027057, WB:WBPerson712] is_a: WBPhenotype:0000743 ! RNAi response variant [Term] id: WBPhenotype:0002151 name: mRNA deadenylation variant def: "Animals exhibit variations in the extent to which polyadenylated mRNA transcripts become deadenylated" [WB:WBPaper00037823, WB:WBPerson2987] is_a: WBPhenotype:0001827 ! RNA metabolism variant [Term] id: WBPhenotype:0002152 name: mutagen induced apoptosis variant def: "Programmed cell death of germ cells caused by exposure to physical or chemical DNA-damaging agents does not occur to the same extent as it does in control animals." [WB:WBPerson712] is_a: WBPhenotype:0000730 ! apoptosis variant [Term] id: WBPhenotype:0002153 name: dsRNA processing defective def: "The production of silencing RNA from dsRNA is significantly deficient compared to controls. Deficiencies in this process can result in a defective RNAi response compared to controls." [WB:WBPaper00029211, WB:WBPerson712] is_a: WBPhenotype:0000028 ! RNA processing variant [Term] id: WBPhenotype:0002154 name: polysome mRNA association variant def: "The extent of mRNA ribosome associations varies from controls. " [WB:WBPaper00032489, WB:WBPerson712] is_a: WBPhenotype:0000121 ! translation variant is_a: WBPhenotype:0001371 ! protein RNA interaction variant [Term] id: WBPhenotype:0002155 name: pre-miRNA processing defective def: "The production of mature miRNA from pre-miRNA is significantly deficient compared to controls. Deficiencies in this process can result in the accumulation of pre-miRNA species and or the absence or smaller amount of mature miRNA compared to controls." [WB:WBPaper00029211, WB:WBPerson712] is_a: WBPhenotype:0000028 ! RNA processing variant is_a: WBPhenotype:0001779 ! miRNA expression variant [Term] id: WBPhenotype:0002156 name: temperature learning variant def: "Wild-type animals will exhibit an altered temperature preference based on food/temperature conditioning. Temperature learning variants do not exhibit altered responses to temperature after conditioning compared to control animals." [WB:WBPaper00031647, WB:WBPerson712] is_a: WBPhenotype:0001780 ! associative learning variant [Term] id: WBPhenotype:0002157 name: translation repression variant def: "The extent of translational repression varies from controls." [WB:WBPaper00032489, WB:WBPerson712] is_a: WBPhenotype:0000121 ! translation variant [Term] id: WBPhenotype:0002158 name: P granule degradation defective def: "The selective elimination of P granule components and subsequent aggregation of degraded components into PGL granules is disrupted." [WB:WBPaper00044350, WB:WBPerson712] is_a: WBPhenotype:0001301 ! P granule defective [Term] id: WBPhenotype:0002159 name: increased pathogen accumulation def: "Animals exhibit an increase in pathogen accumulation, persistent colonization, and luminal distension of the intestine." [WB:WBPaper00032276, WB:WBPerson2987] is_a: WBPhenotype:0001819 ! pathogen load variant [Term] id: WBPhenotype:0002160 name: intraflagellar transport complex destabilized def: "The intracellular complex of proteins that participates in bidirectional transport of molecules (cargo) along axonemal microtubules is not made up of or does not maintain the proper number or ratio of components as found in control animals." [WB:WBPaper00042072, WB:WBPerson712] is_a: WBPhenotype:0002132 ! protein complex organization variant [Term] id: WBPhenotype:0002161 name: mitotic chromatin remodeling variant def: "Animals exhibit variations from controls in the organization of chromatin, including in relation to associated complexes, that occur during the mitotic cell division cycle." [GO:0006338, WB:WBPaper00040620, WB:WBPerson712] is_a: WBPhenotype:0001348 ! chromosome morphology variant is_a: WBPhenotype:0001743 ! mitosis variant [Term] id: WBPhenotype:0002162 name: multipolar mitotic spindle def: "Cells exhibit mitotic spindles with more than two poles. " [WB:WBPaper00038412, WB:WBPerson712] synonym: "multipolar mitosis" RELATED [] is_a: WBPhenotype:0001215 ! germ cell mitosis variant is_a: WBPhenotype:0001743 ! mitosis variant [Term] id: WBPhenotype:0002163 name: oxygen consumption decreased def: "Animals exhibit a decreased rate of oxygen utilization compared to control animals." [WB:WBPaper00036073, WB:WBPerson712] is_a: WBPhenotype:0002141 ! oxygen consumption variant [Term] id: WBPhenotype:0002164 name: innate immune response variant def: "Animals exhibit variations in their defense responses that are mediated by germline encoded components that directly recognize components of potential