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experimental_condition_ontology
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jrsmith
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experimental_condition_ontology
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JSmith
2014-03-07T11:32:23Z
BFO:0000051
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CHEBI:35679
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CHEBI:4495
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MESH:D002976
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MESH:D003000
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MESH:D015737
A state of being, an external or environmental factor or a treatment observed or administered prior to or concurrent with an investigative procedure such as an assessment of a morphological or physiological state or property in a single individual or sample or in a group of individuals or samples, especially a state, factor or treatment which has the potential to influence the outcome of such an assessment.
experimental_condition_ontology
XCO:0000000
experimental condition
XCO:0000000
A state of being, an external or environmental factor or a treatment observed or administered prior to or concurrent with an investigative procedure such as an assessment of a morphological or physiological state or property in a single individual or sample or in a group of individuals or samples, especially a state, factor or treatment which has the potential to influence the outcome of such an assessment.
PMID:22654893
http://www.thefreedictionary.com/
The state of being involved in some action, either physical or mental.
experimental_condition_ontology
XCO:0000001
activity
XCO:0000001
The state of being involved in some action, either physical or mental.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A state in which the organism is not exhibiting any physical exertion.
experimental_condition_ontology
XCO:0000002
resting
XCO:0000002
A state in which the organism is not exhibiting any physical exertion.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A state in which the organism is on an non-operating exercise machine in which there is an endless belt that moves when operational so that the organism can walk or run in place.
experimental_condition_ontology
XCO:0000003
resting on treadmill
XCO:0000003
A state in which the organism is on an non-operating exercise machine in which there is an endless belt that moves when operational so that the organism can walk or run in place.
Encarta:Encarta_World_English_Dictionary
The action of ambulation on an exercise apparatus with an endless moving belt on which the organism can walk in place.
experimental_condition_ontology
XCO:0000004
walking on treadmill
XCO:0000004
The action of ambulation on an exercise apparatus with an endless moving belt on which the organism can walk in place.
Encarta:Encarta_World_English_Dictionary
The act of rapidly moving the feet on an exercise apparatus with an endless belt that allows the user to perform the action of running in place.
experimental_condition_ontology
XCO:0000005
running on treadmill
XCO:0000005
The act of rapidly moving the feet on an exercise apparatus with an endless belt that allows the user to perform the action of running in place.
Encarta:Encarta_World_English_Dictionary
This is any condition in which the main influencing factor is swimming, the action of a subject moving it's appendages to propel itself through water.
experimental_condition_ontology
XCO:0000006
swimming
XCO:0000006
This is any condition in which the main influencing factor is swimming, the action of a subject moving it's appendages to propel itself through water.
Encarta:Encarta_World_English_Dictionary
This is any condition in which the main influencing factor is walking, the act of ambulation, moving oneself forward on legs or on an exercise apparatus.
experimental_condition_ontology
XCO:0000007
walking
XCO:0000007
This is any condition in which the main influencing factor is walking, the act of ambulation, moving oneself forward on legs or on an exercise apparatus.
Encarta:Encarta_World_English_Dictionary
This is any condition in which the main influencing factor is running, the action of rapid movement of feet that propels the organism forward or is done on an exercise machine so that the organism performs the activity in place.
experimental_condition_ontology
XCO:0000008
running
XCO:0000008
This is any condition in which the main influencing factor is running, the action of rapid movement of feet that propels the organism forward or is done on an exercise machine so that the organism performs the activity in place.
Encarta:Encarta_World_English_Dictionary
An experimental condition in which the amount of one or more of the gases which make up the air surrounding an organism are controlled, or in which additional components are added to the air surrounding an organism, as part of the experiment on that organism.
experimental_condition_ontology
XCO:0000009
controlled atmosphere composition
XCO:0000009
An experimental condition in which the amount of one or more of the gases which make up the air surrounding an organism are controlled, or in which additional components are added to the air surrounding an organism, as part of the experiment on that organism.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
RGD:MS
A condition in which the oxygen level of the air surrounding an organism or breathed by the organism is controlled as part of the experiment.
experimental_condition_ontology
XCO:0000010
controlled air oxygen content
XCO:0000010
A condition in which the oxygen level of the air surrounding an organism or breathed by the organism is controlled as part of the experiment.
RGD:MS
The degree of heat or cold of the air surrounding an organism.
experimental_condition_ontology
XCO:0000011
air temperature
XCO:0000011
The degree of heat or cold of the air surrounding an organism.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the level of carbon dioxide in the air surrounding the organism or breathed by the organism is controlled as part of the experiment.
experimental_condition_ontology
XCO:0000012
air carbon dioxide content
XCO:0000012
A condition in which the level of carbon dioxide in the air surrounding the organism or breathed by the organism is controlled as part of the experiment.
RGD:MS
The food and drink consumed by an organism day to day.
experimental_condition_ontology
XCO:0000013
diet
XCO:0000013
The food and drink consumed by an organism day to day.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A regimen of solid food in which the amount of one or more elements of the diet are controlled.
experimental_condition_ontology
XCO:0000014
controlled content diet
XCO:0000014
A regimen of solid food in which the amount of one or more elements of the diet are controlled.
RGD:MS
A regimen of solid food in which the number of calories consumed is controlled.
experimental_condition_ontology
XCO:0000015
controlled calorie content diet
XCO:0000015
A regimen of solid food in which the number of calories consumed is controlled.
RGD:MS
This is any condition in which the main influencing factor is standard rat chow, a laboratory foodstuff which typically has 380-390 kcal/100 g with 9-10% of calories derived from fat, 70-80% of calories derived from carbohydrate, and 10-15% of calories derived from protein.
standard rodent chow
experimental_condition_ontology
XCO:0000016
standard rat chow
XCO:0000016
This is any condition in which the main influencing factor is standard rat chow, a laboratory foodstuff which typically has 380-390 kcal/100 g with 9-10% of calories derived from fat, 70-80% of calories derived from carbohydrate, and 10-15% of calories derived from protein.
PMID:36386439
https://www.zeiglerfeed.com/research-diets/rodent-nih-31-open-formula-auto/
Surgical removal of kidney.
mshimoyama
2011-11-02T02:06:00Z
experimental_condition_ontology
XCO:0000017
nephrectomy
XCO:0000017
Surgical removal of kidney.
RGD:MS
Surgical removal of both kidneys.
mshimoyama
2011-11-02T02:07:13Z
experimental_condition_ontology
XCO:0000018
bilateral nephrectomy
XCO:0000018
Surgical removal of both kidneys.
RGD:MS
The solid food that is consumed by an organism.
experimental_condition_ontology
XCO:0000019
solid diet
XCO:0000019
The solid food that is consumed by an organism.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A liquid consumed by an organism.
experimental_condition_ontology
XCO:0000020
drink
XCO:0000020
A liquid consumed by an organism.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
This is any condition in which the main influencing factor is water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Water may be used for drinking, as a solvent, or as an environmental component.
H2O
experimental_condition_ontology
XCO:0000021
water
XCO:0000021
This is any condition in which the main influencing factor is water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Water may be used for drinking, as a solvent, or as an environmental component.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://www.yourdictionary.com/drink
A regimen of solid food in which the amount of sodium consumed is controlled.
experimental_condition_ontology
XCO:0000022
controlled sodium content diet
XCO:0000022
A regimen of solid food in which the amount of sodium consumed is controlled.
RGD:MS
A drink made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, for consumption by an organism in an experiment.
experimental_condition_ontology
XCO:0000023
controlled ethanol content drinking water
XCO:0000023
A drink made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, for consumption by an organism in an experiment.
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A regimen of solid food in which the amount of iron consumed is controlled.
controlled Fe content diet
experimental_condition_ontology
XCO:0000024
controlled iron content diet
XCO:0000024
A regimen of solid food in which the amount of iron consumed is controlled.
ISBN-13:9780781733908
https://www.merriam-webster.com
A regimen of solid food in which the amount of fat consumed is controlled.
experimental_condition_ontology
XCO:0000025
controlled fat content diet
XCO:0000025
A regimen of solid food in which the amount of fat consumed is controlled.
RGD:MS
The process of ablating or extracting all or part of an organ, gland or other body part from an organism as a medical or experimental procedure.
experimental_condition_ontology
XCO:0000026
surgical removal
XCO:0000026
The process of ablating or extracting all or part of an organ, gland or other body part from an organism as a medical or experimental procedure.
http://www.thefreedictionary.com/
Any insertion of a tissue, material or device into the body using a procedure involving incision into the body.
experimental_condition_ontology
XCO:0000027
surgical implantation
XCO:0000027
Any insertion of a tissue, material or device into the body using a procedure involving incision into the body.
Collins:Collins_Online_English_Dictionary
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A drink containing caffeine, one of the methylxanthines soluble in water and alcohol and obtainable from coffee, tea, guarana and mate.
experimental_condition_ontology
XCO:0000028
caffeinated drink
XCO:0000028
A drink containing caffeine, one of the methylxanthines soluble in water and alcohol and obtainable from coffee, tea, guarana and mate.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A regimen of solid food in which the amount of carbohydrates consumed is controlled.
experimental_condition_ontology
XCO:0000029
controlled carbohydrate content diet
XCO:0000029
A regimen of solid food in which the amount of carbohydrates consumed is controlled.
RGD:MS
A regimen of solid food in which the amount of protein consumed is controlled.
experimental_condition_ontology
XCO:0000030
controlled protein content diet
XCO:0000030
A regimen of solid food in which the amount of protein consumed is controlled.
RGD:MS
A regimen of solid food in which the amount of calcium consumed is controlled.
experimental_condition_ontology
XCO:0000031
controlled calcium content diet
XCO:0000031
A regimen of solid food in which the amount of calcium consumed is controlled.
RGD:MS
A regimen of solid food in which the amount of potassium consumed is controlled.
experimental_condition_ontology
XCO:0000032
controlled potassium content diet
XCO:0000032
A regimen of solid food in which the amount of potassium consumed is controlled.
RGD:MS
experimental_condition_ontology
XCO:0000033
housing condition
XCO:0000033
experimental_condition_ontology
XCO:0000034
individual housing
XCO:0000034
experimental_condition_ontology
XCO:0000035
housing in pairs
XCO:0000035
experimental_condition_ontology
XCO:0000036
housing with socially dominant partner
XCO:0000036
experimental_condition_ontology
XCO:0000037
housing with socially subordinate partner
XCO:0000037
The condition of being subjected to any type of energy transmitted by waves through space or through some medium or to a stream of particles, such as electrons or alpha particles.
experimental_condition_ontology
XCO:0000038
radiation exposure
XCO:0000038
The condition of being subjected to any type of energy transmitted by waves through space or through some medium or to a stream of particles, such as electrons or alpha particles.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
The condition of being subjected to transmitted energy composed of particles that individually carry enough kinetic energy to liberate an electron from an atom or molecule.
experimental_condition_ontology
XCO:0000039
ionizing radiation exposure
XCO:0000039
The condition of being subjected to transmitted energy composed of particles that individually carry enough kinetic energy to liberate an electron from an atom or molecule.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Ionizing_radiation
The condition of being subjected to high frequency, high energy electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components. Gamma radiation is traditionally considered to have wavelengths less than 0.01 nm and are generally emitted by nuclei rather than by electrons.
gamma radiation exposure
experimental_condition_ontology
XCO:0000040
gamma ray exposure
XCO:0000040
The condition of being subjected to high frequency, high energy electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components. Gamma radiation is traditionally considered to have wavelengths less than 0.01 nm and are generally emitted by nuclei rather than by electrons.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Gamma_ray
The condition of being subjected to transmitted energy from the gaseous radioactive element radon, atomic number 86, resulting from decay of radium. Such radiation is composed of particles that individually carry enough kinetic energy to liberate an electron from an atom or molecule. alpha, beta, and gamma rays are released during the radioactive decay of radon.
experimental_condition_ontology
XCO:0000041
radon exposure
XCO:0000041
The condition of being subjected to transmitted energy from the gaseous radioactive element radon, atomic number 86, resulting from decay of radium. Such radiation is composed of particles that individually carry enough kinetic energy to liberate an electron from an atom or molecule. alpha, beta, and gamma rays are released during the radioactive decay of radon.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Ionizing_radiation
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, in the part of the electromagnetic spectrum with wavelengths between about 10 and 400 nm. Ultraviolet radiation can be ionizing or non-ionizing depending on the wavelength.
UV radiation exposure
experimental_condition_ontology
XCO:0000042
ultraviolet ray exposure
XCO:0000042
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, in the part of the electromagnetic spectrum with wavelengths between about 10 and 400 nm. Ultraviolet radiation can be ionizing or non-ionizing depending on the wavelength.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Electromagnetic_Radiation
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between approximately 0.01 and 10 nm.
X-radiation exposure
roentgen radiation exposure
experimental_condition_ontology
XCO:0000043
X-ray exposure
XCO:0000043
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between approximately 0.01 and 10 nm.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
http://en.wikipedia.org/wiki/Electromagnetic_Radiation
The condition of being subjected to transmitted energy that does not carry enough energy per quantum to completely remove an electron from an atom or molecule. Such radiation has sufficient energy only for excitation, the movement of an electron to a higher energy state.
experimental_condition_ontology
XCO:0000044
non-ionizing radiation exposure
XCO:0000044
The condition of being subjected to transmitted energy that does not carry enough energy per quantum to completely remove an electron from an atom or molecule. Such radiation has sufficient energy only for excitation, the movement of an electron to a higher energy state.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Non-ionizing_radiation
The condition of being subjected to energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components. Electromagnetic radiation includes, in order of decreasing wavelength, radio waves, microwaves, infrared, visible, and ultraviolet light, x-rays, gamma rays, and cosmic rays.
experimental_condition_ontology
XCO:0000045
electromagnetic radiation exposure
XCO:0000045
The condition of being subjected to energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components. Electromagnetic radiation includes, in order of decreasing wavelength, radio waves, microwaves, infrared, visible, and ultraviolet light, x-rays, gamma rays, and cosmic rays.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Electromagnetic_Radiation
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths longer than those of visible light, i.e. from approximately 750 nm to 1 mm.
IR radiation exposure
experimental_condition_ontology
XCO:0000046
infrared radiation exposure
XCO:0000046
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths longer than those of visible light, i.e. from approximately 750 nm to 1 mm.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
http://en.wikipedia.org/wiki/Electromagnetic_Radiation
An action or condition designed to cause the registration or perception of a stimulus and the voyage made by incoming nerve impulses from the sense organs to the nerve centers. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
experimental_condition_ontology
XCO:0000047
sensory stimulus
XCO:0000047
An action or condition designed to cause the registration or perception of a stimulus and the voyage made by incoming nerve impulses from the sense organs to the nerve centers. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://www.medterms.com
Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of hearing. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
audible sound stimulus
experimental_condition_ontology
XCO:0000048
auditory stimulus
XCO:0000048
Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of hearing. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any action or condition designed to cause the registration or perception of a stimulus by the optical sense organs. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
experimental_condition_ontology
XCO:0000049
visual stimulus
XCO:0000049
Any action or condition designed to cause the registration or perception of a stimulus by the optical sense organs. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any action or condition designed to cause the registration or perception of a stimulus, by organs or receptors involved in the sense of smell. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
experimental_condition_ontology
XCO:0000050
olfactory stimulus
XCO:0000050
Any action or condition designed to cause the registration or perception of a stimulus, by organs or receptors involved in the sense of smell. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any action or condition designed to cause the registration or perception of a stimulus by the gustatory receptors in the tongue. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
experimental_condition_ontology
XCO:0000051
taste stimulus
XCO:0000051
Any action or condition designed to cause the registration or perception of a stimulus by the gustatory receptors in the tongue. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of touch, that is, the physiological sense by which external objects or forces are perceived through contact with the body. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
experimental_condition_ontology
XCO:0000052
tactile stimulus
XCO:0000052
Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of touch, that is, the physiological sense by which external objects or forces are perceived through contact with the body. A stimulus is anything that excites or incites an organism or part thereof to function, become active, or respond.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
An activity or condition involving a high temperature directed toward a particular part of an organism's body.
heat exposure, targeted
experimental_condition_ontology
XCO:0000053
targeted heat exposure
XCO:0000053
An activity or condition involving a high temperature directed toward a particular part of an organism's body.
Collins:Collins_Online_English_Dictionary
An activity or condition involving a low temperature directed toward a particular part of an organism's body.
cold exposure, targeted
experimental_condition_ontology
XCO:0000054
targeted cold exposure
XCO:0000054
An activity or condition involving a low temperature directed toward a particular part of an organism's body.
Collins:Collins_Online_English_Dictionary
This is any condition in which the main influencing factor is the stimulation of nerves involved in the physiological sense by which external objects or forces are perceived through contact with the body via application of an electric current.
experimental_condition_ontology
foot shock
XCO:0000055
tactile electric shock exposure
XCO:0000055
This is any condition in which the main influencing factor is the stimulation of nerves involved in the physiological sense by which external objects or forces are perceived through contact with the body via application of an electric current.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A baseline condition in which none of the experimental manipulations are performed.
experimental_condition_ontology
standard control condition
XCO:0000056
naive control condition
true
XCO:0000056
A baseline condition in which none of the experimental manipulations are performed.
RGD:MS
Breathing in again air which has been exhaled.
mshimoyama
2009-12-17T01:47:13Z
experimental_condition_ontology
XCO:0000057
rebreathed air
XCO:0000057
Breathing in again air which has been exhaled.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
The temperature of the air surrounding an organism which is considered the most common level for the facility. For humans the temperature considered most comfortable for a room is between 18 and 27 degrees celsius.
mshimoyama
2009-12-17T01:49:34Z
experimental_condition_ontology
XCO:0000058
room temperature
XCO:0000058
The temperature of the air surrounding an organism which is considered the most common level for the facility. For humans the temperature considered most comfortable for a room is between 18 and 27 degrees celsius.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Action in which a part of the body or whole body is involved in movement.
mshimoyama
2009-12-17T01:50:15Z
experimental_condition_ontology
XCO:0000059
physical activity
XCO:0000059
Action in which a part of the body or whole body is involved in movement.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Being in a state of action within the mind often involving manipulation of words or numbers.
mshimoyama
2009-12-17T01:50:54Z
experimental_condition_ontology
XCO:0000060
mental activity
XCO:0000060
Being in a state of action within the mind often involving manipulation of words or numbers.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
An activity in which a person starts with a number and deducts a specified number from that and then deducts the same number from the remainder of the first computation, without using a calculator or pencil and paper.
mshimoyama
2009-12-17T01:51:15Z
experimental_condition_ontology
XCO:0000061
serial subtraction exercise
XCO:0000061
An activity in which a person starts with a number and deducts a specified number from that and then deducts the same number from the remainder of the first computation, without using a calculator or pencil and paper.
Encarta:Encarta_World_English_Dictionary
The action of riding on a stationary or moving vehicle with wheels that is propelled by the movement of a person's legs.
mshimoyama
2009-12-17T01:51:51Z
experimental_condition_ontology
XCO:0000062
cycling
XCO:0000062
The action of riding on a stationary or moving vehicle with wheels that is propelled by the movement of a person's legs.
RGD:MS
The act of propelling the wheel or wheels of a fixed exercise machine through the action of one's legs.
mshimoyama
2009-12-17T01:52:04Z
experimental_condition_ontology
XCO:0000063
cycling, stationary
XCO:0000063
The act of propelling the wheel or wheels of a fixed exercise machine through the action of one's legs.
RGD:MS
The action of propelling a two wheeled vehicle by the movement of a person's legs.
mshimoyama
2009-12-17T01:52:17Z
experimental_condition_ontology
XCO:0000064
cycling, non-stationary
XCO:0000064
The action of propelling a two wheeled vehicle by the movement of a person's legs.
Encarta:Encarta_World_English_Dictionary
The action of squeezing an apparatus that measures the muscular contraction of the hand, used as a condition of exertion in experiments measuring other physiological functions.
mshimoyama
2009-12-17T01:52:57Z
experimental_condition_ontology
XCO:0000065
hand dynamometer activity
XCO:0000065
The action of squeezing an apparatus that measures the muscular contraction of the hand, used as a condition of exertion in experiments measuring other physiological functions.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Change in position or attitude of body as part of the experiment in which measurements are taken before, during and/or after the change.
mshimoyama
2009-12-17T01:53:24Z
experimental_condition_ontology
XCO:0000066
body position change
XCO:0000066
Change in position or attitude of body as part of the experiment in which measurements are taken before, during and/or after the change.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
mshimoyama
2009-12-17T01:53:35Z
experimental_condition_ontology
XCO:0000067
body position change, seated to standing
XCO:0000067
mshimoyama
2009-12-17T01:53:58Z
experimental_condition_ontology
XCO:0000068
body position change, supine to standing
XCO:0000068
mshimoyama
2009-12-17T01:56:44Z
experimental_condition_ontology
XCO:0000069
standard diet
XCO:0000069
A drink containing ethanol, a transparent, colorless, volatile,flammable liquid, which is formed by microbial fermentation of carbohydrates.
mshimoyama
2010-01-05T03:10:55Z
experimental_condition_ontology
ethanol
XCO:0000070
alcoholic drink
XCO:0000070
A drink containing ethanol, a transparent, colorless, volatile,flammable liquid, which is formed by microbial fermentation of carbohydrates.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
An alcoholic drink brewed by fermenting malt with sugar and yeast and flavored with hops.
mshimoyama
2010-01-05T03:11:11Z
experimental_condition_ontology
XCO:0000071
beer
XCO:0000071
An alcoholic drink brewed by fermenting malt with sugar and yeast and flavored with hops.
Encarta:Encarta_World_English_Dictionary
Alcoholic drink made by fermenting the juice of grapes.
mshimoyama
2010-01-05T03:11:23Z
experimental_condition_ontology
XCO:0000072
wine
XCO:0000072
Alcoholic drink made by fermenting the juice of grapes.
Encarta:Encarta_World_English_Dictionary
Alcoholic beverage produced by distillation.
mshimoyama
2010-01-05T03:11:33Z
experimental_condition_ontology
XCO:0000073
liquor
XCO:0000073
Alcoholic beverage produced by distillation.
Encarta:Encarta_World_English_Dictionary
A drink made up of water and a specified amount of caffeine consumed by an organism as part of an experiment. Caffeine is a xanthine alkaloid that acts primarily as a central nervous system and metabolic stimulant, and also as a mild vasoconstrictor, diuretic, and bronchodilator.
mshimoyama
2010-01-05T03:15:30Z
experimental_condition_ontology
XCO:0000074
controlled caffeine content drinking water
XCO:0000074
A drink made up of water and a specified amount of caffeine consumed by an organism as part of an experiment. Caffeine is a xanthine alkaloid that acts primarily as a central nervous system and metabolic stimulant, and also as a mild vasoconstrictor, diuretic, and bronchodilator.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Caffeine
mshimoyama
2010-01-05T03:15:42Z
experimental_condition_ontology
XCO:0000075
tea
XCO:0000075
A drink made of the decoction or infusion of the dried, roasted sees of Coffea arabica or Coffea canephora.
mshimoyama
2010-01-05T03:15:55Z
experimental_condition_ontology
XCO:0000076
coffee
XCO:0000076
A drink made of the decoction or infusion of the dried, roasted sees of Coffea arabica or Coffea canephora.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
The use of any product made for human consumption from Nicotiana tabacum.
mshimoyama
2010-01-05T03:17:37Z
experimental_condition_ontology
XCO:0000077
tobacco use
XCO:0000077
The use of any product made for human consumption from Nicotiana tabacum.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigar, a rolled cylinder of tobacco wrapped in tobacco leaves.
mshimoyama
2010-01-05T03:17:52Z
experimental_condition_ontology
Cigar Smoking NCI Thesaurus
XCO:0000078
cigar smoking
XCO:0000078
The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigar, a rolled cylinder of tobacco wrapped in tobacco leaves.
http://medical-dictionary.thefreedictionary.com
Cigar Smoking NCI Thesaurus
NCI:C19702
The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigarette, a small roll of finely cut tobacco enclosed in a wrapper of thin paper.
mshimoyama
2010-01-05T03:18:03Z
experimental_condition_ontology
Cigarette Smoking_NCI Thesaurus
XCO:0000079
cigarette smoking
XCO:0000079
The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigarette, a small roll of finely cut tobacco enclosed in a wrapper of thin paper.
http://medical-dictionary.thefreedictionary.com
Cigarette Smoking_NCI Thesaurus
NCI:C18270
Mastication of a form of the prepared leaves of Nicotiana tabacum that is chewed.
mshimoyama
2010-01-05T03:18:13Z
experimental_condition_ontology
XCO:0000080
tobacco chewing
XCO:0000080
Mastication of a form of the prepared leaves of Nicotiana tabacum that is chewed.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
The attitude or posture of the body.
mshimoyama
2010-03-04T09:05:26Z
experimental_condition_ontology
posture
XCO:0000081
body position
XCO:0000081
The attitude or posture of the body.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A position of rest in which the weight is largely supported by the buttocks, usually with the body vertical.
mshimoyama
2010-03-04T09:06:36Z
experimental_condition_ontology
seated
XCO:0000082
sitting position
XCO:0000082
A position of rest in which the weight is largely supported by the buttocks, usually with the body vertical.
Encarta:Encarta_World_English_Dictionary
A position in which an organism is upright balanced on two legs for bipedal organisms or four legs for quadrapedal organisms.
mshimoyama
2010-03-04T09:06:49Z
experimental_condition_ontology
XCO:0000083
standing position
XCO:0000083
A position in which an organism is upright balanced on two legs for bipedal organisms or four legs for quadrapedal organisms.
RGD:MS
A position in which the organism is lying face up.
mshimoyama
2010-03-04T09:07:12Z
experimental_condition_ontology
XCO:0000084
supine position
XCO:0000084
A position in which the organism is lying face up.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
mshimoyama
2010-03-04T01:56:42Z
experimental_condition_ontology
XCO:0000085
stationary bicycle dynamometer
XCO:0000085
A fixed series of exercises or body movements repeated at intervals over a specified period of time as part of a program to improve strength, aerobic capacity or other elements of fitness.
mshimoyama
2010-03-04T02:09:06Z
experimental_condition_ontology
XCO:0000086
exercise training program
XCO:0000086
A fixed series of exercises or body movements repeated at intervals over a specified period of time as part of a program to improve strength, aerobic capacity or other elements of fitness.
RGD:MS
A standard living condition with the absence of a resident pathogen, a biological agent that causes disease, especially a microorganism such as a bacterium, virus, or fungus.
mshimoyama
2010-06-29T03:35:43Z
experimental_condition_ontology
XCO:0000087
specific pathogen-free condition
XCO:0000087
A standard living condition with the absence of a resident pathogen, a biological agent that causes disease, especially a microorganism such as a bacterium, virus, or fungus.
https://www.dictionary.com
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is a compound or substance that has been purified or prepared, especially artificially.
mshimoyama
2010-11-01T01:00:51Z
experimental_condition_ontology
XCO:0000088
chemical
XCO:0000088
This is any condition in which the main influencing factor is a compound or substance that has been purified or prepared, especially artificially.
https://languages.oup.com/google-dictionary-en/
Any condition in which the main influencing factor is a chemical, i.e., a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules, which has the capacity to promote the formation of neoplasms, new and abnormal growths, specifically those in which cell multiplication is uncontrolled and progressive.
mshimoyama
2010-11-01T01:01:08Z
neoplasm inducing agent
cancer inducing agent
carcinogen
carcinogenic agent
experimental_condition_ontology
XCO:0000089
neoplasm-inducing chemical
XCO:0000089
Any condition in which the main influencing factor is a chemical, i.e., a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules, which has the capacity to promote the formation of neoplasms, new and abnormal growths, specifically those in which cell multiplication is uncontrolled and progressive.
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Collins:Collins_Online_English_Dictionary
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A tetraphene having methyl substituents at the 7- and 12- positions. It is a potent carcinogen and is present in tobacco smoke.
mshimoyama
2010-11-01T01:01:46Z
CHEBI:254496
MESH:D015127
experimental_condition_ontology
7,12-DMBA
7,12-dimethylbenzo[a]anthracene
9,10-Dimethyl-1,2-benzanthracene
DMBA
XCO:0000090
7,12-dimethyltetraphene (DMBA)
XCO:0000090
Any condition in which the main influencing factor is a naturally occurring compound or related synthetic analog with a molecular structure based on the cyclopenta[a]phenanthrene carbon skeleton, that is, a phenanthrene, to the a side of which a three-carbon fragment is fused. According to the definition at the Chemical Entities of Biological Importance (ChEBI) database, 'By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred' which expands the class to include molecules based on but not containing the cannonical arrangement of four fused cycloalkane rings.
mshimoyama
2010-11-01T01:03:53Z
CHEBI:35341
experimental_condition_ontology
XCO:0000091
steroid
XCO:0000091
Any condition in which the main influencing factor is a naturally occurring compound or related synthetic analog with a molecular structure based on the cyclopenta[a]phenanthrene carbon skeleton, that is, a phenanthrene, to the a side of which a three-carbon fragment is fused. According to the definition at the Chemical Entities of Biological Importance (ChEBI) database, 'By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred' which expands the class to include molecules based on but not containing the cannonical arrangement of four fused cycloalkane rings.
http://en.wikipedia.org/wiki/Steroid
http://www.medilexicon.com/medicaldictionary.php?t=22261
The predominant circulating form of estrogen, the female sex hormone.
mshimoyama
2010-11-01T01:04:03Z
CHEBI:16469
experimental_condition_ontology
CO47085
E2
beta-estradiol
estradiol
XCO:0000092
17 beta-estradiol
XCO:0000092
The predominant circulating form of estrogen, the female sex hormone.
http://en.wikipedia.org/wiki/Estradiol
Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form continuous or closed chains linked by alternating double and single bonds that may be represented graphically by multiple interlinking circular or triangular forms.
mshimoyama
2010-11-01T01:07:01Z
CHEBI:33848
experimental_condition_ontology
polycyclic aromatic hydrocarbon
XCO:0000093
polycyclic arene
XCO:0000093
Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form continuous or closed chains linked by alternating double and single bonds that may be represented graphically by multiple interlinking circular or triangular forms.
http://www.thefreedictionary.com/
The removal of one or both ovaries, the female gonads, from an organism.
mshimoyama
2010-11-02T01:28:36Z
experimental_condition_ontology
oophorectomy
XCO:0000094
ovariectomy
XCO:0000094
The removal of one or both ovaries, the female gonads, from an organism.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Surgical removal of both ovaries.
mshimoyama
2010-11-02T01:29:19Z
experimental_condition_ontology
XCO:0000095
bilateral ovariectomy
XCO:0000095
Surgical removal of both ovaries.
RGD:MS
Surgical removal of a single ovary.
mshimoyama
2010-11-02T01:29:34Z
experimental_condition_ontology
XCO:0000096
unilateral ovariectomy
XCO:0000096
Surgical removal of a single ovary.
RGD:MS
Surgical removal of the right ovary.
mshimoyama
2010-11-02T01:29:48Z
experimental_condition_ontology
XCO:0000097
right ovariectomy
XCO:0000097
Surgical removal of the right ovary.
RGD:MS
Surgical removal of the left ovary.
mshimoyama
2010-11-02T01:30:01Z
experimental_condition_ontology
XCO:0000098
left ovariectomy
XCO:0000098
Surgical removal of the left ovary.
RGD:MS
This is any condition in which the major influencing factor is a uniform set of parameters accepted as normal or average and used by general consent as a basis of comparison. It is a baseline condition in which none of the experimental manipulations are performed.
mshimoyama
2010-11-02T02:06:02Z
XCO:0000056
XCO:0000791
naive control condition
standard condition
standard control condition
experimental_condition_ontology
XCO:0000099
control condition
XCO:0000099
This is any condition in which the major influencing factor is a uniform set of parameters accepted as normal or average and used by general consent as a basis of comparison. It is a baseline condition in which none of the experimental manipulations are performed.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A surgical treatment or procedure that is performed as a control and that is similar to but omits a key therapeutic element of the treatment or procedure under investigation.
mshimoyama
2010-11-02T02:06:46Z
experimental_condition_ontology
XCO:0000100
sham surgical control condition
XCO:0000100
A surgical treatment or procedure that is performed as a control and that is similar to but omits a key therapeutic element of the treatment or procedure under investigation.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
A treatment used as a control in which a saline or other solution is administered in the same manner as the experimental solution minus the key element of the experimental solution.
mshimoyama
2010-11-02T02:07:02Z
PMID:28928461
experimental_condition_ontology
vehicle control diet
XCO:0000101
vehicle control condition
XCO:0000101
A treatment used as a control in which a saline or other solution is administered in the same manner as the experimental solution minus the key element of the experimental solution.
ISBN-13:9780781733908
https://www.merriam-webster.com/
Abstaining from the consumption of food, often for a specified period of time.
mshimoyama
2010-11-08T09:37:31Z
experimental_condition_ontology
XCO:0000102
fasting
XCO:0000102
Abstaining from the consumption of food, often for a specified period of time.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A mixture in which molecules of glucose, the monosaccharide sugar (C6H12O6) which is the end product of carbohydrate metabolism, and the chief source of energy for living organisms, are distributed uniformly throughout another substance (the solvent), usually water, so that the mixture is homogeneous at the molecular level.
mshimoyama
2010-11-08T09:40:03Z
experimental_condition_ontology
dextrose solution
XCO:0000103
glucose solution
XCO:0000103
A mixture in which molecules of glucose, the monosaccharide sugar (C6H12O6) which is the end product of carbohydrate metabolism, and the chief source of energy for living organisms, are distributed uniformly throughout another substance (the solvent), usually water, so that the mixture is homogeneous at the molecular level.
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A mixture in which 2.8 moles of glucose, the monosaccharide sugar (C6H12O6) which is the end product of carbohydrate metabolism, and the chief source of energy for living organisms, are distributed uniformly throughout a sufficient volume of another substance (the solvent), usually water, so that the mixture is homogeneous at the molecular level and the final volume is one liter.
mshimoyama
2010-11-08T09:40:19Z
experimental_condition_ontology
XCO:0000104
glucose solution, 2.8M
XCO:0000104
A mixture in which 2.8 moles of glucose, the monosaccharide sugar (C6H12O6) which is the end product of carbohydrate metabolism, and the chief source of energy for living organisms, are distributed uniformly throughout a sufficient volume of another substance (the solvent), usually water, so that the mixture is homogeneous at the molecular level and the final volume is one liter.
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Surgical removal of part or all of the pancreas, the combined endocrine/exocrine gland situated transversely behind the stomach, between the spleen and the duodenum.
mshimoyama
2010-11-10T02:19:58Z
experimental_condition_ontology
XCO:0000105
pancreatectomy
XCO:0000105
Surgical removal of part or all of the pancreas, the combined endocrine/exocrine gland situated transversely behind the stomach, between the spleen and the duodenum.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
This is any condition in which the main influencing factor is a drug or agent used to reduce or eliminate pain or sensation.
mshimoyama
2011-01-21T09:44:08Z
experimental_condition_ontology
XCO:0000106
anesthetic/analgesic
XCO:0000106
This is any condition in which the main influencing factor is a drug or agent used to reduce or eliminate pain or sensation.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Short to intermediate acting barbiturate used as a sedative and hypnotic.
mshimoyama
2011-01-21T09:45:03Z
experimental_condition_ontology
XCO:0000107
pentobarbital
XCO:0000107
Short to intermediate acting barbiturate used as a sedative and hypnotic.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Sodium salt of pentobarbital, a short to intermediate acting barbiturate used as a sedative and hypnotic.
mshimoyama
2011-01-21T09:46:40Z
experimental_condition_ontology
XCO:0000108
pentobarbital, sodium
XCO:0000108
Sodium salt of pentobarbital, a short to intermediate acting barbiturate used as a sedative and hypnotic.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Potent inhalational anesthetic.
mshimoyama
2011-01-21T09:48:47Z
experimental_condition_ontology
XCO:0000109
isoflurane
XCO:0000109
Potent inhalational anesthetic.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A position in which the organism is lying face down.
mshimoyama
2011-02-07T01:44:52Z
experimental_condition_ontology
XCO:0000110
prone position
XCO:0000110
A position in which the organism is lying face down.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
mshimoyama
2011-02-08T02:22:15Z
experimental_condition_ontology
XCO:0000111
temperature exposure
XCO:0000111
Surgical removal of a single kidney.
mshimoyama
2011-11-02T02:08:41Z
experimental_condition_ontology
XCO:0000112
unilateral nephrectomy
XCO:0000112
Surgical removal of a single kidney.
RGD:MS
Surgical removal of the right kidney.
mshimoyama
2011-11-02T02:11:31Z
experimental_condition_ontology
XCO:0000113
right nephrectomy
XCO:0000113
Surgical removal of the right kidney.
RGD:MS
Surgical removal of the left kidney.
mshimoyama
2011-11-02T02:12:44Z
experimental_condition_ontology
XCO:0000114
left nephrectomy
XCO:0000114
Surgical removal of the left kidney.
RGD:MS
Any fluid which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
mshimoyama
2012-01-09T01:29:00Z
experimental_condition_ontology
XCO:0000115
perfusate
XCO:0000115
Any fluid which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A buffered, aqueous solution usually containing the cations sodium, potassium, calcium and magnesium, and anions chloride, sulfate, bicarbonate and phosphate and often including glucose as an energy source which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
mshimoyama
2012-01-09T01:29:11Z
experimental_condition_ontology
Krebs-Henseleit buffer perfusate
Krebs-Henseleit solution perfusate
Krebs-Ringer buffer perfusate
Krebs-Ringer solution perfusate
XCO:0000116
Kreb's solution perfusate
XCO:0000116
A buffered, aqueous solution usually containing the cations sodium, potassium, calcium and magnesium, and anions chloride, sulfate, bicarbonate and phosphate and often including glucose as an energy source which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Product_Information_Sheet/1/k3753pis.Par.0001.File.tmp/k3753pis.pdf
A fluid containing a specified amount of a chemical salt, for example sodium chloride, which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
mshimoyama
2012-01-09T01:29:28Z
experimental_condition_ontology
XCO:0000117
saline solution perfusate
XCO:0000117
A fluid containing a specified amount of a chemical salt, for example sodium chloride, which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
Collins:Collins_Online_English_Dictionary
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which a fluid which has been injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel, remains in but is no longer actively passed through the organ or tissue for a specified period of time.
mshimoyama
2012-01-09T01:29:47Z
experimental_condition_ontology
XCO:0000118
perfusate suspended
XCO:0000118
A condition in which a fluid which has been injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel, remains in but is no longer actively passed through the organ or tissue for a specified period of time.
Collins:Collins_Online_English_Dictionary
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
This is any condition in which the main influencing factor is an amino acid, any naturally occurring or synthetic organic compound containing an amino group, a carboxylic acid group and a side chain. An amino acid may be administered as a nutritional supplement or as a drug.
JSmith
2012-02-16T12:55:34Z
CHEBI:33709
MESH:D000596
amino acids
experimental_condition_ontology
XCO:0000119
amino acid
XCO:0000119
This is any condition in which the main influencing factor is an amino acid, any naturally occurring or synthetic organic compound containing an amino group, a carboxylic acid group and a side chain. An amino acid may be administered as a nutritional supplement or as a drug.
https://en.wikipedia.org/wiki/Amino_acid
https://www.merriam-webster.com/
A substance or compound which interferes with a chemical reaction or a molecular or physiological process or activity.
JSmith
2012-02-16T01:09:21Z
experimental_condition_ontology
XCO:0000120
inhibitor
XCO:0000120
A substance or compound which interferes with a chemical reaction or a molecular or physiological process or activity.
RGD:JRS
http://medical-dictionary.thefreedictionary.com/inhibitor
A basic amino acid, commonly known as L-NAME, used as a non-selective inhibitor of nitric oxide synthase.
JSmith
2012-02-16T01:15:20Z
CAS:51298-62-5
MESH:D019331
chembl.compound:CHEMBL7890
pubchem.compound:39836
L-NAME
experimental_condition_ontology
XCO:0000121
NG-nitroarginine methyl ester
XCO:0000121
A basic amino acid, commonly known as L-NAME, used as a non-selective inhibitor of nitric oxide synthase.
MESH:D019331
A chemical which tends to increase the excretion of urine.
JSmith
2012-02-16T01:51:41Z
experimental_condition_ontology
XCO:0000122
diuretic
XCO:0000122
A chemical which tends to increase the excretion of urine.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A compound containing a sulfonamide functional group. A sulfonamide functional group contains sulfonyl connected to an amine group and has the general structure R-S(=O)2-NH2. Sulfonamide also refers to several classes of drugs which include antimicrobial 'sulfa drugs', anticonvulsants and the sulfonylureas and thiazide diuretics.
JSmith
2012-02-16T01:52:39Z
CHEBI:35358
experimental_condition_ontology
XCO:0000123
sulfonamide
XCO:0000123
A compound containing a sulfonamide functional group. A sulfonamide functional group contains sulfonyl connected to an amine group and has the general structure R-S(=O)2-NH2. Sulfonamide also refers to several classes of drugs which include antimicrobial 'sulfa drugs', anticonvulsants and the sulfonylureas and thiazide diuretics.
http://en.eikipedia.org/wiki/
This is any condition whose main influencing factor is furosemide, a diuretic drug which inhibits Nkcc2 (Slc12a1), one of the Na-K symporters and reduces the reabsorption of sodium chloride. Furosemide is used experimentally for sodium depletion.
JSmith
2012-02-16T01:53:25Z
CHEBI:47426
CID:3440
4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid
experimental_condition_ontology
Frusemide
Lasix
XCO:0000124
furosemide
XCO:0000124
This is any condition whose main influencing factor is furosemide, a diuretic drug which inhibits Nkcc2 (Slc12a1), one of the Na-K symporters and reduces the reabsorption of sodium chloride. Furosemide is used experimentally for sodium depletion.
http://en.eikipedia.org/wiki/
A chemical substance which in its endogenous state is produced by an organ, cells of an organ or scattered cells, having a specific regulatory affect on the activity of an organ or tissue.
