format-version: 1.2 date: 25:03:2010 16:04 saved-by: garys auto-generated-by: OBO-Edit 1.002 subsetdef: phenotype_slim_wb "WB phenotype slim" synonymtypedef: three_letter_name "Short_name" BROAD default-namespace: C_elegans_phenotype_ontology [Term] id: WBPhenotype:0000000 name: chromosome_instability def: "Variations in the frequencies of translocations, inversions, deletions, or gene amplifications and variations in chromosome fusion events and or chromosomal loss compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000001 name: body_posture_variant def: "Animals exhibit variations in body posture compared to control animals. For example, in C. elegans characteristic sinusoidal body posture is altered." [WB:cab] subset: phenotype_slim_wb synonym: "body_posture_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000002 name: kinker def: "The animal moves or rests with uncharacteristic muscle spasms causing loss of smooth sinusoidal motion or body posture. Movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the wild type. " [WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0004017 ! locomotor_coordination_variant [Term] id: WBPhenotype:0000004 name: constitutive_egg_laying def: "Eggs are laid under conditions where egg laying is normally inhibited." [WB:cab] comment: Liquid M9. synonym: "Egl_c" BROAD three_letter_name [] is_a: WBPhenotype:0000005 ! hyperactive_egg_laying [Term] id: WBPhenotype:0000005 name: hyperactive_egg_laying def: "Eggs are laid at an earlier stage of development, eggs are laid in the presence of inhibitors of egg laying, or the inactive phase of the egg-laying cycle is significantly shorter when compared to control." [WB:cab] is_a: WBPhenotype:0000640 ! egg_laying_variant [Term] id: WBPhenotype:0000006 name: egg_laying_defective def: "Eggs are not laid, laid at a slower rate or eggs are laid at a later stage of development compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPaper00025054] synonym: "Egl_D" BROAD three_letter_name [] is_a: WBPhenotype:0000640 ! egg_laying_variant [Term] id: WBPhenotype:0000007 name: bag_of_worms def: "A worm carcass is formed with retained eggs that hatch inside." [WB:cab] is_a: WBPhenotype:0000862 ! bloated [Term] id: WBPhenotype:0000008 name: anesthetic_hypersensitive def: "Animals respond to anesthetic at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive is_a: WBPhenotype:0000627 ! anesthetic_response_variant [Term] id: WBPhenotype:0000009 name: anesthetic_resistant def: "Animals fail to respond to the concentration of anesthetic that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0000627 ! anesthetic_response_variant [Term] id: WBPhenotype:0000010 name: drug_hypersensitive def: "Animals respond to a specific drug at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0000011 name: drug_resistant def: "Animals fail to respond to the concentration of a drug that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0000012 name: dauer_constitutive def: "Formation of dauer larvae under conditions that do not favor dauer formation." [WB:kmva] synonym: "Daf_c" BROAD three_letter_name [] is_a: WBPhenotype:0000637 ! dauer_formation_variant [Term] id: WBPhenotype:0000013 name: dauer_defective def: "Failure to form dauer larvae under dauer-inducing conditions." [WB:kmva] is_a: WBPhenotype:0000637 ! dauer_formation_variant [Term] id: WBPhenotype:0000014 name: cord_commissures_variant def: "Variations in the structure, organization or path of axon tracts that grow circumferentially around the animal in a single, directed trajectory to bridge the ventral and dorsal cords, compared to control animals." [WB:WBPaper00001499, WB:WBPaper00029065, WB:WBPerson712] synonym: "cord_commissures_abnormal" NARROW [] is_a: WBPhenotype:0001226 ! commissure_variant [Term] id: WBPhenotype:0000015 name: positive_chemotaxis_defective def: "Variations in the movement towards typically attractive chemicals." [WB:cab] is_a: WBPhenotype:0000635 ! positive_chemotaxis_variant [Term] id: WBPhenotype:0000016 name: aldicarb_hypersensitive def: "Animals respond to aldicarb at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] synonym: "Hic" BROAD three_letter_name [] is_a: WBPhenotype:0000500 ! acetylcholinesterase_inhibitor_hypersensitive is_a: WBPhenotype:0000680 ! aldicarb_response_variant [Term] id: WBPhenotype:0000017 name: aldicarb_resistant def: "Animals fail to respond to the concentration of aldicarb that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] synonym: "Ric" BROAD three_letter_name [] is_a: WBPhenotype:0000680 ! aldicarb_response_variant is_a: WBPhenotype:0001289 ! acetylcholinesterase_inhibitor_resistant [Term] id: WBPhenotype:0000018 name: pharyngeal_pumping_increased def: "The contraction and relaxation movements of the pharynx occur at a greater frequency compared to that observed for control animals." [WB:WBPerson712] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_variant [Term] id: WBPhenotype:0000019 name: pharyngeal_pumping_reduced def: "Pharyngeal pumping motion occurs at a slower rate than control animals." [WB:WBPaper00001709] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_variant [Term] id: WBPhenotype:0000020 name: pharyngeal_pumping_irregular def: "Pharyngeal pumping motion occurs at intervals that vary from control animals." [WB:WBPaper00001709] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_variant [Term] id: WBPhenotype:0000021 name: squat def: "Squat animals are dumpy as homozygotes, but roll as heterozygotes." [WB:WBPaper00000906] synonym: "Sqt" BROAD three_letter_name [] is_a: WBPhenotype:0000231 ! body_size_variant [Term] id: WBPhenotype:0000022 name: long def: "Animals are longer and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31] synonym: "Lon" BROAD three_letter_name [] is_a: WBPhenotype:0001726 ! body_length_variant [Term] id: WBPhenotype:0000023 name: serotonin_hypersensitive def: "Animals respond to serotonin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000024 name: serotonin_resistant def: "Animals fail to respond to the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000025 name: blistered def: "Fluid-filled blisters appear on the cuticle." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497] synonym: "Bli" BROAD three_letter_name [] is_a: WBPhenotype:0000948 ! cuticle_morphology_variant [Term] id: WBPhenotype:0000026 name: lipid_depleted def: "Animals are unable to take up or store lipids. In C. elegans, this defect results in pale, skinny and arrested larva." [GO:0006629, WB:WBPaper00005707, WB:WBPerson712] synonym: "fat_depleted" RELATED [] synonym: "Lpd" RELATED [] is_a: WBPhenotype:0001183 ! fat_content_reduced [Term] id: WBPhenotype:0000027 name: organism_metabolism_processing_variant def: "Variations in the the chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances compared to control." [GO:0008152, WB:WBPerson2021, WB:WBPerson557] synonym: "organism_metabolism_processing_abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000028 name: RNA_processing_variant def: "Variations in the processes involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules compared to control." [GO:0006396, WB:WBPerson2021] synonym: "RNA_processing_abnormal" NARROW [] is_a: WBPhenotype:0000113 ! RNA_expression_variant [Term] id: WBPhenotype:0000029 name: systemic_RNAi_variant def: "Animals are defective for RNAi introduced by environmental means such as in the cases of RNAi triggered by soaking or feeding." [WB:WBPaper00029209, WB:WBPaper00030758, WB:WBPerson712] synonym: "Environmental RNAi defective" RELATED [] synonym: "systemic_RNAi_abnormal" NARROW [] is_a: WBPhenotype:0000743 ! RNAi_response_variant [Term] id: WBPhenotype:0000030 name: growth_variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) compared to control animals." [GO:0040007, WB:WBPerson2021] synonym: "growth_abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000031 name: slow_growth def: "Any variation that causes a reduction in growth rate compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497, WB:WBPerson557] synonym: "Gro" BROAD three_letter_name [] is_a: WBPhenotype:0000030 ! growth_variant [Term] id: WBPhenotype:0000032 name: sick def: "Animals exhibit some combination of abnormal features relating to size, movement, body integrity, pigmentation, viability, fertility etc." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712] synonym: "Sck" BROAD three_letter_name [] is_a: WBPhenotype:0000030 ! growth_variant [Term] id: WBPhenotype:0000033 name: developmental_timing_variant alt_id: WBPhenotype:0000437 def: "The timing of specific developmental events in some tissues is altered relative to the timing of events in other tissues." [pmid:6494891, WB:cab] comment: Possible XP GO:0040034 subset: phenotype_slim_wb synonym: "developmental_timing_abnormal" NARROW [] synonym: "heterochronic_defect" EXACT [] is_a: WBPhenotype:0000531 ! organism_development_variant [Term] id: WBPhenotype:0000034 name: embryonic_polarity_variant def: "Contents or structures of an embryonic cell are no longer restricted/localized to their typical positions (or poles) within the cell." [WB:WBPaper00005079, WB:WBPerson2021, WB:WBPerson712] synonym: "embryonic_polarity_abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000035 name: larval_body_morphology_variant def: "Any variation in the overall structure or appearance of the animal as it progresses from hatching to adult compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "larval_body_morphology_abnormal" NARROW [] synonym: "larval_morphology_abnormal" RELATED [] is_a: WBPhenotype:0000072 ! body_morphology_variant is_a: WBPhenotype:0000934 ! developmental_morphology_variant [Term] id: WBPhenotype:0000036 name: adult_body_morphology_variant def: "Any variation in the overall structure or appearance of the animal after it has completed progression through the larval stages compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "adult_body_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000072 ! body_morphology_variant is_a: WBPhenotype:0000934 ! developmental_morphology_variant [Term] id: WBPhenotype:0000037 name: egg_morphology_variant def: "Any variation in the overall structure or appearance of fertilized oocytes that are laid compared to those laid by control animals." [WB:WBPaper00001075, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "egg_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000934 ! developmental_morphology_variant [Term] id: WBPhenotype:0000038 name: exploded_through_vulva def: "The animal is ruptured at the vulva and displays an extrusion of internal organs at the site of rupture." [WB:WBPaper00027633, WB:WBPaper00031094, WB:WBPerson712] synonym: "gonad_eversion" RELATED [] synonym: "gonad_exploded_through_vulva" RELATED [] synonym: "Rup" BROAD three_letter_name [] is_a: WBPhenotype:0000619 ! epithelial_system_development_variant [Term] id: WBPhenotype:0000039 name: life_span_variant def: "Adult life span is either longer or shorter than typical of control animals." [GO:0008340, WB:cab, WB:WBPaper00005863, WB:WBPaper00026717, WB:WBPerson557] subset: phenotype_slim_wb synonym: "Age" BROAD three_letter_name [] synonym: "life_span_abnormal" NARROW [] synonym: "longevity_abnormal" RELATED [] is_a: WBPhenotype:0000576 ! organism_physiology_variant [Term] id: WBPhenotype:0000040 name: one_cell_arrest_early_emb def: "Embryos fail to divide and arrest as one-cell embryos." [WB:cab, WB:cgc5599] synonym: "catastrophic_one_cell_arrest" RELATED [WB:cgc5599] synonym: "Emb" BROAD [] synonym: "Ocs" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000041 name: osmotic_integrity_variant def: "Any variation in the process involved in the maintenance of an internal equilibrium of water within an organism, compared to control." [GO:0030104, WB:WBPerson2021] synonym: "osmoregulation_variant" RELATED [] synonym: "osmotic_integrity_abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000042 name: slow_embryonic_development def: "The progression through stages between fertilization to hatching are temporally retarded." [WB:WBPerson712] synonym: "Sle" BROAD three_letter_name [] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000043 name: general_pace_of_development_variant def: "Variations in the progression time of an animal from pronuclei meeting to adulthood compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "general_pace_of_development_abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism_development_variant is_a: WBPhenotype:0000576 ! organism_physiology_variant [Term] id: WBPhenotype:0000044 name: egg_size_defective_early_emb def: "Egg is smaller or larger compared to eggs of control animals." [WB:cab, WB:cgc7141] synonym: "egg_size_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000037 ! egg_morphology_variant is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000045 name: developmental_delay_postembryonic def: "The developmental progression of an animal after the embryonic stage, over time, from its formation to its mature structure is delayed compared to control. " [WB:cab, WB:WBPaper00025054] is_a: WBPhenotype:0000049 ! postembryonic_development_variant [Term] id: WBPhenotype:0000046 name: pace_of_P_lineage_defective_early_emb def: "More than five minutes between AB and P1 divisions." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] synonym: "pace_of_P_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell_division_variant is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_variant [Term] id: WBPhenotype:0000047 name: gastrulation_variant def: "Variations in the process by which the germ layers become positioned in an embryo compared to control animals. Gastrulation involves the proper ingression of small groups of cells at various times into the blastocoel space." [WB:WBPaper00027251, WB:WBPerson2021] synonym: "gastrulation_abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000048 name: hatching_variant def: "Variations in the ability of an animal to emerge from the protective egg shell compared to control animals." [GO:0035188, WB:WBPerson2021] synonym: "hatching_abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000049 name: postembryonic_development_variant def: "Any variation in the progression of an animal over time, from hatching to adulthood, compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "postembryonic_development_abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism_development_variant [Term] id: WBPhenotype:0000050 name: embryonic_lethal def: "Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die." [WB:cab, WB:WBPaper00000179, WB:WBPaper00004403, WB:WBPaper00004540, WB:WBPaper00004651, WB:WBPaper00004769, WB:WBPaper00005654, WB:WBPaper00024497, WB:WBPaper00024925, WB:WBPaper00025054] subset: phenotype_slim_wb synonym: "Emb" BROAD three_letter_name [] synonym: "embryonic_death" RELATED [] synonym: "inviable_zygote" RELATED [] is_a: WBPhenotype:0000062 ! lethal is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000051 name: embryonic_terminal_arrest_variable_emb def: "The developmental program does not continue past embryogenesis; stage of arrest is not consistent from animal to animal." [GO:0009790, WB:WBPaper00004811, WB:WBPaper00024944, WB:WBPerson712] synonym: "Emb" BROAD [] synonym: "Etv" RELATED [] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000052 name: maternal_effect_lethal_emb def: "Lethality caused by the perturbation of maternal gene products that are contributed to oogenesis and are required during embryogenesis." [WB:WBPaper00001109, WB:WBPerson2021] synonym: "Emb" BROAD [] synonym: "Mel" BROAD three_letter_name [] is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0000053 name: paralyzed_arrested_elongation_two_fold def: "Movement and elongation ceases at the two-fold stage. The myofilament lattice in body wall muscle cells is variant. However, development in embryos continues. Embryos hatch as inviable larvae." [WB:cab, WB:cgc1894] synonym: "active_elongation_arrest" RELATED [] synonym: "Pat" BROAD three_letter_name [] synonym: "two_fold_arrest" RELATED [] is_a: WBPhenotype:0000050 ! embryonic_lethal is_a: WBPhenotype:0000494 ! two_fold_arrest [Term] id: WBPhenotype:0000054 name: larval_lethal def: "The animal dies at any time between hatching and onset to adulthood." [GO:0002119, WB:WBPerson712] subset: phenotype_slim_wb synonym: "larval_death" RELATED [] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000055 name: early_larval_arrest def: "Larvae arrest during early larval development. In C. elegans, this occurs during the L1 or L2 stages of larval development." [WB:cab] is_a: WBPhenotype:0000059 ! larval_arrest [Term] id: WBPhenotype:0000056 name: late_larval_arrest def: "Larvae arrest during late larval development. In C. elegans, larval arrest occurs during the L3 or L4 stages of larval development." [WB:cab] is_a: WBPhenotype:0000059 ! larval_arrest [Term] id: WBPhenotype:0000057 name: early_larval_lethal def: "Animals die during early larval development. In C.elegans, this occurs during the L1- L2 larval stages of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000054 ! larval_lethal [Term] id: WBPhenotype:0000058 name: late_larval_lethal def: "Animals die during late larval development. In C. elegans, this occurs during the L3- L4 larval stages of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000054 ! larval_lethal [Term] id: WBPhenotype:0000059 name: larval_arrest def: "The developmental program of the animals halts at any larval stage and thus fails to reach adulthood. In C.elegans, this occurs anytime during L1-L4 stage." [WB:WBPaper00002958, WB:WBPerson2021] synonym: "Lva" BROAD three_letter_name [] is_a: WBPhenotype:0000750 ! larval_development_variant is_a: WBPhenotype:0001016 ! larval_growth_variant [Term] id: WBPhenotype:0000060 name: adult_lethal def: "Premature lethality during the adult stage. When applied to large-scale RNAi screens in C. elegans, this phenotype is present in at least 10% of analyzed worms, or at least 30% in the case of rrf-3 perturbed background." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPaper00006395] subset: phenotype_slim_wb synonym: "Adl" BROAD three_letter_name [WB:WBPaper00004402, WB:WBPaper00005654] synonym: "Let" BROAD [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000061 name: extended_life_span def: "The duration of viability in the adult phase of the life-cycle surpasses that of control animals." [GO:0008340, WB:WBPerson712] synonym: "Age" BROAD three_letter_name [] synonym: "longevity_increased" RELATED [] is_a: WBPhenotype:0000039 ! life_span_variant [Term] id: WBPhenotype:0000062 name: lethal def: "Animals die prematurely at any stage of the life cycle." [WB:WBPaper00001109, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "Let" BROAD three_letter_name [] is_a: WBPhenotype:0000531 ! organism_development_variant [Term] id: WBPhenotype:0000063 name: terminal_arrest_variable def: "Variations that cause developmental progression to cease at different stages of the lifecycle." [WB:WBPerson2021, WB:WBPerson557] synonym: "Var" BROAD three_letter_name [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000064 name: sexually_dimorphic_lethality def: "Animals die prematurely at any stage of the life cycle in a sex dependent manner." [WB:WBPerson2021, WB:WBPerson557] synonym: "Let" RELATED [] is_a: WBPhenotype:0000062 ! lethal [Term] id: WBPhenotype:0000065 name: X0_lethal def: "XO-bearing individuals die preferentially over other animals in the population. In C.elegans, X0 animals die preferentially over XX animals" [WB:WBPerson363, WB:WBPerson712] subset: phenotype_slim_wb synonym: "Let" BROAD [] synonym: "male specific lethality" RELATED [] is_a: WBPhenotype:0000064 ! sexually_dimorphic_lethality [Term] id: WBPhenotype:0000066 name: XX_lethal def: "XX-bearing individuals die preferentially over other animals in the population. In C.elegans, XX animals die preferentially over X0 animals." [WB:WBPerson363, WB:WBPerson712] subset: phenotype_slim_wb synonym: "hermaphrodite specific lethality" RELATED [] is_a: WBPhenotype:0000064 ! sexually_dimorphic_lethality [Term] id: WBPhenotype:0000067 name: organism_stress_response_variant def: "Animals exhibit variations in response to stress stimuli compared to control animals." [GO:0006950, WB:WBPerson712] synonym: "organism_stress_response_abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0000068 name: oxidative_stress_response_variant def: "Any variation in the state or activity of a cell (in terms of secretion, enzyme production, gene expression, etc.) in response to high levels of reactive oxygen species, compared to control." [GO:0006979, WB:WBPerson2021, WB:WBPerson557] synonym: "oxidative_stress_response_abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell_stress_response_variant [Term] id: WBPhenotype:0000069 name: progeny_variant def: "Any variation in the progression of the progeny of an animal at any time from its fertilization to adulthood compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "progeny_abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism_development_variant [Term] id: WBPhenotype:0000070 name: male_tail_morphology_variant def: "Animals exhibit variations in the structure or organization of the somatic reproductive components of the posterior segment of the male from that observed in control males. In C. elegans, this region of the male includes the terminal canals of the reproductive tract, the digestive tract, and spicule channels along with the male specific sensilla (ray, post-cloacal, hook and spicule) and extends to the tip of the acellular fan." [WB:WBPaper00027278, WB:WBPerson712] synonym: "Mab" BROAD three_letter_name [] synonym: "male_tail_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000073 ! tail_morphology_variant is_a: WBPhenotype:0001024 ! male_morphology_variant [Term] id: WBPhenotype:0000071 name: head_morphology_variant def: "Animals exhibit variations in the form, structure or composition of any portion of their \nanterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring) compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "head_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000582 ! organism_segment_morphology_variant [Term] id: WBPhenotype:0000072 name: body_morphology_variant def: "Animals exhibit variations in the form, structure or composition of any portion of their anatomy between the head and the tail compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "body_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000582 ! organism_segment_morphology_variant [Term] id: WBPhenotype:0000073 name: tail_morphology_variant def: "Animals exhibit variations in the form, structure or composition of any portion of the most posterior region of the body compared to control. The anterior bound of the tail is not well defined though it might range from the position of the post-deirids to the opening of the anus (Wormatlas)" [WB:WBPerson2021, WB:WBPerson557] synonym: "tail_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000582 ! organism_segment_morphology_variant [Term] id: WBPhenotype:0000074 name: genetic_pathway_variant def: "Any variation in the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "genetic_pathway_abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism_physiology_variant [Term] id: WBPhenotype:0000075 name: cuticle_attachment_variant def: "Any variation in the attachment of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) to the outer body of an animal compared to control (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "cuticle_attachment_abnormal" NARROW [] is_a: WBPhenotype:0000201 ! cuticle_development_variant [Term] id: WBPhenotype:0000076 name: epithelial_attachment_variant def: "Variations in the adhesion of the layer of cells that cover the external surface of an organism\nwhich serves to protect the animal from external environment compared to control. " [WB:WBPerson2021, WB:WBPerson557] synonym: "epithelial_attachment_abnormal" NARROW [] synonym: "hypodermal_attachment_abnormal" RELATED [] is_a: WBPhenotype:0000608 ! epithelial_system_physiology_variant [Term] id: WBPhenotype:0000077 name: cuticle_shedding_defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement." [GO:0018996] synonym: "cuticle_shedding_abnormal" NARROW [] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000078 name: seam_cells_stacked def: "The hypodermal cells, which lie along the lateral bodywall to form longitudinal stripes of epithelial cells underlying the alae, are misplaced such that they are stacked along the dorsal-ventral axis rather than forming a continuous row of adjacent cells ." [WB:WBPaper00003081] is_a: WBPhenotype:0000703 ! epithelial_morphology_variant [Term] id: WBPhenotype:0000079 name: branched_adult_alae def: "The small linear ridges running along the lateral lines of the cuticle of adults are branched as opposed to having an unbiforcated arrangement, lengthwise along the body (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001412 ! alae_morphology_variant [Term] id: WBPhenotype:0000080 name: no_anterior_pharynx def: "Animals lack the anterior portion of the pharynx." [WB:WBPerson2021, WB:WBPerson557] synonym: "Aph" BROAD three_letter_name [] is_a: WBPhenotype:0000115 ! anterior_pharynx_variant is_a: WBPhenotype:0001646 ! no_pharynx [Term] id: WBPhenotype:0000081 name: L1_arrest def: "The developmental program of the animals does not continue past the first larval stage (L1)." [WB:WBPaper00003179, WB:WBPerson2021] is_a: WBPhenotype:0000055 ! early_larval_arrest is_a: WBPhenotype:0000751 ! L1_larval_development_variant [Term] id: WBPhenotype:0000082 name: L2_arrest def: "The developmental program of the animals does not continue past the second larval stage (L2)." [WB:WBPaper00003179, WB:WBPerson2021] is_a: WBPhenotype:0000055 ! early_larval_arrest is_a: WBPhenotype:0000752 ! L2_larval_development_variant is_a: WBPhenotype:0001019 ! mid_larval_arrest [Term] id: WBPhenotype:0000083 name: L3_arrest def: "The developmental program of the animals does not continue past the third larval stage (L3)." [WB:WBPaper00004813, WB:WBPerson2021] is_a: WBPhenotype:0000056 ! late_larval_arrest is_a: WBPhenotype:0000753 ! L3_larval_development_variant is_a: WBPhenotype:0001019 ! mid_larval_arrest [Term] id: WBPhenotype:0000084 name: L4_arrest def: "The developmental program of the animals does not continue past the fourth larval stage (L4)." [WB:WBPaper00003179, WB:WBPerson2021] is_a: WBPhenotype:0000056 ! late_larval_arrest is_a: WBPhenotype:0000754 ! L4_larval_development_variant [Term] id: WBPhenotype:0000085 name: swollen_intestine def: "The intestinal lumen is expanded and can often be shown to be filled with bacteria." [WB:WBPaper00026641, WB:WBPerson712] is_a: WBPhenotype:0000710 ! intestinal_morphology_variant [Term] id: WBPhenotype:0000086 name: shrunken_intestine def: "Intestine is shrunken and may appear constricted." [WB:WBPaper00005941] is_a: WBPhenotype:0000710 ! intestinal_morphology_variant [Term] id: WBPhenotype:0000087 name: body_wall_cell_development_variant def: "Any variation in the progression of a body wall muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "body_wall_cell_development_abnormal" NARROW [] synonym: "body_wall_muscle_cell_development_abnormal" RELATED [] is_a: WBPhenotype:0000815 ! muscle_cell_development_variant [Term] id: WBPhenotype:0000088 name: body_muscle_displaced def: "The arrangement of the principal muscle cell type whose contractile activity generates body motion in the nematode differs from that observed in control animals. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the bodywall (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_wall_muscle_displaced" RELATED [] is_a: WBPhenotype:0000861 ! body_wall_muscle_development_variant [Term] id: WBPhenotype:0000089 name: alpha_amanitin_resistant def: "Animals fail to respond to the concentration of alpha amanitin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000090 name: epidermis_cuticle_detached def: "Animals are deficient in the adhesion of the cuticle to the epidermal surface of the animal." [WB:WBPerson2021, WB:WBPerson557] synonym: "hypodermis_detached_from_cuticle" RELATED [] is_a: WBPhenotype:0000075 ! cuticle_attachment_variant is_a: WBPhenotype:0000076 ! epithelial_attachment_variant [Term] id: WBPhenotype:0000091 name: epidermis_muscle_detached def: "The cell(s) whose principal function is to provide contractile forces, is separated from the adjacent epidermis." [WB:WBPerson2021, WB:WBPerson557] synonym: "hypodermis_detached_from_muscle" RELATED [] is_a: WBPhenotype:0000076 ! epithelial_attachment_variant is_a: WBPhenotype:0000474 ! muscle_attachment_variant [Term] id: WBPhenotype:0000092 name: intestinal_cell_proliferation_variant def: "Any variation in the processes that govern the expansion of intestinal cell populations compared to control." [WB:WBPerson2021] synonym: "intestinal_cell_proliferation_abnormal" NARROW [] is_a: WBPhenotype:0000705 ! intestinal_cell_development_variant [Term] id: WBPhenotype:0000093 name: lineage_variant def: "The descendants of a particular precursor cell exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "Lin" BROAD three_letter_name [] synonym: "lineage_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000094 name: anus_development_variant def: "Any variation in the progression of the caudal opening of the rectum in the tail over time compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "anus_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_variant [Term] id: WBPhenotype:0000095 name: M_lineage_variant def: "The descendants of the M precursor cell exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "M_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000096 name: cloacal_development_variant def: "Variations in the progression of the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) over time compared to control (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "cloacal_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_variant [Term] id: WBPhenotype:0000097 name: AB_lineage_variant def: "The descendants of the AB blastomere exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPaper00001584, WB:WBPerson2021] synonym: "AB_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_variant [Term] id: WBPhenotype:0000098 name: pharyngeal_intestinal_valve_development_variant def: "Any variation in the progression of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine over time compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal_intestinal_valve_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_variant [Term] id: WBPhenotype:0000099 name: P_lineages_variant def: "The descendants of any of the P precursor cells exhibit variations in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "P_lineages_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000100 name: cell_UV_response_variant def: "Cells exhibit variations in their response to ultraviolet radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "cell_UV_response_abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell_stress_response_variant [Term] id: WBPhenotype:0000101 name: UV_induced_apoptosis_increased def: "Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, UV irradiation, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000100 ! cell_UV_response_variant is_a: WBPhenotype:0000183 ! apoptosis_increased [Term] id: WBPhenotype:0000102 name: presynaptic_vesicle_cluster_variant def: "Animals display variations in the organization, accumulation or distribution of transmitter-containing membrane-bound organelles (synaptic vesicles) compared to that observed in control animals." [WB:WBPaper00027305] synonym: "presynaptic_vesicle_cluster_abnormal" NARROW [] synonym: "synaptic_vesicle_cluster_abnormal" RELATED [] relationship: part_of WBPhenotype:0001321 ! presynaptic_region_morphology_variant [Term] id: WBPhenotype:0000103 name: gut_granule_development_variant def: "Any variation in the progression of the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes over time compared to control. In C. elegans these contents might include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas).\n" [WB:WBPerson2021, WB:WBPerson557] synonym: "gut_granule_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000705 ! intestinal_cell_development_variant [Term] id: WBPhenotype:0000104 name: cell_polarity_variant def: "Contents or structures of a cell are no longer restricted/localized to their typical positions within the cell." [WB:WBPaper00031356, WB:WBPerson2021, WB:WBPerson712] subset: phenotype_slim_wb synonym: "cell_polarity_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000105 name: oocyte_meiotic_maturation_variant def: "Variations in the progression of a developing oocyte, from diakinesis to metaphase (meiosis I), in response to a signal compared to control animals. Meiotic maturation is accompanied by nuclear envelope breakdown (germinal vesicle breakdown), cytoskeletal rearrangement and meiotic spindle assembly." [GO:0001556, WB:WBPaper00026997, WB:WBPerson2021] synonym: "Oma" BROAD three_letter_name [] synonym: "oocyte_meiotic_maturation_abnormal" NARROW [] is_a: WBPhenotype:0000313 ! meiotic_progression_during_oogenesis_variant [Term] id: WBPhenotype:0000106 name: inhibition_of_oocyte_maturation_variant def: "Variations in the processes that negatively regulate the meiotic progression of oocytes (exit from diakinesis) in the absence of a signal compared to control animals." [WB:WBPaper00003371, WB:WBPaper00026997, WB:WBPerson2021] synonym: "inhibition_of_oocyte_maturation_abnormal" NARROW [] is_a: WBPhenotype:0000105 ! oocyte_meiotic_maturation_variant [Term] id: WBPhenotype:0000107 name: inhibition_of_ovulation_variant def: "Any variation that alters the control mechanisms that inhibit oocyte maturation and release of a mature oocyte into the spermatheca (for subsequent fertilization), compared to control." [GO:0060280, WB:WBPerson2021, WB:WBPerson557] synonym: "inhibition_of_ovulation_abnormal" NARROW [] is_a: WBPhenotype:0000666 ! ovulation_variant [Term] id: WBPhenotype:0000108 name: severe_dumpy is_obsolete: true [Term] id: WBPhenotype:0000109 name: moderate_dumpy is_obsolete: true [Term] id: WBPhenotype:0000110 name: slightly_dumpy is_obsolete: true [Term] id: WBPhenotype:0000111 name: pattern_of_gene_expression_variant def: "Any variation in the cellular or subcellular distribution of a gene product compared to that observed in control animals." [WB:WBPerson2021] synonym: "pattern_of_gene_expression_abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene_expression_variant [Term] id: WBPhenotype:0000112 name: protein_expression_variant def: "Variations in the biogenesis and stability of protein molecules compared to control." [WB:WBPerson2021] synonym: "protein_expression_abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene_expression_variant [Term] id: WBPhenotype:0000113 name: RNA_expression_variant def: "Variations in the biogenesis and stability of any class of RNA molecules (rRNAs, miRNAs, tRNAs etc) compared to control." [WB:WBPerson2021] synonym: "RNA_expression_abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene_expression_variant [Term] id: WBPhenotype:0000114 name: mRNA_expression_variant def: "Variations in the biogenesis and stability of messenger RNA molecules compared to control." [GO:0050684, WB:WBPerson2021] synonym: "mRNA_expression_abnormal" NARROW [] is_a: WBPhenotype:0000113 ! RNA_expression_variant [Term] id: WBPhenotype:0000115 name: anterior_pharynx_variant def: "Any variation in the progression of the anterior portion of the pharynx over time compared to control. In C. elegans the anterior region includes the corpus (procorpus and metacorpus - first bulb)." [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior_pharynx_abnormal" NARROW [] is_a: WBPhenotype:0000707 ! pharyngeal_development_variant [Term] id: WBPhenotype:0000116 name: mid_larval_lethal def: "Animals die in between the early and late larval stages. In C. elegans, this occurs during the L2- L3 larval stages of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD three_letter_name [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000054 ! larval_lethal [Term] id: WBPhenotype:0000117 name: L1_lethal def: "Animals die at the L1 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000057 ! early_larval_lethal [Term] id: WBPhenotype:0000118 name: L2_lethal def: "L2_lethal: Animals die at the L2 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD three_letter_name [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000057 ! early_larval_lethal is_a: WBPhenotype:0000116 ! mid_larval_lethal [Term] id: WBPhenotype:0000119 name: protein_expression_increased def: "Any change that results in higher than normal levels of protein expression compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001400 ! level_of_protein_expression_variant [Term] id: WBPhenotype:0000120 name: protein_expression_reduced def: "Any change that results in lower than normal levels of protein expression compared to control animals." [WB:kmva] is_a: WBPhenotype:0001400 ! level_of_protein_expression_variant [Term] id: WBPhenotype:0000121 name: translation_variant def: "Variations in the chemical reactions and pathways resulting in the formation of a protein, compared to control." [GO:0006412, WB:WBPerson2021] synonym: "protein_synthesis_abnormal" RELATED [] synonym: "translation_abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein_expression_variant [Term] id: WBPhenotype:0000122 name: post_translational_processing_variant def: "Any variation in the posttranslational modification of a protein (which may include cleavage of peptide bonds) leading to the attainment of the full functional capacity of the protein compared to control. " [GO:0016485, WB:WBPerson2021, WB:WBPerson557] synonym: "post_translational_processing_abnormal" NARROW [] synonym: "protein_processing_variant" RELATED [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0000123 name: enzyme_expression_level_reduced def: "Variations that cause a decrease in the expression level of a biological catalyst, compared to control animals. " [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0000124 name: enzyme_activity_reduced def: "Any variation that results in a decrease in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000727 ! enzyme_activity_variant [Term] id: WBPhenotype:0000125 name: enzyme_activity_increased def: "Any variation that results in an increase in the catalytic activity of an enzyme compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000727 ! enzyme_activity_variant [Term] id: WBPhenotype:0000126 name: general_pace_of_development_defective_early_emb def: "Variations in the time from pronuclei meeting to furrow initiation during the first cell division compared to control animals." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] synonym: "general_pace_of_development_abnormal" NARROW [] is_a: WBPhenotype:0000043 ! general_pace_of_development_variant is_a: WBPhenotype:0001186 ! embryo_delayed_at_pronuclear_contact_early_emb [Term] id: WBPhenotype:0000127 name: dauer_recovery_variant def: "Characteristic exit from the dauer stage is altered compared to control animals." [WB:cab] synonym: "dauer_recovery_abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer_arrest_variant [Term] id: WBPhenotype:0000128 name: temperature_induced_dauer_formation_increased def: "Animals are more likely to form dauers at temperatures that do not induce dauer entry in control animals." [WB:cgc424] synonym: "Hid" BROAD three_letter_name [] is_a: WBPhenotype:0000639 ! temperature_induced_dauer_formation_variant [Term] id: WBPhenotype:0000129 name: temperature_induced_dauer_formation_defective def: "Animals do not enter dauer at a temperature that induces dauer formation in control animals. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000013 ! dauer_defective is_a: WBPhenotype:0000639 ! temperature_induced_dauer_formation_variant [Term] id: WBPhenotype:0000130 name: pheromone_induced_dauer_formation_enhanced def: "Animals enter the dauer stage when exposed to lower concentrations or shorter exposure times of chemicals that induce dauer formation compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000132 ! pheromone_induced_dauer_formation_variant [Term] id: WBPhenotype:0000131 name: pheromone_induced_dauer_formation_defective def: "Animals do not enter dauer when exposed to chemicals that induce dauer formation in control animals. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000013 ! dauer_defective is_a: WBPhenotype:0000132 ! pheromone_induced_dauer_formation_variant [Term] id: WBPhenotype:0000132 name: pheromone_induced_dauer_formation_variant def: "Animals exhibit variations in the entry into the dauer stage when exposed to concentrations of chemicals that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "pheromone_induced_dauer_formation_abnormal" NARROW [] is_a: WBPhenotype:0001539 ! dauer_induction_variant [Term] id: WBPhenotype:0000133 name: expression_lipogenic_enzyme_reduced def: "The levels of an enzyme involved in the manufacture of lipids are decreased compared to control animals" [WB:WBPerson2021] is_a: WBPhenotype:0000123 ! enzyme_expression_level_reduced [Term] id: WBPhenotype:0000134 name: gene_expression_level_reduced def: "Animals exhibit a decrease in the intensity of expression of a gene product compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene_expression_variant [Term] id: WBPhenotype:0000135 name: gene_expression_level_high def: "Animals exhibit an increase in the intensity of expression of a gene product compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene_expression_variant [Term] id: WBPhenotype:0000136 name: mRNA_levels_increased def: "Animals exhibit elevated levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021] is_a: WBPhenotype:0000114 ! mRNA_expression_variant [Term] id: WBPhenotype:0000137 name: mRNA_levels_reduced def: "Animals exhibit decreased levels of messenger RNA compared to control." [WB:WBPaper00033456, WB:WBPerson2021] is_a: WBPhenotype:0000114 ! mRNA_expression_variant [Term] id: WBPhenotype:0000138 name: lipid_composition_variant def: "The constituent parts or ratio of elements that make up lipids are altered when compared to that of control animals." [WB:WBPerson712] synonym: "fat_composition_abnormal" RELATED [] synonym: "fatty_acid_composition_abnormal" RELATED [] synonym: "lipid_composition_abnormal" NARROW [] is_a: WBPhenotype:0000725 ! lipid_metabolism_variant [Term] id: WBPhenotype:0000139 name: stress_induced_lethality_variant def: "Animals exhibit variations in survival when exposed to stress stimuli that induce lethality in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "stress_induced_lethality_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000140 name: stress_induced_arrest_variant def: "Animals exhibit variations in cessation of development when exposed to stress stimuli that induce developmental arrest in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "stress_induced_arrest_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000141 name: stress_induced_lethality_increased def: "Animal populations exhibit a further decrease in survival when exposed to stress stimuli compared to the lethality rate observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000139 ! stress_induced_lethality_variant [Term] id: WBPhenotype:0000142 name: cell_stress_response_variant def: "Variations in the activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress, compared to control. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GO:0033554, WB:WBPerson2021] synonym: "cell_stress_response_abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000143 name: organism_UV_response_variant def: "Animals exhibit variations in their response to ultraviolet radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "organism_UV_response_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000144 name: pathogen_induced_cell_death_increased def: "Animals exhibit an increase in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000142 ! cell_stress_response_variant is_a: WBPhenotype:0001269 ! pathogen_induced_cell_death_variant [Term] id: WBPhenotype:0000145 name: fertility_variant def: "Animals exhibit variations in the time of onset or duration of the fertile period, or production of new individuals that contain some portion of their genetic material inherited from that organism compared to control." [GO:0000003, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "fertility_abnormal" NARROW [] is_a: WBPhenotype:0000613 ! reproductive_system_physiology_variant [Term] id: WBPhenotype:0000146 name: organism_temperature_response_variant def: "Animals do not respond to changes in temperature or thermal stress in the same manner as control animals. In C.elegans this is often measured by changes in the expression of stress proteins or changes in life span." [WB:WBPerson712] synonym: "organism_temperature_response_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000147 name: organism_starvation_response_variant def: "Any variation in the state or activity of an organism as a result of deprivation of nourishment, compared to control." [GO:0042594, WB:WBPerson2021] synonym: "organism_starvation_response_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000148 name: starvation_induced_dauer_formation_variant def: "Animals exhibit variations in the entry into the dauer stage when exposed to nutrient poor conditions that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "starvation_induced_dauer_formation_abnormal" NARROW [] is_a: WBPhenotype:0000147 ! organism_starvation_response_variant is_a: WBPhenotype:0001539 ! dauer_induction_variant [Term] id: WBPhenotype:0000149 name: starvation_induced_dauer_formation_increased def: "Animals are more likely to form dauers under nutrient conditions that do not induce dauer entry in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000148 ! starvation_induced_dauer_formation_variant [Term] id: WBPhenotype:0000150 name: starvation_induced_dauer_formation_defective def: "Animals do not enter dauer under nutrient-poor conditions that induce dauer formation in control animals. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000013 ! dauer_defective is_a: WBPhenotype:0000148 ! starvation_induced_dauer_formation_variant [Term] id: WBPhenotype:0000151 name: anterior_pharynx_extra_cells def: "Embryos generate an excess number of anterior derived pharyngeal cells. In C. elegans, embryos generate an excess number of AB blastomere-derived pharyngeal cells. This hyperinduction of anterior pharyngeal tissue is associated with defects in fate specification of the ABp blastomere." [WB:WBPaper00001930, WB:WBPerson2021] synonym: "Apx " BROAD three_letter_name [] is_a: WBPhenotype:0000115 ! anterior_pharynx_variant [Term] id: WBPhenotype:0000152 name: no_cleavage_furrow_first_division_early_emb def: "One-cell embryos do not form the shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [GO:0032154, WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001129 ! cleavage_furrow_defective_early_emb [Term] id: WBPhenotype:0000153 name: body_wall_contraction_variant def: "Initiation, strength, extent or cessation of body wall muscle activity that results in the shortening of the muscle, is aberrant compared to control animals." [WB:WBPaper00032190, WB:WBPerson712] synonym: "body_wall_contraction_abnormal" NARROW [] synonym: "body_wall_muscle_contraction_abnormal" RELATED [] relationship: part_of WBPhenotype:0000596 ! body_behavior_variant [Term] id: WBPhenotype:0000154 name: reduced_brood_size def: "The characteristic number of offspring produced is lower compared to that of control animals." [WB:WBPerson557] is_a: WBPhenotype:0000673 ! brood_size_variant [Term] id: WBPhenotype:0000155 name: cell_polarity_reversed def: "Contents or structures of the cell are oriented on the opposite side of the cell compared to control animals; In C. elegans, this can result in the fate pattern of descendants being flipped." [WB:WBPaper00031356, WB:WBPerson2021, WB:WBPerson712] is_a: WBPhenotype:0000104 ! cell_polarity_variant [Term] id: WBPhenotype:0000156 name: body_wall_contraction_interval_variant def: "Any variation in the time interval between successive contractions of the body wall muscles during the defecation motor program compared to cantrol." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_wall_contraction_interval_abnormal" NARROW [] synonym: "body_wall_muscle_contraction_interval_abnormal" RELATED [] is_a: WBPhenotype:0000210 ! defecation_contraction_variant [Term] id: WBPhenotype:0000157 name: posterior_body_wall_contraction_defecation_cycle_variant def: "Animals exhibit variations in the sustained posterior body muscle contractions that precede the remaining contractions of the defecation cycle compared to control animals." [WB:WBPaper00031426, WB:WBPerson712] synonym: "pBoc" BROAD three_letter_name [] synonym: "posterior_body_contraction_abnormal" RELATED [] synonym: "posterior_body_wall_contraction_abnormal" NARROW [] synonym: "posterior_body_wall_contraction_defective" RELATED [] is_a: WBPhenotype:0000210 ! defecation_contraction_variant [Term] id: WBPhenotype:0000159 name: dauer_arrest_variant def: "Animals exhibit variations in the entry/exit into a state of arrested tissue development during the dauer larval stage in response to harsh environmental conditions, compared to control. In C. elegans, the dauer larva enters a state of arrest in which no developmental changes occur, until the animal finds more suitable growing conditions, or until it spontaneously shifts back into a normal developmental schedule. (WormAtlas)" [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_arrest_abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism_physiology_variant [Term] id: WBPhenotype:0000160 name: cleavage_furrow_not_discrete_early_emb def: "Embryos do not form a defined shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [GO:0032154, WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001129 ! cleavage_furrow_defective_early_emb [Term] id: WBPhenotype:0000161 name: nuclear_rotation_variant def: "Any variation in the rotation of centrosomes and associated pronuclei in one-cell embryo, occurring as a transition between pronuclear migration and pronuclear fusion compared to control." [GO:0035047, WB:WBPerson2021, WB:WBPerson557] synonym: "nuclear_rotation_abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000162 name: pale_larva def: "Larva show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557] synonym: "translucent" RELATED [] is_a: WBPhenotype:0000890 ! larval_pigmentation_variant is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000163 name: clear_larva def: "Larva appear unusually transparent when compared to control." [WB:WBPerson557] synonym: "Clr" BROAD three_letter_name [] synonym: "transparent" RELATED [] is_a: WBPhenotype:0000890 ! larval_pigmentation_variant is_a: WBPhenotype:0001010 ! clear [Term] id: WBPhenotype:0000164 name: thin def: "Animals exhibit a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson712] synonym: "slim" RELATED [] is_a: WBPhenotype:0001727 ! body_width_variant [Term] id: WBPhenotype:0000165 name: cell_fusion_variant def: "Variations in the ability of two or more individual cells to form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes. Cell fusion is dependent on the merging of lipid bilayer membranes as well as cytoplasmic mixing." [GO:0000768, GO:0045026, WB:WBPaper00005122, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell_fusion_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000166 name: seam_cell_fusion_variant def: "Variations in the ability of seam cells to fuse to form a continuous syncytium along the bodywall late larval development, (separate from the hyp 7 syncytium), compared to control (WormAtlas). Hypodermal seam cells lie along the lateral bodywall to form longitudinal stripes of epithelial cells underlying the alae, and are required for alae formation." [WB:WBPerson2021, WB:WBPerson557] synonym: "seam_cell_fusion_abnormal" NARROW [] is_a: WBPhenotype:0000165 ! cell_fusion_variant [Term] id: WBPhenotype:0000167 name: precocious_seam_cell_fusion def: "Seam cells fuse to form a continuous syncytium along the bodywall at an earlier stage of development compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000166 ! seam_cell_fusion_variant is_a: WBPhenotype:0001433 ! precocious_cell_fusion [Term] id: WBPhenotype:0000168 name: alae_secretion_variant def: "Variations in the regulated release of proteins needed for alae formation by epidermal seam cells compared to control. Alae are small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (WormAtlas)." [WB:WBPaper00004833, WB:WBPaper00025242, WB:WBPerson2021] synonym: "alae_formation_variant" RELATED [] synonym: "alae_secretion_abnormal" NARROW [] is_a: WBPhenotype:0000258 ! cell_secretion_variant [Term] id: WBPhenotype:0000169 name: early_exit_cell_cycle def: "Cells leave the M phase (mitosis and cytokinesis) at an earlier time than sister or other control cells." [GO:0010458, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000740 ! cell_cycle_variant [Term] id: WBPhenotype:0000170 name: precocious_alae def: "Formation of alae occurs earlier in development compared to control animals; In C. elegans, adult lateral alae are typically generated during the late L4 stage." [pmid:3428573, WB:cab] is_a: WBPhenotype:0000168 ! alae_secretion_variant [Term] id: WBPhenotype:0000171 name: cell_proliferation_variant def: "Any aberrancy in the processes that govern expansion of cell populations compared to control animals." [GO:0008283, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell_proliferation_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000172 name: cell_proliferation_increased def: "The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are increased." [WB:WBPerson2021] is_a: WBPhenotype:0000171 ! cell_proliferation_variant [Term] id: WBPhenotype:0000173 name: cell_proliferation_reduced def: "The processes governing the expansion of cell populations are altered compared to control animals, such that cell populations are decreased." [WB:WBPerson2021] is_a: WBPhenotype:0000171 ! cell_proliferation_variant [Term] id: WBPhenotype:0000174 name: basal_lamina_development_variant def: "Any variation in the progression of the layer of connective tissue over the surface of tissues that serves to separate it from neighboring tissues, from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "basal_lamina_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000619 ! epithelial_system_development_variant [Term] id: WBPhenotype:0000175 name: hypercontracted def: "Excessive and often uncoordinated body wall muscle contraction leading to shortening of the body." [WB:WBPerson363] is_a: WBPhenotype:0000001 ! body_posture_variant [Term] id: WBPhenotype:0000176 name: satiety_behavior_variant def: "Any variation in the specific actions or reactions of an animal after completion of feeding, typically after a fast, compared to that observed in control animals. In C. elegans worms become behaviorally quiescent and cease feeding and moving when sated." [WB:WBPerson2021, WB:WBPerson557] synonym: "satiety_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000659 ! feeding_behavior_variant [Term] id: WBPhenotype:0000177 name: acetylcholinesterase_reduced def: "Any variation that results in a decrease of acetylcholine esterase levels, compared to control." [WB:WBPaper00024452, WB:WBPerson2021] is_a: WBPhenotype:0000124 ! enzyme_activity_reduced [Term] id: WBPhenotype:0000178 name: cell_degeneration def: "Cells are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [WB:WBPerson712] is_a: WBPhenotype:0000729 ! cell_death_variant [Term] id: WBPhenotype:0000179 name: neuron_degeneration def: "Cells specialized for receiving, conducting and transmitting impulses in the nervous system are observed to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles." [WB:WBPerson712] is_a: WBPhenotype:0000178 ! cell_degeneration [Term] id: WBPhenotype:0000180 name: axon_morphology_variant def: "Animals display variations in the structure, organization of components, or spatial pattern of the projection that conducts signal away from the cell body, compared to that observed in control animals." [GO:0030424, WB:WBPaper00005236, WB:WBPerson712] synonym: "axon_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0001398 ! neurite_morphology_variant [Term] id: WBPhenotype:0000181 name: axon_trajectory_variant def: "Animals display variations in the directed path taken by the axon compared to the path the nerve fiber follows in the nervous system in control animals." [WB:WBPaper00001105, WB:WBPerson712] synonym: "axon_trajectory_abnormal" NARROW [] is_a: WBPhenotype:0000180 ! axon_morphology_variant [Term] id: WBPhenotype:0000182 name: apoptosis_reduced def: "Any perturbation that causes a decrease in the frequency of cell death by apoptosis compared to control animals." [GO:0043065, WB:WBPerson2021] is_a: WBPhenotype:0000730 ! apoptosis_variant [Term] id: WBPhenotype:0000183 name: apoptosis_increased def: "Any perturbation that causes an elevation in the frequency of cell death by apoptosis compared to control animals." [GO:0043066, WB:WBPerson2021] is_a: WBPhenotype:0000730 ! apoptosis_variant [Term] id: WBPhenotype:0000184 name: apoptosis_fails_to_occur def: "Cells do not undergo the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes." [WB:WBPerson712] is_a: WBPhenotype:0000182 ! apoptosis_reduced [Term] id: WBPhenotype:0000185 name: apoptosis_protracted def: "Animals exhibit a decreased pace of the programmed cell death pathway, compared to that observed for control cells." [WB:WBPerson712] is_a: WBPhenotype:0000730 ! apoptosis_variant [Term] id: WBPhenotype:0000186 name: oogenesis_variant alt_id: WBPhenotype:0000896 def: "Any aberrancy in the processes that influence the generation and maturation of oocytes compared to control animals." [GO:0048477, WB:WBPerson2021] synonym: "oocyte_development_abnormal" RELATED [] synonym: "oocyte_germ_cell_differentiation_abnormal" EXACT [] synonym: "oogenesis_abnormal" NARROW [] is_a: WBPhenotype:0000894 ! germ_cell_differentiation_variant [Term] id: WBPhenotype:0000187 name: egg_round def: "The overall structure or appearance of fertilized oocytes that are laid has every part of their surface equidistant from the center." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000037 ! egg_morphology_variant [Term] id: WBPhenotype:0000188 name: gonad_arm_morphology_variant def: "Any variation in the 'arm-like' form, structure or composition of the specialized tissue of the reproductive tract that produces gametes compared to control. In C. elegans the reproductive tract in the hermaphrodite has two equivalent gonad 'arms', while the male has a one-armed gonad." [WB:WBPerson2021, WB:WBPerson557] synonym: "gonad_arm_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_variant [Term] id: WBPhenotype:0000189 name: hypodermis_disorganized def: "Hypodermal cells fail to be organized in the same manner as observed in control animals. In C. elegans, hypodermal cells typically organize into distinct dorsal, lateral and ventral rows and cover the entire body." [WB:WBPaper00027006, WB:WBPerson2021] is_a: WBPhenotype:0000703 ! epithelial_morphology_variant [Term] id: WBPhenotype:0000190 name: no_dauer_recovery def: "Animals fail to exit from the facultative diapause of the dauer larval stage of nematode development. " [GO:0043054, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000127 ! dauer_recovery_variant [Term] id: WBPhenotype:0000191 name: organism_crowding_response_variant def: "Animals exhibit variations in their response to a situation when there is too high a density of nematodes to be supported by the available amount of food and space compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism_crowding_response_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000192 name: constitutive_enzyme_activity def: "Any variation that results in the misregulation of enzymatic activity such that catalysis occurs at a constant rate regardless of physiological demand or the concentration of a substrate. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000125 ! enzyme_activity_increased [Term] id: WBPhenotype:0000193 name: dominant_negative_enzyme def: "Any variation within an enzyme that causes it to act antagonistically towards the wild-type enzymatic product. These mutations usually result in an altered molecular function (often inactive) and are characterized by a dominant or semi-dominant phenotype." [WB:WBPerson2021] is_a: WBPhenotype:0000727 ! enzyme_activity_variant [Term] id: WBPhenotype:0000194 name: first_polar_body_position_variant def: "Variations in the placement of the polar body formed in the first division of meiosis of a primary oocyte, compared to control. A polar body is the by-product of meiosis (destined to degenerate) in female or hermaphrodite animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "first_polar_body_position_abnormal" NARROW [] is_a: WBPhenotype:0000775 ! meiosis_variant [Term] id: WBPhenotype:0000195 name: distal_tip_cell_migration_variant def: " Variations in the migration pattern of distal tip cells compared to control animals. In C. elegans, DTCs located on the anterior and posterior ends of the gonad primordium typically migrate in a symmetrical U-shaped pattern." [GO:0040039, WB:WBPaper00003598, WB:WBPerson2021] synonym: "distal_tip_cell_migration_abnormal" NARROW [] synonym: "DTC_migration_abnormal" RELATED [] is_a: WBPhenotype:0000594 ! cell_migration_variant [Term] id: WBPhenotype:0000196 name: distal_tip_cell_morphology_variant def: "The morphological appearance of distal tip cells is varied compared to control animals." [WB:cab] synonym: "distal_tip_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000197 name: cell_induction_variant def: "Variations in a cell's ability to influence the fate of another cell (often of different developmental potential or ancestry via short range signaling)." [GO:0031128, WB:WBPerson2021] synonym: "cell_induction_abnormal" NARROW [] is_a: WBPhenotype:0000216 ! cell_fate_specification_variant [Term] id: WBPhenotype:0000199 name: male_tail_sensory_ray_development_variant def: "Any variation in the progression of the finger-like sensory sensilla that project from the tail and embed in the male fan from its formation to the mature structure when compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_tail_sensory_ray_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0001008 ! male_nervous_system_development_variant [Term] id: WBPhenotype:0000200 name: pericellular_component_development_variant def: "Variations in the progression of structures/tissues surrounding a cell over time from its initial formation to its mature form compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "pericellular_component_development_abnormal" NARROW [] is_a: WBPhenotype:0000518 ! development_variant [Term] id: WBPhenotype:0000201 name: cuticle_development_variant def: "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "cuticle_development_abnormal" NARROW [] is_a: WBPhenotype:0000200 ! pericellular_component_development_variant [Term] id: WBPhenotype:0000202 name: alae_variant def: "Any variation in the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "alae_abnormal" NARROW [] is_a: WBPhenotype:0000201 ! cuticle_development_variant [Term] id: WBPhenotype:0000203 name: odorant_adaptation_variant def: "Animals exhibit variations in the characteristic desensitization to a volatile organic chemo-attractive signal in a time-concentration dependent and reversible manner compared to control animals." [WB:WBPerson2021] synonym: "odorant_adaptation_abnormal" NARROW [] is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_variant [Term] id: WBPhenotype:0000204 name: anterior_body_contraction_defecation_cycle_variant def: "Variations in the anterior body muscle contraction (aBoc) step of the defecation cycle compared to control animals. Under normal conditions, anterior body wall muscles contract and pressurize the intestinal contents during the aBoc step." [WB:WBPerson2021] synonym: "aBoc" BROAD three_letter_name [] synonym: "anterior_body_contraction_abnormal" RELATED [] synonym: "anterior_body_contraction_defective" RELATED [] is_a: WBPhenotype:0001476 ! anterior_body_contraction_variant [Term] id: WBPhenotype:0000205 name: expulsion_variant def: "Any variation in the expulsion of gut contents compared to control. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion." [WB:WBPerson2021, WB:WBPerson557] synonym: "Exp" RELATED [] synonym: "expulsion_abnormal" NARROW [] is_a: WBPhenotype:0000210 ! defecation_contraction_variant [Term] id: WBPhenotype:0000206 name: autosomal_nondisjunction_meiosis def: "A non-sex chromosome fails to segregate away from its homologous chromosome, resulting in gametes with no or extra copies of the non-sex homolog." [GO:0045143, WB:WBPerson712] is_a: WBPhenotype:0001174 ! chromosome_disjunction_defective [Term] id: WBPhenotype:0000207 name: defecation_cycle_variant def: "Any variation in the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control . " [WB:WBPerson2021, WB:WBPerson557] synonym: "defecation_cycle_abnormal" NARROW [] is_a: WBPhenotype:0000650 ! defecation_variant [Term] id: WBPhenotype:0000208 name: long_defecation_cycle def: "The mean time between the onset of the defecation motor program is greater than that observed for control animals." [WB:WBPaper00002315, WB:WBPaper00031896, WB:WBPerson712] synonym: "Dec-l " RELATED [] is_a: WBPhenotype:0000207 ! defecation_cycle_variant [Term] id: WBPhenotype:0000209 name: short_defecation_cycle alt_id: WBPhenotype:0000158 def: "The mean time between the onset of the defecation motor program is shorter than that observed for control animals." [WB:WBPaper00002315, WB:WBPaper00031896, WB:WBPerson712] synonym: "Dec-s" RELATED [] synonym: "fast_Dec" RELATED [] synonym: "posterior_body_wall_shortened_interval" EXACT [] is_a: WBPhenotype:0000207 ! defecation_cycle_variant [Term] id: WBPhenotype:0000210 name: defecation_contraction_variant def: "Any variation in the stereotyped muscle contractions that result in defecation compared to control . In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp)." [WB:WBPerson2021, WB:WBPerson557] synonym: "defecation_contraction_abnormal" NARROW [] is_a: WBPhenotype:0000650 ! defecation_variant [Term] id: WBPhenotype:0000211 name: defecation_contraction_asynchronous def: "The rhythmic contractions of the muscles coordinating the elimination of gut contents are no longer synchronized compared to control. " [WB:WBPerson2021, WB:WBPerson557] synonym: "defecation_contraction_mistimed" RELATED [] is_a: WBPhenotype:0000210 ! defecation_contraction_variant [Term] id: WBPhenotype:0000212 name: body_constriction def: "Animals contain body regions that are more narrow or drawn together than adjacent body regions." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000072 ! body_morphology_variant [Term] id: WBPhenotype:0000213 name: zygotic_development_variant def: "Variations in the progression of a zygote from formation (gamete fusion) to just prior to the first cell division compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "zygotic_development_abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000214 name: alpha_amanitin_hypersensitive def: "Animals respond to alpha amanitin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000215 name: no_germ_line def: "Animals lack all germline progenitor cells, thereby resulting in the complete absence of a germline." [WB:WBPaper00001477, WB:WBPerson2021] synonym: "no_germline" EXACT [] is_a: WBPhenotype:0000812 ! germ_cell_development_variant [Term] id: WBPhenotype:0000216 name: cell_fate_specification_variant def: "Any variation in the processes that govern acquisition of particular cell fates compared to control animals." [WB:kmva] subset: phenotype_slim_wb synonym: "cell_fate_specification_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000217 name: prolonged_pharyngeal_contraction def: "The time in which a muscle contraction event that controls feeding is increased compared to control. Contractions of the pharynx are necessary for bacterial uptake from the surrounding environment." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000980 ! pharyngeal_contraction_variant [Term] id: WBPhenotype:0000218 name: vulval_cell_induction_increased def: "An excess number of vulval precursor cells receive an inductive signal leading to an increased number of VPCs adopting vulval fates compared to control animals." [WB:WBPerson2021] synonym: "Hin" BROAD three_letter_name [] synonym: "overinduced" NARROW [] is_a: WBPhenotype:0001272 ! vulval_cell_induction_variant [Term] id: WBPhenotype:0000219 name: vulval_cell_induction_reduced def: "Vulval precursor cells receive a decrease in inductive signal leading to fewer VPCs adopting vulval fates compared to control animals." [WB:WBPerson2021] synonym: "underinduced" NARROW [] is_a: WBPhenotype:0001272 ! vulval_cell_induction_variant [Term] id: WBPhenotype:0000220 name: vulva_cell_fate_specification_variant def: "Any aberrancy in the processes that govern acquisition of vulval cell fates compared to control animals." [WB:WBPerson2021] synonym: "vulva_cell_fate_specification_abnormal" NARROW [] is_a: WBPhenotype:0000216 ! cell_fate_specification_variant is_a: WBPhenotype:0000699 ! vulva_development_variant [Term] id: WBPhenotype:0000221 name: neurotransmitter_metabolism_variant def: "Animals exhibit variations in any chemical reaction or pathway involving neurotransmitters compared to control animals. Neurotransmitters are any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GO:0042133, WB:WBPerson557, WB:WBPerson712] synonym: "neurotransmitter_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0000222 name: serotonin_metabolism_variant def: "Animals exhibit variations in any chemical reaction or pathway involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter, compared to control." [GO:0042428, WB:WBPerson557, WB:WBPerson712] synonym: "serotonin_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000221 ! neurotransmitter_metabolism_variant [Term] id: WBPhenotype:0000223 name: acetylcholine_metabolism_variant def: "Animals exhibit variations in any chemical reaction or pathway involving acetylcholine, acetylcholine is the acetic acid ester of the organic base choline, compared to control." [GO:0008291, WB:WBPerson557, WB:WBPerson712] synonym: "acetylcholine_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000221 ! neurotransmitter_metabolism_variant [Term] id: WBPhenotype:0000224 name: serotonin_deficient def: "Animals do not contain or are unable to maintain a perceivable level of serotonin capable of initiating or maintaining serotonin-dependent cell activity." [WB:WBPerson712] is_a: WBPhenotype:0000222 ! serotonin_metabolism_variant [Term] id: WBPhenotype:0000225 name: serotonin_synthesis_defective def: "Animals are unable to carry out the chemical reactions and pathways resulting in the formation of serotonin." [GO:0042427, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000222 ! serotonin_metabolism_variant [Term] id: WBPhenotype:0000226 name: serotonin_catabolism_defective def: "Animals are unable to carry out any chemical reaction or pathway resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter." [GO:0042429, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000222 ! serotonin_metabolism_variant [Term] id: WBPhenotype:0000227 name: male_turning_defective def: "The inability of a male to properly turn during mating behavior. In C. elegans, males typically turn via a sharp ventral arch of the tail, as he approaches either the hermaphrodite head or tail." [GO:0034607, WB:WBPaper00000392, WB:WBPaper00002109] synonym: "male_turning_abnormal" NARROW [] is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_variant [Term] id: WBPhenotype:0000228 name: spontaneous_mutation_rate_increased def: "Animals accumulate a greater number of genetic lesions than control animals in the absence of an externally controlled mutagen. In C. elegans, this is often measured by observing the number of reversion events of a known mutant gene function over a couple generations." [WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000229 name: small alt_id: WBPhenotype:0000271 def: "Animals are shorter and thinner than control animals at the same developmental stage." [WB:cab, WB:cgc31] synonym: "body_size_reduced" EXACT [] synonym: "Sma" RELATED [] is_a: WBPhenotype:0001726 ! body_length_variant is_a: WBPhenotype:0001727 ! body_width_variant [Term] id: WBPhenotype:0000230 name: tail_withered def: "The girth of the region posterior to the vulva is reduced compared to that anterior to the vulva (the Wit phenotype). In C. elegans this phenotype is associated with anteriorward misplacement of the CAN neurons." [WB:WBPaper00002795, WB:WBPerson2021, WB:WBPerson557] synonym: "Wit" RELATED [] is_a: WBPhenotype:0000073 ! tail_morphology_variant [Term] id: WBPhenotype:0000231 name: body_size_variant def: "Animals exhibit variations in the physical dimensions of its body compared to control animals of the same developmental stage." [WB:WBPerson712] comment: PATO:0000117 synonym: "body_size_abnormal" NARROW [] is_a: WBPhenotype:0000072 ! body_morphology_variant [Term] id: WBPhenotype:0000232 name: CAN_cell_migration_variant def: "Variation in the migration pattern of CAN neurons. In C. elegans, CAN neurons move posteriorly from their birthplace in the head to positions near the middle of the embryo." [WB:WBPaper00002795, WB:WBPerson2021] synonym: "CAN_cell_migration_abnormal" NARROW [] is_a: WBPhenotype:0001520 ! posterior_neuron_migration_variant [Term] id: WBPhenotype:0000233 name: dopamine_metabolism_variant def: "Animals exhibit variations in any chemical reaction or pathway involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline, compared to control." [GO:0042417, WB:WBPerson557, WB:WBPerson712] synonym: "dopamine_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000221 ! neurotransmitter_metabolism_variant is_a: WBPhenotype:0001518 ! biogenic_amine_physiology_variant [Term] id: WBPhenotype:0000234 name: dopamine_deficient def: "Animals do not contain or are unable to maintain a perceivable level of dopamine capable of initiating or maintaining dopamine-dependent cell activity." [WB:WBPerson712] is_a: WBPhenotype:0000233 ! dopamine_metabolism_variant [Term] id: WBPhenotype:0000235 name: dopamine_synthesis_defective def: "Animals are unable to carry out the chemical reactions and pathways resulting in the formation of dopamine." [GO:0042416, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000233 ! dopamine_metabolism_variant [Term] id: WBPhenotype:0000236 name: dopamine_catabolism_defective def: "Animals are unable to carry outany chemical reaction or pathway resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GO:0042420, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000233 ! dopamine_metabolism_variant [Term] id: WBPhenotype:0000237 name: foraging_hyperactive def: "Animals extend intensity of roaming and or dwelling activity compared to control animals. In C. elegans, hyperactivity may include an increase in nose-lifts per minute." [WB:WBPaper00031455, WB:WBPaper00031570, WB:WBPerson712] is_a: WBPhenotype:0000662 ! foraging_behavior_variant [Term] id: WBPhenotype:0000238 name: foraging_reduced def: "Animals decrease intensity or rate of roaming and or dwelling activity compared to control animals." [WB:WBPaper00031455, WB:WBPerson712] is_a: WBPhenotype:0000662 ! foraging_behavior_variant [Term] id: WBPhenotype:0000239 name: vulval_cell_lineage_variant def: "The descendants of a vulval precursor cell exhibit altered developmental programs compared to their counterparts in control animals. In C. elegans, the VPCs are P3.p-P8.p " [WB:WBPaper00005610, WB:WBPerson2021] synonym: "VPC_lineage_abnormal" RELATED [] synonym: "vulval_cell_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000099 ! P_lineages_variant [Term] id: WBPhenotype:0000240 name: blast_cell_proliferation_reduced def: "The processes governing the expansion of blast cell populations vary, such that cell populations are decreased compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000173 ! cell_proliferation_reduced [Term] id: WBPhenotype:0000241 name: accumulated_cell_corpses def: "Animals exhibit an increase in the quantity of cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712] is_a: WBPhenotype:0000590 ! cell_corpse_number_variant [Term] id: WBPhenotype:0000242 name: body_elongation_defective def: "The epidermal cells of the embryo fail to elongate. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm." [WB:WBPerson2021] is_a: WBPhenotype:0001478 ! body_elongation_variant [Term] id: WBPhenotype:0000243 name: engulfment_failure_by_killer def: "Removal of cell corpses through a dedicated engulfment pathway is defective." [WB:WBPerson712] is_a: WBPhenotype:0000885 ! engulfment_variant [Term] id: WBPhenotype:0000244 name: apoptotic_arrest def: "Cells fail to complete the form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes." [WB:WBPerson712] synonym: "apoptosis_block" RELATED [] is_a: WBPhenotype:0000730 ! apoptosis_variant [Term] id: WBPhenotype:0000245 name: SM_migration_variant def: "Variations in the movement of sex myoblasts compared to control animals. In C. elegans, the larval SM migrate anteriorly to the precise center of the developing hermaphrodite gonad." [WB:WBPaper00003627, WB:WBPerson2021] synonym: "SM_migration_abnormal" NARROW [] is_a: WBPhenotype:0001230 ! anterior_cell_migration_defective [Term] id: WBPhenotype:0000246 name: defecation_cycle_variable_length def: "Animals exhibit variation in the time of onset of the defecation motor program significantly greater than that observed for control animals." [WB:WBPaper00031896, WB:WBPerson712] is_a: WBPhenotype:0000207 ! defecation_cycle_variant [Term] id: WBPhenotype:0000247 name: sodium_chemotaxis_defective def: "Failure to execute the characteristic response to sodium as defined by control animals. In C. elegans, sodium is typically an attractant" [WB:cab, WB:cgc387] synonym: "Na_chemotaxis_defective" RELATED [] synonym: "sodium acetate chemotaxis defective" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001440 ! cation_positive_chemotaxis_defective [Term] id: WBPhenotype:0000248 name: sensory_neuroanatomy_variant synonym: "sensory_neuroanatomy_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000249 name: osmotic_avoidance_defective def: "Failure to execute the characteristic avoidance response to solutions of high osmotic strength as defined by control animals." [WB:cab, WB:WBPerson2021] is_a: WBPhenotype:0000663 ! osmotic_avoidance_variant [Term] id: WBPhenotype:0000250 name: octopamine_metabolism_variant def: "Animals exhibit variations in any chemical reaction or pathway involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol, compared to control." [GO:0046333, WB:WBPerson557, WB:WBPerson712] synonym: "octopamine_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000221 ! neurotransmitter_metabolism_variant is_a: WBPhenotype:0001518 ! biogenic_amine_physiology_variant [Term] id: WBPhenotype:0000251 name: octopamine_deficient def: "Animals do not contain or are unable to maintain a perceivable level of octopamine capable of initiating or maintaining dopamine-dependent cell activity." [WB:WBPerson712] is_a: WBPhenotype:0000250 ! octopamine_metabolism_variant [Term] id: WBPhenotype:0000252 name: caffeine_resistant def: "Animals fail to respond to the concentration of caffeine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000253 name: movement_erratic def: "Animals exhibit a lack of consistency, regularity, or uniformity while traveling from one location to another. " [WB:WBPerson2021, WB:WBPerson557] synonym: "movement_irregular" RELATED [] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000254 name: chloride_chemotaxis_defective def: "Failure to execute the characteristic response to chloride. In C. elegans, chloride is typically an attractant" [WB:cab, WB:cgc387] synonym: "Cl_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001439 ! anion_positive_chemotaxis_defective is_a: WBPhenotype:0001458 ! chloride_chemotaxis_variant [Term] id: WBPhenotype:0000255 name: amphid_phasmid_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid and phasmid sensilla from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000938] comment: WBbt:0005394\nWBbt:0006753 synonym: "amphid_phasmid_morphology_abnormal" NARROW [] synonym: "dye_filling_defect" RELATED [] synonym: "Dyf" BROAD three_letter_name [] is_a: WBPhenotype:0001527 ! amphid_phasmid_sensillum_morphology_variant [Term] id: WBPhenotype:0000256 name: amphid_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the amphid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000938] comment: WBbt:0005394 synonym: "amphid_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000255 ! amphid_phasmid_morphology_variant [Term] id: WBPhenotype:0000257 name: phasmid_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the neuronal cells of the phasmid sensillum, from that observed in control animals. In C. elegans, these neurons are commonly assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000938] comment: WBbt:0006753 synonym: "phasmid_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000255 ! amphid_phasmid_morphology_variant [Term] id: WBPhenotype:0000258 name: cell_secretion_variant alt_id: WBPhenotype:0000723 def: "Variations in the regulated release of substances by a cell compared to control. " [GO:0032940, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell_secretion_abnormal" NARROW [] synonym: "cellular_secretion_abnormal" EXACT [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000259 name: sheath_cell_secretion_variant def: "Variations in the regulated release of substances by nonneuronal cells that enclose or ensheath the tips of the sensory dendrites compared to control." [WB:WBPaper00000822, WB:WBPerson2021] synonym: "sheath_cell_secretion_abnormal" NARROW [] is_a: WBPhenotype:0000258 ! cell_secretion_variant [Term] id: WBPhenotype:0000260 name: sheath_cell_secretion_failure def: "The regulated release of materials by sheath cells is disrupted. " [WB:WBPaper00028924, WB:WBPerson2021] is_a: WBPhenotype:0000259 ! sheath_cell_secretion_variant [Term] id: WBPhenotype:0000261 name: amphid_sheath_secretion_failure def: "Amphid sheath cells lack the ability to secrete vesicles and their contents within the amphid pocket." [WB:WBPaper00028924, WB:WBPerson2021] is_a: WBPhenotype:0000260 ! sheath_cell_secretion_failure [Term] id: WBPhenotype:0000262 name: axoneme_morphology_variant def: "Animals exhibit variations in the structure or composition of the microtubule-based fibrillar bundle (axoneme) that makes up the core of the middle part of the cilium (in a pattern of nine doublet microtubules attached to the membrane and a variable number of smaller singlet microtubules occupying the center). In C. elegans, the axoneme microtubules are arranged in a pattern of nine doublets attached to the membrane with seven smaller singlet microtubules occupying the center." [WB:WBPaper00000932, WB:WBPerson712] synonym: "axoneme_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000615 ! cilia_morphology_variant [Term] id: WBPhenotype:0000263 name: axoneme_short def: "The microbule-based fibrillar bundle in the core of the cilium is reduced in length compared to axonemes of similar cells in control animals." [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000262 ! axoneme_morphology_variant [Term] id: WBPhenotype:0000264 name: cAMP_chemotaxis_defective def: "Failure to execute the characteristic response to cAMP as defined by control animals. In C. elegans, cAMP is typically an attractant" [WB:cab, WB:cgc387, WB:WBPaper00001481, WB:WBPaper00002033] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001463 ! cAMP_chemotaxis_variant [Term] id: WBPhenotype:0000265 name: odorant_positive_chemotaxis_variant def: "Movement towards typically attractive volatile organic chemicals is altered as defined by control animals. In C. elegans, these odorants are typically sensed by the AWA and AWC neurons" [WB:cab, WB:cgc1786, WB:WBPerson2021] synonym: "odorant_positive_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0000635 ! positive_chemotaxis_variant is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_variant [Term] id: WBPhenotype:0000266 name: cell_cleavage_variant def: "Variations that disrupt stereotypical cleavage patterns (such as cleavage rate, division axes or asymmetric division) compared to control. " [WB:WBPerson2021, WB:WBPerson557] synonym: "cell_cleavage_abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0000267 name: cell_cleavage_delayed def: "Any variation that causes a delay in the stereotypical cleavage event compared to control. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000266 ! cell_cleavage_variant [Term] id: WBPhenotype:0000268 name: P_cell_cleavage_delayed def: "Any variation that causes a delay in the stereotypical cleavage pattern of the P cell compared to control. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000267 ! cell_cleavage_delayed [Term] id: WBPhenotype:0000269 name: unclassified def: "Animals display a phenotype that has not yet been assigned to a current classification." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000270 name: pleiotropic_defects_severe_early_emb def: " Seemingly unrelated variations that concurrently occur during early embryonic development compared to control animals. In C. elegans, this can include multiple pronuclei, aberrant cytoplasmic texture, decrease in overall pace of development and osmotic sensitivity." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001007 ! other_abnormality_early_emb [Term] id: WBPhenotype:0000272 name: egg_laying_irregular def: "The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate does not conform to the pattern observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000640 ! egg_laying_variant [Term] id: WBPhenotype:0000273 name: thrashing_reduced def: "The number of body thrashes within an aqueous environment in a given period of time are reduced compared with control worms." [WB:cab, WB:cgc7388] is_a: WBPhenotype:0001700 ! swimming_variant [Term] id: WBPhenotype:0000274 name: dead_eggs_laid def: "Animals lay eggs that are inviable." [WB:cab] is_a: WBPhenotype:0000640 ! egg_laying_variant is_a: WBPhenotype:0000806 ! hermaphrodite_fertility_variant [Term] id: WBPhenotype:0000275 name: organism_UV_hypersensitive def: "Organisms respond to UV at a lower dose or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000143 ! organism_UV_response_variant [Term] id: WBPhenotype:0000276 name: organism_X_ray_response_variant def: "Animals exhibit variations in their response to X-ray radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "organism_X_ray_response_abnormal" NARROW [] is_a: WBPhenotype:0000686 ! organism_ionizing_radiation_response_variant [Term] id: WBPhenotype:0000277 name: rhythm_slow def: "The timing of a biological cycle that recurs with regularity is delayed compared to control." [GO:0048511, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000278 name: body_region_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular body region." [WB:WBPerson557] synonym: "body_region_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000521 ! pigmentation_variant [Term] id: WBPhenotype:0000279 name: spicule_insertion_defective def: "Males exhibit defects in the insertion of the male copulatory spicules into the mating partner. In C. elegan spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [GO:0034609, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001414 ! male_mating_defective is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_variant [Term] id: WBPhenotype:0000280 name: breaks_in_alae def: "The small linear ridges running along the lateral lines of the cuticle, lengthwise along the body, contain gaps as opposed to a continuous arrangement (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001412 ! alae_morphology_variant [Term] id: WBPhenotype:0000281 name: male_sex_muscle_development_variant def: "Variations in the progression of the muscles of the adult male reproductive system over time form their initial formation to their mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_sex_muscle_development_abnormal" NARROW [] is_a: WBPhenotype:0000669 ! sex_muscle_development_variant [Term] id: WBPhenotype:0000282 name: hermaphrodite_sex_muscle_development_variant def: "Variations in the progression of the muscles of the adult hermaphrodite reproductive system over time form their initial formation to their mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite_sex_muscle_development_abnormal" NARROW [] is_a: WBPhenotype:0000669 ! sex_muscle_development_variant [Term] id: WBPhenotype:0000283 name: vulva_uterus_connection_defective def: "Animals exhibit defects in the continuity of lumen between the vulva and uterus compared to control animals." [WB:WBPaper00003386, WB:WBPaper00006298, WB:WBPaper00027236, WB:WBPaper00027316, WB:WBPerson712] synonym: "AC block" NARROW [] relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_variant [Term] id: WBPhenotype:0000284 name: sperm_transfer_defective def: "Any defect in the process whereby a male inseminates his partner by introducing sperm into the genital tract." [GO:0007320, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001414 ! male_mating_defective is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_variant [Term] id: WBPhenotype:0000285 name: ray_tips_swollen def: "The extreme ends of any of the finger-like sensory sensilla that project from the tail and embed in the male fan appear bloated or distended." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000505 ! male_ray_morphology_variant [Term] id: WBPhenotype:0000286 name: embryo_disorganized def: "Embryos fail to be organized in the same manner as observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000288 name: distal_germline_variant def: "Variations in the progression of the lineages that gives rise to all germ cells, lying in the region adjacent to the proximal gonad (on the side furthest from the founder cells of the somatic gonad), over time compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "distal_germ_line_abnormal" RELATED [] synonym: "distal_germline_abnormal" NARROW [] is_a: WBPhenotype:0000812 ! germ_cell_development_variant [Term] id: WBPhenotype:0000289 name: uterus_morphology_variant def: "Any variation in the form, structure or composition of the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca compared to control (Wormatlas).\n" [WB:WBPerson2021, WB:WBPerson557] synonym: "uterus_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0001335 ! hermaphrodite_reproductive_system_morphology_variant [Term] id: WBPhenotype:0000290 name: sperm_absent def: "Animals lack fully specialized male gametes that are competent for fertilization." [WB:WBPerson2021] is_a: WBPhenotype:0000395 ! no_differentiated_gametes [Term] id: WBPhenotype:0000291 name: no_oocytes def: "Hermaphrodites lack fully specialized female gametes that are competent for fertilization." [WB:WBPerson2021] is_a: WBPhenotype:0000395 ! no_differentiated_gametes [Term] id: WBPhenotype:0000292 name: organ_system_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a organ system." [WB:WBPerson557] synonym: "organ_system_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000521 ! pigmentation_variant [Term] id: WBPhenotype:0000293 name: alimentary_system_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the alimentary system." [WB:WBPerson557] synonym: "alimentary_system_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000292 ! organ_system_pigmentation_variant [Term] id: WBPhenotype:0000294 name: intestine_dark def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that decrease the transparency/translucency of the intestine." [WB:WBPerson557] synonym: "Din" BROAD three_letter_name [] relationship: part_of WBPhenotype:0000293 ! alimentary_system_pigmentation_variant [Term] id: WBPhenotype:0000295 name: thermotolerance_increased def: "Animals are able to survive for longer periods at temperatures above standard culture temperatures than control animals." [WB:WBPaper00005836, WB:WBPerson712] is_a: WBPhenotype:0000146 ! organism_temperature_response_variant [Term] id: WBPhenotype:0000296 name: spicules_crumpled def: "The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) are deformed. In C. elegans males there are two copulatory spicules." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000443 ! spicule_morphology_variant [Term] id: WBPhenotype:0000297 name: rays_fused alt_id: WBPhenotype:0001241 def: "Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are joined to one another." [WB:WBPerson2021, WB:WBPerson557] synonym: "ray_fusion" EXACT [] is_a: WBPhenotype:0000165 ! cell_fusion_variant is_a: WBPhenotype:0000199 ! male_tail_sensory_ray_development_variant is_a: WBPhenotype:0000505 ! male_ray_morphology_variant [Term] id: WBPhenotype:0000298 name: rays_displaced def: "Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are shifted from their customary place." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000505 ! male_ray_morphology_variant [Term] id: WBPhenotype:0000299 name: sensillum_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals." [WB:WBPaper00000214, WB:WBPaper00000938, WB:WBPerson712] synonym: "chemosensory_cell_morphology_abnormal" RELATED [] synonym: "sensillum_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000604 ! nervous_system_morphology_variant [Term] id: WBPhenotype:0000300 name: amphid_sheath_cell_morphology_variant def: "Animals exhibit variations in the structure or composition of the amphid sensillum cell that ensheathes the dendrite tips of channel neurons and wing cell dedritic processes, from that observed in control animals. Sheath cells in C.elegans have highly invaginated and vesiculated surfaces, which provide a specialized environment for the dendritic structures." [WB:WBPaper00000214, WB:WBPaper00000503, WB:WBPaper00000822, WB:WBPerson712] synonym: "amphid_sheath_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001527 ! amphid_phasmid_sensillum_morphology_variant [Term] id: WBPhenotype:0000301 name: distal_tip_cell_reflex_failure def: "A migrating distal tip cell (DTC) fails to follow the stereotypical path. In C. elegans this path is U-shaped and results in the formation of reflexed gonadal arm." [WB:WBPaper00029151, WB:WBPerson2021] is_a: WBPhenotype:0000195 ! distal_tip_cell_migration_variant [Term] id: WBPhenotype:0000302 name: benzaldehyde_chemotaxis_defective def: "Failure to execute the characteristic response to benzaldehyde as defined by control animals. In C.elegans benzaldehyde is typically attractive." [WB:WBPaper00001786] is_a: WBPhenotype:0001060 ! AWC_odorant_chemotaxis_defective is_a: WBPhenotype:0001468 ! benzaldehyde_chemotaxis_variant [Term] id: WBPhenotype:0000303 name: diacetyl_chemotaxis_defective def: "Failure to execute the characteristic response to diacetyl as defined by control animals. In C.elegans diacetyl is typically attractive." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001470 ! diacetyl_chemotaxis_variant [Term] id: WBPhenotype:0000304 name: isoamyl_alcohol_chemotaxis_defective def: "Failure to execute the characteristic response to isoamyl alcohol as defined by control animals. In C.elegans isoamyl alcohol is typically attractive." [WB:cab, WB:cgc1786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001472 ! isoamyl_alcohol_chemotaxis_variant [Term] id: WBPhenotype:0000305 name: pheromone_sensation_variant def: "Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that influences behavior in control animals." [GO:0043695, WB:WBPerson2021, WB:WBPerson557] synonym: "pheromone_sensation_abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0000306 name: transgene_expression_variant def: "Any variation in the characteristic expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to control animals." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "transgene_expression_abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene_expression_variant [Term] id: WBPhenotype:0000307 name: dauer_pheromone_sensation_defective def: "Animals fail to detect a pheromone stimulus that induces dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001479 ! dauer_pheromone_sensation_variant [Term] id: WBPhenotype:0000308 name: dauer_development_variant def: "Any variation in the processes that govern development of the dauer larva, a developmentally arrested, larval stage that is specialized for survival under harsh, or otherwise unfavorable, environmental conditions. In C. elegans this is an alternative third larval stage." [WB:kmva] synonym: "dauer_development_abnormal" NARROW [] is_a: WBPhenotype:0000049 ! postembryonic_development_variant [Term] id: WBPhenotype:0000309 name: SDS_sensitive_dauer def: "Any variation that decreases the ability of dauer larva to tolerate the exposure to detergents compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0001546 ! dauer_resistance_to_harsh_conditions_variant [Term] id: WBPhenotype:0000310 name: cilia_absent def: "Neurons lack the finger-like dendritic projections, which are observed extending from similar cells in control animals." [WB:WBPaper00000932, WB:WBPerson712] is_a: WBPhenotype:0000615 ! cilia_morphology_variant [Term] id: WBPhenotype:0000312 name: dauer_pheromone_production_defective def: "Animals are incapable of synthesizing pheromones that induce dauer formation in control animals." [GO:0042446, WB:WBPerson2021] is_a: WBPhenotype:0000191 ! organism_crowding_response_variant is_a: WBPhenotype:0001547 ! dauer_metabolism_variant [Term] id: WBPhenotype:0000313 name: meiotic_progression_during_oogenesis_variant def: "Oocytes show defects in their initial entry or progression through the meiotic pathway (such as failure to exit diakinesis)." [WB:WBPaper00026997, WB:WBPerson2021] synonym: "meiotic_progression_during_oogenesis_abnormal" NARROW [] is_a: WBPhenotype:0000186 ! oogenesis_variant [Term] id: WBPhenotype:0000314 name: scrawny def: "Animals are slight or meager in body size compared to control animals at the same developmental stage." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000231 ! body_size_variant [Term] id: WBPhenotype:0000315 name: mechanosensation_variant alt_id: WBPhenotype:0000513 def: "Any variation with respect to perception or response to mechanical stimuli compared to control animals." [WB:cab] subset: phenotype_slim_wb synonym: "Mec" BROAD three_letter_name [] synonym: "mechanosensation_abnormal" NARROW [] synonym: "touch_response_abnormal" EXACT [] is_a: WBPhenotype:0000525 ! organism_behavior_variant is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0000316 name: touch_resistant_tail def: "Failure to execute a characteristic response when struck or stroked in the posterior region. In C. elegans animals move forward movement when struck or stroked in the posterior region, usually with a hair or similar fiber. The posterior region lies between the vulva and the tail." [WB:WBPaper00000502, WB:WBPaper00001133, WB:WBPaper00001705, WB:WBPerson557] synonym: "touch_insensitive_tail" RELATED [] synonym: "touch_resistant_posterior_body" BROAD [] is_a: WBPhenotype:0000456 ! touch_resistant [Term] id: WBPhenotype:0000317 name: head_withdrawal_defective def: "Animals are deficient in the foraging response in which an animal quickly pulls its head away from a stimulus to the nose (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000315 ! mechanosensation_variant [Term] id: WBPhenotype:0000318 name: cell_cycle_delayed def: "Cells of the animals proceed through their replicative phase at a pace slower than observed for control cells." [WB:WBPerson712] is_a: WBPhenotype:0000740 ! cell_cycle_variant [Term] id: WBPhenotype:0000319 name: large alt_id: WBPhenotype:0000348 def: "Animals have increased girth and increased length compared to control animals at the same developmental stage." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_size_enlarged" EXACT [] is_a: WBPhenotype:0000231 ! body_size_variant [Term] id: WBPhenotype:0000320 name: reduced_viability_after_freezing def: "Animals show a decrease in survivorship after thawing compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000141 ! stress_induced_lethality_increased [Term] id: WBPhenotype:0000321 name: nose_morphology_variant def: "Animals exhibit variations in the form, structure or composition of any portion of the \nextreme anterior part of their body compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "nose_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000071 ! head_morphology_variant [Term] id: WBPhenotype:0000322 name: nose_rounded def: "The extreme anterior part of the body appears blunted in shape." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000321 ! nose_morphology_variant [Term] id: WBPhenotype:0000323 name: head_swollen def: "The most anterior portion of the animal appears bloated or distended." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000071 ! head_morphology_variant [Term] id: WBPhenotype:0000324 name: short def: "Animals exhibit a decreased body length compared to control animals of the same developmental stage." [WB:WBPerson712] is_a: WBPhenotype:0001726 ! body_length_variant [Term] id: WBPhenotype:0000325 name: arecoline_hypersensitive def: "Animals respond to arecoline at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001579 ! cholinergic_agonist_hypersensitive [Term] id: WBPhenotype:0000326 name: arecoline_resistant def: "Animals fail to respond to the concentration of arecoline that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001578 ! cholinergic_agonist_resistant [Term] id: WBPhenotype:0000327 name: corpus_contraction_defect def: "Any defect in the muscle contractions of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000747 ! pharyngeal_contraction_defective [Term] id: WBPhenotype:0000328 name: terminal_bulb_contraction_variant def: "Variations in the rhythmic contractions of the posterior pharynx (terminal bulb), such as timing, strength etc. In C. elegans contraction of the terminal bulb inverts the grinder, allowing bacteria in front of the grinder to be broken up and transported to the intestine." [WB:WBPaper00001696] synonym: "terminal_bulb_contraction_abnormal" NARROW [] is_a: WBPhenotype:0000980 ! pharyngeal_contraction_variant [Term] id: WBPhenotype:0000329 name: pumping_asynchronous def: "The rhythmic contractions of pharyngeal compartments are no longer synchronized compared to control. In C. elegans the corpus and terminal bulb normally contract simultaneously." [WB:WBPaper00001696] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_variant [Term] id: WBPhenotype:0000330 name: pharyngeal_relaxation_defective def: " Defects in rhythmic pharyngeal relaxations compared to control animals. In C. elegans pharyngeal relaxation follows a contraction event and facilitates bacterial trapping within the pharynx while expelling liquid." [WB:WBPaper00001709] is_a: WBPhenotype:0001004 ! pharyngeal_relaxation_variant [Term] id: WBPhenotype:0000331 name: inhibitors_of_na_k_atpase_resistant def: " Animals fail to respond to the concentration of sodium potassium ATPase antagonists that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson2021] synonym: "ouabain resistant" NARROW [] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000332 name: inhibitors_of_sodium_potassium_ATPase_hypersensitive def: "Animals respond to inhibitors of sodium potassium ATPase at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000333 name: pharyngeal_pumps_brief def: "The time interval of the stereotyped sequence of muscle contractions by individual pharyngeal muscles that act to draw food into the pharynx is shorter compared to that observed in control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_variant [Term] id: WBPhenotype:0000334 name: isthmus_corpus_slippery def: "Failure of muscle contractions in the corpus and isthmus to trap and transport bacteria posteriorly in the pharynx." [WB:WBPaper00001696] is_a: WBPhenotype:0000335 ! pharynx_slippery [Term] id: WBPhenotype:0000335 name: pharynx_slippery def: "Failure of pharyngeal contractions to trap and transport bacteria posteriorly. In C. elegans this defect results in a distention of the pharyngeal lumen " [WB:WBPaper00001696] is_a: WBPhenotype:0000634 ! pharyngeal_pumping_variant [Term] id: WBPhenotype:0000336 name: terminal_bulb_relaxation_variant def: "Variations in the rhythmic relaxations of the posterior pharynx (terminal bulb). In C. elegans the relaxation of the terminal bulb returns the grinder to its relaxed forward position." [WB:WBPaper00001696] synonym: "terminal_bulb_relaxation_abnormal" NARROW [] relationship: part_of WBPhenotype:0000330 ! pharyngeal_relaxation_defective [Term] id: WBPhenotype:0000337 name: grinder_relaxation_defective def: "Failure of the grinder to come to a full relaxed position between pumps compared to control." [WB:WBPaper00001709] is_a: WBPhenotype:0001480 ! grinder_relaxation_variant [Term] id: WBPhenotype:0000338 name: tail_swelling def: "Swelling in the post anal region compared to control. In C. elegans this swelling can be associated with infection from the nematode-specific bacterial pathogen, Microbacterium nematophilum." [WB:cab, WB:WBPaper00026735] synonym: "Dar" BROAD three_letter_name [] synonym: "deformed_anal_region" RELATED [] is_a: WBPhenotype:0000073 ! tail_morphology_variant [Term] id: WBPhenotype:0000339 name: transient_bloating def: "Worms sporatically appear turgid or swollen as a result of an excess number of eggs being retained in the uterus." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000862 ! bloated [Term] id: WBPhenotype:0000340 name: imipramine_resistant def: "Animals fail to respond to the concentration of imipramine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0001598 ! inhibitor_of_serotonin_uptake_variant [Term] id: WBPhenotype:0000341 name: imipramine_hypersensitive def: "Animals respond to imipramine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000342 name: bursa_morphology_variant def: "Any variation in the form, structure or composition of the adult male tail including the lateral fan and rays compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "bursa_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000070 ! male_tail_morphology_variant [Term] id: WBPhenotype:0000344 name: cloacal_structures_protrude def: "Any of the contents that comprise the epithelial chamber that links the genital and alimentary tracts to the exterior via the anus extend into the external environment through the cloacal opening." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000908 ! cloacal_morphology_variant [Term] id: WBPhenotype:0000345 name: VPC_cell_division_variant def: "Any variation that alters the physical partitioning and separation of a vulval precursor cell into daughter cells compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "VPC_cell_division_abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0000346 name: adult_pigmentation_variant def: "Adult animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals." [WB:WBPerson557] synonym: "adult_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0001009 ! developmental_pigmentation_variant [Term] id: WBPhenotype:0000347 name: rectal_development_variant def: "Any variation in the progression of the cuticle-lined sinus opening on the posterior ventral surface of the animal over time from its formation to its mature structure compared to control (Wormatlas). The function of the rectum is to excrete waste products from the alimentary system." [WB:WBPerson2021, WB:WBPerson557] synonym: "rectal_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_variant [Term] id: WBPhenotype:0000349 name: flaccid def: "A semi-paralysed body phenotype in which muscle tone is lost and the animal fails to actively control its body shape (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "floppy" RELATED [] synonym: "limp" RELATED [] is_a: WBPhenotype:0000001 ! body_posture_variant [Term] id: WBPhenotype:0000350 name: hermaphrodite_tail_spike_variant def: "Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the hermaphrodite tail compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000968 ! tail_spike_variant [Term] id: WBPhenotype:0000351 name: failure_to_hatch def: "Animals fail to emerge from an egg shell." [GO:0035188, WB:WBPerson2021] is_a: WBPhenotype:0000048 ! hatching_variant is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0000352 name: backing_uncoordinated def: "Backward movement is not coordinated as in control. This often causes jerky or spastic backward locomotion." [WB:WBPaper00001709] is_a: WBPhenotype:0001005 ! backward_locomotion_variant [Term] id: WBPhenotype:0000353 name: backing_increased def: "Animals spend more time backing compared to control animals." [WB:cab] is_a: WBPhenotype:0001005 ! backward_locomotion_variant [Term] id: WBPhenotype:0000354 name: cell_differentiation_variant def: "Variations in the processes leading to the specialization of cell. Differentiation impacts diverse cellular properties such as size, shape, polarity, gene expression and responsiveness to signals/cues." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell_differentiation_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000355 name: HSN_differentiation_precocious def: "Specialization of HSN precursor cells to mature HSN neurons occurs at an earlier stage of development compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000354 ! cell_differentiation_variant [Term] id: WBPhenotype:0000356 name: spermatogenesis_delayed def: "The progression of immature germ cells to functional sperm is retarded compared to control." [WB:WBPaper00005566, WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis_variant [Term] id: WBPhenotype:0000357 name: unfertilized_oocytes_laid def: "Animals lay inactivated oocytes. In C elegans this may be due to perturbations that eliminate spermatogenesis or result in the production of defective sperm." [WB:WBPaper00001075, WB:WBPerson2021] is_a: WBPhenotype:0000640 ! egg_laying_variant [Term] id: WBPhenotype:0000358 name: extra_cell_division_postembryonic def: "Animals execute supernumerary cell divisions post-hatching." [WB:WBPerson2021, WB:WBPerson557] synonym: "supernumerary_cell_divisions" RELATED [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000359 name: tunicamycin_response_variant def: "Animals exhibit variations in the response to the addition of tunicamycin compared to that observed in control animals. Tunicamycin induces the unfolded protein response." [WB:WBPaper00030877, WB:WBperson557] synonym: "tunicamycin_response_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0000360 name: cytoplasmic_streaming_defective def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell is impaired." [GO:0016482, WB:WBPerson2021, WB:WBPerson557] comment: Possible XP is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000361 name: lima_bean_arrest def: "Cessation of development at an intermediate stage in embryogenesis, immediately following the completion of gastrulation. In C. elegans this occurs around 350-390 minutes after first cleavage, cell number is at approximately 560 cells. At this time cell proliferation ceases and the embryo begins morphogenesis and elongation. The shape of the entire embryo within the eggshell resembles a lima bean (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "arrest_during_epiboly" RELATED [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000867 ! embryonic_arrest [Term] id: WBPhenotype:0000362 name: blastocoel_variant def: "Any variation in the progression of the fluid-filled compartment inside the developing embryo at the onset of gastrulation over time from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "blastocoel_abnormal" NARROW [] is_a: WBPhenotype:0000047 ! gastrulation_variant [Term] id: WBPhenotype:0000363 name: cell_division_slow def: "Any variation that delays the physical partitioning and separation of a cell into daughter cells compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0000364 name: gut_granule_birefringence_misplaced def: "The birefringent inclusions typically found in the intestinal cytoplasm accumulate extracellularly in the intestinal lumen. " [WB:WBPaper00025094] relationship: part_of WBPhenotype:0000902 ! intestinal_cell_morphology_variant [Term] id: WBPhenotype:0000365 name: embryo_osmotic_integrity_defective_early_emb def: "Variations in the ability of an embryo to maintain osmotic balance. In C.elegans this can result in an embryo filling the egg shell and lysing." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] synonym: "embryo_osmotic_integrity_abnormal" NARROW [] is_a: WBPhenotype:0000041 ! osmotic_integrity_variant is_a: WBPhenotype:0001178 ! egg_integrity_defective_early_emb [Term] id: WBPhenotype:0000366 name: three_fold_arrest def: "Cessation of development that normally occurs in C. elegans 520-620min after the first cleavage at 20C, the stage between the 2-fold and fully elongated embryo." [WB:WBPerson101] synonym: "active_elongation_arrest" RELATED [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000779 ! late_embryonic_arrest [Term] id: WBPhenotype:0000367 name: comma_arrest_emb def: "Cessation of development during the middle stage in embryogenesis of the worm in which the embryo is slightly folded within the eggshell (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD three_letter_name [] synonym: "end_of_epiboly_arrest" RELATED [] is_a: WBPhenotype:0000864 ! early_elongation_arrest [Term] id: WBPhenotype:0000368 name: one_point_five_fold_arrest_emb def: "Cessation of development that normally occurs in C. elegans 420-460 min after the first embryonic cleavage at 20C, the stage between the comma and 2-fold embryo." [WB:WBPerson101] synonym: "arrest_beginning_elongation" RELATED [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000864 ! early_elongation_arrest [Term] id: WBPhenotype:0000369 name: pretzel_arrest def: "Cessation of development during the final two stages in embryogenesis, 'early pretzel' stage and 'late pretzel' stage, just prior to hatching. The animal now is folded into four lengths within the eggshell and resembles a pretzel. By early pretzel stage, the head begins to move independently from the body (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD three_letter_name [] synonym: "end_of_elongation_arrest" RELATED [] is_a: WBPhenotype:0000779 ! late_embryonic_arrest [Term] id: WBPhenotype:0000370 name: egg_long def: "The fertilized oocytes have a greater than standard length measured end to end compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000037 ! egg_morphology_variant [Term] id: WBPhenotype:0000371 name: cell_division_incomplete def: "The physical partitioning and separation of a cell into daughter cells is interupted." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0000372 name: no_polar_body_formation def: "Animals lack the two small cells produced, each during one of the two meiotic cell divisions (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000775 ! meiosis_variant [Term] id: WBPhenotype:0000373 name: egg_shape_variable def: "The overall structure or appearance of fertilized oocytes that are laid exhibit nonconsistent and significant deviation from that of control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000037 ! egg_morphology_variant [Term] id: WBPhenotype:0000374 name: early_divisions_prolonged def: "The time interval in which early embryonic cell divisions occur is increased compared to control. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000375 name: later_divisions_prolonged def: "The time interval in which late embryonic cell divisions occur is increased compared to control. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000376 name: no_uterine_cavity def: "Animals lack the inner space of the uterus through which the fertilized egg passes on its way out of the nematode via the vulva (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000289 ! uterus_morphology_variant [Term] id: WBPhenotype:0000377 name: canal_lumen_morphology_variant def: "Animals exhibit variations in the form, structure or composition of the internal space of the excretory canal compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "canal_lumen_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000704 ! excretory_canal_morphology_variant [Term] id: WBPhenotype:0000378 name: pharyngeal_pumping_shallow def: "Pharyngeal muscle contractions show less displacement than that observed in control animals. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000634 ! pharyngeal_pumping_variant [Term] id: WBPhenotype:0000379 name: head_notched def: "The most anterior portion of the animal contains a V-shaped indentation." [WB:WBPaper00000031] is_a: WBPhenotype:0000071 ! head_morphology_variant [Term] id: WBPhenotype:0000380 name: expulsion_infrequent def: "The final step of the defecation motor program does not occur at each cycle, but is activated occasionally. During this step in C. eslegans specialized enteric muscles contract to expel the contents of the gut through the anus." [WB:WBPaper00002315, WB:WBPerson712] is_a: WBPhenotype:0000996 ! expulsion_defective [Term] id: WBPhenotype:0000381 name: serotonin_reuptake_inhibitor_resistant def: "Animals fail to respond to the concentration of serotonin reuptake inhibitors that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000382 name: serotonin_reuptake_inhibitor_hypersensitive def: "Animals respond to serotonin reuptake inhibitors at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000383 name: lipid_synthesis_defective def: "The de novo synthesis of any lipid species is reduced compared to that observed in control animals." [WB:WBPerson712] synonym: "lipid_synthesis_decreased" RELATED [] is_a: WBPhenotype:0000725 ! lipid_metabolism_variant [Term] id: WBPhenotype:0000384 name: axon_guidance_variant def: "Variations in the cue-directed extension of an axon towards a specific target site compared to control. (Axon guidance often depends on a combination of attractive and repulsive cues)." [GO:0048846, WB:WBPerson2021] synonym: "axon_guidance_abnormal" NARROW [] synonym: "axon_pathfinding_abnormal" RELATED [] is_a: WBPhenotype:0001224 ! axon_outgrowth_variant [Term] id: WBPhenotype:0000385 name: sperm_excess def: "Animals produce an increased sperm population compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis_variant [Term] id: WBPhenotype:0000386 name: genotoxic_induced_apoptosis_variant def: "Programmed cell death of germ cells caused by exposure to ionizing energy does not occur to the same extent as it does in control animals." [WB:WBPaper00032006, WB:WBPaper00032243, WB:WBPaper00032356, WB:WBPerson712] synonym: "DNA_damage_induced_apoptosis_abnormal" RELATED [] synonym: "genotoxic_induced_apoptosis_abnormal" NARROW [] is_a: WBPhenotype:0000730 ! apoptosis_variant [Term] id: WBPhenotype:0000387 name: sperm_nonmotile def: "The mature male gametes lack self-propelled movement." [GO:0030317, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000987 ! germ_cell_physiology_variant [Term] id: WBPhenotype:0000388 name: sperm_morphology_variant def: "Any variation in the form, structure or composition of the mature male gamete, which merges with an oocyte to create a fertilized embryo copared to control (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "sperm_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000900 ! germ_cell_morphology_variant [Term] id: WBPhenotype:0000389 name: hermaphrodite_sperm_fertilization_defective def: "Any perturbation that renders hermaphrodite derived sperm incompetent at fertilizing an oocyte." [WB:WBPaper00001075, WB:WBPerson2021] is_a: WBPhenotype:0000694 ! hermaphrodite_sterile [Term] id: WBPhenotype:0000390 name: spermatid_activation_defective def: "Spermatids fail to mature into active sperm. In C. elegans round sessile spermatids mature into spermatozoa (polarized cells with a motile pseudopod), upon copulation or treatment with proteases." [WB:WBPaper00000884, WB:WBPaper00027300, WB:WBPerson2021] synonym: "spermiogenesis defective " RELATED [] is_a: WBPhenotype:0000670 ! spermatogenesis_variant [Term] id: WBPhenotype:0000391 name: defecation_missing_motor_steps def: "Animals lack one or more of the stereotyped muscle contractions that result in defecation compared to control. In C. elegans these contractions include posterior body contraction (pBoc), anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000650 ! defecation_variant [Term] id: WBPhenotype:0000392 name: intestinal_fluorescence_increased def: "Animals exhibit an increase in the accumulation or expression of biochromes or any other substances that fluoresce in the intestine." [WB:WBPerson557] relationship: part_of WBPhenotype:0000293 ! alimentary_system_pigmentation_variant [Term] id: WBPhenotype:0000393 name: cell_migration_failure def: "Characteristic movement of cells from one site to another is abolished compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000594 ! cell_migration_variant [Term] id: WBPhenotype:0000394 name: electrophoretic_variant_protein def: "Any variation in the movement of a protein through a gel matrix when an electric field is applied compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000112 ! protein_expression_variant [Term] id: WBPhenotype:0000395 name: no_differentiated_gametes def: "Animals are agametic (lack mature germ cells)." [WB:WBPerson2021] is_a: WBPhenotype:0000894 ! germ_cell_differentiation_variant [Term] id: WBPhenotype:0000396 name: non_reflexed_gonad_arms def: "Gonadal arms do not bend or curve. In C. elegans gonad arms normally reflex to form a stereotypical U-shaped pattern." [WB:WBPaper00005086, WB:WBPaper00029151, WB:WBPerson2021] is_a: WBPhenotype:0000399 ! somatic_gonad_development_variant [Term] id: WBPhenotype:0000397 name: harsh_body_touch_resistant def: "Animals do not respond to prodding with a fine platinum wire or similar tool compared to controls." [WB:WBPaper00000502] synonym: "harsh_body_touch_insensitive" RELATED [] is_a: WBPhenotype:0000456 ! touch_resistant [Term] id: WBPhenotype:0000398 name: light_body_touch_resistant def: "Animals do not respond to stroking to the head or tail with a hair or similar fiber, but does respond to stronger mechanical stimuli such as prodding with a fine platinum wire or similar tool compared to controls." [WB:WBPaper00000502] synonym: "light_body_touch_insensitive" RELATED [] is_a: WBPhenotype:0000456 ! touch_resistant [Term] id: WBPhenotype:0000399 name: somatic_gonad_development_variant def: "Any variation in the progression of the components of the gonad that are separate from the germline proper over time from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "somatic_gonad_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000691 ! gonad_development_variant [Term] id: WBPhenotype:0000400 name: somatic_gonad_primordium_development_defective def: "The developmental progression of the set of precursor cells that later give rise to the somatic tissues of the gonadal tract is impaired (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000399 ! somatic_gonad_development_variant [Term] id: WBPhenotype:0000401 name: no_uterus def: "Animals lack the portion of the somatic gonad which encloses the fertilized eggs after their passage through the spermatheca (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000624 ! reproductive_system_development_variant [Term] id: WBPhenotype:0000402 name: avoids_bacterial_lawn def: "Lawn avoidance refers to behavior in which animals initially enter the bacterial lawn but later exit and remain near the edge of the bacteria. Lawn avoidance is often a response to bacterial food, that is pathogenic or low quality to the animal." [WB:WBPaper00029071, WB:WBPerson2021] is_a: WBPhenotype:0000659 ! feeding_behavior_variant [Term] id: WBPhenotype:0000403 name: sperm_transfer_initiation_defective def: "Any defect in the movement of sperm out of the seminal vesicle and into the vas deferens following tonic insertion of spicules into the mating partner compared to control." [WB:WBPaper00028400] is_a: WBPhenotype:0000284 ! sperm_transfer_defective [Term] id: WBPhenotype:0000404 name: delayed_hatching def: "The emergence of larvae from their protective egg shells is retarded compared to control animals." [GO:0035188, WB:WBPerson2021] is_a: WBPhenotype:0000048 ! hatching_variant [Term] id: WBPhenotype:0000405 name: giant_oocytes def: "The size of haploid female germ cells (oocytes) are significantly larger compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001260 ! oocyte_morphology_variant [Term] id: WBPhenotype:0000406 name: lumpy def: "Animals have protrusions or bumps on their exterior which are not characteristic of control animals." [WB:WBPerson557] is_a: WBPhenotype:0000535 ! organism_morphology_variant [Term] id: WBPhenotype:0000408 name: dauer_recovery_inhibited def: "The process through which a dauer larva reverts to normal developmental programs is blocked." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000127 ! dauer_recovery_variant [Term] id: WBPhenotype:0000409 name: organism_morphology_variable def: "Animals exhibit variations in the form, structure or composition of any of its parts at different stages of the lifecycle, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "Vab" BROAD three_letter_name [] is_a: WBPhenotype:0000535 ! organism_morphology_variant [Term] id: WBPhenotype:0000410 name: no_defecation_cycle def: "Animals lack the stereotyped sequence of muscle contractions that result in defecation over a fixed time period compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000207 ! defecation_cycle_variant [Term] id: WBPhenotype:0000411 name: rod_like_larval_lethal def: "Animals die as rigid, rod-like larva. In C. elegans this defect is often caused by the misspecification of the excretory duct cell." [WB:WBPaper00001366, WB:WBPaper00002764, WB:WBPerson2021] synonym: "Let" RELATED [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000035 ! larval_body_morphology_variant is_a: WBPhenotype:0000054 ! larval_lethal [Term] id: WBPhenotype:0000412 name: octanol_chemotaxis_defective def: "Failure to execute the characteristic response to 1-octanol as defined by control animals. In C.elegans 1-octanol is typically a repellant." [WB:WBPaper00002314] is_a: WBPhenotype:0001448 ! odorant_negative_chemotaxis_defective is_a: WBPhenotype:0001452 ! octanol_chemotaxis_variant [Term] id: WBPhenotype:0000413 name: pharyngeal_muscle_paralyzed def: "Pharyngeal muscle is immobilized resulting in lack of pumping or lack of response to external stimulation." [WB:cab, WB:WBPerson557] is_a: WBPhenotype:0000980 ! pharyngeal_contraction_variant [Term] id: WBPhenotype:0000414 name: cell_fate_transformation def: "The cell takes on a different identity from which it was initially committed." [GO:0045165, WB:WBPaper00002924, WB:WBPerson712] is_a: WBPhenotype:0000216 ! cell_fate_specification_variant [Term] id: WBPhenotype:0000415 name: necrotic_cell_death_variant def: "Animals exhibit variations in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control." [GO:0070265, WB:WBPerson712] synonym: "necrotic_cell_death_abnormal" NARROW [] is_a: WBPhenotype:0001173 ! non_apoptotic_cell_death_variant [Term] id: WBPhenotype:0000416 name: yolk_synthesis_variant def: "Variations in the generation of the nutrient protein produced by intestinal cells and secreted by them into the pseudocoelom, from which it can be shared with other tissues in the body compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "vitellogenin_synthesis_abnormal" RELATED [] synonym: "yolk_synthesis_abnormal" NARROW [] is_a: WBPhenotype:0001093 ! intestinal_physiology_variant [Term] id: WBPhenotype:0000417 name: cell_division_failure def: "The process of physical partitioning and separation of a cell into daughter cells is abolished." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0000418 name: intestinal_cell_division_failure def: "The physical partitioning and separation of an intestinal cell into daughter cells is abolished." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000417 ! cell_division_failure [Term] id: WBPhenotype:0000419 name: L3_lethal def: "Animals die at the L3 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000058 ! late_larval_lethal is_a: WBPhenotype:0000116 ! mid_larval_lethal [Term] id: WBPhenotype:0000420 name: levamisole_hypersensitive def: " Animals respond to levamisole at a lower concentration or a shorter exposure compared to control animals. Levamisole is a cholinergic agonist." [WB:WBPerson557] synonym: "tetramisole_hypersensitive" RELATED [] is_a: WBPhenotype:0000845 ! levamisole_response_variant is_a: WBPhenotype:0001579 ! cholinergic_agonist_hypersensitive [Term] id: WBPhenotype:0000421 name: levamisole_resistant def: "Animals fail to respond to the concentration of levamisole that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans resistance to levamisole is often assayed via body contraction response, ventral tail curling response etc." [WB:WBPaper00000484, WB:WBPerson2021] synonym: "tetramisole_resistant" RELATED [] is_a: WBPhenotype:0000845 ! levamisole_response_variant is_a: WBPhenotype:0001578 ! cholinergic_agonist_resistant [Term] id: WBPhenotype:0000422 name: twitcher def: "Animals exhibit spasmodic muscle twitching superimposed on normal sinusoidal motion." [WB:WBPaper00000484] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000423 name: head_muscle_contraction_variant def: "Any variation in the contractions of the muscles in the most anterior body region of the animal compared to control." [WB:WBPerson557] synonym: "head_muscle_contraction_abnormal" NARROW [] is_a: WBPhenotype:0000611 ! muscle_system_physiology_variant [Term] id: WBPhenotype:0000424 name: antibody_staining_variant def: "Any variation in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "antibody_staining_abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein_expression_variant [Term] id: WBPhenotype:0000425 name: antibody_staining_reduced def: "Any variation that results in a decrease in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000424 ! antibody_staining_variant [Term] id: WBPhenotype:0000426 name: antibody_staining_increased def: "Any variation that results in an increase in the characteristic expression of a gene product, as detected by antibody staining, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000424 ! antibody_staining_variant [Term] id: WBPhenotype:0000427 name: no_cuticle def: "Animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000201 ! cuticle_development_variant [Term] id: WBPhenotype:0000428 name: no_adult_cuticle def: "Adult animals lack the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000427 ! no_cuticle [Term] id: WBPhenotype:0000429 name: copulatory_structure_development_variant def: "Any variation in the progression of the specialized structures of the animal which allow the successful transfer of sperm from one organism to another, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "copulatory_structure_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_variant [Term] id: WBPhenotype:0000430 name: male_copulatory_structure_development_variant def: "Any variation in the progression of the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm over time from its formation to its mature structure compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_copulatory_structure_development_abnormal" NARROW [] is_a: WBPhenotype:0000429 ! copulatory_structure_development_variant [Term] id: WBPhenotype:0000431 name: hermaphrodite_copulatory_structure_development_variant def: "Any variation in the progression of the specialized structures of a hermaphrodite which allow the successful transfer of sperm from a male, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite_copulatory_structure_development_abnormal" NARROW [] is_a: WBPhenotype:0000429 ! copulatory_structure_development_variant [Term] id: WBPhenotype:0000432 name: male_copulatory_structure_absent def: "Animals lack the specialized structures of the male tail which allow the animal to sense the presence of the hermaphrodite, search her body for the vulval opening, grasp onto the vulva, and to transfer sperm (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000430 ! male_copulatory_structure_development_variant [Term] id: WBPhenotype:0000433 name: DNA_synthesis_variant def: "Variations in the processes involving the production of new DNA strands compared to control." [GO:0006260, WB:WBPerson2021] synonym: "DNA_synthesis_abnormal" NARROW [] is_a: WBPhenotype:0000732 ! DNA_metabolism_variant [Term] id: WBPhenotype:0000434 name: sexual_maturation_defective def: "The developmental process by which a progressive change in the state of some part of an organism specifically contributing to its ability to form offspring is impaired." [GO:0003006, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000624 ! reproductive_system_development_variant [Term] id: WBPhenotype:0000436 name: protein_subcellular_localization_variant alt_id: WBPhenotype:0000435 def: "Any variation in the placement of a protein within in a cell or cellular compartment compared to control." [WB:WBPerson557] synonym: "protein_localization_abnormal" EXACT [] synonym: "protein_subcellular_localization_abnormal" NARROW [] is_a: WBPhenotype:0001408 ! pattern_protein_expression_variant [Term] id: WBPhenotype:0000438 name: retarded_heterochronic_variations def: "Variations that result in the deceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control." [GO:0040034, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000033 ! developmental_timing_variant [Term] id: WBPhenotype:0000439 name: precocious_heterochronic_variations def: "Variations that result in the acceleration of the rate, frequency or extent of the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, compared to control." [GO:0040034, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000033 ! developmental_timing_variant [Term] id: WBPhenotype:0000440 name: excretory_canals_long def: "The structure made by the processes of the excretory canal cell is increased in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "long_excretory_canals" RELATED [] relationship: part_of WBPhenotype:0000704 ! excretory_canal_morphology_variant [Term] id: WBPhenotype:0000441 name: tail_rounded def: "Tails change shape and undergo retraction thereby forming a 'peloderan' or 'rounded' adult tail." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000073 ! tail_morphology_variant [Term] id: WBPhenotype:0000442 name: larval_development_retarded def: "The developmental progression of a larva over time, from its formation to its mature structure is delayed compared to control. The larva is the early, immature form of an animal between hatching and adulthood." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000750 ! larval_development_variant [Term] id: WBPhenotype:0000443 name: spicule_morphology_variant def: "Any variation in the appearance of the elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "spicule_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001024 ! male_morphology_variant [Term] id: WBPhenotype:0000444 name: bursa_elongated def: "The length of the adult male tail, including the lateral fan and rays, is extended compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000342 ! bursa_morphology_variant [Term] id: WBPhenotype:0000445 name: yolk_synthesis_in_males def: "Males generate yolk, the nutrient protein, normally produced and secreted by hermaphrodite or female intestinal cells." [WB:WBPerson2021, WB:WBPerson557] synonym: "vitellogenin_synthesis_in_males" RELATED [] is_a: WBPhenotype:0000416 ! yolk_synthesis_variant [Term] id: WBPhenotype:0000446 name: supernumerary_molt def: "Animals execute extra larval molts compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000447 name: adult_development_variant def: "Variations in the progression of an animal over time from the end of larval stage to a mature adult compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "adult_development_abnormal" NARROW [] is_a: WBPhenotype:0000049 ! postembryonic_development_variant [Term] id: WBPhenotype:0000448 name: adult_cuticle_development_variant def: "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) over time in adults compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "adult_cuticle_development_abnormal" NARROW [] is_a: WBPhenotype:0000447 ! adult_development_variant [Term] id: WBPhenotype:0000449 name: second_adult_cuticle def: "A duplication of the developmental program that forms the adult-type rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells." [WB:WBPaper00001439] is_a: WBPhenotype:0000448 ! adult_cuticle_development_variant [Term] id: WBPhenotype:0000451 name: head_protrusion def: "Any irregular swelling in discrete regions of the head." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000071 ! head_morphology_variant [Term] id: WBPhenotype:0000452 name: tail_protrusions def: "Any irregular swelling in discrete regions of the tail, usually caused by a local defect in the normal smooth tapering of the hypodermis and/or cuticle (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000073 ! tail_morphology_variant [Term] id: WBPhenotype:0000453 name: body_protrusions def: "Any irregular swelling in discrete regions of the body region between the head and the tail." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000072 ! body_morphology_variant [Term] id: WBPhenotype:0000454 name: head_twisted def: "The anterior end (which typically includes the anterior sensilla, pharynx and all muscles that are innervated by the nerve ring)of the body appears distorted, usually due to uncharacteristic winding." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000071 ! head_morphology_variant [Term] id: WBPhenotype:0000455 name: jerky_movement def: "Animals exhibit abrupt transitions while traveling from one location to another. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000456 name: touch_resistant def: "Variations in characteristic response with respect to perception or transmission of a touch stimulus compared to responses in control animals." [WB:WBPerson557] synonym: "touch_insensitive" RELATED [] is_a: WBPhenotype:0000315 ! mechanosensation_variant [Term] id: WBPhenotype:0000457 name: organism_starvation_hypersensitive def: "Animals show enhanced suceptibility to deprivation of nourishment, compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000147 ! organism_starvation_response_variant [Term] id: WBPhenotype:0000458 name: starvation_resistant def: "Animals show enhanced tolerance to deprivation of nourishment, compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000147 ! organism_starvation_response_variant [Term] id: WBPhenotype:0000459 name: pesticide_response_variant def: "Animals exhibit variations in their response to any chemical substance that is used for killing pests, compared to that observed in control animals." [WB:WBPerson557] synonym: "pesticide_response_abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0000460 name: paraquat_response_variant def: "Animals exhibit variations in their response to paraquat compared to that observed in control animals." [WB:WBPerson557] synonym: "methyl_viologen_response_abnormal" RELATED [] synonym: "paraquat_response_abnormal" NARROW [] is_a: WBPhenotype:0000068 ! oxidative_stress_response_variant is_a: WBPhenotype:0000459 ! pesticide_response_variant is_a: WBPhenotype:0001620 ! organism_oxidative_stress_response_variant [Term] id: WBPhenotype:0000461 name: paraquat_resistant def: "Animals fail to respond to the concentration of paraquat that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000460 ! paraquat_response_variant [Term] id: WBPhenotype:0000462 name: paraquat_hypersensitive def: "Animals respond to paraquat at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] synonym: "reactive_oxygen_species_hypersensitive" BROAD [WB:WBPaper00031296] is_a: WBPhenotype:0000460 ! paraquat_response_variant [Term] id: WBPhenotype:0000463 name: metabolic_pathway_variant def: "Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GO:0008152, WB:WBPerson712] synonym: "metabolic_pathway_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0000464 name: oxygen_response_variant def: "Animals exhibit variations in their response to oxygen compared to that observed in control animals." [WB:WBPerson557] synonym: "oxygen_response_abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0000465 name: high_oxygen_resistant def: "Animals fail to respond to the high concentrations of oxygen that elicit a response in control animals. " [WB:WBPerson2021] is_a: WBPhenotype:0000464 ! oxygen_response_variant [Term] id: WBPhenotype:0000466 name: high_oxygen_hypersensitive def: "Animals respond to hyperoxic (high oxygen tension) conditions after a shorter exposure time compared to control." [GO:0055093, WB:WBPerson2021] is_a: WBPhenotype:0000464 ! oxygen_response_variant [Term] id: WBPhenotype:0000467 name: age_associated_fluorescence_increased def: "Animals exhibit an increase in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control" [WB:WBPaper00033040, WB:WBPerson2021] is_a: WBPhenotype:0001009 ! developmental_pigmentation_variant [Term] id: WBPhenotype:0000468 name: age_associated_fluorescence_reduced def: "Animals exhibit a decrease in the intensity of fluorescence signals in intestinal cells with advancing age, compared to control" [WB:WBPerson2021] is_a: WBPhenotype:0001009 ! developmental_pigmentation_variant [Term] id: WBPhenotype:0000469 name: Q_neuroblast_lineage_migration_variant def: "The daughters of the Q neuroblasts exhibit variation in their characteristic movements compared to control animals." [WB:WBPaper00001954, WB:WBPaper00031356, WB:WBPerson712] synonym: "Q_neuroblast_lineage_migration_abnormal" NARROW [] is_a: WBPhenotype:0001140 ! neuron_migration_variant [Term] id: WBPhenotype:0000470 name: HSN_migration_variant def: "Any variation in the normal anterior movement of the HSN motor neurons from their birthplace in the tail to positions near the middle of the embryo compared to control animals." [WB:WBPaper00001836, WB:WBPerson2021] synonym: "HSN_migration_abnormal" NARROW [] is_a: WBPhenotype:0001229 ! anterior_neuron_migration_defective [Term] id: WBPhenotype:0000471 name: ALM_migration_variant def: "Any variation in the normal posterior movement of the ALM mechanosensory neurons from their birthplace (anterior to the V1 hypodermal cell) to positions in between the V2 and V3 cells in the embryo compared to control animals." [WB:WBPaper00001304, WB:WBPaper00003058, WB:WBPerson2021] synonym: "ALM_migration_abnormal" NARROW [] is_a: WBPhenotype:0001520 ! posterior_neuron_migration_variant [Term] id: WBPhenotype:0000472 name: endoderm_absent def: "Animals lack the early blast cells that give rise to the gut tissue (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000473 name: progressive_paralysis def: "Animals become increasingly sluggish/immobilized as they age." [WB:WBPaper00001709] is_a: WBPhenotype:0000644 ! paralyzed [Term] id: WBPhenotype:0000474 name: muscle_attachment_variant def: "Any variation in the connection of the cell(s) whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "muscle_attachment_abnormal" NARROW [] is_a: WBPhenotype:0000622 ! muscle_system_development_variant [Term] id: WBPhenotype:0000475 name: muscle_detached def: "Animals fail to establish or maintain the connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000474 ! muscle_attachment_variant [Term] id: WBPhenotype:0000476 name: progressive_muscle_detachment def: "The connection between cell(s) whose principal function is to provide contractile forces and its neighboring cells or tissues diminishes over time." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000474 ! muscle_attachment_variant [Term] id: WBPhenotype:0000477 name: nucleolus_refraction_variant def: "Any variation in the change in direction of a wave of light after passage through the nucleolus compared to control. The nucleolus is a small dense body in the nucleus." [WB:WBPerson2021, WB:WBPerson557] synonym: "nucleolus_refraction_abnormal" NARROW [] is_a: WBPhenotype:0000722 ! nucleolus_variant [Term] id: WBPhenotype:0000478 name: isothermal_tracking_behavior_variant def: "Variations in the ability of an animal to remain within a defined temperature. In C. elegans, animals tend to track and stay within a temperature that is most closely related to their cultivation temperature." [WB:WBPaper00002214] subset: phenotype_slim_wb synonym: "isothermal_tracking_behavior_abnormal" NARROW [] synonym: "thermotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000479 name: egg_pale def: "Eggs show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000970 ! embryonic_pigmentation_variant is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000480 name: pyrazine_chemotaxis_defective def: "Failure to execute the characteristic response to pyrazine as defined by control animals. In C. elegans pyrazine is typically an attractant." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001474 ! pyrazine_chemotaxis_variant [Term] id: WBPhenotype:0000481 name: negative_chemotaxis_variant def: "Any variation in the directed movement of an animal in response to chemical repellants as defined by control animals. " [GO:0050919, WB:cab] synonym: "chemical_avoidance_abnormal" RELATED [] synonym: "chemoaversion_abnormal" RELATED [] synonym: "negative_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001434 ! chemotaxis_variant [Term] id: WBPhenotype:0000482 name: garlic_chemotaxis_defective def: "Failure to execute the characteristic response to garlic as defined by control animals. In C. elegans, garlic is typically a repellent." [WB:WBPaper00001374] is_a: WBPhenotype:0001449 ! aqueous_negative_chemotaxis_defective is_a: WBPhenotype:0001451 ! garlic_chemotaxis_variant [Term] id: WBPhenotype:0000483 name: no_gut_granules def: "Animals lack the different inclusions within the intestinal cytoplasm, including birefringent crystalline objects and other dark-staining endosomes. In C. elegans these contents typically include glycogen granules (polysaccharide storage), rhabditin (carbohydrate storage), yolk granules (lipid and protein), and concentrated waste products (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000103 ! gut_granule_development_variant [Term] id: WBPhenotype:0000484 name: embryo_small def: "The organism's size during the embryonic developmental stage is decreased compared to that observed in control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001136 ! embryonic_morphology_variant [Term] id: WBPhenotype:0000485 name: dauer_death_increased def: "The survival of animals in the alternative larval stage which they enter when placed under conditions of environmental stress is reduced." [WB:WBPerson2021, WB:WBPerson557] synonym: "reduced_dauer_survival" RELATED [] is_a: WBPhenotype:0000159 ! dauer_arrest_variant [Term] id: WBPhenotype:0000486 name: colchicine_hypersensitive def: "Animals respond to colchicine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000487 name: colchicine_resistant def: "Animals fail to respond to the concentration of colchicine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000488 name: chloroquinone_hypersensitive def: "Animals respond to chloroquinone at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000489 name: chloroquinone_resistant def: "Animals fail to respond to the concentration of chloroquinone that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000490 name: pharynx_disorganized def: "The components of the feeding organ fail to be arranged in the same manner as control animals.\n" [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000707 ! pharyngeal_development_variant [Term] id: WBPhenotype:0000491 name: isthmus_morphology_defective def: "Any observed morphological defects of the isthmus." [WB:WBPerson2021] synonym: "isthmus_malformed" RELATED [] synonym: "isthmus_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000709 ! pharyngeal_morphology_variant [Term] id: WBPhenotype:0000492 name: corpus_morphology_defective def: "Any variation in the form, structure or composition of the extended anterior region of the pharynx lying just anterior to the isthmus and terminal bulb compared to control (Wormatlas)." [WB:WBPerson2021] synonym: "corpus_malformed" RELATED [] synonym: "corpus_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000709 ! pharyngeal_morphology_variant [Term] id: WBPhenotype:0000493 name: metacorpus_morphology_defective def: "Any variation in the form, structure or composition of the first pharyngeal bulb compared to control." [WB:WBPerson2021] synonym: "metacarpas_malformed" RELATED [] synonym: "metacorpus_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000709 ! pharyngeal_morphology_variant [Term] id: WBPhenotype:0000494 name: two_fold_arrest def: "Cessation of development that normally occurs in C. elegans 460-520 min after the first cleavage at 20C, the stage between the 1.5-fold and 3-fold embryo." [WB:WBPerson101] is_a: WBPhenotype:0000779 ! late_embryonic_arrest [Term] id: WBPhenotype:0000495 name: ray_ectopic def: "Animals have extra finger-like sensory sensilla that project from the tail and embed in the male fan compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000199 ! male_tail_sensory_ray_development_variant [Term] id: WBPhenotype:0000496 name: male_posterid_sensilla_absent def: "Males lack the specialized sensory papillae that lie along the the posterior half of the body." [WB:WBPerson2021, WB:WBPerson557] relationship: part_of WBPhenotype:0001008 ! male_nervous_system_development_variant [Term] id: WBPhenotype:0000497 name: organism_gamma_ray_response_variant def: "Animals exhibit variations in their response to gamma ray radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "organism_gamma_ray_response_abnormal" NARROW [] is_a: WBPhenotype:0000686 ! organism_ionizing_radiation_response_variant [Term] id: WBPhenotype:0000498 name: methyl_methanesulfonate_response_variant def: "Animals exhibit variations in their response to methyl methanesulfonate compared to that observed in control animals." [WB:WBPerson557] synonym: "methyl_methanesulfonate_response_abnormal" NARROW [] synonym: "MMS_response_abnormal" RELATED [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000499 name: ethyl_methanesulfonate_response_variant def: "Animals exhibit variations in their response to ethyl methanesulfonate (EMS) compared to that observed in control animals." [WB:WBPerson557] synonym: "EMS_response_abnormal" RELATED [] synonym: "ethyl_methanesulfonate_response_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000500 name: acetylcholinesterase_inhibitor_hypersensitive def: "Animals respond to an acetylcholinesterase inhibitor at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive is_a: WBPhenotype:0001290 ! acetylcholinesterase_inhibitor_response_variant [Term] id: WBPhenotype:0000501 name: left_handed_roller def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the left-handed direction. In liquid media, wave propogation is helical rather than planar." [WB:WBPerson2021, WB:WBPerson557] synonym: "Rol" RELATED [] is_a: WBPhenotype:0000645 ! roller [Term] id: WBPhenotype:0000502 name: right_handed_roller def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern in the right-handed direction. In liquid media, wave propogation is helical rather than planar." [WB:WBPerson2021, WB:WBPerson557] synonym: "Rol" BROAD three_letter_name [] is_a: WBPhenotype:0000645 ! roller [Term] id: WBPhenotype:0000503 name: endoreduplication_variant def: "Any variation in the multiple rounds of DNA replication that take place without chromosome condensation, segregation or cytokinesis compared to control. In C. elegans this process is normally seen in intestinal nuclei during each larval lethargus which results in adult intestinal nuclei with 32 copies (32C) of each chromosome(Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "endoreduplication_abnormal" NARROW [] is_a: WBPhenotype:0000732 ! DNA_metabolism_variant [Term] id: WBPhenotype:0000504 name: nuclear_division_variant def: "Any variation in the process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei, compared to control." [WB:WBPerson2021, WB:WBPerson557] comment: possible XP subset: phenotype_slim_wb synonym: "karyokinesis_abnormal" RELATED [] synonym: "nuclear_division_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000505 name: male_ray_morphology_variant def: "Animals exhibit variations in the structure or organization of any of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control animals. In C. elegans, nine bilateral rays project from the tail in a radial pattern with a smooth and slightly tapered appearance. Although one neuronal member of each ray sensillum is exposed to the outside, male rays rarely take up dye." [WB:WBPaper00000932, WB:WBPaper00001328, WB:WBPaper00002149, WB:WBPaper00029016, WB:WBPerson712] synonym: "male_ray_morphology_abnormal" NARROW [] synonym: "Ram" BROAD three_letter_name [] is_a: WBPhenotype:0000299 ! sensillum_morphology_variant relationship: part_of WBPhenotype:0001358 ! male_nervous_system_morphology_variant [Term] id: WBPhenotype:0000506 name: bursa_swollen alt_id: WBPhenotype:0000450 def: "The adult male tail, including the lateral fan and rays, appears bloated or distended." [WB:WBPerson2021, WB:WBPerson557] synonym: "swollen_male_tail" EXACT [] is_a: WBPhenotype:0000342 ! bursa_morphology_variant [Term] id: WBPhenotype:0000507 name: acetylcholine_levels_variant def: "Animals exhibit variations in the amount of acetylcholine compared to control animals at a defined stage. Acetylcholine is the acetic acid ester of the organic base choline." [WB:WBPerson2021, WB:WBPerson557] synonym: "acetylcholine_levels_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0000508 name: nonsense_mRNA_accumulation def: "Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail." [GO:0070478, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0000509 name: sperm_pseudopod_variant def: "Variation in the morphological appearance or composition of the pseudopod, a cellular projection that facilitates motility of the spermatozoa." [WB:WBPaper00001075, WB:WBPerson2021] synonym: "sperm_pseudopod_abnormal" NARROW [] is_a: WBPhenotype:0000388 ! sperm_morphology_variant [Term] id: WBPhenotype:0000510 name: vulval_invagination_variant_L4 alt_id: WBPhenotype:0000287 def: "The characteristic Christmas-tree shaped invagination formed by the terminal vulval cells at the mid-late L4 stage is altered." [WB:WBPaper00001738, WB:WBPerson2021] synonym: "vulval_invagination_abnormal" NARROW [] synonym: "vulval_invagination_L4_abnormal" NARROW [] synonym: "vulval_invagination_L4_variant" RELATED [] is_a: WBPhenotype:0000695 ! vulva_morphology_variant is_a: WBPhenotype:0000699 ! vulva_development_variant [Term] id: WBPhenotype:0000511 name: nuclear_positioning_variant def: "Variations in the directed movement of the nucleus to a specific location within a cell compared to control." [GO:0040023, WB:WBPerson2021, WB:WBPerson557] comment: possible XP subset: phenotype_slim_wb synonym: "nuclear_positioning_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000512 name: VNC_nuclear_positioning_variant def: "Variations in spacing or location were observed between adjacent ventral cord nuclei or between ventral cord nuclei and another nucleus used as a reference point. In C. elegans, these nuclei are distributed equally and predictably, such that they can be unambiguously distinguished by their position." [WB:WBPaper00031891, WB:WBPerson712] synonym: "VNC_nuclear_positioning_abnormal" NARROW [] is_a: WBPhenotype:0000511 ! nuclear_positioning_variant [Term] id: WBPhenotype:0000514 name: rubber_band def: "When prodded on the head, worm contracts and then relaxes along its entire body without moving backwards, compared to a control worm which contracts its anterior end and backs away in response to prodding. " [WB:WBPaper00006135, WB:WBPerson2021] is_a: WBPhenotype:0000315 ! mechanosensation_variant [Term] id: WBPhenotype:0000515 name: ventral_nerve_cord_development_variant def: "Variations in any process whose specific outcome is the development and/or maintenance of the ventral nerve cord." [WB:WBPerson557] synonym: "ventral_nerve_cord_development_abnormal" NARROW [] is_a: WBPhenotype:0000945 ! neuropil_development_variant [Term] id: WBPhenotype:0000516 name: ventral_cord_disorganized def: "The longitudinal nerve cord of the midbody region, connecting the nerve ring and tail ganglia, is not arranged in the same manner as control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000976 ! ventral_cord_patterning_variant [Term] id: WBPhenotype:0000517 name: behavior_variant def: "Variations in the specific actions or reactions in response to external or internal stimuli compared to that observed in control animals." [GO:0007610, WB:WBPerson557] synonym: "behavior_abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000518 name: development_variant def: "Variations in the progression of an integrated living unit (a cell, tissue, organ or organism) over time from an initial condition to a later condition compared to control animals." [GO:0032502, WB:WBPerson2021] synonym: "development_abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000519 name: physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the cell, tissue, organ system or organism to carry out its normal functions and activities or be able to perceive and respond to stimuli compared to control animals." [WB:WBPerson712] synonym: "physiology_abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000520 name: morphology_variant def: "Animals exhibit variations in the form, structure or composition of any of its parts compared to control animals." [WB:WBPerson712] synonym: "morphology_abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000521 name: pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency." [WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000886 ! Variant [Term] id: WBPhenotype:0000522 name: organism_region_behavior_variant def: "Variations in the specific actions or reactions of a certain defined body area of an animal in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism_region_behavior_abnormal" NARROW [] relationship: part_of WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000523 name: chemical_response_variant def: "Animals exhibit variations in their response to a specific chemical compared to that observed in control animals." [WB:WBPerson557] synonym: "chemical_response_abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0000524 name: bleach_response_variant def: "Animals exhibit variations in their response to bleach compared to that observed in control animals." [WB:WBPerson557] synonym: "bleach_response_abnormal" NARROW [] is_a: WBPhenotype:0001379 ! organism_toxic_chemical_response_variant [Term] id: WBPhenotype:0000525 name: organism_behavior_variant def: "Variations in the specific actions or reactions of an organism in response to external or internal stimuli compared to that observed in control organisms." [GO:0007610, WB:WBPerson557] subset: phenotype_slim_wb synonym: "organism_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000517 ! behavior_variant [Term] id: WBPhenotype:0000526 name: cell_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a cell." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "cell_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000521 ! pigmentation_variant [Term] id: WBPhenotype:0000527 name: organism_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "Abnormal_Coloration" RELATED [] synonym: "organism_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000521 ! pigmentation_variant [Term] id: WBPhenotype:0000528 name: body_region_development_variant def: "Variations in the progression of the overall structure or appearance of a discrete region of an animal's anatomy over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_region_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000531 ! organism_development_variant [Term] id: WBPhenotype:0000529 name: cell_development_variant def: "Any variation in the progression of a cell from when it is first formed to when it becomes a mature structure when compared to control animals." [GO:0048468, WB:cab] subset: phenotype_slim_wb synonym: "cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000518 ! development_variant [Term] id: WBPhenotype:0000530 name: organ_system_development_variant def: "Any variation in the progression of an organismal system from its formation to the mature structure when compared to control animals." [GO:0048731, WB:cab] subset: phenotype_slim_wb synonym: "organ_system_development_abnormal" NARROW [] is_a: WBPhenotype:0000518 ! development_variant [Term] id: WBPhenotype:0000531 name: organism_development_variant def: "Any variation in the progression of a worm at any time from its fertilization to adulthood compared to control." [WB:cab] subset: phenotype_slim_wb synonym: "organism_development_abnormal" NARROW [] is_a: WBPhenotype:0000518 ! development_variant [Term] id: WBPhenotype:0000532 name: body_region_morphology_variant def: "Animals exhibit variations in the form, structure or composition of a discrete region of their anatomy compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_region_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000535 ! organism_morphology_variant [Term] id: WBPhenotype:0000533 name: cell_morphology_variant def: "Any variation in the form or composition of the basic structural and functional unit of all organisms compared to control. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GO:0005623, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000520 ! morphology_variant [Term] id: WBPhenotype:0000534 name: organ_system_morphology_variant def: "Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that comprise a specific organ system" [WB:WBPerson557] subset: phenotype_slim_wb synonym: "organ_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000520 ! morphology_variant [Term] id: WBPhenotype:0000535 name: organism_morphology_variant def: "Animals exhibit variations in the form, structure or composition of any part of their anatomy compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395] subset: phenotype_slim_wb synonym: "Bmd" BROAD three_letter_name [] synonym: "body morphology defects" RELATED [] synonym: "organism_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000520 ! morphology_variant [Term] id: WBPhenotype:0000536 name: cell_physiology_variant def: "Animals exhibit variations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for the cell to carry out its normal functions or be able to perceive and respond to stimuli, compared to control animals." [GO:0009987] subset: phenotype_slim_wb synonym: "cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000519 ! physiology_variant [Term] id: WBPhenotype:0000539 name: dorsal_nerve_cord_development_variant def: "Variations in the progression of the anatomical structures that consist of processes of ventral cord motor neurons that send commissures to the dorsal side, as well as processes of certain head and tail neurons, over time from initial formation to mature structure compared to control (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "dorsal_nerve_cord_development_abnormal" NARROW [] is_a: WBPhenotype:0000945 ! neuropil_development_variant [Term] id: WBPhenotype:0000540 name: muscle_arm_development_variant def: "Variations in the progression of the process extension from the muscle belly by which the muscle cells reach to the nerve cords to obtain innervation over time from initial formation to mature structure compared to control (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "muscle_arm_development_abnormal" NARROW [] is_a: WBPhenotype:0000087 ! body_wall_cell_development_variant [Term] id: WBPhenotype:0000541 name: cord_commissures_fail_to_reach_target def: "Axon tracts fail to complete the connection between nerve cords. In C. elegans, these tracts grow circumferentially around the animal, completing the connection between the ventral and dorsal nerve cords." [WB:WBPaper00001499, WB:WBPaper00028984, WB:WBPerson712] is_a: WBPhenotype:0000014 ! cord_commissures_variant [Term] id: WBPhenotype:0000542 name: fat def: "Animals exhibit an increased girth compared to a control animal of the same developmental stage." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001727 ! body_width_variant [Term] id: WBPhenotype:0000543 name: forward_kinker def: "Forward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves forward with uncharacteristic muscle spasms causing loss of smooth sinusoidal motion or body posture (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000002 ! kinker [Term] id: WBPhenotype:0000544 name: backward_kinker def: "Backward movement is often characterized by severe bending motions, more sharply angled and/or much deeper than stereotypical sinusoidal body bends of the control. Animal moves backward with uncharacteristic muscle spasms causing loss of smooth sinusoidal motion or body posture (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000002 ! kinker [Term] id: WBPhenotype:0000545 name: egg_retention def: "Eggs are retained in the uterus at a later stage when compared with control animals." [WB:cab] synonym: "late_eggs_laid" RELATED [] is_a: WBPhenotype:0000006 ! egg_laying_defective [Term] id: WBPhenotype:0000546 name: early_eggs_laid def: "Eggs are laid at an earlier stage of development when compared with control animals." [WB:cab] is_a: WBPhenotype:0000005 ! hyperactive_egg_laying [Term] id: WBPhenotype:0000547 name: starved def: "Animals exhibit morphological characteristics that are the outcome of nutrient deprivation. In C. elegans, starved worms have fewer refractile granules in intestinal cells, making them appear pale. Strongly starved mutants are small and thin, and tend to retain fewer eggs than control animals." [WB:WBPaper00001709, WB:WBPerson2021] synonym: "Eat" RELATED [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000548 name: muscle_dystrophy def: "Progressive degeneration of muscle." [WB:cab] is_a: WBPhenotype:0000611 ! muscle_system_physiology_variant [Term] id: WBPhenotype:0000549 name: head_muscle_dystrophy def: "Progressive degeneration of the head muscle." [WB:cab] is_a: WBPhenotype:0000548 ! muscle_dystrophy relationship: part_of WBPhenotype:0001002 ! head_muscle_behavior_variant [Term] id: WBPhenotype:0000550 name: body_muscle_dystrophy def: "Progressive degeneration of muscle along the body wall." [WB:cab] synonym: "body_wall_muscle_dystrophy" RELATED [] is_a: WBPhenotype:0000548 ! muscle_dystrophy relationship: part_of WBPhenotype:0000596 ! body_behavior_variant [Term] id: WBPhenotype:0000551 name: omega_turns_variant def: "Animals exhibit variations in the rate of sharp head to tail turns compared to control animals." [WB:WBPaper00000075, WB:WBPaper00006375, WB:WBPerson712] synonym: "omega_turns_abnormal" NARROW [] is_a: WBPhenotype:0001702 ! directionality_variant [Term] id: WBPhenotype:0000552 name: GABA_levels_variant def: "Animals exhibit variations in the amount of GABA compared to control animals at a defined stage." [WB:WBPerson2021, WB:WBPerson557] synonym: "GABA_levels_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0000553 name: muscle_ultrastructure_disorganized alt_id: WBPhenotype:0000714 def: "Animals exhibit structurally disorganized muscle fibers compared to control animals. In C. elegans, disorganized muscle fibers display a weak and abnormal birefringency pattern when examined using polarized optics" [WB:WBPerson557] comment: Disorganized muscle fibers display a weak and abnormal birefringency pattern when examined using polarized optics. synonym: "disorganized_muscle" EXACT [] synonym: "muscle_birefringence_abnormal" RELATED [] is_a: WBPhenotype:0000603 ! muscle_system_morphology_variant [Term] id: WBPhenotype:0000554 name: hypoosmotic_shock_hypersensitive def: "Any variation in the ability to adjust to a decline in ambient solute concentrations, thereby causing the body to swell and explode." [WB:WBPaper00000484, WB:WBPerson2021] is_a: WBPhenotype:0000041 ! osmotic_integrity_variant [Term] id: WBPhenotype:0000555 name: drug_adaptation_variant def: "Animals show variations in their decreased responsiveness after prolonged or repeated exposure to a drug compared to that in control." [WB:WBPerson2021, WB:WBPerson557] synonym: "drug_adaptation_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0000556 name: dopamine_adaptation_variant def: "Animals show variations in their decreased responsiveness after prolonged or repeated exposure to dopamine compared to that in control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dopamine_adaptation_abnormal" NARROW [] is_a: WBPhenotype:0000555 ! drug_adaptation_variant [Term] id: WBPhenotype:0000557 name: dopamine_adaptation_defective def: "Animals do not exhibit decreased responsiveness after prolonged or repeated exposure to dopamine." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000556 ! dopamine_adaptation_variant [Term] id: WBPhenotype:0000558 name: calcium_channel_modulator_response_variant def: "Animals exhibit variations in their response to specific calcium channel modulators compared to that observed in control animals." [WB:WBPerson557] synonym: "calcium_channel_modulator_response_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0000559 name: calcium_channel_modulator_hypersensitive def: "Animals respond to a calcium channel modulator at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive is_a: WBPhenotype:0000558 ! calcium_channel_modulator_response_variant [Term] id: WBPhenotype:0000560 name: calcium_channel_modulator_resistant def: "Animals fail to respond to the concentration of calcium channel modulators that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0000558 ! calcium_channel_modulator_response_variant [Term] id: WBPhenotype:0000561 name: head_levamisole_resistant def: "The heads of animals fail to respond to the concentration of levamisole that elicits a response in control animals. In C. elegans, heads contract at >10uM for intact animals and >1uM for cut animals" [WB:WBPaper00000484] synonym: "head_tetramisole_resistant" RELATED [] is_a: WBPhenotype:0000421 ! levamisole_resistant [Term] id: WBPhenotype:0000562 name: body_levamisole_resistant def: "The bodies of animals fail to respond to the concentration of levamisole that elicits a response in control animals." [WB:WBPaper00000484] synonym: "body_tetramisole_resistant" RELATED [] is_a: WBPhenotype:0000421 ! levamisole_resistant [Term] id: WBPhenotype:0000563 name: shrinker def: "The whole body undergoes longitudinal shortening in response to head touch or tail touch(Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000564 name: echo_defecation_cycle def: "Muscle contractions that make up the defecation motor program are repeated before the onset of the next cycle unlike in control animals." [WB:WBPaper00002305, WB:WBPaper00003765, WB:WBPerson712] is_a: WBPhenotype:0000207 ! defecation_cycle_variant [Term] id: WBPhenotype:0000565 name: coiler def: "The body of an animal assumes a coil-like shape when it attempts to move." [WB:WBPerson363] synonym: "curler" RELATED [] is_a: WBPhenotype:0000001 ! body_posture_variant is_a: WBPhenotype:0004017 ! locomotor_coordination_variant [Term] id: WBPhenotype:0000566 name: ventral_coiler def: "A coiling body that bends ventrally." [WB:WBPerson363] synonym: "ventral_curler" RELATED [] is_a: WBPhenotype:0000565 ! coiler [Term] id: WBPhenotype:0000567 name: dorsal_coiler def: "A coiling body that bends dorsally." [WB:WBperson363] synonym: "dorsal_curler" RELATED [] is_a: WBPhenotype:0000565 ! coiler [Term] id: WBPhenotype:0000568 name: axon_ultrastructure_variant def: "Animals display variations in the structure or organization of the components of the axon, compared to that observed in control animals." [WB:WBPaper00001499, WB:WBPerson712] synonym: "axon_ultrastructure_abnormal" NARROW [] is_a: WBPhenotype:0000180 ! axon_morphology_variant [Term] id: WBPhenotype:0000569 name: axon_varicosities def: "Animals display markedly swollen areas along their axons, which are larger than synaptic varicosities in control animals." [WB:WBPaper00001499, WB:WBPaper00024595, WB:WBPerson712] is_a: WBPhenotype:0000568 ! axon_ultrastructure_variant [Term] id: WBPhenotype:0000570 name: axon_cisternae def: "Axons of animals contain flattened membrane-bound compartments. In C. elegans, these cisternae-like structures are typically absent." [WB:WBPaper00001499, WB:WBPaper00024595, WB:WBPerson712] is_a: WBPhenotype:0000568 ! axon_ultrastructure_variant [Term] id: WBPhenotype:0000571 name: axon_vesicle_variant def: "Axons of animals exhibit variations in the gross structure or organization of its spherical, membrane-bound, fluid-filled organelles, compared to that observed in control animals." [WB:WBPaper00001499, WB:WBPerson712] synonym: "abnormal_axon_vesicle" NARROW [] is_a: WBPhenotype:0000568 ! axon_ultrastructure_variant [Term] id: WBPhenotype:0000572 name: neuronal_outgrowth_variant def: "Any variation in the processes that govern the extension of neuronal projections." [WB:WBPerson2021] synonym: "neuronal_outgrowth_abnormal" NARROW [] is_a: WBPhenotype:0000816 ! neuron_development_variant [Term] id: WBPhenotype:0000573 name: neuronal_branching_variant synonym: "neuronal_branching_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000574 name: excretory_canal_short def: "The structure made by the processes of the excretory canal cell is reduced in size compared to control. In C. elegans this is an H-shaped structure which extends almost the full length of the body on both sides of the animal, generally in contact with the lateral hypodermis and the pseudocoelom (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] relationship: part_of WBPhenotype:0000704 ! excretory_canal_morphology_variant [Term] id: WBPhenotype:0000575 name: organ_system_physiology_variant def: "Animals exhibit variations in a physical or chemical process required for organs or tissues to carry out their normal functions or for their ability to perceive and respond to stimuli compared to control." [GO:0003008] subset: phenotype_slim_wb synonym: "organ_system_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000519 ! physiology_variant [Term] id: WBPhenotype:0000576 name: organism_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the organism to carry out its normal function or be able to perceive and respond to stimuli." [WB:WBPerson712] subset: phenotype_slim_wb synonym: "organism_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000519 ! physiology_variant [Term] id: WBPhenotype:0000577 name: organism_homeostasis_metabolism_variant def: "Variations in the chemical reactions and pathways involved in the maintenance of an internal equilibrium at the level of the organism compared to control." [GO:0048871, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "organism_homeostasis_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism_physiology_variant [Term] id: WBPhenotype:0000578 name: body_axis_development_variant def: "Variations in the progression of a discrete axis of an animal's anatomy over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_axis_development_abnormal" NARROW [] is_a: WBPhenotype:0000528 ! body_region_development_variant [Term] id: WBPhenotype:0000579 name: organism_segment_development_variant def: "Variations in the progression of the overall structure or appearance of any anterior/posterior section of an animal's anatomy over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism_segment_development_abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism_development_variant [Term] id: WBPhenotype:0000580 name: organism_segment_behavior_variant def: "Variations in the specific actions or reactions of a certain body region of an animal in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism_segment_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000522 ! organism_region_behavior_variant [Term] id: WBPhenotype:0000581 name: body_axis_morphology_variant def: "Animals exhibit variations in the form, structure or composition of a discrete axis (dorsal/ventral/anterior/posterior/transverse) of their anatomy, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_axis_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000532 ! body_region_morphology_variant [Term] id: WBPhenotype:0000582 name: organism_segment_morphology_variant def: "Animals exhibit variations in the form, structure or composition of any anterior/posterior section of their anatomy compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "organism_segment_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000535 ! organism_morphology_variant [Term] id: WBPhenotype:0000583 name: dumpy def: "Worms are shorter and stouter than control animals at the same developmental stage." [WB:cab, WB:cgc31, WB:WBPaper00004402, WB:WBPaper00004403, WB:WBPaper00004651, WB:WBPaper00005654, WB:WBPaper00006395, WB:WBPaper00024497] synonym: "Dpy" BROAD three_letter_name [] is_a: WBPhenotype:0001726 ! body_length_variant is_a: WBPhenotype:0001727 ! body_width_variant [Term] id: WBPhenotype:0000584 name: synaptic_transmission_variant alt_id: WBPhenotype:0000537 alt_id: WBPhenotype:0000538 def: "Any variation in the process of communication across a synapse between a neuron and a target cell (neuron, muscle, or secretory cell) compared to control animals." [GO:0007268, WB:cab] synonym: "synaptic_input_abnormal" NARROW [] synonym: "synaptic_input_variant" EXACT [] synonym: "synaptic_output_abnormal" NARROW [] synonym: "synaptic_output_variant" EXACT [] synonym: "synaptic_transmission_abnormal" NARROW [] is_a: WBPhenotype:0000612 ! nervous_system_physiology_variant is_a: WBPhenotype:0000816 ! neuron_development_variant [Term] id: WBPhenotype:0000585 name: cell_homeostasis_metabolism_variant def: "Variations in the chemical reactions and pathways involved in the maintenance of an internal equilibrium at the level of the cell compared to control." [GO:0019725, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell_homeostasis_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000586 name: bleach_hypersensitive def: "Animals respond to bleach at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000524 ! bleach_response_variant [Term] id: WBPhenotype:0000587 name: lectin_staining_variant synonym: "lectin_staining_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000588 name: no_male_variantity_scored synonym: "no_male_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000589 name: no_hermaphrodite_variantity_scored synonym: "no_hermaphrodite_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000590 name: cell_corpse_number_variant def: "Animals exhibit a decreased rate programmed cell death pathway leading to the destruction of the cell, viewable by its remnants in its terminally dismanteled form , cell corpse, compared to that observed for control cells." [WB:WBPerson712] synonym: "cell_corpse_number_abnormal" NARROW [] is_a: WBPhenotype:0000730 ! apoptosis_variant [Term] id: WBPhenotype:0000591 name: metal_response_variant def: "Animals exhibit variations in their response to a specific metal compared to that observed in control animals." [WB:WBPerson557] synonym: "metal_response_abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0000592 name: copper_response_variant def: "Animals exhibit variations in their response to copper compared to that observed in control animals." [WB:WBPerson557] synonym: "copper_response_abnormal" NARROW [] is_a: WBPhenotype:0000591 ! metal_response_variant [Term] id: WBPhenotype:0000593 name: copper_hypersensitive def: "Animals respond to copper at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000592 ! copper_response_variant [Term] id: WBPhenotype:0000594 name: cell_migration_variant def: "Any variation in the orderly movement of a cell from one site to another." [GO:0016477, WB:cab] subset: phenotype_slim_wb synonym: "cell_migration_abnormal" NARROW [] synonym: "Mig" BROAD three_letter_name [] synonym: "migration_of_cells_abnormal" RELATED [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000595 name: head_behavior_variant def: "Variations in the specific actions or reactions of the head in response to external or internal stimuli compared to that observed in control animals." [WB:cab, WB:WBPerson2021, WB:WBPerson557] synonym: "head_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000580 ! organism_segment_behavior_variant [Term] id: WBPhenotype:0000596 name: body_behavior_variant def: "Activity characteristic of the body is altered compared to control." [WB:cab] synonym: "body_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000580 ! organism_segment_behavior_variant [Term] id: WBPhenotype:0000597 name: tail_behavior_variant def: "Variations in the specific actions or reactions of the tail in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "tail_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000580 ! organism_segment_behavior_variant [Term] id: WBPhenotype:0000598 name: alimentary_system_morphology_variant def: "Variations in the form, structure or composition of the series of related tissues lying within the body cavity and devoted to feeding and digestion compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "alimentary_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ_system_morphology_variant [Term] id: WBPhenotype:0000599 name: coelomic_system_morphology_variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the coelomic system, compared to control. The coelom is the fluid compartment that is in contact with internal organ" [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "coelomic_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ_system_morphology_variant [Term] id: WBPhenotype:0000600 name: epithelial_system_morphology_variant def: "Variations in the form, composition or structure of the epithelial system that serves to protect the organism from the external environment compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "epithelial_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ_system_morphology_variant [Term] id: WBPhenotype:0000601 name: excretory_secretory_system_morphology_variant alt_id: WBPhenotype:0000602 def: "Variations in the form, structure or composition of related tissues that allow the animal to secrete saline fluid and maintain a proper salt balance compared to control. In C. elegans, four cell types (1 pore cell, 1 duct cell, 1 canal cell and a fused pair of gland cells) make up the excretory system (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "excretory_secretory_system_morphology_abnormal" NARROW [] synonym: "excretory_system_morphology_abnormal" NARROW [] synonym: "excretory_system_morphology_variant" EXACT [] is_a: WBPhenotype:0000534 ! organ_system_morphology_variant [Term] id: WBPhenotype:0000603 name: muscle_system_morphology_variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the muscle system, compared to control. The muscle system consists of tissues made up of various elongated cells that are specialized to contract and produce movement and mechanical work." [GO:0007517, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "muscle_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ_system_morphology_variant [Term] id: WBPhenotype:0000604 name: nervous_system_morphology_variant def: "Animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals." [WB:WBPerson712] comment: WB:WBbt:0005735 subset: phenotype_slim_wb synonym: "nervous_system_morphology_abnormal" NARROW [] synonym: "neuroanatomical_defective" RELATED [] is_a: WBPhenotype:0000534 ! organ_system_morphology_variant [Term] id: WBPhenotype:0000605 name: reproductive_system_morphology_variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "reproductive_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000534 ! organ_system_morphology_variant [Term] id: WBPhenotype:0000606 name: alimentary_system_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the coelomic system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "alimentary_system_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ_system_physiology_variant [Term] id: WBPhenotype:0000607 name: coelomic_system_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the coelomic system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "coelomic_system_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ_system_physiology_variant [Term] id: WBPhenotype:0000608 name: epithelial_system_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the epithelial system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "epithelial_system_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ_system_physiology_variant [Term] id: WBPhenotype:0000609 name: excretory_secretory_system_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the excretory/secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "excretory_secretory_system_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ_system_physiology_variant [Term] id: WBPhenotype:0000610 name: excretory_system_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the secretory system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "excretory_system_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ_system_physiology_variant [Term] id: WBPhenotype:0000611 name: muscle_system_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "muscle_system_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ_system_physiology_variant [Term] id: WBPhenotype:0000612 name: nervous_system_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the nervous system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "nervous_system_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ_system_physiology_variant [Term] id: WBPhenotype:0000613 name: reproductive_system_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the reproductive system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0003008, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "reproductive_system_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000575 ! organ_system_physiology_variant [Term] id: WBPhenotype:0000614 name: GLR_development_variant def: "Any variation in the progression of the GLR accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "GLR_development_abnormal" NARROW [] is_a: WBPhenotype:0000942 ! accessory_cell_development_variant [Term] id: WBPhenotype:0000615 name: cilia_morphology_variant def: "Animals exhibit variations in the structure or organization of the microtubule-based dendritic projections extending from the cell body, compared to that observed in control animals. In C. elegans, cilia are classified as channel cilia or wing cilia depending on their placement within the sensillum. Channel cilia of control animals are cylindrical, extend into the sensillum pore and are exposed to the outside. Wing cilia of control animals vary in shape, are embedded in the sensillum sheath cell and are not typically refractory to dyes indicating exposure to the outside." [WB:WBPaper00000214, WB:WBPaper00000932, WB:WBPerson712] synonym: "cilia_morphology_abnormal" NARROW [] synonym: "defective_dye_filling_of_cilia" RELATED [] is_a: WBPhenotype:0001526 ! ciliated_neuron_morphology_variant [Term] id: WBPhenotype:0000616 name: synapse_morphology_variant def: "Animals display variations in the appearance of the subcellular junctional structure composed of a presynaptic terminal directly opposite the post-synaptic target and separated by a synaptic cleft." [GO:0045202, WB:WBPaper00027305, WB:WBPerson712] synonym: "synapse_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000604 ! nervous_system_morphology_variant [Term] id: WBPhenotype:0000617 name: alimentary_system_development_variant def: "Any variation in the progression of the alimentary system over time, from its formation to its mature state compared to control. The alimentary system includes all the body structures involved in preparing food for absorption into the body and excretion of waste products." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "alimentary_system_development_abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ_system_development_variant [Term] id: WBPhenotype:0000618 name: coelomic_system_development_variant def: "Any variation in the progression of the coelomic system over time, from its formation to its mature state compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "coelomic_system_development_abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ_system_development_variant [Term] id: WBPhenotype:0000619 name: epithelial_system_development_variant def: "Any variation in the progression of the epithelial system over time, from its formation to its mature state compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "epithelial_system_development_abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ_system_development_variant [Term] id: WBPhenotype:0000620 name: excretory_secretory_system_development_variant def: "Any variation in the progression of the excretory secretory system over time, from its formation to its mature state compared to control. The excretory secretory system consists of the excretory system and its associated glands." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "excretory_secretory_system_development_abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ_system_development_variant [Term] id: WBPhenotype:0000621 name: excretory_system_development_variant def: "Variations in the progression of the excretory system over time, from its formation to the mature structure. The excretory system is required for the elimination of metabolic waste. In C. elegans, the excretory system is comprised of the excretory cell, excretory duct cell and excretory socket cell." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "excretory_system_development_abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ_system_development_variant relationship: part_of WBPhenotype:0000620 ! excretory_secretory_system_development_variant [Term] id: WBPhenotype:0000622 name: muscle_system_development_variant def: "Any variation in the progression of the muscle system over time, from its formation to its mature state compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "muscle_system_development_abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ_system_development_variant [Term] id: WBPhenotype:0000623 name: nervous_system_development_variant def: "Any variation in the progression of nervous tissue over time, from its formation to its mature state compared to control." [GO:0007399, WB:cab] subset: phenotype_slim_wb synonym: "nervous_system_development_abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ_system_development_variant [Term] id: WBPhenotype:0000624 name: reproductive_system_development_variant def: "Any variation in the progression of the reproductive system over time, from its formation to its mature state compared to control." [WB:WBPerson2021] subset: phenotype_slim_wb synonym: "reproductive_defect" RELATED [] synonym: "reproductive_system_development_abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ_system_development_variant [Term] id: WBPhenotype:0000625 name: synaptogenesis_variant def: "Any variation in the biosynthesis of a synapse compared to control." [GO:0007416, WB:cab] synonym: "synaptogenesis_abnormal" NARROW [] is_a: WBPhenotype:0000623 ! nervous_system_development_variant [Term] id: WBPhenotype:0000626 name: habituation_variant def: "Any variation in the decrease in a behavioral response to a repeated stimulus compared to control." [GO:0046959, WB:cab] subset: phenotype_slim_wb synonym: "habituation_abnormal" NARROW [] synonym: "non_associative_learning" RELATED [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000627 name: anesthetic_response_variant def: "Animals exhibit variations in their response to a specific anesthetic compared to that observed in control animals." [WB:WBPerson557] synonym: "anesthetic_response_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0000628 name: spindle_assembly_defective_early_emb def: "Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. " [GO:0051225, WB:cab, WB:cgc7141, WB:WBPerson2021] comment: Possible XP synonym: "Emb" BROAD three_letter_name [] synonym: "spindle_assembly_abnormal" NARROW [] is_a: WBPhenotype:0001102 ! mitotic_spindle_defective_early_emb [Term] id: WBPhenotype:0000629 name: ectopic_neurite_outgrowth def: "Any variation that causes an increase in the frequency of neurite (axon or dendrite) outgrowth. As a result, an excess number of neuronal projections are generated." [WB:WBPerson2021] is_a: WBPhenotype:0000572 ! neuronal_outgrowth_variant [Term] id: WBPhenotype:0000630 name: quinine_chemotaxis_defective def: "Failure to execute the characteristic response to quinine, as defined by control animals. In C. elegans, quinine is typically repellent." [WB:WBPaper00006481] is_a: WBPhenotype:0001449 ! aqueous_negative_chemotaxis_defective is_a: WBPhenotype:0001454 ! quinine_chemotaxis_variant [Term] id: WBPhenotype:0000631 name: drug_response_variant def: "Any variation in the characteristic response(s) to drug(s) as defined by control animals." [WB:cab] synonym: "drug_response_abnormal" RELATED [] synonym: "drug_response_abnormal" NARROW [] is_a: WBPhenotype:0000523 ! chemical_response_variant [Term] id: WBPhenotype:0000632 name: axon_fasciculation_variant def: "The ability of axons to converge and form a bundle of nerve fibres (fascicle) is compromised." [GO:0007413, WB:WBPerson2021] synonym: "axon_fasciculation_abnormal" NARROW [] is_a: WBPhenotype:0000880 ! axon_development_variant [Term] id: WBPhenotype:0000633 name: axon_branching_variant def: "Animals display variations in the number or pattern of axonal tracts stemming from the neuron cell body, compared to that observed in control animals." [GO:0048755, WB:WBPaper00027335, WB:WBPaper00027711, WB:WBPerson712] synonym: "axon_branching_abnormal" NARROW [] is_a: WBPhenotype:0000180 ! axon_morphology_variant is_a: WBPhenotype:0001224 ! axon_outgrowth_variant [Term] id: WBPhenotype:0000634 name: pharyngeal_pumping_variant def: "Any variation in the contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes compared to control." [GO:0043050, WB:cab] subset: phenotype_slim_wb synonym: "pharyngeal_pumping_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000635 name: positive_chemotaxis_variant def: "Any variation in the directed movement of an animal in response to chemical attractants as defined by control animals. " [GO:0050918, WB:cab, WB:cgc122, WB:cgc387] synonym: "positive_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001434 ! chemotaxis_variant [Term] id: WBPhenotype:0000636 name: neuron_degeneration_variant def: "Any variation in the ability of neurons to undergo a dramatic decrease in cell volume, collapse of the vacuoles and processes, and complete disintegration of the plasma membrane and most organelles under conditions that ellicit this response in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuron_degeneration_abnormal" NARROW [] relationship: part_of WBPhenotype:0000612 ! nervous_system_physiology_variant [Term] id: WBPhenotype:0000637 name: dauer_formation_variant def: "Characteristic entry into the dauer stage is altered compared to control animals." [WB:cab] synonym: "Daf" BROAD three_letter_name [] synonym: "dauer_formation_abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer_arrest_variant is_a: WBPhenotype:0000308 ! dauer_development_variant [Term] id: WBPhenotype:0000638 name: molt_defect def: "Animals exhibit defects in the process of periodic shedding, of part or all of its cuticle, during cuticle replacement that punctuates each larval stage." [GO:0018996, WB:WBPerson712] synonym: "Mlt" BROAD three_letter_name [] synonym: "Mult" BROAD [] is_a: WBPhenotype:0000750 ! larval_development_variant [Term] id: WBPhenotype:0000639 name: temperature_induced_dauer_formation_variant def: "Animals exhibit variations in the entry into the dauer stage when exposed to temperatures that induce dauer formation in control animals. In C. elegans, many Daf-c animals enter dauer at 25C, whereas Hid animals enter dauer at 27C." [WB:WBPaper00006103, WB:WBPerson2021, WB:WBPerson557, WB:WBPerson712] synonym: "Hid" RELATED [] synonym: "temperature_induced_dauer_formation_abnormal" NARROW [] is_a: WBPhenotype:0000146 ! organism_temperature_response_variant is_a: WBPhenotype:0001539 ! dauer_induction_variant [Term] id: WBPhenotype:0000640 name: egg_laying_variant def: " Animals exhibit variations in the stage of eggs laid, egg laying cycle, or egg laying in response to stimuli compared to control." [pmid:11813735, pmid:9697864, WB:cab] comment: visual inspection. subset: phenotype_slim_wb synonym: "egg_laying_abnormal" NARROW [] synonym: "Egl" BROAD three_letter_name [] synonym: "oviposition_abnormal" RELATED [GO:0018991] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000641 name: activity_level_variant def: "Any variation in the degree of movement compared to control animals." [WB:cab] synonym: "activity_level_abnormal" NARROW [] is_a: WBPhenotype:0000643 ! locomotion_variant [Term] id: WBPhenotype:0000642 name: hyperactive def: "Worms move forward or backward with an increased rate of body bends per minute compared to control animals." [WB:cab, WB:WBPaper00004402, WB:WBPaper00006395] synonym: "Hya" BROAD three_letter_name [] is_a: WBPhenotype:0000641 ! activity_level_variant [Term] id: WBPhenotype:0000643 name: locomotion_variant def: "Animals exhibit deviations in self-propelled movement on a solid medium compared to control animals." [GO:0040011, WB:cab, WB:WBPaper00024949, WB:WBPerson712] subset: phenotype_slim_wb synonym: "locomotion_abnormal" NARROW [] synonym: "movement_defect" RELATED [] synonym: "Unc" BROAD three_letter_name [] synonym: "uncoordinated" RELATED [] is_a: WBPhenotype:0001206 ! movement_variant [Term] id: WBPhenotype:0000644 name: paralyzed def: "Animals do not move and are not responsive to external mechanical stimulation." [WB:cab] subset: phenotype_slim_wb synonym: "Prl" BROAD three_letter_name [] synonym: "Prz" RELATED [] is_a: WBPhenotype:0001213 ! locomotion_reduced [Term] id: WBPhenotype:0000645 name: roller def: "The body of the animal rotates around its long axis as the animal moves, causing the animal to move in a circular pattern. In liquid media, wave propogation is helical rather than planar." [WB:cab, WB:cgc31] synonym: "Rol" BROAD three_letter_name [] is_a: WBPhenotype:0004017 ! locomotor_coordination_variant [Term] id: WBPhenotype:0000646 name: sluggish def: "Animals move more slowly compared with control animals." [WB:cab] synonym: "lethargic" RELATED [] synonym: "slow" RELATED [] synonym: "Slu" BROAD three_letter_name [] is_a: WBPhenotype:0001213 ! locomotion_reduced [Term] id: WBPhenotype:0000647 name: copulation_variant def: "Animals exhibit variations in any processes that lead to the successful transfer of sperm from one organism to another." [GO:0007620, WB:cab] subset: phenotype_slim_wb synonym: "Cod" BROAD three_letter_name [] synonym: "copulation_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000648 name: male_mating_variant def: "Any varaition in the specific actions or reactions of the male that are associated with reproduction compared to control." [GO:0060179, WB:cab] synonym: "male_mating_abnormal" NARROW [] is_a: WBPhenotype:0000647 ! copulation_variant is_a: WBPhenotype:0000888 ! male_behavior_variant [Term] id: WBPhenotype:0000649 name: vulva_location_variant def: "Any variation in the male's ability to locate his partner's vulva when backing along the ventral side of the partner during mating compared to control. In C. elegans the male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [GO:0034608, WB:WBPerson2021, WB:WBPerson557] synonym: "Lov" RELATED [] synonym: "vulva_location_abnormal" NARROW [] is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_variant [Term] id: WBPhenotype:0000650 name: defecation_variant def: "Animals exhibit variations in the processes involved in eliminating gut contents compared to control animals. In C. elegans the sequence of events during defecation includes posterior body contraction (pBoc), relaxation, anterior body contraction (aBoc), expulsion of gut contents by enteric muscle contraction (Emc) and opening of anus (Exp), and intercycle period(Wormatlas). " [GO:0030421, WB:cab, WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "defecation_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000651 name: constipated def: "Animals exhibit delayed or infrequent passage and/or expulsion of fecal matter." [WB:WBPerson2021] synonym: "Con" BROAD three_letter_name [] is_a: WBPhenotype:0000650 ! defecation_variant [Term] id: WBPhenotype:0000652 name: sensory_system_variant def: "Variations in the progression of a set of interacting or interdependent entities forming the sensory system over time from an initial condition to a later condition compared to control animals. The sensory system is involved in the perception of a stimuli, its conversion into a signal and the recognition and characterization of the resulting signal." [WB:WBPerson2021, WB:WBPerson557] synonym: "sensory_system_abnormal" NARROW [] relationship: part_of WBPhenotype:0000612 ! nervous_system_physiology_variant [Term] id: WBPhenotype:0000653 name: mechanosensory_system_variant def: "Variations in the progression of a set of interacting or interdependent entities forming the mechanosensory system over time from an initial condition to a later condition compared to control animals. The mechanosensory system is involved in the perception of a mechanical stimuli, its conversion into a signal and the recognition and characterization of the resulting signal." [WB:WBPerson2021, WB:WBPerson557] synonym: "mechanosensory_system_abnormal" NARROW [] relationship: part_of WBPhenotype:0000652 ! sensory_system_variant [Term] id: WBPhenotype:0000654 name: synaptic_vesicle_exocytosis_variant def: "Animals exhibit variations in the fusion of intracellular neurotransmitter-filled membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell compared to control." [GO:0016079, WB:WBPerson712] synonym: "synaptic_vesicle_exocytosis_abnormal" NARROW [] is_a: WBPhenotype:0000728 ! exocytosis_variant is_a: WBPhenotype:0001684 ! synaptic_vesicle_homeostasis_variant [Term] id: WBPhenotype:0000655 name: GABA_synaptic_transmission_variant def: "Animals exhibit variations in the process of GABA neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control." [GO:0007268, WB:WBPerson712] synonym: "GABA_synaptic_transmission_abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic_transmission_variant [Term] id: WBPhenotype:0000656 name: acetylcholine_synaptic_transmission_variant def: "Animals exhibit variations in the process of acetylcholine neurotransmitter-based communication from a neuron to a target cell across a synapse compared to control" [GO:0007268, WB:WBPerson712] synonym: "acetylcholine_synaptic_transmission_abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic_transmission_variant [Term] id: WBPhenotype:0000657 name: neuronal_synaptic_transmission_variant def: "Any variation in the process of information transfer between two neurons; usually in reference to chemical synapses, but can also be used to refer to electrical synapses compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuronal_synaptic_transmission_abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic_transmission_variant [Term] id: WBPhenotype:0000658 name: neuromuscular_synaptic_transmission_variant def: "Any variation in the process of communication across a synapse between a neuron and a target muscle cell compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuromuscular_synaptic_transmission_abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic_transmission_variant [Term] id: WBPhenotype:0000659 name: feeding_behavior_variant def: "Behavior associated with the intake of food is altered compared to control." [GO:0007631, WB:WBPerson557] subset: phenotype_slim_wb synonym: "Eat" BROAD three_letter_name [] synonym: "feeding_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000660 name: social_feeding_increased def: "Worms are found in clumps and/or crowded at the border of the bacterial lawn more frequently than control animals. This behavior is not due to mobility defects." [WB:WBPerson712] synonym: "bordering_increased" RELATED [] synonym: "social_behavior_enhanced" RELATED [] is_a: WBPhenotype:0000659 ! feeding_behavior_variant is_a: WBPhenotype:0001291 ! social_behavior_variant [Term] id: WBPhenotype:0000661 name: solitary_feeding_increased def: "Animals disperse across a bacterial lawn and feed alone. When food is limiting, they can aggregate into swarms or clumps, but disperse once again when food is absent." [WB:WBPaper00003187, WB:WBPaper00032342, WB:WBPerson712] synonym: "solitary_behavior_enhanced" RELATED [] synonym: "solitary_forager_on_food" RELATED [] is_a: WBPhenotype:0000659 ! feeding_behavior_variant is_a: WBPhenotype:0001291 ! social_behavior_variant [Term] id: WBPhenotype:0000662 name: foraging_behavior_variant def: "Animals exhibit variations in roaming or dwelling activity on food compared to control. Roaming is defined as moving in a high-speed forward direction with brief backward movement, often traversing wide regions. Dwelling is defined as low-speed/high turning movement restricted to a confined region." [WB:WBPaper00005621, WB:WBPaper00031455, WB:WBPerson712] subset: phenotype_slim_wb synonym: "foraging_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000663 name: osmotic_avoidance_variant def: "Animals exhibit variations in the avoidance response to solutions of a particular osmotic strength compared to control. In C. elegans, animals typically avoid solutions of high osmotic strength." [WB:WBPerson2021] synonym: "osmotic_avoidance_abnormal" NARROW [] is_a: WBPhenotype:0000481 ! negative_chemotaxis_variant [Term] id: WBPhenotype:0000664 name: exaggerated_body_bends alt_id: WBPhenotype:0004021 def: "The maximum ventral and dorsal flex of the animal is greater than that observed for control animals." [WB:WBPerson712] synonym: "exaggerated_body_bends" EXACT [] synonym: "loopy" RELATED [] synonym: "Lpy " RELATED [] is_a: WBPhenotype:0001703 ! body_bend_variant [Term] id: WBPhenotype:0000665 name: connection_of_gonad_variant def: "Any variation that disrupts the connectivity between the somatic gonad and the adjoining tissues compared to control. In C. elegans this connnection is between the somatic gonad and the vulva in hermaphrodites and between the somatic gonad and proctodeum in males." [WB:WBPerson2021, WB:WBPerson557] synonym: "Cog" RELATED [] synonym: "connection_of_gonad_abnormal" NARROW [] relationship: part_of WBPhenotype:0000605 ! reproductive_system_morphology_variant [Term] id: WBPhenotype:0000666 name: ovulation_variant def: "Any variation that disrupts the release of a\nmature oocyte into the spermatheca (for subsequent fertilization), compared to control " [GO:0030728, WB:WBPaper00003017, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "ovulation_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000667 name: gonad_displaced def: "The specialized tissue of the reproductive tract that produces gamete is shifted from its customary place as defined by control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_variant [Term] id: WBPhenotype:0000668 name: endomitotic_oocytes def: "Any variation that results in the presence of mature oocytes with distended polyploid nuclei. In C. elegans, such oocytes mature and exit diakinesis, but are often not properly ovulated or fertilized." [WB:kmva] synonym: "arrest_in_meiosis_I" RELATED [] synonym: "Emo" BROAD three_letter_name [] is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_variant [Term] id: WBPhenotype:0000669 name: sex_muscle_development_variant def: "Variations in the progression of the muscles of the adult reproductive system over time form their initial formation to their mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "sex_muscle_development_abnormal" NARROW [] is_a: WBPhenotype:0000860 ! nonstriated_muscle_development_variant relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_variant [Term] id: WBPhenotype:0000670 name: spermatogenesis_variant alt_id: WBPhenotype:0000895 def: "Any variation in the processes that influence the generation and maturation of spermatozoa (motile sperm) compared to control." [GO:0007283, WB:WBPaper00027300, WB:WBPerson2021] synonym: "spermatocyte_germ_cell_differentiation_abnormal" EXACT [] synonym: "spermatogenesis_abnormal" NARROW [] is_a: WBPhenotype:0000894 ! germ_cell_differentiation_variant [Term] id: WBPhenotype:0000671 name: resistant_to_copper def: "Animals fail to respond to the concentration of copper that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to copper to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000592 ! copper_response_variant [Term] id: WBPhenotype:0000672 name: presynaptic_vesicle_cluster_localization_variant def: "Animals display variations in the distribution of transmitter-filled vesicles in relation to the electron-dense membrane specialization of the neuron,compared to that observed in control animals." [WB:WBPaper00027305, WB:WBPaper00027711, WB:WBPerson712] synonym: "presynaptic_vesicle_cluster_localization_abnormal" NARROW [] synonym: "synaptic_vesicle_cluster_localization_abnormal" RELATED [] is_a: WBPhenotype:0000102 ! presynaptic_vesicle_cluster_variant [Term] id: WBPhenotype:0000673 name: brood_size_variant def: "The number of offspring produced is altered compared to that of control animals." [WB:WBPerson557] synonym: "brood_size_abnormal" NARROW [] is_a: WBPhenotype:0000806 ! hermaphrodite_fertility_variant [Term] id: WBPhenotype:0000674 name: slow_development def: "The developmental progression of an animal, from its formation to its mature structure occurs over a longer time period compared to control. " [WB:WBPerson2021, WB:WBPerson557] synonym: "retarded_development" RELATED [] is_a: WBPhenotype:0000043 ! general_pace_of_development_variant [Term] id: WBPhenotype:0000675 name: zygotic_lethal def: "Animals die after fusion of gametes without dividing." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" RELATED [] is_a: WBPhenotype:0000213 ! zygotic_development_variant [Term] id: WBPhenotype:0000676 name: growth_rate_variant def: "The increase in size or mass of an organism over time during the lifespan of the organism or over any developmental stage(s) is not similar to that observed for control animals." [GO:0040007, WB:WBPerson712] synonym: "growth_rate_abnormal" NARROW [] is_a: WBPhenotype:0000030 ! growth_variant [Term] id: WBPhenotype:0000677 name: chemosensation_defective def: "Animals fail to receive, process or recognize a sensory chemical stimulus in the same manner as control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001050 ! chemosensation_variant [Term] id: WBPhenotype:0000678 name: no_copper_sensitivity is_obsolete: true [Term] id: WBPhenotype:0000679 name: transgene_subcellular_localization_variant def: "Any variation in the subcellular localization of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] synonym: "transgene_subcellular_localization_abnormal" NARROW [] is_a: WBPhenotype:0000961 ! pattern_of_transgene_expression_variant [Term] id: WBPhenotype:0000680 name: aldicarb_response_variant def: "Animals exhibit variations in their response to aldicarb compared to that observed in control animals." [WB:WBPerson557] synonym: "aldicarb_response_abnormal" NARROW [] is_a: WBPhenotype:0001290 ! acetylcholinesterase_inhibitor_response_variant [Term] id: WBPhenotype:0000681 name: DMPP_response_variant def: "Animals exhibit variations in their response to DMPP compared to that observed in control animals." [WB:WBPerson557] synonym: "DMPP_response_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0000682 name: feminization_of_germline def: "Hermaphrodites are transformed into fertile females; In C. elegans, XO fog animals are somatically male but produce oocytes instead of, or in addition to, sperm." [pmid:3396865, WB:cab] synonym: "feminization_of_germ line" EXACT [] synonym: "Fog" BROAD three_letter_name [] is_a: WBPhenotype:0000687 ! feminization_of_XX_and_XO_animals is_a: WBPhenotype:0000812 ! germ_cell_development_variant [Term] id: WBPhenotype:0000683 name: masculinization_of_germline def: " The germ line is sexually transformed from hermaphrodite to male. In C. elegans, XX mog animals are somatically hermaphrodite, but germ cells that normally would become oocytes are transformed into sperm." [WB:WBPaper00001710, WB:WBPerson2021] synonym: "masculinization of germ line" EXACT [] synonym: "Mog" BROAD three_letter_name [] is_a: WBPhenotype:0000812 ! germ_cell_development_variant is_a: WBPhenotype:0001572 ! masculinized [Term] id: WBPhenotype:0000684 name: fewer_germ_cells def: "Germ cell populations are reduced compared to control animals." [WB:cab, WB:WBPerson2021] synonym: "Fgc" BROAD three_letter_name [] is_a: WBPhenotype:0000823 ! germline_proliferation_variant [Term] id: WBPhenotype:0000685 name: larval_growth_slow def: "Any variation that causes a reduction in growth rate during larval stages compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001016 ! larval_growth_variant [Term] id: WBPhenotype:0000686 name: organism_ionizing_radiation_response_variant def: "Animals exhibit variations in their response ionizing radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "organism_ionizing_radiation_response_abnormal" NARROW [] synonym: "reactive_oxygen_species_abnormal" BROAD [WB:WBPaper00031296] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000687 name: feminization_of_XX_and_XO_animals def: "Both hermaphrodites and males develop into fertile females." [WB:cab] synonym: "Fem" BROAD three_letter_name [] is_a: WBPhenotype:0000049 ! postembryonic_development_variant is_a: WBPhenotype:0000624 ! reproductive_system_development_variant is_a: WBPhenotype:0000822 ! sex_determination_variant [Term] id: WBPhenotype:0000688 name: sterile alt_id: WBPhenotype:0000311 def: "Animals generate defective gametes, are otherwise unable to reproduce or they generate progeny that are unable to reproduce." [GO:0000003, WB:WBPerson712] subset: phenotype_slim_wb synonym: "semi_sterile" EXACT [] synonym: "Ste" BROAD three_letter_name [] is_a: WBPhenotype:0001384 ! fertility_reduced [Term] id: WBPhenotype:0000689 name: maternal_sterile def: " Animals produce no or very few embryos as a result of experimental treatment. This is in contrast to sterility due to genetic perturbations (maternal effect sterility)." [WB:cab, WB:cgc5599, WB:cgc7141, WB:WBPerson557] synonym: "Reduced fecundity of injected worm" EXACT [WB:cgc5599] synonym: "Ste" BROAD three_letter_name [] synonym: "sterile_F0_fertility_problems" RELATED [] is_a: WBPhenotype:0000694 ! hermaphrodite_sterile [Term] id: WBPhenotype:0000690 name: gonad_migration_variant def: "Variations in the gross movement of the whole structure of the gonad along the bodywall, behind the gonadal leader cell and away from the developing vulva compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Gom" BROAD three_letter_name [] synonym: "gonad_migration_abnormal" NARROW [] relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_variant [Term] id: WBPhenotype:0000691 name: gonad_development_variant def: "Variations in the progression of the organ that produces gametes over time, from its formation to the mature structure compared to control." [GO:0008406, WB:WBPerson2021] synonym: "Gon" RELATED [] synonym: "gonad_development_abnormal" NARROW [] synonym: "gonadogenesis_abnormal" RELATED [] is_a: WBPhenotype:0000624 ! reproductive_system_development_variant [Term] id: WBPhenotype:0000692 name: male_sterile def: "X0 animals fail to generate viable cross-progeny." [WB:WBPerson2021] is_a: WBPhenotype:0000688 ! sterile is_a: WBPhenotype:0000863 ! male_fertility_reduced [Term] id: WBPhenotype:0000693 name: male_sperm_fertilization_defect def: "Any perturbation that renders male derived sperm ineffective at fertilizing an oocyte." [WB:WBPaper00001075, WB:WBPerson2021] is_a: WBPhenotype:0000692 ! male_sterile [Term] id: WBPhenotype:0000694 name: hermaphrodite_sterile def: "Hermaphrodites fail to generate viable self-progeny and/or cross-progeny." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000688 ! sterile is_a: WBPhenotype:0001259 ! hermaphrodite_fertility_reduced [Term] id: WBPhenotype:0000695 name: vulva_morphology_variant def: "Animals exhibit variations in the gross structure or organization of the reproductive organ required for depositing eggs and for influencing male mating behavior compared to control." [WB:WBPerson712] synonym: "vulva_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0001335 ! hermaphrodite_reproductive_system_morphology_variant [Term] id: WBPhenotype:0000696 name: everted_vulva def: "The eversion process, in which the vulval invagination is turned inside out during the final molt, is disrupted. In C.elegans, such variations in vulval eversion are primarily due to developmental defects in the somatic gonad (and sometimes vulva)." [WB:cab, WB:WBPaper00001738, WB:WBPerson2021, WB:WBPerson261] synonym: "Evl" BROAD three_letter_name [] is_a: WBPhenotype:0000695 ! vulva_morphology_variant [Term] id: WBPhenotype:0000697 name: protruding_vulva def: "Animals undergo incomplete vulval morphogenesis, resulting in the formation of a single protrusion at the site of the vulva." [WB:WBPaper00004408, WB:WBPerson2021] synonym: "Pvl" BROAD three_letter_name [] synonym: "Pvu" BROAD [] is_a: WBPhenotype:0000695 ! vulva_morphology_variant [Term] id: WBPhenotype:0000698 name: vulvaless def: "No vulval tissue is produced. In C. elegans, this is usually a result of all six vulval precursor cells adopting a tertiary fate." [WB:WBPaper00001182, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "underinduced" EXACT [] synonym: "Vul" BROAD three_letter_name [] is_a: WBPhenotype:0000219 ! vulval_cell_induction_reduced [Term] id: WBPhenotype:0000699 name: vulva_development_variant def: "Variations in the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure compared to control. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GO:0040025, WB:IA, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "vulva_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000624 ! reproductive_system_development_variant [Term] id: WBPhenotype:0000700 name: multivulva def: "Multiple vulva-like protrusions are present along the ventral side of the animal. In C. elegans, this is usually a result of all six vulval precursor cells adopting primary or secondary vulval fates." [WB:WBPaper00001182, WB:WBPerson2021] synonym: "Muv" BROAD three_letter_name [] synonym: "overinduced" EXACT [] is_a: WBPhenotype:0000218 ! vulval_cell_induction_increased [Term] id: WBPhenotype:0000701 name: epithelial_development_variant def: "Any variation in the progression of the epithelia over time, from its formation to its mature state compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "epithelial_development_abnormal" NARROW [] synonym: "hypodermal_development_abnormal" RELATED [] relationship: part_of WBPhenotype:0000619 ! epithelial_system_development_variant [Term] id: WBPhenotype:0000702 name: epithelial_cell_fusion_failure def: "Any perturbation that renders epithelial cells incompetent at undergoing membrane fusion during development." [WB:WBPaper00005122, WB:WBPerson2021] xref: PMID:15341747 is_a: WBPhenotype:0000165 ! cell_fusion_variant is_a: WBPhenotype:0000701 ! epithelial_development_variant [Term] id: WBPhenotype:0000703 name: epithelial_morphology_variant def: "Variations in the form, composition or structure of the layer of cells that cover the external surface of an organism and form the inner lining between the tissues and organs of that organism and the external environment compared to control. In C. elegans epithelial cells include epithelium of the alimentary tract, intestinal cells, hypodermis, interfacial cells and somatic gonad cells (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "epithelial_morphology_abnormal" NARROW [] synonym: "hypodermal_morphology_abnormal" RELATED [] relationship: part_of WBPhenotype:0000600 ! epithelial_system_morphology_variant [Term] id: WBPhenotype:0000704 name: excretory_canal_morphology_variant def: "Variations in the form or composition of structures made by the processes of the excretory canal cell compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory_canal_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000916 ! excretory_cell_morphology_variant [Term] id: WBPhenotype:0000705 name: intestinal_cell_development_variant def: "Any variation in the progression of an intestinal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "intestinal_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant relationship: part_of WBPhenotype:0000708 ! intestinal_development_variant [Term] id: WBPhenotype:0000706 name: gut_granule_biogenesis_reduced def: "Animals lack birefringent containing compartments in embryonic intestinal cells; however, these compartments appear in adult stages." [WB:WBPaper00032168, WB:WBPerson712] synonym: "Glo" BROAD three_letter_name [] synonym: "gut_granule_loss" RELATED [] xref: PMID:15843430 is_a: WBPhenotype:0000103 ! gut_granule_development_variant is_a: WBPhenotype:0001430 ! lysosome_organization_biogenesis_variant [Term] id: WBPhenotype:0000707 name: pharyngeal_development_variant def: "Variations in the progression of the pharynx (feeding organ) over time, from its formation to the mature structure compared to control. In C. elegans the pharynx is divided into the anterior and posterior regions. The anterior region includes the corpus (procorpus and metacorpus - first bulb) and the posterior region includes the isthmus and terminal bulb (second bulb). " [GO:0043282, WB:WBPerson2021] synonym: "pharyngeal_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_variant [Term] id: WBPhenotype:0000708 name: intestinal_development_variant def: "Variations in the progression of the intestine over time from its initial formation to its mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "endoderm_development_abnormal" RELATED [] synonym: "gut_development_abnormal" RELATED [] synonym: "intestinal_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000617 ! alimentary_system_development_variant [Term] id: WBPhenotype:0000709 name: pharyngeal_morphology_variant def: "Variations in the form or composition of the mouthparts at the anterior end of the digestive tract which contain a series of radial muscles, related neurons and epithelial cells, and several gland cells which may aid in digestion compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_variant [Term] id: WBPhenotype:0000710 name: intestinal_morphology_variant def: "Animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion (Wormatlas).\n" [WB:WBPerson2021, WB:WBPerson557] synonym: "intestinal_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_variant [Term] id: WBPhenotype:0000711 name: organism_hypersensitive_ionizing_radiation def: "Animals exhibit increased sensitivity to the effects of ion producing radiation compared to control animals." [WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0000686 ! organism_ionizing_radiation_response_variant [Term] id: WBPhenotype:0000712 name: germ_cell_ionizing_radiation_response_variant def: "Germ cells exhibit variations in their response to ionizing radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "germ_cell_ionizing_radiation_response_abnormal" NARROW [] is_a: WBPhenotype:0000987 ! germ_cell_physiology_variant [Term] id: WBPhenotype:0000715 name: muscle_excess def: "Animals exhibit a greater number of embryonic muscle cells compared to control." [WB:kmva, WB:WBPaper00001584] synonym: "Mex" BROAD three_letter_name [WB:WBPaper00001584] is_a: WBPhenotype:0000622 ! muscle_system_development_variant [Term] id: WBPhenotype:0000716 name: muscle_cell_attachment_variant def: "Any variation in the connection of a cell whose principal function is to provide contractile forces with its neighboring cells or tissues compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "muscle_cell_attachment_abnormal" NARROW [] is_a: WBPhenotype:0000990 ! muscle_cell_physiology_variant [Term] id: WBPhenotype:0000717 name: gene_expression_variant def: "Variations in the processes that convert a gene's coding sequence into a mature gene product or products (proteins or RNA), compared to control." [GO:0010467, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "gene_expression_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0000718 name: dosage_compensation_variant def: "Variations in the process of normalizing the expression level of X-linked genes between XX and XO animals compared to control." [GO:0007549, WB:WBPerson363] comment: possible XP GO:0007549 synonym: "dosage_compensation_abnormal" NARROW [] is_a: WBPhenotype:0000717 ! gene_expression_variant [Term] id: WBPhenotype:0000719 name: reporter_gene_expression_variant synonym: "reporter_gene_expression_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000720 name: pattern_of_reporter_gene_expression_variant synonym: "pattern_of_reporter_gene_expression_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000721 name: level_of_reporter_gene_expression_variant synonym: "level_of_reporter_gene_expression_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000722 name: nucleolus_variant def: "Animals exhibit variations in the appearance of nucleoli compared to control animals." [WB:cab] subset: phenotype_slim_wb synonym: "nucleolus_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000724 name: protein_secretion_variant def: "Variations in the regulated release of proteins from a cell or group of cells compared to control." [GO:0009306, WB:WBPerson2021] synonym: "protein_secretion_abnormal" NARROW [] is_a: WBPhenotype:0000258 ! cell_secretion_variant [Term] id: WBPhenotype:0000725 name: lipid_metabolism_variant def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of lipid within the organism or cell compared to control." [GO:0055088, WB:WBPaper00032000, WB:WBPaper00032082, WB:WBPerson712] synonym: "lipid_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0000726 name: ligand_binding_variant def: "Any variation of the specific binding of a molecule to its partner, which typically results in a change in cell activity, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "ligand_binding_abnormal" NARROW [] is_a: WBPhenotype:0000727 ! enzyme_activity_variant [Term] id: WBPhenotype:0000727 name: enzyme_activity_variant def: "Any variation in the function of naturally occurring macromolecular substances known as enzymes compared to control. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [GO:0003824, WB:WBPerson2021, WB:WBPerson557] synonym: "enzyme_activity_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0000728 name: exocytosis_variant def: "Variations in the process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, compared to control." [GO:0006887, WB:WBPerson2021] synonym: "exocytosis_abnormal" NARROW [] is_a: WBPhenotype:0000258 ! cell_secretion_variant [Term] id: WBPhenotype:0000729 name: cell_death_variant def: "Animals exhibit variations in any of the processes that lead to the termination of vital functions of a cell." [GO:0008219, WB:cab] subset: phenotype_slim_wb synonym: "Ced" BROAD three_letter_name [] synonym: "cell_death_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000730 name: apoptosis_variant def: "Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell." [GO:0006915, WB:WBPerson2021] synonym: "apoptosis_abnormal" NARROW [] synonym: "Ced" BROAD three_letter_name [] is_a: WBPhenotype:0001172 ! programmed_cell_death_variant [Term] id: WBPhenotype:0000731 name: germ_cell_hypersensitive_ionizing_radiation def: "Germ cells exhibit increased sensitivity to the effects of ion producing radiation compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000712 ! germ_cell_ionizing_radiation_response_variant is_a: WBPhenotype:0001324 ! cell_ionizing_radiation_response_variant [Term] id: WBPhenotype:0000732 name: DNA_metabolism_variant def: "Variations in any process that involves the maintenance, biosynthesis or accumulation of DNA in the organism compared to control." [WB:WBPerson2021] synonym: "DNA_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000733 name: catalysis_variant def: "Any variation in the catalysis of a biochemical reaction compared to control. Catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component)." [GO:0003824, WB:WBPerson2021, WB:WBPerson557] synonym: "catalysis_abnormal" NARROW [] is_a: WBPhenotype:0000727 ! enzyme_activity_variant [Term] id: WBPhenotype:0000734 name: hypodermal_cell_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the hypodermal system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "hypodermal_cell_physiology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000608 ! epithelial_system_physiology_variant [Term] id: WBPhenotype:0000735 name: endoreduplication_of_hypodermal_nuclei_variant def: "Any variation in the regulated re-replication of DNA in the hypodermal cells during a single cell cycle, compared to control." [GO:0042023, WB:WBPerson2021, WB:WBPerson557] synonym: "endoreduplication_of_hypodermal_nuclei_abnormal" NARROW [] is_a: WBPhenotype:0000734 ! hypodermal_cell_physiology_variant [Term] id: WBPhenotype:0000736 name: autophagic_cell_death_variant def: "Animals exhibit variations in the process by which their cells digest parts of their own cytoplasm, compared to control." [GO:0006914, WB:WBPerson712] synonym: "autophagic_cell_death_abnormal" NARROW [] synonym: "autophagy_abnormal" RELATED [] is_a: WBPhenotype:0000729 ! cell_death_variant [Term] id: WBPhenotype:0000737 name: germ_cell_resistant_ionizing_radiation def: "Germ cells fail to respond to the dosage of ion producing radiation that elicits a response in control animals. Alternatively, germ cells require a higher dosage or a longer exposure to ion producing radiation to elicit the same response as control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000712 ! germ_cell_ionizing_radiation_response_variant is_a: WBPhenotype:0001324 ! cell_ionizing_radiation_response_variant [Term] id: WBPhenotype:0000738 name: organism_environmental_stimulus_response_variant def: "The response to a change in the environment is altered compared to control." [WB:cab] subset: phenotype_slim_wb synonym: "organism_environmental_stimulus_response_abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000739 name: DNA_damage_response_variant def: "Variations in the activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism, compared to control." [GO:0006974, WB:WBPerson2021] synonym: "DNA_damage_response_abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell_stress_response_variant [Term] id: WBPhenotype:0000740 name: cell_cycle_variant def: "Cells of the animals exhibit variations in the progression of biochemical and morphological processes that occur during successive replication or nuclear replication events from that observed for control animals." [GO:0007049, WB:WBPerson557, WB:WBPerson712] subset: phenotype_slim_wb synonym: "cell_cycle_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000741 name: DNA_damage_checkpoint_variant def: "Mitotic cells exhibit variations in the execution of cell-cycle arrest in response to DNA damage." [WB:WBPaper00029085, WB:WBPerson2021] synonym: "DNA_damage_checkpoint_abnormal" NARROW [] is_a: WBPhenotype:0000740 ! cell_cycle_variant [Term] id: WBPhenotype:0000742 name: DNA_recombination_variant def: "Variations in the process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents, compared to control." [GO:0006310, WB:WBPerson2021] synonym: "DNA_recombination_abnormal" NARROW [] is_a: WBPhenotype:0000732 ! DNA_metabolism_variant [Term] id: WBPhenotype:0000743 name: RNAi_response_variant def: "Animals exhibit variations in their response to gene silencing triggered by double stranded RNA (RNAi), compared to control." [GO:0016246, WB:WBPerson2021] synonym: "Rde" BROAD three_letter_name [] synonym: "RNAi_response_abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000744 name: transgene_induced_cosuppression_variant def: "Animals exhibit variations in the silencing of endogenous genes after introduction of repetitive exogenous cognate DNA compared to control. " [WB:WBPaper00025139, WB:WBPerson2021, WB:WBPerson557] synonym: "transgene_induced_cosuppression_abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000745 name: transposon_silencing_variant def: "Animals exhibit variations in the activity of endogenous transposons compared to control. In C. elegans transposon activity is often measured by the rate of reversion of mutations induced by transposon insertions." [GO:0000335, WB:WBPaper00031962, WB:WBPerson712] synonym: "transposon_silencing_abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000746 name: cell_division_variant def: "Any variation that alters the physical partitioning and separation of a cell into daughter cells compared to control." [GO:0051301, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "cell_division_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000747 name: pharyngeal_contraction_defective def: "Any defects in the muscle contractions that control feeding. Contractions are necessary for bacterial uptake from the surrounding environment." [WB:WBPaper00001696] is_a: WBPhenotype:0000980 ! pharyngeal_contraction_variant [Term] id: WBPhenotype:0000748 name: asymmetric_cell_division_defective_early_emb def: "Symmetric (PAR-like) divisions or excessive posterior displacement (zyg-8 like phenotypes)." [WB:cab, WB:cgc7141] synonym: "asymmetric_cell_division_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal is_a: WBPhenotype:0001235 ! cell_division_polarity_variant [Term] id: WBPhenotype:0000749 name: embryonic_development_variant def: "Variations in the progression of an embryo over time, from zygote formation to hatching compared to control." [GO:0009790, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "developmental_defects_detected_in_embryos" RELATED [] synonym: "embryonic_development_abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism_development_variant [Term] id: WBPhenotype:0000750 name: larval_development_variant def: "Variations in the progression of a larva over time, from its formation to the mature structure compared to control. The larva is the early, immature form of an animal between hatching and adulthood." [GO:0002164, WB:WBPerson2021] synonym: "larval_development_abnormal" NARROW [] is_a: WBPhenotype:0000049 ! postembryonic_development_variant [Term] id: WBPhenotype:0000751 name: L1_larval_development_variant def: "Variations in the progression of a newly hatched animal through the first larval molt compared to control." [WB:WBPerson2021] synonym: "L1_larval_development_abnormal" NARROW [] is_a: WBPhenotype:0000750 ! larval_development_variant [Term] id: WBPhenotype:0000752 name: L2_larval_development_variant def: "Variations in the progression of the second larval stage compared to control." [WB:WBPerson557] synonym: "L2_larval_development_abnormal" NARROW [] is_a: WBPhenotype:0000750 ! larval_development_variant [Term] id: WBPhenotype:0000753 name: L3_larval_development_variant def: "Variations in the progression of the third larval stage compared to control." [WB:WBPerson557] synonym: "L3_larval_development_abnormal" NARROW [] is_a: WBPhenotype:0000750 ! larval_development_variant [Term] id: WBPhenotype:0000754 name: L4_larval_development_variant def: "Variations in the progression of the fourth larval stage compared to control." [WB:WBPerson557] synonym: "L4_larval_development_abnormal" NARROW [] is_a: WBPhenotype:0000750 ! larval_development_variant [Term] id: WBPhenotype:0000755 name: L1_L2_molt_defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L1 to L2 transition." [GO:0018996] synonym: "L1_L2_molt_abnormal" NARROW [] synonym: "L1_molt" RELATED [] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000756 name: L2_L3_molt_defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L2 to L3 transition." [GO:0018996] synonym: "L2_L3_molt_abnormal" NARROW [] synonym: "L2_molt" RELATED [] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000757 name: L3_L4_molt_defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L3 to L4 transition." [GO:0018996] synonym: "L3_L4_molt_abnormal" NARROW [] synonym: "L3_molt" RELATED [] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000758 name: L4_adult_molt_defect def: "Animals exhibit defects in the process of shedding, part or all of its cuticle, during cuticle replacement that punctuates L4 to adult transition." [GO:0018996] synonym: "L4_adult_molt_abnormal" NARROW [] synonym: "L4_molt" RELATED [] is_a: WBPhenotype:0000638 ! molt_defect [Term] id: WBPhenotype:0000759 name: spindle_defective_early_emb def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubules and associated molecules that form between opposite poles of a eukaryotic cell during a cell cycle." [GO:0007051, WB:WBPerson2021] comment: Possible XP synonym: "Emb" BROAD [] synonym: "Spd" BROAD three_letter_name [] synonym: "spindle_abnormal" NARROW [] is_a: WBPhenotype:0000764 ! embryonic_cell_organization_biogenesis_variant is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000760 name: spindle_orientation_defective_early_emb def: "The alignment of the spindle relative to other cellular structures in the cells of an embryo varies from that observed in control animals." [WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "spindle_orientation_abnormal" NARROW [] synonym: "Spn" BROAD three_letter_name [] is_a: WBPhenotype:0000761 ! spindle_position_orientation_defective_early_emb is_a: WBPhenotype:0001681 ! spindle_orientation_variant [Term] id: WBPhenotype:0000761 name: spindle_position_orientation_defective_early_emb def: "Early embryos exhibit defects in the placement or the alignment of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Spi" RELATED [] synonym: "spindle_position_orientation_abnormal" NARROW [] synonym: "Spo" BROAD three_letter_name [] is_a: WBPhenotype:0001102 ! mitotic_spindle_defective_early_emb [Term] id: WBPhenotype:0000762 name: spindle_position_defective_early_emb def: "Early embryos exhibit defects in the placement of the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [GO:0051653, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "Abs" BROAD three_letter_name [] synonym: "Emb" BROAD [] synonym: "spindle_position_abnormal" NARROW [] is_a: WBPhenotype:0000761 ! spindle_position_orientation_defective_early_emb [Term] id: WBPhenotype:0000763 name: embryonic_cell_physiology_variant def: "Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for an embryonic cell to carry out its normal function and activities or be able to perceive and respond to stimuli." [GO:0009987, WB:WBPerson557] subset: phenotype_slim_wb synonym: "embryonic_cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000764 name: embryonic_cell_organization_biogenesis_variant def: "Variations in the processes that are carried out at in the embryo which results in its formation or the arrangement of constituent parts, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "embryonic_cell_organization_biogenesis_abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic_development_variant is_a: WBPhenotype:0000763 ! embryonic_cell_physiology_variant is_a: WBPhenotype:0010002 ! cell_organization_biogenesis_variant [Term] id: WBPhenotype:0000765 name: spindle_elongation_integrity_defective_early_emb def: "The embryos exhibit defects in the cell cycle process whereby the distance is lengthened between poles of the spindle. " [GO:0051231, WB:cab, WB:cgc7141, WB:WBPerson2021] comment: possible XP synonym: "Emb" BROAD three_letter_name [] synonym: "spindle_elongation_integrity_abnormal" NARROW [] is_a: WBPhenotype:0001102 ! mitotic_spindle_defective_early_emb [Term] id: WBPhenotype:0000766 name: centrosome_pair_and_associated_pronuclear_rotation_variant def: "Any variation in the rotation of the centrosome-pronuclear complex after its migration toward the center of the embryo, compared to control." [WB:WBPaper00004895, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "centrosome_pair_and_associated_pronuclear_rotation_abnormal" NARROW [] synonym: "Rot" BROAD three_letter_name [] is_a: WBPhenotype:0000764 ! embryonic_cell_organization_biogenesis_variant [Term] id: WBPhenotype:0000767 name: integrity_of_membranous_organelles_defective_early_emb def: "Sparse or enlarged yolk granules." [WB:cab, WB:WBPaper00025054] synonym: "Emb" BROAD three_letter_name [] synonym: "integrity_of_membranous_organelles_abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000768 name: cytoplasmic_structure_defective_early_emb def: "Areas devoid of yolk granules throughout the embryo." [WB:cab, WB:cgc7141] synonym: "Aberrant_Cytoplasmic_Structure" RELATED [] synonym: "cellular_structure_disorganized" RELATED [] synonym: "cytoplasmic_structure_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001081 ! cytoplasmic_morphology_defective_early_emb [Term] id: WBPhenotype:0000769 name: cytoplasmic_appearance_defective_early_emb def: "Embryos exhibit defects in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control embryos." [WB:WBPerson2021, WB:WBPerson557] synonym: "cytoplasmic_appearance_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal is_a: WBPhenotype:0001427 ! cytoplasmic_appearance_variant [Term] id: WBPhenotype:0000770 name: embryonic_cell_morphology_variant def: "Animals exhibit variations in the appearance of embryonic cells compared to control." [WB:cab] subset: phenotype_slim_wb synonym: "embryonic_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000771 name: centrosome_attachment_defective_early_emb def: "Centrosomes detach from the male pronucleus." [WB:cab, WB:cgc7141] synonym: "centrosome_attachment_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000770 ! embryonic_cell_morphology_variant is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0000772 name: sister_chromatid_segregation_defective_early_emb def: "Daughter nuclei are deformed and stay close to central cortex, cytokinesis defects." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] synonym: "sister_chromatid_segregation_abnormal" NARROW [] is_a: WBPhenotype:0000773 ! chromosome_segregation_variant is_a: WBPhenotype:0001078 ! cytokinesis_defective_early_emb [Term] id: WBPhenotype:0000773 name: chromosome_segregation_variant def: "Any variation in the processes that regulate the apportionment of chromosomes to each of two daughter cells compared to control." [GO:0007059, WB:kmva, WB:WBPerson2021, WB:WBPerson557] synonym: "chromosome_segregation_abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0000774 name: gametogenesis_variant def: "Any variation in the processes that govern the generation and maintenance of gametes compared to control." [GO:0007276, WB:WBPerson2021] synonym: "gametogenesis_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000775 name: meiosis_variant def: "Variations in the specialized nuclear and cytoplasmic divisions of a single diploid cell, whose specific outcome is the formation of four haploid daughter cells compared to control. Meiosis occurs during the formation of gametes." [GO:0007126, WB:WBPerson2021] synonym: "germ_cell_meiosis_abnormal" RELATED [] synonym: "germ_cell_meiosis_variant" RELATED [] synonym: "Mei" RELATED [] synonym: "meiosis_abnormal" NARROW [] is_a: WBPhenotype:0000812 ! germ_cell_development_variant [Term] id: WBPhenotype:0000776 name: passage_through_meiosis_defective_early_emb def: "Male and female PNs not visible; embryo often fills egg shell completely." [WB:cab, WB:cgc71441] synonym: "Emb" BROAD three_letter_name [] synonym: "passage_through_meiosis_abnormal" NARROW [] is_a: WBPhenotype:0000775 ! meiosis_variant is_a: WBPhenotype:0001041 ! meiosis_defective_early_emb [Term] id: WBPhenotype:0000777 name: polar_body_extrusion_defective_early_emb def: "Unextruded or resorbed polar body(ies) leading to an extra PNs in P0 and/or extra karyomeres in AB/P1." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] synonym: "polar_body_extrusion_abnormal" NARROW [] is_a: WBPhenotype:0000775 ! meiosis_variant is_a: WBPhenotype:0001147 ! polar_body_defective_early_emb [Term] id: WBPhenotype:0000778 name: feeding_inefficient def: "Animals are unable to ingest nutrients at a rate similar to control animals." [WB:WBPaper00032342, WB:WBPerson712] is_a: WBPhenotype:0000659 ! feeding_behavior_variant [Term] id: WBPhenotype:0000779 name: late_embryonic_arrest def: "Cessation of development during the final stages of embryogenesis. In C. elegans, this stage normally occurs 620-800 min after the first cleavage at 20C and is the stage after elongation." [WB:WBPerson101] is_a: WBPhenotype:0000867 ! embryonic_arrest [Term] id: WBPhenotype:0000780 name: shaker def: "Animals rotate back and forth around their longitudinal axes." [WB:cab, WB:cgc914] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0000781 name: thin_filament_variant def: "Any variation in the extremely thin elongated cytoplasmic filament, usually composed principally of actin protein to form a myofilament lattice, as in muscle cells compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "thin_filament_abnormal" NARROW [] relationship: part_of WBPhenotype:0000553 ! muscle_ultrastructure_disorganized [Term] id: WBPhenotype:0000782 name: thick_filament_variant def: "Animals exhibit variations in the form, structure or composition of a robust elongated cytoplasmic filament composed principally of myosin protein compared to control animals. In C. elegans, thick filaments also contain paramyosin and twitchin (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "thick_filament_abnormal" NARROW [] relationship: part_of WBPhenotype:0000553 ! muscle_ultrastructure_disorganized [Term] id: WBPhenotype:0000783 name: M_line_absent def: "Animals exhibit variations in the form, structure or composition of a planar structure within the muscle sarcomere which lies midway within the thick filament (A) band, attaching to the plasma membrane at its base and running up towards the inward surface of the myofilament lattice, compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000782 ! thick_filament_variant [Term] id: WBPhenotype:0000784 name: male_fertility_variant def: "Males exhibit variations in the time of onset or duration of the fertile period owing to differences in sperm competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_fertility_abnormal" NARROW [] is_a: WBPhenotype:0000145 ! fertility_variant [Term] id: WBPhenotype:0000785 name: body_part_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular body part compared to control animals." [WB:WBPerson557] synonym: "body_part_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000278 ! body_region_pigmentation_variant [Term] id: WBPhenotype:0000786 name: body_axis_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency along a particular body axis compared to control." [WB:WBPerson557] synonym: "body_axis_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000278 ! body_region_pigmentation_variant [Term] id: WBPhenotype:0000787 name: posterior_pale def: "Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the posterior body axis compared to control." [WB:WBPerson557] is_a: WBPhenotype:0000984 ! posterior_pigmentation_variant [Term] id: WBPhenotype:0000788 name: anterior_pale def: "Animals have decreased accumulation or expression of biochromes or any other substances that causes increased translucency of the anterior body axis compared to control." [WB:WBPerson557] is_a: WBPhenotype:0000971 ! anterior_pigmentation_variant [Term] id: WBPhenotype:0000789 name: fluoxetine_hypersensitive def: "Animals respond to fluoxetine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0000790 name: fluoxetine_resistant def: "Animals fail to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0000791 name: nose_resistant_to_fluoxetine def: "The nose of an animal fails to respond to the concentration of fluoxetine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000790 ! fluoxetine_resistant [Term] id: WBPhenotype:0000792 name: anterior_body_morphology_variant alt_id: WBPhenotype:0001491 def: "Animals exhibit variations in the form, structure or composition of the anatomy contained in the anterior region, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior_body_morphology_abnormal" NARROW [] synonym: "anterior_region_morphology_abnormal" NARROW [] synonym: "anterior_region_morphology_variant" EXACT [] is_a: WBPhenotype:0000072 ! body_morphology_variant is_a: WBPhenotype:0000581 ! body_axis_morphology_variant [Term] id: WBPhenotype:0000793 name: posterior_body_morphology_variant alt_id: WBPhenotype:0001490 def: "Animals exhibit variations in the form, structure or composition of the anatomy contained in the posterior region, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior_body_morphology_abnormal" NARROW [] synonym: "posterior_region_morphology_abnormal" NARROW [] synonym: "posterior_region_morphology_variant" EXACT [] is_a: WBPhenotype:0000072 ! body_morphology_variant is_a: WBPhenotype:0000581 ! body_axis_morphology_variant [Term] id: WBPhenotype:0000794 name: posterior_body_thin def: "The posterior part of the worm exhibits a reduced girth compared to a control animal of the same developmental stage." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000793 ! posterior_body_morphology_variant [Term] id: WBPhenotype:0000795 name: body_axis_behavior_variant def: "Variations in the specific actions or reactions of one of the longitudinal axes of the extended body of the worm in response to external or internal stimuli compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_axis_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000522 ! organism_region_behavior_variant [Term] id: WBPhenotype:0000796 name: posterior_body_uncoordinated def: "The movement of the posterior part of the worm is not coordinated with the rest of the body." [WB:cab] is_a: WBPhenotype:0000797 ! posterior_body_behavior_variant [Term] id: WBPhenotype:0000797 name: posterior_body_behavior_variant def: "Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the tail of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior_body_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000795 ! body_axis_behavior_variant [Term] id: WBPhenotype:0000798 name: anterior_body_behavior_variant def: "Variations in the specific actions or reactions of the longitudinal axis that spans from the midpoint to the tip of the head of an animal in response to external or internal stimuli compared to that observed in control animals (Wormatlas).\n" [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior_body_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000795 ! body_axis_behavior_variant [Term] id: WBPhenotype:0000799 name: anterior_region_development_variant def: "Variations in the progression of an animal's anatomy contained in the anterior region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior_region_development_abnormal" NARROW [] is_a: WBPhenotype:0000578 ! body_axis_development_variant [Term] id: WBPhenotype:0000800 name: posterior_region_development_variant def: "Variations in the progression of an animal's anatomy contained in the posterior region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior_region_development_abnormal" NARROW [] is_a: WBPhenotype:0000578 ! body_axis_development_variant [Term] id: WBPhenotype:0000801 name: ventral_region_development_variant def: "Variations in the progression of an animal's anatomy contained in the ventral region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "ventral_region_development_abnormal" NARROW [] is_a: WBPhenotype:0000578 ! body_axis_development_variant [Term] id: WBPhenotype:0000802 name: dorsal_region_development_variant def: "Variations in the progression of an animal's anatomy contained in the dorsal region over time, compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dorsal_region_development_abnormal" NARROW [] is_a: WBPhenotype:0000578 ! body_axis_development_variant [Term] id: WBPhenotype:0000803 name: head_development_variant def: "Variations in the progression of the anterior end of the animal over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "head_development_abnormal" NARROW [] is_a: WBPhenotype:0000579 ! organism_segment_development_variant [Term] id: WBPhenotype:0000804 name: body_development_variant def: "Variations in the progression of the overall structure or appearance of the animal over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_development_abnormal" NARROW [] is_a: WBPhenotype:0000579 ! organism_segment_development_variant [Term] id: WBPhenotype:0000805 name: tail_development_variant def: "Any variation in the process whose specific outcome is the progression of the tail over time, from its formation to the mature structure, compared to control. The tail includes the posterior region that spans from the rectum to the end." [WB:WBPerson2021] synonym: "tail_development_abnormal" NARROW [] is_a: WBPhenotype:0000579 ! organism_segment_development_variant [Term] id: WBPhenotype:0000806 name: hermaphrodite_fertility_variant def: "Hermaphrodite exhibit variations in the time of onset or duration of the fertile period, or production of viable offspring, including number and state of fertilized eggs laid compared to control." [WB:WBPerson712] synonym: "hermaphrodite_fertility_abnormal" NARROW [] is_a: WBPhenotype:0000145 ! fertility_variant [Term] id: WBPhenotype:0000807 name: G_lineages_variant def: "The descendants of the G1 or G2 exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "G_lineages_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000808 name: K_lineage_variant def: "The descendants of the K precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "K_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000809 name: male_specific_lineage_variant def: "The descendants of a male specific precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male_specific_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000810 name: blast_cell_development_variant def: "Any variation in the progression of a blast cell (precursor cell) over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "blast_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000811 name: epithelial_cell_development_variant def: "Any variation in the progression of an epithelial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "epithelial_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000812 name: germ_cell_development_variant def: "Variations in the progression of the immature germ cell over time, from its formation to the mature structure (gamete) compared to control." [GO:0007281, WB:WBPerson2021] synonym: "germ_cell_development_abnormal" NARROW [] synonym: "germline_development_abnormal" RELATED [] relationship: part_of WBPhenotype:0000774 ! gametogenesis_variant [Term] id: WBPhenotype:0000813 name: gland_cell_development_variant def: "Any variation in the progression of a gland cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "gland_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000814 name: marginal_cell_development_variant def: "Any variation in the progression of a marginal cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A marginal cell is a pharyngeal cell that connects the basement membrane to the apices of the triangle-shaped pharyngeal lumen." [WB:WBPerson2021] synonym: "marginal_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000815 name: muscle_cell_development_variant def: "Any variation in the progression of a muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "muscle_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000816 name: neuron_development_variant def: "Variations in the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [GO:0048666, WB:WBPerson2021] synonym: "neuron_development_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000817 name: uterine_vulval_cell_development_variant def: "Variations in the progression of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) over time from an initial condition to a later condition compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "uterine_vulval_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0000818 name: adult_behavior_variant def: "Activity characteristic of an adult worm is altered compared to control." [WB:cab] synonym: "adult_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000819 ! postembryonic_behavior_variant [Term] id: WBPhenotype:0000819 name: postembryonic_behavior_variant def: "Behavior characteristic of postembryonic stage(s) is altered compared to control." [WB:cab] synonym: "postembryonic_behavior_abnormal" NARROW [] is_a: WBPhenotype:0001000 ! developmental_behavior_variant [Term] id: WBPhenotype:0000820 name: embryonic_behavior_variant def: "Activity characteristic of an embryo is altered compared to control." [WB:cab] synonym: "embryonic_behavior_abnormal" NARROW [] is_a: WBPhenotype:0001000 ! developmental_behavior_variant [Term] id: WBPhenotype:0000821 name: sexually_dimorphic_behavior_variant def: "Animals exhibit variations in sex-specific behaviors compared to control." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "sexually_dimorphic_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0000822 name: sex_determination_variant def: "Any variation in the processes that govern the sexually dimorphic development of germline or somatic tissue compared to control." [WB:kmva] synonym: "sex_determination_abnormal" NARROW [] synonym: "sex_specific_development_abnormal" RELATED [] is_a: WBPhenotype:0000930 ! sexually_dimorphic_development_variant [Term] id: WBPhenotype:0000823 name: germline_proliferation_variant def: "Nuclear divisions in the germ line are either expanded are reduced compared to control." [WB:cab] synonym: "germ_cell_proliferation_abnormal" RELATED [] synonym: "germ_line_proliferation_abnormal" EXACT [] synonym: "germline_proliferation_abnormal" NARROW [] synonym: "glp" BROAD three_letter_name [] is_a: WBPhenotype:0000812 ! germ_cell_development_variant [Term] id: WBPhenotype:0000824 name: embryonic_cell_lineage_variant def: "The descendants of an embryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "embryonic_cell_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000093 ! lineage_variant [Term] id: WBPhenotype:0000825 name: postembryonic_cell_lineage_variant def: "The descendants of a postembryonic precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "postembryonic_cell_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000093 ! lineage_variant [Term] id: WBPhenotype:0000826 name: H_lineages_variant def: "The descendants of H1 or H2 cells exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "H_lineages_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000827 name: V_lineages_variant def: "The descendants of any of the V precursor cells (V1-V6) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "V_lineages_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000828 name: T_lineages_variant def: "The descendants of TL or TR cells exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "T_lineages_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000829 name: Q_lineage_variant def: "The descendants of Q L or QR cells exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Q_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000830 name: B_lineage_variant def: "The descendants of the B cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "B_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male_specific_lineage_variant [Term] id: WBPhenotype:0000831 name: Y_lineage_variant def: "The descendants of the Y cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Y_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male_specific_lineage_variant [Term] id: WBPhenotype:0000832 name: C_lineage_variant def: "The descendants of the C blastomere exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPaper00001584, WB:WBPerson2021] synonym: "C_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_variant [Term] id: WBPhenotype:0000833 name: U_lineage_variant def: "The descendants of the U cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "U_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male_specific_lineage_variant [Term] id: WBPhenotype:0000834 name: E_lineage_variant def: "The descendants of the E blastomere exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPaper00002870, WB:WBPerson2021] synonym: "E_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_variant [Term] id: WBPhenotype:0000835 name: F_lineage_variant def: "The descendants of the F cell (which divides only in the males) exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "F_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male_specific_lineage_variant [Term] id: WBPhenotype:0000836 name: gonadal_lineage_variant def: "The descendants of a gonadal precursor cell exhibit altered developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "gonadal_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000837 name: hermaphrodite_gonadal_lineage_variant def: "The descendants of a gonadal precursor cell exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "hermaphrodite_gonadal_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000836 ! gonadal_lineage_variant [Term] id: WBPhenotype:0000838 name: male_gonadal_lineage_variant def: "The descendants of a gonadal precursor cell exhibit altered developmental programs in the male compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male_gonadal_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male_specific_lineage_variant is_a: WBPhenotype:0000836 ! gonadal_lineage_variant [Term] id: WBPhenotype:0000839 name: Z1_hermaphrodite_lineage_variant def: "Z1 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Z1_hermaphrodite_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000837 ! hermaphrodite_gonadal_lineage_variant [Term] id: WBPhenotype:0000840 name: Z4_hermaphrodite_lineage_variant def: "Z4 descendants exhibit altered developmental programs in the hermaphrodite compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Z4_hermaphrodite_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000837 ! hermaphrodite_gonadal_lineage_variant [Term] id: WBPhenotype:0000841 name: Z1_male_lineage_variant def: "Z1 descendents exhibit altered developmental programs in the male compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Z1_male_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000838 ! male_gonadal_lineage_variant [Term] id: WBPhenotype:0000842 name: Z4_male_lineage_variant def: "Z4 descendants exhibit altered developmental programs in the male compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "Z4_male_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000838 ! male_gonadal_lineage_variant [Term] id: WBPhenotype:0000843 name: male_mating_efficiency_reduced def: "The number of cross progeny sired by males is reduced compared to control." [WB:WBPaper00000179, WB:WBPaper00000608, WB:WBPerson557] is_a: WBPhenotype:0000647 ! copulation_variant [Term] id: WBPhenotype:0000844 name: serotonin_induced_pumping_variant def: "Pharyngeal pumping is not influenced by serotonin treatment in the same manner as control animals." [WB:WBPerson2021] synonym: "serotonin_induced_pumping_abnormal" NARROW [] is_a: WBPhenotype:0000024 ! serotonin_resistant is_a: WBPhenotype:0001232 ! serotonin_response_variant is_a: WBPhenotype:0001285 ! induced_pharyngeal_pumping_variant [Term] id: WBPhenotype:0000845 name: levamisole_response_variant def: "Animals exhibit variations in the response to the addition of levamisole compared to that observed in control animals. Levamisole is a cholinergic agonist." [WB:WBPerson557] synonym: "levamisole_response_abnormal" NARROW [] synonym: "tetramisole_response_abnormal" RELATED [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0000846 name: presynaptic_region_physiology_variant def: "Animals exhibit variations in any physical or chemical process in the region of the vesicle-filled varicosities of the synapse compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "presynaptic_region_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic_transmission_variant [Term] id: WBPhenotype:0000847 name: presynaptic_component_localization_variant def: "Animals display variations in the distribution of the constituents that make up the synaptic machinery such as those required for priming, docking or fusion of vesicles at the active zone, compared to that observed in control animals." [WB:WBPaper00027305, WB:WBPerson712] synonym: "presynaptic_component_localization_abnormal" NARROW [] synonym: "synaptic_component_localization_abnormal" RELATED [] synonym: "synaptic_machinery_localization_abnormal" RELATED [] relationship: part_of WBPhenotype:0001321 ! presynaptic_region_morphology_variant [Term] id: WBPhenotype:0000848 name: developmental_delay def: "The developmental progression of an animal over time, from its formation to its mature structure is delayed compared to control. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000043 ! general_pace_of_development_variant [Term] id: WBPhenotype:0000849 name: amphid_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for an amphid to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557] synonym: "amphid_physiology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000652 ! sensory_system_variant [Term] id: WBPhenotype:0000850 name: touch_resistant_anterior_body def: "Animal does not respond to stroking in the anterior body region with a hair or similar fiber compared to control. In C. elegans, the anterior region is defined as the body region that lies between the posterior bulb of the pharynx and the vulva." [WB:WBPaper00000502, WB:WBPaper00001705, WB:WBPerson557] synonym: "touch_insensitive_anterior_body" RELATED [] is_a: WBPhenotype:0000456 ! touch_resistant [Term] id: WBPhenotype:0000851 name: ciliated_neuron_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the ciliated neuron to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "ciliated_neuron_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000991 ! neuron_physiology_variant [Term] id: WBPhenotype:0000852 name: coelomocyte_development_variant def: "Variations in the progression of a free-floating spherical cell lying in the pseudocoelomic cavity of animals that can endocytose many compounds, possibly for immune surveillance, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "coelomocyte_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000618 ! coelomic_system_development_variant [Term] id: WBPhenotype:0000853 name: intraflagellar_transport_variant def: "Variations in the bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum, compared to control." [GO:0042073, WB:WBPerson2021] synonym: "IFT_abnormal" RELATED [] synonym: "intraflagellar_transport_abnormal" NARROW [] is_a: WBPhenotype:0000851 ! ciliated_neuron_physiology_variant [Term] id: WBPhenotype:0000854 name: intraflagellar_transport_defective def: "Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is disrupted." [WB:WBPerson2021] synonym: "ift_defective" RELATED [] is_a: WBPhenotype:0000853 ! intraflagellar_transport_variant [Term] id: WBPhenotype:0000855 name: pseudocoelom_development_variant def: "Variations in the progression of the fluid-filled space which separates the bodywall from internal organs over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "pseudocoelom_development_abnormal" NARROW [] is_a: WBPhenotype:0000200 ! pericellular_component_development_variant [Term] id: WBPhenotype:0000856 name: excretory_gland_cell_development_variant def: "Any variation in the progression of a gland cell of the secretory-excretory system over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "excretory_gland_cell_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000620 ! excretory_secretory_system_development_variant relationship: part_of WBPhenotype:0000813 ! gland_cell_development_variant [Term] id: WBPhenotype:0000857 name: excretory_cell_development_variant def: "Variations in the progression of a protokidney cell with an internal lumen that is suggested to collect and secrete salt solutions outward via the excretory sinus, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory_canal_cell_development_abnormal" RELATED [] synonym: "excretory_cell_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000621 ! excretory_system_development_variant [Term] id: WBPhenotype:0000858 name: excretory_duct_cell_development_variant def: "Variations in the progression of an interfacial epithelial cell which forms a lumen to receive the outflow of the excretory gland and excretory canal cells, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory_duct_cell_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000621 ! excretory_system_development_variant [Term] id: WBPhenotype:0000859 name: excretory_socket_cell_development_variant def: "Variations in the progression of an interfacial epithelial cell which links excretory duct to hypodermis, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory_pore_cell_development_abnormal" RELATED [] synonym: "excretory_socket_cell_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000621 ! excretory_system_development_variant [Term] id: WBPhenotype:0000860 name: nonstriated_muscle_development_variant def: "Variations in the progression of muscle cells that lack transverse striations in its constituent fibers and are almost always involuntary, over time from an initial condition to a later condition compared to control animals." [GO:0051145, WB:WBPerson2021, WB:WBPerson557] synonym: "nonstriated_muscle_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000622 ! muscle_system_development_variant [Term] id: WBPhenotype:0000861 name: body_wall_muscle_development_variant def: "Any variation in the progression of the principal muscle cell type whose contractile activity generates body motion in the nematode over time compared to control. In C. elegans they consist of 95 unfused cells in the adult organized into four muscle quadrants. Their sarcomeres are obliquely striated and lie lengthwise along the bodywall (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_wall_muscle_development_abnormal" NARROW [] synonym: "somatic_muscle_development_abnormal" RELATED [] synonym: "striated_muscle_development_abnormal" RELATED [] is_a: WBPhenotype:0000921 ! striated_muscle_development_variant [Term] id: WBPhenotype:0000862 name: bloated def: "Worms appears turgid or swollen as a result of an excess number of eggs being retained in the uterus." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000545 ! egg_retention [Term] id: WBPhenotype:0000863 name: male_fertility_reduced def: "Males exhibit a reduction in the production of new individuals owing to defects in sperm competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000784 ! male_fertility_variant [Term] id: WBPhenotype:0000864 name: early_elongation_arrest def: "Cessation of development during the initial period of elongation. In C. elegans, this period refers to the conversion of the bean-shaped embryo into the two-fold- shaped embryo." [WB:WBPaper00027244] is_a: WBPhenotype:0000867 ! embryonic_arrest [Term] id: WBPhenotype:0000865 name: amphid_sheath_cell_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for a amphid sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557] synonym: "amphid_sheath_cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000849 ! amphid_physiology_variant [Term] id: WBPhenotype:0000866 name: germ_cell_arrest def: "Germ cells fail to undergo meiotic differentiation to form mature gametes." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000823 ! germline_proliferation_variant [Term] id: WBPhenotype:0000867 name: embryonic_arrest def: "Cessation of development during any stage occurring after fertilization and until hatching compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0000868 name: paralyzed_body def: "All parts of the animal are immobilized except for the head." [WB:cab] is_a: WBPhenotype:0000644 ! paralyzed [Term] id: WBPhenotype:0000869 name: mitochondria_morphology_variant_muscle synonym: "mitochondria_morphology_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000870 name: mitochondria_morphology_variant_epithelial synonym: "mitochondria_morphology_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0000871 name: connected_mitochondria_epithelial is_obsolete: true [Term] id: WBPhenotype:0000872 name: connected_mitochodria_muscle is_obsolete: true [Term] id: WBPhenotype:0000873 name: G1_checkpoint_variant def: "Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G1 phase of the mitotic cell cycle just before entry into S phase, compared to control cells." [GO:0007089, WB:WBPerson557, WB:WBPerson712] synonym: "G1_checkpoint_abnormal" NARROW [] is_a: WBPhenotype:0000741 ! DNA_damage_checkpoint_variant [Term] id: WBPhenotype:0000874 name: G2_checkpoint_variant def: "Mitotic cells exhibit variations during the passage through a cell cycle control point late in the G2 phase of the mitotic cell cycle just before entry into M phase, nuclear division, compared to control cells." [GO:0031576, WB:WBPerson557, WB:WBPerson712] synonym: "G2_checkpoint_abnormal" NARROW [] is_a: WBPhenotype:0000741 ! DNA_damage_checkpoint_variant [Term] id: WBPhenotype:0000875 name: S_phase_checkpoint_variant def: "Mitotic cells exhibit variations during the passage through a cell cycle control point late in the S phase of the mitotic cell cycle, which ensures DNA replication is complete, compared to control cells." [GO:0031574, WB:WBPerson712] synonym: "S_phase_checkpoint_abnormal" NARROW [] is_a: WBPhenotype:0000741 ! DNA_damage_checkpoint_variant [Term] id: WBPhenotype:0000876 name: organism_osmotic_stress_response_variant def: "Animals exhibit variations in their response to osmotic stress compared to that observed in control animals." [WB:WBPerson557] synonym: "organism_osmotic_stress_response_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0000877 name: amphid_sheath_cell_development_variant def: "Any variation in the progression of a sheath cell of the amphid sensillum over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "amphid_sheath_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000950 ! neuronal_sheath_cell_development_variant [Term] id: WBPhenotype:0000878 name: chemosensory_neuron_development_variant def: "Any variation in the progression of a chemosensory neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "chemosensory_neuron_development_abnormal" NARROW [] is_a: WBPhenotype:0000816 ! neuron_development_variant [Term] id: WBPhenotype:0000879 name: telomere_length_regulation_variant def: "Animals exhibit variations in the processes that are required to maintain the length of telomeric DNA from generation to generation compared to control" [GO:0032204, WB:WBPaper00031585, WB:WBPerson712] synonym: "telomere_length_regulation_abnormal" NARROW [] is_a: WBPhenotype:0001673 ! telomere_homeostasis_variant [Term] id: WBPhenotype:0000880 name: axon_development_variant def: "Any variation in the processes that influence the generation of neuronal extensions, that carry efferent (outgoing) action potentials from the cell body towards target cells compared to control." [GO:0007409, WB:WBPerson2021] synonym: "axon_development_abnormal" NARROW [] synonym: "axonogenesis_abnormal" RELATED [] is_a: WBPhenotype:0000944 ! neurite_development_variant [Term] id: WBPhenotype:0000881 name: cilia_mislocalized def: "Animals exhibit variations in the placement of the microtuble-based dendritic projections in relation to the sensillum neuron, from that observed in control animals." [WB:WBPerson712] is_a: WBPhenotype:0001526 ! ciliated_neuron_morphology_variant [Term] id: WBPhenotype:0000882 name: dendrite_development_variant def: "Any variation in the processes that influence the generation of neuronal extensions, that carry afferent (incoming) action potentials towards the cell body compared to control." [GO:0016358, WB:WBPerson2021] synonym: "dendrite_development_abnormal" NARROW [] is_a: WBPhenotype:0000944 ! neurite_development_variant [Term] id: WBPhenotype:0000883 name: nerve_ring_development_variant def: "Variations in the progression of the the major zone of overlapping axons in the head, which encircles the isthmus of the pharynx to form a tightly packed ring-like structure on the outside of the pharynx, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "nerve_ring_development_abnormal" NARROW [] is_a: WBPhenotype:0000945 ! neuropil_development_variant [Term] id: WBPhenotype:0000884 name: AWB_morphology_variant def: "Animals exhibit variations in the structure or organization of either of a set of two ciliated wing neurons, AWBL or AWBR, of the amphid sensilla, compared to that observed in control animals." [WB:WBPaper00000938, WB:WBPerson712] comment: WBbt:0005671 synonym: "AWB_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000256 ! amphid_morphology_variant [Term] id: WBPhenotype:0000885 name: engulfment_variant def: "Any variation in the removal of a cell corpse, by a neighboring cell or a phagocyte compared to control." [GO:0043652, WB:WBPerson2021] synonym: "engulfment_abnormal" NARROW [] synonym: "phagocytosis_abnormal" RELATED [] is_a: WBPhenotype:0000730 ! apoptosis_variant [Term] id: WBPhenotype:0000886 name: Variant def: "Animals exhibit variations compared to a given control." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "Abnormal" NARROW [] [Term] id: WBPhenotype:0000887 name: hermaphrodite_behavior_variant def: "Animals exhibit variations in hermaphrodite-specific behaviors compared to control." [WB:WBPerson557] synonym: "hermaphrodite_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000821 ! sexually_dimorphic_behavior_variant [Term] id: WBPhenotype:0000888 name: male_behavior_variant def: "Animals exhibit variations in male-specific behaviors compared to control." [WB:WBPerson557] synonym: "male_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000821 ! sexually_dimorphic_behavior_variant [Term] id: WBPhenotype:0000889 name: sexually_dimorphic_physiology_variant def: "Animals exhibit variations in any physical or chemical process required to carry out sex-specific activities or to be able to perceive and respond to sex-specific stimuli compared to control." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "sexually_dimorphic_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism_physiology_variant [Term] id: WBPhenotype:0000890 name: larval_pigmentation_variant def: "Larva exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals." [WB:WBPerson557] synonym: "larval_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0001009 ! developmental_pigmentation_variant [Term] id: WBPhenotype:0000891 name: clear_adult def: "Adult animals appear unusually transparent when compared to control." [WB:WBPerson557] synonym: "Clr" BROAD three_letter_name [] is_a: WBPhenotype:0000346 ! adult_pigmentation_variant is_a: WBPhenotype:0001010 ! clear [Term] id: WBPhenotype:0000892 name: hermaphrodite_germline_proliferation_variant def: "Nuclear divisions in the germ line of hermaphrodites are either expanded are reduced compared to control." [WB:WBPerson2021] synonym: "hermaphrodite_germ_cell_proliferation_abnormal" RELATED [] synonym: "hermaphrodite_germ_line_proliferation_abnormal" RELATED [] synonym: "hermaphrodite_germline_proliferation_abnormal" NARROW [] is_a: WBPhenotype:0000823 ! germline_proliferation_variant [Term] id: WBPhenotype:0000893 name: male_germline_proliferation_variant def: "Nuclear divisions in the germ line of male animals are either expanded are reduced compared to control." [WB:WBPerson2021] synonym: "male_germ_cell_proliferation_abnormal" RELATED [] synonym: "male_germ_line_proliferation_abnormal" RELATED [] synonym: "male_germline_proliferation_abnormal" NARROW [] is_a: WBPhenotype:0000823 ! germline_proliferation_variant [Term] id: WBPhenotype:0000894 name: germ_cell_differentiation_variant def: "Variations in the ability of a relatively unspecialized cell to acquire the specialized features of a mature gamete compared to control." [WB:WBPerson2021] synonym: "germ_cell_differentiation_abnormal" NARROW [] relationship: part_of WBPhenotype:0000774 ! gametogenesis_variant [Term] id: WBPhenotype:0000897 name: connective_tissue_variant def: "Variations in the material made up of fibers forming a framework and support structure for body tissues and organs compared to contro" [WB:WBPerson2021, WB:WBPerson557] synonym: "connective_tissue_abnormal" NARROW [] is_a: WBPhenotype:0000200 ! pericellular_component_development_variant [Term] id: WBPhenotype:0000898 name: blast_cell_morphology_variant def: "Any variation in the morphological appearance of blast cells compared to control animals." [WB:cab] synonym: "blast_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000899 name: epithelial_cell_morphology_variant def: "Any variation in the morphological appearance of epithelial cells compared to control animals." [WB:WBPerson557] synonym: "epithelial_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000900 name: germ_cell_morphology_variant def: "Any variation in the morphological appearance of germ cells compared to control animals." [WB:cab] synonym: "germ_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000901 name: gland_cell_morphology_variant def: "Any variation in the morphological appearance of gland cells compared to control animals." [WB:cab] synonym: "gland_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000902 name: intestinal_cell_morphology_variant def: "Any variation in the morphological appearance of intestinal cells compared to control animals." [WB:cab] synonym: "intestinal_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant relationship: part_of WBPhenotype:0000710 ! intestinal_morphology_variant [Term] id: WBPhenotype:0000903 name: marginal_cell_morphology_variant def: "Any variation in the morphological appearance of marginal cells compared to control animals." [WB:cab] synonym: "marginal_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000904 name: muscle_cell_morphology_variant def: "Any variation in the morphological appearance of muscle cells compared to control animals." [WB:cab] synonym: "muscle_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000905 name: neuron_morphology_variant def: "Animals display variations in the structure or organization of components of the neuronal cell internal to the cell itself or in relation to the cellular environment compared to control. A neuron is a major cell type of nervous tissue specialized for transmission of information in the form of patterns of impulses." [WB:cab, WB:WBPerson712] comment: WBbt:0003679 synonym: "neuron_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant relationship: part_of WBPhenotype:0000604 ! nervous_system_morphology_variant [Term] id: WBPhenotype:0000906 name: uterine_vulval_cell_morphology_variant def: "Animals exhibit variations in the form, structure or composition of the epithelial cells that form the interface between the uterus and the vulva (likely via a multilayered set of flaps) compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "uterine_vulval_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0000907 name: anus_morphology_variant def: "Any variation in the structural appearance of the caudal opening of the rectum in the tail compared to control animals." [WB:WBPerson557] synonym: "anus_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_variant [Term] id: WBPhenotype:0000908 name: cloacal_morphology_variant alt_id: WBPhenotype:0000343 def: "Any variation in the structural appearance of\nthe epithelial chamber that links the genital and alimentary tracts to the exterior via the anus (cloacal opening) compared to control animals." [WB:WBPerson557] synonym: "cloaca_morphology_abnormal" EXACT [] synonym: "cloacal_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_variant relationship: part_of WBPhenotype:0000605 ! reproductive_system_morphology_variant [Term] id: WBPhenotype:0000909 name: pharyngeal_intestinal_valve_morphology_variant def: "Any variation in the structure or appearance of the cells that form a narrow passage connecting the posterior bulb of the pharynx to the anterior intestine compared to control. In C. elegans this valve is composed of 3 pairs of cells each forming a flattened disc-like ring and is lined by a layer of cuticle (Wormatlas)." [WB:WBPerson557] synonym: "pharyngeal_intestinal_valve_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000598 ! alimentary_system_morphology_variant [Term] id: WBPhenotype:0000910 name: rectal_morphology_variant def: "Any variation in the morphological appearance of the rectum compared to control animals." [WB:WBPerson557] synonym: "rectal_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000598 ! alimentary_system_morphology_variant [Term] id: WBPhenotype:0000911 name: coelomocyte_morphology_variant def: "Any variation in the morphological appearance of coelomocytes compared to control animals." [WB:WBPerson557] synonym: "coelomocyte_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000599 ! coelomic_system_morphology_variant [Term] id: WBPhenotype:0000912 name: pericellular_component_morphology_variant def: "Any variation in the morphological appearance of pericellular components compared to control animals." [WB:WBPerson557] subset: phenotype_slim_wb synonym: "pericellular_component_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000520 ! morphology_variant [Term] id: WBPhenotype:0000913 name: basal_lamina_morphology_variant def: "Any variation in the morphological appearance of the basal lamina compared to control animals." [WB:WBPerson557] synonym: "basal_lamina_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000600 ! epithelial_system_morphology_variant [Term] id: WBPhenotype:0000914 name: excretory_gland_cell_morphology_variant def: "Animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "excretory_gland_cell_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000601 ! excretory_secretory_system_morphology_variant [Term] id: WBPhenotype:0000915 name: pale_adult def: "Adults show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000346 ! adult_pigmentation_variant is_a: WBPhenotype:0001261 ! pale [Term] id: WBPhenotype:0000916 name: excretory_cell_morphology_variant def: "Any variation in the morphological appearance of the excretory cell compared to control animals." [WB:WBPerson557] synonym: "excretory_canal_cell_morphology_abnormal" RELATED [] synonym: "excretory_cell_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000601 ! excretory_secretory_system_morphology_variant [Term] id: WBPhenotype:0000917 name: excretory_duct_cell_morphology_variant def: "Any variation in the morphological appearance of the excretory duct cell compared to control animals." [WB:WBPerson557] synonym: "excretory_duct_cell_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000601 ! excretory_secretory_system_morphology_variant [Term] id: WBPhenotype:0000918 name: excretory_socket_cell_morphology_variant def: "Any variation in the morphological appearance of the excretory socket cell compared to control animals." [WB:WBPerson557] synonym: "excretory_socket_cell_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000601 ! excretory_secretory_system_morphology_variant [Term] id: WBPhenotype:0000919 name: body_wall_muscle_cell_spindle_development_variant def: "Any variation in the progression of the region of a body wall muscle cell that contains the myofilament lattice (adjacent to the hypodermis) over time, from its initial state to the fully differentiated state compared to control." [WB:WBPaper00000461, WB:WBPerson2021, WB:WBPerson557] synonym: "filament_lattice_body_wall_muscle_cell_development_abnormal" RELATED [] synonym: "spindle_body_wall_muscle_cell_development_abnormal" NARROW [] synonym: "spindle_body_wall_muscle_cell_development_variant" RELATED [] is_a: WBPhenotype:0000087 ! body_wall_cell_development_variant [Term] id: WBPhenotype:0000920 name: body_wall_muscle_cell_development_variant synonym: "body_wall_muscle_cell_development_abnormal" NARROW [] synonym: "muscle_belly_development_abnormal" RELATED [] is_obsolete: true [Term] id: WBPhenotype:0000921 name: striated_muscle_development_variant def: "Variations in the progression of muscle cells that contain fibers that are divided by transverse bands into striations, over time from an initial condition to a later condition compared to control animals." [GO:0055002, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "striated_muscle_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000622 ! muscle_system_development_variant [Term] id: WBPhenotype:0000922 name: male_longitudinal_muscle_development_variant def: "Any variation in the progression of somatic (striated) muscles that run longitudinally in males over time from its initial formation to its mature form compared to control. In C. elegans males have 3 additional sets of sex-specific longitudinal muscles (anterior and posterior outer, anterior and posterior inner, and caudal) that contribute to the body wall musculature (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_longitudinal_muscle_development_abnormal" NARROW [] is_a: WBPhenotype:0000921 ! striated_muscle_development_variant [Term] id: WBPhenotype:0000923 name: nonstriated_muscle_morphology_variant def: "Any variation in the morphological appearance of the nonstriated muscle compared to control animals." [WB:WBPerson557] synonym: "nonstriated_muscle_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000603 ! muscle_system_morphology_variant [Term] id: WBPhenotype:0000924 name: striated_muscle_morphology_variant def: "Any variation in the morphological appearance of the striated muscle compared to control animals." [WB:WBPerson557] synonym: "striated_muscle_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000603 ! muscle_system_morphology_variant [Term] id: WBPhenotype:0000925 name: sex_muscle_morphology_variant def: "Any variation in the morphological appearance of the sex muscles compared to control animals." [WB:WBPerson557] synonym: "sex_muscle_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000923 ! nonstriated_muscle_morphology_variant [Term] id: WBPhenotype:0000926 name: body_wall_muscle_morphology_variant def: "Any variation in the morphological appearance of the body wall muscle compared to control animals." [WB:WBPerson557] synonym: "body_wall_muscle_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000924 ! striated_muscle_morphology_variant [Term] id: WBPhenotype:0000927 name: male_longitudinal_muscle_morphology_variant def: "Any variation in the morphological appearance of the male longitudinal muscle compared to control animals." [WB:WBPerson557] synonym: "male_longitudinal_muscle_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000924 ! striated_muscle_morphology_variant [Term] id: WBPhenotype:0000928 name: male_physiology_variant def: "Animals exhibit variations in any physical or chemical process required to carry out male-specific activities or to be able to perceive and respond to male-specific stimuli compared to control." [WB:WBPerson557] synonym: "male_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000889 ! sexually_dimorphic_physiology_variant [Term] id: WBPhenotype:0000929 name: hermaphrodite_physiology_variant def: "Animals exhibit variations in any physical or chemical process required to carry out hermaphrodite-specific activities or to be able to perceive and respond to hermaphrodite-specific stimuli compared to control." [WB:WBPerson557] synonym: "hermaphrodite_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000889 ! sexually_dimorphic_physiology_variant [Term] id: WBPhenotype:0000930 name: sexually_dimorphic_development_variant def: "Variations in the progression of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "sexually_dimorphic_development_abnormal" NARROW [] is_a: WBPhenotype:0000531 ! organism_development_variant [Term] id: WBPhenotype:0000931 name: bis_phenol_A_response_variant def: "Animals exhibit variations in their response to bis phenol A compared to that observed in control animals." [WB:WBPerson557] synonym: "bis_phenol_A_response_abnormal" NARROW [] is_a: WBPhenotype:0000523 ! chemical_response_variant [Term] id: WBPhenotype:0000932 name: bis_phenol_A_hypersensitive def: "Animals respond to bis phenol A at a lower concentration or a shorter exposure time compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000931 ! bis_phenol_A_response_variant [Term] id: WBPhenotype:0000933 name: MS_lineage_variant def: "The descendants of the MS blastomere exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPaper00002330, WB:WBPerson2021] synonym: "MS_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_variant [Term] id: WBPhenotype:0000934 name: developmental_morphology_variant def: "Animals exhibit variations in the form, structure or composition of any of its parts during a given developmental stage compared to control animals." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "developmental_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000535 ! organism_morphology_variant [Term] id: WBPhenotype:0000935 name: D_lineage_variant def: "The descendants of the D blastomere exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPaper00002572, WB:WBPerson2021] synonym: "D_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_variant [Term] id: WBPhenotype:0000936 name: P4_lineage_variant def: "The descendants of the P4 blastomere exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "P4_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000824 ! embryonic_cell_lineage_variant [Term] id: WBPhenotype:0000937 name: W_lineage_variant def: "The descendants of the W precursor cell exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "W_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000825 ! postembryonic_cell_lineage_variant [Term] id: WBPhenotype:0000938 name: male_V_lineages_variant def: "The descendants of any of the V precursor cells (V1-V6) in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male_V_lineages_abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male_specific_lineage_variant [Term] id: WBPhenotype:0000939 name: male_T_lineages_variant def: "The descendants of TL or TR cells in male animals exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male_T_lineages_abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male_specific_lineage_variant [Term] id: WBPhenotype:0000940 name: male_P_lineages_variant def: "The descendants of any of the P precursor cells (P1-P12) in male animals exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male_P_lineages_abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male_specific_lineage_variant [Term] id: WBPhenotype:0000941 name: male_M_lineage_variant def: "The descendants of the M precursor cell in male animals, exhibit any variation in developmental programs compared to their counterparts in control animals." [WB:WBPerson2021] synonym: "male_M_lineage_abnormal" NARROW [] is_a: WBPhenotype:0000809 ! male_specific_lineage_variant [Term] id: WBPhenotype:0000942 name: accessory_cell_development_variant def: "Any variation in the progression of an accessory cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. An accessory cell supports sensory neurons." [WB:WBPerson2021] synonym: "accessory_cell_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000623 ! nervous_system_development_variant [Term] id: WBPhenotype:0000943 name: ganglion_development_variant def: "Any variation in the progression of a cluster of neuron cell bodies (somata) over time from its initial formation to its mature form compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "ganglion_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000623 ! nervous_system_development_variant [Term] id: WBPhenotype:0000944 name: neurite_development_variant def: "Variations in the progression of a neuronal extension (such as axons or dendrites) over time, from its formation to the mature structure compared to control." [GO:0031175, WB:WBPerson2021] synonym: "neurite_development_abnormal" NARROW [] is_a: WBPhenotype:0000816 ! neuron_development_variant [Term] id: WBPhenotype:0000945 name: neuropil_development_variant def: "Any variation in the progression of a dense feltwork of interwoven cytoplasmic processes of nerve cells (dendrites and axons) and support cells, over time from an initial condition to a later condition, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuropil_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000623 ! nervous_system_development_variant [Term] id: WBPhenotype:0000946 name: pharyngeal_nervous_system_development_variant def: "Variations in the progression of a set of interacting or interdependent entities forming the pharyngeal nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses." [GO:0007420, WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal_nervous_system_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000623 ! nervous_system_development_variant [Term] id: WBPhenotype:0000947 name: connective_tissue_morphology_variant def: "Variations in the form, structure or composition of the material made up of fibers forming a framework and support structure for body tissues and organs compared to control. " [WB:WBPerson2021, WB:WBPerson557] synonym: "connective_tissue_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000912 ! pericellular_component_morphology_variant [Term] id: WBPhenotype:0000948 name: cuticle_morphology_variant def: "Any variation in the appearance or structure of the rigid external coating which is secreted by the hypodermis, seam and some interfacial epithelial cells compared to control (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "cuticle_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000912 ! pericellular_component_morphology_variant [Term] id: WBPhenotype:0000949 name: pseudocoelom_morphology_variant def: "Any variation in the appearance of the body cavity compared to control. In C. elegans , an aberrancy in the psedocoelom can involve an accumulation of fluids or fluorescent reporters." [WB:WBPerson712] synonym: "pseudocoelom_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000912 ! pericellular_component_morphology_variant [Term] id: WBPhenotype:0000950 name: neuronal_sheath_cell_development_variant def: "Any variation in the progression of a neuronal sheath cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control. A neuronal sheath cell is a structural cell that forms a specialized environment surrounding the sensory endings of a neuron." [WB:WBPerson2021] synonym: "neuronal_sheath_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000942 ! accessory_cell_development_variant [Term] id: WBPhenotype:0000951 name: socket_cell_development_variant def: "Any variation in the progression of a socket cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell compared to control." [WB:WBPerson2021] synonym: "socket_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000942 ! accessory_cell_development_variant [Term] id: WBPhenotype:0000952 name: anterior_ganglion_development_variant def: "Any variation in the progression of a cluster of neuron somata located close to the nerve ring over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "anterior_ganglion_development_abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion_development_variant [Term] id: WBPhenotype:0000953 name: dorsal_ganglion_development_variant def: "Any variation in the progression of the ganglion that lies dorsally beside the nerve ring in the head over time from its initial formation to its mature form compared to control. In C. elegans, It contains neuron cell bodies that send their neuronal processes into the ring and longitudinal nerves, but form no local neuropil separate from the nerve ring. The dorsal ganglion is in close contact with the dorsal hypodermal cord (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dorsal_ganglion_development_abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion_development_variant [Term] id: WBPhenotype:0000954 name: dorsorectal_ganglia_development_variant def: "Any variation in the progression of the ganglion which lies above and behind the rectum in the tail, in close continuity with the anal hypodermal ridge over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dorsorectal_ganglia_development_abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion_development_variant [Term] id: WBPhenotype:0000955 name: lateral_ganglia_development_variant def: "Any variation in the progression of the left and right lateral ganglia which lie beside the nerve ring in the head over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "lateral_ganglia_development_abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion_development_variant [Term] id: WBPhenotype:0000956 name: lumbar_ganglia_development_variant def: "Any variation in the progression of the left and right lumbar ganglia which lie behind the pre-anal ganglion in the tail, in lateral positions over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "lumbar_ganglia_development_abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion_development_variant [Term] id: WBPhenotype:0000957 name: posterior_lateral_ganglion_development_variant def: "Any variation in the progression of the neuron somata associated with the post-deirid over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior_lateral_ganglion_development_abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion_development_variant [Term] id: WBPhenotype:0000958 name: preanal_ganglion_development_variant def: "Any variation in the progression of the ganglion which lies at the posterior limit of the ventral nerve cord in the tail over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "preanal_ganglion_development_abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion_development_variant [Term] id: WBPhenotype:0000959 name: retrovesicular_ganglion_development_variant def: "Any variation in the progression of the ganglion which lies at the anterior limit of the ventral nerve cord, near the ventral ganglion and nerve ring in the head posterior to the excretory pore over time from its initial formation to its mature form compared to control (Wormatlas" [WB:WBPerson2021, WB:WBPerson557] synonym: "retrovesicular_ganglion_development_abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion_development_variant [Term] id: WBPhenotype:0000960 name: ventral_ganglion_development_variant def: "Any variation in the progression of the ganglion which lies ventrally beside the nerve ring in the head, just anterior of the retrovesicular ganglion over time from its initial formation to its mature form compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "ventral_ganglion_development_abnormal" NARROW [] is_a: WBPhenotype:0000943 ! ganglion_development_variant [Term] id: WBPhenotype:0000961 name: pattern_of_transgene_expression_variant def: "Any variation in the cellular or subcellular pattern of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] synonym: "pattern_of_transgene_expression_abnormal" NARROW [] is_a: WBPhenotype:0000306 ! transgene_expression_variant [Term] id: WBPhenotype:0000962 name: level_of_transgene_expression_variant def: "Any variation in the measured expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] synonym: "level_of_transgene_expression_abnormal" NARROW [] is_a: WBPhenotype:0000306 ! transgene_expression_variant [Term] id: WBPhenotype:0000963 name: male_pigmentation_variant def: "Males exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the organism compared to control animals." [WB:WBPerson557] synonym: "male_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000527 ! organism_pigmentation_variant [Term] id: WBPhenotype:0000964 name: DMPP_resistant def: "Animals fail to respond to the concentration of DMPP that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000681 ! DMPP_response_variant [Term] id: WBPhenotype:0000965 name: somatic_cell_death_variant def: "Animals exhibit variations in the programmed cell death pathway that is triggered in cells other than germ cells and that is not subject to upstream checkpoint regulation." [WB:WBPaper00032243, WB:WBPerson712] synonym: "somatic_cell_death_abnormal" NARROW [] is_a: WBPhenotype:0001172 ! programmed_cell_death_variant [Term] id: WBPhenotype:0000966 name: germline_mortal def: "Progressive decrease in brood size culminating, over generations, in the loss of reproductive ability and thus becoming effectively sterile." [WB:WBPaper00003886, WB:WBPaper00027026, WB:WBPerson712] synonym: "Mrt" BROAD three_letter_name [] is_a: WBPhenotype:0000987 ! germ_cell_physiology_variant [Term] id: WBPhenotype:0000968 name: tail_spike_variant def: "Any variation in the structure or appearance of the thin cuticle specialization found at the extreme posterior end of the tail compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000073 ! tail_morphology_variant [Term] id: WBPhenotype:0000969 name: accessory_cell_morphology_variant def: "Animals exhibit variations in the structure, organization or placement of the cells that support sensory neurons, compared to that observed in control animals. In C. elegans, this category collectively refers to socket cells, sheath cells, and structural cells, or their processes." [WB:WBPerson712] comment: WBbt:0005762 synonym: "accessory_cell_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000604 ! nervous_system_morphology_variant [Term] id: WBPhenotype:0000970 name: embryonic_pigmentation_variant def: "Embryos exhibit variations in the accumulation or expression of biochromes or any other substances that alter its transparency/translucency compared to control animals ." [WB:WBPerson557] synonym: "embryonic_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0001009 ! developmental_pigmentation_variant [Term] id: WBPhenotype:0000971 name: anterior_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of the anterior body axis compared to control." [WB:WBPerson557] synonym: "anterior_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000786 ! body_axis_pigmentation_variant [Term] id: WBPhenotype:0000972 name: neuronal_sheath_cell_morphology_variant def: "Animals exhibit variations in the structure or composition of the glia-like support cell of neuronal sensilla that ensheathes the dendrite tips and or processes of neurons, from that observed in control animals. In C. elegans, sheath cells have highly invaginated and vesiculated surfaces, which provide a specialized environment for dendritic structures." [WB:WBPaper00000822, WB:WBPaper00000938, WB:WBPerson712] synonym: "neuronal_sheath_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000969 ! accessory_cell_morphology_variant [Term] id: WBPhenotype:0000973 name: homologous_recombination_increased def: "Animals exhibit an increased frequency of exchange of genetic material between non-sister chromatids of a pair of homologues. " [GO:0007131, WB:WBPerson712] is_a: WBPhenotype:0000742 ! DNA_recombination_variant [Term] id: WBPhenotype:0000974 name: accessory_cell_physiology_variant def: "Animals exhibit variations in any physical or chemical process required by a subset of interfacial cells to carry out its normal function or be able to perceive and respond to stimuli, compared to control. It can refer to socket cells, sheath cells and structural cells or their processes (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "accessory_cell_physiology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000612 ! nervous_system_physiology_variant [Term] id: WBPhenotype:0000975 name: neuronal_sheath_cell_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for a neuronal sheath cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557] synonym: "neuronal_sheath_cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000974 ! accessory_cell_physiology_variant [Term] id: WBPhenotype:0000976 name: ventral_cord_patterning_variant def: "Any variation in the developmental process that results in the creation of defined areas or spaces within the ventral cord to which cells respond and eventually are instructed to differentiate compared to control." [GO:0007389, WB:WBPerson2021, WB:WBPerson557] synonym: "ventral_cord_patterning_abnormal" NARROW [] is_a: WBPhenotype:0000515 ! ventral_nerve_cord_development_variant [Term] id: WBPhenotype:0000977 name: somatic_gonad_morphology_variant def: "Animals exhibit variations in the form, structure or composition of the components of the gonad that are separate from the germline proper compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "somatic_gonad_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0001355 ! gonad_morphology_variant [Term] id: WBPhenotype:0000978 name: spermatheca_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the spermatheca to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "spermatheca_physiology_abnormal" NARROW [] is_a: WBPhenotype:0001197 ! somatic_gonad_physiology_variant [Term] id: WBPhenotype:0000979 name: spermatheca_dilation_defective def: "Animals exhibit defects in any physical or chemical process involved in the dilation of the distal spermatheca which is required for the oocyte exit from the gonad arm." [WB:WBPaper00003371, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000978 ! spermatheca_physiology_variant [Term] id: WBPhenotype:0000980 name: pharyngeal_contraction_variant def: "Any variation in the muscle contractions that control feeding compared to control. Contractions are necessary for bacterial uptake from the surrounding environment." [WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal_contraction_abnormal" NARROW [] is_a: WBPhenotype:0000634 ! pharyngeal_pumping_variant [Term] id: WBPhenotype:0000981 name: spermatocyte_meiosis_variant alt_id: WBPhenotype:0000713 def: "Animals exhibit variations in the meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids (non-motile sperm) compared to control." [GO:0048137, WB:WBPaper00027300, WB:WBPerson2021] synonym: "spermatocyte_division_abnormal" NARROW [] synonym: "spermatocyte_division_variant" EXACT [] synonym: "spermatocyte_meiosis_abnormal" NARROW [] is_a: WBPhenotype:0000670 ! spermatogenesis_variant [Term] id: WBPhenotype:0000982 name: spermatid_maturation_variant def: " Animals exhibit variations in the ability of a relatively unspecialized spermatocyte to acquire the properties of a spermatid cell compared to control." [WB:WBPaper00027300, WB:WBPerson2021] synonym: "spermatid_maturation_abnormal" NARROW [] is_a: WBPhenotype:0000670 ! spermatogenesis_variant [Term] id: WBPhenotype:0000983 name: fertilization_defective def: "Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) during sexual reproduction." [GO:0009566, WB:WBPerson2021] is_a: WBPhenotype:0000613 ! reproductive_system_physiology_variant [Term] id: WBPhenotype:0000984 name: posterior_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency of the posterior body axis compared to control." [WB:WBPerson557] synonym: "posterior_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000786 ! body_axis_pigmentation_variant [Term] id: WBPhenotype:0000985 name: blast_cell_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the blast cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "blast_cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000986 name: epithelial_cell_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the epithelial cell to carry out its normal functions or activities, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "epithelial_cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000987 name: germ_cell_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the germ cell to carry out its normal functions or activities or be able to perceive and respond to cues, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "germ_cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000988 name: gland_cell_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the gland cell to carry out its normal functions or activities or be able to perceive and respond to signals, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "gland_cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000989 name: marginal_cell_physiology_variant def: "Animals exhibit deviations at the cellular level, but not necessarily restricted to a single cell, in any physical or chemical process required for a marginal cell to carry out its normal function and activities or be able to perceive and respond to stimuli." [GO:0009987, WB:WBPerson557] synonym: "marginal_cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000990 name: muscle_cell_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the muscle cell to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "muscle_cell_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000991 name: neuron_physiology_variant def: "Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes." [WB:WBPaper00032221, WB:WBPerson712] synonym: "neuron_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0000992 name: high_sodium_chloride_concentration_osmotic_avoidance_defective def: "Failure to execute the characteristic response to high concentrations of sodium chloride solution. C. elegans typically avoids high concentrations of sodium chloride solution." [WB:WBPerson2021] is_a: WBPhenotype:0001453 ! high_sodium_chloride_concentration_osmotic_avoidance_variant [Term] id: WBPhenotype:0000993 name: anal_depressor_contraction_defect def: " Animals fail to contract the anal depressor muscle." [WB:WBPaper00001256] synonym: "Exp" BROAD three_letter_name [] is_a: WBPhenotype:0001092 ! larval_defecation_defect [Term] id: WBPhenotype:0000994 name: intestinal_contractions_variant def: "Any variations in the contraction of the enteric muscles that are involved in defecation motor program compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emc" RELATED [] synonym: "enteric muscle contraction variant" RELATED [] synonym: "intestinal_contractions_abnormal" NARROW [] is_a: WBPhenotype:0000210 ! defecation_contraction_variant [Term] id: WBPhenotype:0000996 name: expulsion_defective def: "Animals exhibit defects in the expulsion of gut contents. In C. elegans, this refers to the final step of the defecation cycle in which the intestinal muscle and anal depressor contractions further pressurize intestinal contents and open the anus to permit expulsion." [WB:WBPaper00001256, WB:WBPaper00031246, WB:WBPerson712] synonym: "Emc" BROAD three_letter_name [] synonym: "Exp" BROAD three_letter_name [] is_a: WBPhenotype:0000205 ! expulsion_variant [Term] id: WBPhenotype:0000997 name: cryophilic def: "Animals tend to track and stay within low temperature environments." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000478 ! isothermal_tracking_behavior_variant [Term] id: WBPhenotype:0000998 name: thermophilic def: "Animals tend to track and stay within high temperature environments." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000478 ! isothermal_tracking_behavior_variant [Term] id: WBPhenotype:0000999 name: athermotactic def: "The responses of an animal towards temperature are not influenced by its cultivation temperature." [WB:WBPerson363] is_a: WBPhenotype:0000478 ! isothermal_tracking_behavior_variant [Term] id: WBPhenotype:0001000 name: developmental_behavior_variant def: "Any variation in the behavior characteristic during certain developmental stage(s) compared to control." [WB:cab] subset: phenotype_slim_wb synonym: "developmental_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0001001 name: dauer_behavior_variant def: "Variations in the specific actions or reactions of dauer stage animals in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000819 ! postembryonic_behavior_variant [Term] id: WBPhenotype:0001002 name: head_muscle_behavior_variant def: "Variations in the specific actions or reactions of the head muscles in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "head_muscle_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000595 ! head_behavior_variant [Term] id: WBPhenotype:0001003 name: L4_lethal def: "Animals die at the L4 stage of the life cycle." [WB:WBPerson2021] synonym: "Let" BROAD [] synonym: "Lvl" BROAD three_letter_name [] is_a: WBPhenotype:0000058 ! late_larval_lethal [Term] id: WBPhenotype:0001004 name: pharyngeal_relaxation_variant def: "Any variation in the relaxation of pharyngeal muscles after contraction events compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "pharyngeal_relaxation_abnormal" NARROW [] is_a: WBPhenotype:0000634 ! pharyngeal_pumping_variant [Term] id: WBPhenotype:0001005 name: backward_locomotion_variant def: "Variations in the spontaneous or induced backward crawling locomotion of an animal compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "backward_locomotion_abnormal" NARROW [] is_a: WBPhenotype:0004017 ! locomotor_coordination_variant [Term] id: WBPhenotype:0001006 name: pharyngeal_pumping_rate_variant def: "The number of coordinated contraction-relaxation cycles (pumps) exhibited by the pharyngeal muscle deviates from that observed for control animals." [WB:WBPaper00001709, WB:WBPerson712] synonym: "feeding_rate_dynamics_abnormal" RELATED [] synonym: "pharyngeal_pumping_rate_abnormal" NARROW [] synonym: "pumping_rate_dynamics_abnormal" RELATED [] is_a: WBPhenotype:0000634 ! pharyngeal_pumping_variant [Term] id: WBPhenotype:0001007 name: other_abnormality_early_emb def: "Unclassified abnormality in the inviable one- to four-cell embryo." [WB:cab] synonym: "Emb" BROAD three_letter_name [] synonym: "Oth" RELATED [] synonym: "other_abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001008 name: male_nervous_system_development_variant def: "Variations in the progression of a set of interacting or interdependent entities forming the male nervous system over time from an initial condition to a later condition compared to control animals. The nervous system is involved in the coordination and control of bodily activities and the interpretation of information from the senses." [GO:0007420, WB:WBPerson2021, WB:WBPerson557] synonym: "male_nervous_system_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0000623 ! nervous_system_development_variant [Term] id: WBPhenotype:0001009 name: developmental_pigmentation_variant def: "Animals exhibit variations in the accumulation or expression of biochromes or any other substances that alter transparency/translucency of a particular developmental stage of the amimal compared to control animals." [WB:WBPerson557] synonym: "developmental_pigmentation_abnormal" NARROW [] is_a: WBPhenotype:0000527 ! organism_pigmentation_variant [Term] id: WBPhenotype:0001010 name: clear def: "Animals appear unusually transparent when compared to control." [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654] synonym: "Clr" BROAD three_letter_name [] is_a: WBPhenotype:0000527 ! organism_pigmentation_variant [Term] id: WBPhenotype:0001011 name: complex_phenotype_early_emb def: " Population of unhatched eggs exhibit a complex combination of defects that do not match other class definitions." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001007 ! other_abnormality_early_emb [Term] id: WBPhenotype:0001012 name: organism_pathogen_response_variant def: "Animals exhibit variations in their response to disease causing agents, compared to control. Pathogen response includes prevention, damage control and recovery from the infection caused by the attack" [GO:0006952, WB:WBPaper00032196, WB:WBPerson2021, WB:WBPerson712] synonym: "bacterial_load_variant " NARROW [] synonym: "organism_pathogen_response_abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0001013 name: pathogen_susceptibility_increased def: "Animals are more prone to infection compared to control." [WB:cab, WB:WBPaper00005370, WB:WBPaper00024299] synonym: "enhanced_susceptibility_to_pathogens" RELATED [] synonym: "Esp" BROAD three_letter_name [] is_a: WBPhenotype:0001012 ! organism_pathogen_response_variant [Term] id: WBPhenotype:0001014 name: pathogen_resistance_increased def: "Animals are less prone to infection compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001012 ! organism_pathogen_response_variant [Term] id: WBPhenotype:0001015 name: developmental_growth_variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during any development stages compared to control animals.\n" [WB:WBPerson2021, WB:WBPerson557] synonym: "developmental_growth_abnormal" NARROW [] is_a: WBPhenotype:0000030 ! growth_variant [Term] id: WBPhenotype:0001016 name: larval_growth_variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the larval stages compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "larval_growth_abnormal" NARROW [] is_a: WBPhenotype:0001015 ! developmental_growth_variant [Term] id: WBPhenotype:0001017 name: adult_growth_variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the adult stage compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "adult_growth_abnormal" NARROW [] is_a: WBPhenotype:0001015 ! developmental_growth_variant [Term] id: WBPhenotype:0001018 name: cytokinesis_variant_emb def: "Any variation that disrupts the cytoplasmic division of a cell during embryonic development compared to control." [GO:0000910, WB:WBPerson2021] synonym: "Cyk" BROAD three_letter_name [] synonym: "cytokinesis_abnormal" NARROW [] is_a: WBPhenotype:0000050 ! embryonic_lethal is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0001019 name: mid_larval_arrest def: "Animals arrest during the stage between early and late larval development. In C. elegans, mid larval arrest occurs during the L2 to L3 stages of development." [WB:cab] is_a: WBPhenotype:0000059 ! larval_arrest [Term] id: WBPhenotype:0001020 name: embryonic_lethal_late_emb def: " Animals die during the final stages of embryogenesis. In C. elegans, this lethality refers to death during the last (3-fold) stage of embryogenesis, which normally occurs 620-800 min after the first cleavage at 20C, the stage after elongation." [WB:WBPerson101] synonym: "Emb" BROAD three_letter_name [] synonym: "Led" RELATED [] is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0001021 name: male_sexual_development_variant def: "Genetically male animals exhibit deviations in the sexual program specific to males. In C. elegans, this often refers to XO animals being transformed into fertile hermaphrodites." [WB:WBPaper00000498, WB:WBPerson2021] synonym: "Her" BROAD three_letter_name [] synonym: "male_sexual_development_abnormal" NARROW [] is_a: WBPhenotype:0000822 ! sex_determination_variant [Term] id: WBPhenotype:0001022 name: hermaphrodite_sexual_development_variant def: "Genetically hermaphrodite animals exhibit deviations in the sexual program specific to hermaphrodites. In C. elegans, this refers to XX animals that develop as males or intersexuals instead of self-fertile hermaphrodites." [WB:WBPerson2021] synonym: "hermaphrodite_sexual_development_abnormal" NARROW [] is_a: WBPhenotype:0000822 ! sex_determination_variant [Term] id: WBPhenotype:0001023 name: sexually_dimorphic_morphology_variant def: "Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as one sex or the other in the population, from that observed for control animals." [GO:0009886, WB:WBPerson712] subset: phenotype_slim_wb synonym: "sexually_dimorphic_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000535 ! organism_morphology_variant [Term] id: WBPhenotype:0001024 name: male_morphology_variant def: "Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a male in the population, from that observed for control males." [GO:0009886, WB:WBPerson712] synonym: "male_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001023 ! sexually_dimorphic_morphology_variant [Term] id: WBPhenotype:0001025 name: hermaphrodite_morphology_variant def: "Animals exhibit variations in the outcome of morphogenic processes required for formation or proper placement of sex-specific structures that distinguish the animal as a hermaphrodite in the population, from that observed for control hermaphrodites." [GO:0009886, WB:WBPerson712] synonym: "hermaphrodite_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001023 ! sexually_dimorphic_morphology_variant [Term] id: WBPhenotype:0001026 name: nuclear_morphology_variation_early_emb def: "Animals exhibit variations in the form, structure or composition of the membrane enclosed organelle which contains most of the cell's genetic material during the early embryonic stage compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Nmo" BROAD three_letter_name [] is_a: WBPhenotype:0001035 ! nuclear_appearance_number_defective_early_emb [Term] id: WBPhenotype:0001027 name: nuclear_position_defective_early_emb def: "Embryos show defects in the placement of the nucleus to a specific location within the cell." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Npo" BROAD three_letter_name [] synonym: "nuclear_position_abnormal" NARROW [] is_a: WBPhenotype:0001138 ! nucleus_defective_early_emb [Term] id: WBPhenotype:0001028 name: nuclear_appearance_variant def: "The morphological appearance of nuclei differs from control animals." [WB:cab] subset: phenotype_slim_wb synonym: "nuclear_appearance_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0001029 name: patchy_coloration def: "Animals exhibit an uneven distribution of biochromes or any other substances that cause disparate transparency/translucency compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "Pch" BROAD three_letter_name [] is_a: WBPhenotype:0000527 ! organism_pigmentation_variant [Term] id: WBPhenotype:0001030 name: pronuclear_envelope_defective_early_emb def: "Any deficiency in the lipid bilayer, the equivalent of the nuclear envelope, that surrounds each pronucleus within gametes and within the early zygote after pronuclear reformation (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Pna" BROAD three_letter_name [] synonym: "pronuclear_envelope_abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_defective_early_emb [Term] id: WBPhenotype:0001031 name: pronuclear_migration_reduced_early_emb def: "Any variation in the movement/fusion of pronuclei in the fertilized oocyte compared to control. For example, lack of male pronuclear migration, female pronuclear migration variable, sometimes multiple female pronuclei, no or small spindle." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001152 ! pronuclear_migration_defective_early_emb [Term] id: WBPhenotype:0001032 name: larval_behavior_variant def: "Variations in the specific actions or reactions of a larvae in response to external or internal stimuli compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "larval_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000819 ! postembryonic_behavior_variant [Term] id: WBPhenotype:0001033 name: proximal_germ_cell_proliferation_variant def: " Any variation in the spatial pattern of proliferation and differentiation in the germ line compared to control. In C. elegans, this refers to an ectopic mass of proliferating germ cells that occupies the proximal adult germ line, a region normally occupied by gametes." [WB:WBPaper00006484, WB:WBPerson2021] synonym: "Pro" BROAD three_letter_name [] synonym: "proximal_germ_cell_proliferation_abnormal" NARROW [] is_a: WBPhenotype:0001215 ! germ_cell_mitosis_variant [Term] id: WBPhenotype:0001034 name: pronuclear_nuclear_appearance_defective_early_emb def: " The morphology of pronuclei and nuclei are defective in the early embryo. In C. elegans, this defect is often characterized by pronuclei and nuclei that are small or missing altogether and are often accompanied by spindle defects." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] synonym: "pronuclear_nuclear_appearance_abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal is_a: WBPhenotype:0001374 ! pronuclear_nuclear_appearance_variant_emb [Term] id: WBPhenotype:0001035 name: nuclear_appearance_number_defective_early_emb def: "The size, number and organization of the components of the nuclei in the early embryo deviate from control . In C. elegans, this is characterized by nuclei that are completely missing or are significantly smaller than normal; often accompanied by spindle and cytokinesis defects." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] synonym: "nuclear_appearance_number_abnormal" NARROW [] synonym: "nucleus_abnormal_emb" RELATED [] is_a: WBPhenotype:0000770 ! embryonic_cell_morphology_variant is_a: WBPhenotype:0001138 ! nucleus_defective_early_emb [Term] id: WBPhenotype:0001036 name: sterile_F1 def: "Any variation that compromises the reproductive ability of an F1 generation animal." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001037 ! sterile_progeny [Term] id: WBPhenotype:0001037 name: sterile_progeny def: "Any variation that compromises the reproductive ability of the progeny of an animal." [WB:WBPerson2021, WB:WBPerson557] synonym: "Stp" BROAD three_letter_name [] is_a: WBPhenotype:0000069 ! progeny_variant is_a: WBPhenotype:0000688 ! sterile [Term] id: WBPhenotype:0001038 name: tumorous_germline def: "Germ cells do not exit the mitotic cycle, resulting in a expansion of the unspecialized germ cell population compared to control." [WB:WBPaper00002730, WB:WBPerson2021] synonym: "Tum" BROAD three_letter_name [] synonym: "tumorous_germ_line" EXACT [] is_a: WBPhenotype:0000812 ! germ_cell_development_variant [Term] id: WBPhenotype:0001039 name: embryonic_growth_variant def: "Variations in the processes that regulate the change (increase) in size or mass of an integrated living unit (a cell, tissue, organ or organism) during the embryonic stage compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "embryonic_growth_abnormal" NARROW [] is_a: WBPhenotype:0001015 ! developmental_growth_variant [Term] id: WBPhenotype:0001040 name: chemosensory_response_variant def: "Variations in the state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus, compared to control." [GO:0042221, WB:cab, WB:cgc3824, WB:WBPerson2021] synonym: "chemosensory_response_abnormal" NARROW [] is_a: WBPhenotype:0000523 ! chemical_response_variant is_a: WBPhenotype:0001049 ! chemosensory_behavior_variant [Term] id: WBPhenotype:0001041 name: meiosis_defective_early_emb def: "Animals exhibit defects in the progression of meiosis which ultimately result in embryonic lethality." [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD [] synonym: "Mei" BROAD three_letter_name [] synonym: "meiosis_abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001042 name: neuron_function_reduced def: "Neurons show impaired ability in the detection, transmission, coordination or their response to information about an animal's internal and external environments." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000991 ! neuron_physiology_variant [Term] id: WBPhenotype:0001043 name: interphase_entry_defective_early_emb def: "Embryos do not enter or take longer to enter first interphase compared to control." [WB:cab, WB:cgc7141] synonym: "Emb" BROAD three_letter_name [] synonym: "interphase_entry_abnormal" NARROW [] is_a: WBPhenotype:0000740 ! cell_cycle_variant is_a: WBPhenotype:0000775 ! meiosis_variant is_a: WBPhenotype:0001041 ! meiosis_defective_early_emb [Term] id: WBPhenotype:0001044 name: cortical_dynamics_defective_early_emb def: "little/no cortical ruffling or pseudocleavage furrow, or excessive cortical activity. In C. elegans, this is often characterized at the two-cell stage." [WB:cab, WB:cgc7141] synonym: "cortical_dynamics_abnormal" NARROW [] synonym: "Cpa" BROAD [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000764 ! embryonic_cell_organization_biogenesis_variant is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001045 name: sporadic_pumping def: "Pharyngeal pumping contractions are brief and occur arhythmically in response to stimulus compared to control." [WB:WBPaper00001709] is_a: WBPhenotype:0000019 ! pharyngeal_pumping_reduced [Term] id: WBPhenotype:0001046 name: pharyngeal_muscle_morphology_variant def: "Any variations associated with the characteristic morphology of the pharyngeal muscle such as shape, birefringence etc compared to control." [WB:WBPaper00001709] synonym: "pharyngeal_muscle_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000923 ! nonstriated_muscle_morphology_variant [Term] id: WBPhenotype:0001047 name: aqueous_positive_chemotaxis_variant def: "Animals exhibit variations in the movement towards typically attractive water-soluble chemicals compared to control." [WB:cab, WB:cgc3824] synonym: "aqueous_positive_chemotaxis_abnormal" NARROW [] synonym: "water_soluble_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000635 ! positive_chemotaxis_variant is_a: WBPhenotype:0001443 ! aqueous_chemosensory_response_variant [Term] id: WBPhenotype:0001048 name: odorant_chemosensory_response_variant def: "Animals exhibit variations in the chemosensory response to volatile organic compounds compared to control." [WB:WBPerson2021] synonym: "odorant_chemosensory_response_abnormal" NARROW [] synonym: "volatile_chemosensory_response_abnormal" RELATED [] is_a: WBPhenotype:0001040 ! chemosensory_response_variant [Term] id: WBPhenotype:0001049 name: chemosensory_behavior_variant def: "Variations in behavior that is dependent upon the sensation of chemicals, compared to control." [GO:0007635, WB:WBPerson2021] subset: phenotype_slim_wb synonym: "chemosensory_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0001050 name: chemosensation_variant def: "Animals exhibit variations in any of a series of events in which an organism receives a sensory chemical stimulus, converts it to a molecular signal, and recognizes and characterizes the signal, compared to control." [GO:0007606, WB:WBPerson2021] synonym: "chemosensation_abnormal" NARROW [] is_a: WBPhenotype:0001049 ! chemosensory_behavior_variant [Term] id: WBPhenotype:0001051 name: cation_positive_chemotaxis_variant def: "Animals exhibit variations in the characteristic movement towards typically attractive cations compared to control." [WB:cab, WB:cgc387, WB:WBPaper00000387] synonym: "cation_positive_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_variant [Term] id: WBPhenotype:0001052 name: anion_positive_chemotaxis_variant def: "Animals exhibit variations in the characteristic movement towards typically attractive anions compared to control." [WB:cab, WB:cgc387, WB:WBPaper00000387] synonym: "anion_positive_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_variant [Term] id: WBPhenotype:0001053 name: cyclic_nucleotide_positive_chemotaxis_variant def: "Animals exhibit variations in the characteristic movement towards cyclic nucleotides compared to control." [WB:cab, WB:cgc387] synonym: "cyclic_nucleotide_positive_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_variant [Term] id: WBPhenotype:0001054 name: cGMP_chemotaxis_defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to cGMP. In C. elegans, this is characterized by the failure to move towards cGMP." [WB:cab, WB:cgc387, WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001464 ! cGMP_chemotaxis_variant [Term] id: WBPhenotype:0001055 name: bromide_chemotaxis_defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to bromide. In C. elegans, this is characterized by the failure to move towards bromide." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001439 ! anion_positive_chemotaxis_defective is_a: WBPhenotype:0001457 ! bromide_chemotaxis_variant [Term] id: WBPhenotype:0001056 name: iodide_chemotaxis_defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to iodide. In C. elegans, this is characterized by the failure to move towards iodide." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001439 ! anion_positive_chemotaxis_defective is_a: WBPhenotype:0001459 ! iodide_chemotaxis_variant [Term] id: WBPhenotype:0001057 name: lithium_chemotaxis_defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to lithium. In C. elegans, this is characterized by the failure to move towards lithium." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001440 ! cation_positive_chemotaxis_defective [Term] id: WBPhenotype:0001058 name: potassium_chemotaxis_defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to potassium. In C. elegans, this is characterized by the failure of the animals to move towards potassium." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001440 ! cation_positive_chemotaxis_defective [Term] id: WBPhenotype:0001059 name: magnesium_chemotaxis_defective def: "Animals fail to exhibit the same taxis behavior as control animals in response to magnesium. In C. elegans, this is characterized by the failure to move towards magnesium." [WB:cab, WB:cgc387] is_a: WBPhenotype:0001440 ! cation_positive_chemotaxis_defective [Term] id: WBPhenotype:0001060 name: AWC_odorant_chemotaxis_defective def: "In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWC compared to control." [WB:WBPerson2021] synonym: "AWC_volatile_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective [Term] id: WBPhenotype:0001061 name: AWA_odorant_chemotaxis_defective def: "In C. elegans, this is characterized by the failure to move towards typically attractive volatile organic molecules sensed by the AWA compared to control." [WB:WBPerson2021] synonym: "AWA_volatile_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective [Term] id: WBPhenotype:0001062 name: late_paralysis_arrested_elongation_two_fold def: "In C. elegans, movement and elongation stop nearly simultaneously soon after the twofold stage of elongation. However, mutant embryos twitch at the one-and-a-half-fold stage of elongation, like control animals, and move as well as control animals at the two- fold stage. " [WB:cab, WB:cgc1894] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0001063 name: egg_laying_phases_variant def: "Fluctuation pattern between inactive, active, and egg-laying states is atypical, based on the analysis of the distribution of the log intervals of egg-laying events compared to control." [pmid:10757762, pmid:9697864, WB:cab] synonym: "egg_laying_phases_abnormal" NARROW [] is_a: WBPhenotype:0000272 ! egg_laying_irregular [Term] id: WBPhenotype:0001064 name: inactive_phase_long def: "Animals display uncharacteristically long periods during which they do not lay eggs compared to control, usually based on the analysis of the distribution of the log intervals of egg-laying events. In C. elegans, long inactive phases can be observed in HSN-ablated and serotonin-deficient animals" [pmid:10757762, pmid:9697864, WB:cab] is_a: WBPhenotype:0000006 ! egg_laying_defective is_a: WBPhenotype:0001066 ! inactive_phase_variant [Term] id: WBPhenotype:0001065 name: fewer_egg_laying_events_during_active def: "Fewer egg-laying events occur within the active phase of egg laying, based on the analysis of the distribution of the log intervals of egg-laying events, compared to control." [pmid:9697864, WB:cab] is_a: WBPhenotype:0000006 ! egg_laying_defective is_a: WBPhenotype:0001067 ! active_phase_variant [Term] id: WBPhenotype:0001066 name: inactive_phase_variant def: "The period during which the animal is less likely to lay eggs is not typical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab] synonym: "inactive_phase_abnormal" NARROW [] is_a: WBPhenotype:0001063 ! egg_laying_phases_variant [Term] id: WBPhenotype:0001067 name: active_phase_variant def: "The active phase of egg-laying, the period during which animals are more likely to display multiple egg-laying events, is atypical compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] synonym: "active_phase_abnormal" NARROW [] is_a: WBPhenotype:0001063 ! egg_laying_phases_variant [Term] id: WBPhenotype:0001068 name: egg_laying_serotonin_resistant def: "Animals are not induced to lay eggs in reponse to exogenous serotonin. Serotonin stimulates egg-laying in C. elegans." [WB:WBPaper00000635, WB:WBPaper00031293, WB:WBPerson712] is_a: WBPhenotype:0000024 ! serotonin_resistant is_a: WBPhenotype:0001629 ! egg_laying_serotonin_variant [Term] id: WBPhenotype:0001069 name: increased_egg_laying_events_during_active def: "More eggs are laid during the active phase compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] is_a: WBPhenotype:0001067 ! active_phase_variant [Term] id: WBPhenotype:0001070 name: inactive_phase_short def: "The period during which a worm usually does not lay eggs is short compared with control animals, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:9697864, WB:cab] is_a: WBPhenotype:0001066 ! inactive_phase_variant [Term] id: WBPhenotype:0001071 name: active_phase_switch_defective def: "Activation of the active phase of egg laying is defective, leading to an abnormally long inactive phase, based on the analysis of the distribution of the log intervals of egg-laying events." [pmid:10757762, pmid:9697864, WB:cab] is_a: WBPhenotype:0001064 ! inactive_phase_long [Term] id: WBPhenotype:0001072 name: response_to_food_variant def: "Any variation in the state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to a food stimulus, compared to control." [GO:0032094, WB:WBPerson2021] synonym: "response_to_food_abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0001073 name: egg_laying_response_to_food_variant def: "Animals exhibit variations in egg-laying behavior in response to food compared to control. In C. elegans, well-fed animals lay more eggs compared with starved animals." [pmid:10757762, WB:cab] synonym: "egg_laying_response_to_food_abnormal" NARROW [] is_a: WBPhenotype:0000640 ! egg_laying_variant is_a: WBPhenotype:0001072 ! response_to_food_variant [Term] id: WBPhenotype:0001074 name: vulval_muscle_unresponsive_to_serotonin def: "The vulval muscle does not respond to serotonin in the same manner as control animals. This phenotype is often assayed by imaging of calcium transients in response to serotonin." [pmid:14588249, WB:cab] is_a: WBPhenotype:0001068 ! egg_laying_serotonin_resistant is_a: WBPhenotype:0001076 ! vulval_muscle_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001075 name: vulval_muscle_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the vulva muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "vulval_muscle_physiology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000613 ! reproductive_system_physiology_variant [Term] id: WBPhenotype:0001076 name: vulval_muscle_homeostasis_metabolism_variant def: "Variations in the chemical reactions and pathways involved in the maintenance of an internal equilibrium within the vulval muscles compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "vulval_muscle_homeostasis_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0001075 ! vulval_muscle_physiology_variant [Term] id: WBPhenotype:0001077 name: chromosome_segregation_variant_karyomeres_early_emb def: "Karyomeres in AB or P1 often accompanied by weak/thin wobbly spindle." [WB:cab, WB:cgc7141] synonym: "chromosome_segregation_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000773 ! chromosome_segregation_variant is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001078 name: cytokinesis_defective_early_emb def: "Cytokinesis is abnormal in the first or second stages of cell division." [WB:cab, WB:cgc7141] synonym: "Cyk" BROAD three_letter_name [] synonym: "cytokinesis_abnormal" NARROW [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001018 ! cytokinesis_variant_emb is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001079 name: cytoplasmic_dynamics_defective_early_emb def: "Cytoplasmic movements are atypical." [WB:cab, WB:WBPerson1815] synonym: "cytoplasmic_dynamics_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000769 ! cytoplasmic_appearance_defective_early_emb [Term] id: WBPhenotype:0001080 name: excessive_blebbing_early_emb def: "Excessive shaking and movements are seen in the cell membrane or cytoplasm of one-cell or two-cell embryos." [cgc:5599, WB:cab] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001079 ! cytoplasmic_dynamics_defective_early_emb [Term] id: WBPhenotype:0001081 name: cytoplasmic_morphology_defective_early_emb def: "Morphology of the cytoplasm differs from control animals." [WB:cab, WB:WBPerson1815] synonym: "cytoplasmic_morphology_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000769 ! cytoplasmic_appearance_defective_early_emb [Term] id: WBPhenotype:0001082 name: large_cytoplasmic_granules_early_emb def: "Abnormally large granules are observed in the cytoplasm of P0." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001081 ! cytoplasmic_morphology_defective_early_emb [Term] id: WBPhenotype:0001083 name: multiple_cytoplasmic_cavities_early_emb def: "Multiple vesicles, vacuoles, or cavities are seen during early embryogenesis." [cgc:5599, WB:cab] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001081 ! cytoplasmic_morphology_defective_early_emb [Term] id: WBPhenotype:0001084 name: sodium_chloride_chemotaxis_defective alt_id: WBPhenotype:0000995 def: "Failure to execute characteristic response to sodium chloride compared to control. In C. elegans, animals move towards attractive concentrations of sodium chloride." [WB:WBPaper00000119] synonym: "NaCl_chemotaxis_defective" EXACT [] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001462 ! sodium_chloride_chemotaxis_variant [Term] id: WBPhenotype:0001085 name: butanone_chemotaxis_defective def: "Failure to execute characteristic response to butanone compared to control. In C. elegans, animals move towards typically attractive concentrations of butanone." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001469 ! butanone_chemotaxis_variant [Term] id: WBPhenotype:0001086 name: trimethylthiazole_chemotaxis_defective def: "Failure to execute characteristic response to trimethylthiazole compared to control. In C. elegans, animals move towards typically attractive concentrations of trimethylthiazole." [WB:WBPaper00001786] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001475 ! trimethylthiazole_chemotaxis_variant [Term] id: WBPhenotype:0001087 name: acetone_chemotaxis_defective def: "Failure to execute characteristic response to acetone compared to control. In C. elegans, animals move towards typically attractive concentrations of acetone." [WB:WBPaper00024240] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001465 ! acetone_chemotaxis_variant [Term] id: WBPhenotype:0001088 name: pentanol_chemotaxis_defective def: "Failure to execute characteristic response to pentanol compared to control. In C. elegans, animals move towards typically attractive concentrations of pentanol." [WB:WBPerson2021] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001473 ! pentanol_chemotaxis_variant [Term] id: WBPhenotype:0001089 name: hexanol_chemotaxis_defective def: "Failure to execute characteristic response to hexanol compared to control. In C. elegans, animals move towards typically attractive concentrations of hexanol." [WB:WBPerson2021] is_a: WBPhenotype:0001438 ! odorant_positive_chemotaxis_defective is_a: WBPhenotype:0001471 ! hexanol_chemotaxis_variant [Term] id: WBPhenotype:0001090 name: thermotolerance_reduced def: "Animals are not able to survive at temperatures above standard cultivation temperatures to the same extent as control animals." [WB:WBPerson712] is_a: WBPhenotype:0000146 ! organism_temperature_response_variant [Term] id: WBPhenotype:0001091 name: larval_defecation_variant def: "Animals exhibit variations in the elimination of fecal matter during the larval stage compared to control animals." [WB:WBPerson2021] synonym: "larval_defecation_abnormal" NARROW [] is_a: WBPhenotype:0000650 ! defecation_variant [Term] id: WBPhenotype:0001092 name: larval_defecation_defect def: "Animals fail to expel fecal matter during the larval stage." [WB:WBPerson2021] is_a: WBPhenotype:0001091 ! larval_defecation_variant [Term] id: WBPhenotype:0001093 name: intestinal_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the intestine to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "intestinal_physiology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000606 ! alimentary_system_physiology_variant [Term] id: WBPhenotype:0001094 name: NaCl_response_variant def: "Organismal response to NaCl differs from control animals." [WB:cab] synonym: "NaCl_response_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0001095 name: organism_high_sodium_chloride_hypersensitive def: "Animals respond to sodium chloride at a lower concentration or a shorter exposure compared to control animals. In C. elegans, this is often assayed through generation time and progeny number." [pmid:16027367, WB:cab] is_a: WBPhenotype:0000876 ! organism_osmotic_stress_response_variant [Term] id: WBPhenotype:0001096 name: protrusion_at_vulval_region def: "Large protrusion at the normal position of the vulva, as seen in C. elegans lin-12 null animals." [cgc:646, WB:cab] synonym: "ventral_protrusion" NARROW [] is_a: WBPhenotype:0000695 ! vulva_morphology_variant [Term] id: WBPhenotype:0001097 name: premature_spermatocyte_germ_cell_differentiation def: "Unspecialized male germ cells (spermatocytes) prematurely acquire the specialized properties of functional sperm." [cgc:4207, WB:cab, WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis_variant [Term] id: WBPhenotype:0001098 name: no_rectum def: "Animals lack the passage connecting the posterior intestine to the rectal valve." [WB:WBPaper00001423, WB:WBPerson2021] comment: WBbt:0005773 is_a: WBPhenotype:0000910 ! rectal_morphology_variant [Term] id: WBPhenotype:0001099 name: nose_twisted def: "The extreme anterior part of the body appears distorted, usually due to uncharacteristic winding." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000321 ! nose_morphology_variant [Term] id: WBPhenotype:0001100 name: early_embryonic_lethal def: "Animal dies prior to the gastrulation stage of embryogenesis." [WB:WBPerson2021] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0001101 name: egg_laying_response_to_drug_variant def: "Characteristic response to drugs with respect to egg-laying behavior varies compared to control." [WB:cab] synonym: "egg_laying_response_to_drug_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant is_a: WBPhenotype:0000640 ! egg_laying_variant [Term] id: WBPhenotype:0001102 name: mitotic_spindle_defective_early_emb def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a mitotic cell cycle." [GO:0007052, WB:WBPerson2021] comment: possible XP synonym: "Emb" BROAD three_letter_name [] synonym: "mitotic_spindle_abnormal" NARROW [] is_a: WBPhenotype:0000759 ! spindle_defective_early_emb [Term] id: WBPhenotype:0001103 name: spindle_absent_early_emb def: "Early embryos lack the array of microtubules and associated molecules that form between opposite poles of a eukaryotic cell during mitosis or meiosis." [GO:0005819, WB:WBPerson2021] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001102 ! mitotic_spindle_defective_early_emb [Term] id: WBPhenotype:0001104 name: P0_spindle_absent_early_emb def: "No mitotic spindle is seen in P0." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001103 ! spindle_absent_early_emb [Term] id: WBPhenotype:0001105 name: P0_spindle_position_defective_early_emb def: "Altered P0 spindle placement causes either a symmetric first division, a division in which P1 is larger than AB, or a division in which the asymmetry is exaggerated such that AB is much larger than normal." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] synonym: "P0_spindle_position_abnormal" NARROW [] is_a: WBPhenotype:0000762 ! spindle_position_defective_early_emb [Term] id: WBPhenotype:0001106 name: spindle_orientation_variant_AB_or_P1_early_emb def: "The orientation of the spindle is aberrant in either the AB or the P1 cell." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] synonym: "spindle_orientation_abnormal" NARROW [] is_a: WBPhenotype:0000760 ! spindle_orientation_defective_early_emb [Term] id: WBPhenotype:0001107 name: spindle_rotation_defective_early_emb def: "Rotation of the embryonic spindle is aberrant." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "spindle_rotation_abnormal" NARROW [] is_a: WBPhenotype:0001102 ! mitotic_spindle_defective_early_emb [Term] id: WBPhenotype:0001108 name: P0_spindle_rotation_failure_early_emb def: "P0 spindle fails to rotate and extends perpendicular to the long axis of the embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001107 ! spindle_rotation_defective_early_emb [Term] id: WBPhenotype:0001109 name: P0_spindle_rotation_delayed_early_emb def: "P0 spindle rotates late in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001107 ! spindle_rotation_defective_early_emb [Term] id: WBPhenotype:0001110 name: aster_defective_early_emb def: "Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores." [GO:0005818, WB:WBPerson2021, WB:WBPerson557] synonym: "aster_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001111 name: aster_AB_defective_early_emb def: "Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the AB cell." [WB:WBPerson2021, WB:WBPerson557] synonym: "aster_AB_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001110 ! aster_defective_early_emb [Term] id: WBPhenotype:0001112 name: aster_AB_resembles_P1_aster_early_emb def: "The morphology of the AB aster resembles that of the P1 aster in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001111 ! aster_AB_defective_early_emb [Term] id: WBPhenotype:0001113 name: P1_aster_defective_early_emb def: "Early embryos exhibit defects in the array of microtubules emanating from a spindle pole that do not connect to kinetochores in the P1 cell." [WB:cab, WB:cgc5599, WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD three_letter_name [] synonym: "P1_aster_abnormal" NARROW [] is_a: WBPhenotype:0001110 ! aster_defective_early_emb [Term] id: WBPhenotype:0001114 name: cell_cycle_defective_early_emb def: "The progression of biochemical and morphological processes that occur during successive replication or nuclear replication events is disrupted during the early embryonic stage." [WB:WBPerson2021, WB:WBPerson557] synonym: "cell_cycle_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000740 ! cell_cycle_variant is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001115 name: cell_cycle_timing_defective_early_emb def: "Cell cycle timing is abnormal during the first four cell divisions." [WB:cab, WB:WBPerson1815] synonym: "cell_cycle_timing_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001114 ! cell_cycle_defective_early_emb [Term] id: WBPhenotype:0001116 name: absolute_cell_cycle_timing_defective_early_emb def: "Absolute cell cycle timing during the first four cell divisions is aberrant." [WB:WBPerson557] synonym: "absolute_cell_cycle_timing_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001115 ! cell_cycle_timing_defective_early_emb [Term] id: WBPhenotype:0001117 name: cell_cell_contacts_defective_early_emb def: "Cell-cell contacts are abnormal in the early embryo." [WB:cab, WB:WBPerson1815] synonym: "cell_cell_contacts_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001118 name: cell_position_defective_early_emb def: "Cell position is abnormal in the early embryo." [WB:cab, WB:WBPerson1815] synonym: "cell_position_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001119 name: cell_cycle_slow_early_emb def: "Embryos take longer to divide during the first and second cell divisions." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001116 ! absolute_cell_cycle_timing_defective_early_emb [Term] id: WBPhenotype:0001120 name: relative_cell_cycle_timing_defective_early_emb def: "Relative cell cycle timing during the first four cell divisions is aberrant." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "relative_cell_cycle_timing_abnormal" NARROW [] is_a: WBPhenotype:0001115 ! cell_cycle_timing_defective_early_emb [Term] id: WBPhenotype:0001121 name: exaggerated_asynchrony_early_emb def: "Asynchrony of the second division is exaggerated and P1 divides more slowly than normal." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_defective_early_emb [Term] id: WBPhenotype:0001122 name: reversed_asynchrony_early_emb def: "P1 divides before AB." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_defective_early_emb [Term] id: WBPhenotype:0001123 name: synchronous_second_division_early_emb def: "AB and P1 divide synchronously." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_defective_early_emb [Term] id: WBPhenotype:0001124 name: ABa_ABp_EMS_synchronous_division_early_emb def: "EMS divides at the same time that ABa and ABp divide." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_defective_early_emb [Term] id: WBPhenotype:0001125 name: P2_EMS_synchronous_division_early_emb def: "P2 and EMS divide synchronously." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_defective_early_emb [Term] id: WBPhenotype:0001126 name: cell_cell_contacts_variant_four_emb def: "Aba, ABp, EMS, or P1 contacts fewer of its sister cells than in control embryos." [WB:cab, WB:cgc5599] synonym: "cell_cell_contacts_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001117 ! cell_cell_contacts_defective_early_emb [Term] id: WBPhenotype:0001127 name: EMS_anterior_extension_fails_early_emb def: "EMS fails to extend anteriorly and \"hug\" ABa." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001118 ! cell_position_defective_early_emb [Term] id: WBPhenotype:0001128 name: EMS_anterior_extension_extreme_early_emb def: "EMS extends too far anteriorly at the four cell stage." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001118 ! cell_position_defective_early_emb [Term] id: WBPhenotype:0001129 name: cleavage_furrow_defective_early_emb def: "Embryos exhibit defects in the formation or maintenance of the shallow groove in the cell surface near the old metaphase plate at the onset of cytokinesis." [GO:0032154, WB:WBPerson2021, WB:WBPerson557] synonym: "cleavage_furrow_abnormal" RELATED [] synonym: "cleavage_furrow_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001130 name: cytokinesis_fails_early_emb def: "Cells of the embryo attempt to divide but fail to form two daughter cells." [WB:cab, WB:cgc5599] synonym: "Cyk" BROAD three_letter_name [] synonym: "Emb" BROAD [] is_a: WBPhenotype:0001078 ! cytokinesis_defective_early_emb [Term] id: WBPhenotype:0001131 name: loose_mitotic_furrow_early_emb def: "Once formed, the mitotic furrow can \"slide\"laterally." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001129 ! cleavage_furrow_defective_early_emb [Term] id: WBPhenotype:0001132 name: ectopic_cleavage_furrows_early_emb def: "Extra cleavage furrows are seen in one or all cells of a one-cell to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001129 ! cleavage_furrow_defective_early_emb [Term] id: WBPhenotype:0001133 name: division_axis_defective_early_emb def: "Division axis within the first four divisions is not normal." [WB:cab, WB:WBPerson1815] synonym: "division_axis_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001134 name: Aba_ABp_division_axis_defective_early_emb def: "ABa or ABp divide in the wrong orientation." [WB:cab, WB:cgc5599] synonym: "Aba_ABp_division_axis_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001133 ! division_axis_defective_early_emb [Term] id: WBPhenotype:0001135 name: embryonic_morphology_defective_early_emb def: "Animals exhibit defects in the form, structure or composition of any of its parts during the early embryonic stage. " [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD three_letter_name [] synonym: "embryonic_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal is_a: WBPhenotype:0001136 ! embryonic_morphology_variant [Term] id: WBPhenotype:0001136 name: embryonic_morphology_variant def: "Animals exhibit variations in the form, structure or composition of any of its parts during any developmental stage ranging from zygote formation to hatching compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "embryonic_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000037 ! egg_morphology_variant [Term] id: WBPhenotype:0001137 name: embryos_small_early_emb def: "Embryos are produced that are less than fifty percent of the size of control embryos." [WB:cab, WB:WBPaper00005599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001135 ! embryonic_morphology_defective_early_emb [Term] id: WBPhenotype:0001138 name: nucleus_defective_early_emb def: "Nucleus is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "nucleus_abnormal" NARROW [] is_a: WBPhenotype:0001034 ! pronuclear_nuclear_appearance_defective_early_emb [Term] id: WBPhenotype:0001139 name: nuclear_envelope_assembly_variant_early_emb def: "Nuclear envelope does not reassemble properly." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] synonym: "nuclear_reassembly_abnormal" NARROW [] synonym: "nuclear_reassembly_defective_early_emb" RELATED [] is_a: WBPhenotype:0001138 ! nucleus_defective_early_emb [Term] id: WBPhenotype:0001140 name: neuron_migration_variant def: "Any variation in the normal orderly movement of neurons from one site to another compared to control." [WB:WBPerson2021] synonym: "neuron_migration_abnormal" NARROW [] is_a: WBPhenotype:0000594 ! cell_migration_variant [Term] id: WBPhenotype:0001141 name: nucleus_reforms_cell_division_remnant_early_emb def: "After division of either one-cell or two-cell embryos, the nuclei reappear next to the cell division remnant." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001027 ! nuclear_position_defective_early_emb [Term] id: WBPhenotype:0001142 name: nuclear_number_defective_early_emb def: "Nuclear number is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "nuclear_number_abnormal" NARROW [] is_a: WBPhenotype:0001035 ! nuclear_appearance_number_defective_early_emb [Term] id: WBPhenotype:0001143 name: multiple_nuclei_early_emb def: "Embryos contain more than one nucleus per cell in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD [] synonym: "karyomeres" RELATED [] synonym: "Mul" BROAD three_letter_name [] synonym: "multiple_nuclei_in_early_embryo_emb" RELATED [] is_a: WBPhenotype:0000746 ! cell_division_variant is_a: WBPhenotype:0001142 ! nuclear_number_defective_early_emb [Term] id: WBPhenotype:0001144 name: polar_body_number_size_early_emb def: "Defects are either seen in the number or size of the polar bodies in the inviable one- to four-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001147 ! polar_body_defective_early_emb [Term] id: WBPhenotype:0001145 name: polar_body_number_defective_early_emb def: "Polar body number is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "polar_body_number_abnormal" NARROW [] is_a: WBPhenotype:0001144 ! polar_body_number_size_early_emb [Term] id: WBPhenotype:0001146 name: polar_body_size_defective_early_emb def: "Polar body size is abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "polar_body_size_abnormal" NARROW [] is_a: WBPhenotype:0001144 ! polar_body_number_size_early_emb [Term] id: WBPhenotype:0001147 name: polar_body_defective_early_emb def: "Polar bodies are abnormal in the inviable one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "polar_body_abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001148 name: polar_body_reabsorbed_early_emb def: "Polar body is reabsorbed in the one- to four-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0000777 ! polar_body_extrusion_defective_early_emb [Term] id: WBPhenotype:0001149 name: polar_body_reabsorbed_first_early_emb synonym: "Emb" BROAD three_letter_name [] is_obsolete: true [Term] id: WBPhenotype:0001150 name: polar_body_reabsorbed_one_two_early_emb def: "A polar body is reabsorbed in either the one cell- or the two-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001148 ! polar_body_reabsorbed_early_emb [Term] id: WBPhenotype:0001151 name: pronucleus_centrosomes_defective_early_emb def: "Pronucleus is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "pronucleus_centrosomes_abnormal" NARROW [] is_a: WBPhenotype:0001034 ! pronuclear_nuclear_appearance_defective_early_emb [Term] id: WBPhenotype:0001152 name: pronuclear_migration_defective_early_emb def: "Pronucleus migration is abnormal in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "pronuclear_migration_abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_defective_early_emb [Term] id: WBPhenotype:0001153 name: pronuclear_migration_failure_early_emb def: "Neither of the pronuclei migrate and they never meet." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001152 ! pronuclear_migration_defective_early_emb [Term] id: WBPhenotype:0001154 name: paternal_pronucleus_migrates_early_emb def: "Instead of the maternal pronucleus migrating to the posterior end of the one-cell embryo, the paternal pronucleus migrates to meet the maternal pronucleus in the anterior end." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001152 ! pronuclear_migration_defective_early_emb [Term] id: WBPhenotype:0001155 name: pronuclei_meet_centrally_early_emb def: "The maternal and paternal pronuclei meet more centrally instead of meeting in the posterior end of the embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001152 ! pronuclear_migration_defective_early_emb [Term] id: WBPhenotype:0001156 name: pronuclear_size_defective_early_emb def: "Maternal or paternal pronucleus is either too small or too large." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] synonym: "pronuclear_size_abnormal" NARROW [] is_a: WBPhenotype:0001159 ! pronuclear_morphology_defective_early_emb [Term] id: WBPhenotype:0001157 name: pronuclear_breakdown_defective_early_emb def: "Pronuclear breakdown is atypical in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "pronuclear_breakdown_abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_defective_early_emb [Term] id: WBPhenotype:0001158 name: pronuclear_breakdown_asynchronous_early_emb def: "Instead of breaking down synchronously, the two pronuclei break down asynchronously in the inviable one-cell embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001157 ! pronuclear_breakdown_defective_early_emb [Term] id: WBPhenotype:0001159 name: pronuclear_morphology_defective_early_emb def: "Pronucleus morphology is atypical in the inviable embryo." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] synonym: "pronuclear_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_defective_early_emb [Term] id: WBPhenotype:0001160 name: pronuclear_envelope_morphology_defective_early_emb def: "Morphology of the pronuclear envelope is atypical in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "pronuclear_envelope_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001159 ! pronuclear_morphology_defective_early_emb [Term] id: WBPhenotype:0001161 name: maternal_pronucleus_indistinct_early_emb def: "Maternal pronucleus has a blurry appearance. The nuclear envelope does not have a crisp circular shape." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001160 ! pronuclear_envelope_morphology_defective_early_emb [Term] id: WBPhenotype:0001162 name: pronuclear_number_defective_early_emb def: "There are more than two pronuclei in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "pronuclear_number_abnormal" NARROW [] is_a: WBPhenotype:0001151 ! pronucleus_centrosomes_defective_early_emb [Term] id: WBPhenotype:0001163 name: pronucleus_formation_failure_early_emb def: "Either the maternal or paternal pronucleus is absent." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001162 ! pronuclear_number_defective_early_emb [Term] id: WBPhenotype:0001164 name: excess_pronucleus_early_emb def: "There is either more than one maternal or paternal pronucleus in the inviable embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001162 ! pronuclear_number_defective_early_emb [Term] id: WBPhenotype:0001165 name: excess_maternal_pronucleus_early_emb def: "One-cell embryos have two or more maternal pronuclei." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001164 ! excess_pronucleus_early_emb [Term] id: WBPhenotype:0001166 name: excess_paternal_pronucleus_variant_centrosome_early_emb def: "More than one paternal pronucleus is present in the inviable one-cell embryo or there is a defect in centrosome structure." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] synonym: "excess_paternal_pronucleus_abnormal" NARROW [] is_a: WBPhenotype:0001164 ! excess_pronucleus_early_emb [Term] id: WBPhenotype:0001167 name: pseudocleavage_defective_early_emb def: "Pseudocleavage is atypical in the inviable one-cell embryo." [WB:cab, WB:WBPerson1815] synonym: "Emb" BROAD three_letter_name [] synonym: "pseudocleavage_abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001168 name: pseudocleavage_absent_early_emb def: "No pseudocleavage is observed before or during pronuclear migration." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] synonym: "no_pseudocleavage" RELATED [] is_a: WBPhenotype:0001167 ! pseudocleavage_defective_early_emb [Term] id: WBPhenotype:0001169 name: pseudocleavage_exaggerated_early_emb def: "Embryos have more pronounced pseudocleavage than normal." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001167 ! pseudocleavage_defective_early_emb [Term] id: WBPhenotype:0001170 name: sterile_F0_48_hours_post_injection def: "Injected worm stops producing embryos 48 hours after RNAi injection and contains no live/developing embryos at this time." [WB:cab, WB:cgc5599] synonym: "P0_sterile" NARROW [] synonym: "Ste" BROAD [] is_a: WBPhenotype:0000689 ! maternal_sterile [Term] id: WBPhenotype:0001171 name: shortened_life_span def: "The duration of viability in the adult phase of the life-cycle is less than that of control animals." [GO:0008340, WB:WBPerson712] synonym: "Age" BROAD three_letter_name [] synonym: "longevity_decreased" RELATED [] is_a: WBPhenotype:0000039 ! life_span_variant [Term] id: WBPhenotype:0001172 name: programmed_cell_death_variant def: "Developmentally regulated termination of a cell or cell group does not occur as in control animals." [WB:WBPerson712] synonym: "programmed_cell_death_abnormal" NARROW [] is_a: WBPhenotype:0000729 ! cell_death_variant [Term] id: WBPhenotype:0001173 name: non_apoptotic_cell_death_variant def: "Animals exhibit variations in the specific activation or halting of processes within a cell that occur through necrosis or programmed cell death pathways different from apoptosis, so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death, compared to control." [GO:0008219, WB:WBPerson712] synonym: "non_apoptotic_cell_death_abnormal" NARROW [] is_a: WBPhenotype:0001172 ! programmed_cell_death_variant [Term] id: WBPhenotype:0001174 name: chromosome_disjunction_defective def: "Chromosomes fail to segregate away from their homolog, resulting in gametes with no or extra copies of the chromosome." [WB:WBPerson712] synonym: "chromosome_disjunction_abnormal" NARROW [] is_a: WBPhenotype:0000775 ! meiosis_variant is_a: WBPhenotype:0001499 ! meiotic_chromosome_segregation_variant [Term] id: WBPhenotype:0001175 name: high_incidence_male_progeny def: "Higher numbers of male progeny occur in the population as a result of an increase in X chromosome nondisjunction compared to control" [WB:cab, WB:WBPaper00004402, WB:WBPaper00005654, WB:WBPerson712] synonym: "high_frequency_X_chromosome_nondisjunction" RELATED [] synonym: "Him" BROAD three_letter_name [] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001176 name: one_cell_shape_defective_early_emb def: "One-cell embryos have an altered shape." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] synonym: "one_cell_shape_abnormal" NARROW [] is_a: WBPhenotype:0001135 ! embryonic_morphology_defective_early_emb [Term] id: WBPhenotype:0001177 name: embryo_osmotic_pressure_sensitive_early_emb def: "Embryos rupture when placed on a 2% agar pad and covered with a coverslip." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001178 ! egg_integrity_defective_early_emb [Term] id: WBPhenotype:0001178 name: egg_integrity_defective_early_emb def: "The structure of the egg is impaired, flawed or no longer intact." [WB:WBPerson2021, WB:WBPerson557] synonym: "egg_integrity_abnormal" NARROW [] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001179 name: No_variantity_scored def: "Phenotypic examination of worms did not reveal an obvious abnormality compared with control animals." [WB:cab] comment: The phenotype ontology was restructured such that "Abnormal" is now the root term. The term "Abnormal" with a "Not" qualifier is a suggested replacement for this term. synonym: "No_abnormal" NARROW [] synonym: "WT" RELATED [] is_obsolete: true [Term] id: WBPhenotype:0001180 name: accumulated_germline_cell_corpses def: "Animals exhibit an increase in the quantity of germ line cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712] is_a: WBPhenotype:0000241 ! accumulated_cell_corpses [Term] id: WBPhenotype:0001181 name: accumulated_somatic_cell_corpses def: "Animals exhibit an increase in the quantity of non-germ line cells that have undergone programmed cell death but have not been engulfed." [WB:WBPerson712] is_a: WBPhenotype:0000241 ! accumulated_cell_corpses [Term] id: WBPhenotype:0001182 name: fat_content_variant def: "Animals exhibit variations in the amount of fat or lipids present in the organism compared to control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712] synonym: "fat_content_abnormal" NARROW [] is_a: WBPhenotype:0000725 ! lipid_metabolism_variant [Term] id: WBPhenotype:0001183 name: fat_content_reduced def: "Animals exhibit less fat or lipid than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712] is_a: WBPhenotype:0001182 ! fat_content_variant [Term] id: WBPhenotype:0001184 name: fat_content_increased def: "Animals exhibit a greater amount of fat or lipids than observed in control animals." [GO:0019915, WB:WBPaper00032082, WB:WBPerson712] is_a: WBPhenotype:0001182 ! fat_content_variant [Term] id: WBPhenotype:0001185 name: embryonic_developmental_delay_early_emb def: "The developmental progression of an early embryo over time, from its formation to its mature structure is delayed compared to control. " [WB:WBPerson2021, WB:WBPerson557] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001186 name: embryo_delayed_at_pronuclear_contact_early_emb def: "Embryos are either delayed or arrested at pronuclear contact." [WB:cab, WB:cgc5599] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001185 ! embryonic_developmental_delay_early_emb [Term] id: WBPhenotype:0001187 name: division_EMS_before_P2_early_emb def: "EMS divides before P2." [WB:WBPerson557] synonym: "Emb" BROAD three_letter_name [] is_a: WBPhenotype:0001120 ! relative_cell_cycle_timing_defective_early_emb [Term] id: WBPhenotype:0001188 name: radial_filament_structure_variant_pharynx def: "Animals exhibit variations in the form, structure or composition of radial arrangement of actin within the pharyngeal muscle compared to control animals." [WB:WBPaper00026850, WB:WBPerson2021, WB:WBPerson557] synonym: "radial_filament_structure_abnormal" NARROW [] relationship: part_of WBPhenotype:0001046 ! pharyngeal_muscle_morphology_variant [Term] id: WBPhenotype:0001189 name: adherens_junctions_variant_pharyngeal_muscle def: "Any variation in the cell junctions of the pharyngeal_muscle at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control." [WB:WBPaper00026850, WB:WBPerson2021, WB:WBPerson557] synonym: "adherens_junctions_abnormal" NARROW [] relationship: part_of WBPhenotype:0001046 ! pharyngeal_muscle_morphology_variant relationship: part_of WBPhenotype:0001745 ! adherens_junction_variant [Term] id: WBPhenotype:0001190 name: pharyngeal_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the pharynx to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "pharyngeal_physiology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000606 ! alimentary_system_physiology_variant [Term] id: WBPhenotype:0001191 name: pharyngeal_muscle_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for muscles in the pharynx to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "pharyngeal_muscle_physiology_abnormal" NARROW [] is_a: WBPhenotype:0001190 ! pharyngeal_physiology_variant [Term] id: WBPhenotype:0001192 name: calcium_signaling_pharynx_variant def: "Any variation in the series of molecular signals in which a pharyngeal cell uses calcium ions to convert an extracellular signal into a response, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "calcium_signaling_pharynx_abnormal" NARROW [] is_a: WBPhenotype:0001191 ! pharyngeal_muscle_physiology_variant [Term] id: WBPhenotype:0001193 name: disorganized_pharyngeal_EPG def: "Electropharyngeograms do not show a similar pattern as control animals. C. elegans animals show a repeating regular pattern in which each pump is associated with an excitatory depolarizing wave, often punctuated by brief negative spikes, followed by a plateau phase, and ending with an inhibitory hyperpolarizing wave." [WB:cab, WB:cgc7545] is_a: WBPhenotype:0000980 ! pharyngeal_contraction_variant [Term] id: WBPhenotype:0001194 name: ectopic_neuron def: "Animals have extra neurons, which are present in places they are normally not found, when compared to the number or location of these neurons in control animals." [WB:WBPaper00027335, WB:WBPerson712] is_a: WBPhenotype:0001303 ! ectopic_cell [Term] id: WBPhenotype:0001195 name: generation_calcium_signal_defective_pharynx def: "Rhythmic calcium increases in the pharynx are observed less often than in control animals. In C. elegans, rhythmic increases in intracellular calcium are often observed using a transgenically expressed cameleon, a ratiometric calcium indicator." [WB:cab, WB:cgc4194, WB:cgc7545] is_a: WBPhenotype:0001192 ! calcium_signaling_pharynx_variant [Term] id: WBPhenotype:0001196 name: synchronization_calcium_signal_defective_pharynx def: "Calcium spikes lack synchrony in the musculature of the corpus and the terminal bulb as seen in control." [WB:cab, WB:cgc7545] is_a: WBPhenotype:0001192 ! calcium_signaling_pharynx_variant [Term] id: WBPhenotype:0001197 name: somatic_gonad_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic gonad to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "somatic_gonad_physiology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000613 ! reproductive_system_physiology_variant [Term] id: WBPhenotype:0001198 name: somatic_sheath_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the somatic sheath system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "somatic_sheath_physiology_abnormal" NARROW [] is_a: WBPhenotype:0001197 ! somatic_gonad_physiology_variant [Term] id: WBPhenotype:0001199 name: gonad_sheath_contractions_variant def: "Animals exhibit variations in any physical or chemical process required for the contraction of a thin continuous tube surrounding the proximal portions of the ovary and covering the maturing oocytes to the near portion of the distal gonad arm, compared to control (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "gonad_sheath_contractions_abnormal" NARROW [] is_a: WBPhenotype:0001198 ! somatic_sheath_physiology_variant [Term] id: WBPhenotype:0001200 name: gonad_sheath_contraction_rate_reduced def: "Basal contraction rate and or peak contraction rate of the gonadal sheath is reduced relative to control animals." [WB:cab, WB:cgc7545] is_a: WBPhenotype:0001199 ! gonad_sheath_contractions_variant [Term] id: WBPhenotype:0001201 name: no_expulsion_defecation def: "Animals lack the stereotyped muscle contractions that result in the opening of anus." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000391 ! defecation_missing_motor_steps [Term] id: WBPhenotype:0001202 name: nicotine_hypersensitive def: "Animals respond to nicotine at lower concentrations or shorter exposure compared to control. Nicotine is a cholinergic agonist." [WB:cab, WB:cgc7388, WB:WBPerson557] is_a: WBPhenotype:0001573 ! nicotine_response_variant is_a: WBPhenotype:0001579 ! cholinergic_agonist_hypersensitive [Term] id: WBPhenotype:0001203 name: nicotine_resistant def: "Animals fail to respond to the concentration of nicotine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:cab, WB:cgc7388, WB:WBPerson557] is_a: WBPhenotype:0001573 ! nicotine_response_variant is_a: WBPhenotype:0001578 ! cholinergic_agonist_resistant [Term] id: WBPhenotype:0001204 name: muscimol_resistant def: "Animals fail to respond to the concentration of muscimol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001205 name: muscimol_hypersensitive def: "Animals respond to muscimol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0001206 name: movement_variant def: "Variations in the process by which an organism travels from one location to another compared to control." [WB:WBPerson2021, WB:WBPerson557] subset: phenotype_slim_wb synonym: "movement_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0001207 name: protein_signaling_variant def: "Any variation in a series of protein mediated signals that help relay information within the cell, and thereby affecting changes in the functioning of the cell, compared to control. " [WB:WBPerson2021, WB:WBPerson557] synonym: "protein_signaling_abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001208 name: RNAi_resistant def: "Animals show reduced susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000743 ! RNAi_response_variant [Term] id: WBPhenotype:0001209 name: skiddy def: "Apparently normal sinusoidal movement, but appear to have poor traction on the agar surface of a culture plate." [WB:cab, WB:WBPaper00026735] synonym: "Skd" BROAD three_letter_name [] is_a: WBPhenotype:0001701 ! spastic_locomotion [Term] id: WBPhenotype:0001210 name: pericellular_component_physiology_variant def: "Animals exhibit variations in any physical or chemical process taking place in extracellular spaces within or associated with the organism, from that observed for control animals." [WB:WBPerson712] subset: phenotype_slim_wb synonym: "pericellular_component_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000519 ! physiology_variant [Term] id: WBPhenotype:0001211 name: cuticle_integrity_variant def: "The physical strength or function of the cuticle is varies from that observed for control animals." [WB:WBPerson712] synonym: "cuticle_integrity_abnormal" NARROW [] is_a: WBPhenotype:0001678 ! cuticle_physiology_variant [Term] id: WBPhenotype:0001212 name: cuticle_fragile def: "The strength of the cuticle is less robust than that observed for control animals. In C. elegans the strength of the cuticle is often assayed by it's ability to protect the animal from exposure to bleach or other compounds." [WB:WBPerson712] is_a: WBPhenotype:0001211 ! cuticle_integrity_variant [Term] id: WBPhenotype:0001213 name: locomotion_reduced alt_id: WBPhenotype:0001288 def: "Animals exhibit a decrease in any parameter used to measure locomotion compared to control animals." [WB:cab] synonym: "movement_reduced" EXACT [] is_a: WBPhenotype:0000641 ! activity_level_variant [Term] id: WBPhenotype:0001214 name: metaphase_to_anaphase_transition_fails is_obsolete: true [Term] id: WBPhenotype:0001215 name: germ_cell_mitosis_variant def: "Variations in the mitotic expansion of germ cell populations or in the appearance of nuclei during development in the premeiotic region of the germline compared to control." [WB:WBPaper00001007, WB:WBPaper00005486, WB:WBPerson2021] synonym: "germ_cell_mitosis_abnormal" NARROW [] is_a: WBPhenotype:0000823 ! germline_proliferation_variant [Term] id: WBPhenotype:0001216 name: meiosis_metaphase_to_anaphase_transition_block def: "Oocyte chromosomes arrest in metaphase of meiosis I without transitioning to anaphase or producing polar bodies." [pmid:11134076, WB:cab] synonym: "Mat" BROAD three_letter_name [] is_a: WBPhenotype:0000776 ! passage_through_meiosis_defective_early_emb is_a: WBPhenotype:0001496 ! metaphase_to_anaphase_transition_defect [Term] id: WBPhenotype:0001217 name: germ_cell_mitosis_metaphase_to_anaphase_transition_block def: "Germ line cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0001215 ! germ_cell_mitosis_variant is_a: WBPhenotype:0001497 ! mitotic_metaphase_to_anaphase_transition_defect [Term] id: WBPhenotype:0001218 name: cell_death_sexually_dimorphic_variant def: "Animals exhibit variations in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations." [WB:WBPerson712] synonym: "cell_death_sexually_dimorphic_abnormal" NARROW [] is_a: WBPhenotype:0000730 ! apoptosis_variant [Term] id: WBPhenotype:0001219 name: cell_survival_sexually_dimorphic_increased def: "Animals exhibit a decrease in the rate or extent of programmed cell death and thus an increase in cell survival, as it pertains to a sex-specific feature, compared to control populations." [WB:WBPerson712] is_a: WBPhenotype:0001218 ! cell_death_sexually_dimorphic_variant [Term] id: WBPhenotype:0001220 name: cell_death_sexually_dimorphic_increased def: "Animals exhibit in increase in the rate or extent of programmed cell death as it pertains to a sex-specific feature, compared to control populations." [WB:WBPerson712] is_a: WBPhenotype:0001218 ! cell_death_sexually_dimorphic_variant [Term] id: WBPhenotype:0001221 name: nose_touch_defective def: "Animal fails to exhibit characteristic response after a nose-on collision with an object compared to control. In C. elegans, this is usually assayed with a hair or similar fiber. The nose is the anterior most tip of the animal." [WB:WBPaper00001705, WB:WBPerson557] is_a: WBPhenotype:0000456 ! touch_resistant is_a: WBPhenotype:0004026 ! nose_touch_variant [Term] id: WBPhenotype:0001222 name: transposon_mutator def: "Animals exhibit an increase in frequency of transposition events (DNA movement to different positions within the genome of a single cell) causing an accumulation of lesions within the genome, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "Mut" RELATED [] synonym: "mutator" RELATED [] is_a: WBPhenotype:0000228 ! spontaneous_mutation_rate_increased [Term] id: WBPhenotype:0001223 name: germline_RNAi_resistant def: "Animals show reduced susceptibility to gene silencing in the germline triggered by double stranded RNA (RNAi), compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001208 ! RNAi_resistant [Term] id: WBPhenotype:0001224 name: axon_outgrowth_variant def: "Any variation in the processes that govern the extension of axons compared to control." [GO:0048675, WB:WBPerson2021] synonym: "axon_outgrowth_abnormal" NARROW [] is_a: WBPhenotype:0000572 ! neuronal_outgrowth_variant [Term] id: WBPhenotype:0001225 name: phasmid_socket_absent def: "Animals are missing the interfacial hypodermal cell (socket cell) of the phasmid sensillum pore." [WB:WBPaper00000938, WB:WBPaper00004350, WB:WBPaper00026656, WB:WBPerson712] synonym: "Psa" RELATED [] is_a: WBPhenotype:0000257 ! phasmid_morphology_variant [Term] id: WBPhenotype:0001226 name: commissure_variant def: "Animals display variations in the structure, organization or path of the part of the axon that forms a bridge between body regions, compared to that in control animals." [WB:WBPaper00000938, WB:WBPaper00001576, WB:WBPaper00029065, WB:WBPerson712] synonym: "commissure_abnormal" NARROW [] is_a: WBPhenotype:0000181 ! axon_trajectory_variant [Term] id: WBPhenotype:0001227 name: commissure_absent def: "Animals are missing any one of its commissures, an axon tract that connects one body part to another." [WB:WBPaper00027335, WB:WBPerson712] is_a: WBPhenotype:0001226 ! commissure_variant [Term] id: WBPhenotype:0001228 name: alae_absent def: "Animals lack the small linear ridges running along the lateral lines of the cuticle, lengthwise along the body (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000202 ! alae_variant [Term] id: WBPhenotype:0001229 name: anterior_neuron_migration_defective def: "The orderly movement of neurons along the anterior axis of the animal is abolished, misdirected or incomplete compared to control." [WB:WBPerson2021] synonym: "abnormal_anterior_neuron_migration" NARROW [] is_a: WBPhenotype:0001140 ! neuron_migration_variant [Term] id: WBPhenotype:0001230 name: anterior_cell_migration_defective def: "The orderly movement of cells along the anterior axis of the animal is abolished, misdirected or incomplete compared to control." [WB:WBPerson2021] synonym: "abnormal_anterior_cell_migration" NARROW [] is_a: WBPhenotype:0000594 ! cell_migration_variant [Term] id: WBPhenotype:0001231 name: intraflagellar_transport_accelerated def: "The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is increased compared to control." [WB:WBPerson2021] synonym: "ift_accelerated" RELATED [] is_a: WBPhenotype:0000853 ! intraflagellar_transport_variant [Term] id: WBPhenotype:0001232 name: serotonin_response_variant def: "Animals exhibit variations in the response to the addition of serotonin compared to that observed in control animals. Serotonin is a monoamine neurotransmitter." [WB:WBPerson557] synonym: "serotonin_response_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001233 name: DAPI_staining_variant def: "Animals exhibit variations in the pattern of a chemical nuclear stain which is commonly used in fixed specimens and produces a bright blue label, compared to control. DAPI (4'-6-Diamidino-2-phenylindole) forms fluorescent complexes with natural double-stranded DNA (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "DAPI_staining_abnormal" NARROW [] is_a: WBPhenotype:0010002 ! cell_organization_biogenesis_variant [Term] id: WBPhenotype:0001234 name: nonanone_chemotaxis_defective def: "Failure to execute the characteristic response to nonanone compared to control. In C. elegans, nonanone is a repellant" [WB:WBPaper00002917] is_a: WBPhenotype:0001448 ! odorant_negative_chemotaxis_defective is_a: WBPhenotype:0001456 ! nonanone_chemotaxis_variant [Term] id: WBPhenotype:0001235 name: cell_division_polarity_variant def: "Any variation in the orientation of the physical partitioning and separation of a cell into daughter cells compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "cell_division_polarity_abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0001236 name: transgene_expression_increased def: "Any increase in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] is_a: WBPhenotype:0000962 ! level_of_transgene_expression_variant [Term] id: WBPhenotype:0001237 name: ectopic_axon_outgrowth def: "Any perturbation that causes an increase in the frequency of axon outgrowth compared to control. As a result, an excess number of axonal projections are generated." [GO:0030517, WB:WBPerson2021] is_a: WBPhenotype:0000629 ! ectopic_neurite_outgrowth is_a: WBPhenotype:0001224 ! axon_outgrowth_variant [Term] id: WBPhenotype:0001238 name: male_mating_latency_variant def: "Any variation in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva." [pmid:16624900, WB:cab] synonym: "male_mating_latency_abnormal" NARROW [] is_a: WBPhenotype:0000648 ! male_mating_variant [Term] id: WBPhenotype:0001239 name: mating_latency_increased def: "Any increase in the length of time required for a male to find a mate and initiate the search for the vulva. In C. elegans, the latency period includes the time males spend to find a hermaphrodite and pause to press its ventral side against the surface of the hermaphrodite and initiate a backing up search for the vulva." [pmid:16624900] is_a: WBPhenotype:0001238 ! male_mating_latency_variant is_a: WBPhenotype:0001414 ! male_mating_defective [Term] id: WBPhenotype:0001240 name: male_tail_sensory_ray_differentiation_variant def: "Variations in the processes leading to the specialization of the finger-like sensory sensilla that project from the tail and embed in the male fan compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_tail_sensory_ray_differentiation_abnormal" NARROW [] is_a: WBPhenotype:0000199 ! male_tail_sensory_ray_development_variant [Term] id: WBPhenotype:0001242 name: intraflagellar_transport_slow def: "The rate, frequency or extent of bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is lower compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000854 ! intraflagellar_transport_defective [Term] id: WBPhenotype:0001243 name: intraflagellar_transport_distance_short def: "The bidirectional transport of molecules (cargo) along axonemal microtubules is reduced compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001247 ! anterograde_transport_defective [Term] id: WBPhenotype:0001244 name: intraflagellar_transport_absent def: "Bidirectional movement of large protein complexes (mediated by motor proteins) along microtubules within a cilium or flagellum is completely abolished." [WB:WBPerson2021] is_a: WBPhenotype:0000854 ! intraflagellar_transport_defective [Term] id: WBPhenotype:0001245 name: no_transport_middle_segment_cilia def: "The bidirectional transport of molecules along the middle segment of axonemal microtubules of the cilia is absent." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001243 ! intraflagellar_transport_distance_short [Term] id: WBPhenotype:0001246 name: no_transport_distal_segment_cilia def: "The bidirectional transport of molecules along the distal segment of axonemal microtubules of the cilia is absent." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001243 ! intraflagellar_transport_distance_short [Term] id: WBPhenotype:0001247 name: anterograde_transport_defective def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons is disrupted." [WB:WBPerson2021, WB:WBPerson557] comment: possible XP is_a: WBPhenotype:0001477 ! anterograde_transport_variant [Term] id: WBPhenotype:0001248 name: wing_cilia_morphology_variant def: "Animals exhibit variations in the structure or organization of the microtuble-based projections that in control animals invaginate individually into the sheath cell of the neuronal sensillum rather than projecting through the socket cell to the outside. In C. elegans, the cilia of each wing cell has its own unique shape and as they are not exposed to the outside, they do not typically take up dyes." [WB:WBPaper00000932, WB:WBPaper00029016, WB:WBPerson712] synonym: "AWC_cilia_morphology_abnormal" RELATED [] synonym: "wing_cilia_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000615 ! cilia_morphology_variant [Term] id: WBPhenotype:0001249 name: amphid_channel_cilia_morphology_variant def: "Animals exhibit variations in the structure or composition of the dendritic projections of the amphid sensory neurons that traverse the sensillum pore to connect with the outside of the animal, compared to that observed in control animals. In C. elegans, amphid channel cilia morphology is frequently assayed by dye-filling experiments using FITC, DiI or DiO." [WB:WBPaper00000932, WB:WBPerson712] synonym: "amphid_channel_cilia_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000615 ! cilia_morphology_variant [Term] id: WBPhenotype:0001250 name: amphid_channel_axoneme_morphology_variant def: "Animals exhibit variations in the structure or composition of the microtuble-based fibrillar core, axoneme, of the cilia of the neurons that project through the sensillum pore to the outside of the animal, compared to that observed in control animals." [WB:WBPaper00000932, WB:WBPerson712] synonym: "amphid_channel_axoneme_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000262 ! axoneme_morphology_variant is_a: WBPhenotype:0001249 ! amphid_channel_cilia_morphology_variant [Term] id: WBPhenotype:0001251 name: amphid_channel_axoneme_short def: "The microtuble-based fibrillar-bundles of the amphid sensory cilia are reduced in length compared to those in control animals." [WB:WBPaper00000932, WB:WBPaper00027116, WB:WBPerson712] is_a: WBPhenotype:0001250 ! amphid_channel_axoneme_morphology_variant [Term] id: WBPhenotype:0001252 name: wing_cilia_axoneme_morphology_variant def: "Animals exhibit variations in the structure or organization of the microtubule-based fibrillar section, axoneme, of the cilia of the flat sheet-like cells associated with sensory function, from that observed in control animals." [WB:WBPerson712] synonym: "wing_cilia_axoneme_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001248 ! wing_cilia_morphology_variant [Term] id: WBPhenotype:0001253 name: wing_cilia_axoneme_short def: "The microtuble-based fibrillar-bundle, axoneme, of the wing cell cilia are reduced in length and do not extend into the sheath cell as far as they do in control animals." [WB:WBPerson712] is_a: WBPhenotype:0001252 ! wing_cilia_axoneme_morphology_variant [Term] id: WBPhenotype:0001254 name: amphid_channel_cilia_bulbous def: "The dendritic processes that normally extend through the amphid sensillum pore to the outside are truncated and have swollen ends as opposed to the extended and finger-like tips of channel cilia in control animals." [WB:WBPaper00027116, WB:WBPerson712] is_a: WBPhenotype:0001249 ! amphid_channel_cilia_morphology_variant [Term] id: WBPhenotype:0001255 name: wing_cilia_bulbous def: "Animals exhibit wing cell sensory cilia that are truncated and swollen unlike that observed in control animals." [WB:WBPaper00027116, WB:WBPerson712] is_a: WBPhenotype:0001248 ! wing_cilia_morphology_variant [Term] id: WBPhenotype:0001256 name: DNA_damage_induced_focus_formation_variant def: "Variations in the aggregation of molecules at the site of DNA strand breakage or damage compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "DNA_damage_induced_focus_formation_abnormal" NARROW [] synonym: "DNA_repair_induced_focus_formation" RELATED [] is_a: WBPhenotype:0000739 ! DNA_damage_response_variant [Term] id: WBPhenotype:0001257 name: cross_link_induced_focus_formation_variant def: "Variations in the generation of foci that mark sites of aberrant bonding of molecules to the DNA strand, compared to control. " [WB:WBPerson2021, WB:WBPerson557] synonym: "cross_link_induced_focus_formation_abnormal" NARROW [] is_a: WBPhenotype:0001256 ! DNA_damage_induced_focus_formation_variant [Term] id: WBPhenotype:0001258 name: RNAi_enhanced def: "Animals show increased susceptibility to gene silencing triggered by double stranded RNA (RNAi), compared to control." [WB:WBPerson2021] is_a: WBPhenotype:0000743 ! RNAi_response_variant [Term] id: WBPhenotype:0001259 name: hermaphrodite_fertility_reduced def: "Hermaphrodites exhibit a reduction in the production of new individuals owing to defects in gamete competence and/or function compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000806 ! hermaphrodite_fertility_variant [Term] id: WBPhenotype:0001260 name: oocyte_morphology_variant def: "Haploid female germ cells (oocytes) exhibit variations in their overall structure, appearance or contents compared to control." [WB:WBPaper00001883, WB:WBPerson2021] synonym: "oocyte_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000900 ! germ_cell_morphology_variant [Term] id: WBPhenotype:0001261 name: pale def: "Animals show deficiencies in chroma resulting in increased translucency." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000527 ! organism_pigmentation_variant [Term] id: WBPhenotype:0001262 name: vulval_development_incomplete def: "The developmental progression of the egg-laying organ of female and hermaphrodite nematodes is halted prior to the formation of the mature structure." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000699 ! vulva_development_variant [Term] id: WBPhenotype:0001263 name: peroxisome_morphology_variant def: "The morphological appearance of peroxisomes is variant compared to control animals." [WB:cab] synonym: "peroxisome_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0001264 name: peroxisome_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the peroxisome to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "peroxisome_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0001265 name: head_movement_variant def: "The anterior portion of the animal exhibits variations in its movement compared to control" [WB:WBPaper00000214] synonym: "Erratic head vibration" NARROW [] synonym: "head_movement_abnormal" NARROW [] is_a: WBPhenotype:0001699 ! localized_movement_variant [Term] id: WBPhenotype:0001266 name: genetic_pathway_activation_variant def: "Any variation in triggering of the set of interactions occurring between a group of genes who depend on each other's individual functions in order to make the aggregate function of the network available to the cell, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "genetic_pathway_activation_abnormal" NARROW [] is_a: WBPhenotype:0000074 ! genetic_pathway_variant [Term] id: WBPhenotype:0001267 name: induced_contraction_rate_variant def: "Any variation in the frequency of gonad sheath contractions triggered by internal or external stimuli compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "induced_contraction_rate_abnormal" NARROW [] is_a: WBPhenotype:0001199 ! gonad_sheath_contractions_variant [Term] id: WBPhenotype:0001268 name: induced_cell_death_variant def: "Animals exhibit variations in the extent of activation of programmed cell death, compared to control." [WB:WBPerson712] synonym: "induced_cell_death_abnormal" NARROW [] is_a: WBPhenotype:0000729 ! cell_death_variant [Term] id: WBPhenotype:0001269 name: pathogen_induced_cell_death_variant def: "Animals exhibit variations in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control." [WB:WBPerson712] synonym: "pathogen_induced_cell_death_abnormal" NARROW [] is_a: WBPhenotype:0001268 ! induced_cell_death_variant [Term] id: WBPhenotype:0001270 name: pathogen_induced_cell_death_reduced def: "Animals exhibit a decrease in the extent of activation of programmed cell death by exposure to a pathogen or pathogenic cue, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0001269 ! pathogen_induced_cell_death_variant [Term] id: WBPhenotype:0001271 name: pathogen_induced_death_increased def: "Animals are more prone to lethality as a result of infection compared to control." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001013 ! pathogen_susceptibility_increased [Term] id: WBPhenotype:0001272 name: vulval_cell_induction_variant alt_id: WBPhenotype:0000198 def: "Vulval precursor cells inappropriately adopt fates that are normally restricted to other vulval precursor cells compared to control." [WB:WBPerson2021] synonym: "vulval_cell_induction_abnormal" NARROW [] synonym: "vulval_precursor_cell_induction_abnormal" EXACT [] is_a: WBPhenotype:0000220 ! vulva_cell_fate_specification_variant [Term] id: WBPhenotype:0001273 name: organism_heat_response_variant def: "Any variation in the state or activity of an organism (in terms of movement, gene expression, etc.) in response to heat (high temperatures above the optimal temperature for that organism), compared to control. " [GO:0009408, WB:WBPerson2021] synonym: "organism_heat_response_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0001274 name: organism_heat_hypersensitive def: "Animals respond to heat at a lower temperature or a shorter exposure time compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001273 ! organism_heat_response_variant [Term] id: WBPhenotype:0001275 name: increased_genetic_pathway_signal def: "Any variation that increases the magnitude of a signal generated by a set of gene interactions in a given pathway, compared to control.\n" [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000074 ! genetic_pathway_variant [Term] id: WBPhenotype:0001276 name: ectopic_expression_transgene def: "Any variation in the cellular expression of a gene product produced by exogenous DNA that has been introduced into the organism such that it now expresses in cells/tissues not seen when compared to the expression of that gene product in control animals." [WB:WBPerson557] is_a: WBPhenotype:0000961 ! pattern_of_transgene_expression_variant [Term] id: WBPhenotype:0001277 name: transformer def: "XX animals are transformed into males or pseudomales ." [WB:cab, WB:WBPerson712] synonym: "Tra" RELATED [] is_a: WBPhenotype:0001572 ! masculinized [Term] id: WBPhenotype:0001278 name: transgene_expression_reduced def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] is_a: WBPhenotype:0000962 ! level_of_transgene_expression_variant [Term] id: WBPhenotype:0001279 name: transgene_expression_reduced_male def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the male, that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] is_a: WBPhenotype:0001278 ! transgene_expression_reduced [Term] id: WBPhenotype:0001280 name: transgene_expression_reduced_hermaphrodite def: "Any decrease in the intensity of expression of a gene product produced by exogenous DNA, exclusively in the hermaphrodite, that has been introduced into the organism compared to its expression in control animals." [WB:WBPerson557] is_a: WBPhenotype:0001278 ! transgene_expression_reduced [Term] id: WBPhenotype:0001281 name: stuffed_pharynx def: "Pharynx becomes clogged with food. In C. elegans, this is often a result of pharyngeal pumping defects." [WB:cab] is_a: WBPhenotype:0000634 ! pharyngeal_pumping_variant is_a: WBPhenotype:0000778 ! feeding_inefficient [Term] id: WBPhenotype:0001282 name: mitochondrial_metabolism_variant def: "Variations in the chemical reactions and pathways of the mitochondria compared to control." [WB:WBPerson2021] synonym: "mitochondrial_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0001283 ! organelle_metabolism_variant [Term] id: WBPhenotype:0001283 name: organelle_metabolism_variant def: "Variations in the chemical reactions and pathways of an organelle compared to control." [WB:WBPerson2021] synonym: "organelle_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001284 name: coenzyme_Q_depleted def: "Animals contain a lower level of coenzyme Q, an oil-soluble vitamin-like substance present in most eukaryotic cells, primarily in the mitochondria, compared to control. It is a component of the electron transport chain and participates in aerobic cellular respiration." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000026 ! lipid_depleted is_a: WBPhenotype:0001282 ! mitochondrial_metabolism_variant [Term] id: WBPhenotype:0001285 name: induced_pharyngeal_pumping_variant def: "Pharyngeal pumping is not influenced by treatment with specific compounds (eg: serotonin) in the same manner as control animals." [WB:WBPerson2021] synonym: "induced_pharyngeal_pumping_abnormal" NARROW [] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_variant [Term] id: WBPhenotype:0001286 name: food_suppressed_pumping_variant def: "Exposure to food does not reduce pharyngeal pumping to the same extent as observed in control animals." [WB:WBPerson2021] synonym: "food_suppressed_pumping_abnormal" NARROW [] is_a: WBPhenotype:0001072 ! response_to_food_variant is_a: WBPhenotype:0001287 ! suppressed_pharyngeal_pumping_defective [Term] id: WBPhenotype:0001287 name: suppressed_pharyngeal_pumping_defective def: "Animals do not exhibit a decrease in pumping rate when treated with specific compounds (such as pheromones) as is observed for control animals." [WB:WBPaper00032082, WB:WBPerson712] synonym: "suppressed_pharyngeal_pumping_abnormal" NARROW [] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_variant [Term] id: WBPhenotype:0001289 name: acetylcholinesterase_inhibitor_resistant def: "Animals fail to respond to the concentration of acetylcholinesterase inhibitor that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0001290 ! acetylcholinesterase_inhibitor_response_variant [Term] id: WBPhenotype:0001290 name: acetylcholinesterase_inhibitor_response_variant def: "Animals exhibit variations in their response to a specific acetylcholinesterase inhibitor compared to that observed in control animals." [WB:WBPerson557] synonym: "acetylcholinesterase_inhibitor_response_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001291 name: social_behavior_variant def: "Animals exhibit variations in actions and responses that occurs predominantly, or only, in individuals that are part of a group, from that observed for animals in a control group." [GO:0035176, WB:WBPerson712] synonym: "social_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0001292 name: body_wall_muscle_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for cells as a collective unit of the body wall muscle system to carry out their normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "body_wall_muscle_physiology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000611 ! muscle_system_physiology_variant [Term] id: WBPhenotype:0001293 name: larval_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the larva to carry out its normal metabolic functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson712] synonym: "larval_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism_physiology_variant [Term] id: WBPhenotype:0001294 name: head_bent def: "The most anterior portion of the animal is not aligned with the axis of the body." [WB:WBPaper00000031] is_a: WBPhenotype:0000071 ! head_morphology_variant [Term] id: WBPhenotype:0001295 name: body_twisted def: "Any portion of the animal, between the head and the tail, appears distorted, usually due to uncharacteristic winding." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000072 ! body_morphology_variant [Term] id: WBPhenotype:0001296 name: lannate_resistant def: "Animals fail to respond to the concentration of lannate that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001289 ! acetylcholinesterase_inhibitor_resistant [Term] id: WBPhenotype:0001297 name: male_tail_development_variant def: "Any variation in the process whose specific outcome is the progression of the male tail over time, from its formation to the mature structure, compared to control." [WB:WBPerson2021] synonym: "male_tail_development_abnormal" NARROW [] is_a: WBPhenotype:0000805 ! tail_development_variant [Term] id: WBPhenotype:0001298 name: hindgut_morphology_variant def: "Animals exhibit variations in the form, structure or composition of the more posterior portion of the intestine, just anterior to the sphincter valve, which is subject to squeezing by the somatal-intestinal muscles compared to control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "hindgut_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000710 ! intestinal_morphology_variant [Term] id: WBPhenotype:0001299 name: cell_division_variant_male def: "Any variation that alters the physical partitioning and separation of a cell into daughter cells in male animals compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "cell_division_abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0001300 name: germ_cell_cytoplasmic_morphology_variant def: "Any variation in the composition or structure of the contents within a germ cell, excluding the plasma membrane and nucleus, compared to control. Germ cells include sperm, oocytes, and their precursors. " [GO:0005737, WB:WBPerson2021, WB:WBPerson557] synonym: "germ_cell_cytoplasmic_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000900 ! germ_cell_morphology_variant [Term] id: WBPhenotype:0001301 name: P_granule_defective def: "Localization or structural appearance of P-granules is altered compared to control. P-granules are cytoplasmic structures associated with germ nuclei in the C. elegans gonad, and are localized exclusively to germ cells, or germ cell precursors, throughout the life cycle." [pmid:11262230, WB:cab] synonym: "P_granule_abnormal" NARROW [] is_a: WBPhenotype:0001300 ! germ_cell_cytoplasmic_morphology_variant [Term] id: WBPhenotype:0001302 name: P_granule_localization_defective def: "The restricted localization of P granules to germ cells or germ cell precursors is altered compared to control." [WB:WBPaper00001477, WB:WBPerson2021] synonym: "P_granule_localization_abnormal" NARROW [] is_a: WBPhenotype:0001301 ! P_granule_defective [Term] id: WBPhenotype:0001303 name: ectopic_cell def: "Animals have extra cells, which are present in places they are normally not found, when compared to the number or location of these cells in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000529 ! cell_development_variant [Term] id: WBPhenotype:0001304 name: hindgut_damaged def: "The terminal portion of the intestine exhibits structural defects such as scarring or blockage." [WB:cab, WB:WBPaper00003719] synonym: "Scar" BROAD three_letter_name [] is_a: WBPhenotype:0001298 ! hindgut_morphology_variant [Term] id: WBPhenotype:0001305 name: hook_morphology_variant def: "Any variation in the form or composition of the structure that lies on the ventral surface just anterior and central to the base of the spicule openings (small lump on the gubernaculum of the male tail) and contains a sensory structure called the hook sensillum, compared to control. In C. elegans the hook is necessary for proper male mating." [WB:WBPerson2021, WB:WBPerson557] synonym: "hook_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000070 ! male_tail_morphology_variant [Term] id: WBPhenotype:0001306 name: male_reproductive_system_morphology_variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the male reproductive system compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_reproductive_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000605 ! reproductive_system_morphology_variant [Term] id: WBPhenotype:0001307 name: reduced_body_bend def: "The maximum ventral and dorsal flex of the animal is reduced compared to that observed for control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001703 ! body_bend_variant [Term] id: WBPhenotype:0001308 name: weak_pumping def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding is not as robust as compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000634 ! pharyngeal_pumping_variant [Term] id: WBPhenotype:0001309 name: flat_locomotion_path alt_id: WBPhenotype:0000003 def: "Animals show a decrease in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "flattened_locomotion_path" EXACT [] is_a: WBPhenotype:0004022 ! amplitude_of_movement_variant [Term] id: WBPhenotype:0001310 name: neuron_positioning_variant def: "The placement of neuronal cells, as a whole or of a specific class of neuron in the animal, deviates from that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuron_positioning_abnormal" NARROW [] is_a: WBPhenotype:0000604 ! nervous_system_morphology_variant [Term] id: WBPhenotype:0001311 name: protein_expression_reduced_hermaphrodite def: "Variations that result in a decrease in protein expression in hermaphrodites compared to that observed in control animals. " [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0001312 name: neuron_number_variant def: "The quantity of neuronal cells, as a whole or of a specific class of neuron in the animal deviates from that observed in control animals." [WB:WBPaper00027711, WB:WBPerson712] synonym: "neuron_number_abnormal" NARROW [] is_a: WBPhenotype:0000604 ! nervous_system_morphology_variant [Term] id: WBPhenotype:0001313 name: uterine_muscle_variant def: "Any variation in the progression of the sex-specific muscles of the hermaphrodite, over time, whose contractions squeeze on the uterus to help move eggs towards the vulval opening compared to control (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "uterine_muscle_abnormal" NARROW [] is_a: WBPhenotype:0000282 ! hermaphrodite_sex_muscle_development_variant [Term] id: WBPhenotype:0001314 name: vulval_muscle_variant def: "Any variation in the progression of the sex-specific muscles in the hermaphrodite, over time, that are specialized for egg-laying compared to control. In C. elegans the contractions of the vulval muscles open the lips of the vulva to help in expelling an egg from the uterus (Wormatlas). " [WB:WBPerson2021, WB:WBPerson557] synonym: "vulval_muscle_abnormal" NARROW [] is_a: WBPhenotype:0000282 ! hermaphrodite_sex_muscle_development_variant [Term] id: WBPhenotype:0001315 name: electrophysiology_variant def: "Animals exhibit variations in the electrical properties of any of its cells or tissues compared to control." [WB:WBPerson2021] synonym: "electrophysiology_abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism_physiology_variant [Term] id: WBPhenotype:0001316 name: evoked_postsynaptic_current_variant def: "Variations in the synaptic currents that are elicited by firing an action potential in a population of axons, compared to control." [pmid:14735116, WB:WBPerson2021] synonym: "evoked_postsynaptic_current_abnormal" NARROW [] is_a: WBPhenotype:0001315 ! electrophysiology_variant [Term] id: WBPhenotype:0001317 name: evoked_postsynaptic_amplitude_reduced def: "The amplitudes of synaptic currents that are elicited by firing an action potential in a population of axons are decreased, compared to those observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001316 ! evoked_postsynaptic_current_variant [Term] id: WBPhenotype:0001318 name: endogenous_synaptic_events_variant def: "Any variation in the currents observed in the absence of presynaptic action potentials and that are elicited by fusion of a single endogenous vesicle of transmitter compared to control." [pmid:14735116, WB:WBPerson2021] synonym: "endogenous_synaptic_events_abnormal" NARROW [] is_a: WBPhenotype:0001315 ! electrophysiology_variant [Term] id: WBPhenotype:0001319 name: endogenous_synaptic_event_frequency_reduced def: "The rate (frequency) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is decreased compared to control. Changes in frequency are indicative of presynaptic modifications. " [pmid:14735116, WB:WBPaper00026938, WB:WBPerson2021] is_a: WBPhenotype:0001318 ! endogenous_synaptic_events_variant [Term] id: WBPhenotype:0001320 name: endogenous_synaptic_amplitude_variant def: "The amplitude (magnitude) of currents elicited by fusion of a single endogenous vesicle of transmitter in the absence of presynaptic action potentials is altered compared to control. Changes in amplitude are often interpreted as alterations of postsynaptic responsiveness to the transmitter. " [pmid:14735116, WB:WBPerson2021] synonym: "endogenous_synaptic_amplitude_abnormal" NARROW [] is_a: WBPhenotype:0001318 ! endogenous_synaptic_events_variant [Term] id: WBPhenotype:0001321 name: presynaptic_region_morphology_variant def: "Animals display variations in the structure, configuration, distribution or ratio of the components of the vesicle-filled varicosities of the synapse compared to control." [GO:0042734, WB:WBPaper00000938, WB:WBPaper00027305, WB:WBPaper00028886, WB:WBPerson712] synonym: "presynaptic_region_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000616 ! synapse_morphology_variant [Term] id: WBPhenotype:0001322 name: vesicle_number_reduced def: "Total presynaptic vesicle number is reduced, possibly refecting a defect in the replenishment of synaptic vesicles compared to control." [pmid:16803962, WB:cab] comment: Electron microscopic analysis is_a: WBPhenotype:0001332 ! vesicle_number_variant [Term] id: WBPhenotype:0001323 name: vesicle_morphology_variant def: "Animals display variations in the shape or size of their vesicles, which are spherical, membrane-bound fluid-filled organelles, compared to vesicles observed in control animals." [GO:0031982, pmid:16803962, WB:cab, WB:WBPaper00027612, WB:WBPaper00027711, WB:WBPerson712] comment: Electron microscopic analysis synonym: "vesicle_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0001671 ! vesicle_organization_variant [Term] id: WBPhenotype:0001324 name: cell_ionizing_radiation_response_variant def: "Cells exhibit variations in their response to ionizing radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "cell_ionizing_radiation_response_abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell_stress_response_variant [Term] id: WBPhenotype:0001325 name: backing_not_sustained def: "Animals initiate but do not continue backward movement, similar to control animals." [WB:cab, WB:cgc914] is_a: WBPhenotype:0001005 ! backward_locomotion_variant [Term] id: WBPhenotype:0001326 name: cell_gamma_ray_response_variant def: "Cells exhibit variations in their response to gamma ray radiation compared to that observed in control animals." [WB:WBPerson557] synonym: "cell_gamma_ray_response_abnormal" NARROW [] is_a: WBPhenotype:0001324 ! cell_ionizing_radiation_response_variant [Term] id: WBPhenotype:0001327 name: cell_gamma_ray_hypersensitive def: "Cells respond to a lower dosage of gamma rays or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001326 ! cell_gamma_ray_response_variant [Term] id: WBPhenotype:0001328 name: posterior_body_dumpy def: "The posterior part of the worm is shorter and stouter compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000793 ! posterior_body_morphology_variant [Term] id: WBPhenotype:0001329 name: curly def: "Animals exhibit a greater number of bends in their body compared to control. C. elegans posture assumes more than a single sine wave." [WB:cab, WB:cgc914] is_a: WBPhenotype:0000001 ! body_posture_variant [Term] id: WBPhenotype:0001330 name: egg_laying_event_infrequent def: "The rate of the intrinsic behavioral program that serves to move fertilized eggs down the uterus, through the vulva, and out of the worm onto the substrate is reduced compared to that observed in control animals (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "egg_laying_event_rare" RELATED [] is_a: WBPhenotype:0000006 ! egg_laying_defective is_a: WBPhenotype:0000272 ! egg_laying_irregular [Term] id: WBPhenotype:0001331 name: motor_neuron_morphology_variant def: "Animals display variations in the structure or organization of components of the motor neuron, internal to the cell itself or in relation to the cellular environment compared to that observed in control animals. A motor neuron is a neuronal cell that synapses to an effector (muscle, gland etc.)." [WB:WBPerson712] comment: WBbt:0005409 synonym: "motor_neuron_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000905 ! neuron_morphology_variant [Term] id: WBPhenotype:0001332 name: vesicle_number_variant def: "Animals display variations in the number of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "vesicle_number_abnormal" NARROW [] is_a: WBPhenotype:0001671 ! vesicle_organization_variant [Term] id: WBPhenotype:0001333 name: neuron_cell_body_absent_misplaced def: "The body of a neuron is not where it should be when compared to control animals; it is absent or misplaced." [WB:WBPaper00000502, WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0000816 ! neuron_development_variant [Term] id: WBPhenotype:0001334 name: hermaphrodite_sex_muscle_morphology_variant def: "Any variation in the form, structure or composition of the muscles of the adult hermaphrodite reproductive system compared to control. In C. elegans hermaphrodites these muscles include the vulval and uterine muscles, located near the vulva in the midbody, which all derive from the M myoblast (Wormatlas).\n" [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite_sex_muscle_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0001335 ! hermaphrodite_reproductive_system_morphology_variant [Term] id: WBPhenotype:0001335 name: hermaphrodite_reproductive_system_morphology_variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the hermaphrodite reproductive system, compared to control. The reproductive system is involved in the generation of progeny which contain genetic material inherited from the parents." [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite_reproductive_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000605 ! reproductive_system_morphology_variant [Term] id: WBPhenotype:0001336 name: male_mating_efficiency_eliminated def: "Males sire no cross progeny." [WB:WBPaper00000179, WB:WBPaper00000608, WB:WBPerson557] synonym: "no_male_progeny" EXACT [] is_a: WBPhenotype:0000843 ! male_mating_efficiency_reduced [Term] id: WBPhenotype:0001337 name: adrenergic_receptor_antagonist_response_variant def: "Animals exhibit variations in their response to a specific adrenergic receptor antagonist compared to that observed in control animals." [WB:WBPerson557] synonym: "adrenergic_receptor_antagonist_response_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001338 name: phentolamine_resistant def: "Animals fail to respond to the concentration of phentolamine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001337 ! adrenergic_receptor_antagonist_response_variant [Term] id: WBPhenotype:0001339 name: egg_laying_levamisole_resistant def: "Animals are not induced to lay eggs in reponse to exogenous levamisole. In C. elegans, levamisole stimulates egg-laying." [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0000421 ! levamisole_resistant is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_variant [Term] id: WBPhenotype:0001340 name: egg_laying_imipramine_resistant def: "Animals are not induced to lay eggs in reponse to exogenous imipramine. In C. elegans, imipramine stimulates egg-laying." [WB:WBPaper00000635, WB:WBPaper00001133, WB:WBPaper00031293, WB:WBPerson712] is_a: WBPhenotype:0000340 ! imipramine_resistant is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_variant [Term] id: WBPhenotype:0001341 name: egg_laying_phentolamine_resistant def: "Animals are not induced to lay eggs in reponse to exogenous phentolamine. In C. elegans, phentolamine stimulates egg-laying." [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_variant is_a: WBPhenotype:0001338 ! phentolamine_resistant [Term] id: WBPhenotype:0001342 name: egg_laying_imipramine_hypersensitive def: "Animals respond to exogenous imipramine at a lower concentration or within a shorter time period than control animals under the same conditions." [WB:WBPaper00000635, WB:WBPerson712] is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_variant [Term] id: WBPhenotype:0001343 name: meiotic_spindle_defective_early_emb def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a meiotic cell cycle." [GO:0000212, WB:WBPerson2021] comment: Possible XP synonym: "meiotic_spindle_abnormal" NARROW [] is_a: WBPhenotype:0000759 ! spindle_defective_early_emb [Term] id: WBPhenotype:0001344 name: organelle_organization_biogenesis_variant def: "Intracellular membrane bound compartments vary in shape or size from that observed in control animals." [WB:WBPaper00032168, WB:WBPerson712] synonym: "organelle_organization_biogenesis_abnormal" NARROW [] is_a: WBPhenotype:0010002 ! cell_organization_biogenesis_variant [Term] id: WBPhenotype:0001345 name: cytoskeleton_organization_biogenesis_variant def: "Animals exhibit variations in the form, structure, composition or arrangement of any of the various filamentous elements that form the internal framework of cells, compared to control. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GO:0005856, WB:WBPerson2021, WB:WBPerson557] synonym: "cytoskeleton_organization_biogenesis_abnormal" NARROW [] is_a: WBPhenotype:0001344 ! organelle_organization_biogenesis_variant [Term] id: WBPhenotype:0001346 name: actin_cytoskeleton_dynamics_variant def: "Any variation in the dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins compared to control. " [GO:0031532, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "actin_cytoskeleton_dynamic_abnormal" NARROW [] is_a: WBPhenotype:0001587 ! actin_organization_biogenesis_variant [Term] id: WBPhenotype:0001347 name: intestinal_calcium_signaling_variant def: "Any variation in the series of molecular signals in which an intestinal cell uses calcium ions to convert an extracellular signal into a response, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "intestinal_calcium_signaling_abnormal" NARROW [] is_a: WBPhenotype:0001093 ! intestinal_physiology_variant [Term] id: WBPhenotype:0001348 name: chromosome_morphology_variant def: "Variations in the form or composition of a structure in the cell nucleus which contains the genetic material encoded as DNA and surrounded by histone proteins and other regulatory elements compared to control. In C. elegans the normal cell contains 5 pairs of 'autosomes' and one or two X chromosomes (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "chromosome_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0001028 ! nuclear_appearance_variant [Term] id: WBPhenotype:0001349 name: protein_phosphorylation_variant def: "Variations in the processes that incorporate phosphate groups to one or more amino acids within a protein, compared to control." [GO:0006468, WB:WBPerson2021] synonym: "protein_phosphorylation_abnormal" NARROW [] is_a: WBPhenotype:0001382 ! protein_modification_variant [Term] id: WBPhenotype:0001350 name: protein_phosphorylation_increased def: "Animals exhibit higher levels of protein phosphorylation compared to that observed in control animals. " [WB:WBPerson2021] is_a: WBPhenotype:0001349 ! protein_phosphorylation_variant [Term] id: WBPhenotype:0001351 name: protein_phosphorylation_reduced def: "Animals exhibit decreased levels of protein phosphorylation compared to that observed in control animals. " [WB:WBPerson2021] is_a: WBPhenotype:0001349 ! protein_phosphorylation_variant [Term] id: WBPhenotype:0001352 name: endoplasmic_reticulum_metabolism_variant def: "Variations in the chemical reactions and pathways of the endoplasmic reticulum compared to control." [WB:WBPerson2021] synonym: "endoplasmic_reticulum_metabolism_abnormal" NARROW [] synonym: "er_metabolism_abnormal" RELATED [] is_a: WBPhenotype:0001283 ! organelle_metabolism_variant [Term] id: WBPhenotype:0001353 name: centration_defective_early_emb def: "The coordinated movement during prophase of the two centrosomes and the two pronuclei towards the center of the one cell embryo is abolished." [WB:WBPaper00027230, WB:WBPerson2021, WB:WBPerson557] synonym: "centration_abnormal" NARROW [] is_a: WBPhenotype:0001152 ! pronuclear_migration_defective_early_emb [Term] id: WBPhenotype:0001354 name: actin_cytoskeleton_filament_morphology_variant def: "Animals exhibit variations in the form, structure, composition or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "actin_cytoskeleton_filament_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001587 ! actin_organization_biogenesis_variant [Term] id: WBPhenotype:0001355 name: gonad_morphology_variant def: "Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male or female gametes compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "gonad_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000605 ! reproductive_system_morphology_variant [Term] id: WBPhenotype:0001356 name: male_sex_muscle_morphology_variant def: "Any variation in the form, structure or composition of the muscles of the adult male reproductive system compared to control. In C. elegans males, the M myoblast gives rise to a much larger set of specialized muscles, compared to hermaphrodites, which differentiate within the tail region (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_sex_muscle_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001024 ! male_morphology_variant [Term] id: WBPhenotype:0001357 name: male_gonad_morphology_variant def: "Variations in the form or composition of a specialized tissue of the reproductive tract that produces the male gametes compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_gonad_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001024 ! male_morphology_variant [Term] id: WBPhenotype:0001358 name: male_nervous_system_morphology_variant def: "Male animals exhibit variations in the structure or organization of any component that is part of the complement of organ tissues that serve to detect, relay and coordinate information about an animal's internal and external environments and to initiate and integrate its effector responses and activities, compared to that in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_nervous_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001024 ! male_morphology_variant [Term] id: WBPhenotype:0001359 name: proctodeum_morphology_variant def: "Animals exhibit variations in the structure and organization of the chamber in the male tail that extends from the termination of four canals (vas deferens, gut, and left and right spicule channels) to just before the cloaca, from that observed in control animals." [WB:WBPaper00027278, WB:WBPerson712] synonym: "proctodeum_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000070 ! male_tail_morphology_variant [Term] id: WBPhenotype:0001360 name: hermaphrodite_self_sterile def: "Hermaphrodites fail to produce any viable progeny via self-fertilization. However, such hermaphrodites can successfully reproduce if mated to control males." [WB:WBPaper00001075, WB:WBPerson2021] is_a: WBPhenotype:0000694 ! hermaphrodite_sterile [Term] id: WBPhenotype:0001361 name: chromosome_condensation_variant def: "Any variation in the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells compared to control." [GO:0030261, WB:WBPerson2021, WB:WBPerson557] synonym: "chromosome_condensation_abnormal" NARROW [] is_a: WBPhenotype:0000775 ! meiosis_variant [Term] id: WBPhenotype:0001362 name: chromosome_condensation_failure def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis in eukaryotic cells is abolished." [GO:0030261, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001361 ! chromosome_condensation_variant [Term] id: WBPhenotype:0001363 name: head_cavity def: "The head contains cavities, possibly indicative of inappropriate cell death." [WB:cab] synonym: "head_vacuole" RELATED [] is_a: WBPhenotype:0000071 ! head_morphology_variant [Term] id: WBPhenotype:0001364 name: male_fan_morphology_variant def: "Any variation in the form, structure or composition of the flattened structure extending laterally at the extreme tip of the adult male consisting of nine pairs of sensory rays that lie within a web-like cuticle compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "male_fan_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000070 ! male_tail_morphology_variant [Term] id: WBPhenotype:0001365 name: male_bursa_development_variant def: "Any variation in the process whose specific outcome is the progression of the male bursa over time, from its formation to the mature structure, compared to control." [WB:WBPerson2021] synonym: "male_bursa_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0001297 ! male_tail_development_variant [Term] id: WBPhenotype:0001366 name: male_fan_development_variant def: "Any variation in the process whose specific outcome is the progression of the male fan over time, from its formation to the mature structure, compared to control." [WB:WBPerson2021] synonym: "male_fan_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0001297 ! male_tail_development_variant [Term] id: WBPhenotype:0001367 name: proctodeum_development_variant def: "Any variation in the process whose specific outcome is the progression of the male proctodeum over time, from its formation to the mature structure, compared to control. The union of the vas deferens and the intestine give rise to the proctodeum which contains copulatory spicules." [WB:WBPerson2021] synonym: "proctodeum_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0001297 ! male_tail_development_variant [Term] id: WBPhenotype:0001368 name: spermatheca_absent def: "Animals lack the somatic gonad structure that connects the distal gonad arm to the uterus." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001662 ! spermatheca_development_variant [Term] id: WBPhenotype:0001369 name: protein_interaction_variant def: "Variations in the selective and non-covalent physical association between two or more proteins, or a protein and nucleic acid/macromolecular complex, compared to control." [GO:0005515, WB:WBPerson2021] synonym: "protein_interaction_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0001370 name: protein_protein_interaction_variant def: "Variations in the selective and non-covalent physical association between two or more proteins, compared to control." [WB:WBPerson2021] synonym: "protein_protein_interaction_abnormal" NARROW [] is_a: WBPhenotype:0001369 ! protein_interaction_variant [Term] id: WBPhenotype:0001371 name: protein_RNA_interaction_variant def: "Variations in the selective and non-covalent physical association between a protein and a specific RNA sequence, compared to control." [WB:WBPerson2021] synonym: "protein_RNA_interaction_abnormal" NARROW [] is_a: WBPhenotype:0001369 ! protein_interaction_variant [Term] id: WBPhenotype:0001372 name: protein_DNA_interaction_variant def: "Variations in the selective and non-covalent physical association between a protein and a specific DNA sequence, compared to control." [WB:WBPerson2021] synonym: "protein_DNA_interaction_abnormal" NARROW [] is_a: WBPhenotype:0001369 ! protein_interaction_variant [Term] id: WBPhenotype:0001373 name: protein_rna_interaction_abolished def: "Animals lack a specific protein-RNA interaction observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001371 ! protein_RNA_interaction_variant [Term] id: WBPhenotype:0001374 name: pronuclear_nuclear_appearance_variant_emb def: "The shape and size of nuclei as well as the distribution of nucleoporins are strongly affected." [WB:cab, WB:WBPaper00028895] synonym: "Pna" RELATED [] synonym: "pronuclear_nuclear_appearance_abnormal" NARROW [] is_a: WBPhenotype:0000764 ! embryonic_cell_organization_biogenesis_variant [Term] id: WBPhenotype:0001375 name: transgene_expression_undetectable def: "The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection." [WB:WBPerson557] is_a: WBPhenotype:0001278 ! transgene_expression_reduced [Term] id: WBPhenotype:0001376 name: transgene_expression_undetectable_cell_specific def: "The expression of a gene product produced by DNA coded for by exogenous genetic material that has been introduced into the organism is reduced below the threshold of detection in specific cells." [WB:WBPerson557] is_a: WBPhenotype:0001375 ! transgene_expression_undetectable [Term] id: WBPhenotype:0001377 name: break_induced_focus_formation_variant def: "Variations in the generation of foci that mark crossover recombination events, compared to control. These foci mark the boundary of asymmetric synaptonemal complex disassembly." [WB:WBPaper00032296, WB:WBPerson2021, WB:WBPerson557] synonym: "break_induced_focus_formation_abnormal" NARROW [] is_a: WBPhenotype:0001256 ! DNA_damage_induced_focus_formation_variant is_a: WBPhenotype:0001324 ! cell_ionizing_radiation_response_variant [Term] id: WBPhenotype:0001378 name: mitotic_chromosome_segregation_variant def: "Any variation in the cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle compared to control animals." [GO:0000070, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "mitotic_chromosome_segregation_abnormal" NARROW [] is_a: WBPhenotype:0000773 ! chromosome_segregation_variant [Term] id: WBPhenotype:0001379 name: organism_toxic_chemical_response_variant def: "Animals exhibit variations in their response to a specific toxic chemical compared to that observed in control animals." [WB:WBPerson557] synonym: "organism_toxic_chemical_response_abnormal" NARROW [] is_a: WBPhenotype:0000523 ! chemical_response_variant [Term] id: WBPhenotype:0001380 name: anoxia_hypersensitive def: "Animals respond to anoxic (low or trace oxygen levels) stress after a shorter exposure time compared to control." [WB:WBPerson2021] synonym: "hypoxia_hypersensitive" RELATED [] is_a: WBPhenotype:0000464 ! oxygen_response_variant [Term] id: WBPhenotype:0001381 name: anoxia_resistant def: "Animals fail to respond to low or trace amounts of oxygen that elicit a response in control animals." [WB:WBPerson2021] synonym: "hypoxia_resistant" RELATED [] is_a: WBPhenotype:0000464 ! oxygen_response_variant [Term] id: WBPhenotype:0001382 name: protein_modification_variant def: "Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GO:0006464, WB:WBPerson2021] synonym: "protein_modification_abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein_expression_variant [Term] id: WBPhenotype:0001383 name: protein_methylation_variant def: "Variations in the processes that incorporate methyl groups to one or more amino acids within a protein, compared to control." [GO:0006479, WB:WBPerson2021] synonym: "protein_methylation_abnormal" NARROW [] is_a: WBPhenotype:0001382 ! protein_modification_variant [Term] id: WBPhenotype:0001384 name: fertility_reduced def: "Animals exhibit a reduction in the production of new individuals that contain some portion of their genetic material inherited from that organism as a result of defective gametes." [GO:0000003, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000145 ! fertility_variant [Term] id: WBPhenotype:0001385 name: precocious_oogenesis def: "Relatively unspecialized germ cells prematurely acquire the specialized properties of mature oocytes." [WB:WBPaper00001475, WB:WBPaper00028819, WB:WBPerson2021] is_a: WBPhenotype:0000186 ! oogenesis_variant [Term] id: WBPhenotype:0001386 name: fertilization_defective_hermaphrodite def: "Any perturbation that disrupts the fusion of male and female gametes (sperm and oocyte) in adult hermaphrodites during sexual reproduction." [WB:WBPerson2021] is_a: WBPhenotype:0000983 ! fertilization_defective [Term] id: WBPhenotype:0001387 name: fertilization_defect_male def: "Failure of male-derived sperm to fuse with an oocyte during sexual reproduction." [WB:WBPaper00033007, WB:WBPerson2021] is_a: WBPhenotype:0000983 ! fertilization_defective [Term] id: WBPhenotype:0001388 name: organism_hypersensitive_gamma_irradiation def: "Organisms respond to a lower dosage of gamma rays or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000497 ! organism_gamma_ray_response_variant is_a: WBPhenotype:0000711 ! organism_hypersensitive_ionizing_radiation [Term] id: WBPhenotype:0001389 name: cell_gamma_ray_resistant def: "Cells fail to respond to the dosage of gamma irradiation that elicits a response in control animals. Alternatively, cells require longer exposure times to gamma irradiation to mimic the response observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001326 ! cell_gamma_ray_response_variant [Term] id: WBPhenotype:0001390 name: cell_UV_hypersensitive def: "Cells respond to a lower dosage of UV or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000100 ! cell_UV_response_variant [Term] id: WBPhenotype:0001391 name: gamma_ray_induced_apoptosis_increased def: "Animals exhibit an increase in the extent of activation of programmed cell death by exposure to the nucleic acid damaging agent, gamma irradiation, compared to control." [WB:WBPerson712] is_a: WBPhenotype:0000183 ! apoptosis_increased is_a: WBPhenotype:0001326 ! cell_gamma_ray_response_variant [Term] id: WBPhenotype:0001392 name: cell_cycle_arrest def: "Cells of the animals cease during one of its replicative phases (G1, S, G2, M)." [GO:0007050, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000740 ! cell_cycle_variant [Term] id: WBPhenotype:0001393 name: cell_acidification_variant def: "Variations in the processes that reduce the internal pH of a cell (measured by the concentration of the hydrogen ion), compared to control." [GO:0045851, WB:WBPerson2021] synonym: "cell_acidification_abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001394 name: cell_acidification_defective def: "Animals lack the capacity to reduce the internal pH of a cell." [GO:0045851, WB:WBPerson2021] synonym: "no_pumping" RELATED [] is_a: WBPhenotype:0001393 ! cell_acidification_variant [Term] id: WBPhenotype:0001395 name: body_vacuole def: "Vacuoles accumulate in the body. A vacuole is a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GO:0005776, WB:WBPerson557] is_a: WBPhenotype:0000072 ! body_morphology_variant [Term] id: WBPhenotype:0001396 name: pumping_absent def: "Animals completely lack any pharyngeal pumping motion." [WB:WBPaper00001894, WB:WBPerson2021] is_a: WBPhenotype:0001006 ! pharyngeal_pumping_rate_variant [Term] id: WBPhenotype:0001397 name: necrotic_cell_death_increased def: "Animals exhibit an increase in the cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents, compared to control." [GO:0070265, WB:WBPerson712] is_a: WBPhenotype:0000415 ! necrotic_cell_death_variant [Term] id: WBPhenotype:0001398 name: neurite_morphology_variant def: "Animals display variations in the structure, organization of components, or spatial pattern of any projection stemming from a neuronal cell, compared to that observed in control animals." [GO:0043005, WB:WBPaper00028886, WB:WBPerson712] synonym: "neurite_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000905 ! neuron_morphology_variant [Term] id: WBPhenotype:0001399 name: cell_membrane_morphology_variant def: "Any variation in the structure, form or composition of the semipermeable lipid bilayer that creates a boundary between the interior and exterior environment for cells, cellular organelles and tissues, within an organism compared to control. " [GO:0005886, WB:WBPerson2021, WB:WBPerson557] synonym: "cell_membrane_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0001400 name: level_of_protein_expression_variant def: "Animals exhibit variations in the measured expression of a protein compared to that observed in control animals." [WB:WBPerson2021] synonym: "level_of_protein_expression_abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein_expression_variant [Term] id: WBPhenotype:0001401 name: mitochondria_morphology_variant def: "The morphological appearance of mitochondria is varied compared to control animals." [WB:cab] synonym: "mitochondria_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0001402 name: connected_mitochondria def: "Mitochondria are interconnected by thin tubules of mitochondrial inner or outer membrane." [GO:0007006, WB:WBPaper00032231, WB:WBPerson712] is_a: WBPhenotype:0001401 ! mitochondria_morphology_variant [Term] id: WBPhenotype:0001403 name: antibody_subcellular_localization_variant def: "Any variation in the placement of a protein, as detected by antibody staining, within in a cell or cellular compartment compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "antibody_subcellular_localization_abnormal" NARROW [] is_a: WBPhenotype:0000424 ! antibody_staining_variant [Term] id: WBPhenotype:0001404 name: ectopic_expression_antibody def: "Any variation that results in the detection of protein expression in cells/tissues through antibody staining, that is otherwise not observed in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000424 ! antibody_staining_variant [Term] id: WBPhenotype:0001405 name: protein_aggregation_variant def: "Variations that result in the accumulation of soluble/insoluble protein aggregates in a particular cell or tissue, compared to control. Protein aggregates are often formed by interactions between misfolded protein molecules and/or deficiencies in proper protein folding." [WB:WBPaper00034765, WB:WBPerson2021] synonym: "protein_aggregation_abnormal" NARROW [] is_a: WBPhenotype:0001370 ! protein_protein_interaction_variant [Term] id: WBPhenotype:0001406 name: protein_expression_reduced_male def: "Variations that result in a decrease in protein expression in male animals compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0001407 name: protein_expression_reduced_cell_specific def: "Variations that result in a decrease in protein expression in specific cells compared to that observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0001408 name: pattern_protein_expression_variant def: "Any variation in the cellular or subcellular distribution of a protein compared to that observed in control animals." [WB:WBPerson2021] synonym: "pattern_protein_expression_abnormal" NARROW [] is_a: WBPhenotype:0000112 ! protein_expression_variant [Term] id: WBPhenotype:0001409 name: protein_expression_ectopic def: "Any variation that results in the cellular expression of a protein in cells/tissues, that is otherwise not observed in control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001408 ! pattern_protein_expression_variant [Term] id: WBPhenotype:0001410 name: protein_expression_absent def: "Animals fail to express a given protein or class of proteins." [WB:WBPerson2021] is_a: WBPhenotype:0000120 ! protein_expression_reduced [Term] id: WBPhenotype:0001411 name: cuticle_carbohydrate_surface_variant def: "Animals exhibit an altered display of glycosylated proteins or lipids or altered access to glycosylated moieties along their surface from that observed in control animals of the same developmental stage. In C. elegans, variations in surface accessible glycosylated species are often revealed by altered lectin-binding from that observed in control animals." [WB:WBPaper00001576, WB:WBPerson712] synonym: "cuticle_carbohydrate_surface_abnormal" NARROW [] synonym: "ectopic_lectin_binding" RELATED [] synonym: "Srf" NARROW [] is_a: WBPhenotype:0001687 ! surface_antigenicity_variant [Term] id: WBPhenotype:0001412 name: alae_morphology_variant def: "Animals exhibit variations in the organization of the longitudinal ridges on the cuticle along the length of the animal, from that observed for control animals of the same developmental stage." [WB:WBPaper00000465, WB:WBPaper00031415, WB:WBPerson712] synonym: "alae_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0000948 ! cuticle_morphology_variant [Term] id: WBPhenotype:0001413 name: bacterially_unswollen def: "Animals do not exhibit tail-swelling in response to infection by a bacterial pathogen (such as Microbacterium nematophilum) compared to control." [WB:cab, WB:WBPaper00026735] synonym: "Bus" BROAD three_letter_name [] is_a: WBPhenotype:0000073 ! tail_morphology_variant is_a: WBPhenotype:0001014 ! pathogen_resistance_increased [Term] id: WBPhenotype:0001414 name: male_mating_defective def: "Males exhibit defects in the specific actions or reactions that are associated with reproduction." [GO:0060179, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000648 ! male_mating_variant [Term] id: WBPhenotype:0001415 name: pathogen_adherence_variant def: "Animals exhibit variations that result in pathogens not being able to adhere to the surface compared to control." [WB:cab, WB:WBPaper00026735] synonym: "pathogen_adherence_abnormal" NARROW [] is_a: WBPhenotype:0001012 ! organism_pathogen_response_variant [Term] id: WBPhenotype:0001416 name: pathogen_adherence_defect def: "Pathogens are unable to adhere/colonize the surface of host animals. This defect is often associated with changes in cuticle surface properties of the host. " [WB:WBPaper00028877, WB:WBPerson2021] is_a: WBPhenotype:0001014 ! pathogen_resistance_increased is_a: WBPhenotype:0001415 ! pathogen_adherence_variant [Term] id: WBPhenotype:0001417 name: organism_dessication_response_variant def: "Any variation in the state or activity of an organism in response to extreme dryness or drought-like conditions, compared to control ." [GO:0009819, WB:WBPerson2021] synonym: "organism_dessication_response_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0001418 name: organism_hypersensitive_dessication def: "Animals respond to less severe drought-like conditions or a shorter exposure compared to control animals. " [WB:WBPerson2021] is_a: WBPhenotype:0001417 ! organism_dessication_response_variant [Term] id: WBPhenotype:0001419 name: emetine_hypersensitive def: "Animals respond to emetine at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0001420 name: biofilm_absent_head def: "Animals can move thorough a lawn of bacterially produced biofilm without accumulating an enormous amount of biofilm on its nose. When C. elegans is exposed to certain bacteria ( e.g., Y. pestis), a biofilm accumulates on a worm's head. The presence of this biofilm inhibits feeding by the worm, and thereby prevents growth." [WB:cab, WB:WBPaper00005238] synonym: "Bah" BROAD three_letter_name [] is_a: WBPhenotype:0001415 ! pathogen_adherence_variant [Term] id: WBPhenotype:0001421 name: endocytic_transport_variant def: "Animals exhibit variations in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks newly ingested material to different compartments of the cell or back to the plasma membrane for recycling compared to control." [GO:0016197, WB:WBPaper00031894, WB:WBPerson712] synonym: "endocytic_transport_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0001422 name: endocytic_transport_defect def: "Animals exhibit defects in the directed movement of substances into, out of or mediated by the endosome, a membrane-bound organelle that trafficks newly ingested material to different compartments of the cell or back to the plasma membrane for recycling." [GO:0016197, WB:WBPerson557] is_a: WBPhenotype:0001421 ! endocytic_transport_variant [Term] id: WBPhenotype:0001423 name: coelomocyte_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the coelomocyte to carry out its normal functions or activities, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "coelomocyte_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0001424 name: oocyte_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the oocyte to carry out its normal functions or activities, compared to control animals." [GO:0009987, WB:WBPerson557, WB:WBPerson712] synonym: "oocyte_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0001425 name: receptor_mediated_endocytosis_defective def: "Animals exhibit defects in the cell-mediated uptake of external materials via receptor activity. Receptor-mediated endocytosis ensures specificity of transport and generally occurs via clathrin-coated pits and vesicles. In C. elegans, this is often judged by the lack of yolk uptake in oocytes." [GO:0006898, pmid:16042554, WB:cab, WB:WBPerson2021] comment: possible XP= GO:0006898 synonym: "Rme" RELATED [] is_a: WBPhenotype:0001422 ! endocytic_transport_defect is_a: WBPhenotype:0001424 ! oocyte_physiology_variant [Term] id: WBPhenotype:0001426 name: coelomocyte_uptake_defective def: "Fluid-phase endocytosis by coelomocytes is less frequent or efficient compared to control." [pmid:16042554, WB:cab] synonym: "Cup" RELATED [] is_a: WBPhenotype:0001422 ! endocytic_transport_defect is_a: WBPhenotype:0001423 ! coelomocyte_physiology_variant [Term] id: WBPhenotype:0001427 name: cytoplasmic_appearance_variant def: "Animals exhibit variations in the form, structure or composition of any cellular contents (excluding plasma membrane and nucleus), compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "cytoplasmic_appearance_abnormal" NARROW [] is_a: WBPhenotype:0010002 ! cell_organization_biogenesis_variant [Term] id: WBPhenotype:0001428 name: intestinal_vacuole def: "Vacuoles accumulate in the intestine." [WB:WBPaper00004718, WB:WBPaper00031894, WB:WBPerson712] is_a: WBPhenotype:0000710 ! intestinal_morphology_variant [Term] id: WBPhenotype:0001429 name: granules_cytoplasm def: "Animals accumulate an excess of vesicle-like structures in cells." [pmid:17203072, WB:cab] is_a: WBPhenotype:0001427 ! cytoplasmic_appearance_variant [Term] id: WBPhenotype:0001430 name: lysosome_organization_biogenesis_variant def: "Variations in the processes that are carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome, compared to control." [GO:0007040, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "lysosome_organization_biogenesis_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0001431 name: pointed_tail_tip_male alt_id: WBPhenotype:0000967 def: "Male tails fail to undergo tip retraction thereby forming a 'leptoderan' or 'pointed' adult tail." [WB:WBPerson2021, WB:WBPerson557] synonym: "Lep" BROAD three_letter_name [] synonym: "leptoderan_tail" RELATED [] synonym: "male_tail_spike" EXACT [] is_a: WBPhenotype:0000070 ! male_tail_morphology_variant [Term] id: WBPhenotype:0001432 name: over_retracted_male_tail def: " Adult males exhibit a truncated tail, often without a fan or have well-developed fans but squarish, truncated back ends compared to control. In C. elegans this is due to precocious male tail tip retraction beginning in the early L3 stage (normally retraction begins in the L4 stage). Condition can be lethal if the function of the anus is affected." [pmid:16806150, WB:cab] synonym: "Ore" BROAD three_letter_name [] is_a: WBPhenotype:0000070 ! male_tail_morphology_variant is_a: WBPhenotype:0001297 ! male_tail_development_variant [Term] id: WBPhenotype:0001433 name: precocious_cell_fusion def: "Two or more individual cells form a syncytium (a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane) via the fusion of the plasma membranes at an earlier stage of development compared to comparable cells in control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000165 ! cell_fusion_variant [Term] id: WBPhenotype:0001434 name: chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific chemical concentration gradient compared to control. Directed movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GO:0006935, WB:cab] synonym: "chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001040 ! chemosensory_response_variant [Term] id: WBPhenotype:0001435 name: ammonium_chloride_chemotaxis_defective def: "Failure in directed movement in response to ammonium chloride compared to control. In C. elegans, NH4Cl is an attractant. NH4Cl has also subsequently been used to assay for Cl- attraction in C. elegans." [WB:WBPaper00002087, WB:WBPaper00004609, WB:WBPaper00026812] synonym: "chloride chemotaxis defective" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001460 ! ammonium_chloride_chemotaxis_variant [Term] id: WBPhenotype:0001436 name: nose_touch_hypersensitive def: "Animals tend to initiate a response more often, compared to control, after nose-on collisions with an object. In C. elegans, animals initiate backwards movement in response to nose touch." [WB:WBPaper00028963, WB:WBPerson557] is_a: WBPhenotype:0004026 ! nose_touch_variant [Term] id: WBPhenotype:0001437 name: octanol_chemotaxis_hypersensitive def: "Animals execute a response, via directed movement to octanol at a lower concentration or shorter exposure time compared to control. In C. elegans, animals avoid octanol." [WB:WBPaper00028963] is_a: WBPhenotype:0001452 ! octanol_chemotaxis_variant [Term] id: WBPhenotype:0001438 name: odorant_positive_chemotaxis_defective def: "Animals fail to move towards attractive volatile organic molecules. In C. elegans, these compounds are sensed by the AWA and AWC neurons." [WB:WBPerson2021] is_a: WBPhenotype:0000015 ! positive_chemotaxis_defective is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_variant [Term] id: WBPhenotype:0001439 name: anion_positive_chemotaxis_defective def: "Animals fail to move towards attractive anions." [WB:WBPaper00002033, WB:WBPaper00028386] is_a: WBPhenotype:0001052 ! anion_positive_chemotaxis_variant is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective [Term] id: WBPhenotype:0001440 name: cation_positive_chemotaxis_defective def: "Animals fail to move towards attractive cations." [WB:WBPaper00004609] is_a: WBPhenotype:0001051 ! cation_positive_chemotaxis_variant is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective [Term] id: WBPhenotype:0001441 name: aqueous_positive_chemotaxis_defective def: "Animals fail to move towards attractive water-soluble chemicals." [WB:WBPerson2021] synonym: "water_soluble_positive_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000015 ! positive_chemotaxis_defective is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_variant [Term] id: WBPhenotype:0001442 name: sodium_acetate_chemotaxis_defective def: "Failure in directed movement in response to sodium acetate. In C. elegans, sodium acetate is an attractant. Sodium acetate has also subsequently been used to assay for Na+ attraction in C. elegans." [WB:WBPaper00000650, WB:WBPaper00004609, WB:WBPaper00006394] synonym: "sodium chemotaxis defective" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective is_a: WBPhenotype:0001461 ! sodium_acetate_chemotaxis_variant [Term] id: WBPhenotype:0001443 name: aqueous_chemosensory_response_variant def: "Animals exhibit variations in response to water-soluble chemicals, compared to control." [WB:cab] synonym: "aqueous_chemosensory_response_abnormal" NARROW [] synonym: "water_soluble_chemosensory_response_abnormal" RELATED [] is_a: WBPhenotype:0001040 ! chemosensory_response_variant [Term] id: WBPhenotype:0001444 name: aqueous_adaptation_defective def: "Animals do not exhibit characteristic desensitization to a water-soluble chemo-attractive signal in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150] synonym: "aqueous_adaptation_abnormal" NARROW [] synonym: "gustatory_plasticity_abnormal" RELATED [] synonym: "water_soluble_adaptation_abnormal" RELATED [] is_a: WBPhenotype:0001443 ! aqueous_chemosensory_response_variant [Term] id: WBPhenotype:0001445 name: sodium_acetate_adaptation_defective def: "Animals do not exhibit characteristic chemoattractive desensitization to sodium acetate in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150] synonym: "sodium_acetate_adaptation_abnormal" NARROW [] is_a: WBPhenotype:0001444 ! aqueous_adaptation_defective [Term] id: WBPhenotype:0001446 name: sodium_chloride_adaptation_defective def: "Animals do not exhibit characteristic chemoattractive desensitization to sodium chloride in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150] synonym: "sodium_chloride_adaptation_abnormal" NARROW [] is_a: WBPhenotype:0001444 ! aqueous_adaptation_defective [Term] id: WBPhenotype:0001447 name: ammonium_chloride_adaptation_defective def: "Animals do not exhibit characteristic chemoattractive desensitization to ammonium chloride in a time-concentration dependent and reversible manner compared to control." [WB:cab, WB:cgc5150] synonym: "ammonium_chloride_adaptation_abnormal" NARROW [] is_a: WBPhenotype:0001444 ! aqueous_adaptation_defective [Term] id: WBPhenotype:0001448 name: odorant_negative_chemotaxis_defective def: "Animals fail to move away from repellant volatile organic chemicals." [WB:WBPerson2021] synonym: "volatile_negative_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001455 ! odorant_negative_chemotaxis_variant [Term] id: WBPhenotype:0001449 name: aqueous_negative_chemotaxis_defective def: "Animals fail to move away from repellent water soluble chemicals." [WB:WBPerson2021] synonym: "water_soluble_chemotaxis_defective" RELATED [] is_a: WBPhenotype:0001450 ! aqueous_negative_chemotaxis_variant [Term] id: WBPhenotype:0001450 name: aqueous_negative_chemotaxis_variant def: "Animals exhibit variations through directed movement, in response to repellant water soluble chemicals, compared to control." [WB:WBPaper00006481] synonym: "aqueous_negative_chemotaxis_abnormal" NARROW [] synonym: "water_soluble_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000481 ! negative_chemotaxis_variant is_a: WBPhenotype:0001443 ! aqueous_chemosensory_response_variant [Term] id: WBPhenotype:0001451 name: garlic_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of garlic compared to control. In C. elegans, garlic is typically a repellant." [WB:WBPaper00002135, WB:WBPaper00006481, WB:WBPerson557] synonym: "garlic_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001450 ! aqueous_negative_chemotaxis_variant [Term] id: WBPhenotype:0001452 name: octanol_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of octanol. In C. elegans, octanol is typically a repellant." [WB:WBPerson557] synonym: "octanol_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001455 ! odorant_negative_chemotaxis_variant [Term] id: WBPhenotype:0001453 name: high_sodium_chloride_concentration_osmotic_avoidance_variant def: "Animals exhibit variations in their avoidance response to high concentrations of sodium chloride solution compared to control." [WB:WBPerson2021] synonym: "high_sodium_chloride_concentration_osmotic_avoidance_abnormal" NARROW [] is_a: WBPhenotype:0000249 ! osmotic_avoidance_defective [Term] id: WBPhenotype:0001454 name: quinine_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of quinine, a water soluble molecule. In C. elegans, quinine is typically a repellant." [WB:WBPaper00002135, WB:WBPaper00027118, WB:WBPerson557] synonym: "quinine_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001450 ! aqueous_negative_chemotaxis_variant [Term] id: WBPhenotype:0001455 name: odorant_negative_chemotaxis_variant def: "Animals exhibit variations through directed movement, in response to repellant volatile organic chemicals, compared to control." [WB:WBPaper00001786] synonym: "odorant_negative_chemotaxis_abnormal" NARROW [] synonym: "volatile_negative_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000481 ! negative_chemotaxis_variant is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_variant [Term] id: WBPhenotype:0001456 name: nonanone_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of nonanone. In C. elegans, nonanone is typically a repellant." [WB:WBPerson2021, WB:WBPerson557] synonym: "nonanone_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001455 ! odorant_negative_chemotaxis_variant [Term] id: WBPhenotype:0001457 name: bromide_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of bromide. In C. elegans, bromide is typically an attractant." [WB:WBPaper00000387, WB:WBPerson557] synonym: "bromide_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001052 ! anion_positive_chemotaxis_variant [Term] id: WBPhenotype:0001458 name: chloride_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of chloride." [WB:WBPaper00000387] synonym: "ammonium chloride chemotaxis abnormal" RELATED [WB:WBPerson2021] synonym: "chloride_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001052 ! anion_positive_chemotaxis_variant [Term] id: WBPhenotype:0001459 name: iodide_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of iodide." [WB:WBPaper00000387] synonym: "iodide_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001052 ! anion_positive_chemotaxis_variant [Term] id: WBPhenotype:0001460 name: ammonium_chloride_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of ammonium chloride. In C. elegans, at specific concentrations, ammonium chloride is an attractant. NH4Cl has also been used to assay for Cl- attraction." [WB:WBPaper00000387, WB:WBPaper00004609, WB:WBPaper00026812] synonym: "ammonium_chloride_chemotaxis_abnormal" NARROW [] synonym: "chloride chemotaxis abnormal" RELATED [WB:WBPerson2021] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_variant [Term] id: WBPhenotype:0001461 name: sodium_acetate_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium acetate. In C. elegans, at specific concentrations, sodium acetate is an attractant. Sodium acetate has also been used to assay for Na+ attraction." [WB:WBPaper00000387, WB:WBPaper00000650, WB:WBPaper00004609)] synonym: " sodium chemotaxis abnormal" RELATED [WB:WBPerson2021] synonym: "sodium_acetate_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_variant [Term] id: WBPhenotype:0001462 name: sodium_chloride_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of sodium chloride. In C. elegans, at specific concentrations, sodium chloride is an attractant." [WB:WBPaper00000387] synonym: "sodium_chloride_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001047 ! aqueous_positive_chemotaxis_variant [Term] id: WBPhenotype:0001463 name: cAMP_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of cAMP." [GO:0043327, WB:WBPaper00000387] synonym: "cAMP_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001053 ! cyclic_nucleotide_positive_chemotaxis_variant [Term] id: WBPhenotype:0001464 name: cGMP_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of cGMP." [WB:WBPaper00000387] synonym: "cGMP_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001053 ! cyclic_nucleotide_positive_chemotaxis_variant [Term] id: WBPhenotype:0001465 name: acetone_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of acetone. In C. elegans, at specific concentrations, acetone is an attractant." [WB:WBPerson2021] synonym: "acetone_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_variant [Term] id: WBPhenotype:0001466 name: AWA_odorant_chemotaxis_variant def: "Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWA sensory neuron in control animals. " [WB:WBPerson2021] synonym: "AWA_odorant_chemotaxis_abnormal" NARROW [] synonym: "AWA_volatile_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_variant [Term] id: WBPhenotype:0001467 name: AWC_odorant_chemotaxis_variant def: "Any variation in the directed movement of an animal in response to a volatile chemical stimulus that is usually received and processed by the AWC sensory neuron in control animals. " [WB:WBPerson2021] synonym: "AWC_odorant_chemotaxis_abnormal" NARROW [] synonym: "AWC_volatile_chemotaxis_abnormal" RELATED [] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_variant [Term] id: WBPhenotype:0001468 name: benzaldehyde_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of benzaldehyde. In C. elegans, at specific concentrations, benzaldehyde is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "benzaldehyde_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001467 ! AWC_odorant_chemotaxis_variant [Term] id: WBPhenotype:0001469 name: butanone_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of butanone. In C. elegans, at specific concentrations, butanone is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "butanone_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001467 ! AWC_odorant_chemotaxis_variant [Term] id: WBPhenotype:0001470 name: diacetyl_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of diacetyl. In C. elegans, at specific concentrations, diacetyl is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "diacetyl_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001466 ! AWA_odorant_chemotaxis_variant [Term] id: WBPhenotype:0001471 name: hexanol_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of hexanol. In C. elegans, at specific concentrations, hexanol is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "hexanol_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_variant [Term] id: WBPhenotype:0001472 name: isoamyl_alcohol_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of isoamyl alcohol. In C. elegans, at specific concentrations, isoamyl alcohol is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "isoamyl_alcohol_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001467 ! AWC_odorant_chemotaxis_variant [Term] id: WBPhenotype:0001473 name: pentanol_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanol. In C. elegans, at specific concentrations, pentanol is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "pentanol_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_variant [Term] id: WBPhenotype:0001474 name: pyrazine_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of pyrazine. In C. elegans, at specific concentrations, pyrazine is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "pyrazine_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001466 ! AWA_odorant_chemotaxis_variant [Term] id: WBPhenotype:0001475 name: trimethylthiazole_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of trimethylthiazole. In C. elegans, at specific concentrations, trimethylthiazole is an attractant." [WB:WBPerson2021, WB:WBPerson557] synonym: "trimethylthiazole_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_variant [Term] id: WBPhenotype:0001476 name: anterior_body_contraction_variant def: "Any variation in the defecation motor program that involves the contraction of the anterior body wall muscles compared to control." [WB:WBPaper00001937, WB:WBPerson2021, WB:WBPerson557] synonym: "anterior_body_contraction_abnormal" NARROW [] is_a: WBPhenotype:0000210 ! defecation_contraction_variant [Term] id: WBPhenotype:0001477 name: anterograde_transport_variant def: "Any variation in the directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons, compared to control." [GO:0008089, WB:WBPerson2021, WB:WBPerson557] synonym: "anterograde_transport_abnormal" NARROW [] is_a: WBPhenotype:0000854 ! intraflagellar_transport_defective [Term] id: WBPhenotype:0001478 name: body_elongation_variant def: "Any variation in the elongation of embryonic epidermal cells compared to control. In C. elegans, this elongation occurs along an anterior-posterior axis, which is required to transform the bean-shaped embryo into the elongated shape of the worm." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_elongation_abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0001479 name: dauer_pheromone_sensation_variant def: "Animals exhibit variations in any of a series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal that induces dauer formation in control animals." [GO:0043695, WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_pheromone_sensation_abnormal" NARROW [] is_a: WBPhenotype:0000305 ! pheromone_sensation_variant is_a: WBPhenotype:0001539 ! dauer_induction_variant [Term] id: WBPhenotype:0001480 name: grinder_relaxation_variant def: "Variations in the rhythmic relaxations of the a highly specialized cuticle region of the pharynx inside the lumen of the second bulb, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "grinder_relaxation_abnormal" NARROW [] relationship: part_of WBPhenotype:0000336 ! terminal_bulb_relaxation_variant [Term] id: WBPhenotype:0001481 name: thrashing_increased def: "The number of body thrashes within an aqueous environment in a given period of time is increased, compared with control worms." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001700 ! swimming_variant [Term] id: WBPhenotype:0001482 name: frequency_body_bend_reduced def: "Animals exhibit a reduction in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson557, WB:WBPerson712] synonym: "bending_frequency_reduced" RELATED [] is_a: WBPhenotype:0001213 ! locomotion_reduced is_a: WBPhenotype:0004023 ! frequency_of_body_bend_variant [Term] id: WBPhenotype:0001483 name: late_stage_egg_laid def: "The eggs being deposited by adults are of a later developmental stage, compared to control. In C. elegans, this is likely to be a consequence of delayed active egg-laying periods." [WB:WBPaper00004310, WB:WBPerson2021] is_a: WBPhenotype:0000545 ! egg_retention [Term] id: WBPhenotype:0001484 name: ammonium_acetate_chemotaxis_defective def: "Animals fail to execute directed movement in response to ammonium acetate. In C. elegans, ammonium acetate is an attractant. " [WB:WBPaper00004136] is_a: WBPhenotype:0000265 ! odorant_positive_chemotaxis_variant is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective [Term] id: WBPhenotype:0001485 name: ER_stress_response_variant def: "Animals exhibit variations in their response to the presence of unfolded proteins in the endoplasmic reticulum (ER) or to other ER-related stressors compared to control." [GO:0030968] synonym: "endoplasmic_reticulum_stress_response_abnormal" RELATED [] synonym: "ER_stress_response_abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell_stress_response_variant [Term] id: WBPhenotype:0001486 name: unfolded_protein_accumulation def: "Animals accumulate unfolded proteins in the endoplasmic reticulum (ER)." [WB:WBPerson557] is_a: WBPhenotype:0001485 ! ER_stress_response_variant [Term] id: WBPhenotype:0001487 name: male_spicule_development_variant def: "Animals exhibit variations in the development of the male elongated sclerotized structures covered by a hardened layer of cuticle in the tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) compared to control." [WB:cab, WB:WBPerson363] synonym: "male_spicule_development_abnormal" NARROW [] is_a: WBPhenotype:0000430 ! male_copulatory_structure_development_variant [Term] id: WBPhenotype:0001488 name: gubernaculum_development_variant def: "Animals exhibit variations in the development of the sclerotic cuticle that forms the roof of the proctodeum (gubernaculum) compared to control." [WB:cab, WB:WBPerson363] synonym: "gubernaculum_development_abnormal" NARROW [] relationship: part_of WBPhenotype:0001367 ! proctodeum_development_variant [Term] id: WBPhenotype:0001489 name: gubernaculum_morphology_variant def: "Animals exhibit variations in the structure or composition of the sclerotic cuticle that forms the roof of the proctodeum, from that observed in control animals." [WB:cab, WB:WBPaper00027278, WB:WBPerson363, WB:WBPerson712] synonym: "gubernaculum_morphology_abnormal" NARROW [] relationship: part_of WBPhenotype:0001359 ! proctodeum_morphology_variant [Term] id: WBPhenotype:0001492 name: no_back_end def: "Animals lack a properly developed posterior region compared to control. In C. elegans, mutants exhibit a severely deformed posterior region with a variable knob-like shape; accompanied by arrest at about the time of hatching with fairly normal pharyngeal and anterior development. Most mutants arrest as L1 larvae, and 5% do not hatch." [WB:cab, WB:cgc4499] synonym: "Nob" BROAD three_letter_name [] is_a: WBPhenotype:0000081 ! L1_arrest is_a: WBPhenotype:0000793 ! posterior_body_morphology_variant is_a: WBPhenotype:0000800 ! posterior_region_development_variant is_a: WBPhenotype:0000867 ! embryonic_arrest [Term] id: WBPhenotype:0001493 name: VPC_cell_division_precocious def: "VPCs (vulval precursor cells) divide at an earlier stage of development compared to control animals; in C. elegans, VPCs divide in the mid-L3 stage to generate the 22 cells that comprise the vulva." [pmid:16300753, WB:cab] is_a: WBPhenotype:0000345 ! VPC_cell_division_variant [Term] id: WBPhenotype:0001494 name: distal_tip_cell_migration_precocious def: "DTCs migrate at an earlier stage of development, compared to control." [pmid:16300753, WB:cab] is_a: WBPhenotype:0000195 ! distal_tip_cell_migration_variant [Term] id: WBPhenotype:0001495 name: cell_division_precocious def: "Cells divide at an earlier stage of development compared to control animals." [WB:cab] is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0001496 name: metaphase_to_anaphase_transition_defect def: "Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle." [GO:0007091, WB:WBPerson712] is_a: WBPhenotype:0000740 ! cell_cycle_variant [Term] id: WBPhenotype:0001497 name: mitotic_metaphase_to_anaphase_transition_defect def: "Cells exhibit variations in the process whereby a cell progresses from metaphase to anaphase during mitosis, compared to control. Metaphase is the second stage of chromosome segregation in the cell cycle where chromosomes become aligned on the equatorial plate of the cell and anaphase is the stage where sister chromatids separate and migrate towards the poles of the spindle." [GO:0007091, WB:WBPerson712] is_a: WBPhenotype:0001496 ! metaphase_to_anaphase_transition_defect [Term] id: WBPhenotype:0001498 name: sperm_pseudopod_physiology_variant def: "Animals exhibit variations in any physical or chemical process required for the pseudopod of the sperm to carry out its normal functions or activities or be able to perceive and respond to stimuli, compared to control animals." [WB:WBPerson557] synonym: "sperm_pseudopod_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000987 ! germ_cell_physiology_variant [Term] id: WBPhenotype:0001499 name: meiotic_chromosome_segregation_variant def: "Variations in the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle, compared to control. " [GO:0045132, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "meiotic_chromosome_segregation_abnormal" NARROW [] is_a: WBPhenotype:0000773 ! chromosome_segregation_variant [Term] id: WBPhenotype:0001500 name: pentanedione_chemotaxis_variant def: "Any variation in the directed movement of a worm in response to a specific concentration gradient of pentanedione." [WB:cab, WB:cgc2931] synonym: "pentanedione_chemotaxis_abnormal" NARROW [] is_a: WBPhenotype:0001467 ! AWC_odorant_chemotaxis_variant [Term] id: WBPhenotype:0001501 name: odorant_discrimination_defective def: "Animals fail to discriminate between distinct odorants." [WB:cab] synonym: "odorant_discrimination_abnormal" NARROW [] is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_variant [Term] id: WBPhenotype:0001502 name: chemical_resistant def: "Animals fail to respond to the concentration of a specific chemical that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000523 ! chemical_response_variant [Term] id: WBPhenotype:0001503 name: ventral_nerve_cord_maintenance_variant def: "Any variation in the mechanisms used to ensure that axons in the ventral nerve cord maintain their correct positioning after termination of axonal outgrowth and target recognition compared to control." [WB:WBPaper00005064, WB:WBPerson557] synonym: "ventral_nerve_cord_maintenance_abnormal" NARROW [] is_a: WBPhenotype:0000515 ! ventral_nerve_cord_development_variant [Term] id: WBPhenotype:0001504 name: maternal_effect_sterile def: "Sterility caused by aberrant maternal components required for normal postembryonic development and/or function of the germ line." [WB:WBPaper00001477] synonym: "Mes" BROAD three_letter_name [] is_a: WBPhenotype:0001037 ! sterile_progeny [Term] id: WBPhenotype:0001505 name: spontaneous_reversal_variant def: "Any variation in the processes that govern spontaneous backward locomotion compared to control." [WB:WBPaper00001311, WB:WBPerson557] synonym: "spontaneous_reversal_abnormal" NARROW [] is_a: WBPhenotype:0001702 ! directionality_variant [Term] id: WBPhenotype:0001506 name: spontaneous_reversal_rate_variant def: "Any variation in the processes that govern the rate at which spontaneous backward locomotion is initiated compared to control. In C. elegans, animals moving forward consistently initiate backward locomotion approximately 10 times per 3 minutes." [WB:WBPaper00001311, WB:WBPaper00026650, WB:WBPerson557] synonym: "spontaneous_reversal_rate_abnormal" NARROW [] is_a: WBPhenotype:0001505 ! spontaneous_reversal_variant [Term] id: WBPhenotype:0001507 name: Bacillus_thuringiensis_toxin_resistant def: "Animals fail to be affected by toxins produced by Bacillus thuringiensis (Bt toxins) in the same manner as control animals." [GO:0042493, WB:WBPaper00004264, WB:WBPaper00004776, WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001508 name: anchor_cell_fusion_defective def: "Any perturbation that disrupts the fusion between the anchor cell and the surrounding utse syncytium. Such variations result in the loss of uterine-vulval connectivity and continuity." [WB:WBPaper00029363, WB:WBPerson2021] synonym: "anchor_cell_fusion_abnormal" NARROW [] is_a: WBPhenotype:0000165 ! cell_fusion_variant is_a: WBPhenotype:0000283 ! vulva_uterus_connection_defective [Term] id: WBPhenotype:0001509 name: rays_missing alt_id: WBPhenotype:0000407 def: "Any of the finger-like sensory sensilla that project from the tail and embed in the male fan are absent." [WB:WBPerson2021, WB:WBPerson557] synonym: "ray_loss" EXACT [] is_a: WBPhenotype:0000199 ! male_tail_sensory_ray_development_variant is_a: WBPhenotype:0000505 ! male_ray_morphology_variant [Term] id: WBPhenotype:0001510 name: neuronal_cell_fate_specification_variant def: "Any variation in the processes that govern acquisition of neuronal cell fates compared to control." [WB:WBPerson2021] synonym: "neuronal_cell_fate_specification_abnormal" NARROW [] is_a: WBPhenotype:0000216 ! cell_fate_specification_variant [Term] id: WBPhenotype:0001511 name: linker_cell_migration_variant def: "Variations in the stereotypical migration pattern of the linker cell in a developing male compared to control." [WB:WBPaper00028966, WB:WBPerson2021] synonym: "linker_cell_migration_abnormal" NARROW [] is_a: WBPhenotype:0000594 ! cell_migration_variant [Term] id: WBPhenotype:0001512 name: loss_of_left_right_neuronal_asymmetry def: "Bilaterally symmetric neurons fail to acquire specific left-right asymmetric properties such as L/R specific cell position, cell death or gene expression." [WB:WBPerson2021] is_a: WBPhenotype:0001510 ! neuronal_cell_fate_specification_variant [Term] id: WBPhenotype:0001513 name: dense_core_vesicle_exocytosis_variant def: "Variations in the process of secretion of a class of membrane-bound vesicles found inside neurons, gland cells, and some epithelial cells in which the central core appears darkly stained when viewed in thin section by electron microscopy, compared to control. Exocytosis occurs via the fusion of the vesicle with the plasma membrane of a cell (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dense_core_vesicle_exocytosis_abnormal" NARROW [] is_a: WBPhenotype:0000728 ! exocytosis_variant [Term] id: WBPhenotype:0001514 name: synaptic_vesicle_endocytosis_variant def: "Variations in the uptake of a small membrane-bound organelle, filled with neurotransmitter(s) and/or neuropeptides, by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle compared to control(Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "synaptic_vesicle_endocytosis_abnormal" NARROW [] is_a: WBPhenotype:0001422 ! endocytic_transport_defect is_a: WBPhenotype:0001684 ! synaptic_vesicle_homeostasis_variant [Term] id: WBPhenotype:0001515 name: struts_variant def: "Animals exhibit variations in the quantity or patterning of electron-dense columnar structures that join the basal and cortical cuticle layers, from that observed in control animals." [WB:WBPaper00000465, WB:WBPerson712] synonym: "struts_abnormal" NARROW [] is_a: WBPhenotype:0000948 ! cuticle_morphology_variant [Term] id: WBPhenotype:0001516 name: helical_cuticle def: "Animals exhibit a helically twisted cuticle. In practice the degree of twisting is measured as the number of helical twists the alae make about anterior/posterior axis of the animal." [WB:WBPaper00000465, WB:WBPerson712] synonym: "cuticle_helicity_abnormal" NARROW [] is_a: WBPhenotype:0000948 ! cuticle_morphology_variant [Term] id: WBPhenotype:0001517 name: annulae_morphology_variant def: "Animals exhibit variations in the circumferential pattern of ridges in the outer cortical layer of the cuticle, compared to that observed in control animals of the same developmental stage." [WB:WBPaper00000465, WB:WBPaper00031415, WB:WBPerson712] synonym: "annulae_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000948 ! cuticle_morphology_variant [Term] id: WBPhenotype:0001518 name: biogenic_amine_physiology_variant def: "Any variation in the levels and/or localization of biogenic amines compared to control animals." [WB:WBPaper00000365] synonym: "biogenic_amine_physiology_abnormal" NARROW [] synonym: "FIF" BROAD three_letter_name [] synonym: "Formaldehyde_induced_fluorescence_abnormal " RELATED [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0001519 name: posterior_cell_migration_variant def: "Any variation in the orderly movement of cells along the posterior axis of the animal (abolished, misdirected or incomplete) compared to control." [WB:WBPerson2021] synonym: "abnormal_posterior_cell_migration" NARROW [] is_a: WBPhenotype:0000594 ! cell_migration_variant [Term] id: WBPhenotype:0001520 name: posterior_neuron_migration_variant def: "Any variation in the orderly movement of neurons along the posterior axis of the animal(abolished, misdirected or incomplete) compared to control." [WB:WBPerson2021] synonym: "abnormal_posterior_neuron_migration" NARROW [] is_a: WBPhenotype:0001140 ! neuron_migration_variant [Term] id: WBPhenotype:0001521 name: body_elongation_retracted def: "Embryos retract after the embryonic elongation process." [WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0001522 name: spicules_protrude def: "The elongated sclerotized structures covered by a hardened layer of cuticle in the male tail (which are actively everted during copulation to fasten the male copulatory fan to the vulva) constitutively extend into the external environment through the cloacal opening. In C. elegans males there are two copulatory spicules." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000908 ! cloacal_morphology_variant [Term] id: WBPhenotype:0001523 name: extracellular_matrix_variant def: "Any variation in the makeup, density or area of the ECM compared to control." [WB:WBPerson712] synonym: "extracellular_matrix_abnormal" NARROW [] is_a: WBPhenotype:0000912 ! pericellular_component_morphology_variant [Term] id: WBPhenotype:0001524 name: quiescence_variant def: "Exhibition of quiescent behavior under inappropriate conditions and improper recovery from quiescent state. Quiescent behavior is normally coupled with lethargus." [WB:WBPerson2021] synonym: "quiescence_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0001525 name: terminal_bulb_morphology_variant def: "Animals exhibit variations in the structure or organization of the posterior region of the pharynx compared to control." [WB:WBPerson2021] synonym: "terminal_bulb_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000709 ! pharyngeal_morphology_variant [Term] id: WBPhenotype:0001526 name: ciliated_neuron_morphology_variant def: "Animals exhibit variations in the structure or organization of any one of the specialized sensory receptor cells of the nervous system that compared to control animals. In C. elegans, these specialized cells are characterized as having axoneme containing dendritic projections emanating from their cell body." [WB:WBPaper00000503, WB:WBPaper00029016, WB:WBPerson712] comment: WBbt:0006816 synonym: "ciliated_neuron_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum_morphology_variant [Term] id: WBPhenotype:0001527 name: amphid_phasmid_sensillum_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head or along the tail, compared to that observed in control animals." [WB:WBPerson712] comment: WBbt:0005391 synonym: "amphid_phasmid_sensillum_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum_morphology_variant [Term] id: WBPhenotype:0001528 name: sensillum_accessory_cell_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of any component of the sensillum channel including the sheath and or socket cells, their junctions with each other, channel neurons or surrounding epithelia compared to control." [WB:WBPaper00000932, WB:WBPerson712] synonym: "sensillum_accessory_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum_morphology_variant [Term] id: WBPhenotype:0001529 name: sensilium_sheath_cell_variant def: "Any variation in the form, structure or composition of an interfacial epithelial cell which forms a specialized environment surrounding the ciliated sensory ending(s) of one or more neurons and is often accompanied by a more distal socket cell compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "sensilium_sheath_cell_abnormal" NARROW [] is_a: WBPhenotype:0001528 ! sensillum_accessory_cell_morphology_variant [Term] id: WBPhenotype:0001530 name: cephalic_sensillum_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake." [WB:WBPaper00000214, WB:WBPaper00000503, WB:WBPaper00000932, WB:WBPerson712] comment: WBbt:0006920 synonym: "cephalic_sensillum_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum_morphology_variant [Term] id: WBPhenotype:0001531 name: labial_sensillum_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth." [WB:WBPaper00000214, WB:WBPaper00000938, WB:WBPerson712] synonym: "labial_sensillum_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum_morphology_variant [Term] id: WBPhenotype:0001532 name: inner_labial_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2." [WB:WBPaper00000938, WB:WBPerson712] synonym: "inner_labial_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001531 ! labial_sensillum_morphology_variant [Term] id: WBPhenotype:0001533 name: outer_labial_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum." [WB:WBPaper00000938, WB:WBPerson712] synonym: "outer_labial_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001531 ! labial_sensillum_morphology_variant [Term] id: WBPhenotype:0001534 name: neuronal_ECM_variant def: "Any variation in makeup, density or area of the ECM lending structure to neurons compared to control animals. In C. elegans, the neuronal ECM is sometimes referred to as a mantle." [WB:WBPaper00000502, WB:WBPerson712] synonym: "neuronal_ECM_abnormal" NARROW [] is_a: WBPhenotype:0001523 ! extracellular_matrix_variant [Term] id: WBPhenotype:0001535 name: deirid_sensillum_morphology_variant def: "Animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC." [WB:WBPaper00000938, WB:WBPaper00029016, WB:WBPerson712] synonym: "deirid_sensillum_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000299 ! sensillum_morphology_variant [Term] id: WBPhenotype:0001536 name: embryonic_cell_patterning_variant def: "Embryos exhibit variations in the patterning of differentiated cell types, compared to control." [WB:WBPerson557] synonym: "embryonic_cell_patterning_abnormal" NARROW [] is_a: WBPhenotype:0000050 ! embryonic_lethal [Term] id: WBPhenotype:0001537 name: mRNA_turnover_variant def: "Any variation in the ability of cells to monitor the quality of their mRNAs and degrade any transcripts that are poorly or incompletely translated compared to control." [WB:WBPaper00004926] synonym: "mRNA_turnover_abnormal" NARROW [] is_a: WBPhenotype:0000028 ! RNA_processing_variant [Term] id: WBPhenotype:0001538 name: mRNA_surveillance_defective def: "Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia." [WB:WBPaper00001192, WB:WBPaper00004926] synonym: "Smg" NARROW [] is_a: WBPhenotype:0000028 ! RNA_processing_variant [Term] id: WBPhenotype:0001539 name: dauer_induction_variant def: "Animals exhibit variations in the entry into the dauer stage when exposed to conditions that induce dauer formation in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_induction_abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer_arrest_variant [Term] id: WBPhenotype:0001540 name: dauer_lifespan_variant def: "The life span of dauer-staged animals is either longer or shorter than that observed in control dauer animals." [WB:WBPerson2021] synonym: "dauer_lifespan_abnormal" NARROW [] is_a: WBPhenotype:0001547 ! dauer_metabolism_variant [Term] id: WBPhenotype:0001541 name: dauer_gonad_arrest_variant def: "Variations in the execution of the developmentally-regulated cell cycle arrest in the gonad during the dauer stage, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_gonad_arrest_abnormal" NARROW [] is_a: WBPhenotype:0000637 ! dauer_formation_variant [Term] id: WBPhenotype:0001542 name: dauer_feeding_suppressed_variant def: "Any variation in the inhibition of feeding which is induced/occurs during the dauer stage compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_feeding_suppressed_abnormal" NARROW [] is_a: WBPhenotype:0001001 ! dauer_behavior_variant [Term] id: WBPhenotype:0001543 name: dauer_reduced_locomotion_variant def: "Dauer stage animals exhibit a decrease in self-propelled movement on a solid medium compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_reduced_locomotion_abnormal" NARROW [] is_a: WBPhenotype:0001001 ! dauer_behavior_variant [Term] id: WBPhenotype:0001544 name: dauer_sensory_response_variant def: "Variations in the state or activity of a dauer stage organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_sensory_response_abnormal" NARROW [] is_a: WBPhenotype:0001001 ! dauer_behavior_variant [Term] id: WBPhenotype:0001545 name: dauer_body_morphology_variant def: "Any variation in the overall structure or appearance of an animal progressing through an alternative larval stage in response to environmental stresses compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_body_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000934 ! developmental_morphology_variant [Term] id: WBPhenotype:0001546 name: dauer_resistance_to_harsh_conditions_variant def: "Variations which lead to the decreased ability of dauer larva to survive at extreme conditions, such as high or low temperatures, the presence of dilute acids, detergents, anesthetics, or even fixatives, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_resistance_to_harsh_conditions_abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer_arrest_variant [Term] id: WBPhenotype:0001547 name: dauer_metabolism_variant def: "Animals exhibit variations in the chemical reactions and pathways that occur during the dauer life stage, compared to control." [WB:WBPerson2021] synonym: "dauer_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000159 ! dauer_arrest_variant [Term] id: WBPhenotype:0001548 name: dauer_axial_ratio_variant def: "Any variation in the ratio of the body length to body width in a dauer stage animal, compared to control. Long thin animals will have a high axial ratio." [WB:WBPerson557] synonym: "dauer_axial_ratio_abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer_body_morphology_variant [Term] id: WBPhenotype:0001549 name: dauer_gut_variant def: "Dauer stage animals exhibit variations in the form, structure or composition of the chain of cuboidal cells which form a central lumen lined by microvilli that allow the passage of food, compared to control. Food passes from the posterior pharynx to the intestine where it is digested and then on to the rectum which processes the waste products for excretion." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_gut_abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer_body_morphology_variant [Term] id: WBPhenotype:0001550 name: dauer_buccal_cavity_morphology_variant def: "Variations in the form or composition of the cuticle-lined lumenal region which lies just behind the lips at the entrance to the pharyngeal lumen in dauer stage animals compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_buccal_cavity_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer_body_morphology_variant [Term] id: WBPhenotype:0001551 name: dauer_cuticle_variant def: "Any variation in the progression of the formation of the rigid external coating (which is secreted by the hypodermis, seam and some interfacial epithelial cells) during the dauer larva stage, compared to control animals (Wormatlas). The dauer larval stage is a developmentally arrested larval stage that is specialized for survival under harsh, or otherwise unfavorable environmental conditions. " [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_cuticle_abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer_body_morphology_variant [Term] id: WBPhenotype:0001552 name: dauer_pharynx_morphology_variant def: "Variations in the form or composition of the mouthparts at the anterior end of the digestive tract during the dauer stage, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_pharynx_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer_body_morphology_variant [Term] id: WBPhenotype:0001553 name: dauer_excretory_gland_variant def: "Dauer stage animals exhibit variations in the form, structure or composition of a pair of large cells in the head that fuse to form a single gland whose contents are released into the excretory duct through a specialized secretory membrane, compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_excretory_gland_abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer_body_morphology_variant [Term] id: WBPhenotype:0001554 name: dauer_nose_morphology_variant def: "Dauer stage animals exhibit variations in the form, structure or composition of any portion of the extreme anterior part of their body compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_nose_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer_body_morphology_variant [Term] id: WBPhenotype:0001555 name: dauer_sensory_system_morphology_variant def: "Any variations in the form, structure or composition of a set of interacting or interdependent entities forming the dauer sensory system, compared to control. The dauer sensory system is used to perceive the physical and chemical environment during the dauer larval stage." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_sensory_system_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001545 ! dauer_body_morphology_variant [Term] id: WBPhenotype:0001556 name: dauer_sensillum_variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sense organs comprised of ciliated sensory nerve endings enveloped by sheath and/or socket cells, from that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_sensillum_abnormal" NARROW [] is_a: WBPhenotype:0001555 ! dauer_sensory_system_morphology_variant [Term] id: WBPhenotype:0001557 name: dauer_labial_sensillum_variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the sensilla of the mouth compared to control. In C. elegans, these sensillum are arranged in two (inner and outer) concentric rings around the mouth." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_labial_sensillum_abnormal" NARROW [] is_a: WBPhenotype:0001556 ! dauer_sensillum_variant [Term] id: WBPhenotype:0001558 name: dauer_amphid_sensillum_variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of any component of any specialized chemosensory organs located on the head, compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_amphid_sensillum_abnormal" NARROW [] is_a: WBPhenotype:0001556 ! dauer_sensillum_variant [Term] id: WBPhenotype:0001559 name: dauer_deirid_sensillum_variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the sensilla situated laterally in the anterior (ADE) or the posterior (PDE) of the animal compared to control. In C. elegans, each of the 4 deirid sensilla (2ADE, 2 PDE) contains a pair of neurons with ciliated dendritic processes that lie in a channel formed by a socket cell and invaginated sheath cell. The cilia of the deirids terminate in the subcuticle and are not exposed to the outside; however occasionally take up FITC." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_deirid_sensillum_abnormal" NARROW [] is_a: WBPhenotype:0001556 ! dauer_sensillum_variant [Term] id: WBPhenotype:0001560 name: dauer_sensory_system_plug_variant synonym: "dauer_sensory_system_plug_abnormal" NARROW [] is_obsolete: true [Term] id: WBPhenotype:0001561 name: dauer_inner_labial_sensillum_variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the inner labial ring compared to control. In C. elegans, the ring is composed of six sensilla, which include associated neurons IL1 & IL2." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_inner_labial_sensillum_abnormal" NARROW [] is_a: WBPhenotype:0001557 ! dauer_labial_sensillum_variant [Term] id: WBPhenotype:0001562 name: dauer_outer_labial_sensillum_variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of the components of the outer labial ring compared to control. In C. elegans, this ring consists of four sensilla (OLQ) or the two additional lateral sensilla (OLL), which are part of the labial sensillum." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_outer_labial_sensillum_abnormal" NARROW [] is_a: WBPhenotype:0001557 ! dauer_labial_sensillum_variant [Term] id: WBPhenotype:0001563 name: dauer_cephalic_sensillum_variant def: "Dauer stage animals exhibit variations in the quantity, structure or organization of any component of a specialized sensory organ in the head that contains a CEP receptor neuron, compared to control. In C. elegans, cells in these organs are refractory to FITC dye uptake." [WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_cephalic_sensillum_abnormal" NARROW [] is_a: WBPhenotype:0001556 ! dauer_sensillum_variant [Term] id: WBPhenotype:0001564 name: duration_of_self_fertility_variant def: "The window of production of self-fertilized eggs exceeds or does not extend to the same length as control." [WB:WBPaper00002419, WB:WBPerson712] synonym: "duration_of_self_fertility_abnormal" NARROW [] is_a: WBPhenotype:0000806 ! hermaphrodite_fertility_variant [Term] id: WBPhenotype:0001565 name: lysine_chemotaxis_defective def: "Failure to execute characteristic response to lysine as defined by control animals. In C. elegans, lysine is an attractant." [WB:WBPaper00001481, WB:WBPaper00001786, WB:WBPerson2021] is_a: WBPhenotype:0001441 ! aqueous_positive_chemotaxis_defective [Term] id: WBPhenotype:0001566 name: ventral_enclosure_variant def: "Any variation in the process that regulates the migration of ventral epidermal cells toward the ventral midline (to encase underlying cells in an epithelial monolayer) in developing embryos compared to control." [WB:WBPaper00027244, WB:WBPerson2021] synonym: "ventral_enclosure_abnormal" NARROW [] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0001567 name: nuclei_enlarged def: "Nuclei of specific cells are larger compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001028 ! nuclear_appearance_variant [Term] id: WBPhenotype:0001568 name: mRNA_export_variant def: "Any variation in the export of mRNA from the cell nucleus compared to control." [WB:WBPaper00005960] synonym: "mRNA_export_abnormal" NARROW [] is_a: WBPhenotype:0000114 ! mRNA_expression_variant is_a: WBPhenotype:0001706 ! nuclear_export_defective [Term] id: WBPhenotype:0001569 name: body_wall_muscle_myosin_organization_defective def: "The characteristic organization of myosin filaments into discrete A-bands within the muscle cells is disrupted. In C. elegans, myosin filaments no longer appear as continuous longitudinally oriented fibers across the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021] synonym: "body wall muscle thick myofilament organization abnormal" RELATED [WB:WBPerson2021] synonym: "body_wall_muscle_myosin_organization_abnormal" NARROW [] is_a: WBPhenotype:0000926 ! body_wall_muscle_morphology_variant [Term] id: WBPhenotype:0001570 name: body_wall_muscle_actin_organization_defective def: "The characteristic organization of actin filaments into I-bands is disrupted. In C. elegans, actin filaments no longer appear as thin continuous longitudinal stripes along the muscle quadrants." [WB:WBPaper00001894, WB:WBPerson2021] synonym: "body wall muscle thin myofilament organization abnormal" RELATED [WB:WBPerson2021] synonym: "body_wall_muscle_actin_organization_abnormal" NARROW [] is_a: WBPhenotype:0000926 ! body_wall_muscle_morphology_variant [Term] id: WBPhenotype:0001571 name: body_wall_muscle_cell_polarization_variant def: "Variations in the accumulation of muscle proteins at membranes where adjacent muscle cells contact each other and the hypodermis compared to control. In C. elegans, during early embryonic body wall muscle development, muscle, basement membrane, and hypodermal components are all colocalized in a continuous linear structure at the site of muscle-hypodermal contact." [WB:WBPaper00001895] synonym: "body_wall_muscle_cell_polarization_abnormal" NARROW [] is_a: WBPhenotype:0000926 ! body_wall_muscle_morphology_variant [Term] id: WBPhenotype:0001572 name: masculinized def: "Animals that are not ordinarily male, exhibit male-specific attributes. In C. elegans, XX animals exhibit male-specific attributes" [WB:WBPaper00000178, WB:WBPaper00001206, WB:WBPerson712] is_a: WBPhenotype:0001022 ! hermaphrodite_sexual_development_variant [Term] id: WBPhenotype:0001573 name: nicotine_response_variant def: "Animals exhibit variations in the response to the addition of nicotine compared to that observed in control animals. Nicotine is a cholinergic agonist." [WB:WBPerson557] synonym: "nicotine_response_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001574 name: ATP_levels_variant def: "Animals exhibit variations in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology." [WB:WBPerson2021, WB:WBPerson557] synonym: "ATP_levels_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0001575 name: ATP_levels_reduced def: "Animals exhibit a decrease in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001574 ! ATP_levels_variant [Term] id: WBPhenotype:0001576 name: mitochondria_spacing_variant def: "Variations in the spatial distribution of the mitochondria within the cell compared to control." [GO:0048311, WB:WBPerson2021, WB:WBPerson557] synonym: "mitochondria_spacing_abnormal" NARROW [] is_a: WBPhenotype:0001401 ! mitochondria_morphology_variant [Term] id: WBPhenotype:0001577 name: mitochondria_alignment_variant def: "Animals exhibit variations in the parallel arrangement of mitochondria within a cell compared to control. " [WB:WBPaper00028954] synonym: "mitochondria_alignment_abnormal" NARROW [] is_a: WBPhenotype:0001401 ! mitochondria_morphology_variant [Term] id: WBPhenotype:0001578 name: cholinergic_agonist_resistant def: "Animals fail to respond to the concentration of cholinergic agonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001579 name: cholinergic_agonist_hypersensitive def: "Animals respond to a cholinergic agonist at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive [Term] id: WBPhenotype:0001580 name: nuclear_envelope_breakdown_variant def: "Any variation in the progression of the controlled breakdown of the nuclear envelope, compared to control." [GO:0051081, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "nuclear_envelope_breakdown_abnormal" NARROW [] is_a: WBPhenotype:0001138 ! nucleus_defective_early_emb [Term] id: WBPhenotype:0001581 name: X_linked_gene_expression_enhanced def: "Levels of transcripts associated with genes on the X chromosome are increased compared to control." [WB:WBPaper00001011, WB:WBPerson712] is_a: WBPhenotype:0000718 ! dosage_compensation_variant [Term] id: WBPhenotype:0001582 name: X_linked_gene_expression_reduced def: "Levels of transcripts associated with genes on the X chromosome are decreased compared to control." [WB:WBPaper00001011, WB:WBPerson712] is_a: WBPhenotype:0000718 ! dosage_compensation_variant [Term] id: WBPhenotype:0001583 name: XXX_progeny def: "Animals segregate progeny with 3 X chromosomes." [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001584 name: chromosome_alignment_variant def: "Any variation in the movement of chromosomes to the spindle equator during mitosis compared to control animals." [GO:0051310, WB:WBPerson557] synonym: "chromosome_alignment_at_metaphase_plate_abnormal" NARROW [] synonym: "chromosome_alignment_at_metaphase_plate_variant" NARROW [] synonym: "chromosome_congression" RELATED [] is_a: WBPhenotype:0000773 ! chromosome_segregation_variant [Term] id: WBPhenotype:0001585 name: asymmetric_cell_division_variant def: "Any variation in a cell's ability to divide asymmetrically to produce two daughter cells with different developmental potentials compared to control. " [GO:0008356, WB:WBPerson2021, WB:WBPerson557] synonym: "asymmetric_cell_division_abnormal" NARROW [] is_a: WBPhenotype:0001235 ! cell_division_polarity_variant [Term] id: WBPhenotype:0001586 name: multiple_anchor_cells def: "Animals contain more than one anchor cell. In C. elegans, presumptive ventral uterine cells undergo fate transformation and instead acquire the properties of an anchor cell (often due to defects in lateral signaling)." [WB:WBPaper00001423, WB:WBPerson2021] synonym: "double anchor cell" NARROW [] is_a: WBPhenotype:0000399 ! somatic_gonad_development_variant [Term] id: WBPhenotype:0001587 name: actin_organization_biogenesis_variant def: "Animals exhibit variations in the formation and/or arrangement of actin, an abundant cytoskeletal protein in most cells, often linked to the plasma membrane and concentrated at cell junctions compared to control (Wormatlas)." [GO:0030036, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "actin_organization_biogenesis_abnormal" NARROW [] is_a: WBPhenotype:0001345 ! cytoskeleton_organization_biogenesis_variant [Term] id: WBPhenotype:0001588 name: microtubule_organization_biogenesis_variant def: "Animals exhibit variations in the form, structure, composition or arrangement of \na robust macromolecular array, composed primarily of tubulin, which forms long extended cytoskeletal elements compared to control (Wormatlas)." [GO:0000226, WB:WBPerson2021, WB:WBPerson557] comment: possible XP synonym: "microtubule_organization_biogenesis_abnormal" NARROW [] is_a: WBPhenotype:0001345 ! cytoskeleton_organization_biogenesis_variant [Term] id: WBPhenotype:0001589 name: microtubule_nucleation_variant def: "Any variation that alters the characteristic de novo formation of a microtubule compared to control." [GO:0007020] synonym: "microtubule_nucleation_abnormal" NARROW [] is_a: WBPhenotype:0001588 ! microtubule_organization_biogenesis_variant [Term] id: WBPhenotype:0001590 name: microtubule_depolymerization_variant def: "Any variation that alters the characteristic removal of tubulin heterodimers from one or both ends of a microtubule compared to control." [GO:0007019] synonym: "microtubule_depolymerization_abnormal" NARROW [] is_a: WBPhenotype:0001588 ! microtubule_organization_biogenesis_variant [Term] id: WBPhenotype:0001591 name: microtubule_polymerization_variant def: "Any variation that alters the characteristic addition of tubulin heterodimers to one or both ends of a microtubule compared to control." [GO:0046785] synonym: "microtubule_polymerization_abnormal" NARROW [] is_a: WBPhenotype:0001588 ! microtubule_organization_biogenesis_variant [Term] id: WBPhenotype:0001592 name: fainter def: "Alternating periods of stopping and moving; Motion is interrupted by periods of inactivity lasting several seconds." [WB:WBPaper00031286] is_a: WBPhenotype:0001213 ! locomotion_reduced [Term] id: WBPhenotype:0001593 name: transgene_silencing_variant def: "Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, compared to control. In C. elegans this silencing occurs only in the germline." [WB:WBPaper00005399, WB:WBPerson2021, WB:WBPerson557] synonym: "transgene_silencing_abnormal" NARROW [] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001594 name: germline_transgene_silencing_variant def: "Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the germline, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "germline_transgene_silencing_abnormal" NARROW [] is_a: WBPhenotype:0001593 ! transgene_silencing_variant [Term] id: WBPhenotype:0001595 name: somatic_transgene_silencing_variant def: "Animals exhibit variations in the homology-dependent transcriptional level silencing of the expression of exogenous DNA that has been introduced into the organism, in the soma, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "somatic_transgene_silencing_abnormal" NARROW [] is_a: WBPhenotype:0001593 ! transgene_silencing_variant [Term] id: WBPhenotype:0001596 name: tail_bobbed def: "Swelling of the tail hypodermis resulting in a prematurely-truncated and thickened appearance of the tail. In C. elegans, this is usually applies to hermaphrodites" [WB:WBPaper00024194, WB:WBPerson712] is_a: WBPhenotype:0000073 ! tail_morphology_variant [Term] id: WBPhenotype:0001597 name: muscle_missing def: "Any variation that results in a fewer than control number of muscle cells." [WB:WBPaper00001423, WB:WBPaper00002946, WB:WBPerson2021] is_a: WBPhenotype:0000622 ! muscle_system_development_variant [Term] id: WBPhenotype:0001598 name: inhibitor_of_serotonin_uptake_variant def: "Treatment with inhibitors of serotonin reuptake does not elicit the same response as observed for control animals." [WB:WBPerson712] synonym: "inhibitor_of_serotonin_uptake_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001599 name: ouabain_resistant def: "Animals fail to respond to the concentration of ouabain that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, resistance to ouabain is often assayed via body contraction response." [WB:WBPaper00000484, WB:WBPerson2021] is_a: WBPhenotype:0000331 ! inhibitors_of_na_k_atpase_resistant [Term] id: WBPhenotype:0001600 name: contraction_response_to_ouabain_resistant def: "Animals require increased concentration or longer exposure to ouabain to elicit the rapid muscular contractions seen in control animals." [WB:WBPaper00000484] is_a: WBPhenotype:0001599 ! ouabain_resistant [Term] id: WBPhenotype:0001601 name: biogenic_amine_receptor_antagonist_resistant def: "Animals fail to respond to the concentration of biogenic amine receptor antagonist that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson712] synonym: "serotonin_receptor_antagonist" NARROW [] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001602 name: methiothepin_resistant def: "Animals fail to respond to the concentration of methiothepin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00031241, WB:WBPerson721] is_a: WBPhenotype:0001601 ! biogenic_amine_receptor_antagonist_resistant [Term] id: WBPhenotype:0001603 name: cyproheptadine_resistant def: "Animals fail to respond to the concentration of cyproheptadine that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00031241, WB:WBPerson721] is_a: WBPhenotype:0001601 ! biogenic_amine_receptor_antagonist_resistant [Term] id: WBPhenotype:0001604 name: mianserin_resistant def: "Animals fail to respond to the concentration of mianserin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00031241, WB:WBPerson721] synonym: "dibenzazepine_resistant" RELATED [] is_a: WBPhenotype:0001601 ! biogenic_amine_receptor_antagonist_resistant [Term] id: WBPhenotype:0001605 name: extended_life_span_response_to_mianserin_resistant def: "Animals do not live longer in response to mianserin compared to control." [WB:WBPaper00031241, WB:WBPerson721] is_a: WBPhenotype:0001604 ! mianserin_resistant [Term] id: WBPhenotype:0001606 name: ethanol_hypersensitive def: "Animals respond to ethanol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00002358, WB:WBPerson712] synonym: "alcohol_sensistive" BROAD [] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001607 name: paralysis_response_to_ethanol_hypersensitive def: "Animals become paralyzed in response to ethanol at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00002358, WB:WBPerson712] is_a: WBPhenotype:0001606 ! ethanol_hypersensitive [Term] id: WBPhenotype:0001608 name: enflurane_hypersensitive def: "Animals respond to the anesthetic enflurane at lower concentrations or shorter exposure times than control animals." [WB:WBPaper00002037, WB:WBPerson721] synonym: "ether_hypersensitive" RELATED [] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001609 name: isoflurane_hypersensitive def: "Animals respond to the anesthetic isoflurane at lower concentrations or shorter response times than control animals." [WB:WBPaper00002037, WB:WBPerson721] synonym: "ether_hypersensitive" RELATED [] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001610 name: diethyl_ether_hypersensitive def: "Animals respond to the anesthetic ether at lower concentrations or shorter response times than control animals." [WB:WBPaper00001063, WB:WBPaper00002037, WB:WBPerson721] synonym: "ether_hypersensitive" RELATED [] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001611 name: halothane_hypersensitive def: "Animals respond to the lipid-soluble anesthetic halothane at lower concentrations or shorter response times compared to control animals." [WB:WBPaper00000958, WB:WBPaper00031286, WB:WBPerson721] is_a: WBPhenotype:0000008 ! anesthetic_hypersensitive [Term] id: WBPhenotype:0001612 name: ethanol_resistant def: "Animals fail to respond to the concentration of ethanol that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to ethanol to elicit the response compared to control animals." [WB:WBPaper00002358, WB:WBPaper00031371, WB:WBPerson557, WB:WBPerson712] synonym: "alcohol_resistant" BROAD [] synonym: "Jud" BROAD three_letter_name [] is_a: WBPhenotype:0000009 ! anesthetic_resistant [Term] id: WBPhenotype:0001613 name: paralysis_response_to_ethanol_resistant def: "Animals in the presence of ethanol continue to respond to touch under conditions when control worms have stopped responding to stimuli." [WB:WBPaper00031371, WB:WBPerson712] is_a: WBPhenotype:0001612 ! ethanol_resistant [Term] id: WBPhenotype:0001614 name: anticonvulsant_response_variant def: "Animals exhibit variations in their response to a specific anticonvulsant compared to that observed in control animals." [WB:WBPerson557] synonym: "anticonvulsant_response_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001615 name: anticonvulsant_resistant def: "Animals fail to respond to the concentration of compounds that act as anticonvulsants that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00024698, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000011 ! drug_resistant is_a: WBPhenotype:0001614 ! anticonvulsant_response_variant [Term] id: WBPhenotype:0001616 name: trimethadione_resistant def: "Animals fail to respond to the concentration of trimethadione, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00024698, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0001615 ! anticonvulsant_resistant [Term] id: WBPhenotype:0001617 name: ethosuximide_resistant def: "Animals fail to respond to the concentration of ethosuximide, which acts as an anticonvulsant, that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPerson712] is_a: WBPhenotype:0001615 ! anticonvulsant_resistant [Term] id: WBPhenotype:0001618 name: halothane_resistant def: "Animals fail to respond to the concentration of the anesthetic halothane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00004721, WB:WBPerson557, WB:WBPerson712] is_a: WBPhenotype:0000009 ! anesthetic_resistant [Term] id: WBPhenotype:0001619 name: isoflurane_resistant def: "Animals fail to respond to the concentration of the volatile anesthetic isoflurane that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00004721, WB:WBPerson712] is_a: WBPhenotype:0000009 ! anesthetic_resistant [Term] id: WBPhenotype:0001620 name: organism_oxidative_stress_response_variant def: "Animals exhibit variations in their response to oxidative stress compared to that observed in control animals." [WB:WBPerson557] synonym: "organism_oxidative_stress_response_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0001621 name: organism_oxidative_stress_response_hypersensitive def: "Animals respond to a lower concentration of reactive oxygen species or a shorter exposure compared to control animals." [WB:WBPerson2021] is_a: WBPhenotype:0001620 ! organism_oxidative_stress_response_variant [Term] id: WBPhenotype:0001622 name: egg_laying_serotonin_hypersensitive def: "Animals lay eggs at a greater rate in response to exogenous serotonin compared to control animals." [WB:WBPaper00002487, WB:WBPerson712] is_a: WBPhenotype:0000023 ! serotonin_hypersensitive is_a: WBPhenotype:0001629 ! egg_laying_serotonin_variant [Term] id: WBPhenotype:0001623 name: male_tail_curling_serotonin_variant def: "Any variation in the posture of the male tail after application of exogenous serotonin compared to control. In C. elegans, males respond with a tight ventral curling of the male tail in response to serotonin." [WB:WBPaper00001861, WB:WBPerson557] synonym: "male_tail_curling_serotonin_abnormal" NARROW [] is_a: WBPhenotype:0001232 ! serotonin_response_variant [Term] id: WBPhenotype:0001624 name: male_tail_curling_serotonin_resistant def: "Animals fail to respond to the concentration of serotonin that elicits a male tail curling response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body." [WB:WBPaper00001861, WB:WBPerson557] is_a: WBPhenotype:0000024 ! serotonin_resistant is_a: WBPhenotype:0001623 ! male_tail_curling_serotonin_variant [Term] id: WBPhenotype:0001625 name: male_tail_curling_serotonin_hypersensitive def: "Males respond to serotonin by curling their tails at a lower concentration or a shorter exposure compared to control animals. In C. elegans males respond to serotonin with a tight ventral curling of the male tail and posterior body." [WB:WBPaper00001861, WB:WBPaper00028762, WB:WBPerson557] is_a: WBPhenotype:0000023 ! serotonin_hypersensitive is_a: WBPhenotype:0001623 ! male_tail_curling_serotonin_variant [Term] id: WBPhenotype:0001626 name: locomotion_rate_serotonin_variant def: "Any variation in the locomotion rate after application of exogenous serotonin compared to control." [WB:WBPaper00002141] synonym: "locomotion_rate_serotonin_abnormal" NARROW [] is_a: WBPhenotype:0001232 ! serotonin_response_variant [Term] id: WBPhenotype:0001627 name: locomotion_rate_serotonin_hypersensitive def: "The decrease in locomotion rate in the presence of serotonin is greater than control animals." [WB:WBPaper00002141] synonym: "locomotion rate serotonin reduced" RELATED [] is_a: WBPhenotype:0000023 ! serotonin_hypersensitive is_a: WBPhenotype:0001626 ! locomotion_rate_serotonin_variant [Term] id: WBPhenotype:0001628 name: locomotion_rate_serotonin_resistant def: "Animals fail to decrease their locomotion rate in response the concentration of serotonin that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals." [WB:WBPaper00002141] synonym: "locomotion rate serotonin increased" RELATED [] is_a: WBPhenotype:0000024 ! serotonin_resistant is_a: WBPhenotype:0001626 ! locomotion_rate_serotonin_variant [Term] id: WBPhenotype:0001629 name: egg_laying_serotonin_variant def: "Any variation in egg laying behavior after application of exogenous serotonin compared to control. In C. elegans, serotonin induces egg laying." [WB:WBPaper00000635, WB:WBPerson712] synonym: "egg_laying_serotonin_abnormal" NARROW [] is_a: WBPhenotype:0001101 ! egg_laying_response_to_drug_variant is_a: WBPhenotype:0001232 ! serotonin_response_variant [Term] id: WBPhenotype:0001630 name: gut_obstructed def: "Any variation in the developmental progression of the intestine that leads to a blockage in the alimentary canal." [WB:WBPerson2021, WB:WBPerson557] synonym: "Gob" BROAD three_letter_name [] is_a: WBPhenotype:0000708 ! intestinal_development_variant [Term] id: WBPhenotype:0001631 name: nullo_X_gamete def: "Animals produce ova/sperm that contain no X chromosome in a nonmendelian segregation pattern." [WB:WBPaper00000179, WB:WBPerson712] synonym: "nullo_X_gamete_abnormal" NARROW [] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001632 name: diplo_X_gamete def: "Animals produce ova/sperm that contain 2 X chromosomes." [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001633 name: lethal_gamete def: "Animals produce ova/sperm that contain lethal factors as a result of chromosomal disjunction defects." [WB:WBPaper00000179, WB:WBPerson712] is_a: WBPhenotype:0001174 ! chromosome_disjunction_defective [Term] id: WBPhenotype:0001634 name: organism_electrophilic_stress_hypersensitive def: "Animals respond to compounds that elicit electrophilic stress at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0001635 name: excess_pharyngeal_cells def: "Animals contain an excess number of pharyngeal cells compared to control. In C. elegans, pharyngeal cells are derived from MS-blastomere. The overproduction of pharyngeal tissues is a result of other blastomeres adopting an MS-like fate." [WB:WBPaper00001584, WB:WBPaper00002922, WB:WBperson2021] is_a: WBPhenotype:0000707 ! pharyngeal_development_variant [Term] id: WBPhenotype:0001636 name: excess_intestinal_cells def: "Animals contain an excess number of intestinal cells compared to control. In C. elegans, intestinal cells are derived from E-blastomere. The overproduction of intestinal tissues is a result of other blastomeres adopting an E-like fate." [WB:WBPaper00001584, WB:WBPaper00002330, WB:WBperson2021] is_a: WBPhenotype:0000708 ! intestinal_development_variant [Term] id: WBPhenotype:0001637 name: no_Intestine def: "Embryos fail to generate cells that exhibit intestinal specification. In C. elegans, the E blastomere is the precursor of all the intestinal cells." [WB:WBPaper00002946, WB:WBperson2021] is_a: WBPhenotype:0000708 ! intestinal_development_variant [Term] id: WBPhenotype:0001638 name: endosome_fusion_defective def: "Animals are deficient in the formation or disassembly of lysosomes." [GO:0034058, WB:WBPaper00029049, WB:WBPerson712] is_a: WBPhenotype:0001422 ! endocytic_transport_defect [Term] id: WBPhenotype:0001639 name: roaming_reduced def: "Animals do not move more than a few body lengths from their starting position, searches occur locally with pivoting behavior." [WB:WBPaper00003743, WB:WBPaper00031455, WB:WBPerson712] synonym: "lurcher" RELATED [] is_a: WBPhenotype:0000238 ! foraging_reduced [Term] id: WBPhenotype:0001640 name: acidification_level_defective def: "Animals are unable to acidify compartments to the same level as that observed in control animals given the same stimulus." [WB:WBPaper00031246, WB:WBPerson712] synonym: "acidification_level_abnormal" NARROW [] is_a: WBPhenotype:0000607 ! coelomic_system_physiology_variant [Term] id: WBPhenotype:0001641 name: posterior_body_wall_contraction_defective def: "Animals lack or exhibit defects in the posterior body muscle contractions during the defecation cycle." [WB:WBPaper00031426, WB:WBPerson712] synonym: "pBoc" RELATED [] is_a: WBPhenotype:0000157 ! posterior_body_wall_contraction_defecation_cycle_variant [Term] id: WBPhenotype:0001642 name: cell_cleavage_variant_emb def: "Variations that disrupt stereotypical embryonic cleavage patterns (such as cleavage rate, division axes or asymmetric division)." [GO:0040016, WB:WBPaper00001032, WB:WBPerson2021] synonym: "cell_cleavage_abnormal" NARROW [] is_a: WBPhenotype:0001100 ! early_embryonic_lethal [Term] id: WBPhenotype:0001643 name: excess_hypodermal_cells def: "Embryos generate an excess number of hypodermal cells compared to control." [WB:WBPerson2021] synonym: "Skn" BROAD three_letter_name [] is_a: WBPhenotype:0000701 ! epithelial_development_variant [Term] id: WBPhenotype:0001644 name: protein_metabolism_variant def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of proteins in the organism compared to control." [WB:WBPerson557] synonym: "protein_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001645 name: protein_degradation_variant def: "Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control." [GO:0030163, WB:WBPerson2021] synonym: "protein_degradation_abnormal" NARROW [] is_a: WBPhenotype:0001644 ! protein_metabolism_variant [Term] id: WBPhenotype:0001646 name: no_pharynx def: "Embryos fail to generate cells that exhibit pharyngeal specification." [WB:WBPaper00001521, WB:WBPerson2021] is_a: WBPhenotype:0000707 ! pharyngeal_development_variant [Term] id: WBPhenotype:0001647 name: posterior_pharynx_variant def: "Any variation in the progression of the posterior portion of the pharynx over time compared to control. In C. elegans the posterior region includes the isthmus and terminal bulb (second bulb)." [WB:WBPerson2021, WB:WBPerson557] synonym: "posterior_pharynx_abnormal" NARROW [] is_a: WBPhenotype:0000707 ! pharyngeal_development_variant [Term] id: WBPhenotype:0001648 name: no_posterior_pharynx def: "Embryos fail to generate cells that give rise to the posterior portion of the pharynx. In C. elegans, the MS blastomere- derived pharyngeal cells constitute the posterior portion of the pharynx." [WB:WBPaper00002330, WB:WBPerson2021] is_a: WBPhenotype:0001646 ! no_pharynx is_a: WBPhenotype:0001647 ! posterior_pharynx_variant [Term] id: WBPhenotype:0001649 name: Fluorouracil_resistant def: "Animals fail to respond to the concentration of Fluorouracil (5-FU) that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. Elegans Fluorouracil induces germ cell death, inhibits embryogenesis and inhibits larval growth (depending on dose) in control animals." [WB:WBPaper00031571, WB:WBPerson721] synonym: "5_FU_resistant" EXACT [] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001650 name: germ_cell_death_response_to_5_FU_resistant def: "germ cell death fails in response to the concentration of 5-FU that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans, in addition to cell death, 5-FU exposed animals exhibit condensed germ cell nuclei or unhealthy nuclei." [WB:WBPaper00031571, WB:WBPerson721] is_a: WBPhenotype:0001649 ! Fluorouracil_resistant [Term] id: WBPhenotype:0001651 name: growth_arrest_response_to_5_FU_resistant def: "Animals grow well during or after exposure to 5-FU under conditions where control animals are growth inhibited." [WB:WBPaper00031571, WB:WBPerson721] is_a: WBPhenotype:0001649 ! Fluorouracil_resistant [Term] id: WBPhenotype:0001652 name: anchor_cell_invasion_variant def: "Any variation in the process by which the gonad anchor cell makes contact with vulval cells in order to create a uterine-vulval connection. In C. elegans, this includes the loss of the basement membranes between these cells and the crossing of the basolateral portion of the anchor cell through this gap." [WB:WBPaper00005989] synonym: "anchor_cell_invasion_abnormal" NARROW [] is_a: WBPhenotype:0000283 ! vulva_uterus_connection_defective [Term] id: WBPhenotype:0001653 name: cadmium_response_variant def: "Animals exhibit variations in their response to cadmium compared to that observed in control animals." [WB:WBPerson557] synonym: "cadmium_response_abnormal" NARROW [] is_a: WBPhenotype:0000591 ! metal_response_variant [Term] id: WBPhenotype:0001654 name: cadmium_resistant def: "Animals fail to respond to the concentration of cadmium that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to cadmium to elicit the response compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001653 ! cadmium_response_variant [Term] id: WBPhenotype:0001655 name: cadmium_hypersensitive def: "Animals respond to cadmium at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001653 ! cadmium_response_variant [Term] id: WBPhenotype:0001656 name: distal_tip_cell_development_variant def: "Any variation in the progression of the leader cell that guides and shapes the outgrowth of the gonad while crawling along the bodywall to force the germline to extend into a long tubular shape over time from its formation to its mature structure compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "distal_tip_cell_development_abnormal" NARROW [] is_a: WBPhenotype:0000399 ! somatic_gonad_development_variant [Term] id: WBPhenotype:0001657 name: cell_junction_variant def: "Animals exhibit variations in the specialized region of connection between two cells or between a cell and the extracellular matrix compared to control." [GO:0030054, WB:WBPaper00031590, WB:WBPerson712] synonym: "cell_junction_abnormal" NARROW [] is_a: WBPhenotype:0001399 ! cell_membrane_morphology_variant [Term] id: WBPhenotype:0001658 name: intercellular_junction_variant def: "Animals exhibit variations in the specialized region of connection between two cells compared to control." [GO:0005911, WB:WBPaper00031590, WB:WBPerson712] synonym: "cell_cell_junction_abnormal" RELATED [] synonym: "intercellular_junction_abnormal" NARROW [] is_a: WBPhenotype:0001657 ! cell_junction_variant [Term] id: WBPhenotype:0001659 name: spermatheca_morphology_variant def: "Any variation in the form, structure or composition of the somatic gonad structure that connects the distal gonad arm to the uterus compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "spermatheca_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_variant [Term] id: WBPhenotype:0001660 name: loss_of_asymmetry_ASE def: "The two morphologically bilaterally symmetric gustatory neurons ASE left (ASEL) and ASE right (ASER) fail to undergo a left/right asymmetric diversification in cell fate." [WB:WBPaper00030973, WB:WBPerson2021] synonym: "2ASEL" NARROW [] synonym: "2ASER" NARROW [] is_a: WBPhenotype:0001512 ! loss_of_left_right_neuronal_asymmetry [Term] id: WBPhenotype:0001661 name: loss_of_asymmetry_AWC def: "The two morphologically bilaterally symmetric olfactory neurons AWC left (AWCL) and AWC right (AWCR) fail to undergo a left/right asymmetric diversification in cell fate." [WB:WBPaper00003760, WB:WBPerson2021] synonym: "2 AWC off" NARROW [] synonym: "2 AWC on" NARROW [] is_a: WBPhenotype:0001512 ! loss_of_left_right_neuronal_asymmetry [Term] id: WBPhenotype:0001662 name: spermatheca_development_variant def: "Any variation in the progression of the somatic gonad structure that connects the distal gonad arm to the uterus over time from an initial condition to a later condition compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "spermatheca_development_abnormal" NARROW [] is_a: WBPhenotype:0000399 ! somatic_gonad_development_variant [Term] id: WBPhenotype:0001663 name: organism_oxidative_stress_resistant def: "Animals fail to respond to the levels of reactive oxygen species that elicit a response in control animals. " [WB:WBPerson2021] is_a: WBPhenotype:0001620 ! organism_oxidative_stress_response_variant [Term] id: WBPhenotype:0001664 name: X_chromosome_nondisjunction def: "The frequency of sex chromosome segregation is perturbed, resulting in the production of exceptional gametes (e.g. ova or sperm) and populations with a sex ratio altered from the rate of 1:500 as observed for control populations." [WB:WBPaper00000179, WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0001174 ! chromosome_disjunction_defective [Term] id: WBPhenotype:0001665 name: low_incidence_male_progeny def: "Lower numbers of male progeny occur in the population as a result of a decrease in the rate of X chromosome nondisjunction compared to control." [WB:WBPaper00000565, WB:WBPerson712] is_a: WBPhenotype:0001664 ! X_chromosome_nondisjunction [Term] id: WBPhenotype:0001666 name: organism_hypersensitive_X_ray_irradiation def: "Animals respond to iononizing radiation at a lower dose or a shorter exposure compared to control animals. Iononizing radiation has a wavelength in the 10 to 0.01 nanometer range. In C. elegans, increased sensitivity to X-ray irradiation is often observed as a decrease in survival upon exposure compared to control animals given the same treatment." [WB:WBPaper00000565, WB:WBPaper00003886, WB:WBPerson712] is_a: WBPhenotype:0000276 ! organism_X_ray_response_variant is_a: WBPhenotype:0000711 ! organism_hypersensitive_ionizing_radiation [Term] id: WBPhenotype:0001667 name: methyl_methanesulfonate_hypersensitive def: "Animals respond to the chemical mutagen methyl methanesulfonate (MMS) a methanesulfonate ester and alkylating agent at a lower concentration or a shorter exposure compared to control animals. In C. elegans, increased sensitivity to MMS can be observed as a decrease in egg hatch upon acute exposure or inhibition of growth after chronic exposure compared to control animals given the same treatment." [WB:WBPaper00000565, WB:WBPerson712] synonym: "MMS_hypersensitive" EXACT [] is_a: WBPhenotype:0000498 ! methyl_methanesulfonate_response_variant [Term] id: WBPhenotype:0001668 name: oocyte_accumulation def: "Oocytes are retained in the gonad without becoming endomitotic. In C. elegans, accumulated oocytes occur in a non-linear arrangement in the proximal gonad." [WB:WBPaper00006281, WB:WBPaper00030855] is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_variant [Term] id: WBPhenotype:0001669 name: presynaptic_vesicle_number_variant def: "Animals exhibit a variation in the ratio of synaptic vesicles per synapse of a neuron, compared to control animals." [WB:WBPaper00027305, WB:WBPerson712] synonym: "presynaptic_vesicle_number_abnormal" NARROW [] synonym: "synaptic_vesicle_number_abnormal" RELATED [] is_a: WBPhenotype:0001321 ! presynaptic_region_morphology_variant [Term] id: WBPhenotype:0001670 name: presynaptic_vesicle_number_reduced def: "Animals exhibit an overall decrease in the quantity of synaptic vesicles at the synapse compared to control animals." [WB:WBPaper00027305, WB:WBPerson712] synonym: "synaptic_vesicle_number_reduced" RELATED [] is_a: WBPhenotype:0001669 ! presynaptic_vesicle_number_variant [Term] id: WBPhenotype:0001671 name: vesicle_organization_variant def: "Animals display variations in the distribution of spherical membrane-bound fluid-filled organelles, compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "vesicle_organization_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0001672 name: commisure_growth_variant def: "Animals exhibit variations in the extension of the part of the axon that forms a bridge between body regions, compared to control animals." [WB:WBPerson2021, WB:WBPerson712] synonym: "commisure_growth_abnormal" NARROW [] is_a: WBPhenotype:0001224 ! axon_outgrowth_variant [Term] id: WBPhenotype:0001673 name: telomere_homeostasis_variant def: "Animals exhibit variations in the processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA, which allow the chromosome to persist from generation to generation, compared to control." [GO:0032204, WB:WBPaper00031585, WB:WBPerson712] synonym: "telomere_homeostasis_abnormal" NARROW [] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001674 name: telomere_morphology_variant def: "Animals exhibit variations in the sequence or organization of the components of the terminal region of its chromosome, (i.e. telomere, which serves to stabilize the chromosome) compared to control." [GO:0000781, WB:WBPaper00003886, WB:WBPerson712] synonym: "telomere_morphology_abnormal" NARROW [] is_a: WBPhenotype:0001348 ! chromosome_morphology_variant [Term] id: WBPhenotype:0001675 name: male_gonad_development_variant def: "Males exhibit variations in the reproductive system, from its formation to the mature structure compared to control." [WB:WBPerson712] synonym: "male_gonad_development_abnormal" NARROW [] is_a: WBPhenotype:0000691 ! gonad_development_variant [Term] id: WBPhenotype:0001676 name: touch_receptor_cell_morphology_variant def: "Animals exhibit variations in the structure or composition of any neuron within the class of sensory neurons responsible for relaying mechanical stimuli to the animal compared to control." [WB:WBPaper00000550, WB:WBPerson712] synonym: "mechanosensory_neuron_abnormal" RELATED [] synonym: "microtubule_cell_morphology_abnormal" RELATED [] synonym: "touch_receptor_cell_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000905 ! neuron_morphology_variant [Term] id: WBPhenotype:0001677 name: stage_specific_cuticle_antigenicity_variant def: "Animals display cuticle components displayed by animals of a different developmental stage, compared to control." [WB:WBPaper00002589, WB:WBPerson712] synonym: "Srf" NARROW [] synonym: "stage_specific_cuticle_antigenicity_abnormal" NARROW [] is_a: WBPhenotype:0001687 ! surface_antigenicity_variant [Term] id: WBPhenotype:0001678 name: cuticle_physiology_variant def: "Animals produce cuticles that vary in components such as proteins or carbohydrates, observed in control animals of the same developmental stage and raised under the same conditions." [WB:WBPaper00001576, WB:WBPerson712] synonym: "cuticle_physiology_abnormal" NARROW [] is_a: WBPhenotype:0001210 ! pericellular_component_physiology_variant [Term] id: WBPhenotype:0001679 name: multipolar_neuron def: "Neurons have more than one process extending from the cell body." [WB:WBPaper00031901, WB:WBPerson712] is_a: WBPhenotype:0000905 ! neuron_morphology_variant [Term] id: WBPhenotype:0001680 name: adoption_of_fused_vulval_cell_fate def: "Vulval precursor cells forgo further cell division and fuse to the hypodermis instead of adopting their intended fate (becoming primary, secondary or tertiary vulval cells)." [WB:WBPerson2021, WB:WBPerson712] synonym: "F_fate_abnormal " RELATED [] synonym: "VPC_competence" RELATED [] synonym: "VPC_fused_fate_abnormal" RELATED [] synonym: "vulval_precursor_cell_competence_abnormal" RELATED [] is_a: WBPhenotype:0001272 ! vulval_cell_induction_variant [Term] id: WBPhenotype:0001681 name: spindle_orientation_variant def: "The alignment of the spindle relative to other cellular structures varies from that observed in control animals." [GO:0051294, WB:WBPaper00031898, WB:WBPerson712] synonym: "spindle_orientation_abnormal" NARROW [] is_a: WBPhenotype:0001344 ! organelle_organization_biogenesis_variant [Term] id: WBPhenotype:0001682 name: organism_UV_resistant def: "Organisms respond to UV at a higer dose or a longer exposure compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000143 ! organism_UV_response_variant [Term] id: WBPhenotype:0001683 name: spermatogenesis_defective_hermaphrodite def: "Variations that specifically disrupt sperm production in XX hermaphrodites. By contrast, spermatogenesis in XO males remains unaffected." [WB:WBPaper00002113, WB:WBPaper00002631] is_a: WBPhenotype:0000670 ! spermatogenesis_variant [Term] id: WBPhenotype:0001684 name: synaptic_vesicle_homeostasis_variant def: "The rates of synaptic vesicle exocytosis and endocytosis vary from that observed in control animals." [WB:WBPaper00031872, WB:WBPerson712] synonym: "synaptic_vesicle_homeostasis_abnormal" NARROW [] is_a: WBPhenotype:0000846 ! presynaptic_region_physiology_variant [Term] id: WBPhenotype:0001685 name: postsynaptic_region_morphology_variant def: "The region opposite to the presynaptic region deviates in the structure, configuration or ratio of its components specific for receiving signals from the other side of the synapse compared to control." [WB:WBPaper00031872, WB:WBPerson712] synonym: "postsynaptic_region_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000616 ! synapse_morphology_variant [Term] id: WBPhenotype:0001686 name: postsynaptic_region_physiology_variant def: "Animals exhibit variations in any physical or chemical process in the region, opposite to the presynaptic region, which is required for receiving signals from the other side of the synapse compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "postsynaptic_region_physiology_abnormal" NARROW [] is_a: WBPhenotype:0000584 ! synaptic_transmission_variant [Term] id: WBPhenotype:0001687 name: surface_antigenicity_variant def: "Cuticles of animals or cuticular extracts exhibit an altered pattern of antibody binding compared to Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712] synonym: "Srf" EXACT [] synonym: "surface_antigenicity_abnormal" NARROW [] is_a: WBPhenotype:0001688 ! surface_coat_variant [Term] id: WBPhenotype:0001688 name: surface_coat_variant def: "The electron dense, amorphous envelope that comprises the outermost layer of the cuticle varies in composition from that observed in control animals of the same developmental stage. The integrity of the surface coat is often revealed by an altered antigenicity or biochemical make up." [GO:0060104] synonym: "Srf" EXACT [] synonym: "surface_coat_abnormal" NARROW [] is_a: WBPhenotype:0000201 ! cuticle_development_variant is_a: WBPhenotype:0001678 ! cuticle_physiology_variant [Term] id: WBPhenotype:0001689 name: surface_antigen_negative def: "Cuticles or cuticular extracts do not bind antibodies that are observed to bind the surfaces or cuticular extracts of Bristol N2 animals of the same developmental stage." [WB:WBPaper00001280, WB:WBPerson712] synonym: "Srf" NARROW [] is_a: WBPhenotype:0001687 ! surface_antigenicity_variant [Term] id: WBPhenotype:0001690 name: constitutive_larval_display def: "Animals display surface antigens throughout all larval stages, unlike Bristol N2 worms, which display the antigens only during one larval stage." [WB:WBPaper00002589, WB:WBPerson712] synonym: "Cld" BROAD three_letter_name [] is_a: WBPhenotype:0001677 ! stage_specific_cuticle_antigenicity_variant [Term] id: WBPhenotype:0001691 name: germ_nuclei_rachis def: "Germ nuclei are misplaced in the gonad and are observed in the rachis. Sheath cells are observed protruding between these nuclei. Meiotic or mitotic specification of germ nuclei is not affected." [WB:WBPaper00031889, WB:WBPerson712] synonym: "germ_line_morphogenesis(Glm)" NARROW [] synonym: "rachis_morphology_abnormal" NARROW [] is_a: WBPhenotype:0000977 ! somatic_gonad_morphology_variant [Term] id: WBPhenotype:0001692 name: pheromone_induced_larval_display_defective def: "Animals are not induced to display surface antigens by exposure to pheromone as observed for Bristol N2 animals." [WB:WBPaper00002589, WB:WBPerson712] synonym: "ILD_abnormal" EXACT [] synonym: "induced_larval_display_abnormal" RELATED [] synonym: "pheromone_induced_larval_display_abnormal" NARROW [] is_a: WBPhenotype:0001687 ! surface_antigenicity_variant [Term] id: WBPhenotype:0001693 name: male_posterior_alae def: "Males have alae that extend into the tail region.