pathogens." [GO:0045087, WB:WBPerson557] is_a: WBPhenotype:0001012 ! organism pathogen response variant [Term] id: WBPhenotype:0004001 name: hermaphrodite mating variant def: "Any variation in the specific actions or reactions of a hermaphrodite during mating compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite mating abnormal" NARROW [] is_a: WBPhenotype:0000647 ! copulation variant is_a: WBPhenotype:0000887 ! hermaphrodite behavior variant [Term] id: WBPhenotype:0004002 name: attraction signal defective def: "Animals exhibit defects in the production of the sensory signal to attract males." [WB:WBPaper00005109, WB:WBPerson557] is_a: WBPhenotype:0004015 ! pre male contact variant [Term] id: WBPhenotype:0004003 name: mate finding defective def: "Males exhibit defects in their response to the mate-finding cue." [WB:WBPaper00005109, WB:WBPerson557] synonym: "mate finding abnormal" NARROW [] synonym: "response to male attractant abnormal" RELATED [] is_a: WBPhenotype:0004005 ! pre hermaphrodite contact variant [Term] id: WBPhenotype:0004004 name: male response to contact defective def: "The inability of a male to respond properly to a potential mate after contact. In C.elegans, proper response includes apposing the ventral side of his tail to the hermaphrodite's body and swimming backward." [GO:0034606, WB:WBPaper00000392, WB:WBPaper00002109, WB:WBPerson557] is_a: WBPhenotype:0001414 ! male mating defective is_a: WBPhenotype:0004006 ! post hermaphrodite contact variant [Term] id: WBPhenotype:0004005 name: pre hermaphrodite contact variant def: "Males exhibit variations in mating behavior prior to contacting its mate compared to control." [WB:WBPerson557] synonym: "pre hermaphrodite contact abnormal" NARROW [] is_a: WBPhenotype:0000648 ! male mating variant [Term] id: WBPhenotype:0004006 name: post hermaphrodite contact variant def: "Males exhibit variations in mating behavior after contacting its mate compared to control." [WB:WBPerson557] synonym: "post hermaphrodite contact abnormal" NARROW [] is_a: WBPhenotype:0000648 ! male mating variant [Term] id: WBPhenotype:0004007 name: periodic spicule prodding defective def: "Males exhibit defects in the continuous prodding of spicule tips at the vulva prior to prolonged spicule insertion." [GO:0034609, WB:WBPerson2021, WB:WBPerson557] synonym: "spicule prodding defective" RELATED [] is_a: WBPhenotype:0000279 ! spicule insertion defective [Term] id: WBPhenotype:0004008 name: sustained spicule protraction defective def: "Males exhibit defects in the prolonged, tonic, spicule extrusion through the vulva prior to sperm transfer." [GO:0034609, WB:WBPerson2021, WB:WBPerson557] synonym: "prolonged spicule protraction defective" RELATED [] is_a: WBPhenotype:0000279 ! spicule insertion defective [Term] id: WBPhenotype:0004009 name: approximate vulval location variant def: "Any variation in the mating process that includes the male stopping at the vulva (usually after backing) compared to control. In C. elegans general vulva location (stopping) requires the hook sensillum." [WB:WBPaper00002109, WB:WBPerson2021, WB:WBPerson557] synonym: "approximate vulval location abnormal" NARROW [] synonym: "general vulval location abnormal" RELATED [] is_a: WBPhenotype:0000649 ! vulva location variant [Term] id: WBPhenotype:0004010 name: precise vulval location variant def: "Any variation in the mating process that includes the male positioning his tail precisely over the vulva so that he may insert his spicules and ejaculate compared to control. In C. elegans precise vulva location (coordinating movement and tail positioning) requires the post cloacal sensillium and the spicules." [WB:WBPaper00002109, WB:WBPerson2021, WB:WBPerson557] synonym: "precise vulval location abnormal" NARROW [] is_a: WBPhenotype:0000649 ! vulva location variant [Term] id: WBPhenotype:0004011 name: sperm transfer cessation defective def: "Any variation in the retraction of spicules after all sperm that exit the seminal vesicle have been released compared to control." [WB:WBPaper00028400] is_a: WBPhenotype:0000284 ! sperm transfer defective [Term] id: WBPhenotype:0004012 name: sperm transfer continuation defective def: "Any variation in the continued movement of sperm through the vas deferens, exiting the cloaca, compared to control. In C. elegans, when all sperm that exit the seminal vesicle have been released, the spicules retract into the male." [WB:WBPaper00028400] is_a: WBPhenotype:0000284 ! sperm transfer defective [Term] id: WBPhenotype:0004013 name: sperm release defective def: "Any variation in