JSmith
2012-02-16T02:54:55Z
experimental_condition_ontology
XCO:0000125
hormone
XCO:0000125
A chemical substance which in its endogenous state is produced by an organ, cells of an organ or scattered cells, having a specific regulatory affect on the activity of an organ or tissue.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A peptide hormone which increases blood pressure by causing blood vessel constriction. Part of the renin-angiotensin system.
JSmith
2012-02-16T03:00:38Z
experimental_condition_ontology
XCO:0000126
angiotensin
XCO:0000126
A peptide hormone which increases blood pressure by causing blood vessel constriction. Part of the renin-angiotensin system.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A catecholamine neurotransmitter and stress hormone with multiple physiological roles including affects on heart rate, blood pressure and vascular tone.
JSmith
2012-02-16T03:01:05Z
noradrenaline
experimental_condition_ontology
XCO:0000127
norepinephrine
XCO:0000127
A catecholamine neurotransmitter and stress hormone with multiple physiological roles including affects on heart rate, blood pressure and vascular tone.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
JSmith
2012-02-16T03:23:23Z
experimental_condition_ontology
XCO:0000128
drink with chemical additive
true
XCO:0000128
Drinking water with a specified concentration of NG-Nitroarginine Methyl Ester (L-NAME) added to it. L-NAME is used as a non-selective inhibitor of nitric oxide synthase.
JSmith
2012-02-16T03:23:57Z
water with L-NAME
experimental_condition_ontology
XCO:0000129
water with NG-Nitroarginine Methyl Ester
true
XCO:0000129
Drinking water with a specified concentration of NG-Nitroarginine Methyl Ester (L-NAME) added to it. L-NAME is used as a non-selective inhibitor of nitric oxide synthase.
PGA:Renal_protocol
An analgesic and anesthetic which functions as a noncompetitive NMDA receptor (NMDAR) antagonist, binding to the allosteric site of the NMDA receptor and effectively inhibiting its channel.
JSmith
2012-03-15T07:33:06Z
CHEBI:6121
pubchem.compound:3821
experimental_condition_ontology
XCO:0000130
ketamine
XCO:0000130
An analgesic and anesthetic which functions as a noncompetitive NMDA receptor (NMDAR) antagonist, binding to the allosteric site of the NMDA receptor and effectively inhibiting its channel.
http://en.wikipedia.org/wiki/Ketamine
An alpha2-adrenergic receptor agonist used for sedation, anesthesia, muscle relaxation, and analgesia in animals.
JSmith
2012-03-15T07:34:39Z
CHEBI:165540
chembl.compound:CHEMBL297362
pubchem.compound:5707
experimental_condition_ontology
XCO:0000131
xylazine
XCO:0000131
An alpha2-adrenergic receptor agonist used for sedation, anesthesia, muscle relaxation, and analgesia in animals.
http://en.wikipedia.org/wiki/Xylazine
A phenothiazine-derivative antipsychotic drug used in animals as a sedative and antiemetic and which can also cause peripheral vasodilation.
JSmith
2012-03-15T07:39:01Z
CHEBI:44932
CID:6077
experimental_condition_ontology
XCO:0000132
acepromazine
XCO:0000132
A phenothiazine-derivative antipsychotic drug used in animals as a sedative and antiemetic and which can also cause peripheral vasodilation.
http://en.wikipedia.org/wiki/Acepromazine
A condition in which the major influencing factor is a chemical compound to which the body can mount a specific localized or systemic immune reaction, e.g. a T cell or B cell response.
JSmith
2012-03-15T07:42:13Z
experimental_condition_ontology
XCO:0000133
antigen
XCO:0000133
A condition in which the major influencing factor is a chemical compound to which the body can mount a specific localized or systemic immune reaction, e.g. a T cell or B cell response.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
RGD:JRS
A synthetic choline ester that acts as a non-selective muscarinic receptor agonist, that is, a chemical which when bound to the receptor produces a physiologic reaction typical of the naturally occurring ligand, in the parasympathetic nervous system.
JSmith
2012-03-15T07:45:00Z
CHEBI:6804
experimental_condition_ontology
XCO:0000134
methacholine
XCO:0000134
A synthetic choline ester that acts as a non-selective muscarinic receptor agonist, that is, a chemical which when bound to the receptor produces a physiologic reaction typical of the naturally occurring ligand, in the parasympathetic nervous system.
http://en.wikipedia.org/wiki/Methacholine
A drug or other chemical that can combine with a receptor to produce a physiologic reaction typical of a naturally occurring substance. A receptor is a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect in the cell.
JSmith
2012-03-15T07:46:38Z
experimental_condition_ontology
XCO:0000135
receptor agonist
XCO:0000135
A drug or other chemical that can combine with a receptor to produce a physiologic reaction typical of a naturally occurring substance. A receptor is a molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect in the cell.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
JSmith
2012-03-15T07:48:19Z
experimental_condition_ontology
XCO:0000136
enzyme substrate
XCO:0000136
An oligopeptide substrate for continuous spectrophotometric assay of angiotensin converting enzyme (ACE) which hydrolyzes FAPGG to furylacryloylphenylalanine (FAP) and glycylglycine with a resulting decrease in absorbance at 340 nm.
JSmith
2012-03-15T07:48:41Z
CAS:64566-61-6
pubchem.compound:6438387
3-(2-FurylAcryloyl)-L-PHE-GLY-GLY
FurylAcrylolPhenylalanylGlycylGlycine
experimental_condition_ontology
XCO:0000137
FAPGG
XCO:0000137
An oligopeptide substrate for continuous spectrophotometric assay of angiotensin converting enzyme (ACE) which hydrolyzes FAPGG to furylacryloylphenylalanine (FAP) and glycylglycine with a resulting decrease in absorbance at 340 nm.
http://www.sigmaaldrich.com/catalog/product/sigma/f7131?lang=en®ion=US
http://www.trinitybiotech.com/Product%20Documents/305-10-29%20EN.pdf
Methylene blue is monoamine oxidase inhibitor and nitric oxide synthase inhibitor, as well as a cationic dye used as a redox indicator.
JSmith
2012-03-15T07:51:22Z
CHEBI:6872
pubchem.compound:6099
methylthioninium chloride
experimental_condition_ontology
XCO:0000138
methylene blue
XCO:0000138
Methylene blue is monoamine oxidase inhibitor and nitric oxide synthase inhibitor, as well as a cationic dye used as a redox indicator.
RGD:SL
A condition in which the main influencing factor is a molecule that directly or indirectly acts upon blood vessels to cause constriction or dilation.
JSmith
2012-03-15T07:53:30Z
experimental_condition_ontology
XCO:0000139
vasoactive chemical
XCO:0000139
A condition in which the main influencing factor is a molecule that directly or indirectly acts upon blood vessels to cause constriction or dilation.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
A condition in which the main influencing factor is a molecule that functions to dilate or increase the interior diameter of blood vessels.
JSmith
2012-03-15T07:55:13Z
experimental_condition_ontology
XCO:0000140
vasodilator
XCO:0000140
A condition in which the main influencing factor is a molecule that functions to dilate or increase the interior diameter of blood vessels.
Gale:Gale_Encyclopedia_of_Medicine
A condition in which the main influencing factor is a molecule that acts to constrict or reduce the interior diameter of blood vessels.
JSmith
2012-03-15T07:56:15Z
experimental_condition_ontology
vasopressor
XCO:0000141
vasoconstrictor
XCO:0000141
A condition in which the main influencing factor is a molecule that acts to constrict or reduce the interior diameter of blood vessels.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
The red-coloured inorganic salt with the formula Na2[Fe(CN)5NO]?2H2O used as a potent vasodilator.
JSmith
2012-03-15T07:58:24Z
CHEBI:29321
CID:11953895
SNP
disodium pentacyanonitrosylferrate(2-) dehydrate
nitroprusside disodium dihydrate
sodium nitroferricyanide(III) dihydrate
sodium pentacyanidonitrosylferrate(2-)
sodium pentacyanidonitrosylferrate(III)
experimental_condition_ontology
XCO:0000142
sodium nitroprusside
XCO:0000142
The red-coloured inorganic salt with the formula Na2[Fe(CN)5NO]?2H2O used as a potent vasodilator.
http://en.wikipedia.org/wiki/Sodium_nitroprusside
An organic, polyatomic cation, formed as an ester of acetic acid and choline, that acts as a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms.
JSmith
2012-03-15T08:00:34Z
CHEBI:15355
pubchem.compound:187
experimental_condition_ontology
XCO:0000143
acetylcholine
XCO:0000143
An organic, polyatomic cation, formed as an ester of acetic acid and choline, that acts as a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms.
http://en.wikipedia.org/wiki/Acetylcholine
JSmith
2012-03-15T08:01:41Z
experimental_condition_ontology
XCO:0000144
neurotransmitter
XCO:0000144
A selective alpha1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and as a vasoconstrictor.
JSmith
2012-03-15T08:02:39Z
CHEBI:8093
pubchem.compound:6041
experimental_condition_ontology
XCO:0000145
phenylephrine
XCO:0000145
A selective alpha1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and as a vasoconstrictor.
http://en.wikipedia.org/wiki/Phenylephrine
A buffered, aqueous solution usually containing the cations sodium, potassium, calcium and magnesium, and anions chloride, sulfate, bicarbonate and phosphate and often including glucose as an energy source in which a specified amount of the tasteless, odorless, colorless gas essential for aerobic respiration with atomic number 8 has been dissolved, which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
JSmith
2012-03-21T02:07:15Z
experimental_condition_ontology
controlled oxygen content Krebs-Henseleit buffer perfusate
controlled oxygen content Krebs-Henseleit solution perfusate
controlled oxygen content Krebs-Ringer buffer perfusate
controlled oxygen content Krebs-Ringer solution perfusate
XCO:0000146
controlled oxygen content Kreb's solution perfusate
XCO:0000146
A buffered, aqueous solution usually containing the cations sodium, potassium, calcium and magnesium, and anions chloride, sulfate, bicarbonate and phosphate and often including glucose as an energy source in which a specified amount of the tasteless, odorless, colorless gas essential for aerobic respiration with atomic number 8 has been dissolved, which is injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Product_Information_Sheet/1/k3753pis.Par.0001.File.tmp/k3753pis.pdf
A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood.
JSmith
2012-03-21T02:18:12Z
PSS
experimental_condition_ontology
normal saline perfusate
XCO:0000147
physiological salt solution perfusate
XCO:0000147
A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood.
http://en.wikipedia.org/wiki/Saline_%28medicine%29#Normal
A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood, and which contains a specific, controlled concentration of oxygen gas, the tasteless, odorless, colorless gas with atomic number 8 essential for aerobic respiration, dissolved in it.
JSmith
2012-03-21T02:19:03Z
oxygenated PSS
experimental_condition_ontology
XCO:0000148
controlled oxygen content physiological salt solution perfusate
XCO:0000148
A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood, and which contains a specific, controlled concentration of oxygen gas, the tasteless, odorless, colorless gas with atomic number 8 essential for aerobic respiration, dissolved in it.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Saline_%28medicine%29#Normal
Any condition in which the main influencing factor is an atom or molecule that has gained or lost one or more electrons and thereby acquired a charge, or is any of a large class of chemical compounds formed when a positively charged ion (a cation) bonds with a negatively charged ion (an anion).
JSmith
2012-03-23T07:25:49Z
experimental_condition_ontology
XCO:0000149
ion/salt
XCO:0000149
Any condition in which the main influencing factor is an atom or molecule that has gained or lost one or more electrons and thereby acquired a charge, or is any of a large class of chemical compounds formed when a positively charged ion (a cation) bonds with a negatively charged ion (an anion).
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is an atom of potassium, the chemical element with atomic number 19, that has lost one electron, forming a cation with a charge of +1. Potassium is the chief cation of intracellular fluid.
JSmith
2012-03-23T07:31:29Z
CHEBI:29103
K+ ion
experimental_condition_ontology
XCO:0000150
Not used for potassium salt in animal feed. For that application XCO:0000032, "controlled potassium content diet" is used.
potassium ion
XCO:0000150
A condition in which the main influencing factor is an atom of potassium, the chemical element with atomic number 19, that has lost one electron, forming a cation with a charge of +1. Potassium is the chief cation of intracellular fluid.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
JSmith
2012-03-23T08:10:45Z
experimental_condition_ontology
XCO:0000151
chemical time series
XCO:0000151
The condition of exposing an organism, organ or tissue to a series of increasing or decreasing doses of a drug or other chemical from which a single measurement value is obtained.
JSmith
2012-03-23T08:11:18Z
experimental_condition_ontology
XCO:0000152
drug dose time series
XCO:0000152
The condition of exposing an organism, organ or tissue to a series of increasing or decreasing doses of a drug or other chemical from which a single measurement value is obtained.
RGD:JRS
A predetermined and specified amount of time during which an experimental specimen sits undisturbed, for example to allow a chemical reaction to proceed.
JSmith
2012-03-26T10:46:30Z
sample room temperature incubation
experimental_condition_ontology
XCO:0000153
sample resting period
XCO:0000153
A predetermined and specified amount of time during which an experimental specimen sits undisturbed, for example to allow a chemical reaction to proceed.
RGD:JRS
This is any condition in which the main influencing factor is a homogeneous mixture of one or more ions, i.e. atoms or molecules that have gained or lost electron(s) and thereby acquired a charge, or one or more salts, i.e. members of the large class of chemical compounds formed when a positively charged ion (a cation) bonds with a negatively charged ion (an anion), dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2012-03-26T04:34:54Z
experimental_condition_ontology
XCO:0000154
ion/salt solution
XCO:0000154
This is any condition in which the main influencing factor is a homogeneous mixture of one or more ions, i.e. atoms or molecules that have gained or lost electron(s) and thereby acquired a charge, or one or more salts, i.e. members of the large class of chemical compounds formed when a positively charged ion (a cation) bonds with a negatively charged ion (an anion), dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2012-03-26T04:36:15Z
CHEBI:26710
salt solution
experimental_condition_ontology
saline solution
XCO:0000155
sodium chloride solution
XCO:0000155
A condition in which the main influencing factor is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
This is a condition in which the main influencing factor is a solution of sodium chloride (NaCl) and water in which the level of NaCl is maintained at a mass concentration of 9 grams per liter (0.9 grams per 100 mls of solution, or 0.9 % m/v). The osmolarity of normal saline is a close approximation to the osmolarity of NaCl in blood.
JSmith
2012-03-26T04:56:10Z
CHEBI:26710
normal saline
experimental_condition_ontology
0.9% Sodium Chloride Injection
XCO:0000156
0.9% sodium chloride solution
XCO:0000156
This is a condition in which the main influencing factor is a solution of sodium chloride (NaCl) and water in which the level of NaCl is maintained at a mass concentration of 9 grams per liter (0.9 grams per 100 mls of solution, or 0.9 % m/v). The osmolarity of normal saline is a close approximation to the osmolarity of NaCl in blood.
http://en.wikipedia.org/wiki/Saline_%28medicine%29
The use of manual or mechanical means to limit some or all of an animal's normal movement for the purpose of examination, collection of samples, drug administration, therapy, or experimental manipulation.
JSmith
2012-06-07T12:30:41Z
experimental_condition_ontology
XCO:0000157
physical restraint
XCO:0000157
The use of manual or mechanical means to limit some or all of an animal's normal movement for the purpose of examination, collection of samples, drug administration, therapy, or experimental manipulation.
http://grants.nih.gov/grants/olaw/Guide-for-the-care-and-use-of-Laboratory-animals.pdf
The use of mechanical means, i.e. a manufactured apparatus or machine, to limit some or all of an animal's normal movements.
JSmith
2012-06-07T12:42:46Z
experimental_condition_ontology
XCO:0000158
physical restraint in mechanical restrainer
XCO:0000158
The use of mechanical means, i.e. a manufactured apparatus or machine, to limit some or all of an animal's normal movements.
RGD:JRS
http://grants.nih.gov/grants/olaw/Guide-for-the-care-and-use-of-Laboratory-animals.pdf
The use of a tube type rodent restrainer, that is, a hollow cylinder usually made of a rigid clear material in a size that approximates the size of the animal and can be capped at one or both ends to prevent escape, to limit some or all of an animal's normal movements.
JSmith
2012-06-07T12:43:33Z
experimental_condition_ontology
XCO:0000159
physical restraint in tube type rodent restrainer
XCO:0000159
The use of a tube type rodent restrainer, that is, a hollow cylinder usually made of a rigid clear material in a size that approximates the size of the animal and can be capped at one or both ends to prevent escape, to limit some or all of an animal's normal movements.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
http://grants.nih.gov/grants/olaw/Guide-for-the-care-and-use-of-Laboratory-animals.pdf
A substance that binds to a receptor without eliciting a biological response, blocking binding of substances that could elicit such responses.
JSmith
2012-07-03T03:15:44Z
experimental_condition_ontology
XCO:0000160
receptor antagonist
XCO:0000160
A substance that binds to a receptor without eliciting a biological response, blocking binding of substances that could elicit such responses.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
This is any condition whose main influencing factor is losartan, an angiotensin II receptor antagonist and vasodilator which consists of a biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position. Losartan also has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position.
JSmith
2012-07-09T10:53:01Z
CHEBI:6541
experimental_condition_ontology
XCO:0000161
losartan
XCO:0000161
Nicotinic acetylcholine receptor antagonist, ganglionic blocking agent and vasodilator which consists of a dication whose structure comprises a pentane backbone linking two 1-methylpyrrolidinium groups.
JSmith
2012-07-09T10:58:54Z
CHEBI:347401
CHEBI:55326
experimental_condition_ontology
XCO:0000162
pentolinium
XCO:0000162
This is any condition in which the main influencing factor is drinking water in which the amount of one or more solutes are adjusted to a requirement.
JSmith
2012-07-09T11:14:14Z
experimental_condition_ontology
XCO:0000163
controlled content drinking water
XCO:0000163
This is any condition in which the main influencing factor is drinking water in which the amount of one or more solutes are adjusted to a requirement.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
A drink made up of water and a specified amount of sodium, i.e. sodium ions, consumed by an organism as part of an experiment. A sodium ion is an atom of sodium, the chemical element with atomic number 11, that has lost one electron, forming a cation with a charge of +1.
JSmith
2012-07-09T11:19:29Z
experimental_condition_ontology
XCO:0000164
controlled sodium content drinking water
XCO:0000164
A drink made up of water and a specified amount of sodium, i.e. sodium ions, consumed by an organism as part of an experiment. A sodium ion is an atom of sodium, the chemical element with atomic number 11, that has lost one electron, forming a cation with a charge of +1.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Any process involving manual and instrumental techniques for incision or excision of a part of an organism to investigate and/or treat a pathological condition.
JSmith
2012-07-11T01:38:55Z
experimental_condition_ontology
XCO:0000165
surgical manipulation
XCO:0000165
Any process involving manual and instrumental techniques for incision or excision of a part of an organism to investigate and/or treat a pathological condition.
http://en.wikipedia.org/wiki/Surgery
Any experimental condition in which the internal or external environment of an organ, that is, a differentiated, structural part of a system of the body that performs a specific function, is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body.
JSmith
2012-07-11T02:55:03Z
experimental_condition_ontology
XCO:0000166
controlled in situ organ condition
XCO:0000166
Any experimental condition in which the internal or external environment of an organ, that is, a differentiated, structural part of a system of the body that performs a specific function, is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body.
RGD:JRS
RGD:MRD
http://www.thefreedictionary.com/
Any experimental condition in which the internal or external environment of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body.
JSmith
2012-07-11T03:01:51Z
experimental_condition_ontology
XCO:0000167
controlled in situ kidney condition
XCO:0000167
Any experimental condition in which the internal or external environment of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
RGD:JRS
Condition in which the difference in pressure between the arteries and veins in the kidney, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is experimentally regulated, for example by injecting or pumping a fluid into the kidney at a specified pressure or by regulating the blood flow through the kidney, without removal of the organ from the body.
JSmith
2012-07-11T03:07:44Z
experimental_condition_ontology
XCO:0000168
controlled in situ renal perfusion pressure
XCO:0000168
Condition in which the difference in pressure between the arteries and veins in the kidney, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is experimentally regulated, for example by injecting or pumping a fluid into the kidney at a specified pressure or by regulating the blood flow through the kidney, without removal of the organ from the body.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Any chemical to which a tracer has been added such as the addition of a fluorescent tag or inclusion of a radioactive element during synthesis.
JSmith
2012-07-11T03:39:04Z
experimental_condition_ontology
XCO:0000169
labeled chemical
XCO:0000169
Any chemical to which a tracer has been added such as the addition of a fluorescent tag or inclusion of a radioactive element during synthesis.
RGD:JRS
Chemical to which a fluorescent tag has been added as a tracer.
JSmith
2012-07-11T03:51:55Z
experimental_condition_ontology
XCO:0000170
fluorescently labeled chemical
XCO:0000170
Chemical to which a fluorescent tag has been added as a tracer.
RGD:JRS
Chemical into which a radioactive element has been incorporated as a tracer.
JSmith
2012-07-11T03:53:33Z
experimental_condition_ontology
XCO:0000171
radioactively labeled chemical
XCO:0000171
Chemical into which a radioactive element has been incorporated as a tracer.
RGD:JRS
Any of a group of organic compounds that includes sugars, starches, celluloses, and gums and serves as a major energy source in the diet of animals.
JSmith
2012-07-11T04:09:48Z
CHEBI:16646
experimental_condition_ontology
XCO:0000172
carbohydrate
XCO:0000172
Any of a group of organic compounds that includes sugars, starches, celluloses, and gums and serves as a major energy source in the diet of animals.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
This is any condition whose main influencing factor is a polysaccharide, a macromolecule consisting of large numbers (>10) of monosaccharide residues, that is, simple carbohydrate residues each consisting of a single basic sugar unit with the general formula (CH2O)n, linked glycosidically.
JSmith
2012-07-11T04:13:15Z
CHEBI:18154
polysaccharides
experimental_condition_ontology
XCO:0000173
polysaccharide
XCO:0000173
This is any condition whose main influencing factor is a polysaccharide, a macromolecule consisting of large numbers (>10) of monosaccharide residues, that is, simple carbohydrate residues each consisting of a single basic sugar unit with the general formula (CH2O)n, linked glycosidically.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration.
JSmith
2012-07-11T04:15:22Z
CHEBI:15443
experimental_condition_ontology
XCO:0000174
inulin
XCO:0000174
A fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Inulin, a fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration, into which the mass 3 radioactive isotope of hydrogen has been incorporated as a tracer.
JSmith
2012-07-11T04:18:17Z
3H-inulin
experimental_condition_ontology
XCO:0000175
tritiated inulin
XCO:0000175
Inulin, a fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration, into which the mass 3 radioactive isotope of hydrogen has been incorporated as a tracer.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
Any of numerous proteins or conjugated proteins produced by living organisms and functioning as specialized catalysts for biochemical reactions.
JSmith
2012-07-12T05:06:15Z
experimental_condition_ontology
XCO:0000176
enzyme
XCO:0000176
Any of numerous proteins or conjugated proteins produced by living organisms and functioning as specialized catalysts for biochemical reactions.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
An enzyme in blood formed from prothrombin that facilitates blood clotting by reacting with fibrinogen to form fibrin, as well as participating in additional steps in the coagulation pathway.
JSmith
2012-07-12T05:13:12Z
EC:3.4.21.5
experimental_condition_ontology
XCO:0000177
thrombin
XCO:0000177
An enzyme in blood formed from prothrombin that facilitates blood clotting by reacting with fibrinogen to form fibrin, as well as participating in additional steps in the coagulation pathway.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
http://en.wikipedia.org/wiki/Thrombin
A non-competitive inhibitor of the sarco / endoplasmic reticulum Ca2+ ATPase (SERCA) class of enzymes. Acts as a non-phorbol-ester-type tumor promoter and acts as an inhibitor of calcium ATPase of endoplasmic reticulum, leading to an increase in cytoplasmic calcium ions.
JSmith
2012-07-12T05:24:18Z
CHEBI:9516
experimental_condition_ontology
XCO:0000178
thapsigargin
XCO:0000178
A non-competitive inhibitor of the sarco / endoplasmic reticulum Ca2+ ATPase (SERCA) class of enzymes. Acts as a non-phorbol-ester-type tumor promoter and acts as an inhibitor of calcium ATPase of endoplasmic reticulum, leading to an increase in cytoplasmic calcium ions.
Mondofacto:Mondofacto_Online_Medical_Dictionary
http://en.wikipedia.org/wiki/Thapsigargin
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between 10 and 120 nm. Radiation (i.e. ultraviolet light) at this wavelength is considered ionizing, that is, composed of photons that individually carry enough energy to liberate an electron from an atom or molecule without raising the bulk material to ionization temperature.
JSmith
2012-07-13T12:39:17Z
ionizing UV radiation exposure
experimental_condition_ontology
extreme UV ray exposure
extreme ultraviolet ray exposure
XCO:0000179
ionizing ultraviolet radiation exposure
XCO:0000179
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between 10 and 120 nm. Radiation (i.e. ultraviolet light) at this wavelength is considered ionizing, that is, composed of photons that individually carry enough energy to liberate an electron from an atom or molecule without raising the bulk material to ionization temperature.
http://en.wikipedia.org/wiki/Electromagnetic_Radiation
http://en.wikipedia.org/wiki/Ionizing_radiation
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between 120 and 400 nm. Radiation (i.e. ultraviolet light) at this wavelength does not have sufficient energy to liberate electrons from atoms or molecules although it can induce photochemical reactions, or accelerate radical reactions.
JSmith
2012-07-13T01:00:12Z
non-ionizing UV radiation exposure
near ultraviolet radiation exposure
experimental_condition_ontology
XCO:0000180
non-ionizing ultraviolet radiation exposure
XCO:0000180
The condition of being subjected to electromagnetic radiation, that is, energy emitted and absorbed by charged particles, which exhibits wave-like behavior as it travels and has both electric and magnetic field components, with wavelengths between 120 and 400 nm. Radiation (i.e. ultraviolet light) at this wavelength does not have sufficient energy to liberate electrons from atoms or molecules although it can induce photochemical reactions, or accelerate radical reactions.
http://en.wikipedia.org/wiki/Electromagnetic_Radiation
http://en.wikipedia.org/wiki/Ultraviolet
Condition in which the presence or absence of visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is constrained.
JSmith
2012-07-13T02:59:55Z
experimental_condition_ontology
XCO:0000181
controlled visible light condition
XCO:0000181
Condition in which the presence or absence of visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is constrained.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
Condition in which the natural, usual or environmental level and/or time of exposure to visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is controlled.
JSmith
2012-07-13T03:09:31Z
experimental_condition_ontology
diurnal condition
XCO:0000182
controlled exposure to ambient light
XCO:0000182
Condition in which the natural, usual or environmental level and/or time of exposure to visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is controlled.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
Condition during which visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is removed.
JSmith
2012-07-13T03:12:34Z
experimental_condition_ontology
nocturnal condition
XCO:0000183
controlled exposure to darkness
XCO:0000183
Condition during which visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, is removed.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
The divalent cation of calcium, the chemical element with symbol Ca and atomic number 20.
JSmith
2012-07-13T03:19:56Z
CHEBI:29108
experimental_condition_ontology
XCO:0000184
calcium ion
XCO:0000184
The divalent cation of calcium, the chemical element with symbol Ca and atomic number 20.
http://en.wikipedia.org/wiki/Calcium
A solution of the divalent cation of calcium, the chemical element with symbol Ca and atomic number 20.
JSmith
2012-07-13T03:25:32Z
CHEBI:29108
experimental_condition_ontology
XCO:0000185
calcium ion solution
XCO:0000185
A solution of the divalent cation of calcium, the chemical element with symbol Ca and atomic number 20.
http://en.wikipedia.org/wiki/Calcium
A toxic selective nicotinic cholinergic alkaloid from the seed of Laburnum anagyroides and other Leguminosae. Used in pharmacological studies of nicotinic cholinergic receptors in the brain.
JSmith
2012-07-30T08:40:00Z
CAS:485-35-8
experimental_condition_ontology
baptitoxine
sophorine
XCO:0000186
cytisine
XCO:0000186
A toxic selective nicotinic cholinergic alkaloid from the seed of Laburnum anagyroides and other Leguminosae. Used in pharmacological studies of nicotinic cholinergic receptors in the brain.
Mondofacto:Mondofacto_Online_Medical_Dictionary
A drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia by acting as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor.
JSmith
2012-07-30T08:54:30Z
CAS:7187-66-8
CHEBI:9729
trimetaphan camsilate
experimental_condition_ontology
Arfonad
XCO:0000187
trimethaphan camsylate
XCO:0000187
A drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia by acting as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor.
http://en.wikipedia.org/wiki/Trimethaphan_camsylate
Calcium channel blocker.
JSmith
2012-07-30T09:01:57Z
CAS:72803-02-2
experimental_condition_ontology
PY 108-068
XCO:0000188
darodipine
XCO:0000188
Calcium channel blocker.
http://en.wikipedia.org/wiki/Darodipine
Immobilization of a subject on a frame or platform by securing all four limbs to it, e.g. by taping them to mounts attached to the frame, thereby eliminating the subject's ability to move at will.
JSmith
2012-08-01T04:38:43Z
experimental_condition_ontology
XCO:0000189
physical restraint on immobilization board
XCO:0000189
Immobilization of a subject on a frame or platform by securing all four limbs to it, e.g. by taping them to mounts attached to the frame, thereby eliminating the subject's ability to move at will.
Fink:Encyclopedia_of_Stress
The 10 amino acid cleavage product produced by the action of renin on angiotensinogen. Ang I is apparently inactive unless further cleaved by angiotensin-converting enzyme (ACE) into Ang II.
JSmith
2012-08-09T01:48:44Z
experimental_condition_ontology
XCO:0000190
angiotensin I
XCO:0000190
The 10 amino acid cleavage product produced by the action of renin on angiotensinogen. Ang I is apparently inactive unless further cleaved by angiotensin-converting enzyme (ACE) into Ang II.
PMID:18793332
The 8 amino acid cleavage product produced by the action of angiotensin-converting enzyme (ACE) on Ang I. Ang II is considered to be the main effector of the renin-angiotensin system (RAS), has endocrine, autocrine/paracrine, and intracrine hormone activities in the body and acts as a powerful vasoconstrictor.
JSmith
2012-08-09T01:58:29Z
CHEBI:48432
experimental_condition_ontology
XCO:0000191
angiotensin II
XCO:0000191
The 8 amino acid cleavage product produced by the action of angiotensin-converting enzyme (ACE) on Ang I. Ang II is considered to be the main effector of the renin-angiotensin system (RAS), has endocrine, autocrine/paracrine, and intracrine hormone activities in the body and acts as a powerful vasoconstrictor.
PMID:18793332
The acetate ester of 11-deoxycorticosterone, a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.
JSmith
2012-08-09T02:19:10Z
CHEBI:16973
experimental_condition_ontology
21-hydroxyprogesterone acetate
DOCA
desoxycorticosterone acetate
XCO:0000192
deoxycorticosterone acetate
XCO:0000192
The acetate ester of 11-deoxycorticosterone, a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.
http://en.wikipedia.org/wiki/11-Deoxycorticosterone
Any natural or synthetic complex organic macromolecule composed of chain(s) of amino acids. A peptide can be contain as few as two amino acids; a protein can contain multiple chains composed of hundreds of amino acids.
jsmith
2012-08-27T04:50:37Z
experimental_condition_ontology
polypeptide
XCO:0000193
peptide/protein
XCO:0000193
Any natural or synthetic complex organic macromolecule composed of chain(s) of amino acids. A peptide can be contain as few as two amino acids; a protein can contain multiple chains composed of hundreds of amino acids.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
An immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact only with the antigen that induced its synthesis and with molecules containing structures similar to that antigen. An antigen is any substance capable of inducing a specific immune response, including but not limited to toxins, bacterial proteins and viruses.
jsmith
2012-08-27T05:01:08Z
experimental_condition_ontology
immunoglobulin
XCO:0000194
antibody
XCO:0000194
An immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact only with the antigen that induced its synthesis and with molecules containing structures similar to that antigen. An antigen is any substance capable of inducing a specific immune response, including but not limited to toxins, bacterial proteins and viruses.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
A membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is considered a primary target antigen involved in immune-mediated demyelination.
jsmith
2012-08-27T05:05:03Z
RGD:3102
experimental_condition_ontology
Mog
rMog (recombinant Mog)
XCO:0000195
myelin oligodendrocyte glycoprotein
XCO:0000195
A membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is considered a primary target antigen involved in immune-mediated demyelination.
NCBI_Gene:4340
ATP-sensitive potassium channel inhibitor used as an anti-arrhythmia drug and a hypoglycemic/anti-diabetes drug. In the latter case, the drug causes beta cell membrane depolarization, which in turn results in opening of voltage-dependent calcium channels and subsequent insulin release.
JSmith
2012-09-10T11:39:12Z
CHEBI:5441
glyburide
experimental_condition_ontology
XCO:0000196
glybenclamide
XCO:0000196
ATP-sensitive potassium channel inhibitor used as an anti-arrhythmia drug and a hypoglycemic/anti-diabetes drug. In the latter case, the drug causes beta cell membrane depolarization, which in turn results in opening of voltage-dependent calcium channels and subsequent insulin release.
http://en.wikipedia.org/wiki/Glibenclamide
Any substance that indicates the presence, absence, or concentration of another substance or the degree of reaction between substances by means of a characteristic change, especially in color.
JSmith
2012-09-10T12:25:59Z
experimental_condition_ontology
XCO:0000197
indicator
XCO:0000197
Any substance that indicates the presence, absence, or concentration of another substance or the degree of reaction between substances by means of a characteristic change, especially in color.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Any substance that indicates the concentration of hydrogen ions, that is the acidity level, of a solution by means of a characteristic change, especially in color.
JSmith
2012-09-10T12:30:07Z
experimental_condition_ontology
XCO:0000198
pH indicator
XCO:0000198
Any substance that indicates the concentration of hydrogen ions, that is the acidity level, of a solution by means of a characteristic change, especially in color.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Any substance which indicates the oxidation status of another substance or of a reaction by means of a characteristic change, especially in color.
JSmith
2012-09-10T12:34:38Z
redox indicator
experimental_condition_ontology
XCO:0000199
oxidation-reduction indicator
XCO:0000199
Any substance which indicates the oxidation status of another substance or of a reaction by means of a characteristic change, especially in color.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
A monocarboxylic acid that serves as an intermediate in the metabolism of leucine and a substrate for NADPH-dependent dehydrogenases.
JSmith
2012-09-10T12:50:31Z
CHEBI:48430
pubchem.compound:70
2-Oxoisocaproate
4-methyl-2-oxovaleric acid
alpha-ketoisocaproic acid
experimental_condition_ontology
Ketoleucine
alpha-KIC
XCO:0000200
4-methyl-2-oxopentanoic acid
XCO:0000200
A monocarboxylic acid that serves as an intermediate in the metabolism of leucine and a substrate for NADPH-dependent dehydrogenases.
http://en.wikipedia.org/wiki/Alpha-Ketoisocaproic_acid
Surgical removal of one or both testes.
JSmith
2012-09-10T01:13:58Z
orchidectomy
testectomy
experimental_condition_ontology
XCO:0000201
orchiectomy
XCO:0000201
Surgical removal of one or both testes.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Surgical removal of a single testis.
JSmith
2012-09-10T01:18:15Z
unilateral orchidectomy
experimental_condition_ontology
unilateral testectomy
XCO:0000202
unilateral orchiectomy
XCO:0000202
Surgical removal of a single testis.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Surgical removal of both testes.
JSmith
2012-09-10T01:20:16Z
bilateral orchidectomy
bilateral testectomy
experimental_condition_ontology
castration
XCO:0000203
bilateral orchiectomy
XCO:0000203
Surgical removal of both testes.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
The principal androgenic, that is, male sex hormone. Responsible for regulation of gonadotropic secretion, spermatogenesis and control of other male characteristics.
JSmith
2012-09-10T01:41:13Z
experimental_condition_ontology
XCO:0000204
testosterone
XCO:0000204
The principal androgenic, that is, male sex hormone. Responsible for regulation of gonadotropic secretion, spermatogenesis and control of other male characteristics.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
An agent that causes or increases the frequency of permanent, heritable changes in the DNA sequence or chromosomal structure of a cell or organism.
JSmith
2012-09-11T04:39:32Z
mutagen
experimental_condition_ontology
mutation inducing agent
XCO:0000205
mutation inducing chemical
XCO:0000205
An agent that causes or increases the frequency of permanent, heritable changes in the DNA sequence or chromosomal structure of a cell or organism.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A component of tobacco smoke which has been shown to be mutagenic and carcinogenic in animal studies.
JSmith
2012-09-11T05:01:10Z
experimental_condition_ontology
N,N-diethylnitrosamine
NDEA
diethylnitrosamine
XCO:0000206
N-nitrosodiethylamine
XCO:0000206
A component of tobacco smoke which has been shown to be mutagenic and carcinogenic in animal studies.
PMID:8910949
A condition in which the main influencing factor is 3-methyl-4'-dimethylaminoazobenzene (MDAB), an azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. MDAB is a potent liver carcinogen.
JSmith
2012-09-11T05:33:14Z
CAS:55-80-1
CHEBI:76329
pubchem.compound:5934
4-Dimethylamino-3'-methylazobenzene
methyldimethylaminoazobenzene
experimental_condition_ontology
3'-Me-DAB
3'-methyl-4-(dimethylamino)azobenzene
MDAB
XCO:0000207
3-methyl-4'-dimethylaminoazobenzene
XCO:0000207
A condition in which the main influencing factor is 3-methyl-4'-dimethylaminoazobenzene (MDAB), an azobenzene in which one of the phenyl groups is substituted at position 3 by a methyl group, while the other is substituted at position 4 by a dimethylamino group. MDAB is a potent liver carcinogen.
http://potency.berkeley.edu/chempages/3%27-METHYL-4-DIMETHYLAMINOAZOBENZENE.html
A condition in which the main influencing factor is 2-acetamidofluorene (2-AAF) an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. 2-AAF and a number of its metabolites are both carcinogenic and mutagenic.
JSmith
2012-09-13T06:33:44Z
CHEBI:17356
experimental_condition_ontology
2-AAF
2-acetylaminofluorene
XCO:0000208
2-acetamidofluorene
XCO:0000208
A condition in which the main influencing factor is 2-acetamidofluorene (2-AAF) an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. 2-AAF and a number of its metabolites are both carcinogenic and mutagenic.
http://en.wikipedia.org/wiki/Acetylaminofluorene
JSmith
2012-09-13T06:34:26Z
experimental_condition_ontology
XCO:0000209
hepatectomy
XCO:0000209
A condition involving the surgical excision of part of the liver, the large abdominal organ/gland which functions in the storage and filtration of blood, secretion of bile, and other processes. The partial liver removal may be minor (< 50%) or major (> 50%).
JSmith
2012-09-13T06:34:52Z
PMID:32156510
major hepatectomy
minor hepatectomy
experimental_condition_ontology
XCO:0000210
partial hepatectomy
XCO:0000210
A condition involving the surgical excision of part of the liver, the large abdominal organ/gland which functions in the storage and filtration of blood, secretion of bile, and other processes. The partial liver removal may be minor (< 50%) or major (> 50%).
ISBN-13:9780781733908
PMID:32156510
JSmith
2012-09-13T06:36:13Z
experimental_condition_ontology
XCO:0000211
controlled sucrose content diet
XCO:0000211
A regimen of solid food in which the amount of copper consumed is controlled.
JSmith
2012-09-13T06:36:56Z
controlled Cu content diet
experimental_condition_ontology
XCO:0000212
controlled copper content diet
XCO:0000212
A regimen of solid food in which the amount of copper consumed is controlled.
ISBN-13:9780781733908
https://www.merriam-webster.com
Any condition in which the main influencing factor is arginine (L-arginine), an alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.
JSmith
2012-09-13T06:45:59Z
CHEBI:29016
MESH:D001120
2-amino-5-guanidinopentanoic acid
ARG
L-arginine
R
experimental_condition_ontology
XCO:0000213
arginine
XCO:0000213
Any condition in which the main influencing factor is arginine (L-arginine), an alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.
CHEBI:29016
https://en.wikipedia.org/wiki/Arginine
Any substance that makes another substance active or reactive, induces a chemical reaction, or combines with an enzyme to increase its catalytic activity.
JSmith
2012-10-04T05:09:16Z
experimental_condition_ontology
XCO:0000214
activator
XCO:0000214
Any substance that makes another substance active or reactive, induces a chemical reaction, or combines with an enzyme to increase its catalytic activity.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood, and which contains a specific, controlled concentration of calcium ions, divalent cations of the metallic chemical element with atomic number 20, dissolved in it.
JSmith
2012-10-05T11:11:47Z
experimental_condition_ontology
XCO:0000215
controlled calcium ion content physiological salt solution perfusate
XCO:0000215
A fluid which is injected or pumped into an organ or tissue, usually via blood vessels, composed of a solution of sodium chloride at a concentration which closely approximates the osmolarity of salt in blood, and which contains a specific, controlled concentration of calcium ions, divalent cations of the metallic chemical element with atomic number 20, dissolved in it.
American_Heritage:The_American_Heritage_Science_Dictionary_2005
http://en.wikipedia.org/wiki/Saline_%28medicine%29#Normal
Any chemical substance which increases the activity of an ion channel, one or more membrane-bound globular proteins that allow diffusion of specific ions across a cell membrane.
JSmith
2012-10-04T05:16:39Z
experimental_condition_ontology
ion channel agonist
XCO:0000216
ion channel activator
XCO:0000216
Any chemical substance which increases the activity of an ion channel, one or more membrane-bound globular proteins that allow diffusion of specific ions across a cell membrane.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any chemical substance which increases the activity of a cation channel, one or more membrane-bound globular proteins that allow diffusion of positively charged ions across a cell membrane.
