format-version: 1.2 date: 31:07:2008 14:30 saved-by: garys auto-generated-by: OBO-Edit 1.002 subsetdef: phenotype_slim_wb "WB phenotype slim" synonymtypedef: three_letter_name "Short_name" BROAD default-namespace: C_elegans_phenotype_ontology [Term] id: WBPhenotype:0000000 name: chromosome_instability def: "Animals exhibit a genetic instability due to chromosome alterations such as increases in the frequencies of translocations, deletions, or gene amplifications and increases in chromosome fusion events and or chromosomal loss." [WB:WBPerson712] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000001 name: body_posture_abnormal def: "Characteristic sinusoidal body posture is altered." [WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000002 name: kinker is_a: WBPhenotype:0004017 ! locomotor_coordination_abnormal [Term] id: WBPhenotype:0000004 name: constitutive_egg_laying def: "Eggs are laid in M9, normally an inhibitor of egg laying." [WB:cab] comment: Liquid M9. synonym: "Egl_c" BROAD three_letter_name [] is_a: WBPhenotype:0000005 ! hyperactive_egg_laying [Term] id: WBPhenotype:0000005 name: hyperactive_egg_laying def: "Eggs are laid at an earlier stage of development, eggs are laid in the presence of inhibitors of egg laying, or the inactive phase of the egg-laying cycle is significantly shorter when compared to wild type." [WB:cab] is_a: WBPhenotype:0000640 ! egg_laying_abnormal [Term] id: WBPhenotype:0000006 name: egg_laying_defective def: "Eggs are laid at a slower rate or eggs are laid at a later stage of development (post-gastrulation)." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPaper00025054] synonym: "Egl_D" BROAD three_letter_name [] is_a: WBPhenotype:0000640 ! egg_laying_abnormal [Term] id: WBPhenotype:0000007 name: bag_of_worms def: "A worm carcass is formed with retained eggs that hatch inside." [WB:cab] is_a: WBPhenotype:0000862 ! bloated [Term] id: WBPhenotype:0000008 name: anesthetic_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive is_a: WBPhenotype:0000627 ! anesthetic_response_abnormal [Term] id: WBPhenotype:0000009 name: anesthetic_resistant is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0000627 ! anesthetic_response_abnormal [Term] id: WBPhenotype:0000010 name: drug_hypersensitive is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0000011 name: drug_resistant is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0000012 name: dauer_constitutive def: "Any abnormality that results in the formation of dauer larvae under otherwise favorable environmental, or growth, conditions." [WB:kmva] synonym: "Daf_c" BROAD three_letter_name [] is_a: WBPhenotype:0000637 ! dauer_formation_abnormal [Term] id: WBPhenotype:0000013 name: dauer_defective def: "Any abnormality that results in failure to form dauer larvae under dauer-inducing conditions." [WB:kmva] is_a: WBPhenotype:0000637 ! dauer_formation_abnormal [Term] id: WBPhenotype:0000014 name: cord_commissures_abnormal def: "Animals display deviations in the structure, organization or path of axon tracts that grow circumferentially around the animal in a single, directed trajectory to bridge the ventral and dorsal cords, compared to that in normal animals. " [WB:WBPaper00001499, WB:WBPaper00029065, WB:WBPerson712] is_a: WBPhenotype:0001226 ! commissure_abnormal [Term] id: WBPhenotype:0000015 name: positive_chemotaxis_defective def: "Failure to move towards typically attractive chemicals." [WB:cab] is_a: WBPhenotype:0000635 ! positive_chemotaxis_abnormal [Term] id: WBPhenotype:0000016 name: aldicarb_hypersensitive synonym: "Hic" BROAD three_letter_name [] is_a: WBPhenotype:0000500 ! acetylcholinesterase_inhibitor_hypersensitive is_a: WBPhenotype:0000680 ! aldicarb_response_abnormal [Term] id: WBPhenotype:0000017 name: aldicarb_resistant synonym: "Ric" BROAD three_letter_name [] is_a: WBPhenotype:0000680 ! aldicarb_response_abnormal is_a: WBPhenotype:0001289 ! acetylcholinesterase_inhibitor_resistant [Term] id: WBPhenotype:0000018 name: pharyngeal_pumping_increased is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_abnormal [Term] id: WBPhenotype:0000019 name: pharyngeal_pumping_reduced def: "Pharyngeal pumping motion occurs at a slower rate than wild-type." [WB:WBPaper00001709] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_abnormal [Term] id: WBPhenotype:0000020 name: pharyngeal_pumping_irregular def: "Pharyngeal pumping motion occurs at irregular intervals (as opposed to the uniform intervals in wild-type)." [WB:WBPaper00001709] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_abnormal [Term] id: WBPhenotype:0000021 name: squat def: "Squat animals are dumpy as homozygotes, but roll as heterozygotes." [WB:WBPaper00000906] synonym: "Sqt" BROAD three_letter_name [] is_a: WBPhenotype:0000231 ! body_size_abnormal [Term] id: WBPhenotype:0000022 name: long def: "Animals are longer and thinner than wild-type animals." [WB:cab, WB:cgc31] synonym: "Lon" BROAD three_letter_name [] is_a: WBPhenotype:0000231 ! body_size_abnormal [Term] id: WBPhenotype:0000023 name: serotonin_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000024 name: serotonin_resistant is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000025 name: blistered def: "Fluid-filled blisters appear on the cuticle." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497] synonym: "Bli" BROAD three_letter_name [] is_a: WBPhenotype:0000948 ! cuticle_morphology_abnormal [Term] id: WBPhenotype:0000026 name: lipid_depleted synonym: "fat_depleted" RELATED [] synonym: "Lpd" RELATED [] is_a: WBPhenotype:0001183 ! fat_content_reduced [Term] id: WBPhenotype:0000027 name: organism_metabolism_processing_abnormal is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000028 name: RNA_processing_abnormal is_a: WBPhenotype:0000113 ! RNA_expression_abnormal [Term] id: WBPhenotype:0000029 name: systemic_RNAi_abnormal def: "Animals are defective for RNAi introduced by environmental means such as in the cases of RNAi triggered by soaking or feeding." [WB:WBPaper00029209, WB:WBPaper00030758, WB:WBPerson712] synonym: "Environmental RNAi defective" RELATED [] is_a: WBPhenotype:0000743 ! RNAi_response_abnormal [Term] id: WBPhenotype:0000030 name: growth_abnormal def: "Any perturbation in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during all development stages." [GO:0040007, WB:WBPerson2021] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000031 name: slow_growth def: "Any abnormality that causes a reduction in growth rate." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557] synonym: "Gro" BROAD three_letter_name [] is_a: WBPhenotype:0000030 ! growth_abnormal [Term] id: WBPhenotype:0000032 name: sick def: "Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712] synonym: "Sck" BROAD three_letter_name [] is_a: WBPhenotype:0000030 ! growth_abnormal [Term] id: WBPhenotype:0000033 name: developmental_timing_abnormal alt_id: WBPhenotype:0000437 def: "The timing of specific developmental events in some tissues is altered relative to the timing of events in other tissues." [pmid:6494891, WB:cab] subset: phenotype_slim_wb synonym: "heterochronic_defect" EXACT [] is_a: WBPhenotype:0000531 ! organism_development_abnormal [Term] id: WBPhenotype:0000034 name: embryonic_polarity_abnormal def: "Contents or structures of an embryonic cell are no longer restricted/localized to their typical positions (or poles) within the cell." [WB:WBPaper00005079, WB:WBPerson2021, WB:WBPerson712] is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000035 name: larval_body_morphology_abnormal subset: phenotype_slim_wb synonym: "larval_morphology_abnormal" RELATED [] is_a: WBPhenotype:0000072 ! body_morphology_abnormal is_a: WBPhenotype:0000934 ! developmental_morphology_abnormal [Term] id: WBPhenotype:0000036 name: adult_body_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000072 ! body_morphology_abnormal is_a: WBPhenotype:0000934 ! developmental_morphology_abnormal [Term] id: WBPhenotype:0000037 name: egg_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000934 ! developmental_morphology_abnormal [Term] id: WBPhenotype:0000038 name: exploded_through_vulva def: "The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture." [WB:WBPaper00027633, WB:WBPaper00031094, WB:WBPerson712] synonym: "gonad_eversion" RELATED [] synonym: "gonad_exploded_through_vulva" RELATED [] synonym: "Rup" BROAD three_letter_name [] is_a: WBPhenotype:0000619 ! epithelial_system_development_abnormal [Term] id: WBPhenotype:0000039 name: life_span_abnormal def: "Adult life span is either longer or shorter than typical of wild-type animals." [WB:cab, WB:WBPaper00005863, WB:WBPaper00026717, WB:WBPerson557] subset: phenotype_slim_wb synonym: "Age" BROAD three_letter_name [] synonym: "longevity_abnormal" RELATED [] is_a: WBPhenotype:0000576 ! organism_physiology_abnormal [Term] id: WBPhenotype:0000040 name: one_cell_arrest_early_emb def: "Embryos fail to divide and arrest as one-cell embryos." [WB:cab, WB:cgc5599] synonym: "catastrophic_one_cell_arrest" RELATED [WB:cgc5599] synonym: "Emb" BROAD [] synonym: "Ocs" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000041 name: osmotic_integrity_abnormal is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000042 name: slow_embryonic_development def: "The progression through stages between fertilization to hatching are temporally retarded." [WB:WBPerson712] synonym: "Sle" BROAD three_letter_name [] is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000043 name: general_pace_of_development_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000531 ! organism_development_abnormal is_a: WBPhenotype:0000576 ! organism_physiology_abnormal [Term] id: WBPhenotype:0000044 name: egg_size_abnormal_early_emb def: "Egg is smaller or larger than normal." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000037 ! egg_morphology_abnormal is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000045 name: developmental_delay_postembryonic def: "Postembryonic development is delayed compared with wild type." [WB:cab, WB:WBPaper00025054] is_a: WBPhenotype:0000049 ! postembryonic_development_abnormal [Term] id: WBPhenotype:0000046 name: pace_of_P_lineage_abnormal_early_emb def: "More than five minutes between AB and P1 divisions." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000746 ! cell_division_abnormal is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000047 name: gastrulation_abnormal def: "Any alterations in the process by which the germ layers become positioned in an embryo. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space. " [WB:WBPaper00027251, WB:WBPerson2021] is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000048 name: hatching_abnormal is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000049 name: postembryonic_development_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000531 ! organism_development_abnormal [Term] id: WBPhenotype:0000050 name: embryonic_lethal def: "Animals die during embryonic development, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054] subset: phenotype_slim_wb synonym: "Emb" BROAD three_letter_name [] synonym: "embryonic_death" RELATED [] synonym: "inviable_zygote" RELATED [] is_a: WBPhenotype:0000062 ! lethal is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000051 name: embryonic_terminal_arrest_variable_emb def: "The developmental program does not continue past embryogenesis; stage of arrest is not consistent from animal to animal. " [GO:0009790, WB:WBPaper00004811, WB:WBPaper00024944, WB:WBPerson712] synonym: "Emb" BROAD [] synonym: "Etv" RELATED [] is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000052 name: maternal_effect_lethal_emb def: "Lethality caused by the perturbation of maternal control genes which are transcribed during oogenesis and are required only during embryogenesis. " [WB:WBPaper00001109, WB:WBPerson2021] synonym: "Emb" BROAD [] synonym: "Mel" BROAD three_letter_name [] is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0000053 name: paralyzed_arrested_elongation_two_fold def: "Mutant embryos do not move (wild-type embryos move soon after they reach the one-and-one-half-fold stage of elongation), and elongation in mutants arrests at the two-fold stage. Development in mutants continues (e.g. pharyngeal and cuticle formation is normal), but the myofilament lattice in body wall muscle cells is abnormal. Embryos hatch as inviable larvae." [WB:cab, WB:cgc1894] synonym: "active_elongation_arrest" RELATED [] synonym: "Pat" BROAD three_letter_name [] synonym: "two_fold_arrest" RELATED [] is_a: WBPhenotype:0000050 ! embryonic_lethal is_a: WBPhenotype:0000494 ! two_fold_arrest [Term] id: WBPhenotype:0000054 name: larval_lethal def: "The animal dies at any time between hatching and recovery to adult from the L4 molt." [GO:0002119, WB:WBPerson712] subset: phenotype_slim_wb synonym: "larval_death" RELATED [] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000055 name: early_larval_arrest def: "Larval arrest during the L1 or L2 stages of larval development." [WB:cab] is_a: WBPhenotype:0000059 ! larval_arrest [Term] id: WBPhenotype:0000056 name: late_larval_arrest def: "Larval arrest during the L3 or L4 stages of larval development." [WB:cab] is_a: WBPhenotype:0000059 ! larval_arrest [Term] id: WBPhenotype:0000057 name: early_larval_lethal def: "Animals die during the L1- L2 larval stages of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000054 ! larval_lethal [Term] id: WBPhenotype:0000058 name: late_larval_lethal def: "Animals die during the L3- L4 larval stages of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000054 ! larval_lethal [Term] id: WBPhenotype:0000059 name: larval_arrest def: "The developmental program of the animals halts at any of the four larval stages (L1-L4). As a result, the animals fail to reach adulthood." [WB:WBPaper00002958, WB:WBPerson2021] synonym: "Lva" BROAD three_letter_name [] is_a: WBPhenotype:0000750 ! larval_development_abnormal is_a: WBPhenotype:0001016 ! larval_growth_abnormal [Term] id: WBPhenotype:0000060 name: adult_lethal def: "Early lethality during the adult stage. When applied to large-scale RNAi screens, this phenotype is present in at least 10% of analyzed worms (or at least 30% in the case of rrf-3)." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPaper00006395] subset: phenotype_slim_wb synonym: "Adl" BROAD three_letter_name [WB:WBPaper00004402, WB:WBPaper00005654] synonym: "Let" BROAD [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000061 name: extended_life_span synonym: "Age" BROAD three_letter_name [] synonym: "longevity_increased" RELATED [] is_a: WBPhenotype:0000039 ! life_span_abnormal [Term] id: WBPhenotype:0000062 name: lethal def: "Animals die due to abnormalities in genes with essential metabolic roles at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "Let" BROAD three_letter_name [] is_a: WBPhenotype:0000531 ! organism_development_abnormal [Term] id: WBPhenotype:0000063 name: terminal_arrest_variable synonym: "Var" BROAD three_letter_name [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000064 name: sexually_dimorphic_lethality synonym: "Let" RELATED [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000065 name: X0_lethal def: "XO-bearing individuals die preferentially over XX-bearing animals" [WB:WBPerson363, WB:WBPerson712] subset: phenotype_slim_wb synonym: "Let" BROAD [] synonym: "male specific lethality" RELATED [] is_a: WBPhenotype:0000064 ! sexually_dimorphic_lethality [Term] id: WBPhenotype:0000066 name: XX_lethal def: "XX-bearing individuals die preferentially over XO-bearing animals" [WB:WBPerson363, WB:WBPerson712] subset: phenotype_slim_wb synonym: "hermaphrodite specific lethality" RELATED [] is_a: WBPhenotype:0000064 ! sexually_dimorphic_lethality [Term] id: WBPhenotype:0000067 name: organism_stress_response_abnormal is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_abnormal [Term] id: WBPhenotype:0000068 name: oxidative_stress_response_abnormal is_a: WBPhenotype:0000142 ! cell_stress_response_abnormal [Term] id: WBPhenotype:0000069 name: progeny_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000531 ! organism_development_abnormal [Term] id: WBPhenotype:0000070 name: male_tail_morphology_abnormal def: "Animals exhibit deviations in the structure or organization of the somatic reproductive components of the posterior segment of the male from that observed in normal males. This region of the male includes the terminal canals of the reproductive tract, the digestive tract, and spicule channels along with the male specific sensilla (ray, post-cloacal, hook and spicule) and extends to the tip of the acellular fan." [WB:WBPaper00027278, WB:WBPerson712] synonym: "Mab" BROAD three_letter_name [] is_a: WBPhenotype:0000073 ! tail_morphology_abnormal is_a: WBPhenotype:0001024 ! male_morphology_abnormal [Term] id: WBPhenotype:0000071 name: head_morphology_abnormal is_a: WBPhenotype:0000582 ! organism_segment_morphology_abnormal [Term] id: WBPhenotype:0000072 name: body_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000582 ! organism_segment_morphology_abnormal [Term] id: WBPhenotype:0000073 name: tail_morphology_abnormal is_a: WBPhenotype:0000582 ! organism_segment_morphology_abnormal [Term] id: WBPhenotype:0000074 name: genetic_pathway_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000576 ! organism_physiology_abnormal [Term] id: WBPhenotype:0000075 name: cuticle_attachment_abnormal is_a: WBPhenotype:0000201 ! cuticle_development_abnormal [Term] id: WBPhenotype:0000076 name: epithelial_attachment_abnormal synonym: "hypodermal_attachment_abnormal" RELATED [] is_a: WBPhenotype:0000608 ! epithelial_system_physiology_abnormal [Term] id: WBPhenotype:0000077 name: cuticle_shedding_abnormal is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000078 name: seam_cells_stacked is_a: WBPhenotype:0000703 ! epithelial_morphology_abnormal [Term] id: WBPhenotype:0000079 name: branched_adult_alae is_a: WBPhenotype:0001412 ! alae_morphology_abnormal [Term] id: WBPhenotype:0000080 name: no_anterior_pharynx def: "Embryos fail to generate the AB blastomere- derived pharyngeal cells, which constitute the anterior portion of the pharynx." [WB:WBPaper00001008, WB:WBPerson2021] synonym: "Aph" BROAD three_letter_name [] is_a: WBPhenotype:0000115 ! anterior_pharynx_abnormal is_a: WBPhenotype:0001646 ! no_pharynx [Term] id: WBPhenotype:0000081 name: L1_arrest def: "The developmental program of the animals does not continue past the first larval stage (L1)." [WB:WBPaper00003179, WB:WBPerson2021] is_a: WBPhenotype:0000055 ! early_larval_arrest is_a: WBPhenotype:0000751 ! L1_larval_development_abnormal [Term] id: WBPhenotype:0000082 name: L2_arrest def: "The developmental program of the animals does not continue past the second larval stage (L2). " [WB:WBPaper00003179, WB:WBPerson2021] is_a: WBPhenotype:0000055 ! early_larval_arrest is_a: WBPhenotype:0000752 ! L2_larval_development_abnormal is_a: WBPhenotype:0001019 ! mid_larval_arrest [Term] id: WBPhenotype:0000083 name: L3_arrest def: "The developmental program of the animals does not continue past the third larval stage (L3)." [WB:WBPaper00004813, WB:WBPerson2021] is_a: WBPhenotype:0000056 ! late_larval_arrest is_a: WBPhenotype:0000753 ! L3_larval_development_abnormal is_a: WBPhenotype:0001019 ! mid_larval_arrest [Term] id: WBPhenotype:0000084 name: L4_arrest def: "The developmental program of the animals does not continue past the fourth larval stage (L4)." [WB:WBPaper00003179, WB:WBPerson2021] is_a: WBPhenotype:0000056 ! late_larval_arrest is_a: WBPhenotype:0000754 ! L4_larval_development_abnormal [Term] id: WBPhenotype:0000085 name: swollen_intestine is_a: WBPhenotype:0000710 ! intestinal_morphology_abnormal [Term] id: WBPhenotype:0000086 name: shrunken_intestine is_a: WBPhenotype:0000710 ! intestinal_morphology_abnormal [Term] id: WBPhenotype:0000087 name: body_wall_cell_development_abnormal synonym: "body_wall_muscle_cell_development_abnormal" RELATED [] is_a: WBPhenotype:0000815 ! muscle_cell_development_abnormal [Term] id: WBPhenotype:0000088 name: body_muscle_displaced synonym: "body_wall_muscle_displaced" RELATED [] is_a: WBPhenotype:0000861 ! body_wall_muscle_development_abnormal [Term] id: WBPhenotype:0000089 name: alpha_amanitin_resistant is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000090 name: epidermis_cuticle_detached synonym: "hypodermis_detached_from_cuticle" RELATED [] is_a: WBPhenotype:0000075 ! cuticle_attachment_abnormal is_a: WBPhenotype:0000076 ! epithelial_attachment_abnormal [Term] id: WBPhenotype:0000091 name: epidermis_muscle_detached synonym: "hypodermis_detached_from_muscle" RELATED [] is_a: WBPhenotype:0000076 ! epithelial_attachment_abnormal is_a: WBPhenotype:0000474 ! muscle_attachment_abnormal [Term] id: WBPhenotype:0000092 name: intestinal_cell_proliferation_abnormal is_a: WBPhenotype:0000705 ! intestinal_cell_development_abnormal [Term] id: WBPhenotype:0000093 name: lineage_abnormal def: "The descendants of a particular precursor cell exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "Lin" BROAD three_letter_name [] is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000094 name: anus_development_abnormal relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_abnormal [Term] id: WBPhenotype:0000095 name: M_lineage_abnormal def: "The descendants of the M precursor cell exhibit altered developmental programs compared to their counterparts in normal animals. " [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000096 name: cloacal_development_abnormal relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_abnormal [Term] id: WBPhenotype:0000097 name: AB_lineage_abnormal def: "The descendants of the AB blastomere exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPaper00001584, WB:WBPerson2021] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000098 name: pharyngeal_intestinal_valve_development_abnormal relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_abnormal [Term] id: WBPhenotype:0000099 name: P_lineages_abnormal def: "The descendants of any of the P precursor cells (P1-P12) exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000100 name: cell_UV_response_abnormal is_a: WBPhenotype:0000142 ! cell_stress_response_abnormal [Term] id: WBPhenotype:0000101 name: UV_induced_apoptosis_increased is_a: WBPhenotype:0000100 ! cell_UV_response_abnormal is_a: WBPhenotype:0000183 ! apoptosis_increased [Term] id: WBPhenotype:0000102 name: presynaptic_vesicle_cluster_abnormal def: "Animals display deviations in the organization, accumulation or distribution of transmitter-containing membrane-bound organelles (synaptic vesicles) that surround the electron-dense membrane specialization of the presynaptic region of the synapse,compared to that observed in normal animals. " [WB:WBPaper00027305] synonym: "synaptic_vesicle_cluster_abnormal" RELATED [] relationship: part_of WBPhenotype:0001321 ! presynaptic_region_morphology_abnormal [Term] id: WBPhenotype:0000103 name: gut_granule_development_abnormal relationship: part_of WBPhenotype:0000705 ! intestinal_cell_development_abnormal [Term] id: WBPhenotype:0000104 name: cell_polarity_abnormal def: "Contents or structures of a cell are no longer restricted/localized to their typical positions within the cell." [WB:WBPaper00031356, WB:WBPerson2021, WB:WBPerson712] subset: phenotype_slim_wb is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000105 name: oocyte_meiotic_maturation_abnormal def: "Any alteration in the progression of a developing oocyte, from diakinesis to metaphase (meiosis I), in response to a signal. Meiotic maturation is accompanied by nuclear envelope breakdown (germinal vesicle breakdown), cytoskeletal rearrangement and meiotic spindle assembly." [GO:0001556, WB:WBPaper00026997, WB:WBPerson2021] synonym: "Oma" BROAD three_letter_name [] is_a: WBPhenotype:0000313 ! meiotic_progression_during_oogenesis_abnormal [Term] id: WBPhenotype:0000106 name: inhibition_of_oocyte_maturation_abnormal def: "Any aberrancy in the processes that negatively regulate the meiotic progression of oocytes (exit from diakinesis) in the absence of a signal." [WB:WBPaper00003371, WB:WBPaper00026997, WB:WBPerson2021] is_a: WBPhenotype:0000105 ! oocyte_meiotic_maturation_abnormal [Term] id: WBPhenotype:0000107 name: inhibition_of_ovulation_abnormal is_a: WBPhenotype:0000666 ! ovulation_abnormal [Term] id: WBPhenotype:0000108 name: severe_dumpy is_obsolete: true [Term] id: WBPhenotype:0000109 name: moderate_dumpy is_obsolete: true [Term] id: WBPhenotype:0000110 name: slightly_dumpy is_obsolete: true [Term] id: WBPhenotype:0000111 name: pattern_of_gene_expression_abnormal is_a: WBPhenotype:0000717 ! gene_expression_abnormal [Term] id: WBPhenotype:0000112 name: protein_expression_abnormal is_a: WBPhenotype:0000717 ! gene_expression_abnormal [Term] id: WBPhenotype:0000113 name: RNA_expression_abnormal is_a: WBPhenotype:0000717 ! gene_expression_abnormal [Term] id: WBPhenotype:0000114 name: mRNA_expression_abnormal is_a: WBPhenotype:0000113 ! RNA_expression_abnormal [Term] id: WBPhenotype:0000115 name: anterior_pharynx_abnormal is_a: WBPhenotype:0000707 ! pharyngeal_development_abnormal [Term] id: WBPhenotype:0000116 name: mid_larval_lethal def: "Animals die during the L2- L3 larval stages of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD three_letter_name [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000054 ! larval_lethal [Term] id: WBPhenotype:0000117 name: L1_lethal def: "Animals die at the L1 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000057 ! early_larval_lethal [Term] id: WBPhenotype:0000118 name: L2_lethal def: "L2_lethal: Animals die at the L2 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD three_letter_name [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000057 ! early_larval_lethal is_a: WBPhenotype:0000116 ! mid_larval_lethal [Term] id: WBPhenotype:0000119 name: protein_expression_increased is_a: WBPhenotype:0001400 ! level_of_protein_expression_abnormal [Term] id: WBPhenotype:0000120 name: protein_expression_reduced def: "Any change that results in lower than normal levels of protein expression." [WB:kmva] is_a: WBPhenotype:0001400 ! level_of_protein_expression_abnormal [Term] id: WBPhenotype:0000121 name: translation_abnormal is_a: WBPhenotype:0000112 ! protein_expression_abnormal [Term] id: WBPhenotype:0000122 name: post_translational_processing_abnormal is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0000123 name: enzyme_expression_level_reduced is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0000124 name: enzyme_activity_reduced is_a: WBPhenotype:0000727 ! enzyme_activity_abnormal [Term] id: WBPhenotype:0000125 name: enzyme_activity_increased is_a: WBPhenotype:0000727 ! enzyme_activity_abnormal [Term] id: WBPhenotype:0000126 name: general_pace_of_development_abnormal_early_emb def: "More than 30 minutes from PN meeting to furrow initiation in AB." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000043 ! general_pace_of_development_abnormal is_a: WBPhenotype:0001186 ! embryo_delayed_at_pronuclear_contact_early_emb [Term] id: WBPhenotype:0000127 name: dauer_recovery_abnormal def: "Characteristic exit from the dauer stage is altered." [WB:cab] is_a: WBPhenotype:0000159 ! dauer_arrest_abnormal [Term] id: WBPhenotype:0000128 name: temperature_induced_dauer_formation_increased def: "Dauer larvae are more likely to form at high temperature, even in the presence of food." [WB:cgc424] synonym: "Hid" BROAD three_letter_name [] is_a: WBPhenotype:0000639 ! temperature_induced_dauer_formation_abnormal [Term] id: WBPhenotype:0000129 name: temperature_induced_dauer_formation_defective is_a: WBPhenotype:0000013 ! dauer_defective is_a: WBPhenotype:0000639 ! temperature_induced_dauer_formation_abnormal [Term] id: WBPhenotype:0000130 name: pheromone_induced_dauer_formation_enhance is_a: WBPhenotype:0000132 ! pheromone_induced_dauer_formation_abnormal [Term] id: WBPhenotype:0000131 name: pheromone_induced_dauer_formation_defective is_a: WBPhenotype:0000013 ! dauer_defective is_a: WBPhenotype:0000132 ! pheromone_induced_dauer_formation_abnormal [Term] id: WBPhenotype:0000132 name: pheromone_induced_dauer_formation_abnormal is_a: WBPhenotype:0001539 ! dauer_induction_abnormal [Term] id: WBPhenotype:0000133 name: expression_lipogenic_enzyme_reduced is_a: WBPhenotype:0000123 ! enzyme_expression_level_reduced [Term] id: WBPhenotype:0000134 name: gene_expression_level_reduced is_a: WBPhenotype:0000717 ! gene_expression_abnormal [Term] id: WBPhenotype:0000135 name: gene_expression_level_high is_a: WBPhenotype:0000717 ! gene_expression_abnormal [Term] id: WBPhenotype:0000136 name: mRNA_levels_increased is_a: WBPhenotype:0000114 ! mRNA_expression_abnormal [Term] id: WBPhenotype:0000137 name: mRNA_levels_reduced is_a: WBPhenotype:0000114 ! mRNA_expression_abnormal [Term] id: WBPhenotype:0000138 name: lipid_composition_abnormal synonym: "fat_composition_abnormal" RELATED [] synonym: "fatty_acid_composition_abnormal" RELATED [] is_a: WBPhenotype:0000725 ! lipid_metabolism_abnormal [Term] id: WBPhenotype:0000139 name: stress_induced_lethality_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000140 name: stress_induced_arrest_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000141 name: stress_induced_lethality_increased is_a: WBPhenotype:0000139 ! stress_induced_lethality_abnormal [Term] id: WBPhenotype:0000142 name: cell_stress_response_abnormal is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000143 name: organism_UV_response_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000144 name: pathogen_induced_cell_death_increased is_a: WBPhenotype:0000142 ! cell_stress_response_abnormal is_a: WBPhenotype:0001269 ! pathogen_induced_cell_death_abnormal [Term] id: WBPhenotype:0000145 name: fertility_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000613 ! reproductive_system_physiology_abnormal [Term] id: WBPhenotype:0000146 name: organism_temperature_response_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000147 name: organism_starvation_response_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000148 name: starvation_induced_dauer_formation_abnormal is_a: WBPhenotype:0000147 ! organism_starvation_response_abnormal is_a: WBPhenotype:0001539 ! dauer_induction_abnormal [Term] id: WBPhenotype:0000149 name: starvation_induced_dauer_formation_increased is_a: WBPhenotype:0000148 ! starvation_induced_dauer_formation_abnormal [Term] id: WBPhenotype:0000150 name: starvation_induced_dauer_formation_defective is_a: WBPhenotype:0000013 ! dauer_defective is_a: WBPhenotype:0000148 ! starvation_induced_dauer_formation_abnormal [Term] id: WBPhenotype:0000151 name: anterior_pharynx_extra_cells def: "Embryos generate an excess number of AB blastomere-derived pharyngeal cells. This hyperinduction of anterior pharyngeal tissue is associated with defects in fate specification of the ABp blastomere." [WB:WBPaper00001930, WB:WBPerson2021] synonym: "Apx " BROAD three_letter_name [] is_a: WBPhenotype:0000115 ! anterior_pharynx_abnormal [Term] id: WBPhenotype:0000152 name: no_cleavage_furrow_first_division_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001129 ! cleavage_furrow_abnormal_early_emb [Term] id: WBPhenotype:0000153 name: body_wall_contraction_abnormal synonym: "body_wall_muscle_contraction_abnormal" RELATED [] relationship: part_of WBPhenotype:0000596 ! body_behavior_abnormal [Term] id: WBPhenotype:0000154 name: reduced_brood_size def: "The characteristic number of offspring produced by a hermaphrodite is lower compared to that of normal animals." [WB:WBPerson557] is_a: WBPhenotype:0000673 ! brood_size_abnormal [Term] id: WBPhenotype:0000155 name: cell_polarity_reversed def: "Contents or structures of the cell are oriented on the opposite side of the cell; during cell division, the fate pattern of descendants is flipped." [WB:WBPaper00031356, WB:WBPerson2021, WB:WBPerson712] is_a: WBPhenotype:0000104 ! cell_polarity_abnormal [Term] id: WBPhenotype:0000156 name: body_wall_contraction_interval_abnormal synonym: "body_wall_muscle_contraction_interval_abnormal" RELATED [] is_a: WBPhenotype:0000210 ! defecation_contraction_abnormal [Term] id: WBPhenotype:0000157 name: posterior_body_wall_contraction_abnormal def: "Animals exhibit alterations in the sustained posterior body muscle contractions that precede the remaining contractions of the defecation cycle." [WB:WBPaper00031426, WB:WBPerson712] synonym: "pBoc" BROAD three_letter_name [] synonym: "posterior_body_contraction_abnormal" RELATED [] synonym: "posterior_body_wall_contraction_defective" RELATED [] is_a: WBPhenotype:0000210 ! defecation_contraction_abnormal [Term] id: WBPhenotype:0000158 name: posterior_body_wall_shortened_interval is_a: WBPhenotype:0000157 ! posterior_body_wall_contraction_abnormal [Term] id: WBPhenotype:0000159 name: dauer_arrest_abnormal is_a: WBPhenotype:0000576 ! organism_physiology_abnormal [Term] id: WBPhenotype:0000160 name: cleavage_furrow_not_discrete_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001129 ! cleavage_furrow_abnormal_early_emb [Term] id: WBPhenotype:0000161 name: nuclear_rotation_abnormal is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000162 name: pale_larva synonym: "translucent" RELATED [] is_a: WBPhenotype:0000890 ! larval_pigmentation_abnormal is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000163 name: clear_larva synonym: "Clr" BROAD three_letter_name [] synonym: "transparent" RELATED [] is_a: WBPhenotype:0000890 ! larval_pigmentation_abnormal is_a: WBPhenotype:0001010 ! clear [Term] id: WBPhenotype:0000164 name: thin def: "Animals exhibit a reduced girth compared to a normal animal of the same developmental stage." [WB:WBPerson712] synonym: "slim" RELATED [] is_a: WBPhenotype:0000231 ! body_size_abnormal [Term] id: WBPhenotype:0000165 name: cell_fusion_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000166 name: seam_cell_fusion_abnormal is_a: WBPhenotype:0000165 ! cell_fusion_abnormal [Term] id: WBPhenotype:0000167 name: precocious_seam_cell_fusion is_a: WBPhenotype:0000166 ! seam_cell_fusion_abnormal is_a: WBPhenotype:0001433 ! precocious_cell_fusion [Term] id: WBPhenotype:0000168 name: alae_secretion_abnormal is_a: WBPhenotype:0000258 ! cell_secretion_abnormal [Term] id: WBPhenotype:0000169 name: early_exit_cell_cycle is_a: WBPhenotype:0000740 ! cell_cycle_abnormal [Term] id: WBPhenotype:0000170 name: precocious_alae def: "Formation of the adult lateral alae occurs early in development; in wild type, adult lateral alae are generated during late L4 stage." [pmid:3428573, WB:cab] is_a: WBPhenotype:0000168 ! alae_secretion_abnormal [Term] id: WBPhenotype:0000171 name: cell_proliferation_abnormal def: "Any aberrancy in the processes that govern expansion of cell populations." [GO:0008283, WB:WBPerson2021] subset: phenotype_slim_wb is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000172 name: cell_proliferation_increased def: "The processes governing the expansion of cell populations are altered, such that cell populations are increased." [WB:WBPerson2021] is_a: WBPhenotype:0000171 ! cell_proliferation_abnormal [Term] id: WBPhenotype:0000173 name: cell_proliferation_reduced def: "The processes governing the expansion of cell populations are altered, such that cell populations are decreased." [WB:WBPerson2021] is_a: WBPhenotype:0000171 ! cell_proliferation_abnormal [Term] id: WBPhenotype:0000174 name: basal_lamina_development_abnormal relationship: part_of WBPhenotype:0000619 ! epithelial_system_development_abnormal [Term] id: WBPhenotype:0000175 name: hypercontracted is_a: WBPhenotype:0000001 ! body_posture_abnormal [Term] id: WBPhenotype:0000176 name: satiety_behavior_abnormal is_a: WBPhenotype:0000659 ! feeding_behavior_abnormal [Term] id: WBPhenotype:0000177 name: acetylcholinesterase_reduced is_a: WBPhenotype:0000124 ! enzyme_activity_reduced [Term] id: WBPhenotype:0000178 name: cell_degeneration is_a: WBPhenotype:0000729 ! cell_death_abnormal [Term] id: WBPhenotype:0000179 name: neuron_degeneration is_a: WBPhenotype:0000178 ! cell_degeneration [Term] id: WBPhenotype:0000180 name: axon_morphology_abnormal def: "Animals display deviations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in normal animals." [GO:0030424, WB:WBPaper00005236, WB:WBPerson712] relationship: part_of WBPhenotype:0001398 ! neurite_morphology_abnormal [Term] id: WBPhenotype:0000181 name: axon_trajectory_abnormal def: "Animals display deviations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in normal animals." [WB:WBPaper00001105, WB:WBPerson712] is_a: WBPhenotype:0000180 ! axon_morphology_abnormal [Term] id: WBPhenotype:0000182 name: apoptosis_reduced def: "Any perturbation that causes a decrease in the frequency of cell death by apoptosis." [GO:0043065, WB:WBPerson2021] is_a: WBPhenotype:0000730 ! apoptosis_abnormal [Term] id: WBPhenotype:0000183 name: apoptosis_increased def: "Any perturbation that causes an elevation in the frequency of cell death by apoptosis." [GO:0043066, WB:WBPerson2021] is_a: WBPhenotype:0000730 ! apoptosis_abnormal [Term] id: WBPhenotype:0000184 name: apoptosis_fails_to_occur is_a: WBPhenotype:0000182 ! apoptosis_reduced [Term] id: WBPhenotype:0000185 name: apoptosis_protracted is_a: WBPhenotype:0000730 ! apoptosis_abnormal [Term] id: WBPhenotype:0000186 name: oogenesis_abnormal alt_id: WBPhenotype:0000896 def: "Any aberrancy in the processes that influence the generation and maturation of oocytes." [GO:0048477, WB:WBPerson2021] synonym: "oocyte_development_abnormal" RELATED [] synonym: "oocyte_germ_cell_differentiation_abnormal" EXACT [] is_a: WBPhenotype:0000894 ! germ_cell_differentiation_abnormal [Term] id: WBPhenotype:0000187 name: egg_round is_a: WBPhenotype:0000037 ! egg_morphology_abnormal [Term] id: WBPhenotype:0000188 name: gonad_arm_morphology_abnormal is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_abnormal [Term] id: WBPhenotype:0000189 name: hypodermis_disorganized def: "Hypodermal cells fail to be organized into distinct dorsal, lateral and ventral rows or are distorted to the periphery of the embryo thereby failing to cover the entire body. The shape of hypodermal cells is often distorted as well. " [WB:WBPaper00027006, WB:WBPerson2021] is_a: WBPhenotype:0000703 ! epithelial_morphology_abnormal [Term] id: WBPhenotype:0000190 name: no_dauer_recovery is_a: WBPhenotype:0000127 ! dauer_recovery_abnormal [Term] id: WBPhenotype:0000191 name: organism_crowding_response_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000192 name: constitutive_enzyme_activity is_a: WBPhenotype:0000125 ! enzyme_activity_increased [Term] id: WBPhenotype:0000193 name: dominant_negative_enzyme is_a: WBPhenotype:0000727 ! enzyme_activity_abnormal [Term] id: WBPhenotype:0000194 name: first_polar_body_position_abnormal is_a: WBPhenotype:0000775 ! meiosis_abnormal [Term] id: WBPhenotype:0000195 name: distal_tip_cell_migration_abnormal def: "Any alteration in the symmetrical U-shaped migration pattern of the two distal tip cells (DTCs) in a developing hermaphrodite. DTCs (located on the anterior and posterior ends of the gonad primordium) generate the rotational symmetry of the gonad arm. " [WB:WBPaper00003598, WB:WBPerson2021] synonym: "DTC_migration_abnormal" RELATED [] is_a: WBPhenotype:0000594 ! cell_migration_abnormal [Term] id: WBPhenotype:0000196 name: distal_tip_cell_morphology_abnormal def: "The morphological appearance of distal tip cells is abnormal compared to wild type." [WB:cab] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000197 name: cell_induction_abnormal def: "Any alteration in a cell's ability to influence the fate of another cell (often of different developmental potential or ancestry via short range signaling)." [GO:0031128, WB:WBPerson2021] is_a: WBPhenotype:0000216 ! cell_fate_specification_abnormal [Term] id: WBPhenotype:0000199 name: male_tail_sensory_ray_development_abnormal relationship: part_of WBPhenotype:0001008 ! male_nervous_system_development_abnormal [Term] id: WBPhenotype:0000200 name: pericellular_component_development_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000518 ! development_abnormal [Term] id: WBPhenotype:0000201 name: cuticle_development_abnormal is_a: WBPhenotype:0000200 ! pericellular_component_development_abnormal [Term] id: WBPhenotype:0000202 name: alae_abnormal is_a: WBPhenotype:0000201 ! cuticle_development_abnormal [Term] id: WBPhenotype:0000203 name: odorant_adaptation_abnormal def: "Mutant animals do not exhibit characteristic desensitization to a volatile organic chemo-attractive signal in a time-concentration dependent and reversible manner." [WB:WBPerson2021] is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_abnormal [Term] id: WBPhenotype:0000204 name: anterior_body_contraction_defective def: "Defects in the anterior body muscle contraction (aBoc) step of the defecation cycle. Under normal conditions, anterior body wall muscles contract and pressurize the intestinal contents during the aBoc step. " [WB:WBPerson2021] synonym: "aBoc" BROAD three_letter_name [] is_a: WBPhenotype:0001476 ! anterior_body_contraction_abnormal [Term] id: WBPhenotype:0000205 name: expulsion_abnormal synonym: "Exp" RELATED [] is_a: WBPhenotype:0000210 ! defecation_contraction_abnormal [Term] id: WBPhenotype:0000206 name: autosomal_nondisjunction_meiosis is_a: WBPhenotype:0001174 ! chromosome_disjunction_abnormal [Term] id: WBPhenotype:0000207 name: defecation_cycle_abnormal is_a: WBPhenotype:0000650 ! defecation_abnormal [Term] id: WBPhenotype:0000208 name: long_defecation_cycle is_a: WBPhenotype:0000207 ! defecation_cycle_abnormal [Term] id: WBPhenotype:0000209 name: short_defecation_cycle is_a: WBPhenotype:0000207 ! defecation_cycle_abnormal [Term] id: WBPhenotype:0000210 name: defecation_contraction_abnormal is_a: WBPhenotype:0000650 ! defecation_abnormal [Term] id: WBPhenotype:0000211 name: defecation_contraction_asynchronous synonym: "defecation_contraction_mistimed" RELATED [] is_a: WBPhenotype:0000210 ! defecation_contraction_abnormal [Term] id: WBPhenotype:0000212 name: body_constriction is_a: WBPhenotype:0000072 ! body_morphology_abnormal [Term] id: WBPhenotype:0000213 name: zygotic_development_abnormal is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000214 name: alpha_amanitin_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000215 name: no_germ_line def: "Animals lack all germline progenitor cells, thereby resulting in the complete absence of a germline." [WB:WBPaper00001477, WB:WBPerson2021] synonym: "no_germline" EXACT [] is_a: WBPhenotype:0000812 ! germ_cell_development_abnormal [Term] id: WBPhenotype:0000216 name: cell_fate_specification_abnormal def: "Any abnormality in the processes that govern acquisition of particular cell fates." [WB:kmva] subset: phenotype_slim_wb is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000217 name: prolonged_pharyngeal_contraction is_a: WBPhenotype:0000980 ! pharyngeal_contraction_abnormal [Term] id: WBPhenotype:0000218 name: vulval_cell_induction_increased def: "An excess number of vulval precursor cells adopt 1 or 2 vulval fates (usually due to perturbations that increase the inductive signal). " [WB:WBPerson2021] synonym: "Hin" BROAD three_letter_name [] synonym: "overinduced" NARROW [] is_a: WBPhenotype:0001272 ! vulval_cell_induction_abnormal [Term] id: WBPhenotype:0000219 name: vulval_cell_induction_reduced def: "An excess number of vulval precursor cells adopt a 3 nonvulval fate (usually due to perturbations that decrease the inductive signal)." [WB:WBPerson2021] synonym: "underinduced" NARROW [] is_a: WBPhenotype:0001272 ! vulval_cell_induction_abnormal [Term] id: WBPhenotype:0000220 name: vulva_cell_fate_specification_abnormal def: "Any aberrancy in the processes that govern acquisition of vulval cell fates." [WB:WBPerson2021] is_a: WBPhenotype:0000216 ! cell_fate_specification_abnormal is_a: WBPhenotype:0000699 ! vulva_development_abnormal [Term] id: WBPhenotype:0000221 name: neurotransmitter_metabolism_abnormal is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0000222 name: serotonin_metabolism_abnormal is_a: WBPhenotype:0000221 ! neurotransmitter_metabolism_abnormal [Term] id: WBPhenotype:0000223 name: acetylcholine_metabolism_abnormal is_a: WBPhenotype:0000221 ! neurotransmitter_metabolism_abnormal [Term] id: WBPhenotype:0000224 name: serotonin_deficient is_a: WBPhenotype:0000222 ! serotonin_metabolism_abnormal [Term] id: WBPhenotype:0000225 name: serotonin_synthesis_defective is_a: WBPhenotype:0000222 ! serotonin_metabolism_abnormal [Term] id: WBPhenotype:0000226 name: serotonin_catabolism_defective is_a: WBPhenotype:0000222 ! serotonin_metabolism_abnormal [Term] id: WBPhenotype:0000227 name: male_turning_abnormal def: "The inability of a male to properly turn, via a sharp ventral arch of the tail, as he approaches either the hermaphrodite head or tail during mating." [WB:WBPaper00000392, WB:WBPaper00002109] is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_abnormal [Term] id: WBPhenotype:0000228 name: spontaneous_mutation_rate_increased def: "Animals accumulate a greater number of genetic lesions than normal in the absence of an externally controlled mutagen, often measured by observing the number of reversion events of a known mutant gene function over a couple generations." [WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000229 name: small alt_id: WBPhenotype:0000271 def: "Animals are shorter and thinner than wild-type animals." [WB:cab, WB:cgc31] synonym: "body_size_reduced" EXACT [] synonym: "Sma" RELATED [] is_a: WBPhenotype:0000231 ! body_size_abnormal [Term] id: WBPhenotype:0000230 name: tail_withered is_a: WBPhenotype:0000073 ! tail_morphology_abnormal [Term] id: WBPhenotype:0000231 name: body_size_abnormal def: "Animals exhibit deviations in the physical dimensions of its body compared to normal animals of the same developmental stage." [PATO:0000117, WB:WBPerson712] is_a: WBPhenotype:0000072 ! body_morphology_abnormal [Term] id: WBPhenotype:0000232 name: CAN_cell_migration_abnormal def: "Any variation in the normal posterior movement of the CAN neurons from their birthplace in the head to positions near the middle of the embryo." [WB:WBPaper00002795, WB:WBPerson2021] is_a: WBPhenotype:0001520 ! abnormal_posterior_neuron_migration [Term] id: WBPhenotype:0000233 name: dopamine_metabolism_abnormal is_a: WBPhenotype:0000221 ! neurotransmitter_metabolism_abnormal is_a: WBPhenotype:0001518 ! biogenic_amine_physiology_abnormal [Term] id: WBPhenotype:0000234 name: dopamine_deficient is_a: WBPhenotype:0000233 ! dopamine_metabolism_abnormal [Term] id: WBPhenotype:0000235 name: dopamine_synthesis_defective is_a: WBPhenotype:0000233 ! dopamine_metabolism_abnormal [Term] id: WBPhenotype:0000236 name: dopamine_catabolism_defective is_a: WBPhenotype:0000233 ! dopamine_metabolism_abnormal [Term] id: WBPhenotype:0000237 name: foraging_hyperactive def: "Animals extend intensity of roaming and or dwelling activity, which may include an increase in nose-lifts/minute." [WB:WBPaper00031455, WB:WBPaper00031570, WB:WBPerson712] is_a: WBPhenotype:0000662 ! foraging_behavior_abnormal [Term] id: WBPhenotype:0000238 name: foraging_reduced def: "Animals decrease intensity or rate of roaming and or dwelling activity." [WB:WBPaper00031455, XX:WBPerson712] is_a: WBPhenotype:0000662 ! foraging_behavior_abnormal [Term] id: WBPhenotype:0000239 name: vulval_cell_lineage_abnormal def: "The descendants of a vulval precursor cell (P3.p-P8.p) exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPaper00005610, WB:WBPerson2021] synonym: "VPC_lineage_abnormal" RELATED [] is_a: WBPhenotype:0000099 ! P_lineages_abnormal [Term] id: WBPhenotype:0000240 name: blast_cell_proliferation_reduced is_a: WBPhenotype:0000173 ! cell_proliferation_reduced [Term] id: WBPhenotype:0000241 name: accumulated_cell_corpses is_a: WBPhenotype:0000590 ! cell_corpse_number_abnormal [Term] id: WBPhenotype:0000242 name: body_elongation_defective def: "The epidermal cells of the embryo fail to elongate along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm. " [WB:WBPerson2021] is_a: WBPhenotype:0001478 ! body_elongation_abnormal [Term] id: WBPhenotype:0000243 name: engulfment_failure_by_killer is_a: WBPhenotype:0000885 ! engulfment_abnormal [Term] id: WBPhenotype:0000244 name: apoptotic_arrest synonym: "apoptosis_block" RELATED [] is_a: WBPhenotype:0000730 ! apoptosis_abnormal [Term] id: WBPhenotype:0000245 name: SM_migration_abnormal def: "Any alteration in the normal anterior movement of the larval sex myoblasts to the precise center of the developing hermaphrodite gonad." [WB:WBPaper00003627, WB:WBPerson2021] is_a: WBPhenotype:0001230 ! abnormal_anterior_cell_migration [Term] id: WBPhenotype:0000246 name: defecation_cycle_variable_length is_a: WBPhenotype:0000207 ! defecation_cycle_abnormal [Term] id: WBPhenotype:0000247 name: sodium_chemotaxis_defective def: "Failure to move towards sodium." [WB:cab, WB:cgc387] synonym: "Na_chemotaxis_defective" RELATED [] synonym: "sodium acetate chemotaxis defective" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001440 ! cation_positive_chemotaxis_defective [Term] id: WBPhenotype:0000248 name: sensory_neuroanatomy_abnormal is_obsolete: true [Term] id: WBPhenotype:0000249 name: osmotic_avoidance_defective def: "Failure to execute the characteristic avoidance response to solutions of high osmotic strength." [WB:cab, WB:WBPerson2021] is_a: WBPhenotype:0000663 ! osmotic_avoidance_abnormal [Term] id: WBPhenotype:0000250 name: octopamine_metabolism_abnormal is_a: WBPhenotype:0000221 ! neurotransmitter_metabolism_abnormal is_a: WBPhenotype:0001518 ! biogenic_amine_physiology_abnormal [Term] id: WBPhenotype:0000251 name: octopamine_deficient is_a: WBPhenotype:0000250 ! octopamine_metabolism_abnormal [Term] id: WBPhenotype:0000252 name: caffeine_resistant is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000253 name: movement_erratic synonym: "movement_irregular" RELATED [] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000254 name: chloride_chemotaxis_defective def: "Failure to move towards chloride." [WB:cab, WB:cgc387] synonym: "Cl_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001439 ! anion_positive_chemotaxis_defective is_a: WBPhenotype:0001458 ! chloride_chemotaxis_abnormal [Term] id: WBPhenotype:0000255 name: amphid_phasmid_morphology_abnormal def: "Animals exhibit abnormalities in the quantity, structure or organization of the components of the neuronal cells of the amphid and phasmid sensilla from that observed in normal animals. These neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. " [WB:WBbt\:0005394, WB:WBbt\:0006753, WB:WBPaper00000938] synonym: "dye_filling_defect" RELATED [] synonym: "Dyf" BROAD three_letter_name [] is_a: WBPhenotype:0001527 ! amphid_phasmid_sensillum_morphology_abnormal [Term] id: WBPhenotype:0000256 name: amphid_morphology_abnormal def: "Animals exhibit abnormalities in the quantity, structure or organization of the components of the neuronal cells of the amphid sensillum, from that observed in normal animals. These neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBbt\:0005394, WB:WBPaper00000938] is_a: WBPhenotype:0000255 ! amphid_phasmid_morphology_abnormal [Term] id: WBPhenotype:0000257 name: phasmid_morphology_abnormal def: "Animals exhibit abnormalities in the quantity, structure or organization of the components of the neuronal cells of the phasmid sensillum, from that observed in normal animals. These neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO. " [WB:WBbt\:0006753, WB:WBPaper00000938] is_a: WBPhenotype:0000255 ! amphid_phasmid_morphology_abnormal [Term] id: WBPhenotype:0000258 name: cell_secretion_abnormal alt_id: WBPhenotype:0000723 subset: phenotype_slim_wb synonym: "cellular_secretion_abnormal" EXACT [] is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000259 name: sheath_cell_secretion_abnormal is_a: WBPhenotype:0000258 ! cell_secretion_abnormal [Term] id: WBPhenotype:0000260 name: sheath_cell_secretion_failure is_a: WBPhenotype:0000259 ! sheath_cell_secretion_abnormal [Term] id: WBPhenotype:0000261 name: amphid_sheath_secretion_failure is_a: WBPhenotype:0000260 ! sheath_cell_secretion_failure [Term] id: WBPhenotype:0000262 name: axoneme_morphology_abnormal def: "Animals exhibit abnormalities in the structure or composition of the microtubule-based fibrillar bundle (axoneme) that makes up the core of the middle part of the cilium (in a pattern of nine doublet microtubules attached to the membrane and a variable number of smaller singlet microtubules occupying the center). In normal animals the axoneme microtubules are arranged in a pattern of nine doublets attached to the membrane with seven smaller singlet microtubules occupying the center." [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000615 ! cilia_morphology_abnormal [Term] id: WBPhenotype:0000263 name: axoneme_short def: "The microbule-based fibrillar bundle in the core of the cilium is reduced in length compared to axonemes of similar cells in normal animals. " [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000262 ! axoneme_morphology_abnormal [Term] id: WBPhenotype:0000264 name: cAMP_chemotaxis_defective def: "Failure to move towards cAMP." [WB:cab, WB:cgc387, WB:WBPaper00001481, WB:WBPaper00002033] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001463 ! cAMP_chemotaxis_abnormal [Term] id: WBPhenotype:0000265 name: odorant_positive_chemotaxis_abnormal def: "Movement towards typically attractive volatile organic chemicals is altered. Typically sensed by the AWA and AWC neurons" [WB:cab, WB:cgc1786, WB:WBPerson2021] is_a: WBPhenotype:0000635 ! positive_chemotaxis_abnormal is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_abnormal [Term] id: WBPhenotype:0000266 name: cell_cleavage_abnormal is_a: WBPhenotype:0000746 ! cell_division_abnormal [Term] id: WBPhenotype:0000267 name: cell_cleavage_delayed is_a: WBPhenotype:0000266 ! cell_cleavage_abnormal [Term] id: WBPhenotype:0000268 name: P_cell_cleavage_delayed is_a: WBPhenotype:0000267 ! cell_cleavage_delayed [Term] id: WBPhenotype:0000269 name: unclassified subset: phenotype_slim_wb is_a: WBPhenotype:0000886 ! Abnormal [Term] id: WBPhenotype:0000270 name: pleiotropic_defects_severe_early_emb def: "Often multiple pronuclei, aberrant cytoplasmic texture, drop in overall pace of development, osmotic sensitivity." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001007 ! other_abnormality_early_emb [Term] id: WBPhenotype:0000272 name: egg_laying_irregular is_a: WBPhenotype:0000640 ! egg_laying_abnormal [Term] id: WBPhenotype:0000273 name: thrashing_reduced def: "The number of body thrashes in a given period of time are reduced compared with wild-type worms." [WB:cab, WB:cgc7388] is_a: WBPhenotype:0001700 ! swimming_abnormal [Term] id: WBPhenotype:0000274 name: dead_eggs_laid def: "Animals lay eggs that are inviable." [WB:cab] is_a: WBPhenotype:0000640 ! egg_laying_abnormal is_a: WBPhenotype:0000806 ! hermaphrodite_fertility_abnormal [Term] id: WBPhenotype:0000275 name: organism_UV_hypersensitive is_a: WBPhenotype:0000143 ! organism_UV_response_abnormal [Term] id: WBPhenotype:0000276 name: organism_X_ray_response_abnormal is_a: WBPhenotype:0000686 ! organism_ionizing_radiation_response_abnormal [Term] id: WBPhenotype:0000277 name: rhythm_slow subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000278 name: body_region_pigmentation_abnormal is_a: WBPhenotype:0000521 ! pigmentation_abnormal [Term] id: WBPhenotype:0000279 name: spicule_insertion_defective is_a: WBPhenotype:0001414 ! male_mating_defective is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_abnormal [Term] id: WBPhenotype:0000280 name: breaks_in_alae is_a: WBPhenotype:0001412 ! alae_morphology_abnormal [Term] id: WBPhenotype:0000281 name: male_sex_muscle_development_abnormal is_a: WBPhenotype:0000669 ! sex_muscle_development_abnormal [Term] id: WBPhenotype:0000282 name: hermaphrodite_sex_muscle_development_abnormal is_a: WBPhenotype:0000669 ! sex_muscle_development_abnormal [Term] id: WBPhenotype:0000283 name: vulva_uterus_connection_defective def: "Animals exhibit defects in the continuity of lumen between the vulva and uterus." [WB:WBPaper00003386, WB:WBPaper00006298, WB:WBPaper00027236, WB:WBPaper00027316, WB:WBPerson712] synonym: "AC block" NARROW [] relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_abnormal [Term] id: WBPhenotype:0000284 name: sperm_transfer_defective is_a: WBPhenotype:0001414 ! male_mating_defective is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_abnormal [Term] id: WBPhenotype:0000285 name: ray_tips_swollen is_a: WBPhenotype:0000505 ! male_ray_morphology_abnormal [Term] id: WBPhenotype:0000286 name: embryo_disorganized is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000287 name: vulval_invagination_L4_abnormal is_a: WBPhenotype:0000699 ! vulva_development_abnormal [Term] id: WBPhenotype:0000288 name: distal_germline_abnormal synonym: "distal_germ_line_abnormal" RELATED [] is_a: WBPhenotype:0000812 ! germ_cell_development_abnormal [Term] id: WBPhenotype:0000289 name: uterus_morphology_abnormal relationship: part_of WBPhenotype:0001335 ! hermaphrodite_reproductive_system_morphology_abnormal [Term] id: WBPhenotype:0000290 name: sperm_absent def: "Animals lack fully specialized male gametes that are competent for fertilization. " [WB:WBPerson2021] is_a: WBPhenotype:0000395 ! no_differentiated_gametes [Term] id: WBPhenotype:0000291 name: no_oocytes def: "Hermaphrodites lack fully specialized female gametes that are competent for fertilization. " [WB:WBPerson2021] is_a: WBPhenotype:0000395 ! no_differentiated_gametes [Term] id: WBPhenotype:0000292 name: organ_system_pigmentation_abnormal is_a: WBPhenotype:0000521 ! pigmentation_abnormal [Term] id: WBPhenotype:0000293 name: alimentary_system_pigmentation_abnormal is_a: WBPhenotype:0000292 ! organ_system_pigmentation_abnormal [Term] id: WBPhenotype:0000294 name: intestine_dark synonym: "Din" BROAD three_letter_name [] relationship: part_of WBPhenotype:0000293 ! alimentary_system_pigmentation_abnormal [Term] id: WBPhenotype:0000295 name: thermotolerance_increased is_a: WBPhenotype:0000146 ! organism_temperature_response_abnormal [Term] id: WBPhenotype:0000296 name: spicules_crumpled is_a: WBPhenotype:0000443 ! spicule_morphology_abnormal [Term] id: WBPhenotype:0000297 name: rays_fused is_a: WBPhenotype:0000505 ! male_ray_morphology_abnormal [Term] id: WBPhenotype:0000298 name: rays_displaced is_a: WBPhenotype:0000505 ! male_ray_morphology_abnormal [Term] id: WBPhenotype:0000299 name: sensillum_morphology_abnormal def: "Animals exhibit abnormalities in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in normal animals." [WB:WBPaper00000214, WB:WBPaper00000938, WB:WBPerson712] synonym: "chemosensory_cell_morphology_abnormal" RELATED [] is_a: WBPhenotype:0000604 ! nervous_system_morphology_abnormal [Term] id: WBPhenotype:0000300 name: amphid_sheath_cell_morphology_abnormal def: "Animals exhibit deviations in the structure or composition of the amphid sensillum cell that ensheathes the dendrite tips of channel neurons and wing cell dedritic processes, from that observed in normal animals. Sheath cells in normal animals have highly invaginated and vesiculated surfaces, which provide a specialized environment for the dendritic structures." [WB:WBPaper00000214, WB:WBPaper00000503, WB:WBPaper00000822, WB:WBPerson 712] is_a: WBPhenotype:0001527 ! amphid_phasmid_sensillum_morphology_abnormal [Term] id: WBPhenotype:0000301 name: distal_tip_cell_reflex_failure def: "A migrating distal tip cell (DTC) fails to follow the stereotypical U-shaped path, which results in the formation of non-reflexed gonadal arm." [WB:WBPaper00029151, WB:WBPerson2021] is_a: WBPhenotype:0000195 ! distal_tip_cell_migration_abnormal [Term] id: WBPhenotype:0000302 name: benzaldehyde_chemotaxis_defective def: "Failure to move towards typically attractive concentrations of benzaldehyde." [WB:WBPaper00001786] is_a: WBPhenotype:0001060 ! AWC_odorant_chemotaxis_defective is_a: WBPhenotype:0001468 ! benzaldehyde_chemotaxis_abnormal [Term] id: WBPhenotype:0000303 name: diacetyl_chemotaxis_defective def: "Failure to move towards typically attractive concentrations of diacetyl." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001470 ! diacetyl_chemotaxis_abnormal [Term] id: WBPhenotype:0000304 name: isoamyl_alcohol_chemotaxis_defective def: "Failure to move towards typically attractive concentrations of isoamyl alcohol." [WB:cab, WB:cgc1786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001472 ! isoamyl_alcohol_chemotaxis_abnormal [Term] id: WBPhenotype:0000305 name: pheromone_sensation_abnormal is_a: WBPhenotype:0000132 ! pheromone_induced_dauer_formation_abnormal [Term] id: WBPhenotype:0000306 name: transgene_expression_abnormal def: "Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism" [WB:WBPerson557] subset: phenotype_slim_wb is_a: WBPhenotype:0000717 ! gene_expression_abnormal [Term] id: WBPhenotype:0000307 name: dauer_pheromone_sensation_defective is_a: WBPhenotype:0001479 ! dauer_pheromone_sensation_abnormal [Term] id: WBPhenotype:0000308 name: dauer_development_abnormal def: "Any abnormality in the processes that govern development of the dauer larva, a developmentally arrested, alternative third larval stage that is specialized for survival under harsh, or otherwise unfavorable, environmental conditions." [WB:kmva] is_a: WBPhenotype:0000049 ! postembryonic_development_abnormal [Term] id: WBPhenotype:0000309 name: SDS_sensitive_dauer is_a: WBPhenotype:0001546 ! dauer_resistance_to_harsh_conditions_abnormal [Term] id: WBPhenotype:0000310 name: cilia_absent def: "Neurons lack the finger-like dendritic projections, which are observed extending from similar cells in normal animals." [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000615 ! cilia_morphology_abnormal [Term] id: WBPhenotype:0000312 name: dauer_pheromone_production_defective is_a: WBPhenotype:0000191 ! organism_crowding_response_abnormal is_a: WBPhenotype:0001547 ! dauer_metabolism_abnormal [Term] id: WBPhenotype:0000313 name: meiotic_progression_during_oogenesis_abnormal def: "Oocytes show defects in their initial entry or progression through the meiotic pathway (such as failure to exit diakinesis)." [WB:WBPaper00026997, WB:WBPerson2021] is_a: WBPhenotype:0000186 ! oogenesis_abnormal [Term] id: WBPhenotype:0000314 name: scrawny is_a: WBPhenotype:0000231 ! body_size_abnormal [Term] id: WBPhenotype:0000315 name: mechanosensation_abnormal alt_id: WBPhenotype:0000513 def: "Alteration with respect to perception or response to mechanical stimuli." [WB:cab] subset: phenotype_slim_wb synonym: "Mec" BROAD three_letter_name [] synonym: "touch_response_abnormal" EXACT [] is_a: WBPhenotype:0000525 ! organism_behavior_abnormal is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_abnormal [Term] id: WBPhenotype:0000316 name: touch_resistant_tail def: "Animal does not advance with characteristic forward movement when struck or stroked in the posterior region, usually with a hair or similar fiber. The posterior region lies between the vulva and the tail." [WB:WBPaper00000502, WB:WBPaper00001133, WB:WBPaper00001705, WB:WBPerson557] synonym: "touch_insensitive_tail" RELATED [] synonym: "touch_resistant_posterior_body" BROAD [] is_a: WBPhenotype:0000456 ! touch_resistant [Term] id: WBPhenotype:0000317 name: head_withdrawal_defective is_a: WBPhenotype:0000315 ! mechanosensation_abnormal [Term] id: WBPhenotype:0000318 name: cell_cycle_delayed is_a: WBPhenotype:0000740 ! cell_cycle_abnormal [Term] id: WBPhenotype:0000319 name: large alt_id: WBPhenotype:0000348 synonym: "body_size_enlarged" EXACT [] is_a: WBPhenotype:0000231 ! body_size_abnormal [Term] id: WBPhenotype:0000320 name: reduced_viability_after_freezing is_a: WBPhenotype:0000141 ! stress_induced_lethality_increased [Term] id: WBPhenotype:0000321 name: nose_morphology_abnormal is_a: WBPhenotype:0000071 ! head_morphology_abnormal [Term] id: WBPhenotype:0000322 name: nose_rounded is_a: WBPhenotype:0000321 ! nose_morphology_abnormal [Term] id: WBPhenotype:0000323 name: head_swollen is_a: WBPhenotype:0000071 ! head_morphology_abnormal [Term] id: WBPhenotype:0000324 name: short def: "Animals exhibit a decreased body length compared to normal animals of the same developmental stage." [WB:WBPerson712] is_a: WBPhenotype:0000231 ! body_size_abnormal [Term] id: WBPhenotype:0000325 name: arecoline_hypersensitive is_a: WBPhenotype:0001579 ! cholinergic_agonist_hypersensitive [Term] id: WBPhenotype:0000326 name: arecoline_resistant is_a: WBPhenotype:0001578 ! cholinergic_agonist_resistant [Term] id: WBPhenotype:0000327 name: corpus_contraction_defect is_a: WBPhenotype:0000747 ! pharyngeal_contraction_defective [Term] id: WBPhenotype:0000328 name: terminal_bulb_contraction_abnormal def: "Alterations/defects in the rhythmic contractions of the terminal bulb, such as timing, strength etc. Contraction of the terminal bulb inverts the grinder, allowing bacteria in front of the grinder to be broken up and transported to the intestine." [WB:WBPaper00001696] is_a: WBPhenotype:0000980 ! pharyngeal_contraction_abnormal [Term] id: WBPhenotype:0000329 name: pumping_asynchronous def: "The rhythmic contractions of the corpus and terminal bulb (which normally occur simultaneously) are not synchronized. " [WB:WBPaper00001696] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_abnormal [Term] id: WBPhenotype:0000330 name: pharyngeal_relaxation_defective def: " Defects in the rhythmic pharyngeal relaxations that impact wild-type feeding behavior. Pharyngeal relaxation (which follows a contraction event) facilitates bacterial trapping within the pharynx while expelling liquid." [WB:WBPaper00001709] is_a: WBPhenotype:0001004 ! pharyngeal_relaxation_abnormal [Term] id: WBPhenotype:0000331 name: inhibitors_of_na_k_atpase_resistant def: "Animals are resistant to the physiological changes/effects caused by certain concentrations of sodium potassium ATPase antagonists." [WB:WBPerson2021] synonym: "ouabain resistant" NARROW [] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000332 name: inhibitors_of_sodium_potassium_ATPase_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000333 name: pharyngeal_pumps_brief is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_abnormal [Term] id: WBPhenotype:0000334 name: isthmus_corpus_slippery def: "Inefficient trapping and posterior transport of bacteria within the corpus and isthmus. Bacteria in the corpus and isthmus are swept anteriorly (instead of being retained) during pharyngeal relaxation." [WB:WBPaper00001696] is_a: WBPhenotype:0000335 ! pharynx_slippery [Term] id: WBPhenotype:0000335 name: pharynx_slippery def: "Bacteria which are normally swept posteriorly during pharyngeal contraction appear to slip anteriorly during pharyngeal relaxation. Consequently bacteria are inefficiently transported within the pharynx and the pharyngeal lumen tends to become distended with bacteria. " [WB:WBPaper00001696] is_a: WBPhenotype:0000634 ! pharyngeal_pumping_abnormal [Term] id: WBPhenotype:0000336 name: terminal_bulb_relaxation_abnormal def: "Alterations/defects in the rhythmic relaxations of the terminal bulb. Relaxation of the terminal bulb returns the grinder to its relaxed forward position." [WB:WBPaper00001696] relationship: part_of WBPhenotype:0000330 ! pharyngeal_relaxation_defective [Term] id: WBPhenotype:0000337 name: grinder_relaxation_defective def: "Failure of the grinder to come to a full relaxed position between pumps." [WB:WBPaper00001709] is_a: WBPhenotype:0001480 ! grinder_relaxation_abnormal [Term] id: WBPhenotype:0000338 name: tail_swelling def: "Tail swelling in the anal region that can result from, but is not necessarily restricted to, infection from the nematode-specific bacterial pathogen, Microbacterium nematophilum." [WB:cab, WB:WBPaper00026735] synonym: "Dar" BROAD three_letter_name [] synonym: "deformed_anal_region" RELATED [] is_a: WBPhenotype:0000073 ! tail_morphology_abnormal [Term] id: WBPhenotype:0000339 name: transient_bloating is_a: WBPhenotype:0000862 ! bloated [Term] id: WBPhenotype:0000340 name: imipramine_resistant is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0001598 ! inhibitor_of_serotonin_uptake_abnormal [Term] id: WBPhenotype:0000341 name: imipramine_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000342 name: bursa_morphology_abnormal relationship: part_of WBPhenotype:0000070 ! male_tail_morphology_abnormal [Term] id: WBPhenotype:0000344 name: cloacal_structures_protrude is_a: WBPhenotype:0000908 ! cloacal_morphology_abnormal [Term] id: WBPhenotype:0000345 name: VPC_cell_division_abnormal is_a: WBPhenotype:0000746 ! cell_division_abnormal [Term] id: WBPhenotype:0000346 name: adult_pigmentation_abnormal is_a: WBPhenotype:0001009 ! developmental_pigmentation_abnormal [Term] id: WBPhenotype:0000347 name: rectal_development_abnormal relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_abnormal [Term] id: WBPhenotype:0000349 name: flaccid synonym: "floppy" RELATED [] synonym: "limp" RELATED [] is_a: WBPhenotype:0000001 ! body_posture_abnormal [Term] id: WBPhenotype:0000350 name: hermaphrodite_tail_spike is_a: WBPhenotype:0000073 ! tail_morphology_abnormal [Term] id: WBPhenotype:0000351 name: failure_to_hatch is_a: WBPhenotype:0000048 ! hatching_abnormal is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0000352 name: backing_uncoordinated def: "Backing uncoordinated: Jerky backward movement." [WB:WBPaper00001709] is_a: WBPhenotype:0001005 ! backward_locomotion_abnormal [Term] id: WBPhenotype:0000353 name: backing_increased def: "Animals spend more time backing than WT under the same conditions." [WB:cab] is_a: WBPhenotype:0001005 ! backward_locomotion_abnormal [Term] id: WBPhenotype:0000354 name: cell_differentiation_abnormal def: "The ability of a less specialized cell to become a more specialized cell type is disrupted. Differentiation impacts diverse cellular properties such as size, shape, polarity, gene expression and responsiveness to signals/cues." [WB:WBPerson2021] subset: phenotype_slim_wb is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000355 name: HSN_differentiation_precocious is_a: WBPhenotype:0000354 ! cell_differentiation_abnormal [Term] id: WBPhenotype:0000356 name: spermatogenesis_delayed def: "The differentiation of immature germ cells to functional sperm occurs much later than normal." [WB:WBPaper00005566, WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis_abnormal [Term] id: WBPhenotype:0000357 name: unfertilized_oocytes_laid is_a: WBPhenotype:0000640 ! egg_laying_abnormal [Term] id: WBPhenotype:0000358 name: extra_cell_division_postembryonic synonym: "supernumerary_cell_divisions" RELATED [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000359 name: tunicamycin_response_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0000360 name: cytoplasmic_streaming_defective is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000361 name: lima_bean_arrest synonym: "arrest_during_epiboly" RELATED [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000867 ! embryonic_arrest [Term] id: WBPhenotype:0000362 name: blastocoel_abnormal is_a: WBPhenotype:0000047 ! gastrulation_abnormal [Term] id: WBPhenotype:0000363 name: cell_division_slow is_a: WBPhenotype:0000746 ! cell_division_abnormal [Term] id: WBPhenotype:0000364 name: gut_granule_birefringence_misplaced relationship: part_of WBPhenotype:0000902 ! intestinal_cell_morphology_abnormal [Term] id: WBPhenotype:0000365 name: embryo_osmotic_integrity_abnormal_early_emb def: "Embryo fills egg shell, and lyses upon dissection or during recording." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000041 ! osmotic_integrity_abnormal is_a: WBPhenotype:0001178 ! egg_integrity_abnormal_early_emb [Term] id: WBPhenotype:0000366 name: three_fold_arrest def: "Cessation of development that normally occurs 520-620min after the first cleavage at 20C, the stage between the 2-fold and fully elongated embryo." [WB:WBPerson101] synonym: "active_elongation_arrest" RELATED [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000779 ! late_embryonic_arrest [Term] id: WBPhenotype:0000367 name: comma_arrest_emb synonym: "Emb" BROAD three_letter_name [] synonym: "end_of_epiboly_arrest" RELATED [] is_a: WBPhenotype:0000864 ! early_elongation_arrest [Term] id: WBPhenotype:0000368 name: one_point_five_fold_arrest_emb def: "Cessation of development that normally occurs 420-460 min after the first embryonic cleavage at 20C, the stage between the comma and 2-fold embryo." [WB:WBPerson101] synonym: "arrest_beginning_elongation" RELATED [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000864 ! early_elongation_arrest [Term] id: WBPhenotype:0000369 name: pretzel_arrest synonym: "Emb" BROAD three_letter_name [] synonym: "end_of_elongation_arrest" RELATED [] is_a: WBPhenotype:0000779 ! late_embryonic_arrest [Term] id: WBPhenotype:0000370 name: egg_long is_a: WBPhenotype:0000037 ! egg_morphology_abnormal [Term] id: WBPhenotype:0000371 name: cell_division_incomplete is_a: WBPhenotype:0000417 ! cell_division_failure [Term] id: WBPhenotype:0000372 name: no_polar_body_formation is_a: WBPhenotype:0000775 ! meiosis_abnormal [Term] id: WBPhenotype:0000373 name: egg_shape_variable is_a: WBPhenotype:0000037 ! egg_morphology_abnormal [Term] id: WBPhenotype:0000374 name: early_divisions_prolonged is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000375 name: later_divisions_prolonged is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000376 name: no_uterine_cavity is_a: WBPhenotype:0000289 ! uterus_morphology_abnormal [Term] id: WBPhenotype:0000377 name: canal_lumen_morphology_abnormal relationship: part_of WBPhenotype:0000704 ! excretory_canal_morphology_abnormal [Term] id: WBPhenotype:0000378 name: pharyngeal_pumping_shallow is_a: WBPhenotype:0000634 ! pharyngeal_pumping_abnormal [Term] id: WBPhenotype:0000379 name: head_notched is_a: WBPhenotype:0000071 ! head_morphology_abnormal [Term] id: WBPhenotype:0000380 name: expulsion_infrequent is_a: WBPhenotype:0000996 ! expulsion_defective [Term] id: WBPhenotype:0000381 name: serotonin_reuptake_inhibitor_resistant is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000382 name: serotonin_reuptake_inhibitor_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000383 name: lipid_synthesis_defective is_a: WBPhenotype:0000725 ! lipid_metabolism_abnormal [Term] id: WBPhenotype:0000384 name: axon_guidance_abnormal def: "Any alteration in the cue-directed extension of an axon towards a specific target site. (Axon guidance often depends on a combination of attractive and repulsive cues)." [GO:0048846, WB:WBPerson2021] synonym: "axon_pathfinding_abnormal" RELATED [] is_a: WBPhenotype:0001224 ! axon_outgrowth_abnormal [Term] id: WBPhenotype:0000385 name: sperm_excess def: "Animals produce an increased sperm population compared to normal." [WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis_abnormal [Term] id: WBPhenotype:0000386 name: genotoxic_induced_apoptosis_abnormal synonym: "DNA_damage_induced_apoptosis_abnormal" RELATED [] is_a: WBPhenotype:0000730 ! apoptosis_abnormal [Term] id: WBPhenotype:0000387 name: sperm_nonmotile is_a: WBPhenotype:0000987 ! germ_cell_physiology_abnormal [Term] id: WBPhenotype:0000388 name: sperm_morphology_abnormal is_a: WBPhenotype:0000900 ! germ_cell_morphology_abnormal [Term] id: WBPhenotype:0000389 name: hermaphrodite_sperm_fertilization_defective is_a: WBPhenotype:0000694 ! hermaphrodite_sterile [Term] id: WBPhenotype:0000390 name: spermatid_activation_defective def: "Round sessile spermatids fail to mature into spermatozoa (polarized cells with a motile pseudopod), upon copulation or treatment with proteases." [WB:WBPaper00000884, WB:WBPaper00027300, WB:WBPaper00031282, WB:WBPerson2021] synonym: "spermiogenesis defective " RELATED [] is_a: WBPhenotype:0000670 ! spermatogenesis_abnormal [Term] id: WBPhenotype:0000391 name: defecation_missing_motor_steps is_a: WBPhenotype:0000650 ! defecation_abnormal [Term] id: WBPhenotype:0000392 name: intestinal_fluorescence_increased relationship: part_of WBPhenotype:0000293 ! alimentary_system_pigmentation_abnormal [Term] id: WBPhenotype:0000393 name: cell_migration_failure def: "Orderly movement of cells from one site to another is abolished. " [WB:WBPerson2021] is_a: WBPhenotype:0000594 ! cell_migration_abnormal [Term] id: WBPhenotype:0000394 name: electrophoretic_variant_protein is_a: WBPhenotype:0000112 ! protein_expression_abnormal [Term] id: WBPhenotype:0000395 name: no_differentiated_gametes def: "Animals are agametic (lack mature germ cells)." [WB:WBPerson2021] is_a: WBPhenotype:0000894 ! germ_cell_differentiation_abnormal [Term] id: WBPhenotype:0000396 name: non_reflexed_gonad_arms def: "Gonadal arms fail to bend or curve into the stereotypical U-shaped pattern (often due to migration defects in the linker cell or distal tip cell). " [WB:WBPaper00005086, WB:WBPaper00029151, WB:WBPerson2021] is_a: WBPhenotype:0000399 ! somatic_gonad_development_abnormal [Term] id: WBPhenotype:0000397 name: harsh_body_touch_resistant def: "Does not respond to prodding with a fine platinum wire or similar tool." [WB:WBPaper00000502] synonym: "harsh_body_touch_insensitive" RELATED [] is_a: WBPhenotype:0000456 ! touch_resistant [Term] id: WBPhenotype:0000398 name: light_body_touch_resistant def: "Does not respond to stroking to the head or tail with a hair or similar fiber, but does respond to stronger mechanical stimuli such as prodding with a fine platinum wire or similar tool." [WB:WBPaper00000502] synonym: "light_body_touch_insensitive" RELATED [] is_a: WBPhenotype:0000456 ! touch_resistant [Term] id: WBPhenotype:0000399 name: somatic_gonad_development_abnormal relationship: part_of WBPhenotype:0000691 ! gonad_development_abnormal [Term] id: WBPhenotype:0000400 name: somatic_gonad_primordium_development_defective is_a: WBPhenotype:0000399 ! somatic_gonad_development_abnormal [Term] id: WBPhenotype:0000401 name: no_uterus is_a: WBPhenotype:0000624 ! reproductive_system_development_abnormal [Term] id: WBPhenotype:0000402 name: avoids_bacterial_lawn is_a: WBPhenotype:0000659 ! feeding_behavior_abnormal [Term] id: WBPhenotype:0000403 name: sperm_transfer_initiation_defective is_a: WBPhenotype:0000284 ! sperm_transfer_defective [Term] id: WBPhenotype:0000404 name: delayed_hatching is_a: WBPhenotype:0000048 ! hatching_abnormal [Term] id: WBPhenotype:0000405 name: giant_oocytes is_a: WBPhenotype:0001260 ! oocyte_morphology_abnormal [Term] id: WBPhenotype:0000406 name: lumpy is_a: WBPhenotype:0000535 ! organism_morphology_abnormal [Term] id: WBPhenotype:0000407 name: ray_loss is_a: WBPhenotype:0000199 ! male_tail_sensory_ray_development_abnormal [Term] id: WBPhenotype:0000408 name: dauer_recovery_inhibited is_a: WBPhenotype:0000127 ! dauer_recovery_abnormal [Term] id: WBPhenotype:0000409 name: organism_morphology_variable synonym: "Vab" BROAD three_letter_name [] is_a: WBPhenotype:0000535 ! organism_morphology_abnormal [Term] id: WBPhenotype:0000410 name: no_defecation_cycle is_a: WBPhenotype:0000207 ! defecation_cycle_abnormal [Term] id: WBPhenotype:0000411 name: rod_like_larval_lethal def: "Animals die as rigid, rod-like second larval stage (L2) larvae. This defect is often caused by the misspecification of the excretory duct cell." [WB:WBPaper00001366, WB:WBPaper00002764, WB:WBPerson2021] synonym: "Let" RELATED [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000035 ! larval_body_morphology_abnormal is_a: WBPhenotype:0000054 ! larval_lethal [Term] id: WBPhenotype:0000412 name: octanol_chemotaxis_defective def: "Failure to execute the characteristic avoidance response to 1-octanol." [WB:WBPaper00002314] is_a: WBPhenotype:0001448 ! odorant_negative_chemotaxis_defective is_a: WBPhenotype:0001452 ! octanol_chemotaxis_abnormal [Term] id: WBPhenotype:0000413 name: pharyngeal_muscle_paralyzed def: "Immobilized pharyngeal muscle. Often characterized by lack of pumping and lack of response to external stimulation." [WB:cab, WB:WBPerson557] is_a: WBPhenotype:0000980 ! pharyngeal_contraction_abnormal [Term] id: WBPhenotype:0000414 name: cell_fate_transformation def: "The cell takes on a different identity than that to which it was initially committed. " [GO:0045165, WB:WBPaper00002924, WB:WBPerson712] is_a: WBPhenotype:0000216 ! cell_fate_specification_abnormal [Term] id: WBPhenotype:0000415 name: necrotic_cell_death_abnormal is_a: WBPhenotype:0001173 ! non_apoptotic_cell_death_abnormal [Term] id: WBPhenotype:0000416 name: yolk_synthesis_abnormal synonym: "vitellogenin_synthesis_abnormal" RELATED [] is_a: WBPhenotype:0001093 ! intestinal_physiology_abnormal [Term] id: WBPhenotype:0000417 name: cell_division_failure is_a: WBPhenotype:0000746 ! cell_division_abnormal [Term] id: WBPhenotype:0000418 name: intestinal_cell_division_failure is_a: WBPhenotype:0000417 ! cell_division_failure [Term] id: WBPhenotype:0000419 name: L3_lethal def: "Animals die at the L3 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000058 ! late_larval_lethal is_a: WBPhenotype:0000116 ! mid_larval_lethal [Term] id: WBPhenotype:0000420 name: levamisole_hypersensitive synonym: "tetramisole_hypersensitive" RELATED [] is_a: WBPhenotype:0000845 ! levamisole_response_abnormal is_a: WBPhenotype:0001579 ! cholinergic_agonist_hypersensitive [Term] id: WBPhenotype:0000421 name: levamisole_resistant def: "Animals are resistant to the physiological changes/effects caused by certain concentrations of levamisole (a cholinergic agonist). Resistance to levamisole is often assayed via body contraction response, ventral tail curling response etc." [WB:WBPaper00000484, WB:WBPerson2021] synonym: "tetramisole_resistant" RELATED [] is_a: WBPhenotype:0000845 ! levamisole_response_abnormal is_a: WBPhenotype:0001578 ! cholinergic_agonist_resistant [Term] id: WBPhenotype:0000422 name: twitcher def: "Animals have an uncoordinated phenotype of spasmodic muscle twitching superimposed on normal sinusoidal motion." [WB:WBPaper00000484] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000423 name: head_muscle_contraction_abnormal is_a: WBPhenotype:0000611 ! muscle_system_physiology_abnormal [Term] id: WBPhenotype:0000424 name: antibody_staining_abnormal is_a: WBPhenotype:0000112 ! protein_expression_abnormal [Term] id: WBPhenotype:0000425 name: antibody_staining_reduced is_a: WBPhenotype:0000424 ! antibody_staining_abnormal [Term] id: WBPhenotype:0000426 name: antibody_staining_increased is_a: WBPhenotype:0000424 ! antibody_staining_abnormal [Term] id: WBPhenotype:0000427 name: no_cuticle is_a: WBPhenotype:0000201 ! cuticle_development_abnormal [Term] id: WBPhenotype:0000428 name: no_adult_cuticle is_a: WBPhenotype:0000427 ! no_cuticle [Term] id: WBPhenotype:0000429 name: copulatory_structure_development_abnormal relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_abnormal [Term] id: WBPhenotype:0000430 name: male_copulatory_structure_development_abnormal is_a: WBPhenotype:0000429 ! copulatory_structure_development_abnormal [Term] id: WBPhenotype:0000431 name: hermaphrodite_copulatory_structure_development_abnormal is_a: WBPhenotype:0000429 ! copulatory_structure_development_abnormal [Term] id: WBPhenotype:0000432 name: male_copulatory_structure_absent is_a: WBPhenotype:0000430 ! male_copulatory_structure_development_abnormal [Term] id: WBPhenotype:0000433 name: DNA_synthesis_abnormal is_a: WBPhenotype:0000732 ! DNA_metabolism_abnormal [Term] id: WBPhenotype:0000434 name: sexual_maturation_defective is_a: WBPhenotype:0000624 ! reproductive_system_development_abnormal [Term] id: WBPhenotype:0000436 name: protein_subcellular_localization_abnormal alt_id: WBPhenotype:0000435 def: "Any change in the subcellular localization of a protein." [] synonym: "protein_localization_abnormal" EXACT [] is_a: WBPhenotype:0001408 ! pattern_protein_expression_abnormal [Term] id: WBPhenotype:0000438 name: retarded_heterochronic_alterations is_a: WBPhenotype:0000033 ! developmental_timing_abnormal [Term] id: WBPhenotype:0000439 name: precocious_heterochronic_alterations is_a: WBPhenotype:0000033 ! developmental_timing_abnormal [Term] id: WBPhenotype:0000440 name: long_excretory_canals relationship: part_of WBPhenotype:0000704 ! excretory_canal_morphology_abnormal [Term] id: WBPhenotype:0000441 name: tail_rounded is_a: WBPhenotype:0000073 ! tail_morphology_abnormal [Term] id: WBPhenotype:0000442 name: larval_development_retarded is_a: WBPhenotype:0000750 ! larval_development_abnormal [Term] id: WBPhenotype:0000443 name: spicule_morphology_abnormal is_a: WBPhenotype:0001024 ! male_morphology_abnormal [Term] id: WBPhenotype:0000444 name: bursa_elongated is_a: WBPhenotype:0000342 ! bursa_morphology_abnormal [Term] id: WBPhenotype:0000445 name: yolk_synthesis_in_males synonym: "vitellogenin_synthesis_in_males" RELATED [] is_a: WBPhenotype:0000416 ! yolk_synthesis_abnormal [Term] id: WBPhenotype:0000446 name: supernumerary_molt is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000447 name: adult_development_abnormal is_a: WBPhenotype:0000049 ! postembryonic_development_abnormal [Term] id: WBPhenotype:0000448 name: adult_cuticle_development_abnormal is_a: WBPhenotype:0000447 ! adult_development_abnormal [Term] id: WBPhenotype:0000449 name: second_adult_cuticle is_a: WBPhenotype:0000448 ! adult_cuticle_development_abnormal [Term] id: WBPhenotype:0000450 name: swollen_male_tail is_a: WBPhenotype:0000070 ! male_tail_morphology_abnormal [Term] id: WBPhenotype:0000451 name: head_protrusion is_a: WBPhenotype:0000071 ! head_morphology_abnormal [Term] id: WBPhenotype:0000452 name: tail_protrusions is_a: WBPhenotype:0000073 ! tail_morphology_abnormal [Term] id: WBPhenotype:0000453 name: body_protrusions is_a: WBPhenotype:0000072 ! body_morphology_abnormal [Term] id: WBPhenotype:0000454 name: head_twisted is_a: WBPhenotype:0000071 ! head_morphology_abnormal [Term] id: WBPhenotype:0000455 name: jerky_movement is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000456 name: touch_resistant def: "Any alteration in characteristic response with respect to perception or transmission of a touch stimulus. " [WB:WBPerson557] synonym: "touch_insensitive" RELATED [] is_a: WBPhenotype:0000315 ! mechanosensation_abnormal [Term] id: WBPhenotype:0000457 name: organism_starvation_hypersensitive is_a: WBPhenotype:0000147 ! organism_starvation_response_abnormal [Term] id: WBPhenotype:0000458 name: starvation_resistant is_a: WBPhenotype:0000147 ! organism_starvation_response_abnormal [Term] id: WBPhenotype:0000459 name: pesticide_response_abnormal is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_abnormal [Term] id: WBPhenotype:0000460 name: paraquat_response_abnormal synonym: "methyl_viologen_response_abnormal" RELATED [] is_a: WBPhenotype:0000459 ! pesticide_response_abnormal is_a: WBPhenotype:0001620 ! organism_oxidative_stress_response_abnormal [Term] id: WBPhenotype:0000461 name: paraquat_resistant is_a: WBPhenotype:0000460 ! paraquat_response_abnormal [Term] id: WBPhenotype:0000462 name: paraquat_hypersensitive synonym: "reactive_oxygen_species_hypersensitive" BROAD [WB:WBPaper00031296] is_a: WBPhenotype:0000460 ! paraquat_response_abnormal [Term] id: WBPhenotype:0000463 name: metabolic_pathway_abnormal def: "Animals exhibit deficiencies or alterations in the processes that are responsible for many of the chemical changes in living organisms, including anabolism and catabolism. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GO:0008152, WB:WBPerson712] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0000464 name: oxygen_response_abnormal is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_abnormal [Term] id: WBPhenotype:0000465 name: high_oxygen_resistant is_a: WBPhenotype:0000464 ! oxygen_response_abnormal [Term] id: WBPhenotype:0000466 name: high_oxygen_hypersensitive is_a: WBPhenotype:0000464 ! oxygen_response_abnormal [Term] id: WBPhenotype:0000467 name: age_associated_fluorescence_increased is_a: WBPhenotype:0001009 ! developmental_pigmentation_abnormal [Term] id: WBPhenotype:0000468 name: age_associated_fluorescence_reduced is_a: WBPhenotype:0001009 ! developmental_pigmentation_abnormal [Term] id: WBPhenotype:0000469 name: Q_neuroblast_lineage_migration_abnormal def: "The daughters of the Q neuroblasts migrate in the wrong direction in relation to the a/p axis of the animal and/or do not migrate to the full extent as they do in normal animals." [WB:WBPaper00001954, WB:WBPaper00031356, WB:WBPerson712] is_a: WBPhenotype:0001140 ! neuron_migration_abnormal [Term] id: WBPhenotype:0000470 name: HSN_migration_abnormal def: "Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo. " [WB:WBPaper00001836, WB:WBPerson2021] is_a: WBPhenotype:0001229 ! abnormal_anterior_neuron_migration [Term] id: WBPhenotype:0000471 name: ALM_migration_abnormal def: "Any variation in the normal posterior movement of the ALM mechanosensory neurons from their birthplace (anterior to the V1 hypodermal cell) to positions in between the V2 and V3 cells in the embryo." [WB:WBPaper00001304, WB:WBPaper00003058, WB:WBPerson2021] is_a: WBPhenotype:0001520 ! abnormal_posterior_neuron_migration [Term] id: WBPhenotype:0000472 name: endoderm_absent is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000473 name: progressive_paralysis def: "Young larvae move normally but adults become increasingly sluggish/paralyzed as they age." [WB:WBPaper00001709] is_a: WBPhenotype:0000644 ! paralyzed [Term] id: WBPhenotype:0000474 name: muscle_attachment_abnormal is_a: WBPhenotype:0000622 ! muscle_system_development_abnormal [Term] id: WBPhenotype:0000475 name: muscle_detached is_a: WBPhenotype:0000474 ! muscle_attachment_abnormal [Term] id: WBPhenotype:0000476 name: progressive_muscle_detachment is_a: WBPhenotype:0000474 ! muscle_attachment_abnormal [Term] id: WBPhenotype:0000477 name: nucleolus_refraction_abnormal is_a: WBPhenotype:0000722 ! nucleolus_abnormal [Term] id: WBPhenotype:0000478 name: isothermal_tracking_behavior_abnormal def: "Deviation from a tendency for animals to track towards their cultivation temperature and within their cultivation temperature." [WB:WBPaper00002214] subset: phenotype_slim_wb synonym: "thermotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000479 name: egg_pale is_a: WBPhenotype:0000970 ! embryonic_pigmentation_abnormal is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000480 name: pyrazine_chemotaxis_defective def: "Failure to move towards typically attractive concentrations of pyrazine." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001474 ! pyrazine_chemotaxis_abnormal [Term] id: WBPhenotype:0000481 name: negative_chemotaxis_abnormal def: "Any variation, compared to wild type, in the directed movement of a worm guided by a lower concentration, in a concentration gradient of a specific chemical." [GO:0050919, WB:cab] synonym: "chemical_avoidance_abnormal" RELATED [] synonym: "chemoaversion_abnormal" RELATED [] is_a: WBPhenotype:0001434 ! chemotaxis_abnormal [Term] id: WBPhenotype:0000482 name: garlic_chemotaxis_defective def: "Failure to execute the characteristic avoidance response to garlic, a water soluble repellent." [WB:WBPaper00001374] is_a: WBPhenotype:0001449 ! aqueous_negative_chemotaxis_defective is_a: WBPhenotype:0001451 ! garlic_chemotaxis_abnormal [Term] id: WBPhenotype:0000483 name: no_gut_granules is_a: WBPhenotype:0000103 ! gut_granule_development_abnormal [Term] id: WBPhenotype:0000484 name: embryo_small is_a: WBPhenotype:0001136 ! embryonic_morphology_abnormal [Term] id: WBPhenotype:0000485 name: dauer_death_increased synonym: "reduced_dauer_survival" RELATED [] is_a: WBPhenotype:0000159 ! dauer_arrest_abnormal [Term] id: WBPhenotype:0000486 name: colchicine_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000487 name: colchicine_resistant is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000488 name: chloroquinone_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000489 name: chloroquinone_resistant is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000490 name: pharynx_disorganized is_a: WBPhenotype:0000707 ! pharyngeal_development_abnormal [Term] id: WBPhenotype:0000491 name: isthmus_morphology_abnormal def: "Any observed morphological defects of the isthmus." [WB:WBPerson2021] synonym: "isthmus_malformed" RELATED [] is_a: WBPhenotype:0000709 ! pharyngeal_morphology_abnormal [Term] id: WBPhenotype:0000492 name: corpus_morphology_abnormal def: "Any observed morphological defects of the corpus" [WB:WBPerson2021] synonym: "corpus_malformed" RELATED [] is_a: WBPhenotype:0000709 ! pharyngeal_morphology_abnormal [Term] id: WBPhenotype:0000493 name: metacorpus_morphology_abnormal def: "Any observed morphological defects of the metacorpus." [WB:WBPerson2021] synonym: "metacarpas_malformed" RELATED [] is_a: WBPhenotype:0000709 ! pharyngeal_morphology_abnormal [Term] id: WBPhenotype:0000494 name: two_fold_arrest def: "Cessation of development that normally occurs 460-520 min after the first cleavage at 20C, the stage between the 1.5-fold and 3-fold embryo." [WB:WBPerson101] is_a: WBPhenotype:0000779 ! late_embryonic_arrest [Term] id: WBPhenotype:0000495 name: ray_ectopic is_a: WBPhenotype:0000199 ! male_tail_sensory_ray_development_abnormal [Term] id: WBPhenotype:0000496 name: male_posterid_sensilla_absent relationship: part_of WBPhenotype:0001008 ! male_nervous_system_development_abnormal [Term] id: WBPhenotype:0000497 name: organism_gamma_ray_response_abnormal is_a: WBPhenotype:0000686 ! organism_ionizing_radiation_response_abnormal [Term] id: WBPhenotype:0000498 name: methyl_methanesulfonate_response_abnormal synonym: "MMS_response_abnormal" RELATED [] is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000499 name: ethyl_methanesulfonate_response_abnormal synonym: "EMS_response_abnormal" RELATED [] is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000500 name: acetylcholinesterase_inhibitor_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive is_a: WBPhenotype:0001290 ! acetylcholinesterase_inhibitor_response_abnormal [Term] id: WBPhenotype:0000501 name: left_handed_roller synonym: "Rol" RELATED [] is_a: WBPhenotype:0000645 ! roller [Term] id: WBPhenotype:0000502 name: right_handed_roller synonym: "Rol" BROAD three_letter_name [] is_a: WBPhenotype:0000645 ! roller [Term] id: WBPhenotype:0000503 name: endoreduplication_abnormal is_a: WBPhenotype:0000732 ! DNA_metabolism_abnormal [Term] id: WBPhenotype:0000504 name: nuclear_division_abnormal subset: phenotype_slim_wb synonym: "karyokinesis_abnormal" RELATED [] is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000505 name: male_ray_morphology_abnormal def: "Animals exhibit deviations in the structure or organization of any of the nine bilateral finger-like sensory sensilla that project from the tail and embed in the male fan. Normal male rays project from the tail in a radial pattern with a smooth and slightly tapered appearance. Although one neuronal member of each ray sensillum is exposed to the outside, male rays rarely take up dye. " [WB:WBPaper00000932, WB:WBPaper00001328, WB:WBPaper00002149, WB:WBPaper00029016, WB:WBPerson712] synonym: "Ram" BROAD three_letter_name [] is_a: WBPhenotype:0000299 ! sensillum_morphology_abnormal relationship: part_of WBPhenotype:0001358 ! male_nervous_system_morphology_abnormal [Term] id: WBPhenotype:0000506 name: bursa_swollen is_a: WBPhenotype:0000342 ! bursa_morphology_abnormal [Term] id: WBPhenotype:0000507 name: acetylcholine_levels_abnormal is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0000508 name: nonsense_mRNA_accumulation is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0000509 name: sperm_pseudopod_abnormal is_a: WBPhenotype:0000388 ! sperm_morphology_abnormal [Term] id: WBPhenotype:0000510 name: vulval_invagination_abnormal_L4 def: "The characteristic Christmas-tree shaped invagination formed by the terminal vulval cells at the mid-late L4 stage is altered." [WB:WBPaper00001738, WB:WBPerson2021] is_a: WBPhenotype:0000695 ! vulva_morphology_abnormal [Term] id: WBPhenotype:0000511 name: nuclear_positioning_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000512 name: VNC_nuclear_positioning_abnormal is_a: WBPhenotype:0000511 ! nuclear_positioning_abnormal [Term] id: WBPhenotype:0000514 name: rubber_band is_a: WBPhenotype:0000315 ! mechanosensation_abnormal [Term] id: WBPhenotype:0000515 name: ventral_nerve_cord_development_abnormal def: "An abnormality in a process whose specific outcome is the development and/or maintenance of the ventral nerve cord." [WB:WBPerson557] is_a: WBPhenotype:0000945 ! neuropil_development_abnormal [Term] id: WBPhenotype:0000516 name: ventral_cord_disorganized is_a: WBPhenotype:0000976 ! ventral_cord_patterning_abnormal [Term] id: WBPhenotype:0000517 name: behavior_abnormal is_a: WBPhenotype:0000886 ! Abnormal [Term] id: WBPhenotype:0000518 name: development_abnormal def: "Any alteration in the progression of an integrated living unit (a cell, tissue, organ or organism) over time from an initial condition to a later condition." [GO:0032502, WB:WBPerson2021] is_a: WBPhenotype:0000886 ! Abnormal [Term] id: WBPhenotype:0000519 name: physiology_abnormal is_a: WBPhenotype:0000886 ! Abnormal [Term] id: WBPhenotype:0000520 name: morphology_abnormal def: "The animal deviates in the form, structure or composition of any of its parts." [WB:WBPerson712] is_a: WBPhenotype:0000886 ! Abnormal [Term] id: WBPhenotype:0000521 name: pigmentation_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000886 ! Abnormal [Term] id: WBPhenotype:0000522 name: organism_region_behavior_abnormal relationship: part_of WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000523 name: chemical_response_abnormal is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_abnormal [Term] id: WBPhenotype:0000524 name: bleach_response_abnormal is_a: WBPhenotype:0001379 ! organism_toxic_chemical_response_abnormal [Term] id: WBPhenotype:0000525 name: organism_behavior_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000517 ! behavior_abnormal [Term] id: WBPhenotype:0000526 name: cell_pigmentation_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000521 ! pigmentation_abnormal [Term] id: WBPhenotype:0000527 name: organism_pigmentation_abnormal subset: phenotype_slim_wb synonym: "Abnormal_Coloration" RELATED [] is_a: WBPhenotype:0000521 ! pigmentation_abnormal [Term] id: WBPhenotype:0000528 name: body_region_development_abnormal relationship: part_of WBPhenotype:0000531 ! organism_development_abnormal [Term] id: WBPhenotype:0000529 name: cell_development_abnormal def: "Any variation in the progression of a cell from when it is first formed to when it becomes a mature structure when compared to wild type." [GO:0048468, WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000518 ! development_abnormal [Term] id: WBPhenotype:0000530 name: organ_system_development_abnormal def: "Any variation in the progression of an organismal system from its formation to the mature structure when compared to wild type." [GO:0048731, WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000518 ! development_abnormal [Term] id: WBPhenotype:0000531 name: organism_development_abnormal def: "The abnormal progression of a worm at any time from its formation to adulthood." [WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000518 ! development_abnormal [Term] id: WBPhenotype:0000532 name: body_region_morphology_abnormal relationship: part_of WBPhenotype:0000535 ! organism_morphology_abnormal [Term] id: WBPhenotype:0000533 name: cell_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000520 ! morphology_abnormal [Term] id: WBPhenotype:0000534 name: organ_system_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000520 ! morphology_abnormal [Term] id: WBPhenotype:0000535 name: organism_morphology_abnormal def: "Body morphological defects." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395] subset: phenotype_slim_wb synonym: "Bmd" BROAD three_letter_name [] is_a: WBPhenotype:0000520 ! morphology_abnormal [Term] id: WBPhenotype:0000536 name: cell_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000519 ! physiology_abnormal [Term] id: WBPhenotype:0000537 name: synaptic_input_abnormal is_a: WBPhenotype:0000816 ! neuron_development_abnormal [Term] id: WBPhenotype:0000538 name: synaptic_output_abnormal is_a: WBPhenotype:0000816 ! neuron_development_abnormal [Term] id: WBPhenotype:0000539 name: dorsal_nerve_cord_development_abnormal is_a: WBPhenotype:0000945 ! neuropil_development_abnormal [Term] id: WBPhenotype:0000540 name: muscle_arm_development_abnormal is_a: WBPhenotype:0000087 ! body_wall_cell_development_abnormal [Term] id: WBPhenotype:0000541 name: cord_commissures_fail_to_reach_target def: "Axon tracts that grow circumferentially around the animal fail to complete the connection between the ventral and dorsal nerve cords." [WB:WBPaper00001499, WB:WBPaper00028984, WB:WBPerson712] is_a: WBPhenotype:0000014 ! cord_commissures_abnormal [Term] id: WBPhenotype:0000542 name: fat is_a: WBPhenotype:0000231 ! body_size_abnormal [Term] id: WBPhenotype:0000543 name: forward_kinker is_a: WBPhenotype:0000002 ! kinker [Term] id: WBPhenotype:0000544 name: backward_kinker is_a: WBPhenotype:0000002 ! kinker [Term] id: WBPhenotype:0000545 name: egg_retention def: "Eggs are retained in the uterus at a later stage than in wild-type worms." [WB:cab] synonym: "late_eggs_laid" RELATED [] is_a: WBPhenotype:0000006 ! egg_laying_defective [Term] id: WBPhenotype:0000546 name: early_eggs_laid def: "Eggs are laid at an earlier stage of development when compared with wild type." [WB:cab] is_a: WBPhenotype:0000005 ! hyperactive_egg_laying [Term] id: WBPhenotype:0000547 name: starved synonym: "Eat" RELATED [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000548 name: muscle_dystrophy def: "Progressive degeneration of muscle." [WB:cab] is_a: WBPhenotype:0000611 ! muscle_system_physiology_abnormal [Term] id: WBPhenotype:0000549 name: head_muscle_dystrophy def: "Progressive degeneration of the head muscle." [WB:cab] is_a: WBPhenotype:0000548 ! muscle_dystrophy relationship: part_of WBPhenotype:0001002 ! head_muscle_behavior_abnormal [Term] id: WBPhenotype:0000550 name: body_muscle_dystrophy def: "Progressive muscle degeneration." [WB:cab] synonym: "body_wall_muscle_dystrophy" RELATED [] is_a: WBPhenotype:0000548 ! muscle_dystrophy relationship: part_of WBPhenotype:0000596 ! body_behavior_abnormal [Term] id: WBPhenotype:0000551 name: omega_turns is_a: WBPhenotype:0001702 ! directionality_abnormal [Term] id: WBPhenotype:0000552 name: GABA_levels_abnormal is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0000553 name: muscle_ultrastructure_disorganized alt_id: WBPhenotype:0000714 def: "Animals exhibit structurally disorganized muscle fibers." [] comment: Disorganized muscle fibers display a weak and abnormal birefringency pattern when examined using polarized optics. synonym: "disorganized_muscle" EXACT [] synonym: "muscle_birefringence_abnormal" RELATED [] is_a: WBPhenotype:0000603 ! muscle_system_morphology_abnormal [Term] id: WBPhenotype:0000554 name: hypoosmotic_shock_hypersensitive def: "Failure to efficiently adjust to a decline in ambient solute concentrations, thereby causing the body to swell and explode." [WB:WBPaper00000484, WB:WBPerson2021] is_a: WBPhenotype:0000041 ! osmotic_integrity_abnormal [Term] id: WBPhenotype:0000555 name: drug_adaptation_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0000556 name: dopamine_adaptation_abnormal is_a: WBPhenotype:0000555 ! drug_adaptation_abnormal [Term] id: WBPhenotype:0000557 name: dopamine_adaptation_defective is_a: WBPhenotype:0000556 ! dopamine_adaptation_abnormal [Term] id: WBPhenotype:0000558 name: calcium_channel_modulator_response_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0000559 name: calcium_channel_modulator_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive is_a: WBPhenotype:0000558 ! calcium_channel_modulator_response_abnormal [Term] id: WBPhenotype:0000560 name: calcium_channel_modulator_resistant is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0000558 ! calcium_channel_modulator_response_abnormal [Term] id: WBPhenotype:0000561 name: head_levamisole_resistant def: "Heads do not exhibit rapid muscular contractions in response to certain concentrations of levamisole, a cholinergic agonist. [ >10uM for intact animals, >1uM for cut animals] " [WB:WBPaper00000484] synonym: "head_tetramisole_resistant" RELATED [] is_a: WBPhenotype:0000421 ! levamisole_resistant [Term] id: WBPhenotype:0000562 name: body_levamisole_resistant synonym: "body_tetramisole_resistant" RELATED [] is_a: WBPhenotype:0000421 ! levamisole_resistant [Term] id: WBPhenotype:0000563 name: shrinker is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000564 name: echo_defecation_cycle def: "A repetition of muscle contractions that make up the defecation motor program before the onset of the next cycle is expected to occur. " [WB:WBPaper00002305, WB:WBPaper00003765, WB:WBPerson712] is_a: WBPhenotype:0000207 ! defecation_cycle_abnormal [Term] id: WBPhenotype:0000565 name: coiler synonym: "curler" RELATED [] is_a: WBPhenotype:0000001 ! body_posture_abnormal is_a: WBPhenotype:0004017 ! locomotor_coordination_abnormal [Term] id: WBPhenotype:0000566 name: ventral_coiler synonym: "ventral_curler" RELATED [] is_a: WBPhenotype:0000565 ! coiler [Term] id: WBPhenotype:0000567 name: dorsal_coiler synonym: "dorsal_curler" RELATED [] is_a: WBPhenotype:0000565 ! coiler [Term] id: WBPhenotype:0000568 name: axon_ultrastructure_abnormal def: "Animals display deviations in the structure or organization of the components of the axon, compared to that observed in normal animals." [WB:WBPaper00001499, WB:WBPerson712] is_a: WBPhenotype:0000180 ! axon_morphology_abnormal [Term] id: WBPhenotype:0000569 name: axon_varicosities def: "Animals display markedly swollen areas along their axons, which are larger than normal synaptic varicosities. These large varicosities are not observed in normal animals." [WB:WBPaper00001499, WB:WBPaper00024595, WB:WBPerson712] is_a: WBPhenotype:0000568 ! axon_ultrastructure_abnormal [Term] id: WBPhenotype:0000570 name: axon_cisternae def: "Axons of animals contain flattened membrane-bound compartments. These cisternae-like structures are not observed in normal animals." [WB:WBPaper00001499, WB:WBPaper00024595, WB:WBPerson712] is_a: WBPhenotype:0000568 ! axon_ultrastructure_abnormal [Term] id: WBPhenotype:0000571 name: abnormal_axon_vesicle def: "Axons of animals exhibit deviations in the gross structure or organization of its vesicles, e.g. spherical, membrane-bound, fluid-filled organelles, compared to that observed in normal animals." [WB:WBPaper00001499, WB:WBPerson712] is_a: WBPhenotype:0000568 ! axon_ultrastructure_abnormal [Term] id: WBPhenotype:0000572 name: neuronal_outgrowth_abnormal is_a: WBPhenotype:0000816 ! neuron_development_abnormal [Term] id: WBPhenotype:0000573 name: neuronal_branching_abnormal is_obsolete: true [Term] id: WBPhenotype:0000574 name: excretory_canal_short relationship: part_of WBPhenotype:0000704 ! excretory_canal_morphology_abnormal [Term] id: WBPhenotype:0000575 name: organ_system_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000519 ! physiology_abnormal [Term] id: WBPhenotype:0000576 name: organism_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000519 ! physiology_abnormal [Term] id: WBPhenotype:0000577 name: organism_homeostasis_metabolism_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000576 ! organism_physiology_abnormal [Term] id: WBPhenotype:0000578 name: body_axis_development_abnormal is_a: WBPhenotype:0000528 ! body_region_development_abnormal [Term] id: WBPhenotype:0000579 name: organism_segment_development_abnormal is_a: WBPhenotype:0000531 ! organism_development_abnormal [Term] id: WBPhenotype:0000580 name: organism_segment_behavior_abnormal is_a: WBPhenotype:0000522 ! organism_region_behavior_abnormal [Term] id: WBPhenotype:0000581 name: body_axis_morphology_abnormal is_a: WBPhenotype:0000532 ! body_region_morphology_abnormal [Term] id: WBPhenotype:0000582 name: organism_segment_morphology_abnormal is_a: WBPhenotype:0000535 ! organism_morphology_abnormal [Term] id: WBPhenotype:0000583 name: dumpy def: "Worms are shorter and stouter than wild type." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497] synonym: "Dpy" BROAD three_letter_name [] is_a: WBPhenotype:0000231 ! body_size_abnormal [Term] id: WBPhenotype:0000584 name: synaptic_transmission_abnormal def: "Any variation in the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse compared to normal." [GO:0007268, WB:cab] is_a: WBPhenotype:0000612 ! nervous_system_physiology_abnormal [Term] id: WBPhenotype:0000585 name: cell_homeostasis_metabolism_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000586 name: bleach_hypersensitive is_a: WBPhenotype:0000524 ! bleach_response_abnormal [Term] id: WBPhenotype:0000587 name: lectin_staining_abnormal is_obsolete: true [Term] id: WBPhenotype:0000588 name: no_male_abnormality_scored is_obsolete: true [Term] id: WBPhenotype:0000589 name: no_hermaphrodite_abnormality_scored is_obsolete: true [Term] id: WBPhenotype:0000590 name: cell_corpse_number_abnormal is_a: WBPhenotype:0000730 ! apoptosis_abnormal [Term] id: WBPhenotype:0000591 name: metal_response_abnormal is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_abnormal [Term] id: WBPhenotype:0000592 name: copper_response_abnormal is_a: WBPhenotype:0000591 ! metal_response_abnormal [Term] id: WBPhenotype:0000593 name: copper_hypersensitive is_a: WBPhenotype:0000592 ! copper_response_abnormal [Term] id: WBPhenotype:0000594 name: cell_migration_abnormal def: "Any variation in the orderly movement of cells from one site to another compared to wild type." [GO:0016477, WB:cab] subset: phenotype_slim_wb synonym: "Mig" BROAD three_letter_name [] synonym: "migration_of_cells_abnormal" RELATED [] is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000595 name: head_behavior_abnormal def: "Activity characteristic of the head is altered." [WB:cab] is_a: WBPhenotype:0000580 ! organism_segment_behavior_abnormal [Term] id: WBPhenotype:0000596 name: body_behavior_abnormal def: "Activity characteristic of the body is altered." [WB:cab] is_a: WBPhenotype:0000580 ! organism_segment_behavior_abnormal [Term] id: WBPhenotype:0000597 name: tail_behavior_abnormal is_a: WBPhenotype:0000580 ! organism_segment_behavior_abnormal [Term] id: WBPhenotype:0000598 name: alimentary_system_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000534 ! organ_system_morphology_abnormal [Term] id: WBPhenotype:0000599 name: coelomic_system_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000534 ! organ_system_morphology_abnormal [Term] id: WBPhenotype:0000600 name: epithelial_system_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000534 ! organ_system_morphology_abnormal [Term] id: WBPhenotype:0000601 name: excretory_secretory_system_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000534 ! organ_system_morphology_abnormal [Term] id: WBPhenotype:0000602 name: excretory_system_morphology_abnormal relationship: part_of WBPhenotype:0000601 ! excretory_secretory_system_morphology_abnormal [Term] id: WBPhenotype:0000603 name: muscle_system_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000534 ! organ_system_morphology_abnormal [Term] id: WBPhenotype:0000604 name: nervous_system_morphology_abnormal def: "Animals exhibit alterations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in normal animals." [WB:WBbt\:0005735, WB:WBPerson712] subset: phenotype_slim_wb synonym: "neuroanatomical_defective" RELATED [] is_a: WBPhenotype:0000534 ! organ_system_morphology_abnormal [Term] id: WBPhenotype:0000605 name: reproductive_system_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000534 ! organ_system_morphology_abnormal [Term] id: WBPhenotype:0000606 name: alimentary_system_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000575 ! organ_system_physiology_abnormal [Term] id: WBPhenotype:0000607 name: coelomic_system_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000575 ! organ_system_physiology_abnormal [Term] id: WBPhenotype:0000608 name: epithelial_system_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000575 ! organ_system_physiology_abnormal [Term] id: WBPhenotype:0000609 name: excretory_secretory_system_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000575 ! organ_system_physiology_abnormal [Term] id: WBPhenotype:0000610 name: excretory_system_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000575 ! organ_system_physiology_abnormal [Term] id: WBPhenotype:0000611 name: muscle_system_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000575 ! organ_system_physiology_abnormal [Term] id: WBPhenotype:0000612 name: nervous_system_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000575 ! organ_system_physiology_abnormal [Term] id: WBPhenotype:0000613 name: reproductive_system_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000575 ! organ_system_physiology_abnormal [Term] id: WBPhenotype:0000614 name: GLR_development_abnormal is_a: WBPhenotype:0000942 ! accessory_cell_development_abnormal [Term] id: WBPhenotype:0000615 name: cilia_morphology_abnormal def: "Animals exhibit abnormalities in the structure or organization of the microtubule-based dendritic projections extending from the cell body, compared to that observed in normal animals. Cilia are classified as channel cilia or wing cilia depending on their placement within the sensillum. Channel cilia of normal animals are cylindrical, extend into the sensillum pore and are exposed to the outside. Wing cilia of normal animals vary in shape, are embedded in the sensillum sheath cell and are not typically refractory to dyes indicating exposure to the outside." [WB:WBPaper00000214, WB:WBPaper00000932, WB:WBPerson712] synonym: "defective_dye_filling_of_cilia" RELATED [] is_a: WBPhenotype:0001526 ! ciliated_neuron_morphology_abnormal [Term] id: WBPhenotype:0000616 name: synapse_morphology_abnormal def: "Animals display deviations in the appearance of the subcellular junctional structure composed of a presynaptic terminal directly apposed to a post-synaptic target and separated by a synaptic cleft, the synapse also has a perisynaptic region, which in normal animals is further away from the active zone and is devoid of synaptic vesicles. " [GO:0045202, WB:WBPaper00027305, WB:WBPerson712] relationship: part_of WBPhenotype:0000604 ! nervous_system_morphology_abnormal [Term] id: WBPhenotype:0000617 name: alimentary_system_development_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000530 ! organ_system_development_abnormal [Term] id: WBPhenotype:0000618 name: coelomic_system_development_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000530 ! organ_system_development_abnormal [Term] id: WBPhenotype:0000619 name: epithelial_system_development_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000530 ! organ_system_development_abnormal [Term] id: WBPhenotype:0000620 name: excretory_secretory_system_development_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000530 ! organ_system_development_abnormal [Term] id: WBPhenotype:0000621 name: excretory_system_development_abnormal def: "Any alteration in the progression of the excretory system over time, from its formation to the mature structure. The excretory system is required for the elimination of metabolic waste, and is comprised of the excretory cell, excretory duct cell and excretory socket cell." [WB:WBPerson2021] subset: phenotype_slim_wb is_a: WBPhenotype:0000530 ! organ_system_development_abnormal relationship: part_of WBPhenotype:0000620 ! excretory_secretory_system_development_abnormal [Term] id: WBPhenotype:0000622 name: muscle_system_development_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000530 ! organ_system_development_abnormal [Term] id: WBPhenotype:0000623 name: nervous_system_development_abnormal def: "Any variation in the progression of nervous tissue over time, from its formation to its mature state compared to normal." [GO:0007399, WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000530 ! organ_system_development_abnormal [Term] id: WBPhenotype:0000624 name: reproductive_system_development_abnormal subset: phenotype_slim_wb synonym: "reproductive_defect" RELATED [] is_a: WBPhenotype:0000530 ! organ_system_development_abnormal [Term] id: WBPhenotype:0000625 name: synaptogenesis_abnormal def: "Any variation in the biosynthesis of a synapse compared to normal." [GO:0007416, WB:cab] is_a: WBPhenotype:0000623 ! nervous_system_development_abnormal [Term] id: WBPhenotype:0000626 name: habituation_abnormal def: "Any variation in the decrease in a behavioral response to a repeated stimulus compared to normal." [GO:0046959, WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000627 name: anesthetic_response_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0000628 name: spindle_assembly_abnormal_early_emb def: "Spindle bipolarity is not established." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001102 ! mitotic_spindle_abnormal_early_emb [Term] id: WBPhenotype:0000629 name: ectopic_neurite_outgrowth def: "Any perturbation that causes an increase in the frequency of neurite (axon or dendrite) outgrowth. As a result, an excess number of neuronal projections are generated." [WB:WBPerson2021] is_a: WBPhenotype:0000572 ! neuronal_outgrowth_abnormal [Term] id: WBPhenotype:0000630 name: quinine_chemotaxis_defective def: "Failure to execute the characteristic avoidance response to quinine, a water soluble repellent." [WB:WBPaper00006481] is_a: WBPhenotype:0001449 ! aqueous_negative_chemotaxis_defective is_a: WBPhenotype:0001454 ! quinine_chemotaxis_abnormal [Term] id: WBPhenotype:0000631 name: drug_response_abnormal def: "Characteristic response(s) to drug(s) is abnormal." [WB:cab] synonym: "drug_response_abnormal" RELATED [] is_a: WBPhenotype:0000523 ! chemical_response_abnormal [Term] id: WBPhenotype:0000632 name: axon_fasciculation_abnormal def: "The ability of axons to converge and form a bundle of nerve fibres (fascicle) is compromised." [GO:0007413, WB:WBPerson2021] is_a: WBPhenotype:0000880 ! axon_development_abnormal [Term] id: WBPhenotype:0000633 name: axon_branching_abnormal def: "Animals display deviations in the number or pattern of axonal tracts stemming from the neuron cell body, compared to that observed in normal animals." [WB:WBPaper00027335, WB:WBPaper00027711, WB:WBPerson712] is_a: WBPhenotype:0000180 ! axon_morphology_abnormal is_a: WBPhenotype:0001224 ! axon_outgrowth_abnormal [Term] id: WBPhenotype:0000634 name: pharyngeal_pumping_abnormal def: "Any variation in the contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes compared to normal." [GO:0043050, WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000635 name: positive_chemotaxis_abnormal def: "Movement towards typical attractive chemicals is altered." [WB:cab, WB:cgc122, WB:cgc387] is_a: WBPhenotype:0001434 ! chemotaxis_abnormal [Term] id: WBPhenotype:0000636 name: neuron_degeneration_abnormal relationship: part_of WBPhenotype:0000612 ! nervous_system_physiology_abnormal [Term] id: WBPhenotype:0000637 name: dauer_formation_abnormal def: "Characteristic entry into the dauer stage is altered." [WB:cab] synonym: "Daf" BROAD three_letter_name [] is_a: WBPhenotype:0000159 ! dauer_arrest_abnormal is_a: WBPhenotype:0000308 ! dauer_development_abnormal [Term] id: WBPhenotype:0000638 name: molt_defect synonym: "Mlt" BROAD three_letter_name [] synonym: "Mult" BROAD [] is_a: WBPhenotype:0000750 ! larval_development_abnormal [Term] id: WBPhenotype:0000639 name: temperature_induced_dauer_formation_abnormal is_a: WBPhenotype:0000146 ! organism_temperature_response_abnormal is_a: WBPhenotype:0001539 ! dauer_induction_abnormal [Term] id: WBPhenotype:0000640 name: egg_laying_abnormal def: "The stage of eggs laid, egg laying cycle, or egg laying in response to external stimuli is altered." [pmid:11813735, pmid:9697864, WB:cab] comment: visual inspection. subset: phenotype_slim_wb synonym: "Egl" BROAD three_letter_name [] synonym: "oviposition_abnormal" RELATED [GO:0018991] is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000641 name: activity_level_abnormal def: "The level of activity normally characteristic of C. elegans is altered." [WB:cab] is_a: WBPhenotype:0000643 ! locomotion_abnormal [Term] id: WBPhenotype:0000642 name: hyperactive def: "Worms move forward or backward with an increased rate of body bends per minute." [WB:cab, WB:WBPaper00004402, WB:WBPaper00006395] synonym: "Hya" BROAD three_letter_name [] is_a: WBPhenotype:0000641 ! activity_level_abnormal [Term] id: WBPhenotype:0000643 name: locomotion_abnormal def: "Any variation in the self-propelled movement of a nematode from one location to another compared to wild type." [GO:0040011, WB:cab] subset: phenotype_slim_wb synonym: "movement_defect" RELATED [] synonym: "Unc" BROAD three_letter_name [] synonym: "uncoordinated" RELATED [] is_a: WBPhenotype:0001206 ! movement_abnormal [Term] id: WBPhenotype:0000644 name: paralyzed def: "Immobilized worm that is not responsive to external mechanical stimulation." [WB:cab] subset: phenotype_slim_wb synonym: "Prl" BROAD three_letter_name [] synonym: "Prz" RELATED [] is_a: WBPhenotype:0001213 ! locomotion_reduced [Term] id: WBPhenotype:0000645 name: roller def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern. In liquid media, wave propogation is helical rather than planar." [WB:cab, WB:cgc31] synonym: "Rol" BROAD three_letter_name [] is_a: WBPhenotype:0004017 ! locomotor_coordination_abnormal [Term] id: WBPhenotype:0000646 name: sluggish def: "Animals move more slowly compared with wild-type animals." [WB:cab] synonym: "lethargic" RELATED [] synonym: "slow" RELATED [] synonym: "Slu" BROAD three_letter_name [] is_a: WBPhenotype:0001213 ! locomotion_reduced [Term] id: WBPhenotype:0000647 name: copulation_abnormal def: "Mating is altered." [WB:cab] subset: phenotype_slim_wb synonym: "Cod" BROAD three_letter_name [] is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000648 name: male_mating_abnormal def: "Characteristic male behavior during mating is altered." [WB:cab] is_a: WBPhenotype:0000647 ! copulation_abnormal is_a: WBPhenotype:0000888 ! male_behavior_abnormal [Term] id: WBPhenotype:0000649 name: vulva_location_abnormal synonym: "Lov" RELATED [] is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_abnormal [Term] id: WBPhenotype:0000650 name: defecation_abnormal def: "Activities characteristic of defecation behavior are altered." [WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000651 name: constipated synonym: "Con" BROAD three_letter_name [] is_a: WBPhenotype:0000650 ! defecation_abnormal [Term] id: WBPhenotype:0000652 name: sensory_system_abnormal relationship: part_of WBPhenotype:0000612 ! nervous_system_physiology_abnormal [Term] id: WBPhenotype:0000653 name: mechanosensory_system_abnormal relationship: part_of WBPhenotype:0000652 ! sensory_system_abnormal [Term] id: WBPhenotype:0000654 name: synaptic_vesicle_exocytosis_abnormal is_a: WBPhenotype:0000728 ! exocytosis_abnormal is_a: WBPhenotype:0001684 ! synaptic_vesicle_homeostasis_abnormal [Term] id: WBPhenotype:0000655 name: GABA_synaptic_transmission_abnormal is_a: WBPhenotype:0000584 ! synaptic_transmission_abnormal [Term] id: WBPhenotype:0000656 name: acetylcholine_synaptic_transmission_abnormal is_a: WBPhenotype:0000584 ! synaptic_transmission_abnormal [Term] id: WBPhenotype:0000657 name: neuronal_synaptic_transmission_abnormal is_a: WBPhenotype:0000584 ! synaptic_transmission_abnormal [Term] id: WBPhenotype:0000658 name: neuromuscular_synaptic_transmission_abnormal is_a: WBPhenotype:0000584 ! synaptic_transmission_abnormal [Term] id: WBPhenotype:0000659 name: feeding_behavior_abnormal subset: phenotype_slim_wb synonym: "Eat" BROAD three_letter_name [] is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000660 name: social_feeding_increased def: "Worms are found in clumps and/or crowded at the border of the bacterial lawn, this behavior is not due to mobility defects." [WB:WBPerson712] synonym: "bordering_increased" RELATED [] synonym: "social_behavior_enhanced" RELATED [] is_a: WBPhenotype:0000659 ! feeding_behavior_abnormal is_a: WBPhenotype:0001291 ! social_behavior_abnormal [Term] id: WBPhenotype:0000661 name: solitary_feeding_increased synonym: "solitary_behavior_enhanced" RELATED [] is_a: WBPhenotype:0000659 ! feeding_behavior_abnormal is_a: WBPhenotype:0001291 ! social_behavior_abnormal [Term] id: WBPhenotype:0000662 name: foraging_behavior_abnormal def: "Animals exhibit uncharacteristic roaming or dwelling activity on food. Roaming is defined as moving in a high-speed forward direction with brief backward movement, often traversing wide regions. Dwelling is defined as low-speed/high turning movement restricted to a confined region." [WB:WBPaper00005621, WB:WBPaper00031455, WB:WBPerson712] subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000663 name: osmotic_avoidance_abnormal def: "Any alteration in the characteristic avoidance response to solutions of high osmotic strength." [WB:WBPerson2021] is_a: WBPhenotype:0000481 ! negative_chemotaxis_abnormal [Term] id: WBPhenotype:0000664 name: exaggerated_body_bends alt_id: WBPhenotype:0004021 synonym: "exaggerated_body_bends" EXACT [] synonym: "loopy" RELATED [] is_a: WBPhenotype:0001703 ! body_bend_abnormal [Term] id: WBPhenotype:0000665 name: connection_of_gonad_abnormal relationship: part_of WBPhenotype:0000605 ! reproductive_system_morphology_abnormal [Term] id: WBPhenotype:0000666 name: ovulation_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000667 name: gonad_displaced is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_abnormal [Term] id: WBPhenotype:0000668 name: endomitotic_oocytes def: "Any abnormality that results in the presence, in proximal gonad arms, of oocytes with distended polyploid nuclei. Such oocytes mature and exit diakinesis, but are often not properly ovulated or fertilized." [WB:kmva] synonym: "arrest_in_meiosis_I" RELATED [] synonym: "Emo" BROAD three_letter_name [] is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_abnormal [Term] id: WBPhenotype:0000669 name: sex_muscle_development_abnormal is_a: WBPhenotype:0000860 ! nonstriated_muscle_development_abnormal relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_abnormal [Term] id: WBPhenotype:0000670 name: spermatogenesis_abnormal alt_id: WBPhenotype:0000895 def: "Any aberrancy in the processes that influence the generation and maturation of spermatozoa (motile sperm)." [GO:0007283, WB:WBPaper00027300, WB:WBPaper00031282, WB:WBPerson2021] synonym: "spermatocyte_germ_cell_differentiation_abnormal" EXACT [] is_a: WBPhenotype:0000894 ! germ_cell_differentiation_abnormal [Term] id: WBPhenotype:0000671 name: resistant_to_copper is_a: WBPhenotype:0000592 ! copper_response_abnormal [Term] id: WBPhenotype:0000672 name: presynaptic_vesicle_cluster_localization_abnormal def: "Animals display deviations in the distribution of transmitter-filled vesicles in relation to the electron-dense membrane specialization of the neuron,compared to that observed in normal animals." [WB:WBPaper00027305, WB:WBPaper00027711, WB:WBPerson712] synonym: "synaptic_vesicle_cluster_localization_abnormal" RELATED [] is_a: WBPhenotype:0000102 ! presynaptic_vesicle_cluster_abnormal [Term] id: WBPhenotype:0000673 name: brood_size_abnormal def: "The characteristic number of offspring produced by a hermaphrodite is altered compared to that of normal animals." [WB:WBPerson557] is_a: WBPhenotype:0000806 ! hermaphrodite_fertility_abnormal [Term] id: WBPhenotype:0000674 name: slow_development synonym: "retarded_development" RELATED [] is_a: WBPhenotype:0000043 ! general_pace_of_development_abnormal [Term] id: WBPhenotype:0000675 name: zygotic_lethal synonym: "Emb" RELATED [] is_a: WBPhenotype:0000213 ! zygotic_development_abnormal [Term] id: WBPhenotype:0000676 name: growth_rate_abnormal is_a: WBPhenotype:0000030 ! growth_abnormal [Term] id: WBPhenotype:0000677 name: chemosensation_defective is_a: WBPhenotype:0001050 ! chemosensation_abnormal [Term] id: WBPhenotype:0000678 name: no_copper_sensitivity is_obsolete: true [Term] id: WBPhenotype:0000679 name: transgene_subcellular_localization_abnormal def: "Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in normal animals." [WB:WBPerson557] is_a: WBPhenotype:0000961 ! pattern_of_transgene_expression_abnormal [Term] id: WBPhenotype:0000680 name: aldicarb_response_abnormal is_a: WBPhenotype:0001290 ! acetylcholinesterase_inhibitor_response_abnormal [Term] id: WBPhenotype:0000681 name: DMPP_response_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0000682 name: feminization_of_germline def: "Hermaphrodites transformed into fertile females; XO animals are somatically male but may produce oocytes instead of, or in addition to, sperm." [pmid:3396865, WB:cab] synonym: "feminization_of_germ line" EXACT [] synonym: "Fog" BROAD three_letter_name [] is_a: WBPhenotype:0000687 ! feminization_of_XX_and_XO_animals is_a: WBPhenotype:0000812 ! germ_cell_development_abnormal [Term] id: WBPhenotype:0000683 name: masculinization_of_germline def: "XX animals are somatically hermaphrodite, but the germ line is sexually transformed from hermaphrodite to male (namely, germ cells that normally would become oocytes are transformed into sperm). By contrast, XO animals are completely normal." [WB:WBPaper00001710, WB:WBPerson2021] synonym: "masculinization of germ line" EXACT [] synonym: "Mog" BROAD three_letter_name [] is_a: WBPhenotype:0000812 ! germ_cell_development_abnormal is_a: WBPhenotype:0001572 ! masculinized [Term] id: WBPhenotype:0000684 name: fewer_germ_cells def: "Germ cell populations are reduced compared to normal animals." [WB:cab, WB:WBPerson2021] synonym: "Fgc" BROAD three_letter_name [] is_a: WBPhenotype:0000823 ! germline_proliferation_abnormal [Term] id: WBPhenotype:0000685 name: larval_growth_slow is_a: WBPhenotype:0001016 ! larval_growth_abnormal [Term] id: WBPhenotype:0000686 name: organism_ionizing_radiation_response_abnormal synonym: "reactive_oxygen_species_abnormal" BROAD [WB:WBPaper00031296] is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000687 name: feminization_of_XX_and_XO_animals def: "Feminization of XX and XO animals such that both develop to become fertile females." [WB:cab] synonym: "Fem" BROAD three_letter_name [] is_a: WBPhenotype:0000049 ! postembryonic_development_abnormal is_a: WBPhenotype:0000624 ! reproductive_system_development_abnormal is_a: WBPhenotype:0000822 ! sex_determination_abnormal [Term] id: WBPhenotype:0000688 name: sterile alt_id: WBPhenotype:0000311 subset: phenotype_slim_wb synonym: "semi_sterile" EXACT [] synonym: "Ste" BROAD three_letter_name [] is_a: WBPhenotype:0001384 ! fertility_reduced [Term] id: WBPhenotype:0000689 name: maternal_sterile def: "Hermaphrodites produce no or very few embryos. This term is a specialization of sterility which is applied when a hermaphrodite is the subject of an experimental treatment and produces no, or few embryos, for example when treated with inhibiting RNA." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557] synonym: "Reduced fecundity of injected worm" EXACT [WB:cgc5599] synonym: "Ste" BROAD three_letter_name [] synonym: "sterile_F0_fertility_problems" RELATED [] is_a: WBPhenotype:0000694 ! hermaphrodite_sterile [Term] id: WBPhenotype:0000690 name: gonad_migration_abnormal synonym: "Gom" BROAD three_letter_name [] relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_abnormal [Term] id: WBPhenotype:0000691 name: gonad_development_abnormal def: "Any alteration in the progression of the gonad over time, from its formation to the mature structure. The gonad is an organ that produces gametes." [GO:0008406, WB:WBPerson2021] synonym: "Gon" RELATED [] synonym: "gonadogenesis_abnormal" RELATED [] is_a: WBPhenotype:0000624 ! reproductive_system_development_abnormal [Term] id: WBPhenotype:0000692 name: male_sterile is_a: WBPhenotype:0000688 ! sterile is_a: WBPhenotype:0000863 ! male_fertility_reduced [Term] id: WBPhenotype:0000693 name: male_sperm_fertilization_defect is_a: WBPhenotype:0000692 ! male_sterile [Term] id: WBPhenotype:0000694 name: hermaphrodite_sterile is_a: WBPhenotype:0000688 ! sterile is_a: WBPhenotype:0001259 ! hermaphrodite_fertility_reduced [Term] id: WBPhenotype:0000695 name: vulva_morphology_abnormal def: "Animals exhibit defects in the gross structure or organization of the hermaphrodite reproductive organ required for depositing eggs and for influencing male mating behavior." [WB:WBPerson712] relationship: part_of WBPhenotype:0001335 ! hermaphrodite_reproductive_system_morphology_abnormal [Term] id: WBPhenotype:0000696 name: everted_vulva def: "The normal eversion process, in which the vulval invagination is turned inside out during the L4-adult molt, is disrupted. Such abnormalities in vulval eversion are primarily due to developmental defects in the somatic gonad (and sometimes vulva)." [WB:cab, WB:WBPaper00001738, WB:WBPerson2021, WB:WBPerson261] synonym: "Evl" BROAD three_letter_name [] is_a: WBPhenotype:0000695 ! vulva_morphology_abnormal [Term] id: WBPhenotype:0000697 name: protruding_vulva def: "Animals produce some vulval tissue (as opposed to a vulvaless mutant), but are unable to undergo normal vulval morphogenesis, which results in the formation of a single protrusion at the site of the vulva." [WB:WBPaper00004408, WB:WBPerson2021] synonym: "Pvl" BROAD three_letter_name [] synonym: "Pvu" BROAD [] is_a: WBPhenotype:0000695 ! vulva_morphology_abnormal [Term] id: WBPhenotype:0000698 name: vulvaless def: "No vulval tissue is produced. This is usually a result of all six vulval precursor cells adopting a 3 nonvulval fate." [WB:WBPaper00001182, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "underinduced" EXACT [] synonym: "Vul" BROAD three_letter_name [] is_a: WBPhenotype:0000219 ! vulval_cell_induction_reduced [Term] id: WBPhenotype:0000699 name: vulva_development_abnormal def: "Any alteration in the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GO:0040025, WB:IA, WB:WBPerson2021] subset: phenotype_slim_wb relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_abnormal [Term] id: WBPhenotype:0000700 name: multivulva def: "Multiple vulva-like protrusions are present along the ventral side of the animal. This is usually a result of all six vulval precursor cells adopting vulval (1 or 2) fates." [WB:WBPaper00001182, WB:WBPerson2021] synonym: "Muv" BROAD three_letter_name [] synonym: "overinduced" EXACT [] is_a: WBPhenotype:0000218 ! vulval_cell_induction_increased [Term] id: WBPhenotype:0000701 name: epithelial_development_abnormal synonym: "hypodermal_development_abnormal" RELATED [] relationship: part_of WBPhenotype:0000619 ! epithelial_system_development_abnormal [Term] id: WBPhenotype:0000702 name: epithelial_cell_fusion_failure xref: PMID:15341747 is_a: WBPhenotype:0000165 ! cell_fusion_abnormal is_a: WBPhenotype:0000701 ! epithelial_development_abnormal [Term] id: WBPhenotype:0000703 name: epithelial_morphology_abnormal synonym: "hypodermal_morphology_abnormal" RELATED [] relationship: part_of WBPhenotype:0000600 ! epithelial_system_morphology_abnormal [Term] id: WBPhenotype:0000704 name: excretory_canal_morphology_abnormal relationship: part_of WBPhenotype:0000916 ! excretory_cell_morphology_abnormal [Term] id: WBPhenotype:0000705 name: intestinal_cell_development_abnormal is_a: WBPhenotype:0000529 ! cell_development_abnormal relationship: part_of WBPhenotype:0000708 ! intestinal_development_abnormal [Term] id: WBPhenotype:0000706 name: gut_granule_biogenesis_reduced synonym: "Glo" BROAD three_letter_name [] synonym: "gut_granule_loss" RELATED [] xref: PMID:15843430 is_a: WBPhenotype:0000103 ! gut_granule_development_abnormal is_a: WBPhenotype:0001430 ! lysosome_organization_biogenesis_abnormal [Term] id: WBPhenotype:0000707 name: pharyngeal_development_abnormal def: "Any alteration in the progression of the pharynx (feeding organ) over time, from its formation to the mature structure. " [GO:0043282, WB:WBPerson2021] relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_abnormal [Term] id: WBPhenotype:0000708 name: intestinal_development_abnormal synonym: "gut_development" RELATED [] relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_abnormal [Term] id: WBPhenotype:0000709 name: pharyngeal_morphology_abnormal relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_abnormal [Term] id: WBPhenotype:0000710 name: intestinal_morphology_abnormal relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_abnormal [Term] id: WBPhenotype:0000711 name: organism_hypersensitive_ionizing_radiation def: "Animals exhibit increased sensitivity to the effects of ion producing radiation compared to normal animals treated the same." [WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0000686 ! organism_ionizing_radiation_response_abnormal [Term] id: WBPhenotype:0000712 name: germ_cell_ionizing_radiation_response_abnormal is_a: WBPhenotype:0000987 ! germ_cell_physiology_abnormal [Term] id: WBPhenotype:0000713 name: spermatocyte_division_abnormal is_a: WBPhenotype:0000987 ! germ_cell_physiology_abnormal [Term] id: WBPhenotype:0000715 name: muscle_excess def: "Any abnormality that results in a greater than wild-type number of embryonic muscle cells." [WB:kmva, WB:WBPaper00001584] synonym: "Mex" BROAD three_letter_name [WB:WBPaper00001584] is_a: WBPhenotype:0000622 ! muscle_system_development_abnormal [Term] id: WBPhenotype:0000716 name: muscle_cell_attachment_abnormal is_a: WBPhenotype:0000990 ! muscle_cell_physiology_abnormal [Term] id: WBPhenotype:0000717 name: gene_expression_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0000718 name: dosage_compensation_abnormal def: "abnormality in the process of normalizing the expression level of X-linked genes between XX and XO animals" [WB:WBPerson363] is_a: WBPhenotype:0000717 ! gene_expression_abnormal [Term] id: WBPhenotype:0000719 name: reporter_gene_expression_abnormal is_obsolete: true [Term] id: WBPhenotype:0000720 name: pattern_of_reporter_gene_expression_abnormal is_obsolete: true [Term] id: WBPhenotype:0000721 name: level_of_reporter_gene_expression_abnormal is_obsolete: true [Term] id: WBPhenotype:0000722 name: nucleolus_abnormal def: "The morphological appearance of nucleoli is abnormal compared to wild type." [WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000724 name: protein_secretion_abnormal is_a: WBPhenotype:0000258 ! cell_secretion_abnormal [Term] id: WBPhenotype:0000725 name: lipid_metabolism_abnormal is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0000726 name: ligand_binding_abnormal is_a: WBPhenotype:0000727 ! enzyme_activity_abnormal [Term] id: WBPhenotype:0000727 name: enzyme_activity_abnormal is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0000728 name: exocytosis_abnormal is_a: WBPhenotype:0000258 ! cell_secretion_abnormal [Term] id: WBPhenotype:0000729 name: cell_death_abnormal def: "Any abnormality in the specific activation or halting of processes within a cell that causes its vital functions to suddenly cease and culminate in cell death." [GO:0008219, WB:cab] subset: phenotype_slim_wb synonym: "Ced" BROAD three_letter_name [] is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000730 name: apoptosis_abnormal def: "Any aberrancy in the processes that influence apoptosis, a form of programmed cell death. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell." [GO:0006915, WB:WBPerson2021] synonym: "Ced" BROAD three_letter_name [] is_a: WBPhenotype:0001172 ! programmed_cell_death_abnormal [Term] id: WBPhenotype:0000731 name: germ_cell_hypersensitive_ionizing_radiation is_a: WBPhenotype:0000712 ! germ_cell_ionizing_radiation_response_abnormal is_a: WBPhenotype:0001324 ! cell_ionizing_radiation_response_abnormal [Term] id: WBPhenotype:0000732 name: DNA_metabolism_abnormal is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000733 name: catalysis_abnormal is_a: WBPhenotype:0000727 ! enzyme_activity_abnormal [Term] id: WBPhenotype:0000734 name: hypodermal_cell_physiology_abnormal relationship: part_of WBPhenotype:0000608 ! epithelial_system_physiology_abnormal [Term] id: WBPhenotype:0000735 name: endoreduplication_of_hypodermal_nuclei_abnormal is_a: WBPhenotype:0000734 ! hypodermal_cell_physiology_abnormal [Term] id: WBPhenotype:0000736 name: autophagic_cell_death_abnormal synonym: "autophagy_abnormal" RELATED [] is_a: WBPhenotype:0000729 ! cell_death_abnormal [Term] id: WBPhenotype:0000737 name: germ_cell_resistant_ionizing_radiation is_a: WBPhenotype:0000712 ! germ_cell_ionizing_radiation_response_abnormal is_a: WBPhenotype:0001324 ! cell_ionizing_radiation_response_abnormal [Term] id: WBPhenotype:0000738 name: organism_environmental_stimulus_response_abnormal def: "Characteristic response to a change in the environment is altered." [WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000739 name: DNA_damage_response_abnormal is_a: WBPhenotype:0000142 ! cell_stress_response_abnormal [Term] id: WBPhenotype:0000740 name: cell_cycle_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000741 name: DNA_damage_checkpoint_abnormal is_a: WBPhenotype:0000740 ! cell_cycle_abnormal [Term] id: WBPhenotype:0000742 name: DNA_recombination_abnormal is_a: WBPhenotype:0000732 ! DNA_metabolism_abnormal [Term] id: WBPhenotype:0000743 name: RNAi_response_abnormal synonym: "Rde" BROAD three_letter_name [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000744 name: transgene_induced_cosuppression_abnormal is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000745 name: transposon_silencing_abnormal is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000746 name: cell_division_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000747 name: pharyngeal_contraction_defective def: "Any defects in the steady rhythmic pharyngeal contractions that impact wild-type feeding behavior. Contractions are necessary for bacterial uptake from the surrounding environment." [WB:WBPaper00001696] is_a: WBPhenotype:0000980 ! pharyngeal_contraction_abnormal [Term] id: WBPhenotype:0000748 name: asymmetric_cell_division_abnormal_early_emb def: "Symmetric (PAR-like) divisions or excessive posterior displacement (zyg-8 like phenotypes)." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal is_a: WBPhenotype:0001235 ! cell_division_polarity_abnormal [Term] id: WBPhenotype:0000749 name: embryonic_development_abnormal def: "Any alteration in the progression of an embryo over time, from zygote formation to hatching." [GO:0009790, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "developmental_defects_detected_in_embryos" RELATED [] is_a: WBPhenotype:0000531 ! organism_development_abnormal [Term] id: WBPhenotype:0000750 name: larval_development_abnormal def: "larval_development_abnormal: Any alteration in the progression of a larva over time, from its formation to the mature structure. The larva is the early, immature form of an animal between hatching and adulthood." [GO:0002164, WB:WBPerson2021] is_a: WBPhenotype:0000049 ! postembryonic_development_abnormal [Term] id: WBPhenotype:0000751 name: L1_larval_development_abnormal def: "Any alteration in the progression of a newly hatched animal through the first larval molt." [WB:WBPerson2021] is_a: WBPhenotype:0000750 ! larval_development_abnormal [Term] id: WBPhenotype:0000752 name: L2_larval_development_abnormal is_a: WBPhenotype:0000750 ! larval_development_abnormal [Term] id: WBPhenotype:0000753 name: L3_larval_development_abnormal is_a: WBPhenotype:0000750 ! larval_development_abnormal [Term] id: WBPhenotype:0000754 name: L4_larval_development_abnormal is_a: WBPhenotype:0000750 ! larval_development_abnormal [Term] id: WBPhenotype:0000755 name: L1_L2_molt_abnormal synonym: "L1_molt" RELATED [] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000756 name: L2_L3_molt_abnormal synonym: "L2_molt" RELATED [] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000757 name: L3_L4_molt_abnormal synonym: "L3_molt" RELATED [] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000758 name: L4_adult_molt_abnormal synonym: "L4_molt" RELATED [] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000759 name: spindle_abnormal_early_emb synonym: "Emb" BROAD [] synonym: "Spd" BROAD three_letter_name [] is_a: WBPhenotype:0000764 ! embryonic_cell_organization_biogenesis_abnormal is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000760 name: spindle_orientation_abnormal_early_emb synonym: "Emb" BROAD [] synonym: "Spn" BROAD three_letter_name [] is_a: WBPhenotype:0000761 ! spindle_position_orientation_abnormal_early_emb is_a: WBPhenotype:0001681 ! spindle_orientation_abnormal [Term] id: WBPhenotype:0000761 name: spindle_position_orientation_abnormal_early_emb synonym: "Emb" BROAD [] synonym: "Spi" RELATED [] synonym: "Spo" BROAD three_letter_name [] is_a: WBPhenotype:0001102 ! mitotic_spindle_abnormal_early_emb [Term] id: WBPhenotype:0000762 name: spindle_position_abnormal_early_emb synonym: "Abs" BROAD three_letter_name [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0000761 ! spindle_position_orientation_abnormal_early_emb [Term] id: WBPhenotype:0000763 name: embryonic_cell_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000764 name: embryonic_cell_organization_biogenesis_abnormal is_a: WBPhenotype:0000749 ! embryonic_development_abnormal is_a: WBPhenotype:0000763 ! embryonic_cell_physiology_abnormal is_a: WBPhenotype:0010002 ! cell_organization_biogenesis_abnormal [Term] id: WBPhenotype:0000765 name: spindle_elongation_integrity_abnormal_early_emb def: "Bipolar spindle shows clear elongation defect." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001102 ! mitotic_spindle_abnormal_early_emb [Term] id: WBPhenotype:0000766 name: centrosome_pair_and_associated_pronuclear_rotation_abnormal synonym: "Rot" BROAD three_letter_name [] is_a: WBPhenotype:0000764 ! embryonic_cell_organization_biogenesis_abnormal [Term] id: WBPhenotype:0000767 name: integrity_of_membranous_organelles_abnormal_early_emb def: "Sparse or enlarged yolk granules." [WB:cab, WB:WBPaper00025054] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_abnormal is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000768 name: cytoplasmic_structure_abnormal_early_emb def: "Areas devoid of yolk granules throughout the embryo." [WB:cab, WB:cgc7141] synonym: "Aberrant_Cytoplasmic_Structure" RELATED [] synonym: "cellular_structure_disorganized" RELATED [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001081 ! cytoplasmic_morphology_abnormal_early_emb [Term] id: WBPhenotype:0000769 name: cytoplasmic_appearance_abnormal_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal is_a: WBPhenotype:0001427 ! cytoplasmic_appearance_abnormal [Term] id: WBPhenotype:0000770 name: embryonic_cell_morphology_abnormal def: "The morphological appearance of embryonic cells is abnormal compared to wild type." [WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000771 name: centrosome_attachment_abnormal_early_emb def: "Centrosomes detach from the male pronucleus." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000770 ! embryonic_cell_morphology_abnormal is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000772 name: sister_chromatid_segregation_abnormal_early_emb def: "Daughter nuclei are deformed and stay close to central cortex, cytokinesis defects." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000773 ! chromosome_segregation_abnormal is_a: WBPhenotype:0001078 ! cytokinesis_abnormal_early_emb [Term] id: WBPhenotype:0000773 name: chromosome_segregation_abnormal def: "Any abnormality in the processes that regulate the apportionment of chromosomes to each of two daughter cells." [WB:kmva] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0000774 name: gametogenesis_abnormal def: "Any aberrancy in the processes that govern the generation and maintenance of gametes." [GO:0007276, WB:WBPerson2021] is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000775 name: meiosis_abnormal def: "Any alteration in the specialized nuclear and cytoplasmic divisions of a single diploid cell, whose specific outcome is the formation of four haploid daughter cells. Meiosis occurs during the formation of gametes." [GO:0007126, WB:WBPerson2021] synonym: "Mei" RELATED [] is_a: WBPhenotype:0000812 ! germ_cell_development_abnormal [Term] id: WBPhenotype:0000776 name: passage_through_meiosis_abnormal_early_emb def: "Male and female PNs not visible; embryo often fills egg shell completely." [WB:cab, WB:cgc71441] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000775 ! meiosis_abnormal is_a: WBPhenotype:0001041 ! meiosis_abnormal_early_emb [Term] id: WBPhenotype:0000777 name: polar_body_extrusion_abnormal_early_emb def: "Unextruded or resorbed polar body(ies) leading to an extra PNs in P0 and/or extra karyomeres in AB/P1." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000775 ! meiosis_abnormal is_a: WBPhenotype:0001147 ! polar_body_abnormal_early_emb [Term] id: WBPhenotype:0000778 name: feeding_inefficient is_a: WBPhenotype:0000659 ! feeding_behavior_abnormal [Term] id: WBPhenotype:0000779 name: late_embryonic_arrest def: "Cessation of development during the last stage of embryogenesis, which normally occurs 620-800 min after the first cleavage at 20C, the stage after elongation." [WB:WBPerson101] is_a: WBPhenotype:0000867 ! embryonic_arrest [Term] id: WBPhenotype:0000780 name: shaker def: "Animals shake by rotating back and forth around their longitudinal axes." [WB:cab, WB:cgc914] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000781 name: thin_filament_abnormal relationship: part_of WBPhenotype:0000553 ! muscle_ultrastructure_disorganized [Term] id: WBPhenotype:0000782 name: thick_filament_abnormal relationship: part_of WBPhenotype:0000553 ! muscle_ultrastructure_disorganized [Term] id: WBPhenotype:0000783 name: M_line_absent is_a: WBPhenotype:0000782 ! thick_filament_abnormal [Term] id: WBPhenotype:0000784 name: male_fertility_abnormal is_a: WBPhenotype:0000145 ! fertility_abnormal [Term] id: WBPhenotype:0000785 name: body_part_pigmentation_abnormal is_a: WBPhenotype:0000278 ! body_region_pigmentation_abnormal [Term] id: WBPhenotype:0000786 name: body_axis_pigmentation_abnormal is_a: WBPhenotype:0000278 ! body_region_pigmentation_abnormal [Term] id: WBPhenotype:0000787 name: posterior_pale is_a: WBPhenotype:0000984 ! posterior_pigmentation_abnormal [Term] id: WBPhenotype:0000788 name: anterior_pale is_a: WBPhenotype:0000971 ! anterior_pigmentation_abnormal [Term] id: WBPhenotype:0000789 name: fluoxetine_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000790 name: fluoxetine_resistant is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000791 name: nose_resistant_to_fluoxetine is_a: WBPhenotype:0000790 ! fluoxetine_resistant [Term] id: WBPhenotype:0000792 name: anterior_body_morphology_abnormal is_a: WBPhenotype:0000072 ! body_morphology_abnormal is_a: WBPhenotype:0001491 ! anterior_region_morphology_abnormal [Term] id: WBPhenotype:0000793 name: posterior_body_morphology_abnormal is_a: WBPhenotype:0000072 ! body_morphology_abnormal is_a: WBPhenotype:0001490 ! posterior_region_morphology_abnormal [Term] id: WBPhenotype:0000794 name: posterior_body_thin is_a: WBPhenotype:0000793 ! posterior_body_morphology_abnormal [Term] id: WBPhenotype:0000795 name: body_axis_behavior_abnormal is_a: WBPhenotype:0000522 ! organism_region_behavior_abnormal [Term] id: WBPhenotype:0000796 name: posterior_body_uncoordinated def: "Posterior of the worm does not move in a sinusoidal motion fashion that is coordinated with the anterior body movement of the worm." [WB:cab] is_a: WBPhenotype:0000797 ! posterior_body_behavior_abnormal [Term] id: WBPhenotype:0000797 name: posterior_body_behavior_abnormal is_a: WBPhenotype:0000795 ! body_axis_behavior_abnormal [Term] id: WBPhenotype:0000798 name: anterior_body_behavior_abnormal is_a: WBPhenotype:0000795 ! body_axis_behavior_abnormal [Term] id: WBPhenotype:0000799 name: anterior_region_development_abnormal is_a: WBPhenotype:0000578 ! body_axis_development_abnormal [Term] id: WBPhenotype:0000800 name: posterior_region_development_abnormal is_a: WBPhenotype:0000578 ! body_axis_development_abnormal [Term] id: WBPhenotype:0000801 name: ventral_region_development_abnormal is_a: WBPhenotype:0000578 ! body_axis_development_abnormal [Term] id: WBPhenotype:0000802 name: dorsal_region_development_abnormal is_a: WBPhenotype:0000578 ! body_axis_development_abnormal [Term] id: WBPhenotype:0000803 name: head_development_abnormal is_a: WBPhenotype:0000579 ! organism_segment_development_abnormal [Term] id: WBPhenotype:0000804 name: body_development_abnormal is_a: WBPhenotype:0000579 ! organism_segment_development_abnormal [Term] id: WBPhenotype:0000805 name: tail_development_abnormal is_a: WBPhenotype:0000579 ! organism_segment_development_abnormal [Term] id: WBPhenotype:0000806 name: hermaphrodite_fertility_abnormal def: "Any departure from the normal time of onset or duration of the fertile period, or production of viable offspring, including number and state of eggs laid" [WB:WBPerson712] is_a: WBPhenotype:0000145 ! fertility_abnormal [Term] id: WBPhenotype:0000807 name: G_lineages_abnormal def: "The descendants of the G1 or G2 exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000808 name: K_lineage_abnormal def: "The descendants of the K precursor cell exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000809 name: male_specific_lineage_abnormal def: "The descendants of a male specific precursor cell exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000810 name: blast_cell_development_abnormal is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000811 name: epithelial_cell_development_abnormal is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000812 name: germ_cell_development_abnormal def: "Any alteration in the progression of the immature germ cell over time, from its formation to the mature structure (gamete)." [GO:0007281, WB:WBPerson2021] synonym: "germline_development_abnormal" RELATED [] relationship: part_of WBPhenotype:0000774 ! gametogenesis_abnormal [Term] id: WBPhenotype:0000813 name: gland_cell_development_abnormal is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000814 name: marginal_cell_development_abnormal is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000815 name: muscle_cell_development_abnormal is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000816 name: neuron_development_abnormal def: "Any alteration in the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO:0048666, WB:WBPerson2021] is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000817 name: uterine_vulval_cell_development_abnormal is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0000818 name: adult_behavior_abnormal def: "Activity characteristic of an adult worm is altered." [WB:cab] is_a: WBPhenotype:0000819 ! postembryonic_behavior_abnormal [Term] id: WBPhenotype:0000819 name: postembryonic_behavior_abnormal def: "Behavior characteristic of postembryonic stage(s) is altered." [WB:cab] is_a: WBPhenotype:0001000 ! developmental_behavior_abnormal [Term] id: WBPhenotype:0000820 name: embryonic_behavior_abnormal def: "Activity characteristic of an embryo is altered." [WB:cab] is_a: WBPhenotype:0001000 ! developmental_behavior_abnormal [Term] id: WBPhenotype:0000821 name: sexually_dimorphic_behavior_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0000822 name: sex_determination_abnormal def: "Any abnormality in the processes that govern the sexually dimorphic development of germline or somatic tissue." [WB:kmva] synonym: "sex_specific_development_abnormal" RELATED [] is_a: WBPhenotype:0000930 ! sexually_dimorphic_development_abnormal [Term] id: WBPhenotype:0000823 name: germline_proliferation_abnormal def: "Nuclear divisions in the germ line are either expanded are reduced." [WB:cab] synonym: "germ_cell_proliferation_abnormal" RELATED [] synonym: "germ_line_proliferation_abnormal" EXACT [] synonym: "glp" BROAD three_letter_name [] is_a: WBPhenotype:0000812 ! germ_cell_development_abnormal [Term] id: WBPhenotype:0000824 name: embryonic_cell_lineage_abnormal def: "The descendants of an embryonic precursor cell exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000093 ! lineage_abnormal [Term] id: WBPhenotype:0000825 name: postembryonic_cell_lineage_abnormal def: "The descendants of a postembryonic precursor cell exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000093 ! lineage_abnormal [Term] id: WBPhenotype:0000826 name: H_lineages_abnormal def: "The descendants of H1 or H2 cells exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000827 name: V_lineages_abnormal def: "The descendants of any of the V precursor cells (V1-V6) exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000828 name: T_lineages_abnormal def: "The descendants of TL or TR cells exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000829 name: Q_lineage_abnormal def: "The descendants of Q L or QR cells exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000830 name: B_lineage_abnormal def: "The descendants of the B cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000809 ! male_specific_lineage_abnormal [Term] id: WBPhenotype:0000831 name: Y_lineage_abnormal def: "The descendants of the Y cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000809 ! male_specific_lineage_abnormal [Term] id: WBPhenotype:0000832 name: C_lineage_abnormal def: "The descendants of the C blastomere exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPaper00001584, WB:WBPerson2021] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000833 name: U_lineage_abnormal def: "The descendants of the U cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000809 ! male_specific_lineage_abnormal [Term] id: WBPhenotype:0000834 name: E_lineage_abnormal def: "The descendants of the E blastomere exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPaper00002870, WB:WBPerson2021] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000835 name: F_lineage_abnormal def: "The descendants of the F cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000809 ! male_specific_lineage_abnormal [Term] id: WBPhenotype:0000836 name: gonadal_lineage_abnormal def: "The descendants of a gonadal precursor cell exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000837 name: hermaphrodite_gonadal_lineage_abnormal def: "The descendants of a gonadal precursor cell exhibit altered developmental programs in the hermaphrodite compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000836 ! gonadal_lineage_abnormal [Term] id: WBPhenotype:0000838 name: male_gonadal_lineage_abnormal def: "The descendants of a gonadal precursor cell exhibit altered developmental programs in the male compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000809 ! male_specific_lineage_abnormal is_a: WBPhenotype:0000836 ! gonadal_lineage_abnormal [Term] id: WBPhenotype:0000839 name: Z1_hermaphrodite_lineage_abnormal def: "Z1 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000837 ! hermaphrodite_gonadal_lineage_abnormal [Term] id: WBPhenotype:0000840 name: Z4_hermaphrodite_lineage_abnormal def: "Z4 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000837 ! hermaphrodite_gonadal_lineage_abnormal [Term] id: WBPhenotype:0000841 name: Z1_male_lineage_abnormal def: "Z1 descendents exhibit altered developmental programs in the male compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000838 ! male_gonadal_lineage_abnormal [Term] id: WBPhenotype:0000842 name: Z4_male_lineage_abnormal def: "Z4 descendants exhibit altered developmental programs in the male compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000838 ! male_gonadal_lineage_abnormal [Term] id: WBPhenotype:0000843 name: male_mating_efficiency_reduced def: "The number of cross progeny sired by males is reduced. " [WB:WBPaper00000179, WB:WBPaper00000608, WB:WBPerson557] is_a: WBPhenotype:0000647 ! copulation_abnormal [Term] id: WBPhenotype:0000844 name: serotonin_induced_pumping_abnormal is_a: WBPhenotype:0000024 ! serotonin_resistant is_a: WBPhenotype:0001232 ! serotonin_response_abnormal is_a: WBPhenotype:0001285 ! induced_pharyngeal_pumping_abnormal [Term] id: WBPhenotype:0000845 name: levamisole_response_abnormal synonym: "tetramisole_response_abnormal" RELATED [] is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0000846 name: presynaptic_region_physiology_abnormal is_a: WBPhenotype:0000584 ! synaptic_transmission_abnormal [Term] id: WBPhenotype:0000847 name: presynaptic_component_localization_abnormal def: "Animals display deviations in the distribution of the constituents that make up the synaptic machinery such as those required for priming, docking or fusion of vesicles at the active zone, compared to that observed in normal animals." [WB:WBPaper00027305, WB:WBPerson712] synonym: "synaptic_component_localization_abnormal" RELATED [] synonym: "synaptic_machinery_localization_abnormal" RELATED [] relationship: part_of WBPhenotype:0001321 ! presynaptic_region_morphology_abnormal [Term] id: WBPhenotype:0000848 name: developmental_delay is_a: WBPhenotype:0000043 ! general_pace_of_development_abnormal [Term] id: WBPhenotype:0000849 name: amphid_physiology_abnormal relationship: part_of WBPhenotype:0000652 ! sensory_system_abnormal [Term] id: WBPhenotype:0000850 name: touch_resistant_anterior_body def: "Animal does not respond to stroking in the anterior body region with a hair or similar fiber. The anterior region is defined as the body region that lies between the posterior bulb of the pharynx and the vulva. " [WB:WBPaper00000502, WB:WBPaper00001705, WB:WBPerson557] synonym: "touch_insensitive_anterior_body" RELATED [] is_a: WBPhenotype:0000456 ! touch_resistant [Term] id: WBPhenotype:0000851 name: ciliated_neuron_physiology_abnormal is_a: WBPhenotype:0000991 ! neuron_physiology_abnormal [Term] id: WBPhenotype:0000852 name: coelomocyte_development_abnormal relationship: part_of WBPhenotype:0000618 ! coelomic_system_development_abnormal [Term] id: WBPhenotype:0000853 name: intraflagellar_transport_abnormal synonym: "IFT_abnormal" RELATED [] is_a: WBPhenotype:0000851 ! ciliated_neuron_physiology_abnormal [Term] id: WBPhenotype:0000854 name: intraflagellar_transport_defective synonym: "ift_defective" RELATED [] is_a: WBPhenotype:0000853 ! intraflagellar_transport_abnormal [Term] id: WBPhenotype:0000855 name: pseudocoelom_development_abnormal is_a: WBPhenotype:0000200 ! pericellular_component_development_abnormal [Term] id: WBPhenotype:0000856 name: excretory_gland_cell_development_abnormal relationship: part_of WBPhenotype:0000620 ! excretory_secretory_system_development_abnormal relationship: part_of WBPhenotype:0000813 ! gland_cell_development_abnormal [Term] id: WBPhenotype:0000857 name: excretory_cell_development_abnormal synonym: "excretory_canal_cell_development_abnormal" RELATED [] relationship: part_of WBPhenotype:0000621 ! excretory_system_development_abnormal [Term] id: WBPhenotype:0000858 name: excretory_duct_cell_development_abnormal relationship: part_of WBPhenotype:0000621 ! excretory_system_development_abnormal [Term] id: WBPhenotype:0000859 name: excretory_socket_cell_development_abnormal synonym: "excretory_pore_cell_development_abnormal" RELATED [] relationship: part_of WBPhenotype:0000621 ! excretory_system_development_abnormal [Term] id: WBPhenotype:0000860 name: nonstriated_muscle_development_abnormal relationship: part_of WBPhenotype:0000622 ! muscle_system_development_abnormal [Term] id: WBPhenotype:0000861 name: body_wall_muscle_development_abnormal synonym: "somatic_muscle_development_abnormal" RELATED [] synonym: "striated_muscle_development_abnormal" RELATED [] is_a: WBPhenotype:0000921 ! striated_muscle_development_abnormal [Term] id: WBPhenotype:0000862 name: bloated is_a: WBPhenotype:0000545 ! egg_retention [Term] id: WBPhenotype:0000863 name: male_fertility_reduced is_a: WBPhenotype:0000784 ! male_fertility_abnormal [Term] id: WBPhenotype:0000864 name: early_elongation_arrest def: "Cessation of development during the early period of the conversion of the bean-shaped embryo into the two-fold- shaped embryo." [WB:WBPaper00027244] is_a: WBPhenotype:0000867 ! embryonic_arrest [Term] id: WBPhenotype:0000865 name: amphid_sheath_cell_physiology_abnormal is_a: WBPhenotype:0000849 ! amphid_physiology_abnormal [Term] id: WBPhenotype:0000866 name: germ_cell_arrest is_a: WBPhenotype:0000823 ! germline_proliferation_abnormal [Term] id: WBPhenotype:0000867 name: embryonic_arrest def: "Cessation of development during any stage occurring after fertilization and until hatching." [WB:WBPerson712] is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0000868 name: paralyzed_body def: "Body is paralyzed, but the head can move." [WB:cab] is_a: WBPhenotype:0000644 ! paralyzed [Term] id: WBPhenotype:0000869 name: mitochondria_morphology_abnormal_muscle is_obsolete: true [Term] id: WBPhenotype:0000870 name: mitochondria_morphology_abnormal_epithelial is_obsolete: true [Term] id: WBPhenotype:0000871 name: connected_mitochondria_epithelial is_obsolete: true [Term] id: WBPhenotype:0000872 name: connected_mitochodria_muscle is_obsolete: true [Term] id: WBPhenotype:0000873 name: G1_checkpoint_abnormal is_a: WBPhenotype:0000741 ! DNA_damage_checkpoint_abnormal [Term] id: WBPhenotype:0000874 name: G2_checkpoint_abnormal is_a: WBPhenotype:0000741 ! DNA_damage_checkpoint_abnormal [Term] id: WBPhenotype:0000875 name: S_phase_checkpoint_abnormal is_a: WBPhenotype:0000741 ! DNA_damage_checkpoint_abnormal [Term] id: WBPhenotype:0000876 name: organism_osmotic_stress_response_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0000877 name: amphid_sheath_cell_development_abnormal is_a: WBPhenotype:0000950 ! neuronal_sheath_cell_development_abnormal [Term] id: WBPhenotype:0000878 name: chemosensory_neuron_development_abnormal is_a: WBPhenotype:0000816 ! neuron_development_abnormal [Term] id: WBPhenotype:0000879 name: telomere_length_regulation_abnormal def: "Animals exhibit defects in the processes that are required to maintain the length of telomeric DNA from generation to generation" [GO:0032204, WB:WBPaper00031585, WB:WBPerson712] is_a: WBPhenotype:0001673 ! telomere_homeostasis_abnormal [Term] id: WBPhenotype:0000880 name: axon_development_abnormal def: "Any aberrancy in the processes that influence the generation of neuronal extensions, that carry efferent (outgoing) action potentials from the cell body towards target cells." [GO:0007409, WB:WBPerson2021] synonym: "axonogenesis_abnormal" RELATED [] is_a: WBPhenotype:0000944 ! neurite_development_abnormal [Term] id: WBPhenotype:0000881 name: cilia_mislocalized def: "Animals exhibit abnormalities in the placement of the microtuble-based dendritic projections in relation to the sensillum neuron, from that observed in normal animals." [WB:WBPerson712] is_a: WBPhenotype:0001526 ! ciliated_neuron_morphology_abnormal [Term] id: WBPhenotype:0000882 name: dendrite_development_abnormal def: "Any aberrancy in the processes that influence the generation of neuronal extensions, that carry afferent (incoming) action potentials towards the cell body." [GO:0016358, WB:WBPerson2021] is_a: WBPhenotype:0000944 ! neurite_development_abnormal [Term] id: WBPhenotype:0000883 name: nerve_ring_development_abnormal is_a: WBPhenotype:0000945 ! neuropil_development_abnormal [Term] id: WBPhenotype:0000884 name: AWB_morphology_abnormal def: "Animals exhibit abnormalities in the structure or organization of either of a set of two ciliated wing neurons, AWBL or AWBR, of the amphid sensilla, compared to that observed in normal animals. " [WB:WBbt\:0005671, WB:WBPaper00000938, WB:WBPerson712] is_a: WBPhenotype:0000256 ! amphid_morphology_abnormal [Term] id: WBPhenotype:0000885 name: engulfment_abnormal def: "Any aberrancy in the removal of a cell corpse, by a neighboring cell or a phagocyte." [GO:0043652, WB:WBPerson2021] synonym: "phagocytosis_abnormal" RELATED [] is_a: WBPhenotype:0000730 ! apoptosis_abnormal [Term] id: WBPhenotype:0000886 name: Abnormal def: "Any deviation from the norm." [WB:WBPerson557] subset: phenotype_slim_wb [Term] id: WBPhenotype:0000887 name: hermaphrodite_behavior_abnormal is_a: WBPhenotype:0000821 ! sexually_dimorphic_behavior_abnormal [Term] id: WBPhenotype:0000888 name: male_behavior_abnormal is_a: WBPhenotype:0000821 ! sexually_dimorphic_behavior_abnormal [Term] id: WBPhenotype:0000889 name: sexually_dimorphic_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000576 ! organism_physiology_abnormal [Term] id: WBPhenotype:0000890 name: larval_pigmentation_abnormal is_a: WBPhenotype:0001009 ! developmental_pigmentation_abnormal [Term] id: WBPhenotype:0000891 name: clear_adult synonym: "Clr" BROAD three_letter_name [] is_a: WBPhenotype:0000346 ! adult_pigmentation_abnormal is_a: WBPhenotype:0001010 ! clear [Term] id: WBPhenotype:0000892 name: hermaphrodite_germline_proliferation_abnormal def: "Nuclear divisions in the germ line of hermaphrodites are either expanded are reduced." [WB:WBPerson2021] synonym: "hermaphrodite_germ_cell_proliferation_abnormal" RELATED [] synonym: "hermaphrodite_germ_line_proliferation_abnormal" RELATED [] is_a: WBPhenotype:0000823 ! germline_proliferation_abnormal [Term] id: WBPhenotype:0000893 name: male_germline_proliferation_abnormal def: "Nuclear divisions in the germ line of male animals are either expanded are reduced." [WB:WBPerson2021] synonym: "male_germ_cell_proliferation_abnormal" RELATED [] synonym: "male_germ_line_proliferation_abnormal" RELATED [] is_a: WBPhenotype:0000823 ! germline_proliferation_abnormal [Term] id: WBPhenotype:0000894 name: germ_cell_differentiation_abnormal def: "Any alteration in the ability of a relatively unspecialized cell to acquire the specialized features of a mature gamete." [WB:WBPerson2021] relationship: part_of WBPhenotype:0000774 ! gametogenesis_abnormal [Term] id: WBPhenotype:0000897 name: connective_tissue_abnormal is_a: WBPhenotype:0000200 ! pericellular_component_development_abnormal [Term] id: WBPhenotype:0000898 name: blast_cell_morphology_abnormal def: "The morphological appearance of blast cells is abnormal compared to wild type." [WB:cab] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000899 name: epithelial_cell_morphology_abnormal is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000900 name: germ_cell_morphology_abnormal def: "The morphological appearance of germ cells is abnormal compared to wild type." [WB:cab] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000901 name: gland_cell_morphology_abnormal def: "The morphological appearance of gland cells is abnormal compared to wild type." [WB:cab] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000902 name: intestinal_cell_morphology_abnormal def: "The morphological appearance of intestinal cells is abnormal compared to wild type." [WB:cab] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal relationship: part_of WBPhenotype:0000710 ! intestinal_morphology_abnormal [Term] id: WBPhenotype:0000903 name: marginal_cell_morphology_abnormal def: "The morphological appearance of marginal cells is abnormal compared to wild type." [WB:cab] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000904 name: muscle_cell_morphology_abnormal def: "The morphological appearance of muscle cells is abnormal compared to wild type." [WB:cab] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000905 name: neuron_morphology_abnormal def: "Animals display deviations in the structure or organization of components of the neuronal cell internal to the cell itself or in relation to the cellular environment. A neuron is a major cell type of nervous tissue specialized for transmission of information in the form of patterns of impulses, compared to that observed in normal animals. " [WB:cab, WB:WBbt\:0003679, WB:WBPerson712] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal relationship: part_of WBPhenotype:0000604 ! nervous_system_morphology_abnormal [Term] id: WBPhenotype:0000906 name: uterine_vulval_cell_morphology_abnormal is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0000907 name: anus_morphology_abnormal relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_abnormal [Term] id: WBPhenotype:0000908 name: cloacal_morphology_abnormal alt_id: WBPhenotype:0000343 synonym: "cloaca_morphology_abnormal" EXACT [] relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_abnormal relationship: part_of WBPhenotype:0000605 ! reproductive_system_morphology_abnormal [Term] id: WBPhenotype:0000909 name: pharyngeal_intestinal_valve_morphology_abnormal is_a: WBPhenotype:0000598 ! alimentary_system_morphology_abnormal [Term] id: WBPhenotype:0000910 name: rectal_morphology_abnormal relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_abnormal [Term] id: WBPhenotype:0000911 name: coelomocyte_morphology_abnormal relationship: part_of WBPhenotype:0000599 ! coelomic_system_morphology_abnormal [Term] id: WBPhenotype:0000912 name: pericellular_component_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000520 ! morphology_abnormal [Term] id: WBPhenotype:0000913 name: basal_lamina_morphology_abnormal relationship: part_of WBPhenotype:0000600 ! epithelial_system_morphology_abnormal [Term] id: WBPhenotype:0000914 name: excretory_gland_cell_morphology_abnormal relationship: part_of WBPhenotype:0000601 ! excretory_secretory_system_morphology_abnormal [Term] id: WBPhenotype:0000915 name: pale_adult is_a: WBPhenotype:0000346 ! adult_pigmentation_abnormal is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000916 name: excretory_cell_morphology_abnormal synonym: "excretory_canal_cell_morphology_abnormal" RELATED [] relationship: part_of WBPhenotype:0000602 ! excretory_system_morphology_abnormal [Term] id: WBPhenotype:0000917 name: excretory_duct_cell_morphology_abnormal relationship: part_of WBPhenotype:0000602 ! excretory_system_morphology_abnormal [Term] id: WBPhenotype:0000918 name: excretory_socket_cell_morphology_abnormal relationship: part_of WBPhenotype:0000602 ! excretory_system_morphology_abnormal [Term] id: WBPhenotype:0000919 name: spindle_body_wall_muscle_cell_development_abnormal synonym: "filament_lattice_body_wall_muscle_cell_development_abnormal" RELATED [] is_a: WBPhenotype:0000087 ! body_wall_cell_development_abnormal [Term] id: WBPhenotype:0000920 name: body_wall_muscle_cell_development_abnormal synonym: "muscle_belly_development_abnormal" RELATED [] is_obsolete: true [Term] id: WBPhenotype:0000921 name: striated_muscle_development_abnormal relationship: part_of WBPhenotype:0000622 ! muscle_system_development_abnormal [Term] id: WBPhenotype:0000922 name: male_longitudinal_muscle_development_abnormal is_a: WBPhenotype:0000921 ! striated_muscle_development_abnormal [Term] id: WBPhenotype:0000923 name: nonstriated_muscle_morphology_abnormal relationship: part_of WBPhenotype:0000603 ! muscle_system_morphology_abnormal [Term] id: WBPhenotype:0000924 name: striated_muscle_morphology_abnormal relationship: part_of WBPhenotype:0000603 ! muscle_system_morphology_abnormal [Term] id: WBPhenotype:0000925 name: sex_muscle_morphology_abnormal is_a: WBPhenotype:0000923 ! nonstriated_muscle_morphology_abnormal [Term] id: WBPhenotype:0000926 name: body_wall_muscle_morphology_abnormal relationship: part_of WBPhenotype:0000924 ! striated_muscle_morphology_abnormal [Term] id: WBPhenotype:0000927 name: male_longitudinal_muscle_morphology_abnormal relationship: part_of WBPhenotype:0000924 ! striated_muscle_morphology_abnormal [Term] id: WBPhenotype:0000928 name: male_physiology_abnormal is_a: WBPhenotype:0000889 ! sexually_dimorphic_physiology_abnormal [Term] id: WBPhenotype:0000929 name: hermaphrodite_physiology_abnormal is_a: WBPhenotype:0000889 ! sexually_dimorphic_physiology_abnormal [Term] id: WBPhenotype:0000930 name: sexually_dimorphic_development_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000531 ! organism_development_abnormal [Term] id: WBPhenotype:0000931 name: bis_phenol_A_response_abnormal is_a: WBPhenotype:0000523 ! chemical_response_abnormal [Term] id: WBPhenotype:0000932 name: bis_phenol_A_hypersensitive is_a: WBPhenotype:0000931 ! bis_phenol_A_response_abnormal [Term] id: WBPhenotype:0000933 name: MS_lineage_abnormal def: "The descendants of the MS blastomere exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPaper00002330, WB:WBPerson2021] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000934 name: developmental_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000535 ! organism_morphology_abnormal [Term] id: WBPhenotype:0000935 name: D_lineage_abnormal def: "The descendants of the D blastomere exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPaper00002572, WB:WBPerson2021] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000936 name: P4_lineage_abnormal def: "The descendants of the P4 blastomere exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000937 name: W_lineage_abnormal def: "The descendants of the W precursor cell exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_abnormal [Term] id: WBPhenotype:0000938 name: male_V_lineages_abnormal def: "The descendants of any of the V precursor cells (V1-V6) in male animals, exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000809 ! male_specific_lineage_abnormal [Term] id: WBPhenotype:0000939 name: male_T_lineages_abnormal def: "The descendants of TL or TR cells in male animals exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000809 ! male_specific_lineage_abnormal [Term] id: WBPhenotype:0000940 name: male_P_lineages_abnormal def: "The descendants of any of the P precursor cells (P1-P12) in male animals exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000809 ! male_specific_lineage_abnormal [Term] id: WBPhenotype:0000941 name: male_M_lineage_abnormal def: "The descendants of the M precursor cell in male animals, exhibit altered developmental programs compared to their counterparts in normal animals." [WB:WBPerson2021] is_a: WBPhenotype:0000809 ! male_specific_lineage_abnormal [Term] id: WBPhenotype:0000942 name: accessory_cell_development_abnormal relationship: part_of WBPhenotype:0000623 ! nervous_system_development_abnormal [Term] id: WBPhenotype:0000943 name: ganglion_development_abnormal relationship: part_of WBPhenotype:0000623 ! nervous_system_development_abnormal [Term] id: WBPhenotype:0000944 name: neurite_development_abnormal def: "Any alteration in the progression of a neuronal extension (such as axons or dendrites) over time, from its formation to the mature structure." [GO:0031175, WB:WBPerson2021] is_a: WBPhenotype:0000816 ! neuron_development_abnormal [Term] id: WBPhenotype:0000945 name: neuropil_development_abnormal relationship: part_of WBPhenotype:0000623 ! nervous_system_development_abnormal [Term] id: WBPhenotype:0000946 name: pharyngeal_nervous_system_development_abnormal relationship: part_of WBPhenotype:0000623 ! nervous_system_development_abnormal [Term] id: WBPhenotype:0000947 name: connective_tissue_morphology_abnormal is_a: WBPhenotype:0000912 ! pericellular_component_morphology_abnormal [Term] id: WBPhenotype:0000948 name: cuticle_morphology_abnormal is_a: WBPhenotype:0000912 ! pericellular_component_morphology_abnormal [Term] id: WBPhenotype:0000949 name: pseudocoelom_morphology_abnormal def: "Body cavity appearance is not normal, often exhibiting an accumulation of fluids or fluorescent reporters. " [WB:WBPerson712] is_a: WBPhenotype:0000912 ! pericellular_component_morphology_abnormal [Term] id: WBPhenotype:0000950 name: neuronal_sheath_cell_development_abnormal is_a: WBPhenotype:0000942 ! accessory_cell_development_abnormal [Term] id: WBPhenotype:0000951 name: socket_cell_development_abnormal is_a: WBPhenotype:0000942 ! accessory_cell_development_abnormal [Term] id: WBPhenotype:0000952 name: anterior_ganglion_development_abnormal is_a: WBPhenotype:0000943 ! ganglion_development_abnormal [Term] id: WBPhenotype:0000953 name: dorsal_ganglion_development_abnormal is_a: WBPhenotype:0000943 ! ganglion_development_abnormal [Term] id: WBPhenotype:0000954 name: dorsorectal_ganglia_development_abnormal is_a: WBPhenotype:0000943 ! ganglion_development_abnormal [Term] id: WBPhenotype:0000955 name: lateral_ganglia_development_abnormal is_a: WBPhenotype:0000943 ! ganglion_development_abnormal [Term] id: WBPhenotype:0000956 name: lumbar_ganglia_development_abnormal is_a: WBPhenotype:0000943 ! ganglion_development_abnormal [Term] id: WBPhenotype:0000957 name: posterior_lateral_ganglion_development_abnormal is_a: WBPhenotype:0000943 ! ganglion_development_abnormal [Term] id: WBPhenotype:0000958 name: preanal_ganglion_development_abnormal is_a: WBPhenotype:0000943 ! ganglion_development_abnormal [Term] id: WBPhenotype:0000959 name: retrovesicular_ganglion_development_abnormal is_a: WBPhenotype:0000943 ! ganglion_development_abnormal [Term] id: WBPhenotype:0000960 name: ventral_ganglion_development_abnormal is_a: WBPhenotype:0000943 ! ganglion_development_abnormal [Term] id: WBPhenotype:0000961 name: pattern_of_transgene_expression_abnormal def: "Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in normal animals." [WB:WBPerson557] is_a: WBPhenotype:0000306 ! transgene_expression_abnormal [Term] id: WBPhenotype:0000962 name: level_of_transgene_expression_abnormal def: "Any variation in the measurment of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in normal animals." [WB:WBPerson557] is_a: WBPhenotype:0000306 ! transgene_expression_abnormal [Term] id: WBPhenotype:0000963 name: male_pigmentation_abnormal is_a: WBPhenotype:0000527 ! organism_pigmentation_abnormal [Term] id: WBPhenotype:0000964 name: DMPP_resistant is_a: WBPhenotype:0000681 ! DMPP_response_abnormal [Term] id: WBPhenotype:0000965 name: somatic_cell_death_abnormal is_a: WBPhenotype:0001172 ! programmed_cell_death_abnormal [Term] id: WBPhenotype:0000966 name: germline_mortal def: "progressive decrease in brood size culminating, over generations, in the loss of reproductive ability and thus becoming effectively sterile." [WB:WBPaper00003886, WB:WBPaper00027026, WB:WBPerson712] synonym: "Mrt" BROAD three_letter_name [] is_a: WBPhenotype:0000987 ! germ_cell_physiology_abnormal [Term] id: WBPhenotype:0000967 name: male_tail_spike is_a: WBPhenotype:0000070 ! male_tail_morphology_abnormal [Term] id: WBPhenotype:0000968 name: tail_spike is_a: WBPhenotype:0000073 ! tail_morphology_abnormal [Term] id: WBPhenotype:0000969 name: accessory_cell_morphology_abnormal def: "Animals exhibit deviations in the structure, organization or placement of the cells that support sensory neurons, This category collectively refers to socket cells, sheath cells, and structural cells, or their processes,compared to that observed in normal animals." [WB:WBbt\:0005762, WB:WBPerson712] relationship: part_of WBPhenotype:0000604 ! nervous_system_morphology_abnormal [Term] id: WBPhenotype:0000970 name: embryonic_pigmentation_abnormal is_a: WBPhenotype:0001009 ! developmental_pigmentation_abnormal [Term] id: WBPhenotype:0000971 name: anterior_pigmentation_abnormal is_a: WBPhenotype:0000786 ! body_axis_pigmentation_abnormal [Term] id: WBPhenotype:0000972 name: neuronal_sheath_cell_morphology_abnormal def: "Animals exhibit deviations in the structure or composition of the glia-like support cell of neuronal sensilla that ensheathes the dendrite tips and or processes of neurons, from that observed in normal animals. Sheath cells in normal animals have highly invaginated and vesiculated surfaces, which provide a specialized environment for dendritic structures." [WB:WBPaper00000822, WB:WBPaper00000938, WB:WBPerson712] is_a: WBPhenotype:0000969 ! accessory_cell_morphology_abnormal [Term] id: WBPhenotype:0000973 name: homologous_recombination_increased is_a: WBPhenotype:0000742 ! DNA_recombination_abnormal [Term] id: WBPhenotype:0000974 name: accessory_cell_physiology_abnormal relationship: part_of WBPhenotype:0000612 ! nervous_system_physiology_abnormal [Term] id: WBPhenotype:0000975 name: neuronal_sheath_cell_physiology_abnormal is_a: WBPhenotype:0000974 ! accessory_cell_physiology_abnormal [Term] id: WBPhenotype:0000976 name: ventral_cord_patterning_abnormal is_a: WBPhenotype:0000515 ! ventral_nerve_cord_development_abnormal [Term] id: WBPhenotype:0000977 name: somatic_gonad_morphology_abnormal relationship: part_of WBPhenotype:0001355 ! gonad_morphology_abnormal [Term] id: WBPhenotype:0000978 name: spermatheca_physiology_abnormal is_a: WBPhenotype:0001197 ! somatic_gonad_physiology_abnormal [Term] id: WBPhenotype:0000979 name: spermatheca_dilation_defective is_a: WBPhenotype:0000978 ! spermatheca_physiology_abnormal [Term] id: WBPhenotype:0000980 name: pharyngeal_contraction_abnormal is_a: WBPhenotype:0000634 ! pharyngeal_pumping_abnormal [Term] id: WBPhenotype:0000981 name: spermatocyte_meiosis_abnormal def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids (non-motile sperm) are altered." [GO:0048137, WB:WBPaper00027300, WB:WBPaper00031282, WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis_abnormal [Term] id: WBPhenotype:0000982 name: spermatid_maturation_abnormal def: "Any alteration in the ability of a relatively unspecialized spermatocyte to acquire the properties of a spermatid cell (non-motile sperm)." [WB:WBPaper00027300, WB:WBPaper00031282, WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis_abnormal [Term] id: WBPhenotype:0000983 name: fertilization_defective is_a: WBPhenotype:0000613 ! reproductive_system_physiology_abnormal [Term] id: WBPhenotype:0000984 name: posterior_pigmentation_abnormal is_a: WBPhenotype:0000786 ! body_axis_pigmentation_abnormal [Term] id: WBPhenotype:0000985 name: blast_cell_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000986 name: epithelial_cell_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000987 name: germ_cell_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000988 name: gland_cell_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000989 name: marginal_cell_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000990 name: muscle_cell_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000991 name: neuron_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0000992 name: high_sodium_chloride_concentration_osmotic_avoidance_defective def: "Failure to execute the characteristic avoidance response to high concentrations of sodium chloride solution." [WB:WBPerson2021] is_a: WBPhenotype:0001453 ! high_sodium_chloride_concentration_osmotic_avoidance_abnormal [Term] id: WBPhenotype:0000993 name: anal_depressor_contraction_defect def: "failure in the ability of the anal depressor muscle to contract fully." [WB:WBPaper00001256] synonym: "Exp" BROAD three_letter_name [] is_a: WBPhenotype:0001092 ! larval_defecation_defect [Term] id: WBPhenotype:0000994 name: intestinal_contractions_abnormal is_a: WBPhenotype:0000650 ! defecation_abnormal [Term] id: WBPhenotype:0000996 name: expulsion_defective def: "Defects in the enteric muscle contractions leading to expulsion of gut contents during the defecation cycle. This step consists of the intestinal muscle and anal depressor contractions that further pressurize intestinal contents and open the anus to permit expulsion." [WB:WBPaper00001256, WB:WBPaper00031246, WB:WBPerson712] synonym: "Emc" BROAD three_letter_name [] synonym: "Exp" BROAD three_letter_name [] is_a: WBPhenotype:0000205 ! expulsion_abnormal [Term] id: WBPhenotype:0000997 name: cryophilic is_a: WBPhenotype:0000478 ! isothermal_tracking_behavior_abnormal [Term] id: WBPhenotype:0000998 name: thermophilic is_a: WBPhenotype:0000478 ! isothermal_tracking_behavior_abnormal [Term] id: WBPhenotype:0000999 name: athermotactic is_a: WBPhenotype:0000478 ! isothermal_tracking_behavior_abnormal [Term] id: WBPhenotype:0001000 name: developmental_behavior_abnormal def: "Behavior characteristic during certain developmental stage(s) is altered." [WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0001001 name: dauer_behavior_abnormal is_a: WBPhenotype:0000819 ! postembryonic_behavior_abnormal [Term] id: WBPhenotype:0001002 name: head_muscle_behavior_abnormal is_a: WBPhenotype:0000595 ! head_behavior_abnormal [Term] id: WBPhenotype:0001003 name: L4_lethal def: "Animals die at the L4 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000058 ! late_larval_lethal [Term] id: WBPhenotype:0001004 name: pharyngeal_relaxation_abnormal is_a: WBPhenotype:0000634 ! pharyngeal_pumping_abnormal [Term] id: WBPhenotype:0001005 name: backward_locomotion_abnormal is_a: WBPhenotype:0004017 ! locomotor_coordination_abnormal [Term] id: WBPhenotype:0001006 name: pharyngeal_pumping_rate_abnormal is_a: WBPhenotype:0000634 ! pharyngeal_pumping_abnormal [Term] id: WBPhenotype:0001007 name: other_abnormality_early_emb def: "Unclassified abnormality in the inviable one- to four-cell embryo." [WB:cab] synonym: "Emb" BROAD three_letter_name [] synonym: "Oth" RELATED [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001008 name: male_nervous_system_development_abnormal relationship: part_of WBPhenotype:0000623 ! nervous_system_development_abnormal [Term] id: WBPhenotype:0001009 name: developmental_pigmentation_abnormal is_a: WBPhenotype:0000527 ! organism_pigmentation_abnormal [Term] id: WBPhenotype:0001010 name: clear def: "At least 10% of worms appear unusually transparent when compared to wild-type." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654] synonym: "Clr" BROAD three_letter_name [] is_a: WBPhenotype:0000527 ! organism_pigmentation_abnormal [Term] id: WBPhenotype:0001011 name: complex_phenotype_early_emb def: "Complex combination of defects that does not match other class definitions." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001007 ! other_abnormality_early_emb [Term] id: WBPhenotype:0001012 name: organism_pathogen_response_abnormal is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_abnormal [Term] id: WBPhenotype:0001013 name: pathogen_susceptibility_increased def: "Susceptibility to infection by pathogens is increased." [WB:cab, WB:WBPaper00005370, WB:WBPaper00024299] synonym: "enhanced_susceptibility_to_pathogens" RELATED [] synonym: "Esp" BROAD three_letter_name [] is_a: WBPhenotype:0001012 ! organism_pathogen_response_abnormal [Term] id: WBPhenotype:0001014 name: pathogen_resistance_increased is_a: WBPhenotype:0001012 ! organism_pathogen_response_abnormal [Term] id: WBPhenotype:0001015 name: developmental_growth_abnormal is_a: WBPhenotype:0000030 ! growth_abnormal [Term] id: WBPhenotype:0001016 name: larval_growth_abnormal is_a: WBPhenotype:0001015 ! developmental_growth_abnormal [Term] id: WBPhenotype:0001017 name: adult_growth_abnormal is_a: WBPhenotype:0001015 ! developmental_growth_abnormal [Term] id: WBPhenotype:0001018 name: cytokinesis_abnormal_emb synonym: "Cyk" BROAD three_letter_name [] is_a: WBPhenotype:0000050 ! embryonic_lethal is_a: WBPhenotype:0000746 ! cell_division_abnormal [Term] id: WBPhenotype:0001019 name: mid_larval_arrest def: "Larval arrest during the L2 to L3 stages of larval development." [WB:cab] is_a: WBPhenotype:0000059 ! larval_arrest [Term] id: WBPhenotype:0001020 name: embryonic_lethal_late_emb def: "Animal dies during the last (3-fold) stage of embryogenesis, which normally occurs 620-800 min after the first cleavage at 20C, the stage after elongation." [WB:WBPerson101] synonym: "Emb" BROAD three_letter_name [] synonym: "Led" RELATED [] is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0001021 name: male_sexual_development_abnormal def: "XO animals are transformed into fertile hermaphrodites." [WB:WBPaper00000498, WB:WBPerson2021] synonym: "Her" BROAD three_letter_name [] is_a: WBPhenotype:0000822 ! sex_determination_abnormal [Term] id: WBPhenotype:0001022 name: hermaphrodite_sexual_development_abnormal def: "XX animals develop as males or intersexuals instead of self-fertile hermaphrodites." [WB:WBPerson2021] is_a: WBPhenotype:0000822 ! sex_determination_abnormal [Term] id: WBPhenotype:0001023 name: sexually_dimorphic_morphology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000535 ! organism_morphology_abnormal [Term] id: WBPhenotype:0001024 name: male_morphology_abnormal is_a: WBPhenotype:0001023 ! sexually_dimorphic_morphology_abnormal [Term] id: WBPhenotype:0001025 name: hermaphrodite_morphology_abnormal is_a: WBPhenotype:0001023 ! sexually_dimorphic_morphology_abnormal [Term] id: WBPhenotype:0001026 name: nuclear_morphology_alteration_early_emb synonym: "Emb" BROAD [] synonym: "Nmo" BROAD three_letter_name [] is_a: WBPhenotype:0001035 ! nuclear_appearance_number_abnormal_early_emb [Term] id: WBPhenotype:0001027 name: nuclear_position_abnormal_early_emb synonym: "Emb" BROAD [] synonym: "Npo" BROAD three_letter_name [] is_a: WBPhenotype:0001138 ! nucleus_abnormal_early_emb [Term] id: WBPhenotype:0001028 name: nuclear_appearance_abnormal def: "The morphological appearance of nuclei differs from wild type." [WB:cab] subset: phenotype_slim_wb is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0001029 name: patchy_coloration synonym: "Pch" BROAD three_letter_name [] is_a: WBPhenotype:0000527 ! organism_pigmentation_abnormal [Term] id: WBPhenotype:0001030 name: pronuclear_envelope_abnormal_early_emb synonym: "Emb" BROAD [] synonym: "Pna" BROAD three_letter_name [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_abnormal_early_emb [Term] id: WBPhenotype:0001031 name: pronuclear_migration_reduced_early_emb def: "Lack of male pronuclear migration, female pronuclear migration variable, sometimes multiple female pronuclei, no or small spindle." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001152 ! pronuclear_migration_abnormal_early_emb [Term] id: WBPhenotype:0001032 name: larval_behavior_abnormal is_a: WBPhenotype:0000819 ! postembryonic_behavior_abnormal [Term] id: WBPhenotype:0001033 name: proximal_germ_cell_proliferation_abnormal def: "An ectopic mass of proliferating germ cells occupies the proximal adult germ line, a region normally occupied by gametes. As a result, the normal spatial pattern of proliferation and differentiation in the germ line is disrupted." [WB:WBPaper00006484, WB:WBPerson2021] synonym: "Pro" BROAD three_letter_name [] is_a: WBPhenotype:0001215 ! germ_cell_mitosis_abnormal [Term] id: WBPhenotype:0001034 name: pronuclear_nuclear_appearance_abnormal_early_emb def: "Pronuclei and nuclei are small or missing altogether, often accompanied by spindle defects." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal is_a: WBPhenotype:0001374 ! pronuclear_nuclear_appearance_abnormal_emb [Term] id: WBPhenotype:0001035 name: nuclear_appearance_number_abnormal_early_emb def: "Pronuclei are normal but nuclei are completely missing or significantly smaller than normal; often accompanied by spindle and cytokinesis defects." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] synonym: "nucleus_abnormal_emb" RELATED [] is_a: WBPhenotype:0000770 ! embryonic_cell_morphology_abnormal is_a: WBPhenotype:0001138 ! nucleus_abnormal_early_emb [Term] id: WBPhenotype:0001036 name: sterile_F1 is_a: WBPhenotype:0001037 ! sterile_progeny [Term] id: WBPhenotype:0001037 name: sterile_progeny synonym: "Stp" BROAD three_letter_name [] is_a: WBPhenotype:0000069 ! progeny_abnormal is_a: WBPhenotype:0000688 ! sterile [Term] id: WBPhenotype:0001038 name: tumorous_germline def: "Germ cells do not exit the mitotic cycle, resulting in a huge expansion of the unspecialized germ cell population." [WB:WBPaper00002730, WB:WBPerson2021] synonym: "Tum" BROAD three_letter_name [] synonym: "tumorous_germ_line" EXACT [] is_a: WBPhenotype:0000812 ! germ_cell_development_abnormal [Term] id: WBPhenotype:0001039 name: embryonic_growth_abnormal is_a: WBPhenotype:0001015 ! developmental_growth_abnormal [Term] id: WBPhenotype:0001040 name: chemosensory_response_abnormal def: "Typical response to chemicals is altered." [WB:cab, WB:cgc3824] is_a: WBPhenotype:0000523 ! chemical_response_abnormal is_a: WBPhenotype:0001049 ! chemosensory_behavior_abnormal [Term] id: WBPhenotype:0001041 name: meiosis_abnormal_early_emb synonym: "Emb" BROAD [] synonym: "Mei" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001042 name: neuron_function_reduced is_a: WBPhenotype:0000991 ! neuron_physiology_abnormal [Term] id: WBPhenotype:0001043 name: interphase_entry_abnormal_early_emb def: "Embryos spend longer than normal when entering first interphase." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000740 ! cell_cycle_abnormal is_a: WBPhenotype:0000775 ! meiosis_abnormal is_a: WBPhenotype:0001041 ! meiosis_abnormal_early_emb [Term] id: WBPhenotype:0001044 name: cortical_dynamics_abnormal_early_emb def: "Little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity at the two-cell stage." [WB:cab, WB:cgc7141] synonym: "Cpa" BROAD [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000764 ! embryonic_cell_organization_biogenesis_abnormal is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001045 name: sporadic_pumping def: "Pharyngeal pumping contractions are brief and occur occasionally." [WB:WBPaper00001709] is_a: WBPhenotype:0000019 ! pharyngeal_pumping_reduced [Term] id: WBPhenotype:0001046 name: pharyngeal_muscle_morphology_abnormal def: "Any abnormalities associated with the characteristic morphology of the pharyngeal muscle such as shape, birefringence etc." [WB:WBPaper00001709] relationship: part_of WBPhenotype:0000923 ! nonstriated_muscle_morphology_abnormal [Term] id: WBPhenotype:0001047 name: aqueous_positive_chemotaxis_abnormal def: "Movement towards typically attractive water-soluble chemicals is altered." [WB:cab, WB:cgc3824] synonym: "water_soluble_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000635 ! positive_chemotaxis_abnormal is_a: WBPhenotype:0001443 ! aqueous_chemosensory_response_abnormal [Term] id: WBPhenotype:0001048 name: odorant_chemosensory_response_abnormal def: "Chemosensory response to volatile organic compounds is altered." [WB:WBPerson2021] synonym: "volatile_chemosensory_response_abnormal" RELATED [] is_a: WBPhenotype:0001040 ! chemosensory_response_abnormal [Term] id: WBPhenotype:0001049 name: chemosensory_behavior_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0001050 name: chemosensation_abnormal is_a: WBPhenotype:0001049 ! chemosensory_behavior_abnormal [Term] id: WBPhenotype:0001051 name: cation_positive_chemotaxis_abnormal def: "Characteristic movement towards typically attractive cations is altered." [WB:cab, WB:cgc387, WB:WBPaper00000387] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001052 name: anion_positive_chemotaxis_abnormal def: "Characteristic movement towards typically attractive anions is altered." [WB:cab, WB:cgc387, WB:WBPaper00000387] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001053 name: cyclic_nucleotide_positive_chemotaxis_abnormal def: "Characteristic movement towards cyclic nucleotides is altered." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001054 name: cGMP_chemotaxis_defective def: "Failure to move towards cGMP." [WB:cab, WB:cgc387, WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001464 ! cGMP_chemotaxis_abnormal [Term] id: WBPhenotype:0001055 name: bromide_chemotaxis_defective def: "Failure to move towards bromide." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001439 ! anion_positive_chemotaxis_defective is_a: WBPhenotype:0001457 ! bromide_chemotaxis_abnormal [Term] id: WBPhenotype:0001056 name: iodide_chemotaxis_defective def: "Failure to move towards iodide." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001439 ! anion_positive_chemotaxis_defective is_a: WBPhenotype:0001459 ! iodide_chemotaxis_abnormal [Term] id: WBPhenotype:0001057 name: lithium_chemotaxis_defective def: "Failure to move towards lithium." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001440 ! cation_positive_chemotaxis_defective [Term] id: WBPhenotype:0001058 name: potassium_chemotaxis_defective def: "Failure of the animals to move towards potassium." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001440 ! cation_positive_chemotaxis_defective [Term] id: WBPhenotype:0001059 name: magnesium_chemotaxis_defective def: "Failure to move towards magnesium." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001440 ! cation_positive_chemotaxis_defective [Term] id: WBPhenotype:0001060 name: AWC_odorant_chemotaxis_defective def: "Failure to move towards typically attractive volatile organic molecules sensed by the AWC." [WB:WBPerson2021] synonym: "AWC_volatile_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective [Term] id: WBPhenotype:0001061 name: AWA_odorant_chemotaxis_defective def: "Failure to move towards typically attractive volatile organic molecules sensed by the AWA." [WB:WBPerson2021] synonym: "AWA_volatile_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective [Term] id: WBPhenotype:0001062 name: late_paralysis_arrested_elongation_two_fold def: "Movement and elongation stop nearly simultaneously soon after the twofold stage of elongation. However, mutant embryos twitch at the one-and-a-half-fold stage of elongation, like wild type, and move as well as wild type at the two- fold stage. " [WB:cab, WB:cgc1894] is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0001063 name: egg_laying_phases_abnormal def: "Fluctuation between inactive, active, and egg-laying states is atypical, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab] is_a: WBPhenotype:0000272 ! egg_laying_irregular [Term] id: WBPhenotype:0001064 name: inactive_phase_long def: "Animals display uncharacteristically long periods during which they do not lay eggs, as in HSN-ablated and serotonin-deficient animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab] is_a: WBPhenotype:0000006 ! egg_laying_defective is_a: WBPhenotype:0001066 ! inactive_phase_abnormal [Term] id: WBPhenotype:0001065 name: fewer_egg_laying_events_during_active def: "Fewer egg-laying events occur within the active phase of egg laying, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] is_a: WBPhenotype:0000006 ! egg_laying_defective is_a: WBPhenotype:0001067 ! active_phase_abnormal [Term] id: WBPhenotype:0001066 name: inactive_phase_abnormal def: "The period during which the animal is less likely to lay eggs is not typical compared with wild type, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab] is_a: WBPhenotype:0001063 ! egg_laying_phases_abnormal [Term] id: WBPhenotype:0001067 name: active_phase_abnormal def: "The active phase of egg-laying, the period during which animals are more likely to display multiple egg-laying events, is atypical compared with wild-type animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] is_a: WBPhenotype:0001063 ! egg_laying_phases_abnormal [Term] id: WBPhenotype:0001068 name: egg_laying_serotonin_resistant def: "Animals are not induced to lay eggs in reponse to exogenous serotonin. Serotonin stimulates egg-laying in normal animals. " [WB:WBPaper00000635, WB:WBPaper00031293, WB:WBPerson712] is_a: WBPhenotype:0000024 ! serotonin_resistant is_a: WBPhenotype:0001629 ! egg_laying_serotonin_abnormal [Term] id: WBPhenotype:0001069 name: increased_egg_laying_events_during_active def: "More eggs are laid during the active phase compared with wild type, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] is_a: WBPhenotype:0001067 ! active_phase_abnormal [Term] id: WBPhenotype:0001070 name: inactive_phase_short def: "The period during which a worm usually does not lay eggs is short compared with wild type, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] is_a: WBPhenotype:0001066 ! inactive_phase_abnormal [Term] id: WBPhenotype:0001071 name: active_phase_switch_defective def: "Activation of the active phase of egg laying is defective, leading to an abnormally long inactive phase, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab] is_a: WBPhenotype:0001064 ! inactive_phase_long [Term] id: WBPhenotype:0001072 name: response_to_food_abnormal is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_abnormal [Term] id: WBPhenotype:0001073 name: egg_laying_response_to_food_abnormal def: "Well-fed animals do not lay more eggs compared with starved animals, unlike wild type." [pmid:10757762, WB:cab] is_a: WBPhenotype:0000640 ! egg_laying_abnormal is_a: WBPhenotype:0001072 ! response_to_food_abnormal [Term] id: WBPhenotype:0001074 name: vulval_muscle_unresponsive_to_serotonin def: "The vulval muscle does not respond typically to serotonin, based on imaging of calcium transients in response to serotonin." [pmid:14588249, WB:cab] is_a: WBPhenotype:0001068 ! egg_laying_serotonin_resistant is_a: WBPhenotype:0001076 ! vulval_muscle_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0001075 name: vulval_muscle_physiology_abnormal relationship: part_of WBPhenotype:0000613 ! reproductive_system_physiology_abnormal [Term] id: WBPhenotype:0001076 name: vulval_muscle_homeostasis_metabolism_abnormal is_a: WBPhenotype:0001075 ! vulval_muscle_physiology_abnormal [Term] id: WBPhenotype:0001077 name: chromosome_segregation_abnormal_karyomeres_early_emb def: "Karyomeres in AB or P1 often accompanied by weak/thin wobbly spindle." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000773 ! chromosome_segregation_abnormal is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001078 name: cytokinesis_abnormal_early_emb def: "Cytokinesis is abnormal in the first or second stages of cell division." [WB:cab, WB:cgc7141] synonym: "Cyk" BROAD three_letter_name [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001018 ! cytokinesis_abnormal_emb is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001079 name: cytoplasmic_dynamics_abnormal_early_emb def: "Cytoplasmic movements are atypical." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000769 ! cytoplasmic_appearance_abnormal_early_emb [Term] id: WBPhenotype:0001080 name: excessive_blebbing_early_emb def: "Excessive shaking and movements are seen in the cell membrane or cytoplasm of one-cell or two-cell embryos." [cgc:5599, WB:cab] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001079 ! cytoplasmic_dynamics_abnormal_early_emb [Term] id: WBPhenotype:0001081 name: cytoplasmic_morphology_abnormal_early_emb def: "Morphology of the cytoplasm differs from wild type." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000769 ! cytoplasmic_appearance_abnormal_early_emb [Term] id: WBPhenotype:0001082 name: large_cytoplasmic_granules_early_emb def: "Abnormally large granules are observed in the cytoplasm of P0." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001081 ! cytoplasmic_morphology_abnormal_early_emb [Term] id: WBPhenotype:0001083 name: multiple_cytoplasmic_cavities_early_emb def: "Multiple vesicles, vacuoles, or cavities are seen during early embryogenesis." [cgc:5599, WB:cab] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001081 ! cytoplasmic_morphology_abnormal_early_emb [Term] id: WBPhenotype:0001084 name: sodium_chloride_chemotaxis_defective alt_id: WBPhenotype:0000995 def: "Failure to move towards attractive concentrations of sodium chloride." [WB:WBPaper00000119] synonym: "NaCl_chemotaxis_defective" EXACT [] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001462 ! sodium_chloride_chemotaxis_abnormal [Term] id: WBPhenotype:0001085 name: butanone_chemotaxis_defective def: "Failure to move towards typically attractive concentrations of butanone." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001469 ! butanone_chemotaxis_abnormal [Term] id: WBPhenotype:0001086 name: trimethylthiazole_chemotaxis_defective def: "Failure to move towards typically attractive concentrations of trimethylthiazole." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001475 ! trimethylthiazole_chemotaxis_abnormal [Term] id: WBPhenotype:0001087 name: acetone_chemotaxis_defective def: "Failure to move towards typically attractive concentrations of acetone." [WB:WBPaper00024240] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001465 ! acetone_chemotaxis_abnormal [Term] id: WBPhenotype:0001088 name: pentanol_chemotaxis_defective def: "Failure to move towards typically attractive concentrations of pentanol." [WB:WBPerson2021] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001473 ! pentanol_chemotaxis_abnormal [Term] id: WBPhenotype:0001089 name: hexanol_chemotaxis_defective def: "Failure to move towards typically attractive concentrations of hexanol." [WB:WBPerson2021] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001471 ! hexanol_chemotaxis_abnormal [Term] id: WBPhenotype:0001090 name: thermotolerance_reduced is_a: WBPhenotype:0000146 ! organism_temperature_response_abnormal [Term] id: WBPhenotype:0001091 name: larval_defecation_abnormal is_a: WBPhenotype:0000650 ! defecation_abnormal [Term] id: WBPhenotype:0001092 name: larval_defecation_defect is_a: WBPhenotype:0001091 ! larval_defecation_abnormal [Term] id: WBPhenotype:0001093 name: intestinal_physiology_abnormal relationship: part_of WBPhenotype:0000606 ! alimentary_system_physiology_abnormal [Term] id: WBPhenotype:0001094 name: NaCl_response_abnormal def: "Organismal response to NaCl differs from wild type." [WB:cab] is_obsolete: true [Term] id: WBPhenotype:0001095 name: organism_high_sodium_chloride_hypersensitive def: "Generation time and number of progeny are reduced in response to growth on media containing high NaCl." [pmid:16027367, WB:cab] is_a: WBPhenotype:0000876 ! organism_osmotic_stress_response_abnormal [Term] id: WBPhenotype:0001096 name: protrusion_at_vulval_region def: "Large protrusion at the normal position of the vulva, as seen in lin-12 null animals." [cgc:646, WB:cab] synonym: "ventral_protrusion" NARROW [] is_a: WBPhenotype:0000695 ! vulva_morphology_abnormal [Term] id: WBPhenotype:0001097 name: premature_spermatocyte_germ_cell_differentiation def: "Unspecialized male germ cells (spermatocytes) prematurely acquire the specialized properties of functional sperm." [cgc:4207, WB:cab, WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis_abnormal [Term] id: WBPhenotype:0001098 name: no_rectum def: "Animals lack the passage connecting the posterior intestine to the rectal valve." [WB:WBbt\:0005773, WB:WBPaper00001423, WB:WBPerson2021] is_a: WBPhenotype:0000910 ! rectal_morphology_abnormal [Term] id: WBPhenotype:0001099 name: nose_twisted is_a: WBPhenotype:0000321 ! nose_morphology_abnormal [Term] id: WBPhenotype:0001100 name: early_embryonic_lethal synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0001101 name: egg_laying_response_to_drug_abnormal def: "Characteristic response to drugs with respect to egg-laying behavior is altered." [WB:cab] is_a: WBPhenotype:0000631 ! drug_response_abnormal is_a: WBPhenotype:0000640 ! egg_laying_abnormal [Term] id: WBPhenotype:0001102 name: mitotic_spindle_abnormal_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000759 ! spindle_abnormal_early_emb [Term] id: WBPhenotype:0001103 name: spindle_absent_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001102 ! mitotic_spindle_abnormal_early_emb [Term] id: WBPhenotype:0001104 name: P0_spindle_absent_early_emb def: "No mitotic spindle is seen in P0." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001103 ! spindle_absent_early_emb [Term] id: WBPhenotype:0001105 name: P0_spindle_position_abnormal_early_emb def: "Altered P0 spindle placement causes either a symmetric first division, a division in which P1 is larger than AB, or a division in which the asymmetry is exaggerated such that AB is much larger than normal." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000762 ! spindle_position_abnormal_early_emb [Term] id: WBPhenotype:0001106 name: spindle_orientation_abnormal_AB_or_P1_early_emb def: "The orientation of the spindle is aberrant in either the AB or the P1 cell." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000760 ! spindle_orientation_abnormal_early_emb [Term] id: WBPhenotype:0001107 name: spindle_rotation_abnormal_early_emb def: "Rotation of the embryonic spindle is aberrant." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001102 ! mitotic_spindle_abnormal_early_emb [Term] id: WBPhenotype:0001108 name: P0_spindle_rotation_failure_early_emb def: "P0 spindle fails to rotate and extends perpendicular to the long axis of the embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001107 ! spindle_rotation_abnormal_early_emb [Term] id: WBPhenotype:0001109 name: P0_spindle_rotation_delayed_early_emb def: "P0 spindle rotates late in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001107 ! spindle_rotation_abnormal_early_emb [Term] id: WBPhenotype:0001110 name: aster_abnormal_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001111 name: aster_AB_abnormal_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001110 ! aster_abnormal_early_emb [Term] id: WBPhenotype:0001112 name: aster_AB_resembles_P1_aster_early_emb def: "The morphology of the AB aster resembles that of the P1 aster in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001111 ! aster_AB_abnormal_early_emb [Term] id: WBPhenotype:0001113 name: P1_aster_abnormal_early_emb def: "The morphology of the P1 aster is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001110 ! aster_abnormal_early_emb [Term] id: WBPhenotype:0001114 name: cell_cycle_abnormal_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000740 ! cell_cycle_abnormal is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001115 name: cell_cycle_timing_abnormal_early_emb def: "Cell cycle timing is abnormal during the first four cell divisions." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001114 ! cell_cycle_abnormal_early_emb [Term] id: WBPhenotype:0001116 name: absolute_cell_cycle_timing_abnormal_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001115 ! cell_cycle_timing_abnormal_early_emb [Term] id: WBPhenotype:0001117 name: cell_cell_contacts_abnormal_early_emb def: "Cell-cell contacts are abnormal in the early embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001118 name: cell_position_abnormal_early_emb def: "Cell position is abnormal in the early embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001119 name: cell_cycle_slow_early_emb def: "Embryos take longer to divide during the first and second cell divisions." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001116 ! absolute_cell_cycle_timing_abnormal_early_emb [Term] id: WBPhenotype:0001120 name: relative_cell_cycle_timing_abnormal_early_emb def: "Relative cell cycle timing during the first two cell divisions is aberrant." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001115 ! cell_cycle_timing_abnormal_early_emb [Term] id: WBPhenotype:0001121 name: exaggerated_asynchrony_early_emb def: "Asynchrony of the second division is exaggerated and P1 divides more slowly than normal." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_abnormal_early_emb [Term] id: WBPhenotype:0001122 name: reversed_asynchrony_early_emb def: "P1 divides before AB." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_abnormal_early_emb [Term] id: WBPhenotype:0001123 name: synchronous_second_division_early_emb def: "AB and P1 divide synchronously." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_abnormal_early_emb [Term] id: WBPhenotype:0001124 name: ABa_ABp_EMS_synchronous_division_early_emb def: "EMS divides at the same time that ABa and ABp divide." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_abnormal_early_emb [Term] id: WBPhenotype:0001125 name: P2_EMS_synchronous_division_early_emb def: "P2 and EMS divide synchronously." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_abnormal_early_emb [Term] id: WBPhenotype:0001126 name: cell_cell_contacts_abnormal_four_emb def: "Aba, ABp, EMS, or P1 contacts fewer of its sister cells than in wild-type embryos." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001117 ! cell_cell_contacts_abnormal_early_emb [Term] id: WBPhenotype:0001127 name: EMS_anterior_extension_fails_early_emb def: "EMS fails to extend anteriorly and \"hug\" ABa." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001118 ! cell_position_abnormal_early_emb [Term] id: WBPhenotype:0001128 name: EMS_anterior_extension_extreme_early_emb def: "EMS extends too far anteriorly at the four cell stage." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001118 ! cell_position_abnormal_early_emb [Term] id: WBPhenotype:0001129 name: cleavage_furrow_abnormal_early_emb synonym: "cleavage_furrow_abnormal" RELATED [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001130 name: cytokinesis_fails_early_emb def: "Cells of the embryo attempt to divide but fail to form two daughter cells." [WB:cab, WB:cgc5599] synonym: "Cyk" BROAD three_letter_name [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001078 ! cytokinesis_abnormal_early_emb [Term] id: WBPhenotype:0001131 name: loose_mitotic_furrow_early_emb def: "Once formed, the mitotic furrow can \"slide\"laterally." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001129 ! cleavage_furrow_abnormal_early_emb [Term] id: WBPhenotype:0001132 name: ectopic_cleavage_furrows_early_emb def: "Extra cleavage furrows are seen in one or all cells of a one-cell to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001129 ! cleavage_furrow_abnormal_early_emb [Term] id: WBPhenotype:0001133 name: division_axis_abnormal_early_emb def: "Division axis within the first four divisions is not normal." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001134 name: Aba_ABp_division_axis_abnormal_early_emb def: "ABa or ABp divide in the wrong orientation." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001133 ! division_axis_abnormal_early_emb [Term] id: WBPhenotype:0001135 name: embryonic_morphology_abnormal_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal is_a: WBPhenotype:0001136 ! embryonic_morphology_abnormal [Term] id: WBPhenotype:0001136 name: embryonic_morphology_abnormal is_a: WBPhenotype:0000037 ! egg_morphology_abnormal [Term] id: WBPhenotype:0001137 name: embryos_small_early_emb def: "Embryos are produced that are less than fifty percent of the size of wild-type embryos." [WB:cab, WB:WBPaper00005599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001135 ! embryonic_morphology_abnormal_early_emb [Term] id: WBPhenotype:0001138 name: nucleus_abnormal_early_emb def: "Nucleus is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001034 ! pronuclear_nuclear_appearance_abnormal_early_emb [Term] id: WBPhenotype:0001139 name: nuclear_reassembly_abnormal_early_emb def: "Nuclear envelope does not reassemble properly." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001138 ! nucleus_abnormal_early_emb [Term] id: WBPhenotype:0001140 name: neuron_migration_abnormal def: "Any variation in the normal orderly movement of neurons from one site to another." [WB:WBPerson2021] is_a: WBPhenotype:0000594 ! cell_migration_abnormal [Term] id: WBPhenotype:0001141 name: nucleus_reforms_cell_division_remnant_early_emb def: "After division of either one-cell or two-cell embryos, the nuclei reappear next to the cell division remnant." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001027 ! nuclear_position_abnormal_early_emb [Term] id: WBPhenotype:0001142 name: nuclear_number_abnormal_early_emb def: "Nuclear number is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001035 ! nuclear_appearance_number_abnormal_early_emb [Term] id: WBPhenotype:0001143 name: multiple_nuclei_early_emb def: "Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "karyomeres" RELATED [] synonym: "Mul" BROAD three_letter_name [] synonym: "multiple_nuclei_in_early_embryo_emb" RELATED [] is_a: WBPhenotype:0000746 ! cell_division_abnormal is_a: WBPhenotype:0001142 ! nuclear_number_abnormal_early_emb [Term] id: WBPhenotype:0001144 name: polar_body_number_size_early_emb def: "Defects are either seen in the number or size of the polar bodies in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001147 ! polar_body_abnormal_early_emb [Term] id: WBPhenotype:0001145 name: polar_body_number_abnormal_early_emb def: "Polar body number is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001144 ! polar_body_number_size_early_emb [Term] id: WBPhenotype:0001146 name: polar_body_size_abnormal_early_emb def: "Polar body size is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001144 ! polar_body_number_size_early_emb [Term] id: WBPhenotype:0001147 name: polar_body_abnormal_early_emb def: "Polar bodies are abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001148 name: polar_body_reabsorbed_early_emb def: "Polar body is reabsorbed in the one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000777 ! polar_body_extrusion_abnormal_early_emb [Term] id: WBPhenotype:0001149 name: polar_body_reabsorbed_first_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001148 ! polar_body_reabsorbed_early_emb [Term] id: WBPhenotype:0001150 name: polar_body_reabsorbed_one_two_early_emb def: "A polar body is reabsorbed in either the one cell- or the two-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001148 ! polar_body_reabsorbed_early_emb [Term] id: WBPhenotype:0001151 name: pronucleus_centrosomes_abnormal_early_emb def: "Pronucleus is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001034 ! pronuclear_nuclear_appearance_abnormal_early_emb [Term] id: WBPhenotype:0001152 name: pronuclear_migration_abnormal_early_emb def: "Pronucleus migration is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_abnormal_early_emb [Term] id: WBPhenotype:0001153 name: pronuclear_migration_failure_early_emb def: "Neither of the pronuclei migrate and they never meet." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001152 ! pronuclear_migration_abnormal_early_emb [Term] id: WBPhenotype:0001154 name: paternal_pronucleus_migrates_early_emb def: "Instead of the maternal pronucleus migrating to the posterior end of the one-cell embryo, the paternal pronucleus migrates to meet the maternal pronucleus in the anterior end." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001152 ! pronuclear_migration_abnormal_early_emb [Term] id: WBPhenotype:0001155 name: pronuclei_meet_centrally_early_emb def: "The maternal and paternal pronuclei meet more centrally instead of meeting in the posterior end of the embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001152 ! pronuclear_migration_abnormal_early_emb [Term] id: WBPhenotype:0001156 name: pronuclear_size_abnormal_early_emb def: "Maternal or paternal pronucleus is either too small or too large." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001159 ! pronuclear_morphology_abnormal_early_emb [Term] id: WBPhenotype:0001157 name: pronuclear_breakdown_abnormal_early_emb def: "Pronuclear breakdown is atypical in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_abnormal_early_emb [Term] id: WBPhenotype:0001158 name: pronuclear_breakdown_asynchronous_early_emb def: "Instead of breaking down synchronously, the two pronuclei break down asynchronously in the inviable one-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001157 ! pronuclear_breakdown_abnormal_early_emb [Term] id: WBPhenotype:0001159 name: pronuclear_morphology_abnormal_early_emb def: "Pronucleus morphology is atypical in the inviable embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_abnormal_early_emb [Term] id: WBPhenotype:0001160 name: pronuclear_envelope_morphology_abnormal_early_emb def: "Morphology of the pronuclear envelope is atypical in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001159 ! pronuclear_morphology_abnormal_early_emb [Term] id: WBPhenotype:0001161 name: maternal_pronucleus_indistinct_early_emb def: "Maternal pronucleus has a blurry appearance. The nuclear envelope does not have a crisp circular shape." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001160 ! pronuclear_envelope_morphology_abnormal_early_emb [Term] id: WBPhenotype:0001162 name: pronuclear_number_abnormal_early_emb def: "There are more than two pronuclei in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_abnormal_early_emb [Term] id: WBPhenotype:0001163 name: pronucleus_formation_failure_early_emb def: "Either the maternal or paternal pronucleus is absent." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001162 ! pronuclear_number_abnormal_early_emb [Term] id: WBPhenotype:0001164 name: excess_pronucleus_early_emb def: "There is either more than one maternal or paternal pronucleus in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001162 ! pronuclear_number_abnormal_early_emb [Term] id: WBPhenotype:0001165 name: excess_maternal_pronucleus_early_emb def: "One-cell embryos have two or more maternal pronuclei." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001164 ! excess_pronucleus_early_emb [Term] id: WBPhenotype:0001166 name: excess_paternal_pronucleus_abnormal_centrosome_early_emb def: "More than one paternal pronucleus is present in the inviable one-cell embryo or there is a defect in centrosome structure." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001164 ! excess_pronucleus_early_emb [Term] id: WBPhenotype:0001167 name: pseudocleavage_abnormal_early_emb def: "Pseudocleavage is atypical in the inviable one-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001168 name: pseudocleavage_absent_early_emb def: "No pseudocleavage is observed before or during pronuclear migration." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] synonym: "no_pseudocleavage" RELATED [] is_a: WBPhenotype:0001167 ! pseudocleavage_abnormal_early_emb [Term] id: WBPhenotype:0001169 name: pseudocleavage_exaggerated_early_emb def: "Embryos have more pronounced pseudocleavage than normal." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001167 ! pseudocleavage_abnormal_early_emb [Term] id: WBPhenotype:0001170 name: sterile_F0_48_hours_post_injection def: "Injected worm stops producing embryos 48 hours after RNAi injection and contains no live/developing embryos at this time." [WB:cab, WB:cgc5599] synonym: "P0_sterile" NARROW [] synonym: "Ste" BROAD [] is_a: WBPhenotype:0000689 ! maternal_sterile [Term] id: WBPhenotype:0001171 name: shortened_life_span synonym: "Age" BROAD three_letter_name [] synonym: "longevity_decreased" RELATED [] is_a: WBPhenotype:0000039 ! life_span_abnormal [Term] id: WBPhenotype:0001172 name: programmed_cell_death_abnormal is_a: WBPhenotype:0000729 ! cell_death_abnormal [Term] id: WBPhenotype:0001173 name: non_apoptotic_cell_death_abnormal is_a: WBPhenotype:0001172 ! programmed_cell_death_abnormal [Term] id: WBPhenotype:0001174 name: chromosome_disjunction_abnormal is_a: WBPhenotype:0000773 ! chromosome_segregation_abnormal is_a: WBPhenotype:0000775 ! meiosis_abnormal [Term] id: WBPhenotype:0001175 name: high_incidence_male_progeny def: "Higher numbers of male progeny occur in the population as a result of an increase in X chromosome nondisjunction" [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPerson712] synonym: "high_frequency_X_chromosome_nondisjunction" RELATED [] synonym: "Him" BROAD three_letter_name [] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001176 name: one_cell_shape_abnormal_early_emb def: "One-cell embryos have an altered shape." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001135 ! embryonic_morphology_abnormal_early_emb [Term] id: WBPhenotype:0001177 name: embryo_osmotic_pressure_sensitive_early_emb def: "Embryos rupture when placed on a 2% agar pad and covered with a coverslip." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001178 ! egg_integrity_abnormal_early_emb [Term] id: WBPhenotype:0001178 name: egg_integrity_abnormal_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001179 name: No_abnormality_scored def: "Phenotypic examination of worms did not reveal an obvious abnormality compared with wild type." [WB:cab] comment: The phenotype ontology was restructured such that "Abnormal" is now the root term. The term "Abnormal" with a "Not" qualifier is a suggested replacement for this term. synonym: "WT" RELATED [] is_obsolete: true [Term] id: WBPhenotype:0001180 name: accumulated_germline_cell_corpses is_a: WBPhenotype:0000241 ! accumulated_cell_corpses [Term] id: WBPhenotype:0001181 name: accumulated_somatic_cell_corpses is_a: WBPhenotype:0000241 ! accumulated_cell_corpses [Term] id: WBPhenotype:0001182 name: fat_content_abnormal is_a: WBPhenotype:0000725 ! lipid_metabolism_abnormal [Term] id: WBPhenotype:0001183 name: fat_content_reduced is_a: WBPhenotype:0001182 ! fat_content_abnormal [Term] id: WBPhenotype:0001184 name: fat_content_increased is_a: WBPhenotype:0001182 ! fat_content_abnormal [Term] id: WBPhenotype:0001185 name: embryonic_developmental_delay_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001186 name: embryo_delayed_at_pronuclear_contact_early_emb def: "Embryos are either delayed or arrested at pronuclear contact." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001185 ! embryonic_developmental_delay_early_emb [Term] id: WBPhenotype:0001187 name: division_EMS_before_P1_early_emb synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_abnormal_early_emb [Term] id: WBPhenotype:0001188 name: radial_filament_structure_abnormal_pharynx relationship: part_of WBPhenotype:0001046 ! pharyngeal_muscle_morphology_abnormal [Term] id: WBPhenotype:0001189 name: adherens_junctions_abnormal_pharyngeal_muscle relationship: part_of WBPhenotype:0001046 ! pharyngeal_muscle_morphology_abnormal [Term] id: WBPhenotype:0001190 name: pharyngeal_physiology_abnormal relationship: part_of WBPhenotype:0000606 ! alimentary_system_physiology_abnormal [Term] id: WBPhenotype:0001191 name: pharyngeal_muscle_physiology_abnormal is_a: WBPhenotype:0001190 ! pharyngeal_physiology_abnormal [Term] id: WBPhenotype:0001192 name: calcium_signaling_pharynx_abnormal is_a: WBPhenotype:0001191 ! pharyngeal_muscle_physiology_abnormal [Term] id: WBPhenotype:0001193 name: disorganized_pharyngeal_EPG def: "Electropharyngeograms of mutants do not show a repeating, regular pattern. In wild type each pump is associated with an excitatory depolarizing wave, often punctuated by brief negative spikes, followed by a plateau phase, and ending with an inhibitory hyperpolarizing wave." [WB:cab, WB:cgc7545] is_a: WBPhenotype:0000980 ! pharyngeal_contraction_abnormal [Term] id: WBPhenotype:0001194 name: ectopic_neuron is_a: WBPhenotype:0001303 ! ectopic_cell [Term] id: WBPhenotype:0001195 name: generation_calcium_signal_defective_pharynx def: "Rhythmic calcium increases are observed less often than in wild type. In wild type rhythmic increases in intracellular calcium are observed using a transgenically expressed cameleon, a ratiometric calcium indicator." [WB:cab, WB:cgc4194, WB:cgc7545] is_a: WBPhenotype:0001192 ! calcium_signaling_pharynx_abnormal [Term] id: WBPhenotype:0001196 name: synchronization_calcium_signal_defective_pharynx def: "Calcium spikes are not synchronous in the musculature of the corpus and the terminal bulb." [WB:cab, WB:cgc7545] is_a: WBPhenotype:0001192 ! calcium_signaling_pharynx_abnormal [Term] id: WBPhenotype:0001197 name: somatic_gonad_physiology_abnormal relationship: part_of WBPhenotype:0000613 ! reproductive_system_physiology_abnormal [Term] id: WBPhenotype:0001198 name: somatic_sheath_physiology_abnormal is_a: WBPhenotype:0001197 ! somatic_gonad_physiology_abnormal [Term] id: WBPhenotype:0001199 name: gonad_sheath_contractions_abnormal is_a: WBPhenotype:0001198 ! somatic_sheath_physiology_abnormal [Term] id: WBPhenotype:0001200 name: gonad_sheath_contraction_rate_reduced def: "Basal contraction rate of the gonadal sheath is reduced relative to wild type." [WB:cab, WB:cgc7545] is_a: WBPhenotype:0001199 ! gonad_sheath_contractions_abnormal [Term] id: WBPhenotype:0001201 name: no_expulsion_defecation is_a: WBPhenotype:0000391 ! defecation_missing_motor_steps [Term] id: WBPhenotype:0001202 name: nicotine_hypersensitive def: "Worms display hypersensitivity to the effects of nicotine compared with wild type." [WB:cab, WB:cgc7388] is_a: WBPhenotype:0001573 ! nicotine_response_abnormal is_a: WBPhenotype:0001579 ! cholinergic_agonist_hypersensitive [Term] id: WBPhenotype:0001203 name: nicotine_resistant def: "Worms exhibit resistance to the effects of nicotine compared to wild type." [WB:cab, WB:cgc7388] is_a: WBPhenotype:0001573 ! nicotine_response_abnormal is_a: WBPhenotype:0001578 ! cholinergic_agonist_resistant [Term] id: WBPhenotype:0001204 name: muscimol_resistant is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001205 name: muscimol_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0001206 name: movement_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0001207 name: protein_signaling_abnormal is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0001208 name: RNAi_resistant is_a: WBPhenotype:0000743 ! RNAi_response_abnormal [Term] id: WBPhenotype:0001209 name: skiddy def: "Apparently normal sinusoidal movement, but appear to have poor traction on the agar surface of a culture plate." [WB:cab, WB:WBPaper00026735] synonym: "Skd" BROAD three_letter_name [] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0001210 name: pericellular_component_physiology_abnormal subset: phenotype_slim_wb is_a: WBPhenotype:0000519 ! physiology_abnormal [Term] id: WBPhenotype:0001211 name: cuticle_integrity_abnormal is_a: WBPhenotype:0001678 ! cuticle_physiology_abnormal [Term] id: WBPhenotype:0001212 name: cuticle_fragile is_a: WBPhenotype:0001211 ! cuticle_integrity_abnormal [Term] id: WBPhenotype:0001213 name: locomotion_reduced alt_id: WBPhenotype:0001288 def: "Animals remain at rest more often compared with wild-type animals." [WB:cab] synonym: "movement_reduced" EXACT [] is_a: WBPhenotype:0000641 ! activity_level_abnormal [Term] id: WBPhenotype:0001214 name: metaphase_to_anaphase_transition_fails is_obsolete: true [Term] id: WBPhenotype:0001215 name: germ_cell_mitosis_abnormal def: "Any alteration in the mitotic expansion of germ cell populations during development." [WB:WBPaper00001007, WB:WBPerson2021] is_a: WBPhenotype:0000823 ! germline_proliferation_abnormal [Term] id: WBPhenotype:0001216 name: meiosis_metaphase_to_anaphase_transition_block def: "Oocyte chromosomes arrest in metaphase of meiosis I without transitioning to anaphase or producing polar bodies." [pmid:11134076, WB:cab] synonym: "Mat" BROAD three_letter_name [] is_a: WBPhenotype:0000776 ! passage_through_meiosis_abnormal_early_emb is_a: WBPhenotype:0001496 ! metaphase_to_anaphase_transition_defect [Term] id: WBPhenotype:0001217 name: germ_cell_mitosis_metaphase_to_anaphase_transition_block is_a: WBPhenotype:0001215 ! germ_cell_mitosis_abnormal is_a: WBPhenotype:0001497 ! mitotic_metaphase_to_anaphase_transition_defect [Term] id: WBPhenotype:0001218 name: cell_death_sexually_dimorphic_abnormal is_a: WBPhenotype:0000730 ! apoptosis_abnormal [Term] id: WBPhenotype:0001219 name: cell_survival_sexually_dimorphic_increased_ is_a: WBPhenotype:0001218 ! cell_death_sexually_dimorphic_abnormal [Term] id: WBPhenotype:0001220 name: cell_death_sexually_dimorphic_increased is_a: WBPhenotype:0001218 ! cell_death_sexually_dimorphic_abnormal [Term] id: WBPhenotype:0001221 name: nose_touch_defective def: "Animal does not respond with characteristic backward movement after a nose-on collision with an object, usually assayed with a hair or similar fiber. The nose is the anterior most tip of the animal. " [WB:WBPaper00001705, WB:WBPerson557] is_a: WBPhenotype:0000456 ! touch_resistant is_a: WBPhenotype:0004026 ! nose_touch_abnormal [Term] id: WBPhenotype:0001222 name: transposon_mutator synonym: "Mut" RELATED [] synonym: "mutator" RELATED [] is_a: WBPhenotype:0000228 ! spontaneous_mutation_rate_increased [Term] id: WBPhenotype:0001223 name: germline_RNAi_resistant is_a: WBPhenotype:0001208 ! RNAi_resistant [Term] id: WBPhenotype:0001224 name: axon_outgrowth_abnormal def: "Any aberrancy in the processes that govern the extension of axons." [GO:0048675, WB:WBPerson2021] is_a: WBPhenotype:0000572 ! neuronal_outgrowth_abnormal [Term] id: WBPhenotype:0001225 name: phasmid_socket_absent def: "Animals are missing the interfacial hypodermal cell (socket cell) of the phasmid sensillum pore." [WB:WBPaper00000938, WB:WBPaper00026656, WB:WBPerson712] synonym: "Psa" RELATED [] is_a: WBPhenotype:0000257 ! phasmid_morphology_abnormal [Term] id: WBPhenotype:0001226 name: commissure_abnormal def: "Animals display deviations in the structure, organization or path of the part of the axon that forms a bridge between body regions, compared to that in normal animals." [WB:WBPaper00000938, WB:WBPaper00001576, WB:WBPaper00029065, WB:WBPerson712] is_a: WBPhenotype:0000181 ! axon_trajectory_abnormal [Term] id: WBPhenotype:0001227 name: commissure_absent def: "Animals are missing any one of its commissures, an axon tract that connects one body part to another." [WB:WBPaper00027335, WB:WBPerson712] is_a: WBPhenotype:0001226 ! commissure_abnormal [Term] id: WBPhenotype:0001228 name: alae_absent is_a: WBPhenotype:0000202 ! alae_abnormal [Term] id: WBPhenotype:0001229 name: abnormal_anterior_neuron_migration def: "The orderly movement of neurons along the anterior axis of the animal is perturbed (abolished, misdirected or incomplete)." [WB:WBPerson2021] is_a: WBPhenotype:0001140 ! neuron_migration_abnormal [Term] id: WBPhenotype:0001230 name: abnormal_anterior_cell_migration def: "The orderly movement of cells along the anterior axis of the animal is perturbed (abolished, misdirected or incomplete)." [WB:WBPerson2021] is_a: WBPhenotype:0000594 ! cell_migration_abnormal [Term] id: WBPhenotype:0001231 name: intraflagellar_transport_accelerated synonym: "ift_accelerated" RELATED [] is_a: WBPhenotype:0000853 ! intraflagellar_transport_abnormal [Term] id: WBPhenotype:0001232 name: serotonin_response_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0001233 name: DAPI_staining_abnormal is_a: WBPhenotype:0010002 ! cell_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001234 name: nonanone_chemotaxis_defective def: "Failure to execute the characteristic avoidance response to nonanone." [WB:WBPaper00002917] is_a: WBPhenotype:0001448 ! odorant_negative_chemotaxis_defective is_a: WBPhenotype:0001456 ! nonanone_chemotaxis_abnormal [Term] id: WBPhenotype:0001235 name: cell_division_polarity_abnormal is_a: WBPhenotype:0000746 ! cell_division_abnormal [Term] id: WBPhenotype:0001236 name: transgene_expression_increased def: "Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in normal animals." [WB:WBPerson557] is_a: WBPhenotype:0000962 ! level_of_transgene_expression_abnormal [Term] id: WBPhenotype:0001237 name: ectopic_axon_outgrowth def: "Any perturbation that causes an increase in the frequency of axon outgrowth. As a result, an excess number of axonal projections are generated." [GO:0030517, WB:WBPerson2021] is_a: WBPhenotype:0000629 ! ectopic_neurite_outgrowth is_a: WBPhenotype:0001224 ! axon_outgrowth_abnormal [Term] id: WBPhenotype:0001238 name: male_mating_latency_abnormal def: "Any abnormality in the length of time required for a male to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva." [pmid:16624900, WB:cab] is_a: WBPhenotype:0000648 ! male_mating_abnormal [Term] id: WBPhenotype:0001239 name: mating_latency_increased is_a: WBPhenotype:0001238 ! male_mating_latency_abnormal is_a: WBPhenotype:0001414 ! male_mating_defective [Term] id: WBPhenotype:0001240 name: male_tail_sensory_ray_differentiation_abnormal is_a: WBPhenotype:0000199 ! male_tail_sensory_ray_development_abnormal [Term] id: WBPhenotype:0001241 name: ray_fusion is_a: WBPhenotype:0000165 ! cell_fusion_abnormal is_a: WBPhenotype:0000199 ! male_tail_sensory_ray_development_abnormal [Term] id: WBPhenotype:0001242 name: intraflagellar_transport_slow is_a: WBPhenotype:0000854 ! intraflagellar_transport_defective [Term] id: WBPhenotype:0001243 name: intraflagellar_transport_distance_short is_a: WBPhenotype:0001247 ! anterograde_transport_defective [Term] id: WBPhenotype:0001244 name: intraflagellar_transport_absent is_a: WBPhenotype:0000854 ! intraflagellar_transport_defective [Term] id: WBPhenotype:0001245 name: no_transport_middle_segment_cilia is_a: WBPhenotype:0001243 ! intraflagellar_transport_distance_short [Term] id: WBPhenotype:0001246 name: no_transport_distal_segment_cilia is_a: WBPhenotype:0001243 ! intraflagellar_transport_distance_short [Term] id: WBPhenotype:0001247 name: anterograde_transport_defective is_a: WBPhenotype:0001477 ! anterograde_transport_abnormal [Term] id: WBPhenotype:0001248 name: wing_cilia_morphology_abnormal def: "Animals exhibit deviations in the structure or organization of the microtuble-based projections that normally invaginate individually into the sheath cell of the neuronal sensillum rather than projecting through the socket cell to the outside. In normal animals the cilia of each wing cell has its own unique shape and as they are not exposed to the outside, they do not typically take up dyes." [WB:WBPaper00000932, WB:WBPaper00029016, WB:WBPerson712] synonym: "AWC_cilia_morphology_abnormal" RELATED [] is_a: WBPhenotype:0000615 ! cilia_morphology_abnormal [Term] id: WBPhenotype:0001249 name: amphid_channel_cilia_morphology_abnormal def: "Animals exhibit abnormalities in the structure or composition of the dendritic projections of the amphid sensory neurons that traverse the sensillum pore to connect with the outside of the animal, compared to that observed in normal animals. Amphid channel cilia morphology is frequently assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000615 ! cilia_morphology_abnormal [Term] id: WBPhenotype:0001250 name: amphid_channel_axoneme_morphology_abnormal def: "Animals exhibit abnormalities in the structure or composition of the microtuble-based fibrillar core, axoneme, of the cilia of the neurons that project through the sensillum pore to the outside of the animal, compared to that observed in normal animals." [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000262 ! axoneme_morphology_abnormal is_a: WBPhenotype:0001249 ! amphid_channel_cilia_morphology_abnormal [Term] id: WBPhenotype:0001251 name: amphid_channel_axoneme_short def: "The microtuble-based fibrillar-bundles of the amphid sensory cilia are reduced in length compared to those in normal animals. " [WB:WBPaper00000932, WB:WBPaper00027116, WB:WBPerson712] is_a: WBPhenotype:0001250 ! amphid_channel_axoneme_morphology_abnormal [Term] id: WBPhenotype:0001252 name: wing_cilia_axoneme_morphology_abnormal def: "Animals exhibit deviations in the structure or organization of the microtubule-based fibrillar section, axoneme, of the cilia of the flat sheet-like cells associated with sensory function, from that observed in normal animals." [WB:WBPerson712] is_a: WBPhenotype:0001248 ! wing_cilia_morphology_abnormal [Term] id: WBPhenotype:0001253 name: wing_cilia_axoneme_short def: "The microtuble-based fibrillar-bundle, axoneme, of the wing cell cilia are reduced in length and do not extend into the sheath cell as far as they do in normal animals." [WB:WBPerson712] is_a: WBPhenotype:0001252 ! wing_cilia_axoneme_morphology_abnormal [Term] id: WBPhenotype:0001254 name: amphid_channel_cilia_bulbous def: "The dendritic processes that normally extend through the amphid sensillum pore to the outside are truncated and have swollen ends as opposed to the extended and finger-like tips of channel cilia in normal animals. " [WB:WBPaper00027116, WB:WBPerson712] is_a: WBPhenotype:0001249 ! amphid_channel_cilia_morphology_abnormal [Term] id: WBPhenotype:0001255 name: wing_cilia_bulbous def: "Animals exhibit wing cell sensory cilia that are truncated and swollen unlike that observed in normal animals." [WB:WBPaper00027116, WB:WBPerson712] is_a: WBPhenotype:0001248 ! wing_cilia_morphology_abnormal [Term] id: WBPhenotype:0001256 name: DNA_damage_induced_focus_formation_abnormal synonym: "DNA_repair_induced_focus_formation" RELATED [] is_a: WBPhenotype:0000739 ! DNA_damage_response_abnormal [Term] id: WBPhenotype:0001257 name: cross_link_induced_focus_formation_abnormal is_a: WBPhenotype:0001256 ! DNA_damage_induced_focus_formation_abnormal [Term] id: WBPhenotype:0001258 name: RNAi_enhanced is_a: WBPhenotype:0000743 ! RNAi_response_abnormal [Term] id: WBPhenotype:0001259 name: hermaphrodite_fertility_reduced is_a: WBPhenotype:0000806 ! hermaphrodite_fertility_abnormal [Term] id: WBPhenotype:0001260 name: oocyte_morphology_abnormal is_a: WBPhenotype:0000900 ! germ_cell_morphology_abnormal [Term] id: WBPhenotype:0001261 name: pale is_a: WBPhenotype:0000527 ! organism_pigmentation_abnormal [Term] id: WBPhenotype:0001262 name: vulval_development_incomplete is_a: WBPhenotype:0000699 ! vulva_development_abnormal [Term] id: WBPhenotype:0001263 name: peroxisome_morphology_abnormal def: "The morphological appearance of peroxisomes is abnormal compared to wild type." [WB:cab] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0001264 name: peroxisome_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0001265 name: head_movement_abnormal def: "Erratic head vibration" [WB:WBPaper00000214] is_a: WBPhenotype:0001699 ! localized_movement_abnormal [Term] id: WBPhenotype:0001266 name: genetic_pathway_activation_abnormal is_a: WBPhenotype:0000074 ! genetic_pathway_abnormal [Term] id: WBPhenotype:0001267 name: induced_contraction_rate_abnormal is_a: WBPhenotype:0001199 ! gonad_sheath_contractions_abnormal [Term] id: WBPhenotype:0001268 name: induced_cell_death_abnormal is_a: WBPhenotype:0000729 ! cell_death_abnormal [Term] id: WBPhenotype:0001269 name: pathogen_induced_cell_death_abnormal is_a: WBPhenotype:0001268 ! induced_cell_death_abnormal [Term] id: WBPhenotype:0001270 name: pathogen_induced_cell_death_reduced is_a: WBPhenotype:0001269 ! pathogen_induced_cell_death_abnormal [Term] id: WBPhenotype:0001271 name: pathogen_induced_death_increased is_a: WBPhenotype:0001013 ! pathogen_susceptibility_increased [Term] id: WBPhenotype:0001272 name: vulval_cell_induction_abnormal alt_id: WBPhenotype:0000198 def: "Any alteration that causes certain vulval precursor cells to adopt fates that are normally restricted to other vulval precursor cells." [WB:WBPerson2021] synonym: "vulval_precursor_cell_induction_abnormal" EXACT [] is_a: WBPhenotype:0000220 ! vulva_cell_fate_specification_abnormal [Term] id: WBPhenotype:0001273 name: organism_heat_response_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0001274 name: organism_heat_hypersensitive is_a: WBPhenotype:0001273 ! organism_heat_response_abnormal [Term] id: WBPhenotype:0001275 name: increased_genetic_pathway_signal is_a: WBPhenotype:0000074 ! genetic_pathway_abnormal [Term] id: WBPhenotype:0001276 name: ectopic_expression_transgene def: "Any variation in the cellular expression of a gene product produced by exogenous DNA that has been introduced into the organism such that it now expresses in cells/tissues not seen when compared to the expression of that gene product in normal animals." [WB:WBPerson557] is_a: WBPhenotype:0000961 ! pattern_of_transgene_expression_abnormal [Term] id: WBPhenotype:0001277 name: transformer def: "XX animals are transformed into males or pseudomales ." [WB:cab, WB:WBPerson712] synonym: "Tra" RELATED [] is_a: WBPhenotype:0001572 ! masculinized [Term] id: WBPhenotype:0001278 name: transgene_expression_reduced def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in normal animals." [WB:WBPerson557] is_a: WBPhenotype:0000962 ! level_of_transgene_expression_abnormal [Term] id: WBPhenotype:0001279 name: transgene_expression_reduced_male def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the male, that has been introduced into the organism compared to its expression in normal animals." [WB:WBPerson557] is_a: WBPhenotype:0001278 ! transgene_expression_reduced [Term] id: WBPhenotype:0001280 name: transgene_expression_reduced_hermaphrodite def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the hermaphrodite, that has been introduced into the organism compared to its expression in normal animals." [WB:WBPerson557] is_a: WBPhenotype:0001278 ! transgene_expression_reduced [Term] id: WBPhenotype:0001281 name: stuffed_pharynx def: "Pharynx becomes stuffed with food as a result of pharyngeal pumping defects." [WB:cab] is_a: WBPhenotype:0000085 ! swollen_intestine is_a: WBPhenotype:0000634 ! pharyngeal_pumping_abnormal is_a: WBPhenotype:0000778 ! feeding_inefficient [Term] id: WBPhenotype:0001282 name: mitochondrial_metabolism_abnormal is_a: WBPhenotype:0001283 ! organelle_metabolism_abnormal [Term] id: WBPhenotype:0001283 name: organelle_metabolism_abnormal is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0001284 name: coenzyme_Q_depleted is_a: WBPhenotype:0000026 ! lipid_depleted is_a: WBPhenotype:0001282 ! mitochondrial_metabolism_abnormal [Term] id: WBPhenotype:0001285 name: induced_pharyngeal_pumping_abnormal is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_abnormal [Term] id: WBPhenotype:0001286 name: food_suppressed_pumping_abnormal is_a: WBPhenotype:0001072 ! response_to_food_abnormal is_a: WBPhenotype:0001287 ! suppressed_pharyngeal_pumping_abnormal [Term] id: WBPhenotype:0001287 name: suppressed_pharyngeal_pumping_abnormal is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_abnormal [Term] id: WBPhenotype:0001289 name: acetylcholinesterase_inhibitor_resistant is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0001290 ! acetylcholinesterase_inhibitor_response_abnormal [Term] id: WBPhenotype:0001290 name: acetylcholinesterase_inhibitor_response_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0001291 name: social_behavior_abnormal is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0001292 name: body_wall_muscle_physiology_abnormal relationship: part_of WBPhenotype:0000611 ! muscle_system_physiology_abnormal [Term] id: WBPhenotype:0001293 name: larval_physiology_abnormal is_a: WBPhenotype:0000576 ! organism_physiology_abnormal [Term] id: WBPhenotype:0001294 name: head_bent is_a: WBPhenotype:0000071 ! head_morphology_abnormal [Term] id: WBPhenotype:0001295 name: body_twisted is_a: WBPhenotype:0000072 ! body_morphology_abnormal [Term] id: WBPhenotype:0001296 name: lannate_resistant is_a: WBPhenotype:0001289 ! acetylcholinesterase_inhibitor_resistant [Term] id: WBPhenotype:0001297 name: male_tail_development_abnormal is_a: WBPhenotype:0000805 ! tail_development_abnormal [Term] id: WBPhenotype:0001298 name: hindgut_morphology_abnormal is_a: WBPhenotype:0000710 ! intestinal_morphology_abnormal [Term] id: WBPhenotype:0001299 name: cell_division_abnormal_male is_a: WBPhenotype:0000746 ! cell_division_abnormal [Term] id: WBPhenotype:0001300 name: germ_cell_cytoplasmic_morphology_abnormal is_a: WBPhenotype:0000900 ! germ_cell_morphology_abnormal [Term] id: WBPhenotype:0001301 name: P_granule_abnormal def: "P-granule localization or structural appearance abnormal. P-granules are cytoplasmic structures associated with germ nuclei in the C. elegans gonad, and are localized exclusively to germ cells, or germ cell precursors, throughout the life cycle." [pmid:11262230, WB:cab] is_a: WBPhenotype:0001300 ! germ_cell_cytoplasmic_morphology_abnormal [Term] id: WBPhenotype:0001302 name: P_granule_localization_abnormal def: "The restricted localization of P granules to germ cells or germ cell precursors is altered. " [WB:WBPaper00001477, WB:WBPerson2021] is_a: WBPhenotype:0001301 ! P_granule_abnormal [Term] id: WBPhenotype:0001303 name: ectopic_cell is_a: WBPhenotype:0000529 ! cell_development_abnormal [Term] id: WBPhenotype:0001304 name: hindgut_damaged def: "Damage to the hindgut that can include scarring or blockage." [WB:cab, WB:WBPaper00003719] synonym: "Scar" BROAD three_letter_name [] is_a: WBPhenotype:0001298 ! hindgut_morphology_abnormal [Term] id: WBPhenotype:0001305 name: hook_morphology_abnormal relationship: part_of WBPhenotype:0000070 ! male_tail_morphology_abnormal [Term] id: WBPhenotype:0001306 name: male_reproductive_system_morphology_abnormal is_a: WBPhenotype:0000605 ! reproductive_system_morphology_abnormal [Term] id: WBPhenotype:0001307 name: reduced_body_bend is_a: WBPhenotype:0001703 ! body_bend_abnormal [Term] id: WBPhenotype:0001308 name: weak_pumping is_a: WBPhenotype:0000634 ! pharyngeal_pumping_abnormal [Term] id: WBPhenotype:0001309 name: flat_locomotion_path alt_id: WBPhenotype:0000003 synonym: "flattened_locomotion_path" EXACT [] is_a: WBPhenotype:0004022 ! amplitude_of_movement_abnormal [Term] id: WBPhenotype:0001310 name: neuron_positioning_abnormal is_a: WBPhenotype:0000604 ! nervous_system_morphology_abnormal [Term] id: WBPhenotype:0001311 name: protein_expression_reduced_hermaphrodite is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0001312 name: neuron_number_abnormal def: "The quantity of neuronal cells, as a whole or of a specific class of neuron in the animal deviates from that observed in normal animals. " [WB:WBPaper00027711, WB:WBPerson712] is_a: WBPhenotype:0000604 ! nervous_system_morphology_abnormal [Term] id: WBPhenotype:0001313 name: uterine_muscle_abnormal is_a: WBPhenotype:0000282 ! hermaphrodite_sex_muscle_development_abnormal [Term] id: WBPhenotype:0001314 name: vulval_muscle_abnormal is_a: WBPhenotype:0000282 ! hermaphrodite_sex_muscle_development_abnormal [Term] id: WBPhenotype:0001315 name: electrophysiology_abnormal is_a: WBPhenotype:0000576 ! organism_physiology_abnormal [Term] id: WBPhenotype:0001316 name: evoked_postsynaptic_current_abnormal is_a: WBPhenotype:0001315 ! electrophysiology_abnormal [Term] id: WBPhenotype:0001317 name: evoked_postsynaptic_amplitude_reduced is_a: WBPhenotype:0001316 ! evoked_postsynaptic_current_abnormal [Term] id: WBPhenotype:0001318 name: endogenous_synaptic_events_abnormal is_a: WBPhenotype:0001315 ! electrophysiology_abnormal [Term] id: WBPhenotype:0001319 name: endogenous_synaptic_event_frequency_reduced is_a: WBPhenotype:0001318 ! endogenous_synaptic_events_abnormal [Term] id: WBPhenotype:0001320 name: endogenous_synaptic_amplitude_abnormal is_a: WBPhenotype:0001318 ! endogenous_synaptic_events_abnormal [Term] id: WBPhenotype:0001321 name: presynaptic_region_morphology_abnormal def: "Animals display deviations in the structure, configuration, distribution or ratio of the components of the vesicle-filled varicosities of the synapse." [GO:0042734, WB:WBPaper00000938, WB:WBPaper00027305, WB:WBPaper00028886, WB:WBPerson712] relationship: part_of WBPhenotype:0000616 ! synapse_morphology_abnormal [Term] id: WBPhenotype:0001322 name: vesicle_number_reduced def: "Total presynaptic vesicle number is reduced, possibly refecting a defect in the replenishment of synaptic vesicles." [pmid:16803962, WB:cab] comment: Electron microscopic analysis is_a: WBPhenotype:0001332 ! vesicle_number_abnormal [Term] id: WBPhenotype:0001323 name: vesicle_morphology_abnormal def: "Animals display alterations in the shape or size of their vesicles, which are spherical, membrane-bound fluid-filled organelles, compared to vesicles observed in normal animals." [GO:0031982, pmid:16803962, WB:cab, WB:WBPaper00027612, WB:WBPaper00027711, WB:WBPerson712] comment: Electron microscopic analysis relationship: part_of WBPhenotype:0001671 ! vesicle_organization_abnormal [Term] id: WBPhenotype:0001324 name: cell_ionizing_radiation_response_abnormal is_a: WBPhenotype:0000142 ! cell_stress_response_abnormal [Term] id: WBPhenotype:0001325 name: backing_not_sustained def: "Animals initiate but do not continue backward movement, unlike wild-type animals." [WB:cab, WB:cgc914] is_a: WBPhenotype:0001005 ! backward_locomotion_abnormal [Term] id: WBPhenotype:0001326 name: cell_gamma_ray_response_abnormal is_a: WBPhenotype:0001324 ! cell_ionizing_radiation_response_abnormal [Term] id: WBPhenotype:0001327 name: cell_gamma_ray_hypersensitive is_a: WBPhenotype:0001326 ! cell_gamma_ray_response_abnormal [Term] id: WBPhenotype:0001328 name: posterior_body_dumpy is_a: WBPhenotype:0000793 ! posterior_body_morphology_abnormal [Term] id: WBPhenotype:0001329 name: curly def: "Multiply curved posture (posture assumes more than a single sine wave)." [WB:cab, WB:cgc914] is_a: WBPhenotype:0000001 ! body_posture_abnormal [Term] id: WBPhenotype:0001330 name: egg_laying_event_infrequent synonym: "egg_laying_event_rare" RELATED [] is_a: WBPhenotype:0000006 ! egg_laying_defective is_a: WBPhenotype:0000272 ! egg_laying_irregular [Term] id: WBPhenotype:0001331 name: motor_neuron_morphology_abnormal def: "Animals display deviations in the structure or organization of components of the motor neuron, internal to the cell itself or in relation to the cellular environment. A motor neuron is a neuronal cell that synapses to an effector (muscle, gland etc.), compared to that observed in normal animals. " [WB:WBbt\:0005409, WB:WBPerson712] is_a: WBPhenotype:0000905 ! neuron_morphology_abnormal [Term] id: WBPhenotype:0001332 name: vesicle_number_abnormal is_a: WBPhenotype:0001671 ! vesicle_organization_abnormal [Term] id: WBPhenotype:0001333 name: neuron_cell_body_absent is_a: WBPhenotype:0000816 ! neuron_development_abnormal [Term] id: WBPhenotype:0001334 name: hermaphrodite_sex_muscle_morphology_abnormal relationship: part_of WBPhenotype:0001335 ! hermaphrodite_reproductive_system_morphology_abnormal [Term] id: WBPhenotype:0001335 name: hermaphrodite_reproductive_system_morphology_abnormal is_a: WBPhenotype:0000605 ! reproductive_system_morphology_abnormal [Term] id: WBPhenotype:0001336 name: male_mating_efficiency_eliminated def: "Males sire no cross progeny." [WB:WBPaper00000179, WB:WBPaper00000608, WB:WBPerson557] synonym: "no_male_progeny" EXACT [] is_a: WBPhenotype:0000843 ! male_mating_efficiency_reduced [Term] id: WBPhenotype:0001337 name: adrenergic_receptor_antagonist_response_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0001338 name: phentolamine_resistant is_a: WBPhenotype:0001337 ! adrenergic_receptor_antagonist_response_abnormal [Term] id: WBPhenotype:0001339 name: egg_laying_levamisole_resistant def: "Animals are not induced to lay eggs in reponse to exogenous levamisole. Levamisole stimulates egg-laying in normal animals." [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0000421 ! levamisole_resistant is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_abnormal [Term] id: WBPhenotype:0001340 name: egg_laying_imipramine_resistant def: "Animals are not induced to lay eggs in reponse to exogenous imipramine. Imipramine stimulates egg-laying in normal animals." [WB:WBPaper00000635, WB:WBPaper00001133, WB:WBPaper00031293, WB:WBPerson712] is_a: WBPhenotype:0000340 ! imipramine_resistant is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_abnormal [Term] id: WBPhenotype:0001341 name: egg_laying_phentolamine_resistant def: "Animals are not induced to lay eggs in reponse to exogenous phentolamine. Phentolamine stimulates egg-laying in normal animals." [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_abnormal is_a: WBPhenotype:0001338 ! phentolamine_resistant [Term] id: WBPhenotype:0001342 name: egg_laying_imipramine_hypersensitive def: "Animals respond more to exogenous imipramine at a lower concentration or within a shorter time period than normal animals under the same conditions." [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_abnormal [Term] id: WBPhenotype:0001343 name: meiotic_spindle_abnormal_early_emb is_a: WBPhenotype:0000759 ! spindle_abnormal_early_emb [Term] id: WBPhenotype:0001344 name: organelle_organization_biogenesis_abnormal is_a: WBPhenotype:0010002 ! cell_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001345 name: cytoskeleton_organization_biogenesis_abnormal is_a: WBPhenotype:0001344 ! organelle_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001346 name: actin_cytoskeleton_dynamic_abnormal is_a: WBPhenotype:0001587 ! actin_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001347 name: intestinal_calcium_signaling_abnormal is_a: WBPhenotype:0001093 ! intestinal_physiology_abnormal [Term] id: WBPhenotype:0001348 name: chromosome_morphology_abnormal relationship: part_of WBPhenotype:0001028 ! nuclear_appearance_abnormal [Term] id: WBPhenotype:0001349 name: protein_phosphorylation_abnormal is_a: WBPhenotype:0001382 ! protein_modification_abnormal [Term] id: WBPhenotype:0001350 name: protein_phosphorylation_increased is_a: WBPhenotype:0001349 ! protein_phosphorylation_abnormal [Term] id: WBPhenotype:0001351 name: protein_phosphorylation_reduced is_a: WBPhenotype:0001349 ! protein_phosphorylation_abnormal [Term] id: WBPhenotype:0001352 name: endoplasmic_reticulum_metabolism_abnormal synonym: "er_metabolism_abnormal" RELATED [] is_a: WBPhenotype:0001283 ! organelle_metabolism_abnormal [Term] id: WBPhenotype:0001353 name: centration_abnormal_early_emb is_a: WBPhenotype:0001152 ! pronuclear_migration_abnormal_early_emb [Term] id: WBPhenotype:0001354 name: actin_cytoskeleton_filament_morphology_abnormal is_a: WBPhenotype:0001587 ! actin_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001355 name: gonad_morphology_abnormal relationship: part_of WBPhenotype:0000605 ! reproductive_system_morphology_abnormal [Term] id: WBPhenotype:0001356 name: male_sex_muscle_morphology_abnormal is_a: WBPhenotype:0001024 ! male_morphology_abnormal [Term] id: WBPhenotype:0001357 name: male_gonad_morphology_abnormal is_a: WBPhenotype:0001024 ! male_morphology_abnormal [Term] id: WBPhenotype:0001358 name: male_nervous_system_morphology_abnormal is_a: WBPhenotype:0001024 ! male_morphology_abnormal [Term] id: WBPhenotype:0001359 name: proctodeum_morphology_abnormal def: "Animals exhibit deviations in the structure and organization of the chamber in the male tail that extends from the termination of four canals (vas deferens, gut, and left and right spicule channels) to just before the cloaca, from that observed in normal animals." [WB:WBPaper00027278, WB:WBPerson712] relationship: part_of WBPhenotype:0000070 ! male_tail_morphology_abnormal [Term] id: WBPhenotype:0001360 name: hermaphrodite_self_sterile is_a: WBPhenotype:0000694 ! hermaphrodite_sterile [Term] id: WBPhenotype:0001361 name: chromosome_condensation_abnormal is_a: WBPhenotype:0000775 ! meiosis_abnormal [Term] id: WBPhenotype:0001362 name: chromosome_condensation_failure is_a: WBPhenotype:0001361 ! chromosome_condensation_abnormal [Term] id: WBPhenotype:0001363 name: head_cavity def: "The head contains cavities, possibly indicative of inappropriate cell death." [WB:cab] synonym: "head_vacuole" RELATED [] is_a: WBPhenotype:0000071 ! head_morphology_abnormal [Term] id: WBPhenotype:0001364 name: male_fan_morphology_abnormal relationship: part_of WBPhenotype:0000070 ! male_tail_morphology_abnormal [Term] id: WBPhenotype:0001365 name: male_bursa_development_abnormal relationship: part_of WBPhenotype:0001297 ! male_tail_development_abnormal [Term] id: WBPhenotype:0001366 name: male_fan_development_abnormal relationship: part_of WBPhenotype:0001297 ! male_tail_development_abnormal [Term] id: WBPhenotype:0001367 name: proctodeum_development_abnormal relationship: part_of WBPhenotype:0001297 ! male_tail_development_abnormal [Term] id: WBPhenotype:0001368 name: spermatheca_absent is_a: WBPhenotype:0001662 ! spermatheca_development_abnormal [Term] id: WBPhenotype:0001369 name: protein_interaction_abnormal is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0001370 name: protein_protein_interaction_abnormal is_a: WBPhenotype:0001369 ! protein_interaction_abnormal [Term] id: WBPhenotype:0001371 name: protein_RNA_interaction_abnormal is_a: WBPhenotype:0001369 ! protein_interaction_abnormal [Term] id: WBPhenotype:0001372 name: protein_DNA_interaction_abnormal is_a: WBPhenotype:0001369 ! protein_interaction_abnormal [Term] id: WBPhenotype:0001373 name: protein_rna_interaction_abolished is_a: WBPhenotype:0001371 ! protein_RNA_interaction_abnormal [Term] id: WBPhenotype:0001374 name: pronuclear_nuclear_appearance_abnormal_emb def: "The shape and size of nuclei as well as the distribution of nucleoporins are strongly affected." [WB:cab, WB:WBPaper00028895] synonym: "Pna" RELATED [] is_a: WBPhenotype:0000764 ! embryonic_cell_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001375 name: transgene_expression_undetectable def: "The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection. " [WB:WBPerson557] is_a: WBPhenotype:0001278 ! transgene_expression_reduced [Term] id: WBPhenotype:0001376 name: transgene_expression_undetectable_cell_specific def: "The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection in specific cells." [WB:WBPerson557] is_a: WBPhenotype:0001375 ! transgene_expression_undetectable [Term] id: WBPhenotype:0001377 name: break_induced_focus_formation_abnormal is_a: WBPhenotype:0001256 ! DNA_damage_induced_focus_formation_abnormal is_a: WBPhenotype:0001324 ! cell_ionizing_radiation_response_abnormal [Term] id: WBPhenotype:0001378 name: mitotic_chromosome_segregation_abnormal is_a: WBPhenotype:0000773 ! chromosome_segregation_abnormal [Term] id: WBPhenotype:0001379 name: organism_toxic_chemical_response_abnormal is_a: WBPhenotype:0000523 ! chemical_response_abnormal [Term] id: WBPhenotype:0001380 name: anoxia_hypersensitive is_a: WBPhenotype:0000464 ! oxygen_response_abnormal [Term] id: WBPhenotype:0001381 name: anoxia_resistant is_a: WBPhenotype:0000464 ! oxygen_response_abnormal [Term] id: WBPhenotype:0001382 name: protein_modification_abnormal is_a: WBPhenotype:0000112 ! protein_expression_abnormal [Term] id: WBPhenotype:0001383 name: protein_methylation_abnormal is_a: WBPhenotype:0001382 ! protein_modification_abnormal [Term] id: WBPhenotype:0001384 name: fertility_reduced is_a: WBPhenotype:0000145 ! fertility_abnormal [Term] id: WBPhenotype:0001385 name: precocious_oogenesis def: "Relatively unspecialized germ cells prematurely acquire the specialized properties of mature oocytes." [WB:WBPaper00001475, WB:WBPaper00028819, WB:WBPerson2021] is_a: WBPhenotype:0000186 ! oogenesis_abnormal [Term] id: WBPhenotype:0001386 name: fertilization_defective_hermaphrodite is_a: WBPhenotype:0000983 ! fertilization_defective [Term] id: WBPhenotype:0001387 name: fertilization_defect_male is_a: WBPhenotype:0000983 ! fertilization_defective [Term] id: WBPhenotype:0001388 name: organism_hypersensitive_gamma_irradiation is_a: WBPhenotype:0000497 ! organism_gamma_ray_response_abnormal is_a: WBPhenotype:0000711 ! organism_hypersensitive_ionizing_radiation [Term] id: WBPhenotype:0001389 name: cell_gamma_ray_resistant is_a: WBPhenotype:0001326 ! cell_gamma_ray_response_abnormal [Term] id: WBPhenotype:0001390 name: cell_UV_hypersensitive is_a: WBPhenotype:0000100 ! cell_UV_response_abnormal [Term] id: WBPhenotype:0001391 name: gamma_ray_induced_apoptosis_increased is_a: WBPhenotype:0000183 ! apoptosis_increased is_a: WBPhenotype:0001326 ! cell_gamma_ray_response_abnormal [Term] id: WBPhenotype:0001392 name: cell_cycle_arrest is_a: WBPhenotype:0000740 ! cell_cycle_abnormal [Term] id: WBPhenotype:0001393 name: cell_acidification_abnormal is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0001394 name: cell_acidification_defective synonym: "no_pumping" RELATED [] is_a: WBPhenotype:0001393 ! cell_acidification_abnormal [Term] id: WBPhenotype:0001395 name: body_vacuole is_a: WBPhenotype:0000072 ! body_morphology_abnormal [Term] id: WBPhenotype:0001396 name: pumping_absent def: "Animals completely lack any pharyngeal pumping motion." [WB:WBPaper00001894, WB:WBPerson2021] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_abnormal [Term] id: WBPhenotype:0001397 name: necrotic_cell_death_increased is_a: WBPhenotype:0000415 ! necrotic_cell_death_abnormal [Term] id: WBPhenotype:0001398 name: neurite_morphology_abnormal def: "Animals display deviations in the structure, organization of components, or spatial pattern of any projection stemming from a neuronal cell, compared to that observed in normal animals. " [GO:0043005, WB:WBPaper00028886, WB:WBPerson712] is_a: WBPhenotype:0000905 ! neuron_morphology_abnormal [Term] id: WBPhenotype:0001399 name: cell_membrane_morphology_abnormal is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0001400 name: level_of_protein_expression_abnormal is_a: WBPhenotype:0000112 ! protein_expression_abnormal [Term] id: WBPhenotype:0001401 name: mitochondria_morphology_abnormal def: "The morphological appearance of mitochondrial cells is abnormal compared to wild type." [WB:cab] is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0001402 name: connected_mitochondria is_a: WBPhenotype:0001401 ! mitochondria_morphology_abnormal [Term] id: WBPhenotype:0001403 name: antibody_subcellular_localization_abnormal is_a: WBPhenotype:0000424 ! antibody_staining_abnormal [Term] id: WBPhenotype:0001404 name: ectopic_expression_antibody is_a: WBPhenotype:0000424 ! antibody_staining_abnormal [Term] id: WBPhenotype:0001405 name: protein_aggregation_abnormal is_a: WBPhenotype:0001370 ! protein_protein_interaction_abnormal [Term] id: WBPhenotype:0001406 name: protein_expression_reduced_male is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0001407 name: protein_expression_reduced_cell_specific is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0001408 name: pattern_protein_expression_abnormal is_a: WBPhenotype:0000112 ! protein_expression_abnormal [Term] id: WBPhenotype:0001409 name: protein_expression_ectopic is_a: WBPhenotype:0001408 ! pattern_protein_expression_abnormal [Term] id: WBPhenotype:0001410 name: protein_expression_absent is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0001411 name: cuticle_carbohydrate_surface_abnormal def: "Animals exhibit an altered display of glycosylated proteins or lipids or altered access to glycosylated moieties along their surface from that observed in normal animals of the same developmental stage. Alterations in surface accessible glycosylated species are often revealed by altered lectin-binding from that observed in normal animals. " [WB:WBPaper00001576, WB:WBPerson712] synonym: "ectopic_lectin_binding" RELATED [] synonym: "Srf" NARROW [] is_a: WBPhenotype:0001687 ! surface_antigenicity_abnormal [Term] id: WBPhenotype:0001412 name: alae_morphology_abnormal def: "Animals exhibit deviations in the organization of the longitudinal ridges deposited by seam cells on the cuticle along the length of the animal, from that observed for normal animals of the same developmental stage. " [WB:WBPaper00000465, WB:WBPaper00031415, WB:WBPerson712] relationship: part_of WBPhenotype:0000948 ! cuticle_morphology_abnormal [Term] id: WBPhenotype:0001413 name: bacterially_unswollen def: "Mutants do not exhibit tail-swelling in response to infection by the bacterial nematode-specific pathogen, Microbacterium nematophilum, that colonizes the rectum." [WB:cab, WB:WBPaper00026735] synonym: "Bus" BROAD three_letter_name [] is_a: WBPhenotype:0000073 ! tail_morphology_abnormal is_a: WBPhenotype:0001014 ! pathogen_resistance_increased [Term] id: WBPhenotype:0001414 name: male_mating_defective is_a: WBPhenotype:0000648 ! male_mating_abnormal [Term] id: WBPhenotype:0001415 name: pathogen_adherence_abnormal def: "Due to a possible defect in the surface of the worm, a pathogen is not able to adhere to the surface and infect the worm." [WB:cab, WB:WBPaper00026735] is_a: WBPhenotype:0001012 ! organism_pathogen_response_abnormal [Term] id: WBPhenotype:0001416 name: pathogen_adherence_defect is_a: WBPhenotype:0001014 ! pathogen_resistance_increased is_a: WBPhenotype:0001415 ! pathogen_adherence_abnormal [Term] id: WBPhenotype:0001417 name: organism_dessication_response_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0001418 name: organism_hypersensitive_dessication is_a: WBPhenotype:0001417 ! organism_dessication_response_abnormal [Term] id: WBPhenotype:0001419 name: emetine_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0001420 name: biofilm_absent_head def: "Inability of a biofilm to attach to the head of the mutant worm. A biofilm is a population of adherent bacteria enclosed by a matrix. When C. elegans is exposed to certain bacteria ( e.g., Y. pestis), a biofilm forms on a worm's head. The presence of this biofilm inhibits feeding by the worm, and thereby prevents growth." [WB:cab, WB:WBPaper00005238] synonym: "Bah" BROAD three_letter_name [] is_a: WBPhenotype:0001415 ! pathogen_adherence_abnormal [Term] id: WBPhenotype:0001421 name: endocytic_transport_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0001422 name: endocytic_transport_defect is_a: WBPhenotype:0001421 ! endocytic_transport_abnormal [Term] id: WBPhenotype:0001423 name: coelomocyte_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0001424 name: oocyte_physiology_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0001425 name: receptor_mediated_endocytosis_defective def: "Receptor-mediated uptake of yolk in oocytes is defective compared with wild type." [pmid:16042554, WB:cab] synonym: "Rme" RELATED [] is_a: WBPhenotype:0001422 ! endocytic_transport_defect is_a: WBPhenotype:0001424 ! oocyte_physiology_abnormal [Term] id: WBPhenotype:0001426 name: coelomocyte_uptake_defective def: "Fluid-phase endocytosis by coelomocytes is defective." [pmid:16042554, WB:cab] synonym: "Cup" RELATED [] is_a: WBPhenotype:0001422 ! endocytic_transport_defect is_a: WBPhenotype:0001423 ! coelomocyte_physiology_abnormal [Term] id: WBPhenotype:0001427 name: cytoplasmic_appearance_abnormal is_a: WBPhenotype:0010002 ! cell_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001428 name: intestinal_vacuole is_a: WBPhenotype:0000710 ! intestinal_morphology_abnormal [Term] id: WBPhenotype:0001429 name: granules_cytoplasm def: "Mutants accumulate vesicle-like structures." [pmid:17203072, WB:cab] is_a: WBPhenotype:0001427 ! cytoplasmic_appearance_abnormal [Term] id: WBPhenotype:0001430 name: lysosome_organization_biogenesis_abnormal is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0001431 name: pointed_tail_tip_male synonym: "Lep" BROAD three_letter_name [] synonym: "leptoderan_tail" RELATED [] is_a: WBPhenotype:0000070 ! male_tail_morphology_abnormal [Term] id: WBPhenotype:0001432 name: over_retracted_male_tail def: "Due to precocious male tail tip retraction beginning in the early L3 stage (normally retraction begins in the L4 stage), some adult males exhibit a severely truncated tail, often without a fan. Other males have well-developed fans but squarish, truncated back ends. Condition can be lethal if the function of the anus is affected." [pmid:16806150, WB:cab] synonym: "Ore" BROAD three_letter_name [] is_a: WBPhenotype:0000070 ! male_tail_morphology_abnormal is_a: WBPhenotype:0001297 ! male_tail_development_abnormal [Term] id: WBPhenotype:0001433 name: precocious_cell_fusion is_a: WBPhenotype:0000165 ! cell_fusion_abnormal [Term] id: WBPhenotype:0001434 name: chemotaxis_abnormal def: "The directed movement of a worm in response to a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GO:0006935, WB:cab] is_a: WBPhenotype:0001040 ! chemosensory_response_abnormal [Term] id: WBPhenotype:0001435 name: ammonium_chloride_chemotaxis_defective def: "Failure to move towards attractive concentrations of ammonium chloride (WBPaper00002087). NH4Cl has also subsequently been used to assay for Cl- attraction (WBPaper00026812, WBPaper00004609)." [WB:WBPaper00002087, WB:WBPaper00004609, WB:WBPaper00026812] synonym: "chloride chemotaxis defective" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001460 ! ammonium_chloride_chemotaxis_abnormal [Term] id: WBPhenotype:0001436 name: nose_touch_hypersensitive def: "Animals initiate backward movement more often, compared to normal, after nose-on collisions with an object. The nose is the anterior most tip of the animal." [WB:WBPaper00028963, WB:WBPerson557] is_a: WBPhenotype:0004026 ! nose_touch_abnormal [Term] id: WBPhenotype:0001437 name: octanol_chemotaxis_hypersensitive def: "Animals execute a more rapid avoidance response to dilute concentrations of octanol, compared to wild-type." [WB:WBPaper00028963] is_a: WBPhenotype:0001452 ! octanol_chemotaxis_abnormal [Term] id: WBPhenotype:0001438 name: odorant_positive_chemotaxis_defective def: "Failure to move towards typically attractive volatile organic molecules, sensed by the AWA and AWC neurons." [WB:WBPerson2021] is_a: WBPhenotype:0000015 ! positive_chemotaxis_defective is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001439 name: anion_positive_chemotaxis_defective def: "Failure to move towards typically attractive anions." [WB:WBPaper00002033, WB:WBPaper00028386] is_a: WBPhenotype:0001052 ! anion_positive_chemotaxis_abnormal is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective [Term] id: WBPhenotype:0001440 name: cation_positive_chemotaxis_defective def: "Failure to move towards typically attractive cations." [WB:WBPaper00004609] is_a: WBPhenotype:0001051 ! cation_positive_chemotaxis_abnormal is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective [Term] id: WBPhenotype:0001441 name: aqueous_positive_chemotaxis_defective def: "Failure to move towards typically attractive water-soluble chemicals." [WB:WBPerson2021] synonym: "water_soluble_positive_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000015 ! positive_chemotaxis_defective is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001442 name: sodium_acetate_chemotaxis_defective def: "Failure to move towards attractive concentrations of sodium acetate (WBPaper00006394). Sodium acetate has also subsequently been used to assay for Na+ attraction (WBPaper00000650, WBPaper00004609). \n" [WB:WBPaper00000650, WB:WBPaper00004609, WB:WBPaper00006394] synonym: "sodium chemotaxis defective" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001461 ! sodium_acetate_chemotaxis_abnormal [Term] id: WBPhenotype:0001443 name: aqueous_chemosensory_response_abnormal def: "Chemosensory response to water-soluble compounds is altered." [WB:cab] synonym: "water_soluble_chemosensory_response_abnormal" RELATED [] is_a: WBPhenotype:0001040 ! chemosensory_response_abnormal [Term] id: WBPhenotype:0001444 name: aqueous_adaptation_abnormal def: "Mutant animals do not exhibit characteristic desensitization to a water-soluble chemo-attractive signal in a time-concentration dependent and reversible manner." [WB:cab, WB:cgc5150] synonym: "gustatory_plasticity_abnormal" RELATED [] synonym: "water_soluble_adaptation_abnormal" RELATED [] is_a: WBPhenotype:0001443 ! aqueous_chemosensory_response_abnormal [Term] id: WBPhenotype:0001445 name: sodium_acetate_adaptation_abnormal def: "Mutant animals do not exhibit characteristic chemoattractive desensitization to sodium acetate in a time-concentration dependent and reversible manner." [WB:cab, WB:cgc5150] is_a: WBPhenotype:0001444 ! aqueous_adaptation_abnormal [Term] id: WBPhenotype:0001446 name: sodium_chloride_adaptation_abnormal def: "Mutant animals do not exhibit characteristic chemoattractive desensitization to sodium chloride in a time-concentration dependent and reversible manner." [WB:cab, WB:cgc5150] is_a: WBPhenotype:0001444 ! aqueous_adaptation_abnormal [Term] id: WBPhenotype:0001447 name: ammonium_chloride_adaptation_abnormal def: "Mutant animals do not exhibit characteristic chemoattractive desensitization to ammonium chloride in a time-concentration dependent and reversible manner." [WB:cab, WB:cgc5150] is_a: WBPhenotype:0001444 ! aqueous_adaptation_abnormal [Term] id: WBPhenotype:0001448 name: odorant_negative_chemotaxis_defective def: "Failure to avoid typically repellent volatile organic chemicals." [WB:WBPerson2021] synonym: "volatile_negative_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001455 ! odorant_negative_chemotaxis_abnormal [Term] id: WBPhenotype:0001449 name: aqueous_negative_chemotaxis_defective def: "Failure to avoid typically repellent water soluble chemicals." [WB:WBPerson2021] synonym: "water_soluble_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001450 ! aqueous_negative_chemotaxis_abnormal [Term] id: WBPhenotype:0001450 name: aqueous_negative_chemotaxis_abnormal def: "The characteristic tendency of animals to avoid typically repellent water soluble chemicals is altered." [WB:WBPaper00006481] synonym: "water_soluble_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000481 ! negative_chemotaxis_abnormal is_a: WBPhenotype:0001443 ! aqueous_chemosensory_response_abnormal [Term] id: WBPhenotype:0001451 name: garlic_chemotaxis_abnormal def: "Any alteration in the characteristic avoidance response to garlic, a water soluble repellent." [WB:WBPaper00002135, WB:WBPaper00006481] is_a: WBPhenotype:0001450 ! aqueous_negative_chemotaxis_abnormal [Term] id: WBPhenotype:0001452 name: octanol_chemotaxis_abnormal def: "Any alteration in the characteristic avoidance response to octanol." [WB:WBPerson2021] is_a: WBPhenotype:0001455 ! odorant_negative_chemotaxis_abnormal [Term] id: WBPhenotype:0001453 name: high_sodium_chloride_concentration_osmotic_avoidance_abnormal def: "Any alteration in the characteristic avoidance response to high concentrations of sodium chloride solution." [WB:WBPerson2021] is_a: WBPhenotype:0000249 ! osmotic_avoidance_defective [Term] id: WBPhenotype:0001454 name: quinine_chemotaxis_abnormal def: "Any alteration in the characteristic avoidance response to quinine, a water soluble repellent." [WB:WBPaper00002135, WB:WBPaper00027118] is_a: WBPhenotype:0001450 ! aqueous_negative_chemotaxis_abnormal [Term] id: WBPhenotype:0001455 name: odorant_negative_chemotaxis_abnormal def: "The characteristic tendency of animals to avoid typically repellent volatile organic chemicals is altered." [WB:WBPaper00001786] synonym: "volatile_negative_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000481 ! negative_chemotaxis_abnormal is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_abnormal [Term] id: WBPhenotype:0001456 name: nonanone_chemotaxis_abnormal def: "Any alteration in the characteristic avoidance response to nonanone." [WB:WBPerson2021] is_a: WBPhenotype:0001455 ! odorant_negative_chemotaxis_abnormal [Term] id: WBPhenotype:0001457 name: bromide_chemotaxis_abnormal def: "Characteristic movement towards bromide is altered." [WB:WBPaper00000387] is_a: WBPhenotype:0001052 ! anion_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001458 name: chloride_chemotaxis_abnormal def: "Characteristic movement towards chloride is altered." [WB:WBPaper00000387] synonym: "ammonium chloride chemotaxis abnormal" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001052 ! anion_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001459 name: iodide_chemotaxis_abnormal def: "Characteristic movement towards iodide is altered." [WB:WBPaper00000387] is_a: WBPhenotype:0001052 ! anion_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001460 name: ammonium_chloride_chemotaxis_abnormal def: "Characteristic movement towards attractive concentrations of ammonium chloride is altered (WBPaper00000387). NH4Cl has also subsequently been used to assay for Cl- attraction: WBPaper00026812, WBPaper00004609." [WB:WBPaper00000387, WB:WBPaper00004609, WB:WBPaper00026812] synonym: "chloride chemotaxis abnormal" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001461 name: sodium_acetate_chemotaxis_abnormal def: "Characteristic movement towards attractive concentrations of sodium acetate is altered (WBPaper00000387). Sodium acetate has also subsequently been used to assay for Na+ attraction (WBPaper00000650, WBPaper00004609). " [WB:WBPaper00000387, WB:WBPaper00000650, WB:WBPaper00004609)] synonym: " sodium chemotaxis abnormal" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001462 name: sodium_chloride_chemotaxis_abnormal def: "Characteristic movement towards attractive concentrations of sodium chloride is altered." [WB:WBPaper00000387] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001463 name: cAMP_chemotaxis_abnormal def: "Characteristic movement towards cAMP is altered." [WB:WBPaper00000387] is_a: WBPhenotype:0001053 ! cyclic_nucleotide_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001464 name: cGMP_chemotaxis_abnormal def: "Characteristic movement towards cGMP is altered. " [WB:WBPaper00000387] is_a: WBPhenotype:0001053 ! cyclic_nucleotide_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001465 name: acetone_chemotaxis_abnormal def: " Characteristic movement towards typically attractive concentrations of acetone is altered." [WB:WBPerson2021] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001466 name: AWA_odorant_chemotaxis_abnormal synonym: "AWA_volatile_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001467 name: AWC_odorant_chemotaxis_abnormal synonym: "AWC_volatile_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001468 name: benzaldehyde_chemotaxis_abnormal def: "Characteristic movement towards typically attractive concentrations of benzaldehyde is altered." [WB:WBPerson2021] is_a: WBPhenotype:0001467 ! AWC_odorant_chemotaxis_abnormal [Term] id: WBPhenotype:0001469 name: butanone_chemotaxis_abnormal def: "Characteristic movement towards typically attractive concentrations of butanone is altered." [WB:WBPerson2021] is_a: WBPhenotype:0001467 ! AWC_odorant_chemotaxis_abnormal [Term] id: WBPhenotype:0001470 name: diacetyl_chemotaxis_abnormal def: "Characteristic movement towards typically attractive concentrations of diacetyl is altered." [WB:WBPerson2021] is_a: WBPhenotype:0001466 ! AWA_odorant_chemotaxis_abnormal [Term] id: WBPhenotype:0001471 name: hexanol_chemotaxis_abnormal def: "Characteristic movement towards typically attractive concentrations of hexanol is altered." [WB:WBPerson2021] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001472 name: isoamyl_alcohol_chemotaxis_abnormal def: "Characteristic movement towards typically attractive concentrations of isoamyl alcohol is altered." [WB:WBPerson2021] is_a: WBPhenotype:0001467 ! AWC_odorant_chemotaxis_abnormal [Term] id: WBPhenotype:0001473 name: pentanol_chemotaxis_abnormal def: "Characteristic movement towards typically attractive concentrations of pentanol is altered." [WB:WBPerson2021] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001474 name: pyrazine_chemotaxis_abnormal def: "Characteristic movement towards typically attractive concentrations of pyrazine is altered." [WB:WBPerson2021] is_a: WBPhenotype:0001466 ! AWA_odorant_chemotaxis_abnormal [Term] id: WBPhenotype:0001475 name: trimethylthiazole_chemotaxis_abnormal def: "Characteristic movement towards typically attractive concentrations of trimethylthiazole is altered." [WB:WBPerson2021] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_abnormal [Term] id: WBPhenotype:0001476 name: anterior_body_contraction_abnormal is_a: WBPhenotype:0000210 ! defecation_contraction_abnormal [Term] id: WBPhenotype:0001477 name: anterograde_transport_abnormal is_a: WBPhenotype:0000854 ! intraflagellar_transport_defective [Term] id: WBPhenotype:0001478 name: body_elongation_abnormal is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0001479 name: dauer_pheromone_sensation_abnormal is_a: WBPhenotype:0001539 ! dauer_induction_abnormal [Term] id: WBPhenotype:0001480 name: grinder_relaxation_abnormal relationship: part_of WBPhenotype:0000336 ! terminal_bulb_relaxation_abnormal [Term] id: WBPhenotype:0001481 name: thrashing_increased is_a: WBPhenotype:0001700 ! swimming_abnormal [Term] id: WBPhenotype:0001482 name: frequency_body_bend_reduced is_a: WBPhenotype:0001213 ! locomotion_reduced is_a: WBPhenotype:0004023 ! frequency_of_body_bend_abnormal [Term] id: WBPhenotype:0001483 name: late_stage_egg_laid is_a: WBPhenotype:0000545 ! egg_retention [Term] id: WBPhenotype:0001484 name: ammonium_acetate_chemotaxis_defective def: "Failure to move towards attractive concentrations of ammonium acetate. " [WB:WBPaper00004136] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective [Term] id: WBPhenotype:0001485 name: ER_stress_response_abnormal synonym: "endoplasmic_reticulum_stress_response_abnormal" RELATED [] is_a: WBPhenotype:0000142 ! cell_stress_response_abnormal [Term] id: WBPhenotype:0001486 name: unfolded_protein_accumulation is_a: WBPhenotype:0001485 ! ER_stress_response_abnormal [Term] id: WBPhenotype:0001487 name: male_spicule_development_abnormal def: "Abnormal development of the male spicule that can result in its abnormal function or morphology.\n" [WB:cab, WB:WBPerson363] is_a: WBPhenotype:0000430 ! male_copulatory_structure_development_abnormal [Term] id: WBPhenotype:0001488 name: gubernaculum_development_abnormal def: "Abnormal development of the gubernaculum that results in its abnormal function or morphology." [WB:cab, WB:WBPerson363] relationship: part_of WBPhenotype:0001367 ! proctodeum_development_abnormal [Term] id: WBPhenotype:0001489 name: gubernaculum_morphology_abnormal def: "Animals exhibit deviations in the structure or composition of the sclerotic cuticle that forms the roof of the proctodeum, from that observed in normal animals." [WB:cab, WB:WBPaper00027278, WB:WBPerson363, WB:WBPerson712] relationship: part_of WBPhenotype:0001359 ! proctodeum_morphology_abnormal [Term] id: WBPhenotype:0001490 name: posterior_region_morphology_abnormal is_a: WBPhenotype:0000581 ! body_axis_morphology_abnormal [Term] id: WBPhenotype:0001491 name: anterior_region_morphology_abnormal is_a: WBPhenotype:0000581 ! body_axis_morphology_abnormal [Term] id: WBPhenotype:0001492 name: no_back_end def: "Mutants exhibit a severely deformed posterior region with a variable knob-like shape; accompanied by arrest at about the time of hatching with fairly normal pharyngeal and anterior development. Most mutants arrest as L1 larvae, and 5% do not hatch." [WB:cab, WB:cgc4499] synonym: "Nob" BROAD three_letter_name [] is_a: WBPhenotype:0000081 ! L1_arrest is_a: WBPhenotype:0000800 ! posterior_region_development_abnormal is_a: WBPhenotype:0000867 ! embryonic_arrest is_a: WBPhenotype:0001490 ! posterior_region_morphology_abnormal [Term] id: WBPhenotype:0001493 name: VPC_cell_division_precocious def: "VPCs (vulval precursor cells) divide at an earlier stage of development compared to wild type; in wild type, VPCs divide in the mid-L3 stage to generate the 22 cells that comprise the vulva." [pmid:16300753, WB:cab] is_a: WBPhenotype:0001495 ! cell_division_precocious [Term] id: WBPhenotype:0001494 name: distal_tip_cell_migration_precocious def: "Abnormally early migration of the DTCs at any point during their stereotypical migration pattern during development. " [pmid:16300753, WB:cab] is_a: WBPhenotype:0000195 ! distal_tip_cell_migration_abnormal [Term] id: WBPhenotype:0001495 name: cell_division_precocious def: "Cells divide at an earlier stage of development compared to wild-type animals." [WB:cab] is_a: WBPhenotype:0000345 ! VPC_cell_division_abnormal [Term] id: WBPhenotype:0001496 name: metaphase_to_anaphase_transition_defect is_a: WBPhenotype:0000740 ! cell_cycle_abnormal [Term] id: WBPhenotype:0001497 name: mitotic_metaphase_to_anaphase_transition_defect is_a: WBPhenotype:0001496 ! metaphase_to_anaphase_transition_defect [Term] id: WBPhenotype:0001498 name: sperm_pseudopod_physiology_abnormal is_a: WBPhenotype:0000987 ! germ_cell_physiology_abnormal [Term] id: WBPhenotype:0001499 name: meiotic_chromosome_segregation_abnormal is_a: WBPhenotype:0000773 ! chromosome_segregation_abnormal [Term] id: WBPhenotype:0001500 name: pentanedione_chemotaxis_abnormal def: "Chemotaxis to 2,3-pentanedione is abnormal." [WB:cab, WB:cgc2931] is_a: WBPhenotype:0001467 ! AWC_odorant_chemotaxis_abnormal [Term] id: WBPhenotype:0001501 name: odorant_discrimination_abnormal def: "Worms are defective in the discrimination of two distinct odorants." [WB:cab] is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_abnormal [Term] id: WBPhenotype:0001502 name: chemical_resistant is_a: WBPhenotype:0000523 ! chemical_response_abnormal [Term] id: WBPhenotype:0001503 name: ventral_nerve_cord_maintenance_abnormal def: "An abnormality in the mechanisms used to ensure that axons in the ventral nerve cord maintain their correct positioning after termination of axonal outgrowth and target recognition." [WB:WBPaper00005064, WB:WBPerson557] is_a: WBPhenotype:0000515 ! ventral_nerve_cord_development_abnormal [Term] id: WBPhenotype:0001504 name: maternal_effect_sterile def: "Sterility caused by aberrant maternal components required for normal postembryonic development and/or function of the germ line." [WB:WBPaper00001477] synonym: "Mes" BROAD three_letter_name [] is_a: WBPhenotype:0001037 ! sterile_progeny [Term] id: WBPhenotype:0001505 name: spontaneous_reversal_abnormal def: "Any abnormality in the processes that govern spontaneous backward locomotion." [WB:WBPaper00001311, WB:WBPerson557] is_a: WBPhenotype:0001702 ! directionality_abnormal [Term] id: WBPhenotype:0001506 name: spontaneous_reversal_rate_abnormal def: "Any abnormality in the processes that govern the rate at which spontaneous backward locomotion is initiated. Normal animals moving forward consistently initiate backward locomotion approximately 10 times per 3 minutes." [WB:WBPaper00001311, WB:WBPaper00026650, WB:WBPerson557] is_a: WBPhenotype:0001505 ! spontaneous_reversal_abnormal [Term] id: WBPhenotype:0001507 name: Bacillus_thuringiensis_toxin_resistant def: "A change in state or activity of a cell or an organism (in terms of secretion, enzyme production, gene expression, etc.) that results in resistance to toxins from Bacillus thuringiensis (Bt toxins)." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001508 name: anchor_cell_fusion_abnormal is_a: WBPhenotype:0000165 ! cell_fusion_abnormal [Term] id: WBPhenotype:0001509 name: rays_missing is_a: WBPhenotype:0000505 ! male_ray_morphology_abnormal [Term] id: WBPhenotype:0001510 name: neuronal_cell_fate_specification_abnormal def: "Any aberrancy in the processes that govern acquisition of neuronal cell fates." [WB:WBPerson2021] is_a: WBPhenotype:0000216 ! cell_fate_specification_abnormal [Term] id: WBPhenotype:0001511 name: linker_cell_migration_abnormal def: "Any alteration in the stereotypical migration pattern of the linker cell in a developing male." [WB:WBPaper00028966, WB:WBPerson2021] is_a: WBPhenotype:0000594 ! cell_migration_abnormal [Term] id: WBPhenotype:0001512 name: loss_of_left_right_neuronal_asymmetry def: "Bilaterally symmetric neurons fail to acquire specific left-right asymmetric properties such as L/R specific cell position, cell death or gene expression." [WB:WBPerson2021] is_a: WBPhenotype:0001510 ! neuronal_cell_fate_specification_abnormal [Term] id: WBPhenotype:0001513 name: dense_core_vesicle_exocytosis_abnormal is_a: WBPhenotype:0000728 ! exocytosis_abnormal [Term] id: WBPhenotype:0001514 name: synaptic_vesicle_endocytosis_abnormal is_a: WBPhenotype:0001422 ! endocytic_transport_defect is_a: WBPhenotype:0001684 ! synaptic_vesicle_homeostasis_abnormal [Term] id: WBPhenotype:0001515 name: struts_abnormal def: "Animals exhibit deviations in the quantity or patterning of electron-dense columnar structures that join the basal and cortical cuticle layers, from that observed in normal animals." [WB:WBPaper00000465, WB:WBPerson712] is_a: WBPhenotype:0000948 ! cuticle_morphology_abnormal [Term] id: WBPhenotype:0001516 name: cuticle_helicity_abnormal def: "Animals exhibit a helically twisted cuticle, which is not a trait exhibited by normal animals. In practice the degree of twisting is measured as the number of helical twists the alae make about anterior/posterior axis of the animal. " [WB:WBPaper00000465, WB:WBPerson712] is_a: WBPhenotype:0000948 ! cuticle_morphology_abnormal [Term] id: WBPhenotype:0001517 name: annulae_morphology_abnormal def: "Animals exhibit deviations in the circumferential pattern of ridges in the outer cortical layer of the cuticle, compared to that observed in normal animals of the same developmental stage." [WB:WBPaper00000465, WB:WBPaper00031415, WB:WBPerson712] is_a: WBPhenotype:0000948 ! cuticle_morphology_abnormal [Term] id: WBPhenotype:0001518 name: biogenic_amine_physiology_abnormal def: "Non-WT levels and/or localization of biogenic amines." [WB:WBPaper00000365] synonym: "FIF" BROAD three_letter_name [] synonym: "Formaldehyde_induced_fluorescence_abnormal " RELATED [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0001519 name: abnormal_posterior_cell_migration def: "The orderly movement of cells along the posterior axis of the animal is perturbed (abolished, misdirected or incomplete)." [WB:WBPerson2021] is_a: WBPhenotype:0000594 ! cell_migration_abnormal [Term] id: WBPhenotype:0001520 name: abnormal_posterior_neuron_migration def: "The orderly movement of neurons along the posterior axis of the animal is perturbed (abolished, misdirected or incomplete)." [WB:WBPerson2021] is_a: WBPhenotype:0001140 ! neuron_migration_abnormal [Term] id: WBPhenotype:0001521 name: body_elongation_retracted def: "Embryos retract after a normal or abnormal elongation process. " [WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0001522 name: spicules_protrude is_a: WBPhenotype:0000908 ! cloacal_morphology_abnormal [Term] id: WBPhenotype:0001523 name: extracellular_matrix_abnormal def: "Extracellular matrix (ECM) is altered in makeup, density or area compared to wild-type ECM. " [WB:WBPerson712] is_a: WBPhenotype:0000912 ! pericellular_component_morphology_abnormal [Term] id: WBPhenotype:0001524 name: quiescence_abnormal def: "Exhibition of quiescent behavior under inappropriate conditions and improper recovery from quiescent state. Quiescent behavior is normally coupled with lethargus." [WB:WBPerson2021] is_a: WBPhenotype:0000525 ! organism_behavior_abnormal [Term] id: WBPhenotype:0001525 name: terminal_bulb_morphology_abnormal def: "Any observed morphological defects of the terminal bulb." [WB:WBPerson2021] is_a: WBPhenotype:0000709 ! pharyngeal_morphology_abnormal [Term] id: WBPhenotype:0001526 name: ciliated_neuron_morphology_abnormal def: "Animals exhibit abnormalities in the structure or organization of any one of the specialized sensory receptor cells of the nervous system that are characterized in normal animals as having axoneme containing dendritic projections emanating from their cell body." [WB:WBbt\:0006816, WB:WBPaper00000503, WB:WBPaper00029016, WB:WBPerson712] is_a: WBPhenotype:0000299 ! sensillum_morphology_abnormal [Term] id: WBPhenotype:0001527 name: amphid_phasmid_sensillum_morphology_abnormal def: "Animals exhibit abnormalities in the quantity, structure or organization of any component of any one of the bilaterally symmetric specialized chemosensory organs located on the two lateral lips in the head (amphids) or along the tail (phasmids), compared to that observed in normal animals." [WB:WBbt\:0005391, WB:WBbt\:0005425] is_a: WBPhenotype:0000299 ! sensillum_morphology_abnormal [Term] id: WBPhenotype:0001528 name: sensillum_accessory_cell_morphology_abnormal def: "the sheath and or socket cells of the sensillum are abnormal in channel formation, morphology or their junctions with each other, channel neurons or surrounding epithelia." [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000299 ! sensillum_morphology_abnormal [Term] id: WBPhenotype:0001529 name: sensilium_sheath_cell_abnormal is_a: WBPhenotype:0001528 ! sensillum_accessory_cell_morphology_abnormal [Term] id: WBPhenotype:0001530 name: cephalic_sensillum_morphology_abnormal def: "Animals exhibit abnormalities in the quantity, structure or organization of any component of either bilaterally located specialized sensory organ in the head that contains a CEP receptor neuron. In normal animals, cells in these organs are refractory to FITC dye uptake." [WB:WBbt\:0006920, WB:WBPaper00000214, WB:WBPaper00000503, WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000299 ! sensillum_morphology_abnormal [Term] id: WBPhenotype:0001531 name: labial_sensillum_morphology_abnormal def: "Animals exhibit deviations in the quantity, structure or organization of the sensilla of the head that are arranged in two (inner and outer) concentric rings around the mouth, from that observed in normal animals. " [WB:WBPaper00000214, WB:WBPaper00000938, WB:WBPerson712] is_a: WBPhenotype:0000299 ! sensillum_morphology_abnormal [Term] id: WBPhenotype:0001532 name: inner_labial_morphology_abnormal def: "Animals exhibit deviations in the quantity, structure or organization of the components of the inner ring of six sensilla, which include associated neurons IL1 & IL2, from that observed in normal animals. " [WB:WBPaper00000938, WB:WBPerson712] is_a: WBPhenotype:0001531 ! labial_sensillum_morphology_abnormal [Term] id: WBPhenotype:0001533 name: outer_labial_morphology_abnormal def: "Animals exhibit deviations in the quantity, structure or organization of the components of the outer ring of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum, from that observed in normal animals. " [WB:WBPaper00000938, WB:WBPerson712] is_a: WBPhenotype:0001531 ! labial_sensillum_morphology_abnormal [Term] id: WBPhenotype:0001534 name: neuronal_ECM_abnormal def: "The extracellular matrix (ECM),a pericellular organelle lending structure to neurons, is altered in makeup, density or area compared to ECM in normal animals. Neuronal ECM is sometimes referred to as a mantle." [WB:WBPaper00000502, WB:WBPerson712] is_a: WBPhenotype:0001523 ! extracellular_matrix_abnormal [Term] id: WBPhenotype:0001535 name: deirid_sensillum_morphology_abnormal def: "Animals exhibit deviations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal. In normal animals, each of the 4 deirid sensilla contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC." [WB:WBPaper00000938, WB:WBPaper00029016, WB:WBPerson712] is_a: WBPhenotype:0000299 ! sensillum_morphology_abnormal [Term] id: WBPhenotype:0001536 name: embryonic_cell_patterning_abnormal def: "Cell types differentiated, but not correctly patterned in the embryo." [WB:WBPerson557] is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0001537 name: mRNA_turnover_abnormal def: "Alteration in the ability of cells to monitor the quality of their mRNAs and degrade any transcripts that are poorly or incompletely translated." [WB:WBPaper00004926] is_a: WBPhenotype:0000028 ! RNA_processing_abnormal [Term] id: WBPhenotype:0001538 name: mRNA_surveillance_defective def: "Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. Mutations in such loci often act as allele specific non gene specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis on male and hermaphrodite genitalia." [WB:WBPaper00001192, WB:WBPaper00004926] synonym: "Smg" NARROW [] is_a: WBPhenotype:0000028 ! RNA_processing_abnormal [Term] id: WBPhenotype:0001539 name: dauer_induction_abnormal is_a: WBPhenotype:0000159 ! dauer_arrest_abnormal [Term] id: WBPhenotype:0001540 name: dauer_lifespan_abnormal is_a: WBPhenotype:0001547 ! dauer_metabolism_abnormal [Term] id: WBPhenotype:0001541 name: dauer_gonad_arrest_abnormal is_a: WBPhenotype:0000637 ! dauer_formation_abnormal [Term] id: WBPhenotype:0001542 name: dauer_feeding_suppressed_abnormal is_a: WBPhenotype:0001001 ! dauer_behavior_abnormal [Term] id: WBPhenotype:0001543 name: dauer_reduced_locomotion_abnormal is_a: WBPhenotype:0001001 ! dauer_behavior_abnormal [Term] id: WBPhenotype:0001544 name: dauer_sensory_response_abnormal is_a: WBPhenotype:0001001 ! dauer_behavior_abnormal [Term] id: WBPhenotype:0001545 name: dauer_body__morphology_abnormal is_a: WBPhenotype:0000934 ! developmental_morphology_abnormal [Term] id: WBPhenotype:0001546 name: dauer_resistance_to_harsh_conditions_abnormal is_a: WBPhenotype:0000159 ! dauer_arrest_abnormal [Term] id: WBPhenotype:0001547 name: dauer_metabolism_abnormal is_a: WBPhenotype:0000159 ! dauer_arrest_abnormal [Term] id: WBPhenotype:0001548 name: dauer_axial_ratio_abnormal is_a: WBPhenotype:0001545 ! dauer_body__morphology_abnormal [Term] id: WBPhenotype:0001549 name: dauer_gut_abnormal is_a: WBPhenotype:0001545 ! dauer_body__morphology_abnormal [Term] id: WBPhenotype:0001550 name: dauer_buccal_cavity_morphology_abnormal is_a: WBPhenotype:0001545 ! dauer_body__morphology_abnormal [Term] id: WBPhenotype:0001551 name: dauer_cuticle_abnormal is_a: WBPhenotype:0001545 ! dauer_body__morphology_abnormal [Term] id: WBPhenotype:0001552 name: dauer_pharynx_morphology_abnormal is_a: WBPhenotype:0001545 ! dauer_body__morphology_abnormal [Term] id: WBPhenotype:0001553 name: dauer_excretory_gland_abnormal is_a: WBPhenotype:0001545 ! dauer_body__morphology_abnormal [Term] id: WBPhenotype:0001554 name: dauer_nose_morphology_abnormal is_a: WBPhenotype:0001545 ! dauer_body__morphology_abnormal [Term] id: WBPhenotype:0001555 name: dauer_sensory_system_morphology_abnormal is_a: WBPhenotype:0001545 ! dauer_body__morphology_abnormal [Term] id: WBPhenotype:0001556 name: dauer_sensillum_abnormal is_a: WBPhenotype:0001555 ! dauer_sensory_system_morphology_abnormal [Term] id: WBPhenotype:0001557 name: dauer_labial_sensillum_abnormal is_a: WBPhenotype:0001556 ! dauer_sensillum_abnormal [Term] id: WBPhenotype:0001558 name: dauer_amphid_sensillum_abnormal is_a: WBPhenotype:0001556 ! dauer_sensillum_abnormal [Term] id: WBPhenotype:0001559 name: dauer_deirid_sensillum_abnormal is_a: WBPhenotype:0001556 ! dauer_sensillum_abnormal [Term] id: WBPhenotype:0001560 name: dauer_sensory_system_plug_abnormal is_obsolete: true [Term] id: WBPhenotype:0001561 name: dauer_inner_labial_sensillum_abnormal is_a: WBPhenotype:0001557 ! dauer_labial_sensillum_abnormal [Term] id: WBPhenotype:0001562 name: dauer_outer_labial_sensillum_abnormal is_a: WBPhenotype:0001557 ! dauer_labial_sensillum_abnormal [Term] id: WBPhenotype:0001563 name: dauer_cephalic_sensillum_abnormal is_a: WBPhenotype:0001556 ! dauer_sensillum_abnormal [Term] id: WBPhenotype:0001564 name: duration_of_self_fertility_abnormal def: "The window of production of self-fertilized eggs exceeds or does not extend to the normal length." [WB:WBPaper00002419, WB:WBPerson712] is_a: WBPhenotype:0000806 ! hermaphrodite_fertility_abnormal [Term] id: WBPhenotype:0001565 name: lysine_chemotaxis_defective def: "Failure to move towards lysine." [WB:WBPaper00001481, WB:WBPaper00001786, WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective [Term] id: WBPhenotype:0001566 name: ventral_enclosure_abnormal def: "The process that regulates the migration of ventral epidermal cells toward the ventral midline (to encase underlying cells in an epithelial monolayer) in developing embryos is perturbed." [WB:WBPaper00027244, WB:WBPerson2021] is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0001567 name: nuclei_enlarged is_a: WBPhenotype:0001028 ! nuclear_appearance_abnormal [Term] id: WBPhenotype:0001568 name: mRNA_export_abnormal def: "Export of mRNA from the cell nucleus is compromised." [WB:WBPaper00005960] is_a: WBPhenotype:0000114 ! mRNA_expression_abnormal is_a: WBPhenotype:0001706 ! nuclear_export_abnormal [Term] id: WBPhenotype:0001569 name: body_wall_muscle_myosin_organization_abnormal def: "The characteristic organization of myosin filaments into discrete A-bands within the muscle cells is disrupted. Myosin filaments no longer appear as continuous longitudinally oriented fibers across the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021] synonym: "body wall muscle thick myofilament organization abnormal" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0000926 ! body_wall_muscle_morphology_abnormal [Term] id: WBPhenotype:0001570 name: body_wall_muscle_actin_organization_abnormal def: "The characteristic organization of actin filaments into I-bands is disrupted. Actin filaments no longer appear as thin continuous longitudinal stripes along the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021] synonym: "body wall muscle thin myofilament organization abnormal" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0000926 ! body_wall_muscle_morphology_abnormal [Term] id: WBPhenotype:0001571 name: body_wall_muscle_cell_polarization_abnormal def: "Any alteration in the accumulation of muscle proteins at membranes where adjacent muscle cells contact each other and the hypodermis. During early embryonic body wall muscle development, muscle, basement membrane, and hypodermal components are all colocalized in a continuous linear structure at the site of muscle-hypodermal contact." [WB:WBPaper00001895] is_a: WBPhenotype:0000926 ! body_wall_muscle_morphology_abnormal [Term] id: WBPhenotype:0001572 name: masculinized def: "XX animals exhibit male-specific attributes" [WB:WBPaper00000178, WB:WBPaper00001206, WB:WBPerson712] is_a: WBPhenotype:0001022 ! hermaphrodite_sexual_development_abnormal [Term] id: WBPhenotype:0001573 name: nicotine_response_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0001574 name: ATP_levels_abnormal is_a: WBPhenotype:0000027 ! organism_metabolism_processing_abnormal [Term] id: WBPhenotype:0001575 name: ATP_levels_reduced is_a: WBPhenotype:0001574 ! ATP_levels_abnormal [Term] id: WBPhenotype:0001576 name: mitochondria_spacing_abnormal is_a: WBPhenotype:0001401 ! mitochondria_morphology_abnormal [Term] id: WBPhenotype:0001577 name: mitochondria_alignment_abnormal is_a: WBPhenotype:0001401 ! mitochondria_morphology_abnormal [Term] id: WBPhenotype:0001578 name: cholinergic_agonist_resistant is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001579 name: cholinergic_agonist_hypersensitive is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0001580 name: nuclear_envelope_breakdown_abnormal is_a: WBPhenotype:0001138 ! nucleus_abnormal_early_emb [Term] id: WBPhenotype:0001581 name: X_linked_gene_expression_enhanced def: "Levels of transcripts associated with genes on the X chromosome are increased compared to normal." [WB:WBPaper00001011, WB:WBPerson712] is_a: WBPhenotype:0000718 ! dosage_compensation_abnormal [Term] id: WBPhenotype:0001582 name: X_linked_gene_expression_reduced def: "Levels of transcripts associated with genes on the X chromosome are decreased compared to normal." [WB:WBPaper00001011, WB:WBPerson712] is_a: WBPhenotype:0000718 ! dosage_compensation_abnormal [Term] id: WBPhenotype:0001583 name: XXX_progeny def: "Animals segregate progeny with 3 X chromosomes." [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001584 name: chromosome_alignment_at_metaphase_plate_abnormal is_a: WBPhenotype:0000773 ! chromosome_segregation_abnormal [Term] id: WBPhenotype:0001585 name: asymmetric_cell_division_abnormal is_a: WBPhenotype:0001235 ! cell_division_polarity_abnormal [Term] id: WBPhenotype:0001586 name: multiple_anchor_cells def: "Presumptive ventral uterine cells undergo fate transformation and instead acquire the properties of an anchor cell (often due to defects in lateral signaling)." [WB:WBPaper00001423, WB:WBPerson2021] synonym: "double anchor cell" NARROW [] is_a: WBPhenotype:0000399 ! somatic_gonad_development_abnormal [Term] id: WBPhenotype:0001587 name: actin_organization_biogenesis_abnormal is_a: WBPhenotype:0001345 ! cytoskeleton_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001588 name: microtubule_organization_biogenesis_abnormal is_a: WBPhenotype:0001345 ! cytoskeleton_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001589 name: microtubule_nucleation_abnormal def: "Any abnormality that alters the characteristic de novo formation of a microtubule." [GO:0007020] is_a: WBPhenotype:0001588 ! microtubule_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001590 name: microtubule_depolymerization_abnormal def: "Any abnormality that alters the characteristic removal of tubulin heterodimers from one or both ends of a microtubule." [GO:0007019] is_a: WBPhenotype:0001588 ! microtubule_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001591 name: microtubule_polymerization_abnormal def: "Any abnormality that alters the characteristic addition of tubulin heterodimers to one or both ends of a microtubule. " [GO:0046785] is_a: WBPhenotype:0001588 ! microtubule_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001592 name: fainter def: "Alternating periods of stopping and moving; motion is normal when moving but interrupted by periods of inactivity lasting several seconds." [WB:WBPaper00031286] is_a: WBPhenotype:0001213 ! locomotion_reduced [Term] id: WBPhenotype:0001593 name: transgene_silencing_abnormal is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0001594 name: germline_transgene_silencing_abnormal is_a: WBPhenotype:0001593 ! transgene_silencing_abnormal [Term] id: WBPhenotype:0001595 name: somatic_transgene_silencing_abnormal is_a: WBPhenotype:0001593 ! transgene_silencing_abnormal [Term] id: WBPhenotype:0001596 name: tail_bobbed def: "Swelling of the hermaphrodite tail hypodermis resulting in a prematurely-truncated and thickened appearance of the tail." [WB:WBPaper00024194, WB:WBPerson712] is_a: WBPhenotype:0000073 ! tail_morphology_abnormal [Term] id: WBPhenotype:0001597 name: muscle_missing def: "Any abnormality that results in a fewer than wild-type number of muscle cells." [WB:WBPaper00001423, WB:WBPaper00002946, WB:WBPerson2021] is_a: WBPhenotype:0000622 ! muscle_system_development_abnormal [Term] id: WBPhenotype:0001598 name: inhibitor_of_serotonin_uptake_abnormal def: "Treatment with inhibitors of serotonin reuptake does not elicit the same response as observed for normal animals. " [WB:WBPerson712] is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0001599 name: ouabain_resistant def: "Animals are resistant to the physiological changes/effects caused by certain concentrations of ouabain, an inhibitor of sodium potassium ATPase. Resistance to ouabain is often assayed via body contraction response." [WB:WBPaper00000484, WB:WBPerson2021] is_a: WBPhenotype:0000331 ! inhibitors_of_na_k_atpase_resistant [Term] id: WBPhenotype:0001600 name: contraction_response_to_ouabain_resistant def: "Animals do not exhibit rapid muscular contractions in response to certain concentrations of ouabain, an inhibitor of sodium potassium ATPase. " [WB:WBPaper00000484] is_a: WBPhenotype:0001599 ! ouabain_resistant [Term] id: WBPhenotype:0001601 name: biogenic_amine_receptor_antagonist_resistant def: "Receptor antagonists block the action of biogenic amines such as serotonin or octopamine by binding to, but do not activating, the receptor." [WB:WBPerson712] synonym: "serotonin_receptor_antagonist" NARROW [] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001602 name: methiothepin_resistant def: "Animals have an altered response to methiothepin, which acts as a serotonin receptor antagonist." [WB:WBPaper00031241, WB:WBPerson721] is_a: WBPhenotype:0001601 ! biogenic_amine_receptor_antagonist_resistant [Term] id: WBPhenotype:0001603 name: cyproheptadine_resistant def: "Animals have an altered response to cyproheptadine, which acts as a serotonin receptor antagonist." [WB:WBPaper00031241, WB:WBPerson721] is_a: WBPhenotype:0001601 ! biogenic_amine_receptor_antagonist_resistant [Term] id: WBPhenotype:0001604 name: mianserin_resistant def: "Animals have an altered response to mianserin, which acts as a serotonin receptor antagonist." [WB:WBPaper00031241, WB:WBPerson721] synonym: "dibenzazepine_resistant" RELATED [] is_a: WBPhenotype:0001601 ! biogenic_amine_receptor_antagonist_resistant [Term] id: WBPhenotype:0001605 name: extended_life_span_response_to_mianserin_resistant def: "Animals do not live longer in response to mianserin." [WB:WBPaper00031241, WB:WBPerson721] is_a: WBPhenotype:0001604 ! mianserin_resistant [Term] id: WBPhenotype:0001606 name: ethanol_hypersensitive def: "Animals exhibit a response to the presence of ethanol under conditions when normal animals do not respond, for example responses may be exhibited within a shorter time of exposure, or at lower concentration of the alcohol." [WB:WBPaper00002358, WB:WBPerson712] synonym: "alcohol_sensistive" BROAD [] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001607 name: paralysis_response_to_ethanol_hypersensitive def: "Animals stop moving in the presence of ethanol under conditions when normal worms continue to move, for example paralysis occurs within a shorter time of exposure, or at a lower concentration of the alcohol." [WB:WBPaper00002358, WB:WBPerson712] is_a: WBPhenotype:0001606 ! ethanol_hypersensitive [Term] id: WBPhenotype:0001608 name: enflurane_hypersensitive def: "Animals exhibit a response to the anesthetic enflurane at lower concentrations or with quicker response times than normal animals." [WB:WBPaper00002037, WB:WBPerson721] synonym: "ether_hypersensitive" RELATED [] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001609 name: isoflurane_hypersensitive def: "Animals exhibit a response to the anesthetic isoflurane at lower concentrations or with quicker response times than normal animals. " [WB:WBPaper00002037, WB:WBPerson721] synonym: "ether_hypersensitive" RELATED [] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001610 name: diethyl_ether_hypersensitive def: "Animals exhibit a response to the anesthetic ether at lower concentrations or with quicker response times than normal animals." [WB:WBPaper00001063, WB:WBPaper00002037, WB:WBPerson721] synonym: "ether_hypersensitive" RELATED [] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001611 name: halothane_hypersensitive def: "Animals exhibit an altered to the lipid-soluble anesthetic halothane at lower concentrations or with quicker response times than normal animals." [WB:WBPaper00000958, WB:WBPaper00031286, WB:WBPerson721] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001612 name: ethanol_resistant def: "Animals do not exhibit a response to the presence of ethanol characteristic of normal animals, for example responses may not be exhibited within the same time period of exposure or at the same concentration of the alcohol." [WB:WBPaper00002358, WB:WBPaper00031371, WB:WBPerson712] synonym: "alcohol_resistant" BROAD [] synonym: "Jud" BROAD three_letter_name [] is_a: WBPhenotype:0000009 ! anesthetic_resistant [Term] id: WBPhenotype:0001613 name: paralysis_response_to_ethanol_resistant def: "Animals in the presence of alcohol continue to respond to touch under conditions when normal worms have stopped responding to stimuli." [WB:WBPaper00031371, WB:WBPerson712] is_a: WBPhenotype:0001612 ! ethanol_resistant [Term] id: WBPhenotype:0001614 name: anticonvulsant_response_abnormal is_a: WBPhenotype:0000631 ! drug_response_abnormal [Term] id: WBPhenotype:0001615 name: anticonvulsant_resistant def: "Animals do not exhibit a response to compounds that act as anticonvulsants. Alternatively, animals may take longer, or require higher concentrations of the anticonvulsant to exhibit a response. " [WB:WBPaper00024698, WB:WBPerson712] is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0001614 ! anticonvulsant_response_abnormal [Term] id: WBPhenotype:0001616 name: trimethadione_resistant def: "Animals do not exhibit a response to trimethadione, which acts as an anticonvulsant. Alternatively, animals may take longer, or require higher concentrations of the anticonvulsant to exhibit a response." [WB:WBPaper00024698, WB:WBPerson712] is_a: WBPhenotype:0001615 ! anticonvulsant_resistant [Term] id: WBPhenotype:0001617 name: ethosuximide_resistant def: "Animals do not exhibit a response to ethosuximide, which acts as an anticonvulsant. Alternatively, animals may take longer, or require higher concentrations of the anticonvulsant to exhibit a response." [WB:WBPerson712] is_a: WBPhenotype:0001615 ! anticonvulsant_resistant [Term] id: WBPhenotype:0001618 name: halothane_resistant def: "Animals do not respond to concentrations of the anesthetic halothane in a manner similar to normal animals." [WB:WBPaper00004721, WB:WBPerson712] is_a: WBPhenotype:0000009 ! anesthetic_resistant [Term] id: WBPhenotype:0001619 name: isoflurane_resistant def: "Animals do not respond to concentrations of the volatile anesthetic isoflurane in a manner similar to normal animals. " [WB:WBPaper00004721, WB:WBPerson712] is_a: WBPhenotype:0000009 ! anesthetic_resistant [Term] id: WBPhenotype:0001620 name: organism_oxidative_stress_response_abnormal is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0001621 name: organism_oxidative_stress_response_hypersensitive is_a: WBPhenotype:0001620 ! organism_oxidative_stress_response_abnormal [Term] id: WBPhenotype:0001622 name: egg_laying_serotonin_hypersensitive def: "Animals lay eggs at a greater rate in response to exogenous serotonin than normal animals." [WB:WBPaper00002487, WB:WBPerson712] is_a: WBPhenotype:0000023 ! serotonin_hypersensitive is_a: WBPhenotype:0001629 ! egg_laying_serotonin_abnormal [Term] id: WBPhenotype:0001623 name: male_tail_curling_serotonin_abnormal def: "The response of tight ventral curling of the male tail and posterior body in the presence of serotonin is not in manner similar to normal animals. " [WB:WBPaper00001861, WB:WBPerson557] is_a: WBPhenotype:0001232 ! serotonin_response_abnormal [Term] id: WBPhenotype:0001624 name: male_tail_curling_serotonin_resistant def: "The response of tight ventral curling of the male tail and posterior body in the presence of serotonin does not occur at the same to concentration as in normal animals." [WB:WBPaper00001861, WB:WBPerson557] is_a: WBPhenotype:0000024 ! serotonin_resistant is_a: WBPhenotype:0001623 ! male_tail_curling_serotonin_abnormal [Term] id: WBPhenotype:0001625 name: male_tail_curling_serotonin_hypersensitive def: "The response of tight ventral curling of the male tail and posterior body in the presence of serotonin occurs at lower concentrations then that ovserved in normal animals." [WB:WBPaper00001861, WB:WBPaper00028762, WB:WBPerson557] is_a: WBPhenotype:0000023 ! serotonin_hypersensitive is_a: WBPhenotype:0001623 ! male_tail_curling_serotonin_abnormal [Term] id: WBPhenotype:0001626 name: locomotion_rate_serotonin_abnormal def: "The change in locomotion rate in the presence of serotonin is not in manner similar to normal animals." [WB:WBPaper00002141] is_a: WBPhenotype:0001232 ! serotonin_response_abnormal [Term] id: WBPhenotype:0001627 name: locomotion_rate_serotonin_hypersensitive def: "The decrease in locomotion rate in the presence of serotonin is greater than normal animals." [WB:WBPaper00002141] synonym: "locomotion rate serotonin reduced" RELATED [] is_a: WBPhenotype:0000023 ! serotonin_hypersensitive is_a: WBPhenotype:0001626 ! locomotion_rate_serotonin_abnormal [Term] id: WBPhenotype:0001628 name: locomotion_rate_serotonin_resistant def: "The decrease in locomotion rate in the presence of serotonin is less than normal animals. " [WB:WBPaper00002141] synonym: "locomotion rate serotonin increased" RELATED [] is_a: WBPhenotype:0000024 ! serotonin_resistant is_a: WBPhenotype:0001626 ! locomotion_rate_serotonin_abnormal [Term] id: WBPhenotype:0001629 name: egg_laying_serotonin_abnormal def: "The characteristic response to exogenous serotonin is altered. Normal animals are induced to lay eggs in response to serotonin. " [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_abnormal is_a: WBPhenotype:0001232 ! serotonin_response_abnormal [Term] id: WBPhenotype:0001630 name: gut_obstructed synonym: "Gob" BROAD three_letter_name [] is_a: WBPhenotype:0000708 ! intestinal_development_abnormal [Term] id: WBPhenotype:0001631 name: nullo_X_gamete_abnormal def: "Animals produce ova/sperm that contain no X chromosome in a nonmendelian segregation pattern. " [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001632 name: diplo_X_gametes def: "Animals produce ova/sperm that contain 2 X chromosomes. " [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001633 name: lethal_gametes def: "Animals produce ova/sperm that contain lethal factors as a result of chromosomal disjunction defects. " [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001174 ! chromosome_disjunction_abnormal [Term] id: WBPhenotype:0001634 name: organism_electrophilic_stress_hypersenstive is_a: WBPhenotype:0000067 ! organism_stress_response_abnormal [Term] id: WBPhenotype:0001635 name: excess_pharyngeal_cells def: "Embryos generate an excess number of MS-like pharyngeal cells that are derived from the ABa, ABp, E or P2 blastomeres. The overproduction of pharyngeal tissue is often an outcome of multiple early blastomeres adopting a fate similar to that of the MS blastomere." [WB:WBPaper00001584, WB:WBPaper00002922, WB:WBperson2021] is_a: WBPhenotype:0000707 ! pharyngeal_development_abnormal [Term] id: WBPhenotype:0001636 name: excess_intestinal_cells def: "Embryos generate an excess number of intestinal cells that are derived from a non E-blastomere. For example, the P2 or MS blastomere adopts a fate that is similar to that of the E blastomere." [WB:WBPaper00001584, WB:WBPaper00002330, WB:WBperson2021] is_a: WBPhenotype:0000708 ! intestinal_development_abnormal [Term] id: WBPhenotype:0001637 name: no_Intestine def: "Embryos fail to generate the E blastomere-derived intestinal cells. (The E blastomere is the exclusive precursor of all the intestinal cells present in a wild-type embryo)." [WB:WBPaper00002946, WB:WBperson2021] is_a: WBPhenotype:0000708 ! intestinal_development_abnormal [Term] id: WBPhenotype:0001638 name: endosome_fusion_defective is_a: WBPhenotype:0001422 ! endocytic_transport_defect [Term] id: WBPhenotype:0001639 name: roaming_reduced def: "Animals do not move more than a few body lengths from their starting position, searches occur locally with pivoting behavior. " [WB:WBPaper00003743, WB:WBPaper00031455, WB:WBPerson712] synonym: "lurcher" RELATED [] is_a: WBPhenotype:0000238 ! foraging_reduced [Term] id: WBPhenotype:0001640 name: acidification_level_abnormal def: "Animals are unable to acidify compartments to the same level as that observed in normal animals given the same stimulus." [WB:WBPaper00031246, WB:WBPerson712] is_a: WBPhenotype:0000607 ! coelomic_system_physiology_abnormal [Term] id: WBPhenotype:0001641 name: posterior_body_wall_contraction_defective def: "Animals lack or exhibit defects in the posterior body muscle contractions of the defecation cycle." [WB:WBPaper00031426, WB:WBPerson712] synonym: "pBoc" RELATED [] is_a: WBPhenotype:0000157 ! posterior_body_wall_contraction_abnormal [Term] id: WBPhenotype:0001642 name: cell_cleavage_abnormal_emb def: "Any alteration that disrupts normal embryonic cleavage patterns (such as cleavage rate, division axes or asymmetric division)." [WB:WBPaper00001032, WB:WBPerson2021] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001643 name: excess_hypodermal_cells def: "Any abnormality that results in a greater than\nwild-type number of embryonic hypodermal cells." [WB:WBPerson2021] synonym: "Skn" BROAD three_letter_name [] is_a: WBPhenotype:0000701 ! epithelial_development_abnormal [Term] id: WBPhenotype:0001644 name: protein_metabolism_abnormal is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0001645 name: protein_degradation_abnormal is_a: WBPhenotype:0001644 ! protein_metabolism_abnormal [Term] id: WBPhenotype:0001646 name: no_pharynx def: "Embryos completely lack any structures that morphologically resemble a pharynx." [WB:WBPaper00001521, WB:WBPerson2021] is_a: WBPhenotype:0000707 ! pharyngeal_development_abnormal [Term] id: WBPhenotype:0001647 name: posterior_pharynx_abnormal is_a: WBPhenotype:0000707 ! pharyngeal_development_abnormal [Term] id: WBPhenotype:0001648 name: no_posterior_pharynx def: "Embryos fail to generate the MS blastomere- derived pharyngeal cells, which constitute the posterior portion of the pharynx." [WB:WBPaper00002330, WB:WBPerson2021] is_a: WBPhenotype:0001646 ! no_pharynx is_a: WBPhenotype:0001647 ! posterior_pharynx_abnormal [Term] id: WBPhenotype:0001649 name: Fluorouracil_resistant def: "Fluorouracil (5-FU) induces germ cell death, inhibits embryogenesis and inhibits larval growth (depending on dose) in normal animals. In addition, most germ cell nuclei are condensed. Animals resistant to the effects of 5-FU exhibit fewer cell deaths, less cell nuclei damage and/or are able to grow on 5-FU at doses that inhibit growth of normal animals." [WB:WBPaper00031571, WB:WBPerson721] synonym: "5_FU_resistant" EXACT [] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001650 name: germ_cell_death_response_to_5_FU_resistant def: "Cell death is differentially affected in response to treatment with 5-FU compared with the response in normal animals. 5-FU exposed animals do not exhibit condensed germ cell nuclei or exhibit less unhealthy nuclei than control animals." [WB:WBPaper00031571, WB:WBPerson721] is_a: WBPhenotype:0001649 ! Fluorouracil_resistant [Term] id: WBPhenotype:0001651 name: growth_arrest_response_to_5_FU_resistant def: "Animals grow well during or after exposure to 5-FU under conditions where normal animals are growth inhibited." [WB:WBPaper00031571, WB:WBPerson721] is_a: WBPhenotype:0001649 ! Fluorouracil_resistant [Term] id: WBPhenotype:0001652 name: anchor_cell_invasion_abnormal def: "Any abnormality in the process by which the gonad anchor cell makes contact with vulval cells in order to create a uterine-vulval connection. This includes the loss of the basement membranes between these cells and the crossing of the basolateral portion of the anchor cell through this gap." [WB:WBPaper00005989] is_a: WBPhenotype:0000283 ! vulva_uterus_connection_defective [Term] id: WBPhenotype:0001653 name: cadmium_response_abnormal is_a: WBPhenotype:0000591 ! metal_response_abnormal [Term] id: WBPhenotype:0001654 name: resistant_to_cadmium is_a: WBPhenotype:0001653 ! cadmium_response_abnormal [Term] id: WBPhenotype:0001655 name: cadmium_hypersensitive is_a: WBPhenotype:0001653 ! cadmium_response_abnormal [Term] id: WBPhenotype:0001656 name: distal_tip_cell_development_abnormal is_a: WBPhenotype:0000399 ! somatic_gonad_development_abnormal [Term] id: WBPhenotype:0001657 name: cell_junction_abnormal def: "Animals exhibit defects in the specialized region of connection between two cells or between a cell and the extracellular matrix." [GO:0030054, WB:WBPaper00031590, WB:WBPerson712] is_a: WBPhenotype:0001399 ! cell_membrane_morphology_abnormal [Term] id: WBPhenotype:0001658 name: intercellular_junction_abnormal def: "Animals exhibit defects in the specialized region of connection between two cells." [GO:0005911, WB:WBPaper00031590, WB:WBPerson712] synonym: "cell_cell_junction_abnormal" RELATED [] is_a: WBPhenotype:0001657 ! cell_junction_abnormal [Term] id: WBPhenotype:0001659 name: spermatheca_morphology_abnormal is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_abnormal [Term] id: WBPhenotype:0001660 name: loss_of_asymmetry_ASE def: "The two morphologically bilaterally symmetric gustatory neurons ASE left (ASEL) and ASE right (ASER) fail to undergo a left/right asymmetric diversification in cell fate." [WB:WBPaper00030973, WB:WBPerson2021] synonym: "2ASEL" NARROW [] synonym: "2ASER" NARROW [] is_a: WBPhenotype:0001512 ! loss_of_left_right_neuronal_asymmetry [Term] id: WBPhenotype:0001661 name: loss_of_asymmetry_AWC def: "The two morphologically bilaterally symmetric olfactory neurons AWC left (AWCL) and AWC right (AWCR) fail to undergo a left/right asymmetric diversification in cell fate." [WB:WBPaper00003760, WB:WBPerson2021] synonym: "2 AWC off" NARROW [] synonym: "2 AWC on" NARROW [] is_a: WBPhenotype:0001512 ! loss_of_left_right_neuronal_asymmetry [Term] id: WBPhenotype:0001662 name: spermatheca_development_abnormal is_a: WBPhenotype:0000399 ! somatic_gonad_development_abnormal [Term] id: WBPhenotype:0001663 name: organism_oxidative_stress_resistant is_a: WBPhenotype:0001620 ! organism_oxidative_stress_response_abnormal [Term] id: WBPhenotype:0001664 name: X_chromosome_nondisjunction def: "The frequency of sex chromosome segregation is perturbed, resulting in the production of exceptional gametes (e.g. ova or sperm) and populations with a sex ratio altered from the rate of 1:500 as observed for normal populations. " [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0001174 ! chromosome_disjunction_abnormal [Term] id: WBPhenotype:0001665 name: low_incidence_male_progeny def: "Lower numbers of male progeny occur in the population as a result of a decrease in the rate of X chromosome nondisjunction." [WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001666 name: organism_hypersensitive_X_ray_irradiation def: "Animals exhibit increased sensitivity to iononizing radiation with a wavelength in the 10 to 0.01 nanometer range. Increased sensitivity to X-ray irradiation is often observed as a decrease in survival upon exposure compared to normal animals given the same treatment." [WB:WBPaper00000565, WB:WBPaper00003886, WB:WBPerson712] is_a: WBPhenotype:0000276 ! organism_X_ray_response_abnormal is_a: WBPhenotype:0000711 ! organism_hypersensitive_ionizing_radiation [Term] id: WBPhenotype:0001667 name: methyl_methanesulfonate_hypersensitive def: "Animals exhibit increased sensitivity to the chemical mutagen methyl methanesulfonate (MMS) a methanesulfonate ester and alkylating agent. Increased sensitivity to MMS can be observed as a decrease in egg hatch upon acute exposure or inhibition of growth after chronic exposure compared to normal animals given the same treatment." [WB:WBPaper00000565, WB:WBPerson712] synonym: "MMS_hypersensitive" EXACT [] is_a: WBPhenotype:0000498 ! methyl_methanesulfonate_response_abnormal [Term] id: WBPhenotype:0001668 name: oocyte_accumulation def: "Oocyte accumulation occurs when oocytes are present in a non-linear arrangement in the proximal gonad without becoming endomitotic." [WB:WBPaper00006281, WB:WBPaper00030855] is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_abnormal [Term] id: WBPhenotype:0001669 name: presynaptic_vesicle_number_abnormal def: "Animals exhibit a deviation in the ratio of synaptic vesicles per synapse of a neuron, compared to that observed in normal animals." [WB:WBPaper00027305, WB:WBPerson712] synonym: "synaptic_vesicle_number_abnormal" RELATED [] is_a: WBPhenotype:0001321 ! presynaptic_region_morphology_abnormal [Term] id: WBPhenotype:0001670 name: presynaptic_vesicle_number_reduced def: "Animals exhibit an overall decrease in the quantity of synaptic vesicles at the synapse compared to what is observed in a normal animal." [WB:WBPaper00027305, WB:WBPerson712] synonym: "synaptic_vesicle_number_reduced" RELATED [] is_a: WBPhenotype:0001669 ! presynaptic_vesicle_number_abnormal [Term] id: WBPhenotype:0001671 name: vesicle_organization_abnormal is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0001672 name: commisure_growth_abnormal def: "Any deviation in the extension of the part of the axon that forms a bridge between body regions, compared to that in normal animals." [WB:WBPerson2021, WB:WBPerson712] is_a: WBPhenotype:0001224 ! axon_outgrowth_abnormal [Term] id: WBPhenotype:0001673 name: telomere_homeostasis_abnormal def: "Animals exhibit defects in the processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA, which allow the chromosome to persist from generation to generation." [GO:0032204, WB:WBPaper00031585, WB:WBPerson712] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_abnormal [Term] id: WBPhenotype:0001674 name: telomere_morphology_abnormal def: "Animals exhibit alterations in the sequence or organization of the components of the terminal region of its chromosome, i.e.telomere, which serves to stabilize the chromosome." [GO:0000781, WB:WBPaper00003886, WB:WBPerson712] is_a: WBPhenotype:0001348 ! chromosome_morphology_abnormal [Term] id: WBPhenotype:0001675 name: male_gonad_development_abnormal def: "Animals exhibit defects in the development of the gonad part of the reproductive system, from its formation to the mature structure in the male." [WB:WBPerson712] is_a: WBPhenotype:0000691 ! gonad_development_abnormal [Term] id: WBPhenotype:0001676 name: touch_receptor_cell_morphology_abnormal def: "Animals exhibit deviations in the structure or composition of any neuron within the class of sensory neurons responsible for relaying mechanical stimuli to the animal." [WB:WBPaper00000550, WB:WBPerson712] synonym: "mechanosensory_neuron_abnormal" RELATED [] synonym: "microtubule_cell_morphology_abnormal" RELATED [] is_a: WBPhenotype:0000905 ! neuron_morphology_abnormal [Term] id: WBPhenotype:0001677 name: stage_specific_cuticle_antigenicity_abnormal def: "Animals display cuticle components normally displayed by animals of a different developmental stage." [WB:WBPaper00002589, WB:WBPerson712] synonym: "Srf" NARROW [] is_a: WBPhenotype:0001687 ! surface_antigenicity_abnormal [Term] id: WBPhenotype:0001678 name: cuticle_physiology_abnormal def: "Animals produce cuticles that are missing proteins or carbohydrates observed in normal animals of the same developmental stage and raised under the same conditions." [WB:WBPaper00001576, WB:WBPerson712] is_a: WBPhenotype:0001210 ! pericellular_component_physiology_abnormal [Term] id: WBPhenotype:0001679 name: multipolar_neuron def: "Neurons have more than one process extending from the cell body." [WB:WBPaper00031901, WB:WBPerson712] is_a: WBPhenotype:0000905 ! neuron_morphology_abnormal [Term] id: WBPhenotype:0001680 name: adoption_of_fused_vulval_cell_fate def: "Vulval precursor cells forgo further cell division and fuse to the hypodermis instead of adopting their intended fate (becoming primary (1), secondary (2) or tertiary (3) vulval cells)." [WB:WBPerson2021, WB:WBPerson712] synonym: "F_fate_abnormal " RELATED [] synonym: "VPC_fused_fate_abnormal" RELATED [] is_a: WBPhenotype:0001272 ! vulval_cell_induction_abnormal [Term] id: WBPhenotype:0001681 name: spindle_orientation_abnormal def: "The alignment of the spindle relative to other cellular structures is abnormal from that observed in normal animals." [GO:0051294, WB:WBPaper00031898, WB:WBPerson712] is_a: WBPhenotype:0001344 ! organelle_organization_biogenesis_abnormal [Term] id: WBPhenotype:0001682 name: organism_UV_resistant is_a: WBPhenotype:0000143 ! organism_UV_response_abnormal [Term] id: WBPhenotype:0001683 name: spermatogenesis_defective_hermaphrodite def: "Any alteration that specifically disrupts sperm production in XX animals. By contrast, spermatogenesis in XO animals remains unaffected." [WB:WBPaper00002113, WB:WBPaper00002631] is_a: WBPhenotype:0000670 ! spermatogenesis_abnormal [Term] id: WBPhenotype:0001684 name: synaptic_vesicle_homeostasis_abnormal def: "The rates of synaptic vesicle exocytosis and endocytosis is not at the steady state as observed in normal animals." [WB:WBPaper00031872, WB:WBPerson712] is_a: WBPhenotype:0000846 ! presynaptic_region_physiology_abnormal [Term] id: WBPhenotype:0001685 name: postsynaptic_region_morphology_abnormal def: "The region opposite to the presynaptic region deviates in the structure, configuration or ratio of its components specific for receiving signals from the other side of the synapse." [WB:WBPaper00031872, WB:WBPerson712] is_a: WBPhenotype:0000616 ! synapse_morphology_abnormal [Term] id: WBPhenotype:0001686 name: postsynaptic_region_physiology_abnormal is_a: WBPhenotype:0000584 ! synaptic_transmission_abnormal [Term] id: WBPhenotype:0001687 name: surface_antigenicity_abnormal def: "Cuticles of animals or cuticular extracts exhibit an altered pattern of antibody binding compared to Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712] synonym: "Srf" EXACT [] is_a: WBPhenotype:0001688 ! surface_coat_abnormal [Term] id: WBPhenotype:0001688 name: surface_coat_abnormal def: "The electron dense, amorphous envelope that comprises the outermost layer of the cuticle is disrupted or altered in composition from that observed in normal animals of the same developmental stage. The integrity of the surface coat is often revealed by an altered antigenicity or biochemical make up." [GO:0060104] synonym: "Srf" EXACT [] is_a: WBPhenotype:0000201 ! cuticle_development_abnormal is_a: WBPhenotype:0001678 ! cuticle_physiology_abnormal [Term] id: WBPhenotype:0001689 name: surface_antigen_negative def: "Cuticles or cuticular extracts do not bind antibodies that are observed to bind the surfaces or cuticular extracts of Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712] synonym: "Srf" NARROW [] is_a: WBPhenotype:0001687 ! surface_antigenicity_abnormal [Term] id: WBPhenotype:0001690 name: constitutive_larval_display def: "Animals display surface antigens throughout all larval stages, unlike Bristol N2 worms, which display the antigens only during one larval stage. " [WB:WBPaper00002589, WB:WBPerson712] synonym: "Cld" BROAD three_letter_name [] is_a: WBPhenotype:0001677 ! stage_specific_cuticle_antigenicity_abnormal [Term] id: WBPhenotype:0001691 name: rachis_morphology_abnormal def: "Germ nuclei are misplaced in the gonad and are observed in the rachis. Sheath cells are observed protruding between these nuclei. Meiotic or mitotic specification of germ nuclei is not affected." [WB:WBPaper00031889, WB:WBPerson712] synonym: "germ_line_morphogenesis(Glm)" NARROW [] is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_abnormal [Term] id: WBPhenotype:0001692 name: pheromone_induced_larval_display_abnormal def: "Animals are not induced to display surface antigens by exposure to pheromone as observed for Bristol/N2 animals." [WB:WBPaper00002589, WB:WBPerson712] synonym: "ILD_abnormal" EXACT [] synonym: "induced_larval_display_abnormal" RELATED [] is_a: WBPhenotype:0001687 ! surface_antigenicity_abnormal [Term] id: WBPhenotype:0001693 name: posterior_alae def: "Adult males have ectopic alae that extend into the tail region." [WB:WBPerson557] synonym: "Pal" BROAD three_letter_name [] is_a: WBPhenotype:0000202 ! alae_abnormal [Term] id: WBPhenotype:0001694 name: spermatogenesis_to_oogenesis_switch_abnormal def: "Hermaphrodites continue to produce sperm past the time at which the transition to oogenesis normally occurs. Thus, germ cells that would normally become oocytes are transformed into sperm instead." [WB:WBPaper00001883, WB:WBPaper00002113, WB:WBPerson2021] is_a: WBPhenotype:0001572 ! masculinized [Term] id: WBPhenotype:0001695 name: glycosyltransferase_activity_abnormal def: "Animals exhibit deficiencies or alterations in their catalytic ability the transfer glycolsyl groups from one compound (donor) to another (acceptor) often measured by a reduction in the amount of glycosylated products compared to that observed in normal animals of the same developmental stage." [GO:0016757, WB:WBPerson712] is_a: WBPhenotype:0000733 ! catalysis_abnormal [Term] id: WBPhenotype:0001696 name: biosynthesis_abnormal def: "Animals exhibit deficiencies or alterations in the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GO:0009058, WB:WBPaper00029024, WB:WBPerson712] is_a: WBPhenotype:0000463 ! metabolic_pathway_abnormal [Term] id: WBPhenotype:0001697 name: chondroitin_biosynthesis_abnormal def: "Animals exhibit deficiencies or alterations in the chemical reactions and pathways resulting in the formation of chondroitin sulfate." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712] is_a: WBPhenotype:0001696 ! biosynthesis_abnormal [Term] id: WBPhenotype:0001698 name: heparan_sulfate_biosynthesis_abnormal def: "Animals exhibit deficiencies or alterations in the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan" [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712] is_a: WBPhenotype:0001696 ! biosynthesis_abnormal [Term] id: WBPhenotype:0001699 name: localized_movement_abnormal is_a: WBPhenotype:0001206 ! movement_abnormal [Term] id: WBPhenotype:0001700 name: swimming_abnormal synonym: "movement_in_liquid_abnormal" RELATED [] synonym: "thrashing_abnormal" RELATED [] is_a: WBPhenotype:0001206 ! movement_abnormal [Term] id: WBPhenotype:0001701 name: spastic_locomotion is_a: WBPhenotype:0004017 ! locomotor_coordination_abnormal [Term] id: WBPhenotype:0001702 name: directionality_abnormal synonym: "reversal_abnormal" RELATED [] synonym: "turning_abnormal" RELATED [] is_a: WBPhenotype:0004017 ! locomotor_coordination_abnormal [Term] id: WBPhenotype:0001703 name: body_bend_abnormal relationship: part_of WBPhenotype:0004018 ! sinusoidal_movement_abnormal [Term] id: WBPhenotype:0001704 name: multiple_alae def: "Alae are composed of more than three cuticular ridges." [WB:WBPaper00026841, WB:WBPerson557] is_a: WBPhenotype:0001412 ! alae_morphology_abnormal [Term] id: WBPhenotype:0001705 name: nucleocytoplasmic_transport_abnormal def: "The directed movement of molecules between the nucleus and the cytoplasm is impaired" [GO:0006913 , WB:WBPerson557] is_a: WBPhenotype:0001283 ! organelle_metabolism_abnormal [Term] id: WBPhenotype:0001706 name: nuclear_export_abnormal def: "The directed movement of substances out of the nucleus is impaired " [GO:0051168 , WB:WBPerson557] is_a: WBPhenotype:0001705 ! nucleocytoplasmic_transport_abnormal [Term] id: WBPhenotype:0001707 name: nuclear_import_abnormal def: "The directed movement of substances into the nucleus is impaired" [GO:0051170 , WB:WBPerson557] is_a: WBPhenotype:0001705 ! nucleocytoplasmic_transport_abnormal [Term] id: WBPhenotype:0001708 name: protein_export_from_nucleus_abnormal def: "The directed movement of a protein from the nucleus into the cytoplasm is impaired" [GO:0006611, WB:WBPerson557] is_a: WBPhenotype:0001706 ! nuclear_export_abnormal [Term] id: WBPhenotype:0004001 name: hermaphrodite_mating_abnormal def: "Characteristic hermaphrodite behavior during mating is altered." [WB:WBPerson557] is_a: WBPhenotype:0000647 ! copulation_abnormal is_a: WBPhenotype:0000887 ! hermaphrodite_behavior_abnormal [Term] id: WBPhenotype:0004002 name: attraction_signal_defective def: "Hermaphrodites defective for the production of the sensory signal to attract males" [WB:WBPaper00005109, WB:WBPerson557] is_a: WBPhenotype:0004015 ! pre_male_contact_abnormal [Term] id: WBPhenotype:0004003 name: mate_finding_abnormal def: "Impaired ability of the male to respond to the hermaphrodite produced mate-finding cue." [WB:WBPaper00005109] is_a: WBPhenotype:0004005 ! pre_hermaphrodite_contact_abnormal [Term] id: WBPhenotype:0004004 name: male_response_to_contact_defective def: "The inability of a male to respond properly to a potential mate after contact. Proper response includes apposing the ventral side of his tail to the hermaphrodite's body and swimming backward." [WB:WBPaper00000392, WB:WBPaper00002109, WB:WBPerson557] is_a: WBPhenotype:0001414 ! male_mating_defective is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_abnormal [Term] id: WBPhenotype:0004005 name: pre_hermaphrodite_contact_abnormal def: "Characteristic male mating prior to hermaphrodite contact is altered" [WB:WBPerson557] is_a: WBPhenotype:0000648 ! male_mating_abnormal [Term] id: WBPhenotype:0004006 name: post_hermaphrodite_contact_abnormal def: "characteristic of male mating after hermaphrodite contact is altered" [WB:WBPerson557] is_a: WBPhenotype:0000648 ! male_mating_abnormal [Term] id: WBPhenotype:0004007 name: periodic_spicule_prodding_defective is_a: WBPhenotype:0000279 ! spicule_insertion_defective [Term] id: WBPhenotype:0004008 name: sustained_spicule_protraction_defective is_a: WBPhenotype:0000279 ! spicule_insertion_defective [Term] id: WBPhenotype:0004009 name: approximate_vulval_location_abnormal is_a: WBPhenotype:0000649 ! vulva_location_abnormal [Term] id: WBPhenotype:0004010 name: precise_vulval_location_abnormal is_a: WBPhenotype:0000649 ! vulva_location_abnormal [Term] id: WBPhenotype:0004011 name: sperm_transfer_cessation_defective is_a: WBPhenotype:0000284 ! sperm_transfer_defective [Term] id: WBPhenotype:0004012 name: sperm_transfer_continuation_defective is_a: WBPhenotype:0000284 ! sperm_transfer_defective [Term] id: WBPhenotype:0004013 name: sperm_release_defective is_a: WBPhenotype:0000284 ! sperm_transfer_defective [Term] id: WBPhenotype:0004014 name: post_male_contact_abnormal is_a: WBPhenotype:0004001 ! hermaphrodite_mating_abnormal [Term] id: WBPhenotype:0004015 name: pre_male_contact_abnormal is_a: WBPhenotype:0004001 ! hermaphrodite_mating_abnormal [Term] id: WBPhenotype:0004016 name: dauer_nictation_behavior_abnormal is_a: WBPhenotype:0001001 ! dauer_behavior_abnormal [Term] id: WBPhenotype:0004017 name: locomotor_coordination_abnormal def: "An altered ability to maintain characteristic and effective locomotion." [WB:WBperson557] is_a: WBPhenotype:0000643 ! locomotion_abnormal [Term] id: WBPhenotype:0004018 name: sinusoidal_movement_abnormal is_a: WBPhenotype:0004017 ! locomotor_coordination_abnormal [Term] id: WBPhenotype:0004022 name: amplitude_of_movement_abnormal relationship: part_of WBPhenotype:0004018 ! sinusoidal_movement_abnormal [Term] id: WBPhenotype:0004023 name: frequency_of_body_bend_abnormal is_a: WBPhenotype:0001703 ! body_bend_abnormal [Term] id: WBPhenotype:0004024 name: wavelength_of_movement_abnormal relationship: part_of WBPhenotype:0004018 ! sinusoidal_movement_abnormal [Term] id: WBPhenotype:0004025 name: velocity_of_movement_abnormal relationship: part_of WBPhenotype:0004018 ! sinusoidal_movement_abnormal [Term] id: WBPhenotype:0004026 name: nose_touch_abnormal def: "Any alteration in the ability of an animal to respond with characteristic backward movement after a nose-on collision with an object, usually assayed with a hair or similar fiber. The nose is the anterior most tip of the animal. " [WB:WBPaper00001705, WB:WBPerson557] is_a: WBPhenotype:0000315 ! mechanosensation_abnormal [Term] id: WBPhenotype:0004027 name: plate_tap_reflex_abnormal def: "abnormal response to substrate vibration" [WB:WBPerson557] is_a: WBPhenotype:0000315 ! mechanosensation_abnormal [Term] id: WBPhenotype:0004028 name: slowing_response_on_food_abnormal is_a: WBPhenotype:0000315 ! mechanosensation_abnormal [Term] id: WBPhenotype:0004029 name: sexually_dimorphic_mechanosensation_abnormal is_a: WBPhenotype:0000315 ! mechanosensation_abnormal [Term] id: WBPhenotype:0004030 name: male_response_to_hermaphrodite_abnormal is_a: WBPhenotype:0004029 ! sexually_dimorphic_mechanosensation_abnormal [Term] id: WBPhenotype:0004031 name: mate_searching_abnormal def: "An altered ability to search for a mate as defined by failure of the \"leaving assay\"" [WB:WBPaper00024428] is_a: WBPhenotype:0004005 ! pre_hermaphrodite_contact_abnormal [Term] id: WBPhenotype:0006001 name: squashed_vulva def: "Alterations that result in the apparent partial collapse of the vulval invagination and the elongation of central vulva cells." [WB:WBPaper00003405] is_a: WBPhenotype:0000510 ! vulval_invagination_abnormal_L4 [Term] id: WBPhenotype:0008001 name: embryonic_cell_fate_specification_abnormal def: "Any abnormality in the processes that govern acquisition of particular cell fates in the embryo, from the time of zygote formation until hatching." [WB:kmva] is_a: WBPhenotype:0000216 ! cell_fate_specification_abnormal is_a: WBPhenotype:0000749 ! embryonic_development_abnormal [Term] id: WBPhenotype:0008002 name: embryonic_somatic_cell_fate_specification_abnormal def: "Any abnormality in the processes that govern acquisition of somatic cell fates in the embryo, from the time of zygote formation until hatching." [WB:kmva] is_a: WBPhenotype:0008001 ! embryonic_cell_fate_specification_abnormal [Term] id: WBPhenotype:0008003 name: odorant_imprinting_abnormal def: "Any abnormality that results in alterations to the process of odorant imprinting, a learned olfactory response whereby exposure of animals to odorants during specific developmental times or physiological states results in a lasting memory that determines the animal's behavior upon encountering the same odorant at a later time." [WB:WBPaper00026662, WB:WBPerson1843] synonym: "olfactory_imprinting_abnormal" EXACT [] is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_abnormal [Term] id: WBPhenotype:0010001 name: cell_growth_abnormal def: "The process(es) by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present, is altered." [GO:0016049, WB:rk] subset: phenotype_slim_wb is_a: WBPhenotype:0000536 ! cell_physiology_abnormal [Term] id: WBPhenotype:0010002 name: cell_organization_biogenesis_abnormal def: "The process(es) involved in the assembly and arrangement of cell structures is altered." [GO:0016043, WB:rk] subset: phenotype_slim_wb is_a: WBPhenotype:0000533 ! cell_morphology_abnormal [Term] id: WBPhenotype:0010003 name: cell_corpse_appearance_delayed def: "The appearance of cell corpses and their clearance is delayed " [WB:rk] is_a: WBPhenotype:0000185 ! apoptosis_protracted [Term] id: WBPhenotype:0010004 name: cell_corpse_degradation_abnormal def: "The normal process(es) that constitute cell corpse degradation within the engulfing cell is altered." [WB:rk] xref: WB:rk is_a: WBPhenotype:0000730 ! apoptosis_abnormal [Typedef] id: part_of name: part_of subset: phenotype_slim_wb is_transitive: true