the initial movement of sperm through the vas deferens, exiting the cloaca, compared to control." [WB:WBPaper00028400] is_a: WBPhenotype:0000284 ! sperm transfer defective [Term] id: WBPhenotype:0004014 name: post male contact variant def: "Any variation in the specific actions or reactions of a hermaphrodite after male contact during mating compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "post male contact abnormal" NARROW [] is_a: WBPhenotype:0004001 ! hermaphrodite mating variant [Term] id: WBPhenotype:0004015 name: pre male contact variant def: "Any variation in the specific actions or reactions of a hermaphrodite prior to male contact during mating compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "pre male contact abnormal" NARROW [] is_a: WBPhenotype:0004001 ! hermaphrodite mating variant [Term] id: WBPhenotype:0004016 name: dauer nictation behavior variant def: "Any variation in the behavior exhibited by dauer larva in which they crawl up upon the substrate and wave back and forth while standing on their tail compared to control. Nictation is often associated with the search for a new host." [WB:WBPaper00027241, WB:WBPerson2021, WB:WBPerson557] synonym: "dauer nictation behavior abnormal" NARROW [] is_a: WBPhenotype:0001001 ! dauer behavior variant [Term] id: WBPhenotype:0004017 name: locomotor coordination variant def: "Animals exhibit variations in their ability to maintain characteristic and effective locomotion compared to control." [WB:WBperson557] synonym: "locomotor coordination abnormal" NARROW [] is_a: WBPhenotype:0000643 ! locomotion variant [Term] id: WBPhenotype:0004018 name: sinusoidal movement variant def: "Any variation in the propagation of the contraction sine wave along the body while an animal travels from one location to another, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "sinusoidal movement abnormal" NARROW [] is_a: WBPhenotype:0004017 ! locomotor coordination variant [Term] id: WBPhenotype:0004022 name: amplitude of movement variant def: "Any variation in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "amplitude of movement abnormal" NARROW [] is_a: WBPhenotype:0004018 ! sinusoidal movement variant [Term] id: WBPhenotype:0004023 name: frequency of body bend variant def: "Animals exhibit variations in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson557, WB:WBPerson712] synonym: "bending frequency abnormal" RELATED [] synonym: "frequency of body bend abnormal" NARROW [] is_a: WBPhenotype:0001703 ! body bend variant [Term] id: WBPhenotype:0004024 name: wavelength of movement variant def: "Any variation in the distance in the line of advance of a body wave from any one point to the next point of corresponding phase compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "wavelength of movement abnormal" NARROW [] is_a: WBPhenotype:0004018 ! sinusoidal movement variant [Term] id: WBPhenotype:0004025 name: velocity of movement variant def: "Animals exhibit variations in the net velocity of an animal, that is, the maximum distance an animal traverses over an extended period of time, from that observed for control animals." [WB:WBPaper00032008, WB:WBPerson712] synonym: "velocity of movement abnormal" NARROW [] is_a: WBPhenotype:0004018 ! sinusoidal movement variant [Term] id: WBPhenotype:0004026 name: nose touch variant def: "Variations in the ability of an animal to respond with characteristic backward movement after a nose-on collision with an object compared to control. In C. elegans, this phenotype is usually assayed via stroking with a hair or similar fiber on the anterior most tip of the animal." [WB:WBPaper00001705, WB:WBPerson557] synonym: "nose touch abnormal" NARROW [] is_a: WBPhenotype:0000315 ! mechanosensation variant [Term] id: WBPhenotype:0004027 name: plate tap reflex variant def: "Animals exhibit variations in their response to substrate vibration compared to control." [WB:WBPerson557] synonym: "plate tap reflex abnormal" NARROW [] is_a: WBPhenotype:0000315 ! mechanosensation variant [Term] id: WBPhenotype:0004028 name: slowing response on food variant def: "Animals exhibit variations in modulating their locomotory rate in response to its food , compared to control. Basal slowing response refers to when well-fed animals move more slowly in the presence of bacteria than in the absence of bacteria . Second , food-deprived control animals , when transferred to bacteria , display a dramatically enhanced slowing response that ensures that the animals do not leave their newly encountered source of