JSmith
2012-10-04T05:40:42Z
experimental_condition_ontology
XCO:0000217
cation channel activator
XCO:0000217
Any chemical substance which increases the activity of a cation channel, one or more membrane-bound globular proteins that allow diffusion of positively charged ions across a cell membrane.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A phorbol ester analog that is an activator of TRPV4 (transient receptor potential cation channel, subfamily V, member 4) channels.
JSmith
2012-10-04T05:41:38Z
CHEBI:295732
pubchem.compound:452544
4-alpha-PDD
experimental_condition_ontology
XCO:0000218
4-alpha-phorbol 12,13-didecanoate
XCO:0000218
A phorbol ester analog that is an activator of TRPV4 (transient receptor potential cation channel, subfamily V, member 4) channels.
http://www.lclabs.com/PRODFILE/P-R/P-2170.php4
A capsaicinoid which is an irritant and a selective TRPV1 (transient receptor potential cation channel, subfamily V, member 1) agonist.
JSmith
2012-10-04T06:08:13Z
CHEBI:46932
8-Methyl-N-vanillylnonanamide
N-(4-Hydroxy-3-methoxybenzyl)-8-methylnonanamide
experimental_condition_ontology
DHC
XCO:0000219
dihydrocapsaicin
XCO:0000219
A capsaicinoid which is an irritant and a selective TRPV1 (transient receptor potential cation channel, subfamily V, member 1) agonist.
http://datasheets.scbt.com/sc-202578.pdf
Any chemical substance which increases the activity of an anion channel, one or more membrane-bound globular proteins that allow diffusion of negatively charged ions across a cell membrane.
JSmith
2012-10-04T06:11:24Z
experimental_condition_ontology
XCO:0000220
anion channel agonist
XCO:0000220
Any chemical substance which increases the activity of an anion channel, one or more membrane-bound globular proteins that allow diffusion of negatively charged ions across a cell membrane.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any chemical substance which decreases or interferes with the activity of an ion channel, one or more membrane-bound globular proteins that allow diffusion of specific ions across a cell membrane.
JSmith
2012-10-04T06:13:42Z
experimental_condition_ontology
ion channel antagonist
XCO:0000221
ion channel inhibitor
XCO:0000221
Any chemical substance which decreases or interferes with the activity of an ion channel, one or more membrane-bound globular proteins that allow diffusion of specific ions across a cell membrane.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any chemical substance which decreases or interferes with the activity of a cation channel, one or more membrane-bound globular proteins that allow diffusion of positively charged ions across a cell membrane.
JSmith
2012-10-05T10:45:01Z
experimental_condition_ontology
cation channel antagonist
XCO:0000222
cation channel inhibitor
XCO:0000222
Any chemical substance which decreases or interferes with the activity of a cation channel, one or more membrane-bound globular proteins that allow diffusion of positively charged ions across a cell membrane.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any chemical substance which decreases or interferes with the activity of an anion channel, one or more membrane-bound globular proteins that allow diffusion of negatively charged ions across a cell membrane.
JSmith
2012-10-05T10:48:12Z
experimental_condition_ontology
anion channel antagonist
XCO:0000223
anion channel inhibitor
XCO:0000223
Any chemical substance which decreases or interferes with the activity of an anion channel, one or more membrane-bound globular proteins that allow diffusion of negatively charged ions across a cell membrane.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
An inorganic dye which also intereacts with many types of proteins including ion channels and enzymes.
JSmith
2012-10-05T11:03:00Z
CHEBI:34956
ammoniated ruthenium oxychloride
experimental_condition_ontology
RuR
XCO:0000224
ruthenium red
XCO:0000224
An inorganic dye which also intereacts with many types of proteins including ion channels and enzymes.
http://en.wikipedia.org/wiki/Ruthenium_red
Any chemical substance which decreases or interferes with the activity of a potassium ion channel, that is, a complex of membrane-bound and membrane-spanning proteins that specifically allow diffusion of positively charged potassium ions across a cell membrane.
JSmith
2012-10-05T11:29:50Z
experimental_condition_ontology
XCO:0000225
potassium channel inhibitor
XCO:0000225
Any chemical substance which decreases or interferes with the activity of a potassium ion channel, that is, a complex of membrane-bound and membrane-spanning proteins that specifically allow diffusion of positively charged potassium ions across a cell membrane.
http://en.wikipedia.org/wiki/Potassium_channel
An 18 amino acid peptide neurotoxin from bee venom which blocks small-conductance Ca2+-activated K+ channels.
JSmith
2012-10-05T11:41:19Z
UniProtKB:P01500
pubchem.compound:16129677
apamine
experimental_condition_ontology
XCO:0000226
apamin
XCO:0000226
An 18 amino acid peptide neurotoxin from bee venom which blocks small-conductance Ca2+-activated K+ channels.
http://en.wikipedia.org/wiki/Apamin
A 37 amino acid peptide neurotoxin from scorpion venom that is a blocker of large- and intermediate-conductance Ca2+-activated K+ channels.
JSmith
2012-10-05T11:53:12Z
UniProtKB:P13487
experimental_condition_ontology
ChTX
ChTX-Lq1
ChTx-a
XCO:0000227
charybdotoxin
XCO:0000227
A 37 amino acid peptide neurotoxin from scorpion venom that is a blocker of large- and intermediate-conductance Ca2+-activated K+ channels.
http://en.wikipedia.org/wiki/Charybdotoxin
A molecular chain compound composed of two or more amino acids joined by peptide bonds that in its endogenous state is produced in one part or organ of the body and initiates or regulates the activity of an organ or a group of cells in another part of the body.
JSmith
2012-10-15T04:30:11Z
experimental_condition_ontology
XCO:0000228
peptide hormone
XCO:0000228
A molecular chain compound composed of two or more amino acids joined by peptide bonds that in its endogenous state is produced in one part or organ of the body and initiates or regulates the activity of an organ or a group of cells in another part of the body.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A condition in which the main influencing factor is a chemical substance the structure of which is based on the basic 17-carbon-atom ring system steroid nucleus but may or may not have the characteristic arrangement of four fused cycloalkane rings, and which is produced in its endogenous state by an organ, cells of an organ or scattered cells, having a specific regulatory affect on the activity of an organ or tissue.
JSmith
2012-10-15T04:36:54Z
CHEBI:26764
experimental_condition_ontology
XCO:0000229
steroid hormone
XCO:0000229
A condition in which the main influencing factor is a chemical substance the structure of which is based on the basic 17-carbon-atom ring system steroid nucleus but may or may not have the characteristic arrangement of four fused cycloalkane rings, and which is produced in its endogenous state by an organ, cells of an organ or scattered cells, having a specific regulatory affect on the activity of an organ or tissue.
CHEBI:35341
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A chemical substance consisting of an amine compound which contains one amino group and was derived from an aromatic amino acid, that in its endogenous state is produced in one part or organ of the body and initiates or regulates the activity of an organ or a group of cells in another part of the body.
JSmith
2012-10-15T04:51:18Z
experimental_condition_ontology
XCO:0000230
monoamine hormone
XCO:0000230
A chemical substance consisting of an amine compound which contains one amino group and was derived from an aromatic amino acid, that in its endogenous state is produced in one part or organ of the body and initiates or regulates the activity of an organ or a group of cells in another part of the body.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Antibody directed against the RT6.1 cell surface alloantigen (also known as ART2, Pta.A2, and Ag-F1). RT6.1 is an allelic form of the RT6 antigen which is expressed on most peripheral T cells but not on thymocytes.
JSmith
2012-10-16T12:39:20Z
Art2 antibody
anti-ADP-ribosyltransferase 2 antibody
experimental_condition_ontology
DS4.23 mAb
anti-Art2.1 mAb
XCO:0000231
anti-RT6.1 antibody
XCO:0000231
Antibody directed against the RT6.1 cell surface alloantigen (also known as ART2, Pta.A2, and Ag-F1). RT6.1 is an allelic form of the RT6 antigen which is expressed on most peripheral T cells but not on thymocytes.
PMID:7559400
A high-molecular-weight polymeric compound composed of nucleotides, each consisting of a purine or pyrimidine base, a ribose or deoxyribose sugar, and a phosphate group.
JSmith
2012-10-16T01:26:26Z
experimental_condition_ontology
XCO:0000232
nucleic acid
XCO:0000232
A high-molecular-weight polymeric compound composed of nucleotides, each consisting of a purine or pyrimidine base, a ribose or deoxyribose sugar, and a phosphate group.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A long, polymeric chain of alternating phosphate and ribose units with the bases adenine, guanine, cytosine, and uracil bonded to the ribose. Although RNA is usually single-stranded it can also exist as RNA:RNA or RNA:DNA double-stranded molecules.
JSmith
2012-10-16T02:15:23Z
RNA
experimental_condition_ontology
XCO:0000233
ribonucleic acid
XCO:0000233
A long, polymeric chain of alternating phosphate and ribose units with the bases adenine, guanine, cytosine, and uracil bonded to the ribose. Although RNA is usually single-stranded it can also exist as RNA:RNA or RNA:DNA double-stranded molecules.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
A long, polymeric chain of alternating phosphate and deoxyribose units with the bases adenine, guanine, cytosine, and thymine bonded to the deoxyribose. DNA can be single stranded or double stranded, that is, composed of either a single polymer or a pair of antiparallel polymers joined by hydrogen bonding between complementary bases.
JSmith
2012-10-16T02:22:54Z
DNA
experimental_condition_ontology
XCO:0000234
deoxyribonucleic acid
XCO:0000234
A long, polymeric chain of alternating phosphate and deoxyribose units with the bases adenine, guanine, cytosine, and thymine bonded to the deoxyribose. DNA can be single stranded or double stranded, that is, composed of either a single polymer or a pair of antiparallel polymers joined by hydrogen bonding between complementary bases.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
Poly I:C is a synthetic analog of dsRNA, which is the ligand of choice for Toll-like receptor 3 (TLR3). Poly(I:C) is composed of a strand of poly(I) annealed to a strand of poly(C).
JSmith
2012-10-16T02:34:34Z
polyinosine-polycytidylic acid
experimental_condition_ontology
XCO:0000235
Poly I:C
XCO:0000235
Poly I:C is a synthetic analog of dsRNA, which is the ligand of choice for Toll-like receptor 3 (TLR3). Poly(I:C) is composed of a strand of poly(I) annealed to a strand of poly(C).
http://www.invivogen.com/tlr3-ligands?gclid=CLDYv5u4wLICFahaMgod_H8AGg
An biological agent that causes disease, especially a living microorganism such as a bacterium, virus, or fungus.
JSmith
2012-10-16T03:04:11Z
experimental_condition_ontology
XCO:0000236
pathogen
XCO:0000236
An biological agent that causes disease, especially a living microorganism such as a bacterium, virus, or fungus.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
A virus which has the potential to cause disease. A virus is one of a group of heterogeneous infective agents characterized by their lack of independent metabolism, their inability to replicate outside a host cell, their simple organization and their unique mode of replication. A virus consists of genetic material--either DNA or RNA--surrounded by a protein coat and, in some cases, by a membranous envelope.
JSmith
2012-10-16T03:06:55Z
virus
experimental_condition_ontology
XCO:0000237
viral pathogen
XCO:0000237
A virus which has the potential to cause disease. A virus is one of a group of heterogeneous infective agents characterized by their lack of independent metabolism, their inability to replicate outside a host cell, their simple organization and their unique mode of replication. A virus consists of genetic material--either DNA or RNA--surrounded by a protein coat and, in some cases, by a membranous envelope.
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
A common parvovirus pathogen which causes largely asymptomatic infections in rats. KRV can be used to model environmental influences in the development of type 1 diabetes mellitus.
JSmith
2012-10-16T03:20:45Z
experimental_condition_ontology
KRV
XCO:0000238
Kilham rat virus
XCO:0000238
A common parvovirus pathogen which causes largely asymptomatic infections in rats. KRV can be used to model environmental influences in the development of type 1 diabetes mellitus.
PMID:19720792
http://www.criver.com/SiteCollectionDocuments/rm_ld_r_Rat_Parvoviruses.pdf
A chemical or biological substance which is capable of causing illness, debilitation or death, to living organisms, tissues or cells.
JSmith
2012-10-16T03:57:33Z
experimental_condition_ontology
poison
toxic chemical
XCO:0000239
toxic substance
XCO:0000239
A chemical or biological substance which is capable of causing illness, debilitation or death, to living organisms, tissues or cells.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
A protein or conjugated protein produced by some higher plants, certain animals, and pathogenic bacteria, that is highly poisonous for other living organisms.
JSmith
2012-10-16T04:07:55Z
experimental_condition_ontology
XCO:0000240
toxin
XCO:0000240
A protein or conjugated protein produced by some higher plants, certain animals, and pathogenic bacteria, that is highly poisonous for other living organisms.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is streptozotocin, a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. STZ can be used to treat pancreatic islet cell cancers and to model type 1 diabetes mellitus in animals via destruction of the insulin-producing beta cells of the islets of Langerhans.
JSmith
2012-10-16T04:09:16Z
CHEBI:9288
streptozocin
experimental_condition_ontology
STZ
XCO:0000241
streptozotocin
XCO:0000241
A condition in which the main influencing factor is streptozotocin, a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. STZ can be used to treat pancreatic islet cell cancers and to model type 1 diabetes mellitus in animals via destruction of the insulin-producing beta cells of the islets of Langerhans.
http://en.wikipedia.org/wiki/Streptozotocin
A condition in which the main influencing factor is alloxan, an oxygenated pyrimidine derivative which is toxic to the pancreatic insulin-producing beta cells of the islets of Langerhans in rodents and other animals and can therefore be used for modeling type 1 diabetes mellitus through destruction of the beta cells.
JSmith
2012-10-16T04:29:35Z
pubchem.compound:5781
2,4,5,6-pyrimidinetetrone
5-Oxobarbituric acid
alloxane
mesoxalylurea
experimental_condition_ontology
XCO:0000242
alloxan
XCO:0000242
A condition in which the main influencing factor is alloxan, an oxygenated pyrimidine derivative which is toxic to the pancreatic insulin-producing beta cells of the islets of Langerhans in rodents and other animals and can therefore be used for modeling type 1 diabetes mellitus through destruction of the beta cells.
http://en.wikipedia.org/wiki/Alloxan
Surgical removal of a portion of the pancreas, resulting in reduction but not elimination of the physiological functions of the pancreas.
JSmith
2012-10-16T04:49:10Z
experimental_condition_ontology
subtotal pancreatectomy
XCO:0000243
partial pancreatectomy
XCO:0000243
Surgical removal of a portion of the pancreas, resulting in reduction but not elimination of the physiological functions of the pancreas.
Gale:Gale_Encyclopedia_of_Medicine
A solid diet in which the amount of fructose, the monosaccharide found in honey and many sweet fruits which chemically combines with glucose to form the disaccharide sucrose, is maintained at a specified level.
JSmith
2012-10-16T05:00:17Z
experimental_condition_ontology
XCO:0000244
controlled fructose content diet
XCO:0000244
A solid diet in which the amount of fructose, the monosaccharide found in honey and many sweet fruits which chemically combines with glucose to form the disaccharide sucrose, is maintained at a specified level.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A protein hormone formed from proinsulin in the beta cells of the pancreatic islets of Langerhans. The major fuel-regulating hormone, it is secreted into the blood in response to a rise in concentration of blood glucose or amino acids. Insulin promotes the storage of glucose and the uptake of amino acids, increases protein and lipid synthesis, and inhibits lipolysis and gluconeogenesis.
JSmith
2012-10-16T05:04:48Z
experimental_condition_ontology
XCO:0000245
insulin
XCO:0000245
A protein hormone formed from proinsulin in the beta cells of the pancreatic islets of Langerhans. The major fuel-regulating hormone, it is secreted into the blood in response to a rise in concentration of blood glucose or amino acids. Insulin promotes the storage of glucose and the uptake of amino acids, increases protein and lipid synthesis, and inhibits lipolysis and gluconeogenesis.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A regimen of solid food in which the amount of cholesterol, a steroid alcohol found in animal fats and oils, is controlled.
JSmith
2012-11-30T15:42:17Z
experimental_condition_ontology
XCO:0000246
controlled cholesterol content diet
XCO:0000246
A regimen of solid food in which the amount of cholesterol, a steroid alcohol found in animal fats and oils, is controlled.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
A regimen of solid food to which a specified amount of olive oil has been added.
JSmith
2012-11-30T15:44:29Z
experimental_condition_ontology
XCO:0000247
controlled olive oil content diet
XCO:0000247
A regimen of solid food to which a specified amount of olive oil has been added.
RGD:JRS
A surgical procedure in which one or both kidneys from a donor organism are implanted into a recipient organism.
JSmith
2012-11-30T15:46:26Z
kidney transplantation
experimental_condition_ontology
XCO:0000248
kidney transplant
XCO:0000248
A surgical procedure in which one or both kidneys from a donor organism are implanted into a recipient organism.
Gale:Gale_Encyclopedia_of_Medicine
A surgical procedure in which the left kidney from a donor organism is implanted into a recipient organism.
JSmith
2012-11-30T15:51:17Z
experimental_condition_ontology
XCO:0000249
left kidney transplant
XCO:0000249
A surgical procedure in which the left kidney from a donor organism is implanted into a recipient organism.
Gale:Gale_Encyclopedia_of_Medicine
A surgical procedure in which the right kidney from a donor organism is implanted into a recipient organism.
JSmith
2012-11-30T15:53:04Z
experimental_condition_ontology
XCO:0000250
right kidney transplant
XCO:0000250
A surgical procedure in which the right kidney from a donor organism is implanted into a recipient organism.
Gale:Gale_Encyclopedia_of_Medicine
Any agent that induces exocrine, endocrine, or paracrine secretion.
JSmith
2012-11-30T15:55:11Z
experimental_condition_ontology
XCO:0000251
secretagogue
XCO:0000251
Any agent that induces exocrine, endocrine, or paracrine secretion.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A first generation potassium channel blocker and sulfonylurea oral hypoglycemic drug which stimulates the secretion of insulin by the pancreas.
JSmith
2012-11-30T15:56:41Z
experimental_condition_ontology
XCO:0000252
tolbutamide
XCO:0000252
A first generation potassium channel blocker and sulfonylurea oral hypoglycemic drug which stimulates the secretion of insulin by the pancreas.
http://en.wikipedia.org/wiki/Tolbutamide
This is any condition in which the main influencing factor is an ion of sodium, the chemical element with atomic number 11, that has lost one electron, forming a cation with a charge of +1.
JSmith
2013-02-28T13:11:25Z
CHEBI:29101
Na+ ion
experimental_condition_ontology
XCO:0000253
Not used for sodium salt in animal feed. For that application XCO:0000022, "controlled sodium content diet" is used.
sodium ion
XCO:0000253
This is any condition in which the main influencing factor is an ion of sodium, the chemical element with atomic number 11, that has lost one electron, forming a cation with a charge of +1.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2013-02-28T18:54:08Z
CHEBI:29101
Na+ ion solution
experimental_condition_ontology
XCO:0000254
sodium ion solution
XCO:0000254
A condition in which the main influencing factor is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
An immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with one or more components of the structure located between endothelial cells of renal capillaries and the visceral epithelial cells of the kidney glomerulus.
JSmith
2013-03-01T11:49:57Z
experimental_condition_ontology
anti-GBM antibody
nephritogenic monoclonal antibody b35
XCO:0000255
anti-glomerular basement membrane antibody
XCO:0000255
An immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with one or more components of the structure located between endothelial cells of renal capillaries and the visceral epithelial cells of the kidney glomerulus.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
A drug which is structurally similar to epinephrine and that binds to beta-adrenergic receptors to produce a physiologic reaction similar to or the same as that of epinephrine.
JSmith
2013-03-01T12:37:50Z
CHEBI:64317
isoprenaline
experimental_condition_ontology
XCO:0000256
isoproterenol
XCO:0000256
A drug which is structurally similar to epinephrine and that binds to beta-adrenergic receptors to produce a physiologic reaction similar to or the same as that of epinephrine.
http://en.wikipedia.org/wiki/Isoprenaline#Chemistry
A drink made up of water containing a specified amount of hydrogen ions, the chemical element with atomic number 1 that have lost one electron forming a cation with a charge of +1, for consumption by an organism in an experiment. Adjusting the amount of hydrogen ions adjusts the acidity, i.e. the pH of the drinking water.
JSmith
2013-03-01T16:10:48Z
experimental_condition_ontology
controlled acidity water
controlled pH water
water with adjusted pH
XCO:0000257
controlled hydrogen ion content drinking water
XCO:0000257
A drink made up of water containing a specified amount of hydrogen ions, the chemical element with atomic number 1 that have lost one electron forming a cation with a charge of +1, for consumption by an organism in an experiment. Adjusting the amount of hydrogen ions adjusts the acidity, i.e. the pH of the drinking water.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
Any phenomenon, chemical or biologic substance, or organism that exerts some force or effect resulting in a deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs.
JSmith
2013-03-01T16:24:26Z
disease inducing agent
experimental_condition_ontology
XCO:0000258
disease-inducing agent
XCO:0000258
Any phenomenon, chemical or biologic substance, or organism that exerts some force or effect resulting in a deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs.
Collins:Collins_Online_English_Dictionary
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules that exerts some force or effect resulting in a deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs.
JSmith
2013-03-01T16:30:57Z
disease inducing chemical
experimental_condition_ontology
XCO:0000259
disease-inducing chemical
XCO:0000259
A substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules that exerts some force or effect resulting in a deviation from or interruption of the normal structure or function of any body part, organ, or system that is manifested by a characteristic set of symptoms and signs.
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Collins:Collins_Online_English_Dictionary
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the major influencing factor is a peptide or protein, that is, any of a group of complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, capable of inducing a specific localized and/or systemic immune response.
JSmith
2013-03-01T16:46:02Z
antigenic protein
experimental_condition_ontology
XCO:0000260
peptide/protein antigen
XCO:0000260
A condition in which the major influencing factor is a peptide or protein, that is, any of a group of complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, capable of inducing a specific localized and/or systemic immune response.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
A substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules that, when administered, results in the inflammation of one or more joints, the sites of junction or union between bones, especially those that allow motion of the bones.
JSmith
2013-03-01T17:07:13Z
experimental_condition_ontology
XCO:0000261
arthritis inducing chemical
XCO:0000261
A substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules that, when administered, results in the inflammation of one or more joints, the sites of junction or union between bones, especially those that allow motion of the bones.
Collins:Collins_Online_English_Dictionary
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the major influencing factor is any of a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility; composed of molecules of tropocollagen.
JSmith
2013-03-01T17:35:20Z
experimental_condition_ontology
XCO:0000262
collagen
XCO:0000262
A condition in which the major influencing factor is any of a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility; composed of molecules of tropocollagen.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the major influencing factor is an acyclic saturated hydrocarbon derived from phytane by loss of its C-16 terminal methyl group.
JSmith
2013-03-01T17:39:39Z
CHEBI:53181
MESH:C009042
2,6,10,14-tetramethylpentadecane
experimental_condition_ontology
XCO:0000263
pristane
XCO:0000263
A nonspecific stimulator of the immune response consisting of non-metabolizable oils used to make water-in-oil emulsions with specific antigens. The adjuvant increases the strength of the immune response.
JSmith
2013-03-01T18:05:06Z
experimental_condition_ontology
XCO:0000264
Freund's adjuvant
XCO:0000264
A nonspecific stimulator of the immune response consisting of non-metabolizable oils used to make water-in-oil emulsions with specific antigens. The adjuvant increases the strength of the immune response.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
https://www.invivogen.com/ifa
IFA is used to make a water-in-oil antigen-containing emulsion that lacks the Mycobacteria found in Complete Freund′s Adjuvant so it minimizes the side-effects. It is routinely used for boosting immunizations subsequent to use of Freund's complete adjuvant.
JSmith
2013-03-01T18:07:25Z
experimental_condition_ontology
FIA
IFA
XCO:0000265
Freund's incomplete adjuvant
XCO:0000265
IFA is used to make a water-in-oil antigen-containing emulsion that lacks the Mycobacteria found in Complete Freund′s Adjuvant so it minimizes the side-effects. It is routinely used for boosting immunizations subsequent to use of Freund's complete adjuvant.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
https://www.sigmaaldrich.com/catalog/product/sigma/f5506?lang=en®ion=US
A water-in-oil emulsion incorporating antigen in the aqueous phase, and killed, dried mycobacteria, e.g., Mycobacterium butyricum in lightweight paraffin oil. A suspension is achieved with the aid of an emulsifying agent. The mixture induces both cell-mediated immunity (delayed hypersensitivity), and humoral antibody formation.
JSmith
2013-03-01T18:10:14Z
experimental_condition_ontology
CFA
FCA
XCO:0000266
Freund's complete adjuvant
XCO:0000266
A water-in-oil emulsion incorporating antigen in the aqueous phase, and killed, dried mycobacteria, e.g., Mycobacterium butyricum in lightweight paraffin oil. A suspension is achieved with the aid of an emulsifying agent. The mixture induces both cell-mediated immunity (delayed hypersensitivity), and humoral antibody formation.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the major influencing factor is a polymer found in the cell walls of prokaryotes that consists of polysaccharide and peptide chains in a strong molecular network.
JSmith
2013-03-11T15:53:57Z
CHEBI:8005
experimental_condition_ontology
PG-PS
XCO:0000267
peptidoglycan-polysaccharide
XCO:0000267
A condition in which the major influencing factor is a polymer found in the cell walls of prokaryotes that consists of polysaccharide and peptide chains in a strong molecular network.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
A technique of mechanically widening narrowed or obstructed arteries by use of a soft catheter with an inflatable tip.
JSmith
2013-03-11T16:14:44Z
experimental_condition_ontology
XCO:0000268
balloon angioplasty
XCO:0000268
A technique of mechanically widening narrowed or obstructed arteries by use of a soft catheter with an inflatable tip.
http://en.wikipedia.org/wiki/Balloon_angioplasty
This is any condition in which the main influencing factor is any chemical substance which decreases or interferes with the activity of a calcium channel, one or more membrane-bound globular proteins that display selective permeability to calcium ions, the chemical element with atomic number 20 that has lost two electrons forming a cation with a charge of +2, and allow diffusion of these ions across a cell membrane.
JSmith
2013-03-11T16:37:02Z
calcium channel blocker
experimental_condition_ontology
XCO:0000269
calcium channel inhibitor
XCO:0000269
This is any condition in which the main influencing factor is any chemical substance which decreases or interferes with the activity of a calcium channel, one or more membrane-bound globular proteins that display selective permeability to calcium ions, the chemical element with atomic number 20 that has lost two electrons forming a cation with a charge of +2, and allow diffusion of these ions across a cell membrane.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A sulfur-containing carboxylic acid with a pyrrolidine substituent at C-1, which decreases or interferes with the activity of angiotensin converting enzyme (ACE) inhibitor, used as an anti-hypertensive drug.
JSmith
2013-03-11T16:51:57Z
CHEBI:3380
experimental_condition_ontology
XCO:0000270
captopril
XCO:0000270
A sulfur-containing carboxylic acid with a pyrrolidine substituent at C-1, which decreases or interferes with the activity of angiotensin converting enzyme (ACE) inhibitor, used as an anti-hypertensive drug.
http://en.wikipedia.org/wiki/Captopril
A substance that opposes oxidation, a reaction in which the atoms in an element lose electrons, and/or inhibits reactions brought about by dioxygen or peroxides.
JSmith
2013-03-12T11:01:04Z
antioxydant
antoxidant
experimental_condition_ontology
XCO:0000271
antioxidant
XCO:0000271
A substance that opposes oxidation, a reaction in which the atoms in an element lose electrons, and/or inhibits reactions brought about by dioxygen or peroxides.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
CHEBI:22586
A heterocyclic compound used as an agent for detoxifying reactive oxygen species. It catalyses the disproportionation of superoxide.
JSmith
2013-03-12T11:09:12Z
pubchem.compound:137994
experimental_condition_ontology
4-Oxypiperidol
4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl
HyTEMPO
Nitroxyl-2
TMPN
Tanol
XCO:0000272
tempol
XCO:0000272
A heterocyclic compound used as an agent for detoxifying reactive oxygen species. It catalyses the disproportionation of superoxide.
http://en.wikipedia.org/wiki/4-Hydroxy-TEMPO
A family of linear, sulfated, high-molecular-weight polysaccharides made up of repeating galactose and 3,6-anhydrogalactose units with alternating alpha 1-3 and beta 1-4 glycosidic linkages.
JSmith
2013-03-12T13:07:06Z
CHEBI:3435
experimental_condition_ontology
XCO:0000273
carrageenan
XCO:0000273
A family of linear, sulfated, high-molecular-weight polysaccharides made up of repeating galactose and 3,6-anhydrogalactose units with alternating alpha 1-3 and beta 1-4 glycosidic linkages.
http://en.wikipedia.org/wiki/Carrageenan
Any simple carbohydrate consisting of a single basic sugar unit with the general formula Cn(H2O)n, with n ranging from 3 to 8.
JSmith
2013-03-12T13:10:01Z
experimental_condition_ontology
XCO:0000274
monosaccharide
XCO:0000274
Any simple carbohydrate consisting of a single basic sugar unit with the general formula Cn(H2O)n, with n ranging from 3 to 8.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues. It is one of the three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion, is the end product of carbohydrate metabolism, and is the chief source of energy for living organisms.
JSmith
2013-03-12T13:28:39Z
dextrose
experimental_condition_ontology
XCO:0000275
glucose
XCO:0000275
A monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues. It is one of the three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion, is the end product of carbohydrate metabolism, and is the chief source of energy for living organisms.
http://www.thefreedictionary.com/
Any of a large group of organic compounds whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12.
JSmith
2013-03-12T16:18:50Z
experimental_condition_ontology
XCO:0000276
hydrocarbon
XCO:0000276
Any of a large group of organic compounds whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form a continuous or closed chain linked by bonds that may be represented graphically by one or more circular or triangular forms.
JSmith
2013-03-12T17:18:43Z
experimental_condition_ontology
XCO:0000277
cyclic hydrocarbon
XCO:0000277
Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form a continuous or closed chain linked by bonds that may be represented graphically by one or more circular or triangular forms.
http://www.thefreedictionary.com/
Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form continuous or closed chains linked by bonds that may be represented graphically by multiple interlinking circular or triangular forms.
JSmith
2013-03-12T17:20:06Z
experimental_condition_ontology
XCO:0000278
polycyclic hydrocarbon
XCO:0000278
Any organic compound whose molecules are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, and whose carbon atoms form continuous or closed chains linked by bonds that may be represented graphically by multiple interlinking circular or triangular forms.
http://www.thefreedictionary.com/
Any of a large and diverse class of organic compounds which are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, which are derived biosynthetically from units of isoprene and which have the general molecular formula (CH2=C(CH3)CH=CH2)n where n is the number of linked isoprene units.
JSmith
2013-03-12T17:24:22Z
experimental_condition_ontology
XCO:0000279
terpene
XCO:0000279
Any of a large and diverse class of organic compounds which are composed only of hydrogen, the element with atomic number 1, and carbon, the element with atomic number 12, which are derived biosynthetically from units of isoprene and which have the general molecular formula (CH2=C(CH3)CH=CH2)n where n is the number of linked isoprene units.
http://en.wikipedia.org/wiki/Terpene
A triterpene, that is a terpine containing six isoprene units, consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration. Squalene is the biochemical precursor to steroids.
JSmith
2013-03-12T17:25:17Z
CHEBI:15440
MESH:D013185
experimental_condition_ontology
Spinacene
Supraene
XCO:0000280
squalene
XCO:0000280
A triterpene, that is a terpine containing six isoprene units, consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration. Squalene is the biochemical precursor to steroids.
http://en.wikipedia.org/wiki/Squalene
A condition in which the major influencing factor is the fibrillar collagen which comprises the main component of cartilage and is also found in the vitreous humor of the eye. Collagens are a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility.
JSmith
2013-03-12T17:41:57Z
type 2 collagen
experimental_condition_ontology
XCO:0000281
type II collagen
XCO:0000281
A condition in which the major influencing factor is the fibrillar collagen which comprises the main component of cartilage and is also found in the vitreous humor of the eye. Collagens are a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Collagen
An immunoglobulin molecule having a specific amino acid sequence that gives it the ability to adhere to and interact only with Thy1, i.e. Thymocyte antigen 1, and molecules containing structures similar to that antigen. Thy1, also known as CD90, is a 25-37 kDa, heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored, conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen and now known to be the smallest member of the immunoglobulin superfamily of proteins.
JSmith
2013-03-12T18:06:13Z
anti-CD90 antibody
experimental_condition_ontology
XCO:0000282
anti-Thy1 antibody
XCO:0000282
An immunoglobulin molecule having a specific amino acid sequence that gives it the ability to adhere to and interact only with Thy1, i.e. Thymocyte antigen 1, and molecules containing structures similar to that antigen. Thy1, also known as CD90, is a 25-37 kDa, heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored, conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen and now known to be the smallest member of the immunoglobulin superfamily of proteins.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
http://en.wikipedia.org/wiki/CD90
Exposure to visible light in a manner, such as for a length of time or at a level, which would not be considered natural, usual or environmental and which is designed to elicit or evoke an action or response in a cell, an excitable tissue, or an organism.
JSmith
2013-03-13T12:03:39Z
light therapy
phototherapy
experimental_condition_ontology
XCO:0000283
visible light stimulus
XCO:0000283
Exposure to visible light in a manner, such as for a length of time or at a level, which would not be considered natural, usual or environmental and which is designed to elicit or evoke an action or response in a cell, an excitable tissue, or an organism.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
Condition during which a subject or sample is directly in the presence of or influenced by visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, at a constrained level and/or for a constrained period of time.
JSmith
2013-03-13T12:12:45Z
experimental_condition_ontology
XCO:0000284
controlled visible light exposure
XCO:0000284
Condition during which a subject or sample is directly in the presence of or influenced by visible light, that is, electromagnetic radiation with wavelengths between approximately 390 (violet) and 770 (red) nanometers, capable of stimulating the subjective sensation of sight, at a constrained level and/or for a constrained period of time.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
A drink made up of water and a specified amount of the basic amino acid commonly known as L-NAME and used as a non-selective inhibitor of nitric oxide synthase, consumed by an organism as part of an experiment.
JSmith
2013-03-13T14:48:31Z
controlled L-NAME content drinking water
experimental_condition_ontology
XCO:0000285
controlled NG-nitroarginine methyl ester content drinking water
XCO:0000285
A drink made up of water and a specified amount of the basic amino acid commonly known as L-NAME and used as a non-selective inhibitor of nitric oxide synthase, consumed by an organism as part of an experiment.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
MESH:D019331
A condition in which the major influencing factor is a highly antigenic, soluble photoreceptor protein expressed in the retina and the pineal gland and involved in desensitization of the photoactivated transduction cascade.
JSmith
2013-03-13T17:02:20Z
arrestin
experimental_condition_ontology
HSAg
S-antigen
S-antigen peptide
S-arrestin
SAG
retinal soluble antigen
XCO:0000286
retinal S-antigen
XCO:0000286
A condition in which the major influencing factor is a highly antigenic, soluble photoreceptor protein expressed in the retina and the pineal gland and involved in desensitization of the photoactivated transduction cascade.
NCBI_GeneID:6295
A condition in which the major influencing factor is a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors.
JSmith
2013-03-13T17:19:56Z
interphotoreceptor retinol-binding protein
retinol binding protein 3, interstitial
experimental_condition_ontology
IRBP
Rbp3
XCO:0000287
interphotoreceptor retinoid-binding protein
XCO:0000287
A condition in which the major influencing factor is a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors.
NCBI_GeneID:5949
A condition in which the major influencing factor is a 15 amino acid peptide (aa 1177-1191) derived from the interphotoreceptor retinoid-binding protein, a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors.
JSmith
2013-03-13T17:55:10Z
PMID:10323205
experimental_condition_ontology
R16 peptide of IRBP
XCO:0000288
R16 peptide of interphotoreceptor retinoid-binding protein
XCO:0000288
A condition in which the major influencing factor is a 15 amino acid peptide (aa 1177-1191) derived from the interphotoreceptor retinoid-binding protein, a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors.
NCBI_GeneID:5949
A condition in which the major influencing factor is a 23 amino acid peptide (aa 1169-1191) derived from the interphotoreceptor retinoid-binding protein, a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors.
JSmith
2013-03-13T17:56:51Z
PMID:18203685
experimental_condition_ontology
R14 peptide of IRBP
XCO:0000289
R14 peptide of interphotoreceptor retinoid-binding protein
XCO:0000289
A condition in which the major influencing factor is a 23 amino acid peptide (aa 1169-1191) derived from the interphotoreceptor retinoid-binding protein, a large glycoprotein, found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells, which is known to bind retinoids and thought to transport them between the retinal pigment epithelium and the photoreceptors.
NCBI_GeneID:5949
A condition in which the major influencing factor is a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins.
JSmith
2013-03-13T18:21:29Z
RGD:1585218
myelin P2 protein
experimental_condition_ontology
Pmp2
XCO:0000290
peripheral myelin protein 2
XCO:0000290
A condition in which the major influencing factor is a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins.
UniProtKB:P02689
A condition in which the major influencing factor is the peptide (KNTEISFKLGQEFEETTADNRKTK) representing residues 58 to 81 of peripheral myelin protein 2, a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins.
JSmith
2013-03-13T18:44:21Z
experimental_condition_ontology
P2 58-81
P2 peptide 58-81
XCO:0000291
peripheral myelin protein 2 peptide 58-81
XCO:0000291
A condition in which the major influencing factor is the peptide (KNTEISFKLGQEFEETTADNRKTK) representing residues 58 to 81 of peripheral myelin protein 2, a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins.
RGD:2306736
UniProtKB:P02689
A condition in which the major influencing factor is peripheral nerve myelin, a lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the axons of peripheral nerves, that is, nerves that are not part of either the brain or spinal cord of the organism.
JSmith
2013-03-13T19:18:05Z
experimental_condition_ontology
PNM
PNS myelin
peripheral nervous system myelin
XCO:0000292
peripheral nerve myelin
XCO:0000292
A condition in which the major influencing factor is peripheral nerve myelin, a lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the axons of peripheral nerves, that is, nerves that are not part of either the brain or spinal cord of the organism.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A coordination complex of technetium-99m, a radioisotope of the chemical element technetium, atomic number 43, a gamma emitter having a half-life of approximately 6 hours, and methoxyisobutylisonitrile (MIBI), a lipophilic cation, used as an agent in nuclear medicine imaging.
JSmith
2013-03-13T20:07:09Z
CHEBI:33371
experimental_condition_ontology
99mTc-hexakis-2-methoxy-2-methylpropyl isonitrile
Cardiolite
MIBI
XCO:0000293
99mTc-sestamibi
XCO:0000293
A coordination complex of technetium-99m, a radioisotope of the chemical element technetium, atomic number 43, a gamma emitter having a half-life of approximately 6 hours, and methoxyisobutylisonitrile (MIBI), a lipophilic cation, used as an agent in nuclear medicine imaging.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Technetium_%2899mTc%29_sestamibi
Any of the naturally-occuring, primary female sex hormones or related synthetic molecules with the capacity to perform the same function(s), i.e. to bind to estrogen receptors and stimulate or control the development and maintenance of female sex characteristics.
JSmith
2013-05-07T15:32:52Z
CHEBI:50114
experimental_condition_ontology
Not4Curation
XCO:0000294
estrogen/estrogen analog
XCO:0000294
Any of the naturally-occuring, primary female sex hormones or related synthetic molecules with the capacity to perform the same function(s), i.e. to bind to estrogen receptors and stimulate or control the development and maintenance of female sex characteristics.
http://en.wikipedia.org/wiki/Estrogen
A synthetic estrogen analog with chemical formula C18H20O2. The structure is similar to that of estrogen but lacks the complete four ring structure. As a drug it is used to treat prostatic and sometimes breast carcinomas. It is an epigenetic carcinogen.
JSmith
2013-05-07T16:01:13Z
CHEBI:41922
experimental_condition_ontology
DES
XCO:0000295
diethylstilbestrol
XCO:0000295
A synthetic estrogen analog with chemical formula C18H20O2. The structure is similar to that of estrogen but lacks the complete four ring structure. As a drug it is used to treat prostatic and sometimes breast carcinomas. It is an epigenetic carcinogen.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Diethylstilbestrol
The act of rapidly moving the feet on an exercise apparatus with an endless belt that allows the user to perform the action of running in place and that is maintained at an angle which deviates from the horozontal by a specified amount.
JSmith
2013-06-07T16:08:44Z
running on sloped treadmill
experimental_condition_ontology
XCO:0000296
running on inclined treadmill
XCO:0000296
The act of rapidly moving the feet on an exercise apparatus with an endless belt that allows the user to perform the action of running in place and that is maintained at an angle which deviates from the horozontal by a specified amount.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
Encarta:Encarta_World_English_Dictionary
Condition in which liquids for drinking (bringing a liquid into the mouth and swallowing it to quench thirst, for nourishment, etc.), such as water, are withheld for a specified period of time.
JSmith
2013-06-11T09:50:38Z
water deprivation
experimental_condition_ontology
XCO:0000297
fluid deprivation
XCO:0000297
Condition in which liquids for drinking (bringing a liquid into the mouth and swallowing it to quench thirst, for nourishment, etc.), such as water, are withheld for a specified period of time.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
http://www.yourdictionary.com/drink
Water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O) supplied as a drink, that is, as a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., in which the amount of saccharin, a cyclic imine of 2-sulfobenzoic acid which is 500 times sweeter than sugar and used as a nonnutritive sweetener, is adjusted to a requirement.