\nAlae are small linear ridges running along the lateral lines of the cuticle. In C. elegans alae do not extend into the tail region (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "Pal" BROAD three_letter_name [] is_a: WBPhenotype:0000202 ! alae_variant [Term] id: WBPhenotype:0001694 name: spermatogenesis_to_oogenesis_switch_defective def: "Hermaphrodites continue to produce sperm past the time at which the transition to oogenesis normally occurs. Thus, germ cells that would normally become oocytes are transformed into sperm instead." [WB:WBPaper00001883, WB:WBPaper00002113, WB:WBPerson2021] synonym: "spermatogenesis_to_oogenesis_switch_abnormal" NARROW [] is_a: WBPhenotype:0001572 ! masculinized [Term] id: WBPhenotype:0001695 name: glycosyltransferase_activity_variant def: "Animals exhibit variations in their catalytic ability the transfer glycolsyl groups from one compound (donor) to another (acceptor) often measured by a reduction in the amount of glycosylated products compared to that observed in control animals of the same developmental stage." [GO:0016757, WB:WBPerson712] synonym: "glycosyltransferase_activity_abnormal" NARROW [] is_a: WBPhenotype:0000733 ! catalysis_variant [Term] id: WBPhenotype:0001696 name: biosynthesis_variant def: "Animals exhibit variations in the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones compared to control." [GO:0009058, WB:WBPaper00029024, WB:WBPerson712] synonym: "biosynthesis_abnormal" NARROW [] is_a: WBPhenotype:0000463 ! metabolic_pathway_variant [Term] id: WBPhenotype:0001697 name: chondroitin_biosynthesis_variant def: "Animals exhibit variations in the chemical reactions and pathways resulting in the formation of chondroitin sulfate compared to control." [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712] synonym: "chondroitin_biosynthesis_abnormal" NARROW [] is_a: WBPhenotype:0001696 ! biosynthesis_variant [Term] id: WBPhenotype:0001698 name: heparan_sulfate_biosynthesis_variant def: "Animals exhibit variations in the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan compared to control" [WB:WBPaper00029024, WB:WBPaper00031153, WB:WBPerson712] synonym: "heparan_sulfate_biosynthesis_abnormal" NARROW [] is_a: WBPhenotype:0001696 ! biosynthesis_variant [Term] id: WBPhenotype:0001699 name: localized_movement_variant def: "Specific body regions of an animal display variations in movement compared to that observed in control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "localized_movement_abnormal" NARROW [] is_a: WBPhenotype:0001206 ! movement_variant [Term] id: WBPhenotype:0001700 name: swimming_variant def: "Animals exhibit variations in movement in liquid from that observed for control animals." [WB:WBPaper00031835, WB:WBPerson712] synonym: "movement_in_liquid_abnormal" RELATED [] synonym: "swimming_abnormal" NARROW [] synonym: "thrashing_abnormal" RELATED [] is_a: WBPhenotype:0001206 ! movement_variant [Term] id: WBPhenotype:0001701 name: spastic_locomotion def: "Animals exhibit uncharacteristic muscle contractions during the process by which they travel from one location to another. " [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0004017 ! locomotor_coordination_variant [Term] id: WBPhenotype:0001702 name: directionality_variant def: "Animals exhibit variations in the directional changes that separate consecutive runs, from that observed for control animals. In C. elegans, these aberrations include variations in the form or extent of omega turns or reversals (shifts from forward to backward movements)." [WB:WBPaper00000075, WB:WBPaper00003740, WB:WBPaper00031656, WB:WBPerson712] synonym: "directionality_abnormal" NARROW [] synonym: "reversal_abnormal" RELATED [] synonym: "turning_abnormal" RELATED [] is_a: WBPhenotype:0004017 ! locomotor_coordination_variant [Term] id: WBPhenotype:0001703 name: body_bend_variant def: "Any variation in the maximum ventral and dorsal flex of the animal compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "body_bend_abnormal" NARROW [] relationship: part_of WBPhenotype:0004018 ! sinusoidal_movement_variant [Term] id: WBPhenotype:0001704 name: multiple_alae def: "Alae contain more cuticular ridges than control animals. In C. elegans alae are composed of three cuticular ridges." [WB:WBPaper00026841, WB:WBPerson557] is_a: WBPhenotype:0001412 ! alae_morphology_variant [Term] id: WBPhenotype:0001705 name: nucleocytoplasmic_transport_defective def: "The directed movement of molecules between the nucleus and the cytoplasm is impaired" [GO:0006913, WB:WBPerson557] synonym: "nucleocytoplasmic_transport_abnormal" NARROW [] is_a: WBPhenotype:0001283 ! organelle_metabolism_variant [Term] id: WBPhenotype:0001706 name: nuclear_export_defective def: "The directed movement of substances out of the nucleus is impaired " [GO:0051168, WB:WBPerson557] synonym: "nuclear_export_abnormal" NARROW [] is_a: WBPhenotype:0001705 ! nucleocytoplasmic_transport_defective [Term] id: WBPhenotype:0001707 name: nuclear_import_defective def: "The directed movement of substances into the nucleus is impaired" [GO:0051170, WB:WBPerson557] synonym: "nuclear_import_abnormal" NARROW [] is_a: WBPhenotype:0001705 ! nucleocytoplasmic_transport_defective [Term] id: WBPhenotype:0001708 name: protein_export_from_nucleus_defective def: "The directed movement of a protein from the nucleus into the cytoplasm is impaired" [GO:0006611, WB:WBPerson557] synonym: "protein_export_from_nucleus_abnormal" NARROW [] is_a: WBPhenotype:0001706 ! nuclear_export_defective [Term] id: WBPhenotype:0001709 name: rhythmic_tolerance_to_stress_variant def: "Animals exhibit variations in light/dark cycle recurrence of reactions to stress conditions compared to that observed for control animals." [WB:WBPaper00032037, WB:WBPerson712] synonym: "circadian_variation_in_stress_tolerance_abnormal" RELATED [] synonym: "rhythmic_tolerance_to_stress_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant is_a: WBPhenotype:0001711 ! rhythmic_behavior_variant [Term] id: WBPhenotype:0001710 name: rhythmic_tolerance_to_osmotic_stress_variant def: "Animals exhibit variations in light/dark cycle recurrence of reactions to osmotic stress compared to that observed for control animals." [WB:WBPaper00032037, WB:WBPerson712] synonym: "rhythmic_tolerance_to_osmotic_stress_abnormal" NARROW [] is_a: WBPhenotype:0001709 ! rhythmic_tolerance_to_stress_variant [Term] id: WBPhenotype:0001711 name: rhythmic_behavior_variant def: "Animals exhibit variations in actions or responses that occur with measurable periodicity, from that observed for control animals." [GO:0007622, WB:WBPerson712] synonym: "rhythmic_behavior_abnormal" NARROW [] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0001712 name: circadian_rhythm_behavior_variant def: "Animals exhibit variations in the actions or reactions that recur with a periodicity associated with light/dark cycles, compared to control." [GO:0048512, WB:WBPaper00032037, WB:WBPerson712] synonym: "circadian_rhythm_behavior_abnormal" NARROW [] is_a: WBPhenotype:0001711 ! rhythmic_behavior_variant [Term] id: WBPhenotype:0001713 name: locomotory_rhythm_variant def: "Animals exhibit variations in locomotor activity during its light/dark cycle from that observed in control animals." [GO:0045475, WB:WBPaper00031656, WB:WBPerson712] synonym: "locomotory_rhythm_abnormal" NARROW [] is_a: WBPhenotype:0001711 ! rhythmic_behavior_variant [Term] id: WBPhenotype:0001714 name: pirouette_variant def: "Animals exhibit variations in turning bouts, consisting of one or more sharp turning events separating consecutive runs, which serve to orient the animal within a gradient, compared to control." [WB:WBPaper00003740, WB:WBPaper00026967, WB:WBPerson712] synonym: "pirouette_abnormal" NARROW [] is_a: WBPhenotype:0001702 ! directionality_variant [Term] id: WBPhenotype:0001715 name: pirouette_frequency_variant def: "Animals exhibit variations in the number of directional changes over time from that observed for control animals." [WB:WBPaper00031656, WB:WBPerson712] synonym: "frequency_of_directionality_abnormal" NARROW [] synonym: "pirouette_frequency_abnormal" NARROW [] is_a: WBPhenotype:0001714 ! pirouette_variant [Term] id: WBPhenotype:0001716 name: forward_point_velocity_variant def: "Animals exhibit variations in the translocation of any point along the animal's track from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson712] synonym: "forward_point_velocity_abnormal" NARROW [] is_a: WBPhenotype:0004025 ! velocity_of_movement_variant [Term] id: WBPhenotype:0001717 name: centroid_velocity_variant def: "Animals exhibit variations in the translocation of the mean position of the rear two-thirds (centroid position) of the animal over time, from that observed for control animals." [WB:WBPaper00024949, WB:WBPaper00031656, WB:WBPerson712] synonym: "centroid_velocity_abnormal" NARROW [] is_a: WBPhenotype:0004025 ! velocity_of_movement_variant [Term] id: WBPhenotype:0001718 name: instantaneous_velocity_variant def: "Animals exhibit variations in the mean translocation of the points along the animal's track compared to control." [WB:WBPaper00024949, WB:WBPerson712] synonym: "instantaneous_velocity_abnormal" NARROW [] is_a: WBPhenotype:0004025 ! velocity_of_movement_variant [Term] id: WBPhenotype:0001719 name: unfolded_protein_response_variant def: "Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER), compared to control. One such response is the increase in expression of chaperones." [GO:0030968, WB:WBPaper00030877, WB:WBPaper00032003, WB:WBPerson557, WB:WBPerson712] synonym: "ER_unfolded_protein_response_abnormal " RELATED [] synonym: "unfolded_protein_response" RELATED [] synonym: "unfolded_protein_response_abnormal" NARROW [] synonym: "UPR" RELATED [] is_a: WBPhenotype:0001485 ! ER_stress_response_variant [Term] id: WBPhenotype:0001720 name: spermatozoa_retro_location_defective def: "Spermatozoa do not crawl back into the spermatheca after being swept into the uterus by passing oocytes." [WB:WBPaper00032030, WB:WBPerson712] synonym: "spermatheca_homing_abnormal" RELATED [] synonym: "spermatozoa_retro_location_abnormal" NARROW [] is_a: WBPhenotype:0000389 ! hermaphrodite_sperm_fertilization_defective is_a: WBPhenotype:0001386 ! fertilization_defective_hermaphrodite [Term] id: WBPhenotype:0001721 name: pathogen_infected_pharynx_variant def: "Animals exhibit variations in the extent of pathogen invasion into the pharynx compared to control. This is often measured as the percentage of animals exhibiting a pathogen-invaded pharynx within a given population." [WB:WBPaper00032003, WB:WBPerson712] synonym: "pathogen_infected_pharynx_abnormal" NARROW [] is_a: WBPhenotype:0001012 ! organism_pathogen_response_variant [Term] id: WBPhenotype:0001722 name: pathogen_infected_pharynx_increase def: "Animals exhibit a greater extent of pathogen invasion into the pharynx compared to control." [WB:WBPaper00032003, WB:WBPerson712] is_a: WBPhenotype:0001721 ! pathogen_infected_pharynx_variant [Term] id: WBPhenotype:0001723 name: pathogen_infected_pharynx_decrease def: "Animals exhibit a lesser extent of pathogen invasion into the pharynx compared to control." [WB:WBPaper00032003, WB:WBPerson712] is_a: WBPhenotype:0001721 ! pathogen_infected_pharynx_variant [Term] id: WBPhenotype:0001724 name: tunicamycin_hypersensitive def: "Animals respond to tunicamycin at a lower concentration or a shorter exposure compared to control animals." [WB:WBPaper00030877, WB:WBPerson557] is_a: WBPhenotype:0000359 ! tunicamycin_response_variant [Term] id: WBPhenotype:0001725 name: osmotic_stress_response_variant def: "Animals exhibit variations in the response to osmotic stress compared to control. In C. elegans, exposure to stress-inducing osmotic conditions invokes cellular changes, including transcriptional up or down-regulation of genes." [WB:WBPaper00032031, WB:WBPerson712] synonym: "osmotic_stress_response_abnormal" NARROW [] is_a: WBPhenotype:0000142 ! cell_stress_response_variant [Term] id: WBPhenotype:0001726 name: body_length_variant def: "Animals vary in the distance between anterior and posterior ends of the animal from that observed in control animals." [WB:WBPerson712] synonym: "body_length_abnormal" NARROW [] is_a: WBPhenotype:0000231 ! body_size_variant [Term] id: WBPhenotype:0001727 name: body_width_variant def: "Animals vary in the distance between dorsal and ventral sides when measured across the body at right angles to the length, from that observed in control animals." [WB:WBPerson712] synonym: "body_width_abnormal" NARROW [] is_a: WBPhenotype:0000231 ! body_size_variant [Term] id: WBPhenotype:0001728 name: mating_plug_production_variant def: "Males differ from control animals in their ability to form copulatory plugs. In C. elegans, males of the Hawaiian strain (CB4856) typically form mating plugs." [WB:WBPaper00032027, WB:WBPerson712] synonym: "mating_plug_production_abnormal" NARROW [] is_a: WBPhenotype:0000928 ! male_physiology_variant [Term] id: WBPhenotype:0001729 name: mating_plug_produced def: "Males form copulatory mating plugs." [WB:WBPaper00002770, WB:WBPerson712] synonym: "mating_plug_plus" RELATED [] synonym: "plug_plus" RELATED [] is_a: WBPhenotype:0001728 ! mating_plug_production_variant [Term] id: WBPhenotype:0001730 name: mating_plug_deficient def: "Males do not form copulatory mating plug." [WB:WBPaper00002770, WB:WBPerson712] synonym: "mating_plug_minus" RELATED [] synonym: "plug_minus" RELATED [] is_a: WBPhenotype:0001728 ! mating_plug_production_variant [Term] id: WBPhenotype:0001731 name: thermal_bias_in_tracking_variant def: "Animals exhibit variations in the duration of the trajectory of the forward track in a thermal gradient compared to control." [WB:WBPaper00032070, WB:WBPerson712] synonym: "cryophilic_bias" RELATED [] synonym: "thermal_bias_in_tracking_abnormal" NARROW [] is_a: WBPhenotype:0000478 ! isothermal_tracking_behavior_variant [Term] id: WBPhenotype:0001732 name: organism_response_to_pH_variant def: "Animals exhibit variations in their response and ability to survive over a range of pH conditions compared to control." [WB:WBPaper00032033, WB:WBPerson712] synonym: "organism_response_to_pH_abnormal" NARROW [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0001733 name: pheromone_suppressed_pumping_defective def: "Animals treated with pheromone do not exhibit a decrease in pumping rate similar to that observed for control animals." [WB:WBPaper00032082, WB:WBPerson712] synonym: "pheromone_suppressed_pumping_abnormal" NARROW [] is_a: WBPhenotype:0001287 ! suppressed_pharyngeal_pumping_defective [Term] id: WBPhenotype:0001734 name: starvation_suppressed_pumping_defective def: "Animals deprived of food do not exhibit a decrease in pumping rate similar to that observed for control animals." [WB:WBPaper00032082, WB:WBPerson712] synonym: "food_deprived_suppression_of_pumping_abnormal" RELATED [] synonym: "starvation_suppressed_pumping_abnormal" NARROW [] is_a: WBPhenotype:0001287 ! suppressed_pharyngeal_pumping_defective [Term] id: WBPhenotype:0001735 name: muscle_cell_activity_variant def: "Animals exhibit variations in the frequency, rate or extent of muscle contraction compared to control animals." [GO:0006937, WB:WBPaper00032000, WB:WBPerson712] synonym: "muscle_cell_activity_abnormal" NARROW [] is_a: WBPhenotype:0000990 ! muscle_cell_physiology_variant [Term] id: WBPhenotype:0001736 name: acetate_chemotaxis_defective def: "Failure to execute the characteristic response to acetate compared to control animals." [WB:WBPaper00031959, WB:WBPerson712] is_a: WBPhenotype:0000015 ! positive_chemotaxis_defective [Term] id: WBPhenotype:0001737 name: aqueous_compound_discrimination_defective def: "Animals are unable to locate the gradient peak of a water soluble compound, which was generated on a uniform concentration of another compound." [WB:WBPaper00031959, WB:WBPerson712] synonym: "aqueous_compound_discrimination_abnormal" NARROW [] is_a: WBPhenotype:0001443 ! aqueous_chemosensory_response_variant [Term] id: WBPhenotype:0001738 name: ammonium_chemotaxis_defective def: "Failure to execute the characteristic response to ammonium compared to control animals." [WB:WBPaper00031959, WB:WBPerson712] is_a: WBPhenotype:0000015 ! positive_chemotaxis_defective [Term] id: WBPhenotype:0001739 name: aging_variant def: "Any variation in an organism's decline over time from its optimal fertility and viability compared to control animals." [WB:WBPaper00032067, WB:WBPerson712] synonym: "aging_abnormal" NARROW [] is_a: WBPhenotype:0000576 ! organism_physiology_variant [Term] id: WBPhenotype:0001740 name: organ_senescence_variant def: "Any variation in the preprogrammed process that occurs in an organism that is associated with the dismantling of an organ and an overall decline in metabolic function compared to control animals. This may include variations in the rate or extent of morphological disarray and of the breakdown or organelles, membranes and other cellular components." [GO:0010260, WB:WBPaper00032067, WB:WBPerson712] synonym: "organ_senescence_abnormal" NARROW [] is_a: WBPhenotype:0000530 ! organ_system_development_variant is_a: WBPhenotype:0000534 ! organ_system_morphology_variant is_a: WBPhenotype:0000575 ! organ_system_physiology_variant is_a: WBPhenotype:0001739 ! aging_variant [Term] id: WBPhenotype:0001741 name: spontaneous_spicule_protraction def: "Males exhibit spicule-muscle seizures leading to inappropriately timed protraction compared to control." [WB:WBPaper00032000, WB:WBPerson712] synonym: "precocious_spicule_protraction" RELATED [] is_a: WBPhenotype:0000279 ! spicule_insertion_defective [Term] id: WBPhenotype:0001742 name: lipid_synthesis_increased def: "The endogenous anabolism of any lipid species has been increased compared to that observed in control animals." [WB:WBPaper00032082, WB:WBPerson712] is_a: WBPhenotype:0000725 ! lipid_metabolism_variant [Term] id: WBPhenotype:0001743 name: mitosis_variant def: "Any variation in the division of the eukaryotic cell nucleus to produce two daughter nuclei that contain the identical chromosome complement of their mother compared to control." [GO:0007067, WB:WBPerson557] synonym: "mitosis_abnormal" NARROW [] is_a: WBPhenotype:0000746 ! cell_division_variant [Term] id: WBPhenotype:0001744 name: cell_adhesion_variant def: "Any variation in the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix compared to control." [GO:0007155, WB:WBPerson557] synonym: "cell_adhesion_abnormal" NARROW [] is_a: WBPhenotype:0001657 ! cell_junction_variant [Term] id: WBPhenotype:0001745 name: adherens_junction_variant def: "Any variation in a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments compared to control." [GO:0005912, WB:WBPerson557] synonym: "adherens_junction_abnormal" NARROW [] is_a: WBPhenotype:0001658 ! intercellular_junction_variant [Term] id: WBPhenotype:0001746 name: tight_junction_defective def: "Any perturbation in the belt-like region of very close contact between the plasma membranes of adjacent cells that results in the complete occlusion of the intercellular space." [GO:0005923, WB:WBPerson557] synonym: "tight_junction_abnormal" NARROW [] synonym: "zonula_occludens_abnormal" EXACT [] is_a: WBPhenotype:0001658 ! intercellular_junction_variant [Term] id: WBPhenotype:0001747 name: zinc_response_variant def: "Animals exhibit variations in the change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus compared to control." [GO:0010043, WB:WBPerson712] synonym: "zinc_response_abnormal" NARROW [] is_a: WBPhenotype:0000591 ! metal_response_variant [Term] id: WBPhenotype:0001748 name: pharynx_unattached def: "The pharynx is detached from the mouth." [WB:WBPaper00031910, WB:WBPerson712] synonym: "Pun" EXACT [] is_a: WBPhenotype:0000707 ! pharyngeal_development_variant [Term] id: WBPhenotype:0001749 name: zinc_toxicity_hypersensitive def: "The toxic response to zinc occurs at a lower concentration or a shorter exposure compared to control animals. In C. elegans hypersensitive animals exhibit delayed development or lethality at concentrations of zinc (e.g. ZnSO4), which has little or no effect on control worms." [WB:WBPaper00031911, WB:WBPerson712] is_a: WBPhenotype:0001747 ! zinc_response_variant [Term] id: WBPhenotype:0001750 name: zinc_toxicity_resistant def: "Animals fail to exhibit toxicity to the concentration of zinc that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. In C. elegans toxic responses to zinc include delayed development or lethality." [WB:WBPaper00031911, WB:WBPerson712] is_a: WBPhenotype:0001747 ! zinc_response_variant [Term] id: WBPhenotype:0001751 name: organism_hypertonic_lethality_increased def: "Animals exhibit increased lethality as a result of exposure to environments with a higher solute concentration than their own internal environment, compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "Hos" RELATED [] synonym: "hypertonic sensitive" RELATED [] is_a: WBPhenotype:0000141 ! stress_induced_lethality_increased is_a: WBPhenotype:0000876 ! organism_osmotic_stress_response_variant [Term] id: WBPhenotype:0001752 name: vesicle_trafficking_variant def: "Animals exhibit variations in vesicle-based directed movement of substances into, out of, or within a cell compared to control." [GO:0016192, WB:WBPerson712] synonym: "vesicle_trafficking_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0001753 name: coelomocyte_uptake_increased def: "Animals exhibit intensified accumulation of fluids or fluorescent markers etc. within their coelomocytes compared to control animals." [WB:WBPaper00004883, WB:WBPerson712] is_a: WBPhenotype:0001426 ! coelomocyte_uptake_defective [Term] id: WBPhenotype:0001754 name: endosome_to_lysosome_trafficking_defective def: "Contents of endosomes fail to be transported to lysosomal compartments." [WB:WBPaper00029049, WB:WBPerson712] is_a: WBPhenotype:0001421 ! endocytic_transport_variant [Term] id: WBPhenotype:0001755 name: UV_induced_mitotic_germ_cell_arrest_defective def: "Animals do not arrest mitotic germ cell division, as control animals, when treated with UV radiation." [WB:WBPaper00028948, WB:WBPerson557] is_a: WBPhenotype:0000100 ! cell_UV_response_variant [Term] id: WBPhenotype:0001756 name: UV_induced_apoptosis_decreased def: "Programmed cell death caused by UV radiation is reduced compared to control animals. In C. elegans, this is often measured in the pachytene region of the gonad." [WB:WBPaper00028948, WB:WBPerson557] is_a: WBPhenotype:0000100 ! cell_UV_response_variant [Term] id: WBPhenotype:0001757 name: neuropeptide_metabolism_variant def: "Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of signalling peptides in the organism compared to control." [WB:WBPerson712] synonym: "neuropeptide_metabolism_abnormal" NARROW [] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0001758 name: neuropeptide_processing_variant def: "Variations in the chemical reactions and pathways involved in the formation and maturation of specialized peptidergic neurotransmitters encoded as preproproteins that are posttranslationally processed to yield bioactive neuropeptides compared to control (Wormatlas)." [WB:WBPerson2021, WB:WBPerson557] synonym: "neuropeptide_processing_abnormal" NARROW [] is_a: WBPhenotype:0000122 ! post_translational_processing_variant is_a: WBPhenotype:0001757 ! neuropeptide_metabolism_variant [Term] id: WBPhenotype:0001759 name: 21U_RNA_expression_variant def: "Variations in the biogenesis or stability of the 21U-RNA class of molecules compared to control. Molecules are classified as 21U-RNA based on the presence of a 5'U and a conserved upstream motif, which may specify the production of these molecules, in addition these molecules are typically 21nt in length." [GO:0016070, WB:WBPaper00028915, WB:WBPaper00031962, WB:WBPerson712] synonym: "21U_RNA_expression_abnormal" NARROW [] synonym: "piRNA_expression_abnormal" RELATED [] is_a: WBPhenotype:0000113 ! RNA_expression_variant [Term] id: WBPhenotype:0001760 name: G_tract_instability def: "Animals exhibit an increase in the rate of deletion events in mono-G or G-rich tracts within the genome compared to control." [WB:WBPaper00031945, WB:WBPerson712] is_a: WBPhenotype:0000000 ! chromosome_instability [Term] id: WBPhenotype:0001761 name: axon_midline_crossing_variant def: "Regulated ventral midline crossing by axons vary either in the frequency of crossing events or the maintenance through development of process positions compared to control." [GO:0016199, WB:WBPaper00032007, WB:WBPerson712] synonym: "axon_midline_crossing_abnormal" NARROW [] is_a: WBPhenotype:0000384 ! axon_guidance_variant [Term] id: WBPhenotype:0001762 name: uptake_of_yolk_defective def: "Yolk is not taken up by oocytes in the same manner or to the same degree as observed for control animals. This often leads to an accumulation of yolk in the pseudocoelom." [WB:WBPaper00003831, WB:WBPerson712] is_a: WBPhenotype:0001422 ! endocytic_transport_defect is_a: WBPhenotype:0001424 ! oocyte_physiology_variant [Term] id: WBPhenotype:0001763 name: uptake_by_intestinal_cell_defective def: "Uptake of subtances from the intestine is altered from that observed in control animals." [WB:WBPaper00004883, WB:WBPerson712] is_a: WBPhenotype:0000986 ! epithelial_cell_physiology_variant is_a: WBPhenotype:0001422 ! endocytic_transport_defect [Term] id: WBPhenotype:0001764 name: carbon_dioxide_response_variant def: "Animals exhibit variations in their response to carbon dioxide compared to control." [WB:WBPerson712] synonym: "carbon_dioxide_response_abnormal" NARROW [] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0001765 name: carbon_dioxide_avoidance_variant def: "Variations in the characteristic movement away from specific CO2 levels compared to control. C. elegans avoids high levels of CO2." [WB:WBPaper00031935, WB:WBPerson557, WB:WBPerson712] synonym: "carbon_dioxide_avoidance_abnormal" NARROW [] synonym: "Cdad" RELATED [] synonym: "CO2_avoidance_abnormal" RELATED [] is_a: WBPhenotype:0001764 ! carbon_dioxide_response_variant [Term] id: WBPhenotype:0001766 name: cholesterol_depletion_hypersensitive def: "Animals are more sensitive to the reduction of cholesterol in the environment compared to control animals." [GO:0042632, WB:WBPaper00026641, WB:WBPerson712] is_a: WBPhenotype:0000725 ! lipid_metabolism_variant [Term] id: WBPhenotype:0001767 name: commissure_handedness_defective def: "Outgrowth of the commissure occurs on the side of the body different from that observed in control animals." [WB:WBPaper00032007, WB:WBPerson712] is_a: WBPhenotype:0000181 ! axon_trajectory_variant is_a: WBPhenotype:0000384 ! axon_guidance_variant [Term] id: WBPhenotype:0001768 name: commissure_number_variant def: "Variations in the quantity of circumferential axonal tracts from the number observed in control animals." [WB:WBPaper00032007, WB:WBPerson712] synonym: "commissure_number_abnormal" NARROW [] is_a: WBPhenotype:0001226 ! commissure_variant [Term] id: WBPhenotype:0001769 name: cytoplasmic_RNAi_defective def: "Animals fail to silence cytoplasmic-localized RNAs. Nuclear-localized RNAs may still be sensitive to RNAi." [WB:WBPaper00032049, WB:WBPerson712] is_a: WBPhenotype:0000743 ! RNAi_response_variant [Term] id: WBPhenotype:0001770 name: endo_siRNA_binding_variant def: "Animals exhibit variations in their selective interactions with small interfering RNA molecules compared to control." [GO:0035197, WB:WBPaper00032049, WB:WBPerson712] synonym: "endo_siRNA_binding_abnormal" NARROW [] is_a: WBPhenotype:0000743 ! RNAi_response_variant [Term] id: WBPhenotype:0001771 name: endo_siRNA_production_variant def: "Animals exhibit variations in the length or amount of any endogenous small interfering RNA molecule populations compared to control." [WB:WBPaper00031932, WB:WBPaper00032049, WB:WBPerson712] synonym: "endo_siRNA_production_abnormal" NARROW [] is_a: WBPhenotype:0000743 ! RNAi_response_variant [Term] id: WBPhenotype:0001772 name: endogenous_transposase_levels_increased def: "Animals exhibit an increase in the levels of transposase mRNA, from endogenous transposons, over that measured in control animals." [WB:WBPaper00031962, WB:WBPerson712] is_a: WBPhenotype:0000745 ! transposon_silencing_variant [Term] id: WBPhenotype:0001773 name: enhanced_locomotion_defective def: "Animals do not exhibit an increase in speed when placed in an environment that relies on a combination of swimming and crawling behaviors compared to control." [WB:WBPaper00031965, WB:WBPerson712] is_a: WBPhenotype:0001206 ! movement_variant [Term] id: WBPhenotype:0001774 name: gut_on_the_exterior def: "An epidermal enclosure defect that results in internal organs lying on the outside of the embryo." [WB:WBPaper00005123, WB:WBPaper00032090, WB:WBPerson712] synonym: "Gex" EXACT [] is_a: WBPhenotype:0000047 ! gastrulation_variant [Term] id: WBPhenotype:0001775 name: hormetic_temperature_induced_life_span_extension_defective def: "Pre-treatment with stress-inducing temperatures does not result in a life-span extension as it does in control animals." [WB:WBPaper00028750, WB:WBPaper00031942, WB:WBPerson712] is_a: WBPhenotype:0000061 ! extended_life_span is_a: WBPhenotype:0000146 ! organism_temperature_response_variant [Term] id: WBPhenotype:0001776 name: siRNA_expression_variant def: "Variations in the biogenesis and stability of the small interfering class of RNA molecules compared to control. In C. elegans these molecules are antisense to mRNA's and may be processed from long double-stranded RNA." [GO:0016070, WB:WBPaper00028915, WB:WBPaper00031962, WB:WBPerson712] synonym: "siRNA_expression_abnormal" NARROW [] is_a: WBPhenotype:0000113 ! RNA_expression_variant [Term] id: WBPhenotype:0001777 name: pre_mRNA_levels_increased def: "Animals exhibit an increase in the levels of nuclear mRNA species compared to control." [WB:WBPaper00032049, WB:WBPerson712] is_a: WBPhenotype:0000113 ! RNA_expression_variant [Term] id: WBPhenotype:0001778 name: nuclear_RNAi_defective def: "Animals fail to silence nuclear-localized RNAs. Animals still retain sensitivity to RNAi for those RNAs located outside of the nucleus." [WB:WBPaper00032049, WB:WBPerson712] is_a: WBPhenotype:0000743 ! RNAi_response_variant [Term] id: WBPhenotype:0001779 name: miRNA_expression_variant def: "Variations in the biogenesis or stability of the microRNA class of molecules compared to control. In C. elegans these molecules are endogenous single-stranded regulatory molecules, 19-25 nucleotides long, with the potential to arise from hairpin, foldback, structures from their primary transcripts." [GO:0035196, WB:WBPaper00028915, WB:WBPaper00029181, WB:WBPaper00030747, WB:WBPaper00031962, WB:WBPerson712] synonym: "miRNA_expression_abnormal" NARROW [] is_a: WBPhenotype:0000113 ! RNA_expression_variant [Term] id: WBPhenotype:0001780 name: associative_learning_variant def: "Variations in the behavioral plasticity induced by the integration of two sensory signals compared to control. In C. elegans animals exhibit enhancement of butanone chemotaxis by preexposure to butanone and food." [WB:WBPaper00029060, WB:WBPerson2021] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0001781 name: hypersensitivity_to_mutagen def: "Animals are more susceptible than control animals to the effects of a nucleic acid damaging agent. This increased susceptibility is often measured by an increase in the rate of spontaneous mutations or an increased lethality." [WB:WBPaper00031945, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001782 name: anoxia_response_attenuated def: "Response to low or diminishing levels of oxygen is reduced or weakened compared to the response of control animals." [WB:WBPaper00031981, WB:WBPerson712] synonym: "hypoxia_response_attenuated" RELATED [] is_a: WBPhenotype:0000464 ! oxygen_response_variant [Term] id: WBPhenotype:0001783 name: ligand_gated_channel_activity_variant def: "Animals exhibit variations in the actions of a channel that catalyses the transmembrane transfer of a cation when acetylcholine has been bound by the channel complex or one of its constituent parts compared to control animals." [GO:0022834, WB:WBPaper00031930, WB:WBPerson712] synonym: "ligand_gated_channel_activity_abnormal" NARROW [] is_a: WBPhenotype:0000631 ! drug_response_variant is_a: WBPhenotype:0000656 ! acetylcholine_synaptic_transmission_variant [Term] id: WBPhenotype:0001784 name: lysosome_homeostasis_deficient def: "Animals are deficient in the formation or disassembly of lysosomes." [GO:0007040, WB:WBPaper00029049, WB:WBPerson712] is_a: WBPhenotype:0001344 ! organelle_organization_biogenesis_variant [Term] id: WBPhenotype:0001785 name: memory_retention_defective def: "Animals are deficient in their recalled and repeated responses to stimuli they are exposed to during learning and memory paradigms." [WB:WBPaper00031974, WB:WBPerson712] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0001786 name: neuronal_ion_channel_clustering_defective def: "Animals exhibit variations in the targeting, clustering and or maintenance of ion channels in distinct subcellular domains of the neuron compared to control animals." [GO:0045161, WB:WBPaper00031930, WB:WBPerson712] is_a: WBPhenotype:0000612 ! nervous_system_physiology_variant is_a: WBPhenotype:0000816 ! neuron_development_variant is_a: WBPhenotype:0000991 ! neuron_physiology_variant [Term] id: WBPhenotype:0001787 name: phototaxis_defective def: "Animals do not respond via directed movement to light stimuli in the same manner as control animals. In C. elegans, animals move away from light." [WB:WBPaper00031999, WB:WBPerson712] is_a: WBPhenotype:0000525 ! organism_behavior_variant [Term] id: WBPhenotype:0001788 name: resistant_to_mutagens def: "Animals survive longer than control animals after or during exposure to DNA damaging agents." [WB:WBPaper00031934, WB:WBPerson712] is_a: WBPhenotype:0000577 ! organism_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001789 name: temperature_influenced_life_span_variant def: "Life span of the animal is not influenced by changes in temperature in the same manner as control animals." [WB:WBPaper00031942, WB:WBPerson712] synonym: "temperature_independent_life_span" NARROW [] synonym: "temperature_influenced_life_span_abnormal" NARROW [] is_a: WBPhenotype:0000039 ! life_span_variant is_a: WBPhenotype:0000146 ! organism_temperature_response_variant [Term] id: WBPhenotype:0001790 name: thermoreceptor_currents_absent def: "Cooling or warming evoked changes in membrane currents are not observed." [WB:WBPaper00032060, WB:WBPerson712] synonym: "ThRC_absent " RELATED [] is_a: WBPhenotype:0000851 ! ciliated_neuron_physiology_variant [Term] id: WBPhenotype:0001791 name: defecation_cycle_temperature_compensation_variant def: "Animals exhibit variations in temperature dependent differences in the length of their defecation cycle. In C. elegans the length of the cycle is the same at different temperatures, showing temperature compensation." [WB:WBPaper00002315, WB:WBPerson712] synonym: "defecation_cycle_temperature_compensation_abnormal" NARROW [] is_a: WBPhenotype:0000207 ! defecation_cycle_variant [Term] id: WBPhenotype:0001792 name: nuclei_small def: "Nuclei of specific cells are smaller compared to control animals." [WB:WBPerson557] is_a: WBPhenotype:0001028 ! nuclear_appearance_variant [Term] id: WBPhenotype:0001793 name: aboc_expulsion_missing def: "The anterior body contraction and expulsion steps of the defecation cycle are absent; posterior body contractions are still present." [WB:WBPaper00002776, WB:WBPerson712] synonym: "Aex" RELATED [] is_a: WBPhenotype:0000391 ! defecation_missing_motor_steps [Term] id: WBPhenotype:0001794 name: cytoplasmic_processing_body_variant def: "Discrete foci within the cytoplasm containing congregations of mRNA translational suppression and degradation mechanisms vary in their arrangement, clustering or are otherwise not well-defined compared to control." [WB:WBPaper00031914, WB:WBPaper00032172, WB:WBPerson712] synonym: "cytoplasmic_processing_body_abnormal" NARROW [] synonym: "P_body_abnormal" RELATED [] is_a: WBPhenotype:0001300 ! germ_cell_cytoplasmic_morphology_variant [Term] id: WBPhenotype:0001795 name: microsatellite_instability def: "Animals exhibit variations in repeat lengths of microsatellite genomic sequences compared to control." [WB:WBPaper00031859, WB:WBPerson712] is_a: WBPhenotype:0000000 ! chromosome_instability [Term] id: WBPhenotype:0001796 name: organism_hypersensitive_interstrand_cross_link_agents def: "Animals exhibit increased sensitivity to interstrand cross-linking agents, such as HN2 (nitrogen mustard) and CDDP (cisplatin) compared to control. In C. elegans, increased sensitivity to these agents is often observed as a decrease in survival compared to control animals after exposure to the agent." [WB:WBPaper00031868, WB:WBPerson712] synonym: "interstrand_cross_link_agent_hypersensitive" RELATED [] is_a: WBPhenotype:0000067 ! organism_stress_response_variant [Term] id: WBPhenotype:0001797 name: pachytene_arrested_germline_nuclei def: "Germline nuclei do not progress through pachytene to diplotene." [WB:WBPaper00031914, WB:WBPerson712] is_a: WBPhenotype:0000313 ! meiotic_progression_during_oogenesis_variant [Term] id: WBPhenotype:0001798 name: inhibition_of_synaptogenesis_defective def: "The processes that inhibit the location or frequency of formation of synapses are downregulated resulting in the formation of synapses or synapse-like structures in areas of the neuron that are typically devoid of synapses in control animals." [GO:0051964, WB:WBPaper00032163, WB:WBPerson712] is_a: WBPhenotype:0000625 ! synaptogenesis_variant is_a: WBPhenotype:0000944 ! neurite_development_variant [Term] id: WBPhenotype:0001799 name: inhibition_of_synaptogenesis_hyperactive def: "The processes that inhibit the location or frequency of formation of synapses are upregulated compared to control." [GO:0051964, WB:WBPaper00032163, WB:WBPerson712] is_a: WBPhenotype:0000944 ! neurite_development_variant [Term] id: WBPhenotype:0001800 name: antimicrobial_gene_expression_variant def: "Changes in the levels of innate immune gene products in response to pathogen exposure are significantly different from that observed in control animals." [WB:WBPaper00031865, WB:WBPerson712] synonym: "antimicrobial_gene_expression_abnormal" NARROW [] is_a: WBPhenotype:0001012 ! organism_pathogen_response_variant [Term] id: WBPhenotype:0001801 name: axodendritic_polarity_variant def: "Animals fail to establish or maintain characteristics that delineate the dendrite from the axon. The exclusion of presynaptic components from the dendrite is one indication of axodendritic polarity." [WB:WBPaper00032163, WB:WBPerson712] synonym: "axodendritic_polarity_abnormal" NARROW [] is_a: WBPhenotype:0000944 ! neurite_development_variant [Term] id: WBPhenotype:0001802 name: body_wall_muscle_relaxation_defective def: "Animals fail to relax their body wall muscles to the same extent as muscles in control animals." [WB:WBPaper00032190, WB:WBPerson712] is_a: WBPhenotype:0000596 ! body_behavior_variant [Term] id: WBPhenotype:0001803 name: endosome_biogenesis_variant def: "Animals exhibit variations in the formation or disassembly of membrane bound organelles that traffic material between the plasma membrane and internal compartments of the cell, compared to control." [WB:WBPaper00032168, WB:WBPerson712] synonym: "endosome_biogenesis_abnormal" NARROW [] is_a: WBPhenotype:0001344 ! organelle_organization_biogenesis_variant [Term] id: WBPhenotype:0001804 name: fat_associated_bodies_reduced def: "Animals exhibit a decrease in the number of fat containing organelles compared to control. In C. elegans this number can be assayed by decreases in the number of Nile Red or BODIPY 493/503 staining bodies." [WB:WBPaper00032168, WB:WBPerson712] is_a: WBPhenotype:0001344 ! organelle_organization_biogenesis_variant [Term] id: WBPhenotype:0001805 name: mitochondria_vesiculated def: "Inner membrane of mitochondria are disconnected and form vesicular bodies." [GO:0007005, WB:WBPaper00032231, WB:WBPerson712] is_a: WBPhenotype:0001401 ! mitochondria_morphology_variant [Term] id: WBPhenotype:0001806 name: protein_stabilization_variant def: "Any variation in the ability of a protein to resist disintegration via chemical or physical modifications compared to control." [WB:WBPaper00029085, WB:WBPerson2021] synonym: "protein_stabilization_abnormal" NARROW [] is_a: WBPhenotype:0001644 ! protein_metabolism_variant [Term] id: WBPhenotype:0001807 name: alternative_splicing_variant def: "Any variation in the process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition compared to control." [GO:0000380, WB:WBPerson557] synonym: "alternative_splicing_abnormal" NARROW [] is_a: WBPhenotype:0000028 ! RNA_processing_variant [Term] id: WBPhenotype:0001808 name: cell_corpse_digestion_variant def: "The degradation of genomic and or cellular material of the corpse does not occur at the same rate or under the same conditions as observed in control animals undergoing cell death." [WB:WBPaper00032272, WB:WBPerson712] synonym: "cell_corpse_digestion_abnormal" NARROW [] is_a: WBPhenotype:0000885 ! engulfment_variant [Term] id: WBPhenotype:0001809 name: organelle_fusion_defective def: "The formation of mature intracellular compartments via membrane fusion is disrupted." [WB:WBPaper00032272, WB:WBPerson712] is_a: WBPhenotype:0001344 ! organelle_organization_biogenesis_variant [Term] id: WBPhenotype:0001810 name: oocyte_septum_formation_variant def: "Animals exhibit variations in the partitioning of oocytes from each other compared to control animals." [WB:WBPaper00028947] synonym: "oocyte_cellularization_defective" RELATED [] synonym: "oocyte_septum_formation_abnormal" NARROW [] is_a: WBPhenotype:0000399 ! somatic_gonad_development_variant [Term] id: WBPhenotype:0001811 name: serotonin_induced_fat_reduction_variant def: "Animals retain a significantly greater proportion of their fat upon serotonin treatment, compared to control." [WB:WBPaper00031915, WB:WBPerson2021] synonym: "serotonin_induced_fat_reduction_abnormal" NARROW [] synonym: "serotonin_induced_fat_regulation" RELATED [] is_a: WBPhenotype:0000024 ! serotonin_resistant is_a: WBPhenotype:0001232 ! serotonin_response_variant [Term] id: WBPhenotype:0001812 name: embryonic_rupture def: "During development of the embryo, the epidermis loses integrity and the contents of the embryo are expelled." [WB:WBPerson557] is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0001813 name: synapsis_defective def: "Animals exhibit defects in the stabilization of homologue pairing, which occurs through the initiation and formation of the synaptonemal complex, during meiosis." [WB:WBPaper00032296, WB:WBPerson712] is_a: WBPhenotype:0000775 ! meiosis_variant [Term] id: WBPhenotype:0001814 name: crossover_defective def: "Animals exhibit defects in the number or extent of connections between chromatids that occur during the process of genetic material exchange between homologous segments of non-sister chromatids." [GO:0051026, WB:WBPaper00032296, WB:WBPerson712] synonym: "chiasma_defective" RELATED [] synonym: "homologous_recombination_foci_variant" RELATED [] is_a: WBPhenotype:0000775 ! meiosis_variant [Term] id: WBPhenotype:0001815 name: desynapsis_defective def: "Animals exhibit defects in the asymmetric diassembly of the synaptonemal complex during progression through meiosis." [WB:WBPaper00032296, WB:WBPerson712] is_a: WBPhenotype:0000775 ! meiosis_variant [Term] id: WBPhenotype:0001816 name: egg_laying_circuit_variant def: "Neuromuscular signaling between neurons and egg laying musculature varies from that observed for control animals." [WB:WBPaper00032221, WB:WBPerson712] synonym: "egg_laying_circuit_abnormal" NARROW [] is_a: WBPhenotype:0000929 ! hermaphrodite_physiology_variant [Term] id: WBPhenotype:0001817 name: enhanced_taste_aversion_defective def: "The conditioned aversion to a specific chemical compound as a result of that compound being coupled with an unfavorable condition, such as starvation, does not increase to the same extent as observed for control animals." [WB:WBPaper00032335, WB:WBPerson712] synonym: "enhanced_gustatory_plasticity_defective" RELATED [] synonym: "enhanced_taste_aversion_defective" RELATED [] synonym: "starvation_enhanced_taste_aversion_defective" RELATED [] is_a: WBPhenotype:0000147 ! organism_starvation_response_variant is_a: WBPhenotype:0001444 ! aqueous_adaptation_defective [Term] id: WBPhenotype:0001818 name: neuron_activation_variant def: "Activity of the neuron varies from that observed for control animals or neurons. In C. elegans neuron activity is often assayed by observing calcium spikes." [WB:WBPaper00032221, WB:WBPerson712] synonym: "neuron_activation_abnormal" NARROW [] synonym: "neuron_activity_abnormal" RELATED [] is_a: WBPhenotype:0000991 ! neuron_physiology_variant [Term] id: WBPhenotype:0001819 name: pathogen_load_variant def: "The number of pathogens associated with the animal vary from that associated with control animals." [WB:WBPaper00032196, WB:WBPerson712] synonym: "bacterial_load_variant " NARROW [] is_a: WBPhenotype:0001012 ! organism_pathogen_response_variant [Term] id: WBPhenotype:0001820 name: bordering def: "Animals tend to accumulate at the thickest part of the bacterial lawn. " [WB:WBPaper00003187, WB:WBPaper00032342, WB:WBPerson712] synonym: "bordering_increased" RELATED [] is_a: WBPhenotype:0000662 ! foraging_behavior_variant is_a: WBPhenotype:0001291 ! social_behavior_variant [Term] id: WBPhenotype:0001821 name: non_bordering def: "Animals do not accumulate at the thickest part of the bacterial lawn. Animals do not preferentially deplete bacterial food at the thicker parts of the lawn." [WB:WBPaper00032342, WB:WBPerson712] is_a: WBPhenotype:0000662 ! foraging_behavior_variant is_a: WBPhenotype:0001291 ! social_behavior_variant [Term] id: WBPhenotype:0001822 name: dauer_pheromone_secretion_variant def: "Animals produce pheromone but it does not undergo controlled release into the environment. " [WB:WBPaper00032517, WB:WBPerson712] is_a: WBPhenotype:0000258 ! cell_secretion_variant is_a: WBPhenotype:0000609 ! excretory_secretory_system_physiology_variant [Term] id: WBPhenotype:0001823 name: sperm_recruitment_variant def: "Any variation in the mechanism by which sperm find their correct target destinations (spermatheca)." [WB:WBPaper00028527, WB:WBPerson2021] is_a: WBPhenotype:0001424 ! oocyte_physiology_variant [Term] id: WBPhenotype:0001824 name: meiotic_progression_prophase_variant def: "Animals exhibit variations in any process necessary for the progression through prophase during meiosis compared to control animals." [WB:WBPaper00005486, WB:WBPerson557] is_a: WBPhenotype:0000775 ! meiosis_variant [Term] id: WBPhenotype:0001825 name: rudimentary_gonad def: "Animals have very few or no germline nuclei and gonad arms that are very small or missing." [WB:WBPaper00005486, WB:WBPerson557] is_a: WBPhenotype:0001355 ! gonad_morphology_variant [Term] id: WBPhenotype:0001826 name: RNA_degradation_variant def: "Variations in the regulated breakdown of RNA species via the action of cellular enzymes (RNases) compared to control" [WB:WBPaper00032091, WB:WBPerson2021] is_a: WBPhenotype:0000028 ! RNA_processing_variant [Term] id: WBPhenotype:0001827 name: RNA_metabolism_variant def: "Variations in any process that involves the maintenance, biosynthesis or accumulation of RNA in the organism compared to control." [WB:WBPaper00004325, WB:WBPerson2021] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001828 name: RNAi_persistence_variant def: "Variations in the persistence of an RNAi induced phenotype compared to control" [WB:WBPaper00004325, WB:WBPerson2021] is_a: WBPhenotype:0000743 ! RNAi_response_variant [Term] id: WBPhenotype:0001829 name: premature_spermatid_activation def: "Any variation that results in the premature differentiation of spermatids into motile spermatozoa compared to control" [WB:WBPaper00033007, WB:WBPerson2021] is_a: WBPhenotype:0000670 ! spermatogenesis_variant [Term] id: WBPhenotype:0001830 name: response_to_multiple_stressors_variant def: "Any variation in an animal's response to exposure to multiple stressors occuring simultaneously or during an overlapping temporal window compared to control" [WB:WBPaper00031874, WB:WBPerson2021] is_a: WBPhenotype:0000738 ! organism_environmental_stimulus_response_variant [Term] id: WBPhenotype:0001831 name: intestinal_microvilli_variant def: "Any variation in the formation of intestinal microvilli. Microvilli are actin-based cellular structures that form plasma membrane projections into the extracellular space and whose specialized shape provides increased cellular surface area. Microvilli are a crucial component of the terminal differentiation process for many epithelial cell types, usually ones that play an absorptive or filtering role." [WB:WBPaper00025171, WB:WBPerson557] is_a: WBPhenotype:0000705 ! intestinal_cell_development_variant [Term] id: WBPhenotype:0001832 name: nuclear_pore_variant def: "Any variation that disrupts the assembly, distribution, localization or organization of any of the numerous similar discrete openings in the nuclear envelope, where the inner and outer nuclear membranes are joined." [GO:0005643, WB:WBPerson557] is_a: WBPhenotype:0001138 ! nucleus_defective_early_emb [Term] id: WBPhenotype:0001833 name: membrane_trafficking_variant def: "Any variation in the directed movement of substances in a cell, from one side of a membrane to another, compared to control. " [GO:0055085, WB:WBPaper00025137, WB:WBPerson2021] synonym: "membrane_transport_variant" RELATED [] synonym: "transmembrane_transport_variant" RELATED [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0001834 name: mRNA_splicing_variant def: "Variations in the processes regulating the excision of intervening introns from the primary mRNA transcript, compared to control." [GO:0008380, WB:WBPaper00032287, WB:WBPerson2021] is_a: WBPhenotype:0000028 ! RNA_processing_variant [Term] id: WBPhenotype:0001835 name: energy_expenditure_variant def: "Variations in the amount of energy consumed by an organism compared to control. Energy expenditure is often determined by assaying oxygen consumption." [WB:WBPaper00032936, WB:WBPerson2021] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0001836 name: eggshell_morphology_variant def: "Any variation in the overall structure or appearance of the protective barrier which isolates the embryo from the external environment, compared to control ." [WB:WBPaper00033072, WB:WBPerson2021] is_a: WBPhenotype:0000037 ! egg_morphology_variant [Term] id: WBPhenotype:0001837 name: diet_induced_life_span_variant def: "Life span of the animal is not influenced by changes in diet in the same manner as control animals." [WB:WBPaper00032936, WB:WBPerson2021] is_a: WBPhenotype:0000039 ! life_span_variant [Term] id: WBPhenotype:0001838 name: drug_induced_gene_expression_variant def: "Gene expression of an animal is not influenced by drug treatment in the same manner as control animals." [WB:WBPaper00033094, WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene_expression_variant [Term] id: WBPhenotype:0001839 name: phorbol_ester_resistant def: "Animals fail to respond to the concentration of phorbol esters that elicit a response in control animals. Alternatively, animals require increased concentration or longer exposure to this compound to elicit the response compared to control animals. Phorbol esters such as PMA act as DAG mimetics." [WB:WBPaper00033094, WB:WBPerson2021] is_a: WBPhenotype:0000011 ! drug_resistant [Term] id: WBPhenotype:0001840 name: response_to_injury_variant def: "Variations in the processes that restore integrity to a damaged tissue following an injury, compared to control." [GO:0042060, WB:WBPaper00033094, WB:WBPerson2021] synonym: "wound_healing_variant" RELATED [] is_a: WBPhenotype:0000142 ! cell_stress_response_variant [Term] id: WBPhenotype:0001841 name: second_messenger_mediated_signaling_variant def: "Any variation in a series of molecular signals that help relay a receptor mediated signal within the cell, compared to control. Second messengers often comprise of ions (eg: Ca2+) or small molecules (cGMP, cAMP etc) that are formed or released into the cytosol." [GO:0019932, WB:WBPaper00033456, WB:WBPerson2021] is_a: WBPhenotype:0000463 ! metabolic_pathway_variant [Term] id: WBPhenotype:0001842 name: drug_withdrawal_response_variant def: "Any variation in the state or activity of an organism as a result of abrupt discontinuation or decreased dosage of a drug, compared to control." [WB:WBPaper00033168, WB:WBPerson2021] synonym: "rebound response defective" RELATED [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001843 name: hormone_metabolism_variant def: "Animals exhibit variations in any process that involves the degradation, biosynthesis or accumulation of hormones within the organism compared to control. Hormones are naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [GO:0042445, WB:WBPaper00034639, WB:WBPerson2021] is_a: WBPhenotype:0000027 ! organism_metabolism_processing_variant [Term] id: WBPhenotype:0001844 name: lipid_hydrolysis_regulation_variant def: "Variations in the process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids, compared to contro" [GO:0050994, WB:WBPaper00033126, WB:WBPerson2021] synonym: "fat_granule_regulated_breakdown_variant" RELATED [] synonym: "fat_granule_regulated_hydrolysis_variant " RELATED [] synonym: "lipid_lysis_regulation_variant" RELATED [] synonym: "regulation_of_lipid_catabolic_process_variant" RELATED [] is_a: WBPhenotype:0000725 ! lipid_metabolism_variant [Term] id: WBPhenotype:0001845 name: lipid_modification_variant def: "Variations in the covalent alteration of one or more components (eg: fatty acids, sterols etc.) in a lipid, resulting in a change in the properties of the lipid, compared to control." [GO:0030258, WB:WBPaper00034639, WB:WBPerson2021] is_a: WBPhenotype:0000725 ! lipid_metabolism_variant [Term] id: WBPhenotype:0001846 name: phagosome_maturation_defective def: "Early phagosomes fail to undergo the maturation process following the ingestion of particulate material by phagocytosis; During maturation, phagosomes acquire markers of late endosomes and lysosomes." [GO:0001845, WB:WBPaper00031805, WB:WBPerson2021] is_a: WBPhenotype:0000885 ! engulfment_variant [Term] id: WBPhenotype:0001847 name: sterol_induced_dauer_formation_variant def: "Variations in the processes that facilitate/permit dauer entry when exposed to specific sterol molecules, compared to control. " [WB:WBPaper00034639, WB:WBPerson2021] is_a: WBPhenotype:0001539 ! dauer_induction_variant [Term] id: WBPhenotype:0001848 name: tube_morphogenesis_variant def: "Variations in the process by which the anatomical structures of a tube are generated and organized, compared to control. Morphogenesis pertains to the creation of form or shape." [GO:0035239, WB:WBPaper00033081, WB:WBPerson2021] synonym: "tubulogenesis_variant" RELATED [] is_a: WBPhenotype:0000530 ! organ_system_development_variant [Term] id: WBPhenotype:0001849 name: zinc_cellular_homeostasis_variant def: "Variations in the regulation of levels, transport, and metabolism of zinc ions within a cell or between a cell and its external environment, compared to control." [GO:0006882, WB:WBPaper00033166, WB:WBPerson2021] is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001850 name: radiation_induced_germ_cell_apoptosis_resistant def: "Programmed cell death of germ cells caused by exposure to ionizing energy does not occur to the same extent as it does in control animals. " [WB:WBPaper00032006, WB:WBPaper00032243, WB:WBPaper00032356, WB:WBPerson712] is_a: WBPhenotype:0000386 ! genotoxic_induced_apoptosis_variant is_a: WBPhenotype:0000737 ! germ_cell_resistant_ionizing_radiation [Term] id: WBPhenotype:0001851 name: radiation_induced_reproductive_cell_death_variant def: "Animals exhibit variations in radiation induced non-apoptotic death of multipotential precursor cells or tissues (clonogens) compared to control. Elimination of clonogens results in normal tissue damage as well as solid-tumor eradication " [WB:WBPaper00027700, WB:WBPerson2021] is_a: WBPhenotype:0001173 ! non_apoptotic_cell_death_variant is_a: WBPhenotype:0001268 ! induced_cell_death_variant [Term] id: WBPhenotype:0001852 name: antihelmintic_response_variant def: "Animals exhibit variations in their response to an agent that destroys or causes the expulsion of parasitic intestinal worms compared to that observed in control animals." [WB:WBPaper00035074, WB:WBPerson2021] is_a: WBPhenotype:0000459 ! pesticide_response_variant [Term] id: WBPhenotype:0001853 name: AAD_response_variant def: "Animals exhibit variations in their response to the amino-acetonitrile derivatives (AADs) class of synthetic anthelmintics, compared to that observed in control animals." [WB:WBPaper00035150, WB:WBPerson2021] is_a: WBPhenotype:0001852 ! antihelmintic_response_variant [Term] id: WBPhenotype:0001854 name: benomyl_response_variant def: "Animals exhibit variations in their response to the microtubule-depolymerizing drug benomyl, compared to that observed in control animals." [WB:WBPaper00035150, WB:WBPerson2021] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001855 name: fluoride_resistant def: "Animals fail to respond to the concentration of fluoride ions that elicits a response in control animals. Alternatively, animals require increased concentration or longer exposure to fluoride ions to elicit the response compared to control animals." [WB:WBPaper00035174, WB:WBPerson2021] is_a: WBPhenotype:0001502 ! chemical_resistant [Term] id: WBPhenotype:0001856 name: ivermectin_response_variant def: "Animals exhibit variations in their response to ivermectin, an agonist of glutamate-gated chloride channels, compared to that observed in control animals." [WB:WBPaper00035150, WB:WBPaper00035194, WB:WBPerson2021] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001857 name: pathogen_induced_gene_expression_variant def: "Gene expression of an animal is not influenced by the exposure to disease causing agents in the same manner as control animals." [WB:WBPaper00035315, WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene_expression_variant is_a: WBPhenotype:0001012 ! organism_pathogen_response_variant [Term] id: WBPhenotype:0001858 name: suppression_of_head_oscillations_defective def: "Animals fail to suppress head oscillations in response to anterior touch. In C. elegans, this behavior is a result of tyraminergic signaling." [WB:WBPaper00031692, WB:WBPaper00034683, WB:WBPerson2021] synonym: "Sho" RELATED [WB:WBPaper00025096] is_a: WBPhenotype:0000595 ! head_behavior_variant [Term] id: WBPhenotype:0001859 name: Dosage_compensation_complex_assembly_variant def: "Any variation in the aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes, compared to control. " [GO:0042714, WB:WBPaper00035328, WB:WBPerson2021] comment: possible xp synonym: "DCC_localization_variant" RELATED [] is_a: WBPhenotype:0000718 ! dosage_compensation_variant [Term] id: WBPhenotype:0001860 name: endocytic_recycling_defective def: "Variations in the directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport, compared to control." [GO:0032456, WB:WBPaper00035466, WB:WBPerson2021] is_a: WBPhenotype:0001422 ! endocytic_transport_defect [Term] id: WBPhenotype:0001861 name: environmental_stimuli_induced_gene_expression_variant def: "Gene expression of an animal is not influenced by environmental changes in the same manner as control animals." [WB:WBPaper00035435, WB:WBPerson2021] is_a: WBPhenotype:0000717 ! gene_expression_variant [Term] id: WBPhenotype:0001862 name: manganese_cellular_homeostasis_variant def: "Variations in the regulation of levels, transport, and metabolism of manganese ions within a cell or between a cell and its external environment, compared to control. " [GO:0030026, WB:WBPaper00035485, WB:WBPerson2021] comment: possible XP is_a: WBPhenotype:0000585 ! cell_homeostasis_metabolism_variant [Term] id: WBPhenotype:0001863 name: manganese_response_variant def: "Animals exhibit variations in their response to manganese compared to that observed in control animals. " [GO:0010042, WB:WBPaper00035485, WB:WBPerson2021] comment: Possible XP is_a: WBPhenotype:0000591 ! metal_response_variant [Term] id: WBPhenotype:0001864 name: protein_transport_variant def: "Any variation in the processes that modulate the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore compared to control." [GO:0051223, WB:WBPaper00035491, WB:WBPerson2021] comment: Possible XP is_a: WBPhenotype:0001644 ! protein_metabolism_variant [Term] id: WBPhenotype:0001865 name: protein_ubiquitination_variant def: "Variations in the process by which one or more ubiquitin moieties are added to a protein, compared to control. " [GO:0016567, WB:WBPaper00035602, WB:WBPerson2021] comment: Possible XP is_a: WBPhenotype:0001382 ! protein_modification_variant [Term] id: WBPhenotype:0001866 name: reduced_pathogen_accumulation def: "Animals exhibit a reduction in pathogen accumulation, persistent colonization, and luminal distension of the intestine." [GO:0009617, GO:0045087, WB:WBPaper00035215, WB:WBPerson2987] synonym: "Rpa" RELATED [] is_a: WBPhenotype:0001819 ! pathogen_load_variant [Term] id: WBPhenotype:0001867 name: mitotic_spindle_asters_defective_early_emb def: "Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle asters during a mitotic cell cycle." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0001102 ! mitotic_spindle_defective_early_emb is_a: WBPhenotype:0001110 ! aster_defective_early_emb [Term] id: WBPhenotype:0001868 name: meiotic_spindle_defective def: "Cells undergoing meiosis exhibit defects in the overall function or activity of the meiotic spindle." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0000775 ! meiosis_variant [Term] id: WBPhenotype:0001869 name: meiotic_spindle_positioning_defective def: "Cells undergoing meiosis exhibit defects in the positioning of the meiotic spindle." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0001868 ! meiotic_spindle_defective [Term] id: WBPhenotype:0001870 name: meiotic_spindle_rotation_defective def: "Cells undergoing meiosis exhibit defects in the rotation of the meiotic spindle." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0001868 ! meiotic_spindle_defective [Term] id: WBPhenotype:0001871 name: drug_induced_life_span_variant def: "Life span of the animal is not influenced by drug exposure in the same manner as control animals." [WB:WBPaper00035656, WB:WBPerson2021] is_a: WBPhenotype:0000039 ! life_span_variant is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001872 name: drug_induced_locomotion_variant def: "Locomotion of the animal is not influenced by drug exposure in the same manner as control animals." [WB:WBPaper00035656, WB:WBPerson2021] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001873 name: meiotic_spindle_assembly_defective def: "Early embryos exhibit defects in the aggregation, arrangement and bonding together of a set of components to form the meiotic spindle, the array of microtubules and associated molecules that serves to move duplicated and/or homologous chromosomes apart." [WB:WBPaper00032910, WB:WBPerson2987] is_a: WBPhenotype:0001868 ! meiotic_spindle_defective [Term] id: WBPhenotype:0001874 name: protein_neddylation_variant def: "Any variation in the conjugation of the ubiquitin-like protein Nedd8 to another protein compared to control." [GO:0045116, WB:WBPerson2021, WB:WBPerson557] comment: possible XP is_a: WBPhenotype:0001382 ! protein_modification_variant [Term] id: WBPhenotype:0001875 name: anaphase_bridging def: "Chromosomal masses fail to fully separate and remained linked during anaphase." [WB:WBPerson2021, WB:WBPerson557] synonym: "chromosome_bridging" RELATED [] synonym: "lagging_chromatin" RELATED [] is_a: WBPhenotype:0001378 ! mitotic_chromosome_segregation_variant [Term] id: WBPhenotype:0001876 name: centriole_biogenesis_variant def: "Any variation in the formation or disassembly of the cylindrical structures that are composed of groupings of microtubules found close to the nucleus (centrioles) compared to control. Centrioles are arranged perpendicularly and are surrounded by an amorphous mass of dense material (the pericentriolar material). The centrioles and the pericentriolar material constitute the compound structure known as the centrosome." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0001344 ! organelle_organization_biogenesis_variant [Term] id: WBPhenotype:0001877 name: nuclear_membrane_morphology_variant def: "Any variation in the structure, form or composition of the membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated, compared to control." [GO:0005634, WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0001878 name: hydroxyurea_response_variant def: "Animals exhibit variations in the response to the addition of hydroxyurea compared to that observed in control animals. hydroxyurea stops DNA from being replicated." [WB:WBPerson2021, WB:WBPerson557] synonym: "HU_response_variant" RELATED [] synonym: "hydroxycarbamide_response_variant" RELATED [] is_a: WBPhenotype:0000631 ! drug_response_variant [Term] id: WBPhenotype:0001879 name: hydroxyurea_hypersensitive def: "Animals respond to hydroxyurea at a lower concentration or a shorter exposure compared to control animals." [WB:WBPerson2021, WB:WBPerson557] is_a: WBPhenotype:0000010 ! drug_hypersensitive is_a: WBPhenotype:0001878 ! hydroxyurea_response_variant [Term] id: WBPhenotype:0001880 name: endoplasmic_reticulum_morphology_variant def: "Any variation in the form, structure or composition of the endoplasmic reticulum compared to control. The endoplasmic reticulum (ER) is an irregular network of membranes, that occurs in the cytoplasm, and forms a complex meshwork of tubular channels. The ER has two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GO:0005783, WB:WBPaper00025163, WB:WBPerson2987, WB:WBPerson557] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0004001 name: hermaphrodite_mating_variant def: "Any variation in the specific actions or reactions of a hermaphrodite during mating compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "hermaphrodite_mating_abnormal" NARROW [] is_a: WBPhenotype:0000647 ! copulation_variant is_a: WBPhenotype:0000887 ! hermaphrodite_behavior_variant [Term] id: WBPhenotype:0004002 name: attraction_signal_defective def: "Animals exhibit defects in the production of the sensory signal to attract males." [WB:WBPaper00005109, WB:WBPerson557] is_a: WBPhenotype:0004015 ! pre_male_contact_variant [Term] id: WBPhenotype:0004003 name: mate_finding_defective def: "Males exhibit defects in their response to the mate-finding cue." [WB:WBPaper00005109] synonym: "mate_finding_abnormal" NARROW [] synonym: "response_to_male_attractant_abnormal" RELATED [] is_a: WBPhenotype:0004005 ! pre_hermaphrodite_contact_variant [Term] id: WBPhenotype:0004004 name: male_response_to_contact_defective def: "The inability of a male to respond properly to a potential mate after contact. In C.elegans, proper response includes apposing the ventral side of his tail to the hermaphrodite's body and swimming backward." [GO:0034606, WB:WBPaper00000392, WB:WBPaper00002109, WB:WBPerson557] is_a: WBPhenotype:0001414 ! male_mating_defective is_a: WBPhenotype:0004006 ! post_hermaphrodite_contact_variant [Term] id: WBPhenotype:0004005 name: pre_hermaphrodite_contact_variant def: "Males exhibit variations in mating behavior prior to contacting its mate compared to control." [WB:WBPerson557] synonym: "pre_hermaphrodite_contact_abnormal" NARROW [] is_a: WBPhenotype:0000648 ! male_mating_variant [Term] id: WBPhenotype:0004006 name: post_hermaphrodite_contact_variant def: "Males exhibit variations in mating behavior after contacting its mate compared to control." [WB:WBPerson557] synonym: "post_hermaphrodite_contact_abnormal" NARROW [] is_a: WBPhenotype:0000648 ! male_mating_variant [Term] id: WBPhenotype:0004007 name: periodic_spicule_prodding_defective def: "Males exhibit defects in the continuous prodding of spicule tips at the vulva prior to prolonged spicule insertion." [GO:0034609, WB:WBPerson2021, WB:WBPerson557] synonym: "spicule_prodding_defective" RELATED [] is_a: WBPhenotype:0000279 ! spicule_insertion_defective [Term] id: WBPhenotype:0004008 name: sustained_spicule_protraction_defective def: "Males exhibit defects in the prolonged, tonic, spicule extrusion through the vulva prior to sperm transfer." [GO:0034609, WB:WBPerson2021, WB:WBPerson557] synonym: "prolonged_spicule_protraction_defective" RELATED [] is_a: WBPhenotype:0000279 ! spicule_insertion_defective [Term] id: WBPhenotype:0004009 name: approximate_vulval_location_variant def: "Any variation in the mating process that includes the male stopping at the vulva (usually after backing) compared to control. In C. elegans general vulva location (stopping) requires the hook sensillum." [WB:WBPaper00002109, WB:WBPerson2021, WB:WBPerson557] synonym: "approximate_vulval_location_abnormal" NARROW [] synonym: "general_vulval_location_abnormal" RELATED [] is_a: WBPhenotype:0000649 ! vulva_location_variant [Term] id: WBPhenotype:0004010 name: precise_vulval_location_variant def: "Any variation in the mating process that includes the male positioning his tail precisely over the vulva so that he may insert his spicules and ejaculate compared to control. In C. elegans precise vulva location (coordinating movement and tail positioning) requires the post cloacal sensillium and the spicules." [WB:WBPaper00002109, WB:WBPerson2021, WB:WBPerson557] synonym: "precise_vulval_location_abnormal" NARROW [] is_a: WBPhenotype:0000649 ! vulva_location_variant [Term] id: WBPhenotype:0004011 name: sperm_transfer_cessation_defective def: "Any variation in the retraction of spicules after all sperm that exit the seminal vesicle have been released compared to control." [WB:WBPaper00028400] is_a: WBPhenotype:0000284 ! sperm_transfer_defective [Term] id: WBPhenotype:0004012 name: sperm_transfer_continuation_defective def: "Any variation in the continued movement of sperm through the vas deferens, exiting the cloaca, compared to control. In C. elegans, when all sperm that exit the seminal vesicle have been released, the spicules retract into the male." [WB:WBPaper00028400] is_a: WBPhenotype:0000284 ! sperm_transfer_defective [Term] id: WBPhenotype:0004013 name: sperm_release_defective def: "Any variation in the initial movement of sperm through the vas deferens, exiting the cloaca, compared to control." [WB:WBPaper00028400] is_a: WBPhenotype:0000284 ! sperm_transfer_defective [Term] id: WBPhenotype:0004014 name: post_male_contact_variant def: "Any variation in the specific actions or reactions of a hermaphrodite after male contact during mating compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "post_male_contact_abnormal" NARROW [] is_a: WBPhenotype:0004001 ! hermaphrodite_mating_variant [Term] id: WBPhenotype:0004015 name: pre_male_contact_variant def: "Any variation in the specific actions or reactions of a hermaphrodite prior to male contact during mating compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "pre_male_contact_abnormal" NARROW [] is_a: WBPhenotype:0004001 ! hermaphrodite_mating_variant [Term] id: WBPhenotype:0004016 name: dauer_nictation_behavior_variant def: "Any variation in the behavior exhibited by dauer larva in which they crawl up upon the substrate and wave back and forth while standing on their tail compared to control. Nictation is often associated with the search for a new host." [WB:WBPaper00027241, WB:WBPerson2021, WB:WBPerson557] synonym: "dauer_nictation_behavior_abnormal" NARROW [] is_a: WBPhenotype:0001001 ! dauer_behavior_variant [Term] id: WBPhenotype:0004017 name: locomotor_coordination_variant def: "Animals exhibit variations in their ability to maintain characteristic and effective locomotion compared to control." [WB:WBperson557] synonym: "locomotor_coordination_abnormal" NARROW [] is_a: WBPhenotype:0000643 ! locomotion_variant [Term] id: WBPhenotype:0004018 name: sinusoidal_movement_variant def: "Any variation in the propagation of the contraction sine wave along the body while an animal travels from one location to another, compared to control. " [WB:WBPerson2021, WB:WBPerson557] synonym: "sinusoidal_movement_abnormal" NARROW [] is_a: WBPhenotype:0004017 ! locomotor_coordination_variant [Term] id: WBPhenotype:0004022 name: amplitude_of_movement_variant def: "Any variation in the extent of a vibratory movement (as a worm bend) measured from the mean position to an extreme position compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "amplitude_of_movement_abnormal" NARROW [] relationship: part_of WBPhenotype:0004018 ! sinusoidal_movement_variant [Term] id: WBPhenotype:0004023 name: frequency_of_body_bend_variant def: "Animals exhibit variations in the frequency of oscillations between adjacent body segments from that observed for control animals." [WB:WBPaper00024949, WB:WBPerson557, WB:WBPerson712] synonym: "bending_frequency_abnormal" RELATED [] synonym: "frequency_of_body_bend_abnormal" NARROW [] is_a: WBPhenotype:0001703 ! body_bend_variant [Term] id: WBPhenotype:0004024 name: wavelength_of_movement_variant def: "Any variation in the distance in the line of advance of a body wave from any one point to the next point of corresponding phase compared to control." [WB:WBPerson2021, WB:WBPerson557] synonym: "wavelength_of_movement_abnormal" NARROW [] relationship: part_of WBPhenotype:0004018 ! sinusoidal_movement_variant [Term] id: WBPhenotype:0004025 name: velocity_of_movement_variant def: "Animals exhibit variations in the net velocity of an animal, that is, the maximum distance an animal traverses over an extended period of time, from that observed for control animals." [WB:WBPaper00032008, WB:WBPerson712] synonym: "velocity_of_movement_abnormal" NARROW [] relationship: part_of WBPhenotype:0004018 ! sinusoidal_movement_variant [Term] id: WBPhenotype:0004026 name: nose_touch_variant def: "Variations in the ability of an animal to respond with characteristic backward movement after a nose-on collision with an object compared to control. In C. elegans, this phenotype is usually assayed via stroking with a hair or similar fiber on the anterior most tip of the animal." [WB:WBPaper00001705, WB:WBPerson557] synonym: "nose_touch_abnormal" NARROW [] is_a: WBPhenotype:0000315 ! mechanosensation_variant [Term] id: WBPhenotype:0004027 name: plate_tap_reflex_variant def: "Animals exhibit variations in their response to substrate vibration compared to control." [WB:WBPerson557] synonym: "plate_tap_reflex_abnormal" NARROW [] is_a: WBPhenotype:0000315 ! mechanosensation_variant [Term] id: WBPhenotype:0004028 name: slowing_response_on_food_variant def: "Animals exhibit variations in modulating their locomotory rate in response to its food , compared to control. Basal slowing response refers to when well-fed animals move more slowly in the presence of bacteria than in the absence of bacteria . Second , food-deprived wild-type animals , when transferred to bacteria , display a dramatically enhanced slowing response that ensures that the animals do not leave their newly encountered source of food." [WB:WBPaper00004195, WB:WBPerson2021] synonym: "slowing_response_on_food_abnormal" NARROW [] is_a: WBPhenotype:0000315 ! mechanosensation_variant [Term] id: WBPhenotype:0004029 name: sexually_dimorphic_mechanosensation_variant def: "Any variation with respect to perception or response to mechanical stimuli in a sex dependent manner compared to control animals." [WB:WBPerson2021, WB:WBPerson557] synonym: "sexually_dimorphic_mechanosensation_abnormal" NARROW [] is_a: WBPhenotype:0000315 ! mechanosensation_variant [Term] id: WBPhenotype:0004030 name: male_response_to_hermaphrodite_variant def: "Any variation in the response by the male to a hermaphrodite after initial contact following mate finding compared to control. In C. elegans the male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [GO:0034606, WB:WBPaper00002109, WB:WBPerson2021, WB:WBPerson557] synonym: "male_response_to_hermaphrodite_abnormal" NARROW [] is_a: WBPhenotype:0004029 ! sexually_dimorphic_mechanosensation_variant [Term] id: WBPhenotype:0004031 name: mate_searching_variant def: "Any variation in the ability of an animal to search for a mate compared to control. In C. elegans, this is defined by failure of the leaving assay" [WB:WBPaper00024428] synonym: "mate_searching_abnormal" NARROW [] is_a: WBPhenotype:0004005 ! pre_hermaphrodite_contact_variant [Term] id: WBPhenotype:0006001 name: squashed_vulva def: "The apparent partial collapse of the vulval invagination and the elongation of central vulva cells often leading to a flattened appearance." [WB:WBPaper00003405] is_a: WBPhenotype:0000510 ! vulval_invagination_variant_L4 [Term] id: WBPhenotype:0008001 name: embryonic_cell_fate_specification_variant def: "Any variation in the processes that govern acquisition of particular cell fates in the embryo, from the time of zygote formation until hatching compared to control." [WB:kmva] synonym: "embryonic_cell_fate_specification_abnormal" NARROW [] is_a: WBPhenotype:0000216 ! cell_fate_specification_variant is_a: WBPhenotype:0000749 ! embryonic_development_variant [Term] id: WBPhenotype:0008002 name: embryonic_somatic_cell_fate_specification_variant def: "Any variation in the processes that govern acquisition of somatic cell fates in the embryo, from the time of zygote formation until hatching compared to control." [WB:kmva] synonym: "embryonic_somatic_cell_fate_specification_abnormal" NARROW [] is_a: WBPhenotype:0008001 ! embryonic_cell_fate_specification_variant [Term] id: WBPhenotype:0008003 name: odorant_imprinting_variant def: "Any variation in a learned olfactory response whereby exposure of animals to odorants during specific developmental times or physiological states results in a lasting memory compared to control. In control animals, this imprinting determines the animal's behavior upon encountering the same odorant at a later time." [WB:WBPaper00026662, WB:WBPerson1843] synonym: "odorant_imprinting_abnormal" NARROW [] synonym: "olfactory_imprinting_abnormal" EXACT [] is_a: WBPhenotype:0001048 ! odorant_chemosensory_response_variant [Term] id: WBPhenotype:0010001 name: cell_growth_variant def: "Variations in the process(es) by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter compared to control." [GO:0016049, WB:rk] subset: phenotype_slim_wb synonym: "cell_growth_abnormal" NARROW [] is_a: WBPhenotype:0000536 ! cell_physiology_variant [Term] id: WBPhenotype:0010002 name: cell_organization_biogenesis_variant def: "Variations in the process(es) involved in the assembly and arrangement of cell structures compared to control." [GO:0016043, WB:rk] subset: phenotype_slim_wb synonym: "cell_organization_biogenesis_abnormal" NARROW [] is_a: WBPhenotype:0000533 ! cell_morphology_variant [Term] id: WBPhenotype:0010003 name: cell_corpse_appearance_delayed def: "Animals exhibit a decreased rate programmed cell death pathway leading to the destruction of the cell, viewable in its terminally dismanteled form of a cell corpse, compared to that observed for control cells." [WB:rk, WB:WBPerson712] is_a: WBPhenotype:0000185 ! apoptosis_protracted [Term] id: WBPhenotype:0010004 name: cell_corpse_degradation_variant def: "Variations in the process(es) that constitute cell corpse degradation within the engulfing cell compared to control." [WB:rk] synonym: "cell_corpse_degradation_abnormal" NARROW [] xref: WB:rk is_a: WBPhenotype:0000730 ! apoptosis_variant [Typedef] id: part_of name: part_of subset: phenotype_slim_wb is_transitive: true