food." [WB:WBPaper00004195, WB:WBPerson2021] synonym: "slowing response on food abnormal" NARROW [] is_a: WBPhenotype:0000315 ! mechanosensation variant [Term] id: WBPhenotype:0004029 name: sexually dimorphic mechanosensation variant def: "Any variation with respect to perception or response to mechanical stimuli in a sex dependent manner compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "sexually dimorphic mechanosensation abnormal" NARROW [] is_a: WBPhenotype:0000315 ! mechanosensation variant [Term] id: WBPhenotype:0004030 name: male response to hermaphrodite variant def: "Any variation in the response by the male to a hermaphrodite after initial contact following mate finding compared to control. In C. elegans the male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [GO:0034606, WB:WBPaper00002109, WB:WBPerson2021, WB:WBPerson557] synonym: "male response to hermaphrodite abnormal" NARROW [] synonym: "Rsp" BROAD [] is_a: WBPhenotype:0004029 ! sexually dimorphic mechanosensation variant [Term] id: WBPhenotype:0004031 name: mate searching variant def: "Any variation in the ability of an animal to search for a mate compared to control. In C. elegans, this is defined by failure of the leaving assay." [WB:WBPaper00024428] synonym: "mate searching abnormal" NARROW [] is_a: WBPhenotype:0004005 ! pre hermaphrodite contact variant [Term] id: WBPhenotype:0006001 name: squashed vulva def: "The apparent partial collapse of the vulval invagination and the elongation of central vulva cells often leading to a flattened appearance." [WB:WBPaper00003405] synonym: "Sqv" BROAD [] is_a: WBPhenotype:0000510 ! vulval invagination variant L4 [Term] id: WBPhenotype:0008001 name: embryonic cell fate specification variant def: "Any variation in the processes that govern acquisition of particular cell fates in the embryo, from the time of zygote formation until hatching compared to control." [WB:kmva] synonym: "embryonic cell fate specification abnormal" NARROW [] is_a: WBPhenotype:0000216 ! cell fate specification variant is_a: WBPhenotype:0000749 ! embryonic development variant [Term] id: WBPhenotype:0008002 name: embryonic somatic cell fate specification variant def: "Any variation in the processes that govern acquisition of somatic cell fates in the embryo, from the time of zygote formation until hatching compared to control." [WB:kmva] synonym: "embryonic somatic cell fate specification abnormal" NARROW [] is_a: WBPhenotype:0008001 ! embryonic cell fate specification variant [Term] id: WBPhenotype:0008003 name: odorant imprinting variant def: "Any variation in a learned olfactory response whereby exposure of animals to odorants during specific developmental times or physiological states results in a lasting memory compared to control. In control animals, this imprinting determines the animal's behavior upon encountering the same odorant at a later time." [WB:WBPaper00026662, WB:WBPerson1843] synonym: "odorant imprinting abnormal" NARROW [] synonym: "olfactory imprinting abnormal" EXACT [] is_a: WBPhenotype:0001048 ! odorant chemosensory response variant [Term] id: WBPhenotype:0010001 name: cell growth variant def: "Variations in the process(es) by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter compared to control." [GO:0016049, WB:rk] subset: phenotype_slim_wb synonym: "cell growth abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell physiology variant [Term] id: WBPhenotype:0010002 name: cell organization biogenesis variant def: "Variations in the process(es) involved in the assembly and arrangement of cell structures compared to control." [GO:0016043, WB:rk] subset: phenotype_slim_wb synonym: "cell organization biogenesis abnormal" NARROW [] is_a: WBPhenotype:0002089 ! cell component morphology variant [Term] id: WBPhenotype:0010003 name: cell corpse appearance delayed def: "Animals exhibit a decreased rate programmed cell death pathway leading to the destruction of the cell, viewable in its terminally dismanteled form of a cell corpse, compared to that observed for control cells." [WB:rk, WB:WBPerson712] is_a: WBPhenotype:0000185 ! apoptosis protracted is_a: WBPhenotype:0000438 ! retarded heterochronic variations [Term] id: WBPhenotype:0010004 name: cell corpse degradation variant def: "Variations in the process(es) that constitute cell corpse degradation within the engulfing cell compared to control." [WB:rk] synonym: "cell corpse degradation abnormal" NARROW [] xref: WB:rk is_a: WBPhenotype:0000730 ! apoptosis variant [Typedef] id: is_a name: is_a subset: phenotype_slim_wb is_transitive: true