JSmith
2013-06-11T10:05:25Z
experimental_condition_ontology
XCO:0000298
controlled saccharin content drinking water
XCO:0000298
Water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O) supplied as a drink, that is, as a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., in which the amount of saccharin, a cyclic imine of 2-sulfobenzoic acid which is 500 times sweeter than sugar and used as a nonnutritive sweetener, is adjusted to a requirement.
http://www.thefreedictionary.com/
Condition in which a drink, that is, a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, is supplied as the only available drink option for consumption by an organism in an experiment.
JSmith
2013-06-11T10:06:43Z
experimental_condition_ontology
XCO:0000299
controlled ethanol content drinking water with no other optional drink source
XCO:0000299
Condition in which a drink, that is, a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, is supplied as the only available drink option for consumption by an organism in an experiment.
http://www.thefreedictionary.com/
Condition in which a drink, that is, a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, is supplied along with additive-free water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O), as an additional drink option for consumption by an organism in an experiment.
JSmith
2013-06-11T10:07:22Z
experimental_condition_ontology
XCO:0000300
controlled ethanol content drinking water with water as an optional drink source
XCO:0000300
Condition in which a drink, that is, a liquid to be brought into the mouth and swallowed to quench thirst, for nourishment, etc., made up of water and a specified amount of ethanol, the alcohol with chemical formula CH3-CH2-OH obtained from the fermentation of sugars and starches or by chemical synthesis which is the intoxicating ingredient of alcoholic beverages, is supplied along with additive-free water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O), as an additional drink option for consumption by an organism in an experiment.
http://www.thefreedictionary.com/
A condition in which the main influencing factor is a homogeneous mixture of atoms of lithium, the chemical element with atomic number 3, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2013-06-11T10:08:36Z
CHEBI:49713
experimental_condition_ontology
XCO:0000301
lithium ion solution
XCO:0000301
A condition in which the main influencing factor is a homogeneous mixture of atoms of lithium, the chemical element with atomic number 3, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is a homogeneous mixture of atoms of lithium, the chemical element with atomic number 3, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2013-06-11T10:09:05Z
CHEBI:48607
experimental_condition_ontology
XCO:0000302
lithium chloride solution
XCO:0000302
A condition in which the main influencing factor is a homogeneous mixture of atoms of lithium, the chemical element with atomic number 3, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
The surgical excision of one or both of the adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
JSmith
2013-06-20T17:37:01Z
suprarenalectomy
experimental_condition_ontology
XCO:0000303
adrenalectomy
XCO:0000303
The surgical excision of one or both of the adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
The surgical excision of both adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
JSmith
2013-06-20T17:49:29Z
bilateral suprarenalectomy
experimental_condition_ontology
XCO:0000304
bilateral adrenalectomy
XCO:0000304
The surgical excision of both adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
The surgical excision of only one of the adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
JSmith
2013-06-20T17:50:15Z
unilateral suprarenalectomy
experimental_condition_ontology
XCO:0000305
unilateral adrenalectomy
XCO:0000305
The surgical excision of only one of the adrenal glands, two small, dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
An activity or condition which involves subjecting all or part of an organism to a relatively low, i.e., lower than considered normal, temperature.
JSmith
2013-06-21T16:31:04Z
experimental_condition_ontology
XCO:0000306
cold exposure
XCO:0000306
An activity or condition which involves subjecting all or part of an organism to a relatively low, i.e., lower than considered normal, temperature.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
An activity or condition in which the air surrounding or encircling the organism has a relatively low, or lower than considered normal, temperature, i.e., air in which the molecules possess a lower than normal amount of random kinetic energy.
JSmith
2013-06-21T16:52:48Z
cold exposure, ambient air
experimental_condition_ontology
cold stress
XCO:0000307
cold ambient air exposure
XCO:0000307
An activity or condition in which the air surrounding or encircling the organism has a relatively low, or lower than considered normal, temperature, i.e., air in which the molecules possess a lower than normal amount of random kinetic energy.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
An activity or condition which involves subjecting all or part of an organism to a relatively high, or higher than considered normal, temperature, that is, possessing a higher than normal level of random kinetic energy of atoms, molecules, or ions.
JSmith
2013-06-21T17:12:21Z
experimental_condition_ontology
XCO:0000308
heat exposure
XCO:0000308
An activity or condition which involves subjecting all or part of an organism to a relatively high, or higher than considered normal, temperature, that is, possessing a higher than normal level of random kinetic energy of atoms, molecules, or ions.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
An activity or condition in which the air surrounding or encircling the organism has a relatively high, or higher than considered normal, temperature, i.e., air in which the molecules possess a higher than normal amount of random kinetic energy.
JSmith
2013-06-21T17:21:42Z
heat exposure, ambient air
experimental_condition_ontology
hot ambient air exposure
warm ambient air exposure
XCO:0000309
heated ambient air exposure
XCO:0000309
An activity or condition in which the air surrounding or encircling the organism has a relatively high, or higher than considered normal, temperature, i.e., air in which the molecules possess a higher than normal amount of random kinetic energy.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
An antihypertensive agent that acts by selectively inhibiting transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. It does not appear to act at the level of the adrenergic receptors.
JSmith
2013-06-21T18:45:16Z
CHEBI:5557
MESH:D006145
experimental_condition_ontology
XCO:0000310
guanethidine
XCO:0000310
An antihypertensive agent that acts by selectively inhibiting transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. It does not appear to act at the level of the adrenergic receptors.
http://www.drugbank.ca/drugs/DB01170#pharmacology
A condition in which the main influencing factor is a homogeneous mixture of atoms of potassium, the chemical element with atomic number 19, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2013-06-25T14:02:51Z
CHEBI:29103
K+ ion solution
experimental_condition_ontology
XCO:0000311
potassium ion solution
XCO:0000311
A condition in which the main influencing factor is a homogeneous mixture of atoms of potassium, the chemical element with atomic number 19, that have lost one electron, forming a cation with a charge of +1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is a homogeneous mixture of atoms of potassium, the chemical element with atomic number 19, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2013-06-25T14:06:24Z
CHEBI:32588
KCl solution
experimental_condition_ontology
XCO:0000312
potassium chloride solution
XCO:0000312
A condition in which the main influencing factor is a homogeneous mixture of atoms of potassium, the chemical element with atomic number 19, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is an atom of lithium, the chemical element with atomic number 3, that has lost one electron, forming a cation with a charge of +1.
JSmith
2013-06-25T14:24:21Z
CHEBI:49713
Li+ ion
experimental_condition_ontology
XCO:0000313
lithium ion
XCO:0000313
A condition in which the main influencing factor is an atom of lithium, the chemical element with atomic number 3, that has lost one electron, forming a cation with a charge of +1.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base.
JSmith
2013-06-25T14:52:26Z
CHEBI:35225
experimental_condition_ontology
XCO:0000314
buffer
XCO:0000314
A homogeneous mixture of molecules, atoms and/or ions, one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2013-06-25T14:58:18Z
CHEBI:35225
experimental_condition_ontology
XCO:0000315
buffer solution
XCO:0000315
A homogeneous mixture of molecules, atoms and/or ions, one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A homogeneous mixture which does not contain calcium, the chemical element with atomic number 20, but does contain molecules, atoms and/or ions one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2013-06-25T15:06:57Z
CHEBI:35225
experimental_condition_ontology
XCO:0000316
calcium-free buffer solution
XCO:0000316
A homogeneous mixture which does not contain calcium, the chemical element with atomic number 20, but does contain molecules, atoms and/or ions one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A homogeneous mixture of calcium, the chemical element with atomic number 20, with other molecules, atoms and/or ions one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2013-06-25T15:13:18Z
CHEBI:29108
CHEBI:35225
calcium-containing buffer solution
experimental_condition_ontology
XCO:0000317
buffered calcium ion solution
XCO:0000317
A homogeneous mixture of calcium, the chemical element with atomic number 20, with other molecules, atoms and/or ions one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A process in which manual and instrumental techniques are used to assemble or combine parts or substances, especially in order to create something new.
JSmith
2013-06-25T16:06:11Z
experimental_condition_ontology
XCO:0000318
surgical construction
XCO:0000318
A process in which manual and instrumental techniques are used to assemble or combine parts or substances, especially in order to create something new.
Cambridge:Cambridge_Online_Dictionary_of_American_English
Collins:Collins_Online_English_Dictionary
http://en.wikipedia.org/wiki/Surgery
A surgically created passageway between the abdominal aorta and inferior vena cava.
JSmith
2013-06-25T16:08:47Z
PMID:2142618
experimental_condition_ontology
ACF
XCO:0000319
artificial aortocaval fistula
XCO:0000319
A surgically created passageway between the abdominal aorta and inferior vena cava.
ISBN-13:978-0781733908
Either of two compounds (C12H30Br2N2 or C12H30Cl2N2) used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself.
JSmith
2013-06-25T17:12:45Z
CHEBI:5700
CID:3604
MESH:D018738
Benzohexamethonium
hexamethone
hexathonide
experimental_condition_ontology
XCO:0000320
hexamethonium
XCO:0000320
Either of two compounds (C12H30Br2N2 or C12H30Cl2N2) used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
http://en.wikipedia.org/wiki/Hexamethonium
The compound C12H30Br2N2, consisting of a hexamethonium cation and dibromide anion, used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself.
JSmith
2013-06-25T17:17:10Z
chembl.compound:CHEMBL105608
pubchem.compound:5938
experimental_condition_ontology
hexamethonium dibromide
XCO:0000321
hexamethonium bromide
XCO:0000321
The compound C12H30Br2N2, consisting of a hexamethonium cation and dibromide anion, used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
http://en.wikipedia.org/wiki/Hexamethonium
The compound C12H30Cl2N2, consisting of a hexamethonium cation and dichloride anion, used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself.
JSmith
2013-06-25T17:19:38Z
CHEMBL:105608
CID:93550
experimental_condition_ontology
hexamethonium dichloride
XCO:0000322
hexamethonium chloride
XCO:0000322
The compound C12H30Cl2N2, consisting of a hexamethonium cation and dichloride anion, used in the treatment of hypertension. Hexamethonium is a depolarising ganglionic blocker, a nicotinic acetylcholine receptor antagonist that acts in autonomic ganglia by binding in or on the receptor but not the acetylcholine binding site itself.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
http://en.wikipedia.org/wiki/Hexamethonium
Any condition in which the main influencing factor is an alcohol, a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.
JSmith
2013-08-07T16:27:07Z
CHEBI:30879
experimental_condition_ontology
XCO:0000323
alcohol
XCO:0000323
Any condition in which the main influencing factor is a primary alcohol, a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
JSmith
2013-08-07T16:35:17Z
CHEBI:15734
experimental_condition_ontology
XCO:0000324
primary alcohol
XCO:0000324
Any condition in which the main influencing factor is ethanol, a primary alcohol with chemical formula CH3-CH2-OH, that is ethane in which one of the hydrogens is substituted by a hydroxy group.
JSmith
2013-08-07T16:39:26Z
CHEBI:16236
ethyl alcohol
experimental_condition_ontology
EtOH
XCO:0000325
ethanol
XCO:0000325
Any condition in which the main influencing factor is ethanol, the colorless, volatile, flammable liquid, CH3CH2OH, produced by yeast fermentation of carbohydrates or synthesized by hydration of ethylene, suspended in a saline solution, a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
JSmith
2013-08-07T16:45:26Z
ethanol in saline
ethanol in 0.9 % saline
ethanol in 0.9 % saline solution
experimental_condition_ontology
XCO:0000326
controlled ethanol content saline
XCO:0000326
Any condition in which the main influencing factor is ethanol, the colorless, volatile, flammable liquid, CH3CH2OH, produced by yeast fermentation of carbohydrates or synthesized by hydration of ethylene, suspended in a saline solution, a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Webster:Random_House_Kernerman_Websters_College_Dictionary_2010
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of quinine, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Quinine is a bitter alkaloid of cinchona that has antimalarial, analgesic, antipyretic, mild oxytocic, cardiac depressant, and sclerosing properties, and that decreases the excitability of the motor end plate.
JSmith
2013-08-07T17:05:17Z
experimental_condition_ontology
XCO:0000327
controlled quinine content drinking water
XCO:0000327
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of quinine, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Quinine is a bitter alkaloid of cinchona that has antimalarial, analgesic, antipyretic, mild oxytocic, cardiac depressant, and sclerosing properties, and that decreases the excitability of the motor end plate.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://www.yourdictionary.com/drink
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of deoxycorticosterone, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.
jsmith
2013-08-22T12:58:04Z
experimental_condition_ontology
controlled DOC content drinking water
XCO:0000328
controlled deoxycorticosterone content drinking water
XCO:0000328
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of deoxycorticosterone, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/11-Deoxycorticosterone
http://www.yourdictionary.com/drink
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of saline and a specified amount of deoxycorticosterone, and consumed by an organism as part of an experiment. Saline is a homogeneous mixture of sodium chloride (i.e. atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1) dispersed molecularly in a sufficient and specified quantity of dissolving medium (solvent) such as water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.
jsmith
2013-08-22T13:00:11Z
CHEBI:16973
experimental_condition_ontology
controlled DOC and sodium chloride content drinking water
controlled DOC content saline drink
controlled deoxycorticosterone and sodium content drinking water
XCO:0000329
controlled deoxycorticosterone content saline drink
XCO:0000329
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of saline and a specified amount of deoxycorticosterone, and consumed by an organism as part of an experiment. Saline is a homogeneous mixture of sodium chloride (i.e. atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1) dispersed molecularly in a sufficient and specified quantity of dissolving medium (solvent) such as water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/11-Deoxycorticosterone
http://www.yourdictionary.com/drink
Any condition in which the main influencing factor is deoxycorticosterone, a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone, or a derivative of that hormone.
jsmith
2013-08-22T14:38:17Z
experimental_condition_ontology
DOC
XCO:0000330
deoxycorticosterone
XCO:0000330
Any condition in which the main influencing factor is deoxycorticosterone, a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone, or a derivative of that hormone.
http://en.wikipedia.org/wiki/11-Deoxycorticosterone
Any condition in which the main influencing factor is RU28362, a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor.
jsmith
2013-08-22T14:49:55Z
pubchem.compound:123790
11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one
experimental_condition_ontology
XCO:0000331
RU28362
XCO:0000331
Any condition in which the main influencing factor is RU28362, a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor.
http://en.wikipedia.org/wiki/RU28362
http://www.nursa.org/molecule.cfm?molType=ligand&molId=1123
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of RU28362, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). RU28362 is a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor.
jsmith
2013-08-22T15:03:35Z
experimental_condition_ontology
XCO:0000332
controlled RU28362 content drinking water
XCO:0000332
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of RU28362, and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). RU28362 is a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor.
ISBN:978-1416049982
http://en.wikipedia.org/wiki/RU28362
http://www.nursa.org/molecule.cfm?molType=ligand&molId=1123
http://www.thefreedictionary.com/
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of saline and a specified amount of RU28362, and consumed by an organism as part of an experiment. Saline is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient and specified quantity of dissolving medium (solvent) such as water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). RU28362 is a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor.
jsmith
2013-08-22T15:06:01Z
experimental_condition_ontology
controlled RU28362 and sodium chloride content drinking water
XCO:0000333
controlled RU28362 content saline drink
XCO:0000333
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of saline and a specified amount of RU28362, and consumed by an organism as part of an experiment. Saline is a homogeneous mixture of atoms of sodium, the chemical element with atomic number 11, that have lost one electron forming a cation with a charge of +1, and an equivalent number of atoms of chlorine, the chemical element with atomic number 17, that have gained one electron forming an anion with a charge of -1 dispersed molecularly in a sufficient and specified quantity of dissolving medium (solvent) such as water, the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). RU28362 is a highly selective neuroactive agonist of the glucocorticoid (Corticoid Type II) receptor, but not of the mineralocorticoid (Corticoid Type I) receptor.
ISBN:978-1416049982
http://en.wikipedia.org/wiki/RU28362
http://www.nursa.org/molecule.cfm?molType=ligand&molId=1123
http://www.thefreedictionary.com/
The surgical excision of only the adrenal gland on the left side of the body. The left adrenal gland is generally the larger of the two dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
jsmith
2013-08-22T15:48:28Z
left suprarenalectomy
left unilateral adrenalectomy
left unilateral suprarenalectomy
experimental_condition_ontology
XCO:0000334
Note that "left" in this context refers to the perspective of the organism, not that of the observer. (Wikipedia: Anatomical_terms_of_location).
left adrenalectomy
XCO:0000334
The surgical excision of only the adrenal gland on the left side of the body. The left adrenal gland is generally the larger of the two dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
http://en.wikipedia.org/wiki/Adrenal_gland
The surgical excision of only the adrenal gland on the right side of the body. The right adrenal gland is generally the smaller of the two dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
jsmith
2013-08-22T15:50:50Z
right suprarenalectomy
right unilateral adrenalectomy
right unilateral suprarenalectomy
experimental_condition_ontology
XCO:0000335
Note that "right" in this context refers to the perspective of the organism, not that of the observer. (Wikipedia: Anatomical_terms_of_location).
right adrenalectomy
XCO:0000335
The surgical excision of only the adrenal gland on the right side of the body. The right adrenal gland is generally the smaller of the two dissimilarly shaped endocrine glands, one located above each kidney, consisting of the cortex, which secretes several steroid hormones, and the medulla, which secretes epinephrine.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
http://en.wikipedia.org/wiki/Adrenal_gland
Any condition in which the main influencing factor is an agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists, substances that have an affinity for and stimulate physiologic activity at adrenergic receptors. Adrenergic receptors are a class of G protein-coupled receptors that are targets of catecholamines, especially norepinephrine and epinephrine.
jsmith
2013-08-22T16:22:29Z
adrenergic receptor antagonist
experimental_condition_ontology
XCO:0000336
adrenergic antagonist
XCO:0000336
Any condition in which the main influencing factor is an agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists, substances that have an affinity for and stimulate physiologic activity at adrenergic receptors. Adrenergic receptors are a class of G protein-coupled receptors that are targets of catecholamines, especially norepinephrine and epinephrine.
CHEBI:37887
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Adrenergic_receptors
A condition in which an air jet, i.e. a rapid stream of air (the colorless, odorless, tasteless mixture of gases, mainly nitrogen, oxygen and lesser gases, plus water vapor and particulates, that surrounds the earth) forced under pressure through a small opening or nozzle, is directed toward the body or a part of the body of an organism.
jsmith
2013-08-22T17:01:21Z
experimental_condition_ontology
air-jet stress
forced air exposure
XCO:0000337
air-jet exposure
XCO:0000337
A condition in which an air jet, i.e. a rapid stream of air (the colorless, odorless, tasteless mixture of gases, mainly nitrogen, oxygen and lesser gases, plus water vapor and particulates, that surrounds the earth) forced under pressure through a small opening or nozzle, is directed toward the body or a part of the body of an organism.
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Any condition in which the main influencing factor is a particle, i.e. a body whose internal motion and structure, if any, are irrelevant in a specific problem, with a size between 1 and 100 nanometers composed of any substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules.
jsmith
2013-08-23T12:19:49Z
ultrafine chemical particle
experimental_condition_ontology
XCO:0000338
chemical nanoparticle
XCO:0000338
Any condition in which the main influencing factor is a particle, i.e. a body whose internal motion and structure, if any, are irrelevant in a specific problem, with a size between 1 and 100 nanometers composed of any substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Collins:Collins_Online_English_Dictionary
http://en.wikipedia.org/wiki/Nanoparticle
Any condition in which the main influencing factor is a particle, i.e. a body whose internal motion and structure, if any, are irrelevant in a specific problem, with a size between 1 and 100 nanometers composed of titanium dioxide. Titanium dioxide is a white insoluble powder that is the naturally occurring oxide of titanium, chemical formula TiO2, i.e. composed of one atom of titanium, the strong, low-density, highly corrosion-resistant metallic element with atomic number 22, and two atoms of oxygen, the highly reactive chemical element with atomic number 8 that is essential for plant and animal respiration and is required for nearly all combustion.
jsmith
2013-08-23T15:14:06Z
CHEBI:51050
titania nanoparticles
titanium(IV) oxide nanoparticles
experimental_condition_ontology
ultrafine TiO2 powder
ultrafine titanium dioxide powder
XCO:0000339
titanium dioxide nanoparticles
XCO:0000339
Any condition in which the main influencing factor is a particle, i.e. a body whose internal motion and structure, if any, are irrelevant in a specific problem, with a size between 1 and 100 nanometers composed of titanium dioxide. Titanium dioxide is a white insoluble powder that is the naturally occurring oxide of titanium, chemical formula TiO2, i.e. composed of one atom of titanium, the strong, low-density, highly corrosion-resistant metallic element with atomic number 22, and two atoms of oxygen, the highly reactive chemical element with atomic number 8 that is essential for plant and animal respiration and is required for nearly all combustion.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
http://en.wikipedia.org/wiki/Nanoparticle
http://en.wikipedia.org/wiki/Titanium_dioxide
Any condition in which the main influencing factor is a homogeneous mixture of molecules, atoms and/or ions dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
jsmith
2013-08-23T15:45:06Z
experimental_condition_ontology
XCO:0000340
solution
XCO:0000340
Any condition in which the main influencing factor is a homogeneous mixture of molecules, atoms and/or ions dispersed molecularly in a sufficient quantity of dissolving medium (solvent) such as water.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
This is any condition in which the main influencing factor is a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules and which has the capacity to perform a particular role or initiate or participate in a particular activity or process.
JSmith
2013-09-03T16:26:49Z
CHEBI:50906
chemical with specified role
experimental_condition_ontology
XCO:0000341
chemical with specified function
XCO:0000341
This is any condition in which the main influencing factor is a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules and which has the capacity to perform a particular role or initiate or participate in a particular activity or process.
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Collins:Collins_Online_English_Dictionary
Mosby:Mosbys_Dental_Dictionary--2nd_Ed
This is any condition in which the main influencing factor is a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules, where that molecular composition explicitly contains one or more particular parts or groups that are held or put together in a particular way.
JSmith
2013-09-03T16:30:12Z
CHEBI:24431
experimental_condition_ontology
Not4Curation
XCO:0000342
chemical with specified structure
XCO:0000342
This is any condition in which the main influencing factor is a substance having a specific molecular composition obtained by or used in a reaction involving changes to atoms or molecules, where that molecular composition explicitly contains one or more particular parts or groups that are held or put together in a particular way.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
American_Heritage:The_American_Heritage_Science_Dictionary_2005
Collins:Collins_Online_English_Dictionary
Any condition in which the main influencing factor is a chemical having a nitroso (R-N=O) and a urea moiety. A urea moiety consists of two -NH2 groups joined by a carbonyl (C=O) group.
JSmith
2013-09-04T13:12:02Z
experimental_condition_ontology
XCO:0000343
nitrosourea
XCO:0000343
Any condition in which the main influencing factor is a chemical having a nitroso (R-N=O) and a urea moiety. A urea moiety consists of two -NH2 groups joined by a carbonyl (C=O) group.
http://en.wikipedia.org/wiki/Nitrosourea
Any condition in which the main influencing factor is a chemical with three major moieties, a propyl group (a linear three-carbon alkyl substituent with chemical formula -C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
JSmith
2013-09-04T13:25:28Z
1-nitroso-1-propylurea
propylnitrosourea
experimental_condition_ontology
1-propyl-1-nitrosourea
PNU
XCO:0000344
N-propyl-N-nitrosourea
XCO:0000344
Any condition in which the main influencing factor is a chemical with three major moieties, a propyl group (a linear three-carbon alkyl substituent with chemical formula -C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
http://en.wikipedia.org/wiki/Nitrosourea
http://en.wikipedia.org/wiki/Propyl
pubchem.compound:13157
Any condition in which the main influencing factor is a chemical with three major moieties, an ethyl group (a two-carbon alkyl substituent with chemical formula -C2H5), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
JSmith
2013-09-04T13:34:43Z
CHEBI:23995
pubchem.compound:12967
N-ethyl-N-nitroso carbamide
ethylnitrosourea
experimental_condition_ontology
1-ethyl-1-nitrosourea
ENU
XCO:0000345
N-ethyl-N-nitrosourea
XCO:0000345
Any condition in which the main influencing factor is a chemical with three major moieties, an ethyl group (a two-carbon alkyl substituent with chemical formula -C2H5), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
http://en.wikipedia.org/wiki/Ethyl_group
http://en.wikipedia.org/wiki/Nitrosourea
Any condition in which the main influencing factor is a chemical with three major moieties, a methyl group (a one-carbon alkyl substituent with chemical formula -CH3), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
JSmith
2013-09-20T16:27:41Z
CHEBI:50102
pubchem.compound:12967
N-methyl-N-nitrosocarbamide
methylnitrosourea
experimental_condition_ontology
1-methyl-1-nitrosourea
MNU
XCO:0000346
N-methyl-N-nitrosourea
XCO:0000346
Any condition in which the main influencing factor is a chemical with three major moieties, a methyl group (a one-carbon alkyl substituent with chemical formula -CH3), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
http://en.wikipedia.org/wiki/Methyl_group
http://en.wikipedia.org/wiki/N-Methyl-N-nitrosourea
http://en.wikipedia.org/wiki/Nitrosourea
A surgical manipulation causing blockage of a blood vessel, any one of the network of muscular tubes that carry blood through the body.
JSmith
2013-11-11T10:32:17Z
experimental_condition_ontology
XCO:0000347
blood vessel occlusion
XCO:0000347
A surgical manipulation causing blockage of a blood vessel, any one of the network of muscular tubes that carry blood through the body.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A surgical manipulation causing blockage of the middle cerebral artery (MCA), one of the three major paired arteries that supply blood to the cerebrum. The MCA arises from the internal carotid and continues into the lateral sulcus where it branches and projects into the lateral cerebral cortex.
JSmith
2013-11-11T10:46:10Z
experimental_condition_ontology
MCA occlusion
XCO:0000348
middle cerebral artery occlusion
XCO:0000348
A surgical manipulation causing blockage of the middle cerebral artery (MCA), one of the three major paired arteries that supply blood to the cerebrum. The MCA arises from the internal carotid and continues into the lateral sulcus where it branches and projects into the lateral cerebral cortex.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Middle_Cerebral_Artery
Any phenomenon, chemical or biologic substance, or organism that, when administered, results in the inflammation of one or more joints, the sites of junction or union between bones, especially those that allow motion of the bones.
JSmith
2013-11-11T12:01:59Z
experimental_condition_ontology
XCO:0000349
arthritis-inducing agent
XCO:0000349
Any phenomenon, chemical or biologic substance, or organism that, when administered, results in the inflammation of one or more joints, the sites of junction or union between bones, especially those that allow motion of the bones.
Collins:Collins_Online_English_Dictionary
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A biologic agent consisting of a more or less purified preparation of cell walls from streptococcus bacteria. Streptococcus is a genus of spherical Gram-positive bacteria belonging to the phylum Firmicutes and the lactic acid bacteria group. The cell wall is the rigid structure that lies just outside of and is joined to the plasma membrane of plant cells and most prokaryotic cells, which protects the cell and maintains its shape.
JSmith
2013-11-11T12:03:50Z
experimental_condition_ontology
SCW
XCO:0000350
streptococcal cell wall
XCO:0000350
A biologic agent consisting of a more or less purified preparation of cell walls from streptococcus bacteria. Streptococcus is a genus of spherical Gram-positive bacteria belonging to the phylum Firmicutes and the lactic acid bacteria group. The cell wall is the rigid structure that lies just outside of and is joined to the plasma membrane of plant cells and most prokaryotic cells, which protects the cell and maintains its shape.
Collins:Collins_Online_English_Dictionary
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Streptococcus
A condition in which the major influencing factor is 4-nitroquinoline N-oxide, a tumorigenic derivative of quinoline N-oxide containing a nitro functional group (-NO2) at the 4 position of the quinoline bicyclic structure. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. 4-nitroquinoline 1-oxide and its metabolite 4-hydroxyaminoquinoline-1-oxide bind to nucleic acids and cause lesions usually corrected by nucleotide excision repair.
JSmith
2013-11-11T13:00:15Z
XCO:0000366
CHEBI:16907
MESH:D015112
4-Nitroquinoline 1-oxide
experimental_condition_ontology
4NQO
XCO:0000351
4-nitroquinoline N-oxide
XCO:0000351
A condition in which the major influencing factor is 4-nitroquinoline N-oxide, a tumorigenic derivative of quinoline N-oxide containing a nitro functional group (-NO2) at the 4 position of the quinoline bicyclic structure. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. 4-nitroquinoline 1-oxide and its metabolite 4-hydroxyaminoquinoline-1-oxide bind to nucleic acids and cause lesions usually corrected by nucleotide excision repair.
http://en.wikipedia.org/wiki/4-Nitroquinoline_1-oxide
http://en.wikipedia.org/wiki/Quinoline
A condition in which the major influencing factor is myelin, a lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the myelinated nerve fibers.
JSmith
2013-11-11T13:10:37Z
experimental_condition_ontology
XCO:0000352
myelin
XCO:0000352
A condition in which the major influencing factor is myelin, a lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the myelinated nerve fibers.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A condition in which the major influencing factor is the lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the myelinated nerve fibers of the central nervous system, i.e., the brain and spinal cord.
JSmith
2013-11-11T13:26:36Z
experimental_condition_ontology
CNS myelin
XCO:0000353
central nervous system myelin
XCO:0000353
A condition in which the major influencing factor is the lipoproteinaceous substance largely composed of phospholipids and proteins, which forms the sheaths surrounding the myelinated nerve fibers of the central nervous system, i.e., the brain and spinal cord.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A guanidine derivative with a nitro group (-NO2) on the nitrogen at position 3 and a methyl group (-CH3) and nitroso group (-NO) on the nitrogen at position 1. MNNG acts by adding alkyl groups to the O6 of guanine and O4 of thymine of DNA, giving it potent mutagenic and carcinogenic properties.
JSmith
2013-11-11T14:50:46Z
CHEBI:21759
pubchem.compound:9562060
1-methyl-3-nitro-1-nitrosoguanidine
methylnitronitrosoguanidine
experimental_condition_ontology
MNNG
XCO:0000354
N-methyl-N'-nitro-N-nitrosoguanidine
XCO:0000354
A guanidine derivative with a nitro group (-NO2) on the nitrogen at position 3 and a methyl group (-CH3) and nitroso group (-NO) on the nitrogen at position 1. MNNG acts by adding alkyl groups to the O6 of guanine and O4 of thymine of DNA, giving it potent mutagenic and carcinogenic properties.
MESH:D008769
http://en.wikipedia.org/wiki/Methylnitronitrosoguanidine
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). MNNG is a guanidine derivative with a nitro group (-NO2) on the nitrogen at position 3 and a methyl group (-CH3) and nitroso group (-NO) on the nitrogen at position 1. MNNG acts by adding alkyl groups to the O6 of guanine and O4 of thymine of DNA, giving it potent mutagenic and carcinogenic properties.
JSmith
2013-11-11T15:17:46Z
CHEBI:21759
controlled 1-methyl-3-nitro-1-nitrosoguanidine content drinking water
controlled methylnitronitrosoguanidine content drinking water
experimental_condition_ontology
controlled MNNG content drinking water
XCO:0000355
controlled N-methyl-N'-nitro-N-nitrosoguanidine content drinking water
XCO:0000355
A drink, that is, a liquid that is brought into the mouth and swallowed to quench thirst and/or for nourishment, made up of water and a specified amount of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and consumed by an organism as part of an experiment. Water is the clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O). MNNG is a guanidine derivative with a nitro group (-NO2) on the nitrogen at position 3 and a methyl group (-CH3) and nitroso group (-NO) on the nitrogen at position 1. MNNG acts by adding alkyl groups to the O6 of guanine and O4 of thymine of DNA, giving it potent mutagenic and carcinogenic properties.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
MESH:D008769
http://en.wikipedia.org/wiki/Methylnitronitrosoguanidine
http://www.yourdictionary.com/drink
A condition in which the major contributing factor is a preparation of spinal cord which has been rendered uniform in structure and/or composition throughout, for example by grinding the tissue until it has been reduced to particles which are evenly distributed thoughout a fluid. Spinal cord is the long, flexible, nearly cylindric structure of nerve tissue that extends from the medulla oblongata down through the vertebral canal and from which the spinal nerves branch off to various parts of the body.
JSmith
2013-11-11T15:35:41Z
experimental_condition_ontology
XCO:0000356
spinal cord homogenate
XCO:0000356
A condition in which the major contributing factor is a preparation of spinal cord which has been rendered uniform in structure and/or composition throughout, for example by grinding the tissue until it has been reduced to particles which are evenly distributed thoughout a fluid. Spinal cord is the long, flexible, nearly cylindric structure of nerve tissue that extends from the medulla oblongata down through the vertebral canal and from which the spinal nerves branch off to various parts of the body.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Mosby:Mosbys_Medical_Dictionary--8th_Ed
The action of ambulation on an exercise apparatus with an endless belt that allows the user to perform the action of running in place and that is maintained at an angle which deviates from the horozontal by a specified amount.
JSmith
2013-11-11T15:50:46Z
walking on sloped treadmill
experimental_condition_ontology
XCO:0000357
walking on inclined treadmill
XCO:0000357
The action of ambulation on an exercise apparatus with an endless belt that allows the user to perform the action of running in place and that is maintained at an angle which deviates from the horozontal by a specified amount.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
Encarta:Encarta_World_English_Dictionary
A substance administered specifically to aid diagnosis of a disease or condition.
JSmith
2013-11-11T16:04:05Z
experimental_condition_ontology
diagnostic aid
XCO:0000358
diagnostic agent
XCO:0000358
A substance administered specifically to aid diagnosis of a disease or condition.
CHEBI:33295
Webster:Random_House_Kernerman_Websters_College_Dictionary_2010
A condition in which the main influencing factor is an organic sodium salt that is the monosodium salt of p-aminohippuric acid, an amide derivative of the amino acid glycine and para-aminobenzoic acid. Sodium p-aminohippurate is used as a diagnostic agent in the measurement of renal plasma flow.
JSmith
2013-11-11T16:10:30Z
sodium para-aminohippurate
experimental_condition_ontology
PAH
XCO:0000359
sodium p-aminohippurate
XCO:0000359
A condition in which the main influencing factor is an organic sodium salt that is the monosodium salt of p-aminohippuric acid, an amide derivative of the amino acid glycine and para-aminobenzoic acid. Sodium p-aminohippurate is used as a diagnostic agent in the measurement of renal plasma flow.
CHEBI:104011
CHEBI:31204
http://en.wikipedia.org/wiki/Aminohippuric_acid
The insertion of a tubular, flexible surgical instrument into an artery to withdraw or introduce fluid. An artery is a vessel in which blood flows away from the heart.
JSmith
2013-12-20T12:41:32Z
experimental_condition_ontology
XCO:0000360
arterial catheter implantation
XCO:0000360
The insertion of a tubular, flexible surgical instrument into an artery to withdraw or introduce fluid. An artery is a vessel in which blood flows away from the heart.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
The forcible surgical separation from the spine of the motor root of a left side spinal nerve between the #3 and #5 lumbar vertebrae.
JSmith
2013-12-20T13:05:25Z
experimental_condition_ontology
XCO:0000361
left L3-L5 ventral root avulsion
XCO:0000361
The forcible surgical separation from the spine of the motor root of a left side spinal nerve between the #3 and #5 lumbar vertebrae.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Gale:Gale_Encyclopedia_of_Medicine_2008
The use of a pouch made from a very thin flexible plastic (any of various organic compounds produced by polymerization, capable of being molded, extruded, cast into various shapes and films) to limit some or all of an animal's normal movements.
JSmith
2013-12-20T13:13:08Z
experimental_condition_ontology
XCO:0000362
physical restraint in plastic bag
XCO:0000362
The use of a pouch made from a very thin flexible plastic (any of various organic compounds produced by polymerization, capable of being molded, extruded, cast into various shapes and films) to limit some or all of an animal's normal movements.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
Collins:Collins_Online_English_Dictionary
http://grants.nih.gov/grants/olaw/Guide-for-the-care-and-use-of-Laboratory-animals.pdf
A condition in which the main influencing factor is a single-celled or multicellular organism that has the capacity to cause disease, and the cell(s) of which individually have a true nucleus, that is, one that is bounded by a nuclear membrane, contains one or more chromosomes, and divides by mitosis.
JSmith
2013-12-20T13:28:29Z
experimental_condition_ontology
XCO:0000363
eukaryotic pathogen
XCO:0000363
A condition in which the main influencing factor is a single-celled or multicellular organism that has the capacity to cause disease, and the cell(s) of which individually have a true nucleus, that is, one that is bounded by a nuclear membrane, contains one or more chromosomes, and divides by mitosis.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
A condition in which the main influencing factor is a sporozoan species that is an intracellular parasite in a variety of vertebrates and is the causative agent of toxoplasmosis.
JSmith
2013-12-20T13:29:36Z
experimental_condition_ontology
XCO:0000364
Toxoplasma gondii
XCO:0000364
A condition in which the main influencing factor is a sporozoan species that is an intracellular parasite in a variety of vertebrates and is the causative agent of toxoplasmosis.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
A condition in which the main influencing factor is Toxoplasma gondii cysts. Toxoplasma gondii is a sporozoan species that is an intracellular parasite in a variety of vertebrates and is the causative agent of toxoplasmosis. Cyst refers to the larval stage in the life cycle during which individual organisms are enveloped in a protective wall.
JSmith
2013-12-20T13:30:01Z
experimental_condition_ontology
XCO:0000365
Toxoplasma gondii cysts
XCO:0000365
A condition in which the main influencing factor is Toxoplasma gondii cysts. Toxoplasma gondii is a sporozoan species that is an intracellular parasite in a variety of vertebrates and is the causative agent of toxoplasmosis. Cyst refers to the larval stage in the life cycle during which individual organisms are enveloped in a protective wall.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
true
XCO:0000366
A surgery in which a device is inserted which lacks the chemical or drug that in the experimental samples it would dispense.
JSmith
2013-12-20T14:06:20Z
experimental_condition_ontology
XCO:0000367
sham surgical device implantation
XCO:0000367
A surgery in which a device is inserted which lacks the chemical or drug that in the experimental samples it would dispense.
PMID:15687265
Any condition in which the main influencing factor is a chemical that causes an anti-self reaction by the immune system of the treated individual.
JSmith
2013-12-20T14:29:13Z
experimental_condition_ontology
XCO:0000368
autoimmune disease-inducing chemical
XCO:0000368
Any condition in which the main influencing factor is a chemical that causes an anti-self reaction by the immune system of the treated individual.
RGD:JRS
An antirheumatic of slow action that, in certain susceptible individuals, causes a gold-induced, Th2-dependent autoimmunity.
JSmith
2013-12-20T14:29:49Z
experimental_condition_ontology
Atps
allochrysine
aurotioprol
XCO:0000369
aurothiopropanol sulfonate
XCO:0000369
An antirheumatic of slow action that, in certain susceptible individuals, causes a gold-induced, Th2-dependent autoimmunity.
PMID:15128826
A condition in which the main influencing factor is any form of Trichinella spiralis, a nematode parasite that occurs in animals such as rodents, pigs, bears, and in humans. The organism, which matures in the intestines, producing larvae that travel through the blood and lymphatic systems to the muscles where they encyst, is responsible for the disease trichinosis.
JSmith
2014-01-09T13:19:52Z
experimental_condition_ontology
XCO:0000370
Trichinella spiralis
XCO:0000370
A condition in which the main influencing factor is any form of Trichinella spiralis, a nematode parasite that occurs in animals such as rodents, pigs, bears, and in humans. The organism, which matures in the intestines, producing larvae that travel through the blood and lymphatic systems to the muscles where they encyst, is responsible for the disease trichinosis.
http://en.wikipedia.org/wiki/Trichinella_spiralis
A condition in which the main influencing factor is the infective larvae of the nematode parasite Trichinella spiralis.
JSmith
2014-01-09T13:27:57Z
experimental_condition_ontology
XCO:0000371
Trichinella spiralis larvae
XCO:0000371
A condition in which the main influencing factor is the infective larvae of the nematode parasite Trichinella spiralis.
http://en.wikipedia.org/wiki/Trichinella_spiralis
A condition in which the main influencing factor is dexamethasone, a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities.
JSmith
2014-01-09T13:51:38Z
experimental_condition_ontology
XCO:0000372
dexamethasone
XCO:0000372
A condition in which the main influencing factor is dexamethasone, a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Dexamethasone
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682792.html
The resection or complete surgical removal of a nerve, any of the cordlike structures that convey impulses between the central nervous system and one or more parts of the body, and that each consist of an outer connective tissue sheath surrounding a bundle of conductive fibers.
JSmith
2014-01-09T14:52:48Z
MESH:D003714
experimental_condition_ontology
XCO:0000373
surgical denervation
XCO:0000373
The resection or complete surgical removal of a nerve, any of the cordlike structures that convey impulses between the central nervous system and one or more parts of the body, and that each consist of an outer connective tissue sheath surrounding a bundle of conductive fibers.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Dental_Dictionary--2nd_Ed
Surgical transection or severing of an axon, the process of a neuron capable of conducting action potentials or self-propagating nerve impulses away from the cell body.
JSmith
2014-01-09T14:56:20Z
MESH:D019771
experimental_condition_ontology
XCO:0000374
axotomy
XCO:0000374
Surgical transection or severing of an axon, the process of a neuron capable of conducting action potentials or self-propagating nerve impulses away from the cell body.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Surgical transection or severing of one or more axons of the sciatic nerve, the large sensory and motor nerve that in humans arises from the sacral plexus and passes through the greater sciatic foramen to midthigh where it divides into the common peroneal and tibial nerves.
JSmith
2014-01-09T14:57:23Z
MA:0001172
MESH:D019771
experimental_condition_ontology
XCO:0000375
sciatic nerve axotomy
XCO:0000375
Surgical transection or severing of one or more axons of the sciatic nerve, the large sensory and motor nerve that in humans arises from the sacral plexus and passes through the greater sciatic foramen to midthigh where it divides into the common peroneal and tibial nerves.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Surgical transection or severing of one or more axons of the saphenous nerve, a sensory nerve that is a terminal branch of the femoral nerve, in humans extending from the femoral triangle to the foot, becoming subcutaneous on the medial side of the knee.
JSmith
2014-01-09T14:57:26Z
MA:0002761
MESH:D019771
experimental_condition_ontology
XCO:0000376
saphenous nerve axotomy
XCO:0000376
Surgical transection or severing of one or more axons of the saphenous nerve, a sensory nerve that is a terminal branch of the femoral nerve, in humans extending from the femoral triangle to the foot, becoming subcutaneous on the medial side of the knee.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
Farlex:Farlex_Partner_Medical_Dictionary_2012
ISBN:978-1416049982
A condition in which the main influencing factor is any of a group of unrelated organic substances occurring in many foods in small amounts and necessary in trace amounts for the normal metabolic functioning of the body.
JSmith
2014-01-09T17:12:36Z
experimental_condition_ontology
XCO:0000377
vitamin
XCO:0000377
A condition in which the main influencing factor is any of a group of unrelated organic substances occurring in many foods in small amounts and necessary in trace amounts for the normal metabolic functioning of the body.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is any of a group of at least eight related fat-soluble compounds with similar biological antioxidant activity, particularly alpha-tocopherol but also including other isomers of tocopherol and the related compounds tocotrienol and tocomonoenol.
JSmith
2014-01-09T17:14:02Z
CHEBI:33234
experimental_condition_ontology
XCO:0000378
vitamin E
XCO:0000378
A condition in which the main influencing factor is any of a group of at least eight related fat-soluble compounds with similar biological antioxidant activity, particularly alpha-tocopherol but also including other isomers of tocopherol and the related compounds tocotrienol and tocomonoenol.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://www.cyberlipid.org/vite/vite0001.htm
A condition in which the main influencing factor is the most active form of vitamin E, a 6-hydroxychroman derivative (chromene) with methyl groups in position 2,5,7, and 8 and a phytyl side chain attached at carbon 2. May be described chemically as 2R-(4'R,8'R)-5,7,8-trimethyltocol, with the term tocol indicating the 2-ring structure (benzopyran-6-ol) basic to all vitamin E compounds.
JSmith
2014-01-09T17:15:15Z
CHEBI:22470
experimental_condition_ontology
a-tocopherol
XCO:0000379
alpha-tocopherol
XCO:0000379
A condition in which the main influencing factor is the most active form of vitamin E, a 6-hydroxychroman derivative (chromene) with methyl groups in position 2,5,7, and 8 and a phytyl side chain attached at carbon 2. May be described chemically as 2R-(4'R,8'R)-5,7,8-trimethyltocol, with the term tocol indicating the 2-ring structure (benzopyran-6-ol) basic to all vitamin E compounds.
http://www.cyberlipid.org/vite/vite0001.htm
A condition in which the main influencing factor is a hydrophobic 13 carbon saturated chain with methyl side groups at the 4', 8' and 12' positions. In its native form, the molecule is attached to the 2-carbon of the benzopyran-6-ol double ring structure of alpha-tocopherol.
JSmith
2014-01-09T17:16:43Z
experimental_condition_ontology
alpha-tocopherol phytyl side chain
XCO:0000380
phytyl side chain of alpha-tocopherol
XCO:0000380
A condition in which the main influencing factor is a hydrophobic 13 carbon saturated chain with methyl side groups at the 4', 8' and 12' positions. In its native form, the molecule is attached to the 2-carbon of the benzopyran-6-ol double ring structure of alpha-tocopherol.
http://www.cyberlipid.org/vite/vite0001.htm
Condition in which the main influencing factor is the steroid hormone progesterone, the principal pro-gestational hormone liberated by the corpus luteum, adrenal cortex, and placenta, whose function is to prepare the uterus for the reception and development of the fertilized oocyte by inducing transformation of the endometrium from the proliferative to the secretory stage.
JSmith
2014-01-09T17:37:07Z
experimental_condition_ontology
XCO:0000381
progesterone
XCO:0000381
Condition in which the main influencing factor is the steroid hormone progesterone, the principal pro-gestational hormone liberated by the corpus luteum, adrenal cortex, and placenta, whose function is to prepare the uterus for the reception and development of the fertilized oocyte by inducing transformation of the endometrium from the proliferative to the secretory stage.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A drink made up of water and a specified amount of captopril consumed by an organism as part of an experiment. Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure.
JSmith
2014-01-09T18:05:23Z
experimental_condition_ontology
XCO:0000382
controlled captopril content drinking water
XCO:0000382
A drink made up of water and a specified amount of captopril consumed by an organism as part of an experiment. Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Captopril
A drink made up of water and a specified amount of losartan consumed by an organism as part of an experiment. Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) receptor antagonist, reducing the end organ responses to angiotensin II.
JSmith
2014-01-09T18:07:00Z
experimental_condition_ontology
XCO:0000383
controlled losartan content drinking water
XCO:0000383
A drink made up of water and a specified amount of losartan consumed by an organism as part of an experiment. Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) receptor antagonist, reducing the end organ responses to angiotensin II.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Losartan
A drink made up of water and a specified amount of tempol consumed by an organism as part of an experiment. Tempol (4-Hydroxy-TEMPO) is a heterocyclic compound used as an agent for detoxifying reactive oxygen species. It catalyses the disproportionation of superoxide.
JSmith
2014-01-09T18:07:59Z
experimental_condition_ontology
XCO:0000384
controlled tempol content drinking water
XCO:0000384
A drink made up of water and a specified amount of tempol consumed by an organism as part of an experiment. Tempol (4-Hydroxy-TEMPO) is a heterocyclic compound used as an agent for detoxifying reactive oxygen species. It catalyses the disproportionation of superoxide.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/TEMPOL
Any substance, such as a chemical, a mix of chemicals or a pathogen, which has the capacity to cause the development of the symptoms of glomerulonephritis, kidney inflammation characterized by inflammation of the capillary loops in the renal glomeruli.
JSmith
2014-01-10T15:46:03Z
experimental_condition_ontology
XCO:0000385
glomerulonephritis-inducing agent
XCO:0000385
Any substance, such as a chemical, a mix of chemicals or a pathogen, which has the capacity to cause the development of the symptoms of glomerulonephritis, kidney inflammation characterized by inflammation of the capillary loops in the renal glomeruli.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
A condition in which the main influencing factor is a relatively undefined mix of macromolecules such as glycoproteins, proteoglycans, and fragmented collagens, derived from the basement membrane of renal glomeruli via treatment with collagenase, an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen, one of the major components of basement membranes. A basement membrane is an organised multi-molecular extracellular matrix which is characteristically found under epithelial and endothelial cells.
JSmith
2014-01-10T15:47:24Z
experimental_condition_ontology
collagenase-solubilized GBM
XCO:0000386
collagenase-solubilized glomerular basement membrane
XCO:0000386
A condition in which the main influencing factor is a relatively undefined mix of macromolecules such as glycoproteins, proteoglycans, and fragmented collagens, derived from the basement membrane of renal glomeruli via treatment with collagenase, an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen, one of the major components of basement membranes. A basement membrane is an organised multi-molecular extracellular matrix which is characteristically found under epithelial and endothelial cells.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Segen:Segens_Medical_Dictionary_2012
A condition in which the main influencing factor is a relatively undefined mix of macromolecules such as glycoproteins, proteoglycans, and fragmented collagens, derived from the basement membrane of renal glomeruli from rats (i.e., members of the species Rattus norvegicus) via treatment with collagenase, an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen, one of the major components of basement membranes. A basement membrane is an organised multi-molecular extracellular matrix which is characteristically found under epithelial and endothelial cells.
JSmith
2014-01-10T15:48:30Z
experimental_condition_ontology
collagenase-solubilized rat GBM
XCO:0000387
collagenase-solubilized rat glomerular basement membrane
XCO:0000387
A condition in which the main influencing factor is a relatively undefined mix of macromolecules such as glycoproteins, proteoglycans, and fragmented collagens, derived from the basement membrane of renal glomeruli from rats (i.e., members of the species Rattus norvegicus) via treatment with collagenase, an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen, one of the major components of basement membranes. A basement membrane is an organised multi-molecular extracellular matrix which is characteristically found under epithelial and endothelial cells.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Segen:Segens_Medical_Dictionary_2012
Condition in which the main influencing factor is acetaminophen, an analgesic and antipyretic with effects similar to aspirin but only weakly antiinflammatory.
JSmith
2014-01-21T16:34:04Z
CHEBI:46195
MESH:D000082
N-acetyl-p-aminophenol
para-acetylaminophenol
paracetamol
experimental_condition_ontology
APAP
XCO:0000388
acetaminophen
XCO:0000388
Condition in which the main influencing factor is acetaminophen, an analgesic and antipyretic with effects similar to aspirin but only weakly antiinflammatory.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the air surrounding an organism or breathed by the organism contains a controlled amount of cigarette smoke, the combined gases and particulates given off when tobacco in the form of a cigarette burns or smolders. A cigarette is a cylinder of cut blonde or black tobacco ensheathed in a tube of paper, with or without an incorporated filter to decrease inhaled tars.
JSmith
2014-01-21T16:58:06Z
experimental_condition_ontology
exposure to atmospheric cigarette smoke
XCO:0000389
controlled cigarette smoke content
XCO:0000389
A condition in which the air surrounding an organism or breathed by the organism contains a controlled amount of cigarette smoke, the combined gases and particulates given off when tobacco in the form of a cigarette burns or smolders. A cigarette is a cylinder of cut blonde or black tobacco ensheathed in a tube of paper, with or without an incorporated filter to decrease inhaled tars.
McGraw-Hill:McGraw-Hill_Concise_Dictionary_of_Modern_Medicine
A condition in which the main influencing factor is a substance which competes with or replaces a metabolite (a chemical that is part of the normal metabolism of a cell or body), and so prevents or reduces its normal utilization or activity. Antimetabolites are often structurally similar to the metabolite for which they substitute.
JSmith
2014-02-07T15:47:34Z
CHEBI:35221
MESH:D000963
experimental_condition_ontology
XCO:0000390
antimetabolite
XCO:0000390
A condition in which the main influencing factor is a substance which competes with or replaces a metabolite (a chemical that is part of the normal metabolism of a cell or body), and so prevents or reduces its normal utilization or activity. Antimetabolites are often structurally similar to the metabolite for which they substitute.
http://en.wikipedia.org/wiki/Antimetabolite
A condition in which the main influencing factor is 5-bromo-2'-deoxyuridine (BrdU), a synthetic nucleoside analog and antimetabolite of thymidine. Because BrdU substitutes for thymidine in DNA during replication its incorporation can be used as a marker of cell division.
JSmith
2014-02-07T15:58:44Z
CHEBI:472552
MESH:D001973
experimental_condition_ontology
BrdU
bromodeoxyuridine
XCO:0000391
5-bromo-2'-deoxyuridine
XCO:0000391
A condition in which the main influencing factor is 5-bromo-2'-deoxyuridine (BrdU), a synthetic nucleoside analog and antimetabolite of thymidine. Because BrdU substitutes for thymidine in DNA during replication its incorporation can be used as a marker of cell division.
http://en.wikipedia.org/wiki/Bromodeoxyuridine
A condition in which the main influencing factor is any of various compounds consisting of a purine or pyrimidine base and a sugar, usually ribose or deoxyribose, with (nucleotide) or without (nucleoside) one or more phosphate groups.
JSmith
2014-02-07T16:00:28Z
experimental_condition_ontology
XCO:0000392
nucleoside/nucleotide
XCO:0000392
A condition in which the main influencing factor is any of various compounds consisting of a purine or pyrimidine base and a sugar, usually ribose or deoxyribose, with (nucleotide) or without (nucleoside) one or more phosphate groups.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
http://en.wikipedia.org/wiki/Nucleotide
A condition in which the main influencing factor is 1,2-dimethylhydrazine, DNA alkylating agent that is a potent carcinogen; used to induce colon tumours in experimental animals.
JSmith
2014-02-07T16:46:23Z
CHEBI:73755
MESH:D019813
N,N'-dimethylhydrazine
experimental_condition_ontology
Hydrazomethane
SDMH
symmetrical dimethylhydrazine
XCO:0000393
1,2-dimethylhydrazine
XCO:0000393
A condition in which the main influencing factor is 1,2-dimethylhydrazine, DNA alkylating agent that is a potent carcinogen; used to induce colon tumours in experimental animals.
Mondofacto:Mondofacto_Online_Medical_Dictionary
http://en.wikipedia.org/wiki/1,2-dimethylhydrazine
A regimen of solid food to which a specified amount of bile acid has been added. Bile acids are steroid acids derived from cholesterol in the liver (primary) or produced from primary bile acids by intestinal bacteria (secondary).
JSmith
2014-02-07T16:57:51Z
experimental_condition_ontology
XCO:0000394
controlled bile acid content diet
XCO:0000394
A regimen of solid food to which a specified amount of bile acid has been added. Bile acids are steroid acids derived from cholesterol in the liver (primary) or produced from primary bile acids by intestinal bacteria (secondary).
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A drink made up of water and a specified amount of 4-nitroquinoline N-oxide, a tumorigenic derivative of quinoline N-oxide containing a nitro functional group (-NO2) at the 4 position of the quinoline bicyclic structure. 4-nitroquinoline 1-oxide and its metabolite 4-hydroxyaminoquinoline-1-oxide bind to nucleic acids and cause lesions usually corrected by nucleotide excision repair.
JSmith
2014-02-07T17:03:31Z
CHEBI:16907
MESH:D015112
controlled 4-Nitroquinoline 1-oxide drinking water
experimental_condition_ontology
controlled 4NQO drinking water
XCO:0000395
controlled 4-nitroquinoline N-oxide content drinking water
XCO:0000395
A drink made up of water and a specified amount of 4-nitroquinoline N-oxide, a tumorigenic derivative of quinoline N-oxide containing a nitro functional group (-NO2) at the 4 position of the quinoline bicyclic structure. 4-nitroquinoline 1-oxide and its metabolite 4-hydroxyaminoquinoline-1-oxide bind to nucleic acids and cause lesions usually corrected by nucleotide excision repair.
http://en.wikipedia.org/wiki/4-Nitroquinoline_1-oxide
Any organic aromatic compound consisting of at least one phenolic group, that is, a group having one or more hydroxy groups attached to a benzene or other arene ring.
JSmith
2014-02-27T13:23:28Z
CHEBI:33853
experimental_condition_ontology
XCO:0000396
phenolic/phenol derivative
XCO:0000396
A synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor.
JSmith
2014-02-27T13:28:43Z
CHEBI:33216
experimental_condition_ontology
BPA
XCO:0000397
bisphenol A
XCO:0000397
A synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor.
http://en.wikipedia.org/wiki/Bisphenol_A
A condition in which the main influencing factor is cisplatin, a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion. Cisplatin is mutagenic and serves as an anti-cancer drug through its ability to bind to and crosslink DNA, interfering with cell division, triggering DNA repair mechanisms and, in turn, activating apoptosis.
JSmith
2014-02-27T15:53:25Z
CHEBI:27899
experimental_condition_ontology
XCO:0000398
cisplatin
XCO:0000398
A condition in which the main influencing factor is cisplatin, a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion. Cisplatin is mutagenic and serves as an anti-cancer drug through its ability to bind to and crosslink DNA, interfering with cell division, triggering DNA repair mechanisms and, in turn, activating apoptosis.
CHEBI:27899
http://en.wikipedia.org/wiki/Cisplatin
A metal ion surrounded by, and forming coordinate covalent bonds with, a set of ligands comprised of any combination of other molecules or ions able to donate an electron pair.
JSmith
2014-02-27T15:55:56Z
experimental_condition_ontology
XCO:0000399
complex ion
XCO:0000399
A metal ion surrounded by, and forming coordinate covalent bonds with, a set of ligands comprised of any combination of other molecules or ions able to donate an electron pair.
http://chemwiki.ucdavis.edu/Inorganic_Chemistry/Coordination_Chemistry/Complex_Ion_Equilibria/Complex-Ion_Equilibria
http://www.chemguide.co.uk/inorganic/complexions/whatis.html#top
A surgical manipulation in which one tissue, organ or body part is forcibly torn away from the whole, or in which an attached or anchored tissue is torn away from another tissue or body part.
JSmith
2014-02-27T17:28:06Z
experimental_condition_ontology
XCO:0000400
surgical avulsion
XCO:0000400
A surgical manipulation in which one tissue, organ or body part is forcibly torn away from the whole, or in which an attached or anchored tissue is torn away from another tissue or body part.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Segen:Segens_Medical_Dictionary_2012
The surgical tearing apart of the nerve root, the part of a nerve adjacent to the center to which it is connected, from that center, for example, surgical separation of one or both of two bundles of nerve fibers (the posterior and anterior roots) from the spinal cord by tearing rather than cutting.
JSmith
2014-02-27T17:29:08Z
experimental_condition_ontology
XCO:0000401
nerve root avulsion
XCO:0000401
The surgical tearing apart of the nerve root, the part of a nerve adjacent to the center to which it is connected, from that center, for example, surgical separation of one or both of two bundles of nerve fibers (the posterior and anterior roots) from the spinal cord by tearing rather than cutting.
Farlex:Farlex_Partner_Medical_Dictionary_2012
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A condition in which an experimental subject is exposed to an experimental apparatus in order to habituate the individual to the apparatus. Habituation is the gradual decrease in behavioral responses to a particular stimulus or environment after repeated exposures have proven to be of no consequence.
JSmith
2014-02-28T11:38:55Z
experimental_condition_ontology
XCO:0000402
habituation to experimental apparatus
XCO:0000402
A condition in which an experimental subject is exposed to an experimental apparatus in order to habituate the individual to the apparatus. Habituation is the gradual decrease in behavioral responses to a particular stimulus or environment after repeated exposures have proven to be of no consequence.
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
http://en.wikipedia.org/wiki/Habituation
A solid diet in which the amount of cisplatin, a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion, is maintained at a specified level.
JSmith
2014-02-28T12:22:58Z
CHEBI:27899
experimental_condition_ontology
XCO:0000403
controlled cisplatin content diet
XCO:0000403
A solid diet in which the amount of cisplatin, a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion, is maintained at a specified level.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A solid diet in which the amount of bisphenol A is maintained at a specified level. Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor.
JSmith
2014-02-28T12:23:03Z
CHEBI:33216
experimental_condition_ontology
controlled BPA content diet
XCO:0000404
controlled bisphenol A content diet
XCO:0000404
A solid diet in which the amount of bisphenol A is maintained at a specified level. Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Bisphenol_A
A drink made up of water and a specified amount of cisplatin consumed by an organism as part of an experiment. Cisplatin is a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion.
JSmith
2014-02-28T12:48:11Z
CHEBI:27899
experimental_condition_ontology
XCO:0000405
controlled cisplatin content drinking water
XCO:0000405
A drink made up of water and a specified amount of cisplatin consumed by an organism as part of an experiment. Cisplatin is a chemotherapy drug in which two ammine ligands and two chloro ligands are oriented in a cis planar configuration around a central platinum ion.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Cisplatin
A drink made up of water and a specified amount of bisphenol A consumed by an organism as part of an experiment. Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor.
JSmith
2014-02-28T12:48:15Z
CHEBI:33216
experimental_condition_ontology
controlled BPA content drinking water
XCO:0000406
controlled bisphenol A content drinking water
XCO:0000406
A drink made up of water and a specified amount of bisphenol A consumed by an organism as part of an experiment. Bisphenol A is a synthetic phenolic compound with the chemical formula (CH3)2C(C6H4OH)2, i.e. one in which a central carbon links to two methyl groups and two hydroxyphenyl groups. BPA is similar in structure to estradiol and can bind to and activate the estrogen receptor.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Bisphenol_A
This is any condition in which the main influencing factor is a substance which has the ability to lower the level of glucose, particularly blood glucose, in an organism.
JSmith
2014-02-28T17:14:36Z
CHEBI:35526
antihyperglycemic agent
experimental_condition_ontology
antidiabetic drug
antidiabetic agent
XCO:0000407
hypoglycemic agent
XCO:0000407
A condition in which the main influencing factor is metformin, an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis).
JSmith
2014-02-28T17:17:09Z
CHEBI:6801
Glucophage
experimental_condition_ontology
XCO:0000408
metformin
XCO:0000408
A condition in which the main influencing factor is metformin, an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis).
http://en.wikipedia.org/wiki/Metformin
A drink made up of water and a specified amount of metformin consumed by an organism as part of an experiment. Metformin is an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis).
JSmith
2014-02-28T17:27:21Z
CHEBI:6801
experimental_condition_ontology
XCO:0000409
controlled metformin content drinking water
XCO:0000409
A drink made up of water and a specified amount of metformin consumed by an organism as part of an experiment. Metformin is an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis).
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Metformin
A solid diet in which the amount of metformin, an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis), is maintained at a specified level.
JSmith
2014-02-28T17:29:02Z
CHEBI:6801
experimental_condition_ontology
XCO:0000410
controlled metformin content diet
XCO:0000410
A solid diet in which the amount of metformin, an oral antidiabetic drug in the biguanide class which functions to supress the production of glucose by the liver (hepatic gluconeogenesis), is maintained at a specified level.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Metformin
Any experimental condition that is specifically related to the reproduction of the organism, that is, to the cellular, genetic, behavioral and temporal processes by which an organism produces offspring similar to itself so that the species is perpetuated.
JSmith
2014-03-04T12:21:41Z
experimental_condition_ontology
XCO:0000411
reproduction condition
XCO:0000411
Any experimental condition that is specifically related to the reproduction of the organism, that is, to the cellular, genetic, behavioral and temporal processes by which an organism produces offspring similar to itself so that the species is perpetuated.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
The state of a female and/or her offspring, and the processes which occur, during the period from conception to birth or termination of the pregnancy.
JSmith
2014-03-04T12:29:54Z
experimental_condition_ontology
pregnancy
XCO:0000412
gestation
XCO:0000412
The state of a female and/or her offspring, and the processes which occur, during the period from conception to birth or termination of the pregnancy.
Farlex:Farlex_Partner_Medical_Dictionary_2012
The emergence and separation of offspring from the body of the mother.
JSmith
2014-03-04T12:36:04Z
experimental_condition_ontology
parturition
XCO:0000413
birth
XCO:0000413
The emergence and separation of offspring from the body of the mother.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
The process of synthesis and secretion of milk from the mammary glands in the nourishment of offspring.
JSmith
2014-03-04T12:38:40Z
experimental_condition_ontology
breast feeding
milk production
XCO:0000414
lactation
XCO:0000414
The process of synthesis and secretion of milk from the mammary glands in the nourishment of offspring.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
The nutrient fluid produced by the mammary gland of a female mammal for the nourishment of her young and consumed by her offspring or a fosterling of the same species.
JSmith
2014-03-04T12:44:39Z
experimental_condition_ontology
breast milk
mother's milk
XCO:0000415
maternal milk
XCO:0000415
The nutrient fluid produced by the mammary gland of a female mammal for the nourishment of her young and consumed by her offspring or a fosterling of the same species.
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
A nutrient fluid containing proteins, fats, lactose, and various vitamins and minerals produced by the mammary gland of a female mammal.
JSmith
2014-03-04T12:54:50Z
experimental_condition_ontology
XCO:0000416
milk
XCO:0000416
A nutrient fluid containing proteins, fats, lactose, and various vitamins and minerals produced by the mammary gland of a female mammal.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
A solid diet in which the amount of one or more phytoestrogens, any of a group of weakly estrogenic, nonsteroidal compounds widely occurring in plants, is maintained at a specified level.
JSmith
2014-03-04T13:32:02Z
CHEBI:76989
experimental_condition_ontology
XCO:0000417
controlled phytoestrogen content diet
XCO:0000417
A solid diet in which the amount of one or more phytoestrogens, any of a group of weakly estrogenic, nonsteroidal compounds widely occurring in plants, is maintained at a specified level.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A solid diet which specifically contains no phytoestrogens, any of a group of weakly estrogenic, nonsteroidal compounds widely occurring in plants.
JSmith
2014-03-04T13:35:13Z
CHEBI:76989
experimental_condition_ontology
XCO:0000418
phytoestrogen-free diet
XCO:0000418
A solid diet which specifically contains no phytoestrogens, any of a group of weakly estrogenic, nonsteroidal compounds widely occurring in plants.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A solid diet specifically containing no soy, that is, no derivative of soybeans, the bean of the leguminous plant, Glycine max, which contains little starch but is rich in protein and phytoestrogens.
JSmith
2014-03-04T13:38:15Z
experimental_condition_ontology
XCO:0000419
soy-free diet
XCO:0000419
A solid diet specifically containing no soy, that is, no derivative of soybeans, the bean of the leguminous plant, Glycine max, which contains little starch but is rich in protein and phytoestrogens.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A condition in which the environment of the offspring within the uterus is controlled during any or all of the period between fertilization and parturition.
JSmith
2014-03-04T13:53:44Z
experimental_condition_ontology
controlled gestational environment
XCO:0000420
controlled in utero environment
XCO:0000420
A condition in which the environment of the offspring within the uterus is controlled during any or all of the period between fertilization and parturition.
Farlex:Farlex_Partner_Medical_Dictionary_2012
Any condition which occurs while an organism is still within the uterus of its mother during the gestation period.
JSmith
2014-03-04T15:25:32Z
experimental_condition_ontology
XCO:0000421
in utero condition
XCO:0000421
Any condition which occurs while an organism is still within the uterus of its mother during the gestation period.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Any condition in which the main influencing factor is a quinone, a member of a class of compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds.
JSmith
2014-03-04T17:35:52Z
CHEBI:36141
experimental_condition_ontology
XCO:0000422
quinone
XCO:0000422
A condition in which the main influencing factor is thymoquinone, an antioxidant phytochemical compound found in the plant Nigella sativa. Thymoquinone has the chemical formula C10H12O2 and is a 1,4-benzoquinone substituted at the 2 and 5 position with a methyl and an isopropyl group (2-Isopropyl-5-methyl- or 5-Isopropyl-2-methyl-).
JSmith
2014-03-04T17:36:38Z
CHEBI:113532
MESH:C003466
pubchem.compound:10281
2-isopropyl-5-methylbenzoquinone
2-methyl-5-isopropyl-p-benzoquinone
2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione
dihydrothymoquinone
experimental_condition_ontology
XCO:0000423
thymoquinone
XCO:0000423
A condition in which the main influencing factor is thymoquinone, an antioxidant phytochemical compound found in the plant Nigella sativa. Thymoquinone has the chemical formula C10H12O2 and is a 1,4-benzoquinone substituted at the 2 and 5 position with a methyl and an isopropyl group (2-Isopropyl-5-methyl- or 5-Isopropyl-2-methyl-).
http://en.wikipedia.org/wiki/Thymoquinone
A condition in which the main influencing factor is benfotiamine, a synthetic thioester S-acyl derivative and analogue of thiamine (vitamin B1); used as an antioxidant dietary supplement.
JSmith
2014-03-04T17:48:57Z
CHEBI:41039
S-benzoylthiamine O-monophosphate
experimental_condition_ontology
XCO:0000424
benfotiamine
XCO:0000424
A condition in which the main influencing factor is benfotiamine, a synthetic thioester S-acyl derivative and analogue of thiamine (vitamin B1); used as an antioxidant dietary supplement.
http://en.wikipedia.org/wiki/Benfotiamine
A condition in which the main influencing factor is lactotransferrin, a multifunctional protein of the transferrin family which is a major iron-binding protein in milk and body secretions, and has antimicrobial activity.
JSmith
2014-03-05T09:50:27Z
lactoferrin
experimental_condition_ontology
LTF
XCO:0000425
lactotransferrin
XCO:0000425
A condition in which the main influencing factor is lactotransferrin, a multifunctional protein of the transferrin family which is a major iron-binding protein in milk and body secretions, and has antimicrobial activity.
RGD:1313477
http://en.wikipedia.org/wiki/Lactoferrin
This is any condition in which the main influencing factor is 1H-pyrazole, a heterocyclic organic compound with the formula C3H3N2H which is a 5-membered ring of three carbon atoms and two adjacent nitrogen centers, i.e., with nitrogens at positions 1 and 2 of the ring. 1H-pyrazole is a tautomer of 3H-pyrazole and 4H-pyrazole. Pyrazole is a core motif in many antioxidant molecules.
JSmith
2014-03-05T09:52:40Z
CHEBI:17241
PMID:34355092
1,2-Diazacyclopenta-2,4-diene
pyrazole
experimental_condition_ontology
1,2-diazole
XCO:0000426
1H-pyrazole
XCO:0000426
This is any condition in which the main influencing factor is 1H-pyrazole, a heterocyclic organic compound with the formula C3H3N2H which is a 5-membered ring of three carbon atoms and two adjacent nitrogen centers, i.e., with nitrogens at positions 1 and 2 of the ring. 1H-pyrazole is a tautomer of 3H-pyrazole and 4H-pyrazole. Pyrazole is a core motif in many antioxidant molecules.
http://en.wikipedia.org/wiki/Pyrazole
A condition in which the main influencing factor is lycopene, a bright red polyunsaturated carotenoid hydrocarbon (i.e. a carotene) with the formula C40H56. Lycopene is a tetraterpene assembled from eight isoprene units and has antioxidant activity.
JSmith
2014-03-05T09:54:44Z
CHEBI:15948
experimental_condition_ontology
XCO:0000427
lycopene
XCO:0000427
A condition in which the main influencing factor is lycopene, a bright red polyunsaturated carotenoid hydrocarbon (i.e. a carotene) with the formula C40H56. Lycopene is a tetraterpene assembled from eight isoprene units and has antioxidant activity.
http://en.wikipedia.org/wiki/Lycopene
This is any condition in which the main influencing factor is fructose, a monosaccharide isomer of glucose which, although it is a 6-carbon sugar (hexose), generally exists as a 5-member hemiketal ring. Fructose is one of three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion.
JSmith
2014-03-05T10:26:45Z
CHEBI:15824
CHEBI:28757
experimental_condition_ontology
XCO:0000428
fructose
XCO:0000428
This is any condition in which the main influencing factor is fructose, a monosaccharide isomer of glucose which, although it is a 6-carbon sugar (hexose), generally exists as a 5-member hemiketal ring. Fructose is one of three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion.
http://en.wikipedia.org/wiki/Fructose
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of fructose consumed by a subject. Fructose is one of three dietary monosaccharides that are absorbed directly into the bloodstream during digestion.
JSmith
2014-03-05T10:27:59Z
PMID:33790226
experimental_condition_ontology
XCO:0000429
controlled fructose content drinking water
XCO:0000429
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of fructose consumed by a subject. Fructose is one of three dietary monosaccharides that are absorbed directly into the bloodstream during digestion.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Fructose
A condition in which the main influencing factor is silymarin, a strongly antioxidant mixture of flavonolignans extracted from the milk thistle plant (Silybum marianum). The components or silymarin are capable of scavenging both free radicals and reactive oxygen species (ROS).
JSmith
2014-03-05T10:39:11Z
experimental_condition_ontology
XCO:0000430
silymarin
XCO:0000430
A condition in which the main influencing factor is silymarin, a strongly antioxidant mixture of flavonolignans extracted from the milk thistle plant (Silybum marianum). The components or silymarin are capable of scavenging both free radicals and reactive oxygen species (ROS).
PMID:24145092
Any condition in which the main influencing factor is a disaccharide, a member of the class of sugars that yield two monosaccharide molecules upon hydrolysis.
JSmith
2014-03-07T10:28:37Z
experimental_condition_ontology
XCO:0000431
disaccharide
XCO:0000431
Any condition in which the main influencing factor is a disaccharide, a member of the class of sugars that yield two monosaccharide molecules upon hydrolysis.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Any condition in which the main influencing factor is sucrose, a nonreducing disaccharide of glucose and fructose used as a food, a sweetener, a preservative and a pharmaceutical aid.
JSmith
2014-03-07T10:31:32Z
CHEBI:17992
experimental_condition_ontology
XCO:0000432
sucrose
XCO:0000432
Any condition in which the main influencing factor is sucrose, a nonreducing disaccharide of glucose and fructose used as a food, a sweetener, a preservative and a pharmaceutical aid.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A drink made up of water and a specified amount of sucrose consumed by an organism as part of an experiment. Sucrose is a nonreducing disaccharide of glucose and fructose used as a food, a sweetener, a preservative and a pharmaceutical aid.
JSmith
2014-03-07T10:33:57Z
CHEBI:17992
experimental_condition_ontology
XCO:0000433
controlled sucrose content drinking water
XCO:0000433
A drink made up of water and a specified amount of sucrose consumed by an organism as part of an experiment. Sucrose is a nonreducing disaccharide of glucose and fructose used as a food, a sweetener, a preservative and a pharmaceutical aid.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Condition in which the main influencing factor is octylphenol, a phenolic ring with an 8-carbon side chain.
JSmith
2014-03-07T13:09:25Z
CHEBI:34432
experimental_condition_ontology
XCO:0000434
octylphenol
XCO:0000434
This is any condition in which the main influencing factor is any chemical that inhibits or prevents the proliferation of neoplasms.
JSmith
2014-03-12T13:30:22Z
CHEBI:35610
experimental_condition_ontology
anticancer agent
cancer chemotherapy agent
XCO:0000435
antineoplastic agent
XCO:0000435
A solid diet in which the amount of N-propyl-N-nitrosourea (PNU) is maintained at a specified level. PNU is a mutation-inducing chemical with three major moieties, a propyl group (-C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
JSMITH
2014-04-17T12:42:14Z
controlled 1-nitroso-1-propylurea content diet
controlled propylnitrosourea content diet
experimental_condition_ontology
controlled 1-propyl-1-nitrosourea content diet
controlled PNU content diet
XCO:0000436
controlled N-propyl-N-nitrosourea content diet
XCO:0000436
A solid diet in which the amount of N-propyl-N-nitrosourea (PNU) is maintained at a specified level. PNU is a mutation-inducing chemical with three major moieties, a propyl group (-C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Nitrosourea
pubchem.compound:13157
A drink made up of water and a specified amount of N-propyl-N-nitrosourea (PNU) consumed by an organism as part of an experiment. PNU is a mutation-inducing chemical with three major moieties, a propyl group (-C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
JSMITH
2014-04-17T12:42:20Z
controlled 1-nitroso-1-propylurea content drinking water
controlled propylnitrosourea content drinking water
experimental_condition_ontology
controlled 1-propyl-1-nitrosourea content drinking water
controlled PNU content drinking water
XCO:0000437
controlled N-propyl-N-nitrosourea content drinking water
XCO:0000437
A drink made up of water and a specified amount of N-propyl-N-nitrosourea (PNU) consumed by an organism as part of an experiment. PNU is a mutation-inducing chemical with three major moieties, a propyl group (-C3H7), a nitroso group (R-N=O) and a urea group (two -NH2 groups joined by a carbonyl (C=O) functional group).
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Nitrosourea
pubchem.compound:13157
A condition in which the main influencing factor is candesartan, the angiotensin II receptor 1 (AT1) antagonist which exhibits antihypertensive effects in animal models.
JSMITH
2014-04-17T13:11:54Z
CHEBI:3348
MESH:C081643
2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
TCV-116
experimental_condition_ontology
XCO:0000438
candesartan
XCO:0000438
A condition in which the main influencing factor is candesartan, the angiotensin II receptor 1 (AT1) antagonist which exhibits antihypertensive effects in animal models.
http://en.wikipedia.org/wiki/Candesartan
A drink made up of water and a specified amount of 3-methyl-4'-dimethylaminoazobenzene (MDAB), a substituted azobenzene compound that acts as a potent liver carcinogen, consumed by an organism as part of an experiment.
JSMITH
2014-04-17T15:49:17Z
CHEBI:76329
controlled 4-Dimethylamino-3'-methylazobenzene content drinking water
controlled methyldimethylaminoazobenzene content drinking water
experimental_condition_ontology
controlled 3'-Me-DAB content drinking water
controlled 3'-methyl-4-(dimethylamino)azobenzene content drinking water
controlled MDAB content drinking water
XCO:0000439
controlled 3-methyl-4'-dimethylaminoazobenzene content drinking water
XCO:0000439
A drink made up of water and a specified amount of 3-methyl-4'-dimethylaminoazobenzene (MDAB), a substituted azobenzene compound that acts as a potent liver carcinogen, consumed by an organism as part of an experiment.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://potency.berkeley.edu/chempages/3%27-METHYL-4-DIMETHYLAMINOAZOBENZENE.html
A solid diet in which the amount of 3'-methyl-4-dimethylaminoazobenzene (MDAB), a substituted azobenzene compound that acts as a potent liver carcinogen, is maintained at a specified level.
JSMITH
2014-04-17T15:49:21Z
CHEBI:76329
controlled 3'-methyl-4-(dimethylamino)azobenzene content diet
controlled 4-Dimethylamino-3'-methylazobenzene content diet
controlled methyldimethylaminoazobenzene content diet
experimental_condition_ontology
controlled 3'-Me-DAB content diet
controlled MDAB content diet
XCO:0000440
controlled 3-methyl-4'-dimethylaminoazobenzene content diet
XCO:0000440
A solid diet in which the amount of 3'-methyl-4-dimethylaminoazobenzene (MDAB), a substituted azobenzene compound that acts as a potent liver carcinogen, is maintained at a specified level.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://potency.berkeley.edu/chempages/3%27-METHYL-4-DIMETHYLAMINOAZOBENZENE.html
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of 2-acetamidofluorene, a substituted ortho-fused polycyclic arene that is a carcinogenic and mutagenic derivative of fluorene, consumed by a subject.
JSMITH
2014-04-17T16:31:36Z
CHEBI:17356
experimental_condition_ontology
controlled 2-AAF content drinking water
controlled 2-acetylaminofluorene content drinking water
XCO:0000441
controlled 2-acetamidofluorene content drinking water
XCO:0000441
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of 2-acetamidofluorene, a substituted ortho-fused polycyclic arene that is a carcinogenic and mutagenic derivative of fluorene, consumed by a subject.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://en.wikipedia.org/wiki/Acetylaminofluorene
A solid diet in which the amount of 2-acetamidofluorene, a substituted ortho-fused polycyclic arene that is a carcinogenic and mutagenic derivative of fluorene, is maintained at a specified level.
JSMITH
2014-04-17T16:31:40Z
CHEBI:17356
experimental_condition_ontology
controlled 2-AAF content diet
controlled 2-acetylaminofluorene content diet
XCO:0000442
controlled 2-acetamidofluorene content diet
XCO:0000442
A solid diet in which the amount of 2-acetamidofluorene, a substituted ortho-fused polycyclic arene that is a carcinogenic and mutagenic derivative of fluorene, is maintained at a specified level.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Acetylaminofluorene
A solid diet in which the amount of dexamethasone (DEX) is maintained at a specified level. DEX is a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities.
JSmith
2014-04-24T13:35:39Z
experimental_condition_ontology
controlled DEX content diet
XCO:0000443
controlled dexamethasone content diet
XCO:0000443
A solid diet in which the amount of dexamethasone (DEX) is maintained at a specified level. DEX is a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Dexamethasone
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682792.html
A drink made up of water and a specified amount of dexamethasone (DEX) consumed by an organism as part of an experiment. DEX is a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities.
JSmith
2014-04-24T13:35:46Z
experimental_condition_ontology
controlled DEX content drinking water
XCO:0000444
controlled dexamethasone content drinking water
XCO:0000444
A drink made up of water and a specified amount of dexamethasone (DEX) consumed by an organism as part of an experiment. DEX is a long-acting synthetic adrenocorticoid, analogous to but more potent than cortisol (a natural hormone produced by the adrenal glands), with anti-inflammatory and immunosuppressant activities.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Dexamethasone
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682792.html
A relatively standardized solution of sodium chloride to which one or more phosphate salts have been added to maintain a neutral pH. PBS is isotonic, that is, the ionic strength of PBS is close to that inside living cells.
JSmith
2014-04-24T14:08:08Z
CHEBI:26020
CHEBI:26710
CHEBI:35225
experimental_condition_ontology
PBS
phosphate-buffer sodium chloride solution
XCO:0000445
phosphate buffered saline
XCO:0000445
A relatively standardized solution of sodium chloride to which one or more phosphate salts have been added to maintain a neutral pH. PBS is isotonic, that is, the ionic strength of PBS is close to that inside living cells.
http://en.wikipedia.org/wiki/Phosphate_buffered_saline
One of the two types of reproductive cycles. Specifically, the correlated phenomena of the endocrine and reproductive systems of a female (especially, non-primate) mammal resulting in regularly occurring periods during which the female is sexually active and receptive, estrus, separated by periods in which there is no sexual receptivity.
JSmith
2014-05-15T18:09:42Z
estrous cycle
experimental_condition_ontology
estral cycle
XCO:0000446
estrus cycle
XCO:0000446
One of the two types of reproductive cycles. Specifically, the correlated phenomena of the endocrine and reproductive systems of a female (especially, non-primate) mammal resulting in regularly occurring periods during which the female is sexually active and receptive, estrus, separated by periods in which there is no sexual receptivity.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
A regularly recurrent state of sexual excitability during which the female of non-primate mammalian species will accept the male and is capable of conceiving.
JSmith
2014-05-15T18:16:20Z
oestrus
experimental_condition_ontology
estrous
heat
XCO:0000447
estrus
XCO:0000447
A regularly recurrent state of sexual excitability during which the female of non-primate mammalian species will accept the male and is capable of conceiving.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
Mosby:Mosbys_Medical_Dictionary--8th_Ed
The period of regression and sexual inactivity in females of non-primate mammalian species between estrus and diestrus.
JSmith
2014-05-15T18:25:00Z
experimental_condition_ontology
metestrous
XCO:0000448
metestrus
XCO:0000448
The period of regression and sexual inactivity in females of non-primate mammalian species between estrus and diestrus.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
A period of sexual quiescence that intervenes between two periods of estrus in females of non-primate mammalian species between. In general during diestrus blood levels of estrogens are minimal, progesterone levels are high and the physiological state in the uterus is most conducive for implantation and growth of the developing fetus.
JSmith
2014-05-15T18:29:26Z
experimental_condition_ontology
diestrous
XCO:0000449
diestrus
XCO:0000449
A period of sexual quiescence that intervenes between two periods of estrus in females of non-primate mammalian species between. In general during diestrus blood levels of estrogens are minimal, progesterone levels are high and the physiological state in the uterus is most conducive for implantation and growth of the developing fetus.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
A preparatory period immediately preceding estrus and characterized by growth of graafian follicles, increased estrogenic activity, and alteration of uterine and vaginal mucosa.
JSmith
2014-05-15T18:33:04Z
experimental_condition_ontology
proestrous
XCO:0000450
proestrus
XCO:0000450
A preparatory period immediately preceding estrus and characterized by growth of graafian follicles, increased estrogenic activity, and alteration of uterine and vaginal mucosa.
Merriam-Webster:Merriam-Websters_Online_Dictionary--11th_Ed
A condition in which the main influencing factor is a neurotropic virus that is a member of the Herpesviridae family and that, once the infection becomes chronic, has the ability to cycle through recurring outbreak periods followed by periods of latency or dormancy in which the virus is inactive but still present in infected nerve cells. HSV1 causes primarily mouth, throat, face, eye, and central nervous system infections.
JSmith
2014-05-15T19:05:50Z
experimental_condition_ontology
HSV-1
Herpes simplex virus 1
XCO:0000451
Herpes simplex virus type 1
XCO:0000451
A condition in which the main influencing factor is a neurotropic virus that is a member of the Herpesviridae family and that, once the infection becomes chronic, has the ability to cycle through recurring outbreak periods followed by periods of latency or dormancy in which the virus is inactive but still present in infected nerve cells. HSV1 causes primarily mouth, throat, face, eye, and central nervous system infections.
http://en.wikipedia.org/wiki/Herpes_simplex_virus
A solid diet in which the amount of casein is maintained at a specified level. Casein, a phosphoprotein, is the principle protein component of milk.
JSmith
2014-06-12T17:25:24Z
experimental_condition_ontology
controlled caseinogen content diet
XCO:0000452
controlled casein content diet
XCO:0000452
A solid diet in which the amount of casein is maintained at a specified level. Casein, a phosphoprotein, is the principle protein component of milk.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
This is a solid diet in which the amount of butter is maintained at a specified level. Butter is a soft yellowish or whitish emulsion of milk fat, water and air, churned from milk or cream and processed for use in cooking and as a food.
JSmith
2014-06-12T17:27:00Z
experimental_condition_ontology
XCO:0000453
controlled butter content diet
XCO:0000453
This is a solid diet in which the amount of butter is maintained at a specified level. Butter is a soft yellowish or whitish emulsion of milk fat, water and air, churned from milk or cream and processed for use in cooking and as a food.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A solid diet in which the amount of a specified oil is maintained at a specified level. An oil is any unctuous, combustible substance that is liquid, or easily liquefiable, on warming, and is soluble in ether but not in water. Oils may be animal, vegetable, or mineral in origin.
JSmith
2014-06-12T17:27:48Z
experimental_condition_ontology
XCO:0000454
controlled oil content diet
XCO:0000454
A solid diet in which the amount of a specified oil is maintained at a specified level. An oil is any unctuous, combustible substance that is liquid, or easily liquefiable, on warming, and is soluble in ether but not in water. Oils may be animal, vegetable, or mineral in origin.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A solid diet in which the amount of corn oil is maintained at a specified level. Corn oil is a refined fixed, that is, nonvolatile, oil obtained from corn, the embryo of Zea mays plant. It is sometimes promoted as a good source of polyunsaturated fatty acids.
JSmith
2014-06-12T17:28:44Z
experimental_condition_ontology
XCO:0000455
controlled corn oil content diet
XCO:0000455
A solid diet in which the amount of corn oil is maintained at a specified level. Corn oil is a refined fixed, that is, nonvolatile, oil obtained from corn, the embryo of Zea mays plant. It is sometimes promoted as a good source of polyunsaturated fatty acids.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any condition in which the primary influencing agent is retinyl palmitate, the synthetic ester of retinol (vitamin A) and palmitic acid, with formula C36H60O2.
JSmith
2014-06-12T17:56:00Z
experimental_condition_ontology
retinol palmitate
XCO:0000456
retinyl palmitate
XCO:0000456
Any condition in which the primary influencing agent is retinyl palmitate, the synthetic ester of retinol (vitamin A) and palmitic acid, with formula C36H60O2.
http://en.wikipedia.org/wiki/Retinyl_palmitate
A solid diet in which the amount of any retinoid is maintained at a specified level. Retinoids comprise retinal, retinol and any structurally similar natural derivative or synthetic compound, with or without vitamin A activity.
JSmith
2014-06-12T17:57:57Z
controlled vitamin A content diet
experimental_condition_ontology
XCO:0000457
controlled retinoid content diet
XCO:0000457
A solid diet in which the amount of any retinoid is maintained at a specified level. Retinoids comprise retinal, retinol and any structurally similar natural derivative or synthetic compound, with or without vitamin A activity.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A solid diet in which the amount of retinyl palmitate is maintained at a specified level. Retinyl palmitate is the synthetic ester of retinol (vitamin A) and palmitic acid, with formula C36H60O2.
JSmith
2014-06-12T17:59:02Z
experimental_condition_ontology
controlled retinol palmitate content diet
XCO:0000458
controlled retinyl palmitate content diet
XCO:0000458
A solid diet in which the amount of retinyl palmitate is maintained at a specified level. Retinyl palmitate is the synthetic ester of retinol (vitamin A) and palmitic acid, with formula C36H60O2.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
http://en.wikipedia.org/wiki/Retinyl_palmitate
A recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth.
JSmith
2014-06-17T16:30:05Z
experimental_condition_ontology
XCO:0000459
controlled light/dark cycle
XCO:0000459
A recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Induction and/or maintenance of a hollow cavity beneath the skin between the scapulae (the flat triangular bones at the top or back of the shoulder), by injection or other introduction of a specified volume of air. Experimental air pouches are often used to encapsulate foreign cells or other substances.
JSmith
2014-06-17T17:19:15Z
experimental_condition_ontology
XCO:0000460
subcutaneous interscapular air pouch
XCO:0000460
Induction and/or maintenance of a hollow cavity beneath the skin between the scapulae (the flat triangular bones at the top or back of the shoulder), by injection or other introduction of a specified volume of air. Experimental air pouches are often used to encapsulate foreign cells or other substances.
PMID:17277140
PMID:7019400
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
A dietary regimen in which access to food is limited, e.g. to a specified number of hours per day or to a specified part of the light-dark cycle, with or without restrictions in the amount or type of food available when feeding is allowed.
JSmith
2014-06-23T16:24:46Z
experimental_condition_ontology
TRF
time-restricted feeding
XCO:0000461
restricted feeding
XCO:0000461
A dietary regimen in which access to food is limited, e.g. to a specified number of hours per day or to a specified part of the light-dark cycle, with or without restrictions in the amount or type of food available when feeding is allowed.
PMID:24739093
The portion of a controlled light/dark cycle in which the subject is exposed to ambient light (that is, during which the room is lit). A controlled light/dark cycle is a recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth.
JSmith
2014-08-26T13:10:29Z
experimental_condition_ontology
XCO:0000462
light phase of controlled light/dark cycle
XCO:0000462
The portion of a controlled light/dark cycle in which the subject is exposed to ambient light (that is, during which the room is lit). A controlled light/dark cycle is a recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
The portion of a controlled light/dark cycle in which the subject is not being exposed to ambient light (that is, during which the room is darkened). A controlled light/dark cycle is a recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth.
JSmith
2014-08-26T13:12:48Z
experimental_condition_ontology
XCO:0000463
dark phase of controlled light/dark cycle
XCO:0000463
The portion of a controlled light/dark cycle in which the subject is not being exposed to ambient light (that is, during which the room is darkened). A controlled light/dark cycle is a recurring series of conditions in which an organism experiences successive periods of exposure to controlled ambient light followed by exposure to darkness, the lack of such light, which is in turn followed by exposure to controlled ambient light and so forth.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Any experimental condition in which the internal or external environment of an organ, that is, a differentiated, structural part of a system of the body that performs a specific function, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body.
JSmith
2015-01-13T12:48:26Z
experimental_condition_ontology
XCO:0000464
controlled ex vivo organ condition
XCO:0000464
Any experimental condition in which the internal or external environment of an organ, that is, a differentiated, structural part of a system of the body that performs a specific function, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body.
Farlex:Farlex_Partner_Medical_Dictionary_2012
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Any experimental condition in which the internal or external environment of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body.
JSmith
2015-01-13T12:59:22Z
experimental_condition_ontology
XCO:0000465
controlled ex vivo artery condition
XCO:0000465
Any experimental condition in which the internal or external environment of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body.
Farlex:Farlex_Partner_Medical_Dictionary_2012
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A condition in which the pressure, or force per area, exerted by a perfusate against the walls of an artery after removal from the body but while the tissue is still viable, is regulated or maintained at a specified level.
JSmith
2015-01-13T13:16:48Z
controlled ex vivo artery intraluminal pressure
experimental_condition_ontology
XCO:0000466
controlled ex vivo artery perfusion pressure
XCO:0000466
A condition in which the pressure, or force per area, exerted by a perfusate against the walls of an artery after removal from the body but while the tissue is still viable, is regulated or maintained at a specified level.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
Farlex:Farlex_Partner_Medical_Dictionary_2012
ISBN:978-1416049982
Condition in which the main influencing factor is a retinoid, any of a group of compounds containing 20 carbon atoms and structurally related to retinal, retinol, and other substances, some of which exhibit vitamin A activity.
JSmith
2015-03-06T18:09:40Z
CHEBI:26537
experimental_condition_ontology
XCO:0000467
retinoid
XCO:0000467
Condition in which the main influencing factor is a retinoid, any of a group of compounds containing 20 carbon atoms and structurally related to retinal, retinol, and other substances, some of which exhibit vitamin A activity.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Condition in which the main influencing factor is vitamin A, a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.
JSmith
2015-03-06T18:11:00Z
CHEBI:12777
experimental_condition_ontology
XCO:0000468
vitamin A
XCO:0000468
Condition in which the main influencing factor is vitamin A, a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.
http://en.wikipedia.org/wiki/Vitamin_A
https://ods.od.nih.gov/factsheets/VitaminA-Consumer/
Condition in which the main influencing factor is isotretinoin, a synthetic first generation retinoid compound used for the treatment of severe cases of acne and other skin diseases.
JSmith
2015-03-06T18:13:57Z
CHEBI:6067
13-cis-retinoic acid
13cRA
Accutane
experimental_condition_ontology
Roaccutane
XCO:0000469
isotretinoin
XCO:0000469
Condition in which the main influencing factor is isotretinoin, a synthetic first generation retinoid compound used for the treatment of severe cases of acne and other skin diseases.
http://en.wikipedia.org/wiki/Retinoid
Condition in which the main influencing factor is a flavonoid, any of a class of plant secondary metabolites that have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and a heterocyclic ring (C).
JSmith
2015-03-06T18:16:29Z
experimental_condition_ontology
bioflavonoid
XCO:0000470
flavonoid
XCO:0000470
Condition in which the main influencing factor is a flavonoid, any of a class of plant secondary metabolites that have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and a heterocyclic ring (C).
http://en.wikipedia.org/wiki/Flavonoid
Condition in which the main influencing factor is quercetin, a pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is a yellow flavonoid pigment found in oak bark, the juice of lemons, asparagus, and other fruits and vegetables and is used to reduce abnormal capillary fragility.
JSmith
2015-03-06T18:17:55Z
CHEBI:16243
experimental_condition_ontology
meletin
XCO:0000471
quercetin
XCO:0000471
Condition in which the main influencing factor is quercetin, a pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is a yellow flavonoid pigment found in oak bark, the juice of lemons, asparagus, and other fruits and vegetables and is used to reduce abnormal capillary fragility.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Condition in which the main influencing factor is chrysin, a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.
JSmith
2015-03-06T18:19:02Z
CHEBI:75095
experimental_condition_ontology
5,7-dihydroxyflavone
XCO:0000472
chrysin
XCO:0000472
Condition in which the main influencing factor is naringenin, a trihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 6 and 4'. Naringenin is the predominant flavanone in grapefruit and has demonstrated inhibitory activity against the CYP1A2 cytochrome P450 isoform.
JSmith
2015-03-06T18:20:06Z
CHEBI:50202
experimental_condition_ontology
XCO:0000473
naringenin
XCO:0000473
Condition in which the main influencing factor is naringenin, a trihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 6 and 4'. Naringenin is the predominant flavanone in grapefruit and has demonstrated inhibitory activity against the CYP1A2 cytochrome P450 isoform.
http://en.wikipedia.org/wiki/Naringenin
Condition in which the main influencing factor is alendronate (the anionic form of alendronic acid), a bisphosphonate drug used for osteoporosis and several other bone diseases, because it inhibits osteoclast-mediated bone-resorption.
JSmith
2015-03-06T18:29:05Z
CHEBI:2567
CHEBI:50647
Binosto
Fosamax
sodium alendronate
experimental_condition_ontology
alendronic acid
XCO:0000474
alendronate
XCO:0000474
Condition in which the main influencing factor is alendronate (the anionic form of alendronic acid), a bisphosphonate drug used for osteoporosis and several other bone diseases, because it inhibits osteoclast-mediated bone-resorption.
http://en.wikipedia.org/wiki/Alendronic_acid
Any condition in which the primary influencing agent is a bacterial pathogen, a disease-causing unicellular prokaryotic microorganism that commonly multiplies by cell division, lacks a nucleus or membrane-bound organelles, and generally has a cell wall.
JSmith
2015-04-29T14:14:39Z
experimental_condition_ontology
pathogenic bacteria
XCO:0000475
bacterial pathogen
XCO:0000475
Any condition in which the primary influencing agent is a bacterial pathogen, a disease-causing unicellular prokaryotic microorganism that commonly multiplies by cell division, lacks a nucleus or membrane-bound organelles, and generally has a cell wall.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the primary influencing factor is Streptococcus pneumoniae, a species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers.
JSmith
2015-04-30T13:35:44Z
NCBITaxon:1313
experimental_condition_ontology
XCO:0000476
Streptococcus pneumoniae
XCO:0000476
A condition in which the primary influencing factor is Streptococcus pneumoniae, a species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers.
http://en.wikipedia.org/wiki/Streptococcus_pneumoniae
A condition in which the primary influencing factor is Streptococcus pneumoniae D39, a potentially virulent strain of the S. pneumoniae species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers.
JSmith
2015-04-30T13:36:39Z
NCBITaxon:373153
Streptococcus pneumoniae strain D39
experimental_condition_ontology
XCO:0000477
Streptococcus pneumoniae D39
XCO:0000477
A condition in which the primary influencing factor is Streptococcus pneumoniae D39, a potentially virulent strain of the S. pneumoniae species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers.
http://en.wikipedia.org/wiki/Streptococcus_pneumoniae
A condition in which the primary influencing factor is Streptococcus pneumoniae TIGR4, a potentially virulent strain of the S. pneumoniae species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers.
JSmith
2015-04-30T13:38:57Z
NCBITaxon:170187
Streptococcus pneumoniae strain TIGR4
experimental_condition_ontology
XCO:0000478
Streptococcus pneumoniae TIGR4
XCO:0000478
A condition in which the primary influencing factor is Streptococcus pneumoniae TIGR4, a potentially virulent strain of the S. pneumoniae species of Gram-positive, alpha-hemolytic, facultative anaerobic bacteria commonly found in the nasopharynx of healthy human carriers.
http://en.wikipedia.org/wiki/Streptococcus_pneumoniae
A condition in which the primary influencing factor is Haemophilus influenzae, a Gram-negative, coccobacillary, facultatively anaerobic bacterium which is considered an opportunistic pathogen, i.e. one that can colonize a host without causing disease unless there are extenuating circumstances which result in susceptibility on the part of the host.
JSmith
2015-04-30T13:41:32Z
NCBITaxon:727
experimental_condition_ontology
XCO:0000479
Haemophilus influenzae
XCO:0000479
A condition in which the primary influencing factor is Haemophilus influenzae, a Gram-negative, coccobacillary, facultatively anaerobic bacterium which is considered an opportunistic pathogen, i.e. one that can colonize a host without causing disease unless there are extenuating circumstances which result in susceptibility on the part of the host.
http://en.wikipedia.org/wiki/Haemophilus_influenzae
A condition in which the primary influencing factor is one or more nontypeable strain(s) of Haemophilus influenzae (NTHi). NTHi refers to any unencapsulated strain of the Gram-negative, coccobacillary, facultatively anaerobic bacterium species Haemophilus influenza. Such bacteria lack the capsular antigens used to serotype strains and therefore cannot be classified by serology. NTHi strains are the important pathogens in chronic and recurrent otitis media in children.
JSmith
2015-04-30T13:42:32Z
experimental_condition_ontology
NTHi
XCO:0000480
nontypeable Haemophilus influenzae
XCO:0000480
A condition in which the primary influencing factor is one or more nontypeable strain(s) of Haemophilus influenzae (NTHi). NTHi refers to any unencapsulated strain of the Gram-negative, coccobacillary, facultatively anaerobic bacterium species Haemophilus influenza. Such bacteria lack the capsular antigens used to serotype strains and therefore cannot be classified by serology. NTHi strains are the important pathogens in chronic and recurrent otitis media in children.
PMID:15968074
http://en.wikipedia.org/wiki/Haemophilus_influenzae
A condition in which the primary influencing factor is the 86-028NP strain of Haemophilus influenzae. 86-028NP is a pathogenic, nontypeable H. influenzae strain isolated from the nasopharynx of a child with chronic otitis media.
JSmith
2015-04-30T13:48:27Z
NCBITaxon:281310
Haemophilus influenzae strain 86-028NP
experimental_condition_ontology
86028NP
NTHi 86-028NP
XCO:0000481
Haemophilus influenzae 86-028NP
XCO:0000481
A condition in which the primary influencing factor is the 86-028NP strain of Haemophilus influenzae. 86-028NP is a pathogenic, nontypeable H. influenzae strain isolated from the nasopharynx of a child with chronic otitis media.
PMID:15968074
http://en.wikipedia.org/wiki/Haemophilus_influenzae
A substance that kills or slows the growth of one or more microorganisms, including bacteria, viruses, fungi and protozoans.
JSmith
2015-04-30T14:25:42Z
CHEBI:33281
experimental_condition_ontology
antibiotic
XCO:0000482
antimicrobial agent
XCO:0000482
This is any condition in which the main influencing factor is an antibacterial agent, a substance that kills or slows the growth of bacteria, unicellular prokaryotic microorganisms that commonly multiply by cell division, lack a nucleus or membrane-bound organelles, and generally have a cell wall.
JSmith
2015-04-30T14:31:11Z
CHEBI:33282
experimental_condition_ontology
XCO:0000483
antibacterial agent
XCO:0000483
This is any condition in which the main influencing factor is an antibacterial agent, a substance that kills or slows the growth of bacteria, unicellular prokaryotic microorganisms that commonly multiply by cell division, lack a nucleus or membrane-bound organelles, and generally have a cell wall.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
This is any condition in which the main influencing factor is ceftriaxone, a third-generation cephalosporin antibacterial agent with broad-spectrum activity against both Gram-positive and Gram-negative bacteria.
JSmith
2015-04-30T14:44:33Z
CHEBI:29007
experimental_condition_ontology
XCO:0000484
ceftriaxone
XCO:0000484
This is any condition in which the main influencing factor is ceftriaxone, a third-generation cephalosporin antibacterial agent with broad-spectrum activity against both Gram-positive and Gram-negative bacteria.
http://en.wikipedia.org/wiki/Ceftriaxone
A condition in which the primary influencing factor is the H2 mutant of the 86-028NP strain of Haemophilus influenzae.
JSmith
2015-05-14T17:54:23Z
NCBITaxon:281310
Haemophilus influenzae mutant strain 86-028NP-H2
experimental_condition_ontology
86H2
NTHi 86-028NP H2 mutant
XCO:0000485
Haemophilus influenzae 86-028NP H2 mutant
XCO:0000485
A condition in which the primary influencing factor is the H2 mutant of the 86-028NP strain of Haemophilus influenzae.
RGD:JRS
A condition in which the primary influencing factor is the C5 mutant of the 86-028NP strain of Haemophilus influenzae.
JSmith
2015-05-14T17:58:28Z
NCBITaxon:281310
Haemophilus influenzae mutant strain 86-028NP-C5
experimental_condition_ontology
86C5
NTHi 86-028NP C5 mutant
XCO:0000486
Haemophilus influenzae 86-028NP C5 mutant
XCO:0000486
A condition in which the primary influencing factor is the C5 mutant of the 86-028NP strain of Haemophilus influenzae.
RGD:JRS
A condition in which the primary influencing factor is the LuxS mutant of Streptococcus pneumoniae TIGR4.
JSmith
2015-05-14T17:59:26Z
NCBITaxon:170187
Streptococcus pneumoniae mutant strain TIGR4luxS
experimental_condition_ontology
TIGR4luxS
XCO:0000487
Streptococcus pneumoniae TIGR4 LuxS mutant
XCO:0000487
A condition in which the primary influencing factor is the LuxS mutant of Streptococcus pneumoniae TIGR4.
RGD:JRS
Any condition related to or affecting the external interactions and relationships of a single organism, between single organisms, or within or between groups of organisms.
jesmith
2015-12-07T15:12:14Z
experimental_condition_ontology
social context condition
XCO:0000488
social environment condition
XCO:0000488
Any condition related to or affecting the external interactions and relationships of a single organism, between single organisms, or within or between groups of organisms.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
Any condition in which the social environment of an organism is set or changed for a specified and/or limited period of time.
jesmith
2015-12-07T15:40:22Z
experimental_condition_ontology
XCO:0000489
temporary social environment condition
XCO:0000489
Any condition in which the social environment of an organism is set or changed for a specified and/or limited period of time.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
Any condition in which the social environment of an organism is set or changed for an extended period of time or on a continual basis.
jesmith
2015-12-07T15:56:22Z
experimental_condition_ontology
XCO:0000490
ongoing social environment condition
XCO:0000490
Any condition in which the social environment of an organism is set or changed for an extended period of time or on a continual basis.
Collins:Collins_Online_English_Dictionary
An experimental condition in which a test subject is placed in social contact with an organism from the same species. A species is a fundamental category of taxonomic classification, ranking below a genus and consisting of related organisms capable of interbreeding.
jesmith
2015-12-07T15:59:02Z
experimental_condition_ontology
XCO:0000491
controlled exposure to an organism of the same species
XCO:0000491
An experimental condition in which a test subject is placed in social contact with an organism from the same species. A species is a fundamental category of taxonomic classification, ranking below a genus and consisting of related organisms capable of interbreeding.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
This is an experimental condition in which a test subject is placed in social contact with a juvenile (young, not yet mature, not fully grown and/or not fully developed) organism from the same species.
jesmith
2015-12-07T16:11:18Z
controlled exposure to an adolescent of the same species
experimental_condition_ontology
XCO:0000492
controlled exposure to a juvenile of the same species
XCO:0000492
This is an experimental condition in which a test subject is placed in social contact with a juvenile (young, not yet mature, not fully grown and/or not fully developed) organism from the same species.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
https://www.merriam-webster.com
An experimental condition in which a test subject is placed in social contact with an adult (an organism that is fully developed and has reached physical and/or sexual maturity) from the same species.
jesmith
2015-12-07T16:18:25Z
experimental_condition_ontology
XCO:0000493
controlled exposure to an adult of the same species
XCO:0000493
An experimental condition in which a test subject is placed in social contact with an adult (an organism that is fully developed and has reached physical and/or sexual maturity) from the same species.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
The physiological period after the natural cessation of estrus or menstruation cycles in an aging female mammal.
jesmith
2016-02-01T11:00:34Z
experimental_condition_ontology
post-productive period
postmenopausal
XCO:0000494
postmenopause
XCO:0000494
The physiological period after the natural cessation of estrus or menstruation cycles in an aging female mammal.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
http://www.medicaldictionaryweb.com/Postmenopause-definition/
A condition in which the main influencing factor is any substance that is poisonous or destructive to nerve cells or tissue, or that can be metabolized into a substance that is destructive to nerve cells or tissue.
jesmith
2016-04-25T13:04:37Z
neurotoxin
experimental_condition_ontology
XCO:0000495
Note that, although commonly used to refer to any neurotoxic substance, the term "neurotoxin" is technically restricted to naturally occurring proteins or peptides which are neurotoxic.
neurotoxic substance
XCO:0000495
A condition in which the main influencing factor is any substance that is poisonous or destructive to nerve cells or tissue, or that can be metabolized into a substance that is destructive to nerve cells or tissue.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is a peptide, a protein or a conjugated protein produced by some higher plants, animals, and pathogenic bacteria, that is poisonous or destructive to nerve cells or tissue.
jesmith
2016-04-25T13:25:58Z
experimental_condition_ontology
XCO:0000496
neurotoxin
XCO:0000496
A condition in which the main influencing factor is a peptide, a protein or a conjugated protein produced by some higher plants, animals, and pathogenic bacteria, that is poisonous or destructive to nerve cells or tissue.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
A condition in which the main influencing factor is a synthetic or naturally derived compound that causes loss of dopaminergic neurons and induces Parkinson-like symptoms (parkinsonism) in animal models and/or Parkinson disease in humans.
jesmith
2016-04-25T13:44:48Z
MESH:D010300
Parkinson's disease inducing chemical
experimental_condition_ontology
parkinsonism-inducing chemical
XCO:0000497
Parkinson disease inducing chemical
XCO:0000497
A condition in which the main influencing factor is a synthetic or naturally derived compound that causes loss of dopaminergic neurons and induces Parkinson-like symptoms (parkinsonism) in animal models and/or Parkinson disease in humans.
PMID:22108613
A condition in which the main influencing factor is oxidopamine, a neurotoxic organic compound used to induce degeneration of dopaminergic neurons in animal models.
jesmith
2016-04-25T15:27:15Z
CHEBI:78741
experimental_condition_ontology
6-OHDA
6-hydoxydopamine
XCO:0000498
oxidopamine
XCO:0000498
A condition in which the main influencing factor is oxidopamine, a neurotoxic organic compound used to induce degeneration of dopaminergic neurons in animal models.
PMID:22108613
A condition in which the main influencing factor is1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the precursor to the toxic metabolite MPP+ (1-methyl-4-phenylpyridinium cation) which promotes degeneration of dopaminergic neurons.
jesmith
2016-04-25T15:31:31Z
CHEBI:17963
experimental_condition_ontology
MPTP
XCO:0000499
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
XCO:0000499
A condition in which the main influencing factor is1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the precursor to the toxic metabolite MPP+ (1-methyl-4-phenylpyridinium cation) which promotes degeneration of dopaminergic neurons.
PMID:22108613
A condition in which the main influencing factor is paraquat, a herbicidal organic cation used to model Parkinson's disease in mice.
jesmith
2016-04-25T15:35:55Z
CHEBI:34905
experimental_condition_ontology
XCO:0000500
paraquat
XCO:0000500
A condition in which the main influencing factor is paraquat, a herbicidal organic cation used to model Parkinson's disease in mice.
PMID:22108613
A condition in which the main influencing factor is rotenone, an insecticide and piscicide extracted from Leguminosa plants. Rotenone can be used to induce degeneration of dopaminergic neurons in animal models.
jesmith
2016-04-25T15:41:51Z
CHEBI:28201
experimental_condition_ontology
XCO:0000501
rotenone
XCO:0000501
A condition in which the main influencing factor is rotenone, an insecticide and piscicide extracted from Leguminosa plants. Rotenone can be used to induce degeneration of dopaminergic neurons in animal models.
PMID:22108613
A condition characterized by an alteration in the placement, arrangement or orientation of any part of the body of an organism such as an organ or extremity.
jesmith
2017-02-22T18:31:25Z
experimental_condition_ontology
XCO:0000502
body part position change
XCO:0000502
A condition characterized by an alteration in the placement, arrangement or orientation of any part of the body of an organism such as an organ or extremity.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--5th_Ed
https://en.wiktionary.org/wiki/body_part
A condition characterized by an alteration in the placement, arrangement or orientation of the head of an organism.
jesmith
2017-02-22T18:33:23Z
change in position of the head
experimental_condition_ontology
XCO:0000503
head position change
XCO:0000503
A condition characterized by an alteration in the placement, arrangement or orientation of the head of an organism.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--5th_Ed
https://en.wiktionary.org/wiki/body_part
A condition characterized by rotation or twisting of the head parallel to the coronal plane of the body (that is, the plane which separates the belly from the back of the organism) at an increasing velocity.
jesmith
2017-02-22T18:34:51Z
experimental_condition_ontology
coronal plane angular acceleration of the head
XCO:0000504
coronal plane rotational acceleration of the head
XCO:0000504
A condition characterized by rotation or twisting of the head parallel to the coronal plane of the body (that is, the plane which separates the belly from the back of the organism) at an increasing velocity.
PMID:27188340
A condition in which the main influencing factor is a chemical which counteracts or suppresses inflammation.
jesmith
2017-02-22T18:36:33Z
CHEBI:67079
antiinflammatory agent
experimental_condition_ontology
XCO:0000505
anti-inflammatory agent
XCO:0000505
A condition in which the main influencing factor is a chemical which counteracts or suppresses inflammation.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
A condition in which the main influencing factor is a chemical which counteracts or suppresses inflammation but which is not a steroid.
jesmith
2017-02-22T18:40:46Z
CHEBI:35475
experimental_condition_ontology
NSAID
XCO:0000506
non-steroidal anti-inflammatory drug
XCO:0000506
A condition in which the main influencing factor is a chemical which counteracts or suppresses inflammation but which is not a steroid.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Condition in which the main influencing factor is a non-steroidal anti-inflammatory drug with chemical formula C15H12ClNO2, used as a veterinary analgesic.
jesmith
2017-02-22T18:45:59Z
CHEBI:364453
experimental_condition_ontology
XCO:0000507
carprofen
XCO:0000507
Condition in which the main influencing factor is a non-steroidal anti-inflammatory drug with chemical formula C15H12ClNO2, used as a veterinary analgesic.
https://en.wikipedia.org/wiki/Carprofen
An auditory stimulus consisting of a sound which is at a frequency and level to be perceptible to the ear, especially the human ear.
jesmith
2017-02-22T18:56:06Z
experimental_condition_ontology
XCO:0000508
audible tone stimulus
XCO:0000508
An auditory stimulus consisting of a sound which is at a frequency and level to be perceptible to the ear, especially the human ear.
Farlex:Farlex_Partner_Medical_Dictionary_2012
Mosby:Mosbys_Medical_Dictionary--8th_Ed
An auditory stimulus consisting of sound waves which are beyond the upper limit of perception by the human ear.
jesmith
2017-02-22T19:03:06Z
experimental_condition_ontology
XCO:0000509
ultrasonic stimulus
XCO:0000509
An auditory stimulus consisting of sound waves which are beyond the upper limit of perception by the human ear.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
An experimental condition characterized by rotation or twisting of the head parallel to the coronal plane of the body (that is, the plane which separates the belly from the back of the organism) at a relatively constant velocity.
jesmith
2017-04-21T13:27:10Z
experimental_condition_ontology
coronal plane angular velocity of the head
XCO:0000510
coronal plane rotational velocity of the head
XCO:0000510
An experimental condition characterized by rotation or twisting of the head parallel to the coronal plane of the body (that is, the plane which separates the belly from the back of the organism) at a relatively constant velocity.
PMID:27188340
Any condition in which the main influencing factor is a substance is a chemical compound derived from the linkage of an organic or inorganic acid and an alcohol, phenol, heteroarenol, or enol with the loss of water (H2O) formed from one hydrogen derived from an acidic hydroxy group of the acid and an -OH (hydroxy) group of the alcohol.
jesmith
2017-07-18T12:56:04Z
CHEBI:35701
experimental_condition_ontology
XCO:0000511
ester
XCO:0000511
Any condition in which the main influencing factor is a substance is a chemical compound derived from the linkage of an organic or inorganic acid and an alcohol, phenol, heteroarenol, or enol with the loss of water (H2O) formed from one hydrogen derived from an acidic hydroxy group of the acid and an -OH (hydroxy) group of the alcohol.
https://en.wikipedia.org/wiki/Ester
Any condition in which the main influencing factor is a substance with adverse or toxic effects on an embryo or fetus resulting in birth defects, specifically, altered development, growth retardation, functional defect and/or embryo death.
jesmith
2017-07-18T12:58:04Z
CHEBI:50905
teratogenic agent
experimental_condition_ontology
XCO:0000512
teratogen
XCO:0000512
Any condition in which the main influencing factor is a substance with adverse or toxic effects on an embryo or fetus resulting in birth defects, specifically, altered development, growth retardation, functional defect and/or embryo death.
https://en.wikipedia.org/wiki/Teratology
A condition in which the main influencing factor is dibutyl phthalate (DBP), the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. DBP has been used as a plasticizer and as an antiparasitic drug used to treat infestation of parasites on the surface of the body, and is suspected of being an endocrine disruptor and teratogen.
jesmith
2017-07-18T13:00:07Z
CHEBI:34687
di-n-butyl phthalate
experimental_condition_ontology
DBP
XCO:0000513
dibutyl phthalate
XCO:0000513
A condition in which the main influencing factor is dibutyl phthalate (DBP), the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. DBP has been used as a plasticizer and as an antiparasitic drug used to treat infestation of parasites on the surface of the body, and is suspected of being an endocrine disruptor and teratogen.
https://en.wikipedia.org/wiki/Dibutyl_phthalate
A condition in which the main influencing factor is metoprolol, a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches.
jesmith
2017-07-18T13:05:03Z
MESH:D008790
experimental_condition_ontology
XCO:0000514
metoprolol
XCO:0000514
A condition in which the main influencing factor is metoprolol, a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches.
MESH:D008790
https://en.wikipedia.org/wiki/Metoprolol
A condition in which the main influencing factor is metoprolol tartrate, an immediate-release formulation of metoprolol. Metoprolol is a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches.
jesmith
2017-07-18T13:06:13Z
experimental_condition_ontology
XCO:0000515
metoprolol tartrate
XCO:0000515
A condition in which the main influencing factor is metoprolol tartrate, an immediate-release formulation of metoprolol. Metoprolol is a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches.
MESH:D008790
https://en.wikipedia.org/wiki/Metoprolol
A condition in which the main influencing factor is metoprolol succinate, an extended-release formulation of metoprolol. Metoprolol is a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches.
jesmith
2017-07-18T13:06:16Z
experimental_condition_ontology
XCO:0000516
metoprolol succinate
XCO:0000516
A condition in which the main influencing factor is metoprolol succinate, an extended-release formulation of metoprolol. Metoprolol is a selective beta-1 adrenergic receptor blocker used to treat hypertension, angina, acute myocardial infarction, tachycardia, and congestive heart failure, and to prevent migraine headaches.
MESH:D008790
https://en.wikipedia.org/wiki/Metoprolol
A condition in which the main influencing factor is an immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with any or all of the transforming growth factor beta cytokines.
jesmith
2017-07-18T13:10:24Z
1D11 monoclonal antibody
experimental_condition_ontology
anti-TGFbeta antibody
XCO:0000517
anti-transforming growth factor beta antibody
XCO:0000517
A condition in which the main influencing factor is an immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with any or all of the transforming growth factor beta cytokines.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
A condition in which the main influencing factor is an immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with the beta subunit of Shiga toxin from Shigella dysenteriae 1.
jesmith
2017-07-18T13:12:49Z
experimental_condition_ontology
anti-Shigatoxin 1B antibody
XCO:0000518
anti-Shiga toxin 1 beta antibody
XCO:0000518
A condition in which the main influencing factor is an immunoglobulin molecule or a preparation of multiple antibody molecules having specific amino acid sequences with the ability to adhere to and interact specifically with the beta subunit of Shiga toxin from Shigella dysenteriae 1.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
PMID:26904753
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
A condition in which the main influencing factor is an immunoglobulin molecule having specific amino acid sequences with the ability to adhere to and interact specifically with the beta subunit of Shiga toxin from Shigella dysenteriae 1. This monoclonal antibody has been used as an IgG1 isotype control.
jesmith
2017-07-18T13:14:54Z
experimental_condition_ontology
anti-Shigatoxin 1B monoclonal antibody 13C4
XCO:0000519
anti-Shiga toxin 1 beta monoclonal antibody 13C4
XCO:0000519
A condition in which the main influencing factor is an immunoglobulin molecule having specific amino acid sequences with the ability to adhere to and interact specifically with the beta subunit of Shiga toxin from Shigella dysenteriae 1. This monoclonal antibody has been used as an IgG1 isotype control.
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
PMID:14675041
PMID:26904753
Saunders:Saunders_Comprehensive_Veterinary_Dictionary--3rd_Ed
Any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body.
jesmith
2017-07-18T13:25:13Z
experimental_condition_ontology
XCO:0000520
neuromodulation
XCO:0000520
Any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body.
https://en.wikipedia.org/wiki/Neuromodulation_(medicine)
This is any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly to a specific nerve or nerves, for example through the use of microelectrodes or an implanted device.
jesmith
2017-07-18T13:25:52Z
experimental_condition_ontology
direct electrical nerve stimulus
XCO:0000521
direct electrical nerve stimulation
XCO:0000521
This is any condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly to a specific nerve or nerves, for example through the use of microelectrodes or an implanted device.
https://en.wikipedia.org/wiki/Neurostimulation
A condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly the common peroneal nerve(s), for example through the use of microelectrodes or an implanted device. The common peroneal nerve is one of the terminal divisions of the sciatic nerve, diverging from the tibial nerve at the upper end of the popliteal fossa, then coursing with the biceps tendon along the lateral portion of the popliteal space to wind around the neck of the fibula, where it divides into the superficial and deep peroneal nerves.
jesmith
2017-07-18T13:27:01Z
direct electrical stimulus of the common peroneal nerve
experimental_condition_ontology
XCO:0000522
common peroneal nerve direct electrical stimulation
XCO:0000522
A condition in which the main influencing factor is the alteration of nerve activity through targeted delivery of an electrical stimulus directly the common peroneal nerve(s), for example through the use of microelectrodes or an implanted device. The common peroneal nerve is one of the terminal divisions of the sciatic nerve, diverging from the tibial nerve at the upper end of the popliteal fossa, then coursing with the biceps tendon along the lateral portion of the popliteal space to wind around the neck of the fibula, where it divides into the superficial and deep peroneal nerves.
Farlex:Farlex_Partner_Medical_Dictionary_2012
https://en.wikipedia.org/wiki/Common_peroneal_nerve
https://en.wikipedia.org/wiki/Neurostimulation
This is any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of an enzyme, a protein that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions.
jesmith
2017-07-18T13:31:10Z
experimental_condition_ontology
XCO:0000523
enzyme inhibitor
XCO:0000523
This is any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of an enzyme, a protein that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
Any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of angiotensin converting enzyme (ACE). ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. ACE inhibitors are used in the treatment of hypertension, congestive heart failure, acute myocardial infarction and diabetic nephropathy.
jesmith
2017-07-18T13:32:02Z
experimental_condition_ontology
ACE inhibitor
XCO:0000524
angiotensin converting enzyme inhibitor
XCO:0000524
Any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of angiotensin converting enzyme (ACE). ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. ACE inhibitors are used in the treatment of hypertension, congestive heart failure, acute myocardial infarction and diabetic nephropathy.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
https://en.wikipedia.org/wiki/ACE_inhibitor
A condition in which the main influencing factor is benazepril, a benzazepine in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety of benazeprilat has been converted to the corresponding ethyl ester. Removal of the ester by the liver converts the prodrug back to its active form, benazeprilat. Benazepril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, acute myocardial infarction and diabetic nephropathy.
jesmith
2017-07-18T13:34:04Z
CHEBI:3011
experimental_condition_ontology
XCO:0000525
benazepril
XCO:0000525
A condition in which the main influencing factor is benazepril, a benzazepine in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety of benazeprilat has been converted to the corresponding ethyl ester. Removal of the ester by the liver converts the prodrug back to its active form, benazeprilat. Benazepril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension, congestive heart failure, acute myocardial infarction and diabetic nephropathy.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
https://en.wikipedia.org/wiki/Benazepril
A condition in which the main influencing factor is the action of moving one's appendages to propel oneself through water while carrying weights (for example, aquatic dumbbells, ankle cuffs, or weighted belt) to increase resistance and/or decrease buoyancy thereby increasing the difficulty of the action.
jesmith
2017-07-18T13:50:19Z
experimental_condition_ontology
XCO:0000526
swimming with water weights
XCO:0000526
A condition in which the main influencing factor is the action of moving one's appendages to propel oneself through water while carrying weights (for example, aquatic dumbbells, ankle cuffs, or weighted belt) to increase resistance and/or decrease buoyancy thereby increasing the difficulty of the action.
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--5th_Ed
Encarta:Encarta_World_English_Dictionary
A condition in which the genotype or the gene expression of an organism or a cell has been modified.
jesmith
2017-08-11T16:51:14Z
experimental_condition_ontology
XCO:0000527
genetic manipulation
XCO:0000527
A condition in which the genotype or the gene expression of an organism or a cell has been modified.
Farlex:Farlex_Partner_Medical_Dictionary_2009
A condition in which copies of an exogenous gene have been (transiently or stably) inserted into a living cell or organism in order to induce synthesis of that gene's product.
jesmith
2017-08-11T16:57:10Z
experimental_condition_ontology
horizontal gene transfer
XCO:0000528
gene transfer
XCO:0000528
A condition in which copies of an exogenous gene have been (transiently or stably) inserted into a living cell or organism in order to induce synthesis of that gene's product.
Webster:Random_House_Kernerman_Websters_College_Dictionary_2010
A condition in which gene transfer has been performed using an adenovirus as the carrier of the genetic material. An adenovirus is any of a group of medium-sized (90-100 nm) non-enveloped icosahedral viruses of the family Adenoviridae which are characterized by a nucleocapsid surrounding a double-stranded DNA genome.
jesmith
2017-08-11T16:58:54Z
adenoviral gene transfer
adenovirus transfer
experimental_condition_ontology
XCO:0000529
gene transfer using adenovirus vector
XCO:0000529
A condition in which gene transfer has been performed using an adenovirus as the carrier of the genetic material. An adenovirus is any of a group of medium-sized (90-100 nm) non-enveloped icosahedral viruses of the family Adenoviridae which are characterized by a nucleocapsid surrounding a double-stranded DNA genome.
Segen:Segens_Medical_Dictionary_2012
A condition in which the mouse angiotensin I converting enzyme 2 (Ace2) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
jesmith
2017-08-11T17:15:29Z
MGI:1917258
RGD:1550521
adenoviral transfer of the murine Ace2 gene
transfer of recombinant adenovirus containing the murine Ace2 gene
experimental_condition_ontology
Ad-Ace2
XCO:0000530
gene transfer of the murine angiotensin I converting enzyme 2 gene using an adenovirus vector
XCO:0000530
A condition in which the mouse angiotensin I converting enzyme 2 (Ace2) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
RGD:12879447
Webster:Random_House_Kernerman_Websters_College_Dictionary_2010
A condition in which the enhanced green fluorescent protein (EGFP) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
jesmith
2017-08-11T17:17:27Z
adenoviral transfer of the EGFP gene
transfer of recombinant adenovirus containing the EGFP gene
experimental_condition_ontology
Ad-EGFP
XCO:0000531
gene transfer of the enhanced green fluorescent protein gene using an adenovirus vector
XCO:0000531
A condition in which the enhanced green fluorescent protein (EGFP) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
RGD:12879447
Webster:Random_House_Kernerman_Websters_College_Dictionary_2010
Any condition in which the main influencing factor is a substance which disrupts one or more of the processes that lead directly to the generation of new proteins, that is, that inhibits the process of translation of mRNAs into proteins.
jesmith
2017-08-11T17:21:03Z
experimental_condition_ontology
XCO:0000532
protein synthesis inhibitor
XCO:0000532
Any condition in which the main influencing factor is a substance which disrupts one or more of the processes that lead directly to the generation of new proteins, that is, that inhibits the process of translation of mRNAs into proteins.
https://en.wikipedia.org/wiki/Protein_synthesis_inhibitor
Condition in which the main influencing factor is puromycin, an aminonucleoside antibiotic derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome.
jesmith
2017-08-11T17:21:54Z
CHEBI:17939
experimental_condition_ontology
XCO:0000533
puromycin
XCO:0000533
Condition in which the main influencing factor is puromycin, an aminonucleoside antibiotic derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome.
https://en.wikipedia.org/wiki/Puromycin
A condition in which the main influencing factor is sunitinib, an antineoplastic agent which acts as a receptor tyrosine kinase inhibitor and an antagonist for multiple platelet-derived growth factor and vascular endothelial growth factor receptors. Sunitinib is used as a chemotherapy agent in the treatment of renal cell carcinoma and gastrointestinal stromal tumor.
jesmith
2017-08-11T17:28:23Z
CHEBI:38940
experimental_condition_ontology
Sutent
sunitinibum
XCO:0000534
sunitinib
XCO:0000534
A condition in which the main influencing factor is sunitinib, an antineoplastic agent which acts as a receptor tyrosine kinase inhibitor and an antagonist for multiple platelet-derived growth factor and vascular endothelial growth factor receptors. Sunitinib is used as a chemotherapy agent in the treatment of renal cell carcinoma and gastrointestinal stromal tumor.
https://en.wikipedia.org/wiki/Sunitinib
A condition in which the main influencing factor is lisinopril, an antihypertensive competitive inhibitor of angiotensin-converting enzyme (ACE).
jrsmith
2018-05-11T10:54:07Z
experimental_condition_ontology
Prinivil
Qbrelis
Zestril
XCO:0000535
lisinopril
XCO:0000535
A condition in which the main influencing factor is lisinopril, an antihypertensive competitive inhibitor of angiotensin-converting enzyme (ACE).
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
ISBN:978-1416049982
This is any condition in which the main influencing factor is an angiotensin II receptor antagonist, an agent that blocks angiotensin II receptors and is used to treat high blood pressure and heart failure.
jrsmith
2018-05-14T18:01:31Z
ARB
angiotensin II receptor blocker
angiotensin receptor blocker
sartan
experimental_condition_ontology
XCO:0000536
angiotensin II receptor antagonist
XCO:0000536
This is any condition in which the main influencing factor is an angiotensin II receptor antagonist, an agent that blocks angiotensin II receptors and is used to treat high blood pressure and heart failure.
https://en.wikipedia.org/wiki/Angiotensin_II_receptor_blocker
This is any condition in which the main influencing factor is olmesartan medoxomil, an angiotensin II receptor blocker which is used as an antihypertensive agent.
jrsmith
2018-05-14T18:27:28Z
experimental_condition_ontology
CS-866
XCO:0000537
olmesartan medoxomil
XCO:0000537
This is any condition in which the main influencing factor is olmesartan medoxomil, an angiotensin II receptor blocker which is used as an antihypertensive agent.
https://en.wikipedia.org/wiki/Olmesartan
An experimental condition in which the main influencing factor is temocapril, an angiotensin-I converting enzyme (ACE) inhibitor consisting of a dipeptide prodrug with a thiazepine ring.
jrsmith
2018-05-14T18:34:03Z
alpha-((2S,6R)-6-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl)acetic acid.HCl
experimental_condition_ontology
Acecol
CS-622
CS622
XCO:0000538
temocapril
XCO:0000538
An experimental condition in which the main influencing factor is temocapril, an angiotensin-I converting enzyme (ACE) inhibitor consisting of a dipeptide prodrug with a thiazepine ring.
https://en.wikipedia.org/wiki/Temocapril
An experimental condition in which the main influencing factor is doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
jrsmith
2018-05-15T15:54:18Z
CHEBI:28748
ADR
Adriablastine
DXR
adriamycin
experimental_condition_ontology
XCO:0000539
doxorubicin
XCO:0000539
An experimental condition in which the main influencing factor is doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
drugbank:DB00997
https://en.wikipedia.org/wiki/Doxorubicin
An experimental condition in which the main influencing factor is delapril, an antihypertensive prodrug that, when converted to its active metabolites 5-hydroxy delapril diacid and delapril diacid, acts as an angiotensin-converting enzyme (ACE) inhibitor.
jrsmith
2018-05-15T15:58:32Z
CHEBI:135735
experimental_condition_ontology
XCO:0000540
delapril
XCO:0000540
An experimental condition in which the main influencing factor is delapril, an antihypertensive prodrug that, when converted to its active metabolites 5-hydroxy delapril diacid and delapril diacid, acts as an angiotensin-converting enzyme (ACE) inhibitor.
https://en.wikipedia.org/wiki/Delapril
An experimental condition in which the main influencing factor is bosentan, a competitive antagonist of endothelin-1 that blocks the binding of endothelin to both the endothelin-A (ET-A) and endothelin-B (ET-B)receptors. Bosentan is used in the treatment of pulmonary arterial hypertension.
jrsmith
2018-05-15T16:06:25Z
experimental_condition_ontology
Tracleer
bosentanum
XCO:0000541
bosentan
XCO:0000541
An experimental condition in which the main influencing factor is bosentan, a competitive antagonist of endothelin-1 that blocks the binding of endothelin to both the endothelin-A (ET-A) and endothelin-B (ET-B)receptors. Bosentan is used in the treatment of pulmonary arterial hypertension.
https://en.wikipedia.org/wiki/Bosentan
https://phassociation.org/patients/treatments/bosentan/
An experimental condition in which the main influencing factor is enalapril, a prodrug that is rapidly metabolized in the liver to enalaprilat, a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
jrsmith
2018-05-15T16:09:53Z
experimental_condition_ontology
Enacard
Renitec
Vasotec
XCO:0000542
enalapril
XCO:0000542
An experimental condition in which the main influencing factor is enalapril, a prodrug that is rapidly metabolized in the liver to enalaprilat, a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
https://en.wikipedia.org/wiki/Enalapril
A condition in which the main influencing factor is one or more closely related forms (vitamers) of vitamin D, a group of fat-soluble secosteroid vitamins (when ingested from dietary sources) and/or hormones (when produced by the skin in response to ultraviolet radiation). Vitamin D is involved in intestinal absorption of calcium, magnesium and phosphate, and in calcium homeostasis and metabolism.
jrsmith
2018-05-15T16:17:43Z
experimental_condition_ontology
XCO:0000543
vitamin D
XCO:0000543
A condition in which the main influencing factor is one or more closely related forms (vitamers) of vitamin D, a group of fat-soluble secosteroid vitamins (when ingested from dietary sources) and/or hormones (when produced by the skin in response to ultraviolet radiation). Vitamin D is involved in intestinal absorption of calcium, magnesium and phosphate, and in calcium homeostasis and metabolism.
https://en.wikipedia.org/wiki/Vitamin_D
An experimental condition in which the main influencing factor is vitamin D2, a type of vitamin D found in food and used as a dietary supplement. The D2 vitamer has been found to be less efficiently absorbed in the human intestine and/or less biologically active than the D3 vitamer.
jrsmith
2018-05-15T16:22:22Z
calciferol
ergocalciferol
experimental_condition_ontology
Calcidol
Drisdol
XCO:0000544
vitamin D2
XCO:0000544
An experimental condition in which the main influencing factor is vitamin D2, a type of vitamin D found in food and used as a dietary supplement. The D2 vitamer has been found to be less efficiently absorbed in the human intestine and/or less biologically active than the D3 vitamer.
PMID:22552031
https://en.wikipedia.org/wiki/Ergocalciferol
An experimental condition in which the main influencing factor is vitamin D3, a form of vitamin D which is naturally synthesized in the skin of animals by the action of ultraviolet B (UVB) radiation on 7-dehydrocholesterol. Vitamin D3 is also found in some foods and can be used as a dietary supplement. The D3 vitamer has been found to be more efficiently absorbed in the human intestine and/or more biologically active than the D2 vitamer.
jrsmith
2018-05-15T16:35:39Z
cholecalciferol
colecalciferol
experimental_condition_ontology
XCO:0000545
vitamin D3
XCO:0000545
An experimental condition in which the main influencing factor is vitamin D3, a form of vitamin D which is naturally synthesized in the skin of animals by the action of ultraviolet B (UVB) radiation on 7-dehydrocholesterol. Vitamin D3 is also found in some foods and can be used as a dietary supplement. The D3 vitamer has been found to be more efficiently absorbed in the human intestine and/or more biologically active than the D2 vitamer.
PMID:22552031
https://en.wikipedia.org/wiki/Cholecalciferol
A condition in which the main influencing factor is a compound with structural and/or functional similarity to a vitamin and can therefore be substituted for the analogous vitamin.
jrsmith
2018-05-15T16:41:42Z
vitamin analogue
experimental_condition_ontology
XCO:0000546
vitamin analog
XCO:0000546
A condition in which the main influencing factor is a compound with structural and/or functional similarity to a vitamin and can therefore be substituted for the analogous vitamin.
https://en.wikipedia.org/wiki/Analog
An experimental condition in which the main influencing factor is paricalcitol, an analog of vitamin D2 used for the prevention and treatment of secondary hyperparathyroidism.
jrsmith
2018-05-15T16:44:29Z
19-nor-1,25-(OH)2-vitamin D2
experimental_condition_ontology
Zemplar
XCO:0000547
paricalcitol
XCO:0000547
An experimental condition in which the main influencing factor is paricalcitol, an analog of vitamin D2 used for the prevention and treatment of secondary hyperparathyroidism.
https://en.wikipedia.org/wiki/Paricalcitol
An experimental condition in which the main influencing factor is ramipril, a prodrug that is metabolized in the liver to ramiprilat, a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
jrsmith
2018-05-15T16:51:40Z
CHEBI:8774
Altace
Tritace
experimental_condition_ontology
XCO:0000548
ramipril
XCO:0000548
An experimental condition in which the main influencing factor is ramipril, a prodrug that is metabolized in the liver to ramiprilat, a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
MESH:D017257
drugbank:DB00178
A surgical manipulation causing blockage of the left anterior descending coronary artery, the artery supplying blood to approximately half of the left ventricle of the heart including the anterolateral myocardium, apex, and interventricular septum.
jrsmith
2018-05-15T16:57:52Z
left coronary artery ligation
experimental_condition_ontology
LAD blockage
LAD occlusion
widow maker occlusion
XCO:0000549
left anterior descending coronary artery occlusion
XCO:0000549
A surgical manipulation causing blockage of the left anterior descending coronary artery, the artery supplying blood to approximately half of the left ventricle of the heart including the anterolateral myocardium, apex, and interventricular septum.
https://en.wikipedia.org/wiki/Anterior_interventricular_branch_of_left_coronary_artery
An experimental condition in which the main influencing factor is reserpine, an indole alkaloid which irreversibly blocks the vesicular monoamine transporters (VMATs), SLC18A1 and SLC18A2. Reserpine has been used as both an antihypertensive drug and an antipsychotic drug.
jrsmith
2018-05-15T17:19:06Z
CHEBI:28487
MESH:D012110
Serpasil
methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
experimental_condition_ontology
XCO:0000550
reserpine
XCO:0000550
An experimental condition in which the main influencing factor is reserpine, an indole alkaloid which irreversibly blocks the vesicular monoamine transporters (VMATs), SLC18A1 and SLC18A2. Reserpine has been used as both an antihypertensive drug and an antipsychotic drug.
PMID:7905859
drugbank:DB00206
https://en.wikipedia.org/wiki/Reserpine
An experimental condition in which the main influencing factor is hydralazine, a vasodilator that appears to have multiple, direct effects on smooth muscles of the arterial vessels, thereby reducing systemic vascular resistance and arterial pressure.
jrsmith
2018-05-15T17:22:47Z
experimental_condition_ontology
XCO:0000551
hydralazine
XCO:0000551
An experimental condition in which the main influencing factor is hydralazine, a vasodilator that appears to have multiple, direct effects on smooth muscles of the arterial vessels, thereby reducing systemic vascular resistance and arterial pressure.
drugbank:DB01275
http://cvpharmacology.com/vasodilator/direct
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of hydralazine in which the amount of hydralazine consumed is maintained at a specified level.
jrsmith
2018-05-15T17:24:24Z
CHEBI:5775
PMID:3611778
experimental_condition_ontology
XCO:0000552
controlled hydralazine content drinking water
XCO:0000552
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of hydralazine in which the amount of hydralazine consumed is maintained at a specified level.
MESH:D006830
https://www.merriam-webster.com/
An experimental condition in which the main influencing factor is everolimus, a mammalian target of rapamycin (mTOR) inhibitor which is selective for the mTORC1 protein complex, with little or no effect on mTORC2. Everolimus is used as an antineoplastic and immunosuppressive agent.
jrsmith
2018-05-31T13:41:07Z
CHEBI:68478
experimental_condition_ontology
XCO:0000553
everolimus
XCO:0000553
An experimental condition in which the main influencing factor is everolimus, a mammalian target of rapamycin (mTOR) inhibitor which is selective for the mTORC1 protein complex, with little or no effect on mTORC2. Everolimus is used as an antineoplastic and immunosuppressive agent.
https://en.wikipedia.org/wiki/Everolimus
A regimen of solid food in which the amount of phosphorus consumed is controlled.
sjwang
2018-11-14T15:58:10Z
experimental_condition_ontology
XCO:0000554
controlled phosphorus content diet
XCO:0000554
A drink made up of water and a specified amount of lisinopril consumed by an organism as part of an experiment.
sjwang
2018-11-14T16:04:27Z
experimental_condition_ontology
XCO:0000555
controlled lisinopril content drinking water
XCO:0000555
Any amino sugar that is a monosaccharide in which one alcoholic hydroxy group is replaced by an amino group.
sjwang
2018-11-16T10:50:55Z
CHEBI:60926
experimental_condition_ontology
XCO:0000556
amino monosaccharide
XCO:0000556
Glucosamine, commonly used as a treatment for osteoarthritis, is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.
sjwang
2018-11-16T10:55:31Z
2-amino-2-deoxyglucose
experimental_condition_ontology
XCO:0000557
glucosamine
XCO:0000557
Glucosamine, commonly used as a treatment for osteoarthritis, is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.
drugbank:DB01296
Taxifolin is a flavanonol and a non-steroidal anti-inflammatory agent.
sjwang
2018-11-16T11:03:16Z
CHEBI:38747
DHQ
Distylin
Taxifoliol
catechin hydrate
dihydroquercetin
experimental_condition_ontology
XCO:0000558
taxifolin
XCO:0000558
Taxifolin is a flavanonol and a non-steroidal anti-inflammatory agent.
https://en.wikipedia.org/wiki/Taxifolin
A biogenic amine that is found in animals and plants. In mammals, melatonin is a hormone produced by the pineal gland. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of sleep, mood, and reproduction. Melatonin is also an effective antioxidant.
sjwang
2018-11-19T14:33:05Z
CHEBI:16796
experimental_condition_ontology
XCO:0000559
melatonin
XCO:0000559
A biogenic amine that is found in animals and plants. In mammals, melatonin is a hormone produced by the pineal gland. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of sleep, mood, and reproduction. Melatonin is also an effective antioxidant.
https://druginfo.nlm.nih.gov/drugportal/name/melatonin
https://meshb.nlm.nih.gov/record/ui?ui=D008550
A solid diet in which the amount of melatonin is maintained at a specified level.
sjwang
2018-11-19T14:48:04Z
experimental_condition_ontology
XCO:0000560
controlled melatonin content diet
XCO:0000560
This is any condition in which the main influencing factor is an antidepressant, a mood-stimulating drug used primarily in the treatment of affective disorders and related conditions.
sjwang
2018-11-21T09:51:04Z
MESH:D000928
experimental_condition_ontology
XCO:0000561
antidepressant
XCO:0000561
This is any condition in which the main influencing factor is an antidepressant, a mood-stimulating drug used primarily in the treatment of affective disorders and related conditions.
CHEBI:35469
This is any condition in which the main influencing factor is salidroside, a glucoside of tyrosol found in the plant Rhodiola rosea. It is thought to be one of the compounds responsible for the antidepressant and anxiolytic actions of this plant.
sjwang
2018-11-21T09:53:27Z
CHEBI:9009
MESH:C009172
2-(4-Hydroxyphenyl)ethyl β-D-glucopyranoside
rhodioloside
rhodosin
sallidroside
tyrosol glucoside
experimental_condition_ontology
XCO:0000562
salidroside
XCO:0000562
This is any condition in which the main influencing factor is salidroside, a glucoside of tyrosol found in the plant Rhodiola rosea. It is thought to be one of the compounds responsible for the antidepressant and anxiolytic actions of this plant.
https://druginfo.nlm.nih.gov/drugportal/name/salidroside
OMACOR is a prescription medicine for adults called a lipid-regulating medicine. It is a mix of docosahexaenoic acid [DHA] (~ 50%) + eicosapentaenoic acid [EPA] (~40%) ethylesters.
sjwang
2018-11-27T13:04:58Z
Lovaza
Omega-3-Acid Ethyl Esters (eicosapentaenoic acid and docosahexaenoic acid)
Omytrg
experimental_condition_ontology
XCO:0000563
Omacor
XCO:0000563
OMACOR is a prescription medicine for adults called a lipid-regulating medicine. It is a mix of docosahexaenoic acid [DHA] (~ 50%) + eicosapentaenoic acid [EPA] (~40%) ethylesters.
https://www.nlm.nih.gov/medlineplus/
A member of the anthranilic acid derivatives class of NSAID drug used for joint, muscular pain, arthritis and dysmenorrhea.
sjwang
2018-11-27T14:31:01Z
experimental_condition_ontology
XCO:0000564
meclofenamate
XCO:0000564
A member of the anthranilic acid derivatives class of NSAID drug used for joint, muscular pain, arthritis and dysmenorrhea.
https://en.wikipedia.org/wiki/Meclofenamic_acid
A pharmaceutical drug for treatment of type 2 diabetes. Ipragliflozin reduces blood glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2.
sjwang
2018-11-30T14:59:25Z
experimental_condition_ontology
XCO:0000565
ipragliflozin
XCO:0000565
A pharmaceutical drug for treatment of type 2 diabetes. Ipragliflozin reduces blood glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2.
https://en.wikipedia.org/wiki/Ipragliflozin
A solid diet in which the amount of ipragliflozin, an oral antidiabetic drug, is maintained at a specified level.
sjwang
2018-11-30T15:02:35Z
experimental_condition_ontology
XCO:0000566
controlled ipragliflozin content diet
XCO:0000566
sjwang
2018-12-05T14:02:20Z
experimental_condition_ontology
XCO:0000567
adrenomedulin
XCO:0000567
A vasodilator and an antioxidant. It relaxes arteries and inhibits membrane-bound enzymes that form reactive oxygen species, such as superoxides.
sjwang
2018-12-05T14:06:11Z
experimental_condition_ontology
XCO:0000568
hydralazine hydrochloride
XCO:0000568
sjwang
2018-12-05T14:21:28Z
experimental_condition_ontology
XCO:0000569
controlled hydralazine hydrochloride content drinking water
XCO:0000569
A selective and competitive arginine vasopressin receptor 2 antagonist.
sjwang
2018-12-05T14:25:32Z
experimental_condition_ontology
XCO:0000570
tolvaptan
XCO:0000570
sjwang
2018-12-05T14:27:59Z
experimental_condition_ontology
XCO:0000571
controlled tolvaptan content diet
XCO:0000571
This is any condition in which the main influencing factor is vancomycin, a complex glycopeptide from Streptomyces orientalis. Vancomycin inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.
sjwang
2018-12-05T14:37:41Z
MESH:D014640
experimental_condition_ontology
XCO:0000572
vancomycin
XCO:0000572
This is any condition in which the main influencing factor is vancomycin, a complex glycopeptide from Streptomyces orientalis. Vancomycin inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.
CHEBI:28001
sjwang
2018-12-05T14:41:59Z
experimental_condition_ontology
XCO:0000573
null
true
XCO:0000573
sjwang
2018-12-05T14:42:50Z
experimental_condition_ontology
XCO:0000574
controlled vancomycin content drinking water
XCO:0000574
Meropenem is a broad-spectrum antibiotic used to treat a variety of bacterial infections.
sjwang
2018-12-05T15:07:54Z
CHEBI:43968
MESH:D000077731
3-(5-Dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
Merrem
Merrem Novaplus
Penem
Ronem
SM 7338
experimental_condition_ontology
XCO:0000575
meropenem
XCO:0000575
Meropenem is a broad-spectrum antibiotic used to treat a variety of bacterial infections.
https://en.wikipedia.org/wiki/Meropenem
sjwang
2018-12-05T15:12:42Z
experimental_condition_ontology
XCO:0000576
controlled meropenem content drinking water
XCO:0000576
Proton pump inhibitors (PPIs) reduce the production of acid by blocking H+/K+ ATPase in the wall of the stomach.
sjwang
2018-12-05T15:17:00Z
Synonym: PPI
experimental_condition_ontology
XCO:0000577
proton pump inhibitor
XCO:0000577
This is any condition in which the main influencing factor is omeprazole, a highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome.
sjwang
2018-12-05T15:19:50Z
CHEBI:7772
CID:4594
rac-5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
experimental_condition_ontology
XCO:0000578
omeprazole
XCO:0000578
This is any condition in which the main influencing factor is omeprazole, a highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome.
MESH:D009853
Any experimental condition in which the internal or external environment of the gastrointestinal system is altered.
sjwang
2018-12-05T15:24:01Z
experimental_condition_ontology
XCO:0000579
controlled in situ gastrointestinal condition
XCO:0000579
Any experimental condition in which the internal or external environment of the gastrointestinal system is altered.
ISBN-13:9780781733908
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is the administration of food or drug by force, especially to a laboratory animal, typically through a tube leading down the throat to the stomach.
sjwang
2018-12-05T15:43:29Z
gavage
experimental_condition_ontology
XCO:0000580
forced feeding
XCO:0000580
This is any condition in which the main influencing factor is the introduction of material, food, or drug into the stomach by a tube via the oral cavity.
sjwang
2018-12-05T15:45:21Z
XCO:0000582
XCO:0000583
XCO:0000584
controlled content oral gavage
controlled cecal material content oral gavage
controlled omeprazole content oral gavage
experimental_condition_ontology
XCO:0000581
oral gavage
XCO:0000581
Oral gavage in which the amount of one or more solutes are adjusted to a requirement.
sjwang
2018-12-05T15:49:29Z
experimental_condition_ontology
XCO:0000582
controlled content oral gavage
true
XCO:0000582
An oral gavage solution made up of solvent and a specified amount of omeprazole.
sjwang
2018-12-05T15:51:33Z
experimental_condition_ontology
XCO:0000583
controlled omeprazole content oral gavage
true
XCO:0000583
An oral gavage delivery made up of a specified amount of harvested cecal material.
sjwang
2018-12-05T15:55:37Z
experimental_condition_ontology
XCO:0000584
controlled cecal material content oral gavage
true
XCO:0000584
A control oligodeoxynucleotide with a non-specific scrambled sequence.
sjwang
2018-12-06T15:58:27Z
experimental_condition_ontology
SCR ODN
scrambled control ODN
XCO:0000585
scrambled control oligodeoxynucleotide
XCO:0000585
sjwang
2018-12-06T16:40:39Z
Gnai2 ODN
experimental_condition_ontology
Gαi2 ODN
Gαi2 oligodeoxynucleotide
Gnai2 AS-ODN
Gnai2 antisense oligodeoxynucleotide
XCO:0000586
Gnai2 antisense oligonucleotide
XCO:0000586
Stereotaxic implant with a stainless steel cannula into a cerebral ventricle, which can be connected via silastic tubing to a miniosmotic pump for chronic infusion.
sjwang
2018-12-06T16:45:37Z
experimental_condition_ontology
i.c.v. cannula implantation
XCO:0000587
intracerebroventricular cannula implantation
XCO:0000587
Stereotaxic implant with a stainless steel cannula into a cerebral ventricle, which can be connected via silastic tubing to a miniosmotic pump for chronic infusion.
PMID:25312437
Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, a potent, competitive inhibitor of ACE.
sjwang
2018-12-07T15:47:47Z
CHEBI:8024
MESH:D020913
PMID:12376396
Aceon
Coversum
Coversyl
ethyl N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvalinate
experimental_condition_ontology
XCO:0000588
perindopril
XCO:0000588
Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, a potent, competitive inhibitor of ACE.
drugbank:DB00790
A condition in which the main influencing factor is Moexipril, a non-sulfhydryl-containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor Moexiprilat and a vasodilatory antihypertensive drug.
sjwang
2018-12-07T16:00:47Z
experimental_condition_ontology
XCO:0000589
Moexipril
XCO:0000589
A synthetic decapeptide that is a bradykinin receptor antagonist used for the treatment of hereditary angioedema.
sjwang
2018-12-07T16:19:30Z
experimental_condition_ontology
XCO:0000590
icatibant
XCO:0000590
A prodrug that is metabolized to quinaprilat (quinapril diacid), a competitive inhibitor of angiotensin-converting enzyme (ACE).
sjwang
2018-12-07T16:22:09Z
experimental_condition_ontology
XCO:0000591
quinapril
XCO:0000591
A prodrug that is hydrolyzed to its main metabolite cilazaprilat, an inhibitor of angiotensin-converting enzyme (ACE).
sjwang
2018-12-20T15:23:56Z
Dynorm
Inhibace
Vascace
experimental_condition_ontology
XCO:0000592
cilazapril
XCO:0000592
The aminonucleoside portion of the antibiotic puromycin. NOTE: This molecule does not induce apoptosis and does not inhibit protein synthesis.
sjwang
2018-12-27T10:28:04Z
3'-Amino-3'-deoxy-N6,N6-dimethyladenosine
experimental_condition_ontology
XCO:0000593
puromycin aminonucleoside
XCO:0000593
This is any condition in which the main influencing factor is saralasin, a competitive angiotensin II receptor antagonist with partial agonistic activity previously used to distinguish renovascular hypertension from essential hypertension.
sjwang
2018-12-27T13:23:15Z
CHEBI:135894
CID:6324663
Sar-Arg-Val-Tyr-Val-His-Pro-Ala
experimental_condition_ontology
XCO:0000594
saralasin
XCO:0000594
This is any condition in which the main influencing factor is saralasin, a competitive angiotensin II receptor antagonist with partial agonistic activity previously used to distinguish renovascular hypertension from essential hypertension.
https://en.wikipedia.org/wiki/Saralasin
sjwang
2018-12-27T14:59:42Z
experimental_condition_ontology
XCO:0000595
surgical manipulation of blood vessels
XCO:0000595
This is any condition in which the main influencing factor is surgical narrowing of the lumen of a blood vessel. This lumen narrowing could be accomplished by circumferential suturing, use of a manipulatable sleeve, or some other method.
sjwang
2018-12-27T15:05:18Z
experimental_condition_ontology
XCO:0000596
blood vessel constriction
XCO:0000596
This is any condition in which the main influencing factor is surgical narrowing of the lumen of the abdominal aorta. The abdominal aorta consists of the suprarenal abdominal aorta and the infrarenal aorta.
sjwang
2018-12-27T15:08:06Z
AAC
abdominal aorta constriction
experimental_condition_ontology
XCO:0000597
abdominal aortic constriction
XCO:0000597
This is any condition in which the main influencing factor is surgical narrowing of the lumen of the abdominal aorta. The abdominal aorta consists of the suprarenal abdominal aorta and the infrarenal aorta.
PMID:28060255
This is any condition in which the main influencing factor is surgical narrowing of the lumen of the thoracic aorta. The thoracic aorta consists of the ascending aorta, the aortic arch, and the descending thoracic aorta.
sjwang
2018-12-27T15:10:16Z
thoracic aorta constriction
TAC
transverse aortic constriction
experimental_condition_ontology
XCO:0000598
thoracic aortic constriction
XCO:0000598
This is any condition in which the main influencing factor is surgical narrowing of the lumen of the thoracic aorta. The thoracic aorta consists of the ascending aorta, the aortic arch, and the descending thoracic aorta.
https://en.wikipedia.org/wiki/Aorta
A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure.
sjwang
2018-12-27T15:39:58Z
MESH:D000450
PMID:8770880
11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
experimental_condition_ontology
XCO:0000599
aldosterone
XCO:0000599
A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure.
CHEBI:27584
This is any condition in which the main influencing factor is 2,3,7,8-tetrachlorodibenzo-p-dioxin, a polychlorinated dibenzo-p-dioxin that activates the aryl hydrocarbon (AH) receptor, a transcription factor.
sjwang
2019-01-21T12:54:07Z
CHEBI:28119
CID:15625
2,3,7,8-Tetrachlorodibenzo[b,e][1,4]dioxine
2,3,7,8-tetrachlorooxanthrene
TCDD
tetrachlorodibenzo-p-dioxin
tetrachlorodibenzodioxin
tetradioxin
experimental_condition_ontology
XCO:0000600
2,3,7,8-tetrachlorodibenzo-p-dioxin
XCO:0000600
This is any condition in which the main influencing factor is 2,3,7,8-tetrachlorodibenzo-p-dioxin, a polychlorinated dibenzo-p-dioxin that activates the aryl hydrocarbon (AH) receptor, a transcription factor.
https://en.wikipedia.org/wiki/2,3,7,8-Tetrachlorodibenzodioxin
A condition in which the rat natriuretic peptide B gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
sjwang
2019-01-22T13:43:52Z
gene transfer of adenovirus-NPPB
gene transfer of the rat BNP gene using an adenovirus vector
gene transfer of the rat Nppb gene using an adenovirus vector
experimental_condition_ontology
XCO:0000601
gene transfer of the rat natriuretic peptide B gene using an adenovirus vector
XCO:0000601
A peroxisome proliferator-activated receptor gamma agonist; reduces lipid availability, improves insulin action & glucoregulation
sjwang
2019-01-22T13:55:58Z
CHEBI:50122
experimental_condition_ontology
XCO:0000602
rosiglitazone
XCO:0000602
A peroxisome proliferator-activated receptor gamma agonist; reduces lipid availability, improves insulin action & glucoregulation
https://druginfo.nlm.nih.gov/drugportal/name/rosiglitazone
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside Hesperidin, is the predominant flavonoid in lemons and oranges.
sjwang
2019-01-22T14:38:41Z
CHEBI:28230
MESH:C013015
experimental_condition_ontology
XCO:0000603
hesperetin
XCO:0000603
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside Hesperidin, is the predominant flavonoid in lemons and oranges.
drugbank:DB01094
Any condition in which the main influencing factor is Aprotinin, also known as bovine pancreatic trypsin inhibitor (BPTI), a proteinase inhibitor used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery.
sjwang
2019-02-15T16:27:32Z
C284H432N84O79S7
Trasylol
experimental_condition_ontology
XCO:0000604
Aprotinin
XCO:0000604
Any condition in which the main influencing factor is Aprotinin, also known as bovine pancreatic trypsin inhibitor (BPTI), a proteinase inhibitor used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery.
drugbank:DB06692
An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
sjwang
2019-02-26T11:26:05Z
experimental_condition_ontology
XCO:0000605
aflatoxin B1
XCO:0000605
An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
CHEBI:2504
AMG-8718 is the inhibitor of β-site amyloid precursor protein cleaving enzyme (BACE1).
sjwang
2019-03-18T16:27:59Z
experimental_condition_ontology
XCO:0000606
AMG-8718
XCO:0000606
AMG-8718 is the inhibitor of β-site amyloid precursor protein cleaving enzyme (BACE1).
PMID:25363711
This is any condition in which the main influencing factor is acetic acid, the product of the oxidation of ethanol and of the destructive distillation of wood. Acetic acid is used locally, occasionally internally, as a counterirritant and also as a reagent.
sjwang
2019-03-19T17:06:26Z
MESH:D019342
ethanoic acid
ethylic acid
methane carboxylic acid
vinegar acid
experimental_condition_ontology
XCO:0000607
acetic acid
XCO:0000607
This is any condition in which the main influencing factor is acetic acid, the product of the oxidation of ethanol and of the destructive distillation of wood. Acetic acid is used locally, occasionally internally, as a counterirritant and also as a reagent.
CHEBI:15366
Stedman:Stedmans_Medical_Dictionary_26th_ed
An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.
sjwang
2019-03-27T15:27:46Z
CHEBI:73224
pubchem.compound:5971
experimental_condition_ontology
MO
mustard oil
XCO:0000608
Allyl isothiocyanate
XCO:0000608
An isothiocyanate with the formula CH2=CHCH2N=C=S. A colorless oil with boiling point 152degreeC, it is responsible for the pungent taste of mustard, horseradish, and wasabi.
CHEBI:73224
A potent and selective blocker of TRPC4 channels.
sjwang
2019-03-27T15:43:10Z
CID:230710
4-methyl-2-(piperidin-1-yl)quinoline
4-methyl-2-piperidin-1-ylquinoline
ML-204
ML204
experimental_condition_ontology
XCO:0000609
4-methyl-2-(piperidin-1-yl)-quinoline
XCO:0000609
A potent and selective blocker of TRPC4 channels.
PMID:24388923
A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
sjwang
2019-03-27T15:52:55Z
CHEBI:17303
pubchem.compound:5288826
experimental_condition_ontology
XCO:0000610
morphine
XCO:0000610
A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
CHEBI:17303
This is any condition in which the main influencing factor is nifedipine, a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
sjwang
2019-04-22T16:41:50Z
CHEBI:7565
CID:4485
dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
experimental_condition_ontology
XCO:0000611
nifedipine
XCO:0000611
This is any condition in which the main influencing factor is nifedipine, a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
MESH:D009543
This is any condition in which the main influencing factor is endothelin-1, a 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production.
sjwang
2019-05-08T14:50:29Z
CHEBI:80240
CID:16212950
PMID:12070093
ET-1
Edn1
Et1
experimental_condition_ontology
XCO:0000612
endothelin-1
XCO:0000612
This is any condition in which the main influencing factor is endothelin-1, a 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production.
PMID:7609754
Adenosine Triphosphate (ATP) is an adenine nucleotide comprised of three phosphate groups esterified to the sugar moiety, found in all living cells. Adenosine triphosphate is involved in energy production for metabolic processes and RNA synthesis. In addition, this substance acts as a neurotransmitter. In cancer studies, adenosine triphosphate is synthesized to examine its use to decrease weight loss and improve muscle strength.
sjwang
2019-05-08T15:10:50Z
CHEBI:15422
pubchem.compound:5957
experimental_condition_ontology
XCO:0000613
Adenosine triphosphate
XCO:0000613
Adenosine Triphosphate (ATP) is an adenine nucleotide comprised of three phosphate groups esterified to the sugar moiety, found in all living cells. Adenosine triphosphate is involved in energy production for metabolic processes and RNA synthesis. In addition, this substance acts as a neurotransmitter. In cancer studies, adenosine triphosphate is synthesized to examine its use to decrease weight loss and improve muscle strength.
https://ncit.nci.nih.gov/ncitbrowser/
A phosphodiesterase 4 inhibitor with antidepressant properties.
sjwang
2019-05-22T13:50:17Z
CHEBI:104872
experimental_condition_ontology
XCO:0000614
rolipram
XCO:0000614
A phosphodiesterase 4 inhibitor with antidepressant properties.
https://www.ncbi.nlm.nih.gov/mesh/68020889
This is a condition in which the main influencing factor is an injection of a coagulated blood clot to the middle cerebral artery to induce an embolic stroke in an experimental subject.
sjwang
2019-05-22T14:06:17Z
experimental_condition_ontology
XCO:0000615
embolism injection of middle cerebral artery
XCO:0000615
Verapamil is a calcium channel blocker that is a class IV anti-arrhythmia agent.
sjwang
2019-05-23T14:15:07Z
CHEBI:9948
pubchem.compound:2520
experimental_condition_ontology
XCO:0000616
verapamil
XCO:0000616
Verapamil is a calcium channel blocker that is a class IV anti-arrhythmia agent.
https://www.ncbi.nlm.nih.gov/mesh?Db=mesh&Cmd=DetailsSearch&Term=%22Verapamil%22%5BMeSH+Terms%5D
This is any condition in which the main influencing factor is quinidine, a stereoisomer of quinine which dampens the excitability of cardiac and skeletal muscles by blocking voltage-gated sodium channels and potassium channels. Quinidine prolongs action potentials, blocks muscarinic and alpha-adrenergic neurotransmission, and inhibits multiple enzymes.
sjwang
2019-05-23T14:24:09Z
CHEBI:28593
CID:441074
MESH:68011802
(9S)-6'-methoxycinchonan-9-ol
alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol
experimental_condition_ontology
XCO:0000617
quinidine
XCO:0000617
This is any condition in which the main influencing factor is quinidine, a stereoisomer of quinine which dampens the excitability of cardiac and skeletal muscles by blocking voltage-gated sodium channels and potassium channels. Quinidine prolongs action potentials, blocks muscarinic and alpha-adrenergic neurotransmission, and inhibits multiple enzymes.
MESH:68011802
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
sjwang
2019-05-23T14:37:49Z
Sodium Channel Blockers
experimental_condition_ontology
XCO:0000618
sodium channel inhibitor
XCO:0000618
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
drugbank.category:DBCAT000600
A cardenolide glycoside that is digitoxin β-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.
sjwang
2019-05-23T14:45:00Z
CHEBI:4551
pubchem.compound:2724385
experimental_condition_ontology
XCO:0000619
digoxin
XCO:0000619
Vinblastine is a natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
sjwang
2019-05-23T15:08:50Z
CHEBI:1322
pubchem.compound:13342
experimental_condition_ontology
XCO:0000620
vinblastine
XCO:0000620
Vinblastine is a natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
https://ncit-stage.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C930&ns=ncit
Verapamil hydrochloride, tritiated on the N-methyl group. Verapamil acts as a calcium channel blocker
sjwang
2019-05-23T15:20:09Z
[Nmethyl- 3H]verapamil hydrochloride
experimental_condition_ontology
XCO:0000621
tritiated verapamil
XCO:0000621
sjwang
2019-05-23T15:28:31Z
p-3H]quinidine
experimental_condition_ontology
XCO:0000622
tritiated quinidine
XCO:0000622
sjwang
2019-05-23T15:34:38Z
Digoxin, [3H(G)]-
experimental_condition_ontology
XCO:0000623
tritiated digoxin
XCO:0000623
A short-acting barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, and is still used in veterinary medicine for induction in surgical anaesthesia.
sjwang
2019-07-17T10:08:35Z
experimental_condition_ontology
Brevinarcon
Inactin
XCO:0000624
thiobutabarbital
XCO:0000624
A short-acting barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant and hypnotic effects, and is still used in veterinary medicine for induction in surgical anaesthesia.
https://en.wikipedia.org/wiki/Thiobutabarbital
Antineoplastic agent that is also used as a veterinary anesthetic.
sjwang
2019-07-17T10:12:04Z
CHEBI:17967
MESH:D014520
experimental_condition_ontology
XCO:0000625
urethane
XCO:0000625
Surgical removal of a maxillary molar crown at the gingival line.
sjwang
2019-07-17T10:22:31Z
experimental_condition_ontology
XCO:0000626
removal of maxillary molar crown
XCO:0000626
Any condition in which the main influencing factor isspironolactone, a potassium-sparing diuretic that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone is indicated to treat a number of conditions including heart failure, edema, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome.
sjwang
2019-07-24T14:33:14Z
CHEBI:9241
DB00421
experimental_condition_ontology
XCO:0000627
spironolactone
XCO:0000627
Any condition in which the main influencing factor isspironolactone, a potassium-sparing diuretic that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone is indicated to treat a number of conditions including heart failure, edema, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome.
drugbank:DB00421
Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels.
sjwang
2019-07-24T15:29:21Z
CHEBI:39548
(3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-4-phenyl-2-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
Lipitor
experimental_condition_ontology
XCO:0000628
atorvastatin
XCO:0000628
Atorvastatin (Lipitor) is a member of the drug class known as statins. It is used for lowering cholesterol. Atorvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels increases hepatic uptake of cholesterol and reduces plasma cholesterol levels.
https://en.wikipedia.org/wiki/Atorvastatin
An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity.
sjwang
2019-07-24T16:11:51Z
MESH:D002229
pubchem.compound:636403
experimental_condition_ontology
XCO:0000629
carbenoxolone
XCO:0000629
Agents that bind to cholinoceptors (muscarinic or nicotinic) and prevent the effects of acetylcholine (ACh) and other cholinergic agonists.
sjwang
2019-07-30T14:47:58Z
experimental_condition_ontology
XCO:0000630
cholinergic antagonist
XCO:0000630
A naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters.
sjwang
2019-07-30T14:53:02Z
CHEBI:16684
experimental_condition_ontology
XCO:0000631
atropine
XCO:0000631
A naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters.
drugbank:DB00572
A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes. It belongs to the biological class EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor .
sjwang
2019-07-30T14:58:42Z
CHEBI:71272
MESH:C502994
3-hydroxyadamantylglycine-4,5-methanoprolinenitrile hydrate
BMS 477118
Onglyza
experimental_condition_ontology
XCO:0000632
saxagliptin
XCO:0000632
A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes. It belongs to the biological class EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor .
CHEBI:71272
Cortisol is a steroid hormone, in the glucocorticoid class of hormones. When used as a medication, it is known as hydrocortisone. It is produced in many animals mainly by the zona fasciculata of the adrenal cortex within the adrenal gland.
sjwang
2019-07-30T16:03:10Z
experimental_condition_ontology
cortisol
XCO:0000633
hydrocortisone
XCO:0000633
Cortisol is a steroid hormone, in the glucocorticoid class of hormones. When used as a medication, it is known as hydrocortisone. It is produced in many animals mainly by the zona fasciculata of the adrenal cortex within the adrenal gland.
https://en.wikipedia.org/wiki/Cortisol
This is a condition in which the main influencing factor is an antidiuretic, a substance that helps to control fluid balance in an animal's body by reducing urination, opposing diuresis. Its effects are opposite that of a diuretic.
sjwang
2019-07-30T16:16:56Z
experimental_condition_ontology
XCO:0000634
antidiuretic
XCO:0000634
A naturally occurring sugar polymer that acts as an energy storage molecule in plants. It is an inulin analogue and highly soluble in water .
sjwang
2019-07-30T16:18:43Z
Inutest
Polyfructosan-S
Sinistrin
experimental_condition_ontology
XCO:0000635
polyfructosan
XCO:0000635
A naturally occurring sugar polymer that acts as an energy storage molecule in plants. It is an inulin analogue and highly soluble in water .
https://en.wikipedia.org/wiki/Sinistrin
This is any condition in which the main influencing factor is an agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
sjwang
2019-08-01T12:47:37Z
CHEBI:35705
experimental_condition_ontology
XCO:0000636
immunosuppressive agent
XCO:0000636
This is any condition in which the main influencing factor is an agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
CHEBI:35705
A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
sjwang
2019-08-01T12:50:36Z
CHEBI:4031
experimental_condition_ontology
cyclosporine
XCO:0000637
cyclosporine A
XCO:0000637
A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
CHEBI:4031
A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist.
sjwang
2019-08-01T12:59:35Z
CHEBI:70773
experimental_condition_ontology
XCO:0000638
Capsazepine
XCO:0000638
A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist.
CHEBI:70773
Peptides developed according to the calcineurin A-interacting site on the C-terminus of Trpv1 was were synthesized as 1 polypeptide with transactivator of transcription (TAT)47‐57 carrier in the following order: N‐terminus–TAT47‐57–spacer (Gly‐Gly)–cargo–C terminus.
sjwang
2019-08-01T14:16:00Z
experimental_condition_ontology
XCO:0000639
V1-Cal
XCO:0000639
Peptides developed according to the calcineurin A-interacting site on the C-terminus of Trpv1 was were synthesized as 1 polypeptide with transactivator of transcription (TAT)47‐57 carrier in the following order: N‐terminus–TAT47‐57–spacer (Gly‐Gly)–cargo–C terminus.
PMID:27671317
Any experimental condition in which the internal or external environment of the myocardial system is altered.
sjwang
2019-08-01T14:40:57Z
experimental_condition_ontology
XCO:0000640
controlled in situ myocardial condition
XCO:0000640
Any experimental condition in which the internal or external environment of the myocardial system is altered.
ISBN-13:9780781733908
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is myocardial reperfusion, any situation in which the flow of blood to the heart is restored after a period of blood vessel occlusion occurring experimentally.
sjwang
2019-08-01T14:50:02Z
PMID:26448786
PMID:27671317
myocardial ischemia-reperfusion
myocardial ischemia/reperfusion
myocardium ischemia-reperfusion
myocardium ischemia/reperfusion
experimental_condition_ontology
XCO:0000641
myocardial reperfusion
XCO:0000641
This is any condition in which the main influencing factor is myocardial reperfusion, any situation in which the flow of blood to the heart is restored after a period of blood vessel occlusion occurring experimentally.
ISBN-13:978-1455756438
https://www.merriam-webster.com/
Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
sjwang
2019-08-01T17:00:38Z
CHEBI:6980
CID:9415
MESH:D016686
MCT
crotaline
experimental_condition_ontology
XCO:0000642
monocrotaline
XCO:0000642
Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
https://www.ncbi.nlm.nih.gov/mesh/68016686
sjwang
2019-10-03T15:41:29Z
experimental_condition_ontology
XCO:0000643
controlled exposure to a foster mother of a different strain within the same species.
XCO:0000643
A monoclonal antibody that appears to be specific for a constant determinant of the rat alpha/beta heterodimeric T cell receptor.
sjwang
2019-11-05T10:21:40Z
R73
experimental_condition_ontology
XCO:0000644
anti-T cell receptor antibody
XCO:0000644
This is any condition in which the main influencing factor is propofol, an intravenous anesthetic agent which has a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. Propofol has also been used as an anticonvulsant and antiemetic.
sjwang
2019-11-27T12:37:25Z
CHEBI:44915
CID:4943
2,6-DIISOPROPYLPHENOL
2,6-bis(propan-2-yl)phenol
experimental_condition_ontology
XCO:0000645
propofol
XCO:0000645
This is any condition in which the main influencing factor is propofol, an intravenous anesthetic agent which has a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. Propofol has also been used as an anticonvulsant and antiemetic.
MESH:D015742
Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention.
sjwang
2019-12-04T15:04:39Z
CAS:25843-45-2
pubchem.compound:329770827
ML-MFCD00126912
experimental_condition_ontology
XCO:0000646
Azoxymethane
XCO:0000646
A selective endothelin ETA receptor antagonist. It is being evaluated as a treatment for congestive heart failure and hypertension.
slaulede
2019-12-09T18:27:43Z
experimental_condition_ontology
XCO:0000647
darusentan
XCO:0000647
A selective endothelin ETA receptor antagonist. It is being evaluated as a treatment for congestive heart failure and hypertension.
drugbank:DB04883
An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
slaulede
2019-12-10T17:07:59Z
(dichloromethanediyl)bis(phosphonic acid)
clodronate
experimental_condition_ontology
XCO:0000648
clodronic acid
XCO:0000648
An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
CHEBI:110423
This is any condition in which the main influencing factor is trans-4-hydroxy-L-proline, an optically active form of 4-hydroxyproline having L-trans-configuration. Trans-4-hydroxy-L-proline is a human, mouse, and plant metabolite that is also used to cause disease in a rat model of urolithiasis.
sjwang
2019-12-12T13:16:31Z
CHEBI:18095
experimental_condition_ontology
XCO:0000649
trans-4-hydroxy-L-proline
XCO:0000649
This is any condition in which the main influencing factor is trans-4-hydroxy-L-proline, an optically active form of 4-hydroxyproline having L-trans-configuration. Trans-4-hydroxy-L-proline is a human, mouse, and plant metabolite that is also used to cause disease in a rat model of urolithiasis.
CHEBI:18095
PMID:37334022
A drink made up of water and a specified amount of cilazapril consumed by an organism as part of an experiment. Cilazapril is a prodrug that is hydrolyzed to its main metabolite cilazaprilat, an inhibitor of angiotensin-converting enzyme (ACE).
slaulede
2019-12-16T15:56:17Z
experimental_condition_ontology
XCO:0000650
controlled cilazapril content drinking water
XCO:0000650
A condition in which the main influencing factor is E4177, an agent that blocks one or more angiotensin II receptors.
slaulede
2019-12-16T16:34:05Z
4'-((2-cyclopropyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid
E-4177
experimental_condition_ontology
XCO:0000651
E4177
XCO:0000651
A drink made up of water and a specified amount of E4177 consumed by an organism as part of an experiment. E4177 is an agent that blocks one or more angiotensin II receptors.
slaulede
2019-12-16T16:39:42Z
controlled 4'-((2-cyclopropyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid content drinking water
controlled E-4177 content drinking water
experimental_condition_ontology
XCO:0000652
controlled E4177 content drinking water
XCO:0000652
Any condition in which the main influencing factor is an agent that blocks the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
slaulede
2019-12-16T17:38:36Z
experimental_condition_ontology
XCO:0000653
ionotropic glutamate receptor antagonist
XCO:0000653
Kynurenate is a product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Kynurenate is an endogenous antagonist of the ionotropic glutamate receptors.
slaulede
2019-12-16T17:41:34Z
experimental_condition_ontology
XCO:0000654
kynurenate
XCO:0000654
An abnormal form of prion protein that in mammals includes pathogenic forms which arise sporadically, as a result of genetic mutation, or by transmission (as by ingestion of infected tissue) and which upon accumulation in the brain cause a prion disease (such as bovine spongiform encephalopathy or Creutzfeldt-Jakob disease.
slaulede
2019-12-19T11:45:30Z
proteinacious infectious particle
experimental_condition_ontology
XCO:0000655
prion
XCO:0000655
An abnormal form of prion protein that in mammals includes pathogenic forms which arise sporadically, as a result of genetic mutation, or by transmission (as by ingestion of infected tissue) and which upon accumulation in the brain cause a prion disease (such as bovine spongiform encephalopathy or Creutzfeldt-Jakob disease.
https://www.merriam-webster.com/dictionary/prion
An oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections
sjwang
2020-01-28T10:22:22Z
experimental_condition_ontology
XCO:0000656
ganciclovir
XCO:0000656
A substance that kills or slows the growth of a virus.
sjwang
2020-01-28T10:24:15Z
experimental_condition_ontology
XCO:0000657
antiviral agent
XCO:0000657
A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.
slaulede
2020-01-28T16:25:54Z
MESH:D015737
rac-methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
experimental_condition_ontology
XCO:0000658
nisoldipine
XCO:0000658
A racemate consisting of equimolar amounts of (R)- and (S)-nisoldipine. A calcium channel blocker, it is used in the treatment of hypertension and angina pectoris.
CHEBI:7577
A regimen of solid food in which the amount of nisoldipine consumed is maintained at a specified level.
slaulede
2020-01-28T16:42:16Z
experimental_condition_ontology
XCO:0000659
controlled nisoldipine content diet
XCO:0000659
A drink made up of water and a specified amount of nisoldipine in which the amount of nisoldipine consumed is maintained at a specified level.
slaulede
2020-01-28T16:53:19Z
experimental_condition_ontology
XCO:0000660
controlled nisoldipine content drinking water
XCO:0000660
A surgical manipulation causing blood vessel blockage by the clipping of one renal artery and surgical removal of the contralateral kidney.
slaulede
2020-01-31T09:44:27Z
1k1c
experimental_condition_ontology
XCO:0000661
one-kidney, one-clip occlusion
XCO:0000661
A surgical manipulation causing blood vessel blockage by the clipping of one renal artery and surgical removal of the contralateral kidney.
https://www.hindawi.com/journals/bmri/2015/528757/tab1/
A surgical manipulation causing blood vessel blockage by the clipping of one renal artery.
slaulede
2020-01-31T09:55:35Z
2K1C
experimental_condition_ontology
XCO:0000662
two-kidney, one-clip occlusion
XCO:0000662
A surgical manipulation causing blood vessel blockage by the clipping of one renal artery.
https://www.hindawi.com/journals/bmri/2015/528757/tab1/
A surgical manipulation causing blood vessel blockage by the dissection and clipping of both renal arteries.
slaulede
2020-01-31T10:08:45Z
2K2C
experimental_condition_ontology
XCO:0000663
two-kidney, two-clip occlusion
XCO:0000663
A surgical manipulation causing blood vessel blockage by the dissection and clipping of both renal arteries.
https://www.hindawi.com/journals/bmri/2015/528757/tab1/
An agent that selectively binds to and activates adrenergic receptors.
slaulede
2020-02-11T14:23:32Z
adrenergic agonists
adrenoceptor agonists
adrenomimetic
adrenomimetics
experimental_condition_ontology
XCO:0000664
adrenergic receptor agonist
XCO:0000664
An agent that selectively binds to and activates adrenergic receptors.
CHEBI:37886
A substance that selectively binds to and activates beta-adrenergic receptors.
slaulede
2020-02-11T14:28:45Z
CHEBI:35522
beta-adrenergic agonists
beta-adrenergic receptor agonist
beta-adrenergic receptor agonists
beta-adrenoceptor agonists
experimental_condition_ontology
XCO:0000665
beta-adrenergic agonist
XCO:0000665
A substance that selectively binds to and activates beta-adrenergic receptors.
CHEBI:35522
Any condition in which the main influencing factor is a substance that causes an increase in the expansion of a bronchus or bronchial tubes.
slaulede
2020-02-11T14:48:25Z
bronchodilator
bronchodilator agents
broncholytic agent
experimental_condition_ontology
XCO:0000666
bronchodilator agent
XCO:0000666
A beta-adrenergic receptor agonist that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.
slaulede
2020-02-11T14:51:50Z
CHEBI:174690
MESH:D002976
1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol
experimental_condition_ontology
XCO:0000667
clenbuterol
XCO:0000667
A beta-adrenergic receptor agonist that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.
CHEBI:174690
The insertion of a tubular, flexible surgical instrument into an artery to withdraw a substantial, yet controlled, amount of blood.
slaulede
2020-02-11T16:01:15Z
arterial catheter implantation and bleeding
arterial catheter implantation and hemorrhaging
experimental_condition_ontology
XCO:0000668
arterial catheter implantation and controlled hemorrhage
XCO:0000668
Any condition in which the main influencing factor is diazoxide, a benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
slaulede
2020-03-05T14:07:13Z
CHEBI:4495
Proglycem
experimental_condition_ontology
XCO:0000669
diazoxide
XCO:0000669
Any condition in which the main influencing factor is diazoxide, a benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
CHEBI:4495
A technique in which the amount of food provided to a control group of animals is matched to that consumed by the experimental group, so as to determine the extent to which the effect of a treatment on body weight or body composition occurred independently of changes of energy intake.
slaulede
2020-03-05T14:46:27Z
experimental_condition_ontology
XCO:0000670
Pair-fed diet
XCO:0000670
A technique in which the amount of food provided to a control group of animals is matched to that consumed by the experimental group, so as to determine the extent to which the effect of a treatment on body weight or body composition occurred independently of changes of energy intake.
PMID:20620991
A tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.
slaulede
2020-03-05T15:49:21Z
CHEBI:50845
Doryx
Doxyhexal
Doxylin
experimental_condition_ontology
XCO:0000671
doxycycline
XCO:0000671
A tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.
CHEBI:50845
This is any condition in which the main influencing factor is a subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
slaulede
2020-03-05T16:13:01Z
CHEBI:26895
MESH:D013754
experimental_condition_ontology
XCO:0000672
tetracyclines
XCO:0000672
This is any condition in which the main influencing factor is a subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
CHEBI:26895
This is any condition in which the main influencing factor is an alpha-adrenergic agonist, an agent that selectively binds to and activates alpha-adrenergic receptors.
slaulede
2020-03-05T16:49:13Z
CHEBI:35569
alpha-adrenergic agonists
alpha-adrenergic receptor agonist
alpha-adrenoceptor agonists
experimental_condition_ontology
XCO:0000673
alpha-adrenergic agonist
XCO:0000673
This is any condition in which the main influencing factor is an alpha-adrenergic agonist, an agent that selectively binds to and activates alpha-adrenergic receptors.
CHEBI:35569
This is any condition in which the main influencing factor is clonidine, an imidazoline sympatholytic agent that stimulates alpha-2 adrenergic receptors and central imidazoline receptors. It is commonly used in the management of hypertension.
slaulede
2020-03-05T16:56:21Z
CHEBI:46631
MESH:D003000
Catapres
Kapvay
Nexiclon
experimental_condition_ontology
XCO:0000674
clonidine
XCO:0000674
This is any condition in which the main influencing factor is clonidine, an imidazoline sympatholytic agent that stimulates alpha-2 adrenergic receptors and central imidazoline receptors. It is commonly used in the management of hypertension.
MESH:D003000
A condition in which gene transfer has been performed using a retrovirus as the carrier of the genetic material. A retrovirus is any of a family (Retroviridae) of single-stranded RNA viruses that produce reverse transcriptase by means of which DNA is produced using their RNA as a template and incorporated into the genome of infected cells.
slaulede
2020-03-06T11:39:41Z
retroviral gene transfer
retrovirus transfer
experimental_condition_ontology
XCO:0000675
gene transfer using retrovirus vector
XCO:0000675
A condition in which gene transfer has been performed using a retrovirus as the carrier of the genetic material. A retrovirus is any of a family (Retroviridae) of single-stranded RNA viruses that produce reverse transcriptase by means of which DNA is produced using their RNA as a template and incorporated into the genome of infected cells.
https://www.merriam-webster.com/dictionary/retrovirus
A condition in which the rat erb-b2 receptor tyrosine kinase 2 gene (Erbb2) gene has been (transiently or stably) transferred into a cell or organism using a retrovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
slaulede
2020-03-06T12:01:39Z
retroviral transfer of the rat Erbb2 gene
transfer of recombinant retrovirus containing the rat Erbb2 gene
experimental_condition_ontology
pJR-neu
XCO:0000676
gene transfer of the rat erb-b2 receptor tyrosine kinase 2 gene using a retrovirus vector
XCO:0000676
A condition in which the rat erb-b2 receptor tyrosine kinase 2 gene (Erbb2) gene has been (transiently or stably) transferred into a cell or organism using a retrovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
PMID:1913683
A drink made up of water and a specified amount of enalapril consumed by an organism as part of an experiment. Enalapril, a prodrug that is rapidly metabolized in the liver to enalaprilat, is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
slaulede
2020-03-06T13:46:09Z
controlled Enacard content drinking water
controlled Renitec content drinking water
controlled Vasotec content drinking water
experimental_condition_ontology
XCO:0000677
controlled enalapril content drinking water
XCO:0000677
A drink made up of water and a specified amount of enalapril consumed by an organism as part of an experiment. Enalapril, a prodrug that is rapidly metabolized in the liver to enalaprilat, is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE).
American_Heritage:The_American_Heritage_Dictionary_of_the_English_Language--4th_Ed
https://en.wikipedia.org/wiki/Enalapril
A condition in which the rat MER proto-oncogene, tyrosine kinase gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
slaulede
2020-03-13T14:57:43Z
PMID:11592982
RGD:69283
adenoviral transfer of the rat Mertk gene
transfer of recombinant adenovirus containing the rat Mertk gene
experimental_condition_ontology
Ad-Mertk
XCO:0000678
gene transfer of the rat MER proto-oncogene, tyrosine kinase gene using an adenovirus vector
XCO:0000678
A condition in which the rat MER proto-oncogene, tyrosine kinase gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
PMID:11592982
Webster:Random_House_Kernerman_Websters_College_Dictionary_2010
A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring. Used as a lipid -lowering drug.
slaulede
2020-04-20T13:16:09Z
CHEBI:5001
MESH:D011345
experimental_condition_ontology
XCO:0000679
fenofibrate
XCO:0000679
A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring. Used as a lipid -lowering drug.
CHEBI:5001
This is any condition in which the main influencing factor is a substance used to treat hyperlipidemia (an excess of lipids in the blood).
slaulede
2020-04-20T13:26:24Z
CHEBI:35679
antilipemic drug
experimental_condition_ontology
XCO:0000680
antilipemic agent
XCO:0000680
This is any condition in which the main influencing factor is a substance used to treat hyperlipidemia (an excess of lipids in the blood).
CHEBI:35679
This is any condition in which the main influencing factor is Medica 16, an α,ω-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties.
slaulede
2020-04-24T12:47:27Z
CAS:87272-20-6
CHEBI:149582
3,3,14,14-Tetramethylhexadecanedioic acid
Medic-16
experimental_condition_ontology
XCO:0000681
Medica 16
XCO:0000681
This is any condition in which the main influencing factor is Medica 16, an α,ω-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties.
CHEBI:149582
A benzoate ester that has formula C19H20F3NO2. Functionally, it is an anorectic and hypolipidemic agent.
slaulede
2020-04-27T18:51:37Z
Mediator
benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester
experimental_condition_ontology
XCO:0000682
Benfluorex
XCO:0000682
A benzoate ester that has formula C19H20F3NO2. Functionally, it is an anorectic and hypolipidemic agent.
CHEBI:93826
https://en.wikipedia.org/wiki/Benfluorex
A bile acid-binding anticholesteremic drug that helps decrease the risk for strokes and heart attacks.
slaulede
2020-04-30T12:29:58Z
Cholestyramine resin
Prevalite
Questran
experimental_condition_ontology
XCO:0000683
cholestyramine
XCO:0000683
A bile acid-binding anticholesteremic drug that helps decrease the risk for strokes and heart attacks.
https://www.webmd.com/drugs/2/drug-49/questran-light-oral/details
A condition in which the main influencing factor is nateglinide, an N-acyl-D-phenylalanine resulting from the formal condensation of the amino group of D-phenylalanine with the carboxy group of trans-4-isopropylcyclohexanecarboxylic acid. An orally-administered, rapidly-absorbed, short-acting insulinotropic agent, it is used for the treatment of type 2 diabetes mellitus.
slaulede
2020-04-30T14:19:39Z
CHEBI:31897
N-[(trans-4-isopropylcyclohexyl)carbonyl]-D-phenylalanine
experimental_condition_ontology
XCO:0000684
nateglinide
XCO:0000684
A condition in which the main influencing factor is nateglinide, an N-acyl-D-phenylalanine resulting from the formal condensation of the amino group of D-phenylalanine with the carboxy group of trans-4-isopropylcyclohexanecarboxylic acid. An orally-administered, rapidly-absorbed, short-acting insulinotropic agent, it is used for the treatment of type 2 diabetes mellitus.
CHEBI:31897
A liquid composed of two immiscible substances, typically some form of fat and water. In parenteral nutrition, a fat emulsion may contain phospholipids, triglycerides and essential fatty acids.
slaulede
2020-04-30T14:52:23Z
lipid emulsion
experimental_condition_ontology
XCO:0000685
fat emulsion
XCO:0000685
A liquid composed of two immiscible substances, typically some form of fat and water. In parenteral nutrition, a fat emulsion may contain phospholipids, triglycerides and essential fatty acids.
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/fat-emulsion
A sterile, non‑pyrogenic fat emulsion intended as a source of calories and essential fatty acids for use in a pharmacy admixture program. It is made up of 20% Soybean Oil, 1.2% Egg Yolk, Phospholipids, 2.25% Glycerin, and Water for Injection. In addition, sodium hydroxide has been added to adjust the pH so that the final product pH is 6 to 8.9.
slaulede
2020-04-30T15:09:24Z
PMID:12419950
Intralipid
Intralipid 20%
Intralipos
emulsion 68890-65-3
experimental_condition_ontology
XCO:0000686
Intralipid 20
XCO:0000686
A sterile, non‑pyrogenic fat emulsion intended as a source of calories and essential fatty acids for use in a pharmacy admixture program. It is made up of 20% Soybean Oil, 1.2% Egg Yolk, Phospholipids, 2.25% Glycerin, and Water for Injection. In addition, sodium hydroxide has been added to adjust the pH so that the final product pH is 6 to 8.9.
https://www.fresenius-kabi.com/en-ca/products/lipid-emulsions
An experimental drug candidate for the treatment of HIV infection and in combination with Tropifexor for non-alcoholic steatohepatitis. It is an inhibitor of CCR2 and CCR5 receptors.
slaulede
2020-05-01T16:51:23Z
MESH:C506967
CVC
TAK 652
TBR 652
TBR-652
TBR652
experimental_condition_ontology
XCO:0000687
cenicriviroc
XCO:0000687
An experimental drug candidate for the treatment of HIV infection and in combination with Tropifexor for non-alcoholic steatohepatitis. It is an inhibitor of CCR2 and CCR5 receptors.
https://en.wikipedia.org/wiki/Cenicriviroc
Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon. Myelin basic protein may constitute as much as one-third of all protein in myelin.
slaulede
2020-05-11T16:03:19Z
RGD:736262
Golli-MBP
MBP
MBP S
Mbps
myelin A1 protein
myelin basic protein S
myelin membrane encephalitogenic protein
experimental_condition_ontology
XCO:0000688
myelin basic protein
XCO:0000688
Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon. Myelin basic protein may constitute as much as one-third of all protein in myelin.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/myelin-basic-protein
Vitamin C is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. Humans, unlike most animals, are unable to synthesize vitamin C endogenously, so it is an essential dietary component.
slaulede
2020-05-11T17:25:22Z
CHEBI:21241
MESH:D001205
L-ascorbic acid
Sodium Ascorbate
experimental_condition_ontology
XCO:0000689
vitamin C
XCO:0000689
Vitamin C is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. Humans, unlike most animals, are unable to synthesize vitamin C endogenously, so it is an essential dietary component.
https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/
A solid diet in which the amount of any vitamin is maintained at a specified level. Vitamins are organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
slaulede
2020-05-11T17:39:15Z
CHEBI:33229
MESH:D014815
experimental_condition_ontology
XCO:0000690
controlled vitamin content diet
XCO:0000690
A solid diet in which the amount of any vitamin is maintained at a specified level. Vitamins are organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
MESH:D014815
A solid diet in which the amount of vitamin C is maintained at a specified level. Vitamin C is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement.
slaulede
2020-05-11T17:49:21Z
controlled ascorbate content diet
controlled ascorbic acid content diet
experimental_condition_ontology
XCO:0000691
controlled vitamin C content diet
XCO:0000691
A solid diet in which the amount of vitamin C is maintained at a specified level. Vitamin C is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement.
https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/
An ammonium salt that has formula C6H15N2O2. It is a slowly hydrolyzed cholinergic agonist that acts at both muscarinic receptors and nicotinic receptors.
slaulede
2020-05-12T16:35:15Z
CHEBI:3385
MESH:D002217
Isopto Carbachol
Miostat
carbamylcholine
carbastat
carboptic
experimental_condition_ontology
XCO:0000692
carbachol
XCO:0000692
An agent that selectively binds to and activates cholinergic receptors.
slaulede
2020-05-12T16:44:51Z
CHEBI:38324
MESH:D018679
acetylcholine receptor agonist
cholinomimetic
experimental_condition_ontology
XCO:0000693
cholinergic agonist
XCO:0000693
An agent that selectively binds to and activates cholinergic receptors.
CHEBI:38324
Any substance that combines with an enzyme to increase its catalytic activity. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism
slaulede
2020-05-15T09:27:57Z
experimental_condition_ontology
XCO:0000694
enzyme activator
XCO:0000694
Any substance that combines with an enzyme to increase its catalytic activity. These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism
Miller-Keane:Miller-Keane_Encyclopedia_and_Dictionary_of_Medicine_Nursing_and_Allied_Health--7th_Ed
https://en.wikipedia.org/wiki/Enzyme_activator
An effector that binds to and activates soluble guanylate cyclase (EC 4.6.1.2). It increases the activity of the enzyme only when the heme iron is oxidized (Fe3+) or the heme group is missing.
slaulede
2020-05-15T09:38:35Z
CHEBI:76022
sGC activator
experimental_condition_ontology
XCO:0000695
soluble guanylate cyclase activator
XCO:0000695
An effector that binds to and activates soluble guanylate cyclase (EC 4.6.1.2). It increases the activity of the enzyme only when the heme iron is oxidized (Fe3+) or the heme group is missing.
CHEBI:76022
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/enzyme-activator
An allosteric enzyme activator that increases guanylate cyclase activity only when the heme iron is in its reduced state (Fe2+).
slaulede
2020-05-15T09:53:41Z
CHEBI:76022
sGC stimulator
experimental_condition_ontology
XCO:0000696
soluble guanylate cyclase stimulator
XCO:0000696
An allosteric enzyme activator that increases guanylate cyclase activity only when the heme iron is in its reduced state (Fe2+).
CHEBI:76022
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/enzyme-activator
This chemical belongs to a novel group of small molecule compounds which increase the enzymatic activity of soluble guanylate cyclase.
slaulede
2020-05-15T10:01:48Z
PMID:22783192
1-(6-{2-[({3-methyl-4 -[(trifluoromethyl)oxy]-4-biphenylyl}methyl)oxy] phenyl}-2-pyridinyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
experimental_condition_ontology
XCO:0000697
GSK2181236A
XCO:0000697
This chemical belongs to a novel group of small molecule compounds which increase the enzymatic activity of soluble guanylate cyclase.
PMID:22783192
This chemical belongs to a novel group of small molecule compounds which increase the enzymatic activity of soluble guanylate cyclase.
slaulede
2020-05-15T10:36:38Z
PMID:22783192
Nelociguat
experimental_condition_ontology
XCO:0000698
BAY60-4552
XCO:0000698
This chemical belongs to a novel group of small molecule compounds which increase the enzymatic activity of soluble guanylate cyclase.
PMID:22783192
A regimen of solid food in which the amount of GSK2181236A consumed is controlled.
slaulede
2020-05-15T11:12:27Z
PMID:22783192
controlled 1-(6-{2-[({3-methyl-4 -[(trifluoromethyl)oxy]-4-biphenylyl}methyl)oxy] phenyl}-2-pyridinyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid content diet
experimental_condition_ontology
XCO:0000699
controlled GSK2181236A content diet
XCO:0000699
A regimen of solid food in which the amount of GSK2181236A consumed is controlled.
PMID:22783192
A regimen of solid food in which the amount of BAY60-4552 consumed is controlled.
slaulede
2020-05-15T11:16:58Z
PMID:22783192
Nelociguat
experimental_condition_ontology
XCO:0000700
controlled BAY60-4552 content diet
XCO:0000700
A regimen of solid food in which the amount of BAY60-4552 consumed is controlled.
PMID:22783192
An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom.
slaulede
2020-05-21T14:51:33Z
MESH:D013844
MESH:D013844
experimental_condition_ontology
XCO:0000702
thiazoles
XCO:0000702
An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom.
CHEBI:48901
A constituent of fox urine and feces that may be an innately aversive odor to rodents.
slaulede
2020-05-21T15:14:18Z
MESH:C451263
2,4,5-Trimethyl-4,5-dihydro-1,3-thiazole
TMT
fox odor
experimental_condition_ontology
XCO:0000703
2,4,5 trimethylthiazoline
XCO:0000703
A constituent of fox urine and feces that may be an innately aversive odor to rodents.
https://en.wikipedia.org/wiki/Trimethylthiazoline
A surgical manipulation causing blockage of one or both of the common carotid arteries, or of a branch (internal or external) of the common carotid arteries.
slaulede
2020-05-21T15:46:29Z
UCAO
common carotid artery occlusion
permanent carotid artery occlusion
unilateral carotid artery occlusion
experimental_condition_ontology
XCO:0000704
carotid artery occlusion
XCO:0000704
A surgical manipulation causing blockage of one or both of the common carotid arteries, or of a branch (internal or external) of the common carotid arteries.
Mosby:Mosbys_Medical_Dictionary--8th_Ed
Neutral organic radicals are subvalent molecules, i.e., they have unpaired electrons, and, as such, they are typically highly reactive, transient species with short lifetimes that tend to dimerize, disproportionate, or react with oxygen.
slaulede
2020-05-22T12:37:56Z
experimental_condition_ontology
XCO:0000705
organic radical
XCO:0000705
Neutral organic radicals are subvalent molecules, i.e., they have unpaired electrons, and, as such, they are typically highly reactive, transient species with short lifetimes that tend to dimerize, disproportionate, or react with oxygen.
https://www.sciencedirect.com/topics/chemistry/organic-radical
Physicochemically lithium phthalocyanine is very stable; its response to pO2 does not change with conditions and environments (e.g., pH, temperature, redox conditions) likely to occur in viable biological systems. It is an organic radical compound that forms metallic-organic, paramagnetic crystallites that appear very useful for in vitro and in vivo electron paramagnetic resonance oximetry.
slaulede
2020-05-22T12:53:58Z
LiPc
experimental_condition_ontology
XCO:0000706
lithium phthalocyanine
XCO:0000706
Physicochemically lithium phthalocyanine is very stable; its response to pO2 does not change with conditions and environments (e.g., pH, temperature, redox conditions) likely to occur in viable biological systems. It is an organic radical compound that forms metallic-organic, paramagnetic crystallites that appear very useful for in vitro and in vivo electron paramagnetic resonance oximetry.
PMID:8390665
Carvedilol is a beta-blocker that works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. It is used to treat heart failure, high blood pressure, and heart attack patients.
slaulede
2020-05-28T16:40:29Z
CHEBI:3441
MESH:D000077261
1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
Coreg
Coropres
Dilatrend
Eucardic
Kredex
Querto
experimental_condition_ontology
XCO:0000707
carvedilol
XCO:0000707
Carvedilol is a beta-blocker that works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. It is used to treat heart failure, high blood pressure, and heart attack patients.
https://medlineplus.gov/druginfo/meds/a697042.html
A regimen of solid food in which the amount of carvedilol consumed is controlled.
slaulede
2020-05-28T16:52:10Z
PMID:17551266
controlled Coreg content diet
controlled Querto content diet
experimental_condition_ontology
XCO:0000708
controlled carvedilol content diet
XCO:0000708
A regimen of solid food in which the amount of carvedilol consumed is controlled.
PMID:17551266
A condition in which cells from one organism are used to cause cancer in another organism by injection of, or other means of transferring, live cells from the donor organism to the host organism. Cancer is a disease characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
slaulede
2020-06-05T10:25:14Z
tumor cells
malignant neoplasm cells
malignant tumor cells
carcinoma cells
primary cancer cells
sarcoma cells
experimental_condition_ontology
XCO:0000709
cancer cells
XCO:0000709
A condition in which cells from one organism are used to cause cancer in another organism by injection of, or other means of transferring, live cells from the donor organism to the host organism. Cancer is a disease characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.
DOID:162
A condition in which the main influencing factor is a rat colonic carcinoma cell line used to study biochemical correlates of metastasis.
slaulede
2020-06-05T10:56:45Z
ECACC:90062901
PMID:19850492
DHD K12/TRb cells
DHD-K12 TRb cells
DHD/K12 cells
TRb cells
experimental_condition_ontology
XCO:0000710
DHD/K12/TRb cells
XCO:0000710
A condition in which the main influencing factor is a rat colonic carcinoma cell line used to study biochemical correlates of metastasis.
ECACC:90062901
An antimicrobial that is also being studied as a treatment for cancer. It is derived from the endogenous amino acid taurine.
slaulede
2020-06-05T11:10:11Z
CHEBI:135173
MESH:C012566
tauroflex
taurolin
tauroline
experimental_condition_ontology
XCO:0000711
taurolidine
XCO:0000711
An antimicrobial that is also being studied as a treatment for cancer. It is derived from the endogenous amino acid taurine.
https://en.wikipedia.org/wiki/Taurolidine
Any drug which binds to vasopressin receptors and triggers a response.
slaulede
2020-06-05T13:31:12Z
CHEBI:59727
antidiuretic hormone agonist
arginine vasopressin receptor agonist
argipressin receptor agonist
experimental_condition_ontology
XCO:0000712
vasopressin receptor agonist
XCO:0000712
Any drug which binds to vasopressin receptors and triggers a response.
CHEBI:59727
A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. Its action is mediated by the vasopressin receptor V2. It has prolonged antidiuretic activity, but little pressor effects.
slaulede
2020-06-05T13:42:43Z
CHEBI:4450
MESH:D003894
1-Desamino-8-arginine Vasopressin
Adiuretin
Deamino Arginine Vasopressin
Desmogalen
dDAVP
experimental_condition_ontology
XCO:0000713
desmopressin
XCO:0000713
A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. Its action is mediated by the vasopressin receptor V2. It has prolonged antidiuretic activity, but little pressor effects.
CHEBI:4450
MESH:D003894
A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively. It is a mitogen-activated protein kinase inhibitor.
slaulede
2020-06-08T14:10:13Z
CHEBI:90681
MESH:C406525
EC 2.7.11.24 inhibitor
trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole
trans-4-[4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl]cyclohexan-1-ol
experimental_condition_ontology
XCO:0000714
SB-239063
XCO:0000714
A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively. It is a mitogen-activated protein kinase inhibitor.
CHEBI:90681
Any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of a mitogen-activated protein kinase.
slaulede
2020-06-08T14:19:35Z
EC 2.7.11.24 inhibitor
experimental_condition_ontology
MAPK inhibitor
XCO:0000715
mitogen-activated protein kinase inhibitor
XCO:0000715
Any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of a mitogen-activated protein kinase.
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
A regimen of solid food in which the amount of SB-239063 consumed is controlled.
slaulede
2020-06-08T14:38:59Z
controlled EC 2.7.11.24 inhibitor content diet
PMID:14561850
experimental_condition_ontology
XCO:0000716
controlled SB-239063 content diet
XCO:0000716
MRI contrast agents are an indispensable part of magnetic resonance imaging. Contrast agents are used to improve the visibility of internal body structures in magnetic resonance imaging (MRI).
slaulede
2020-06-08T14:55:27Z
CHEBI:37335
experimental_condition_ontology
XCO:0000717
MRI contrast agent
XCO:0000717
MRI contrast agents are an indispensable part of magnetic resonance imaging. Contrast agents are used to improve the visibility of internal body structures in magnetic resonance imaging (MRI).
https://en.wikipedia.org/wiki/MRI_contrast_agent
https://radiopaedia.org/articles/mri-contrast-agents?lang=us
Gadolinium-Based Contrast Agents (GBCA) are intravenous drugs used in diagnostic imaging procedures to enhance the quality of magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA).
slaulede
2020-06-08T15:03:11Z
GBCA
experimental_condition_ontology
XCO:0000718
gadolinium-based contrast agents
XCO:0000718
Gadolinium-Based Contrast Agents (GBCA) are intravenous drugs used in diagnostic imaging procedures to enhance the quality of magnetic resonance imaging (MRI) or magnetic resonance angiography (MRA).
https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/information-gadolinium-based-contrast-agents
A gadolinium coordination entity that has formula C28H54GdN5O20.
slaulede
2020-06-08T15:14:36Z
CHEBI:31797
Gd-DTPA
Magnevist
gadolinium (bis{2-[(carboxylatomethyl)(carboxymethyl)amino]ethyl}amino)acetate--1-deoxy-1-(methylamino)-D-glucitol (1:2)
experimental_condition_ontology
XCO:0000719
gadopentetate dimeglumine
XCO:0000719
A gadolinium coordination entity that has formula C28H54GdN5O20.
CHEBI:31797
A condition involving eye surgery using a laser to shrink or destroy abnormal structures in the retina, or to intentionally cause scarring.
slaulede
2020-06-08T17:19:58Z
laser coagulation
laser eye surgery
photocoagulation
experimental_condition_ontology
XCO:0000720
laser photocoagulation
XCO:0000720
A condition involving eye surgery using a laser to shrink or destroy abnormal structures in the retina, or to intentionally cause scarring.
https://medlineplus.gov/ency/article/007664.htm
This is any condition whose main influencing factor is eprosartan, a member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.
slaulede
2020-06-11T17:41:02Z
CHEBI:4814
Eprozar
Teveten
experimental_condition_ontology
XCO:0000721
eprosartan
XCO:0000721
This is any condition whose main influencing factor is eprosartan, a member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.
CHEBI:4814
This is any condition in which the main influencing factor is solid food deprivation, a condition in which solid food is withheld for a specified period of time, while nourishment through liquids is provided.
slaulede
2020-06-12T17:33:11Z
PMID:23955305
experimental_condition_ontology
XCO:0000722
solid food deprivation
XCO:0000722
This is any condition in which the main influencing factor is solid food deprivation, a condition in which solid food is withheld for a specified period of time, while nourishment through liquids is provided.
PMID:23955305
https://www.merriam-webster.com/
A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.
slaulede
2020-06-15T15:35:54Z
CHEBI:28885
1-butanol
1-butyl alcohol
butan-1-ol
n-butanol
experimental_condition_ontology
XCO:0000723
butanol
XCO:0000723
A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.
CHEBI:28885
A primary alcohol that is butanol in which one or several of the carbon (C12) atoms is replaced by radioactive Carbon-14.
slaulede
2020-06-15T16:30:42Z
CHEBI:28885
https://arcinova.com/services/isotope-labelling
C-14 butanol
C14 butanol
radiocarbon butanol
experimental_condition_ontology
XCO:0000724
Carbon-14 butanol
XCO:0000724
A primary alcohol that is butanol in which one or several of the carbon (C12) atoms is replaced by radioactive Carbon-14.
CHEBI:28885
https://arcinova.com/services/isotope-labelling
Hesperetin is the aglycone of hesperidin - clathration by CD enhances hesperetin solubility.
slaulede
2020-06-23T14:43:30Z
PMID:19966469
experimental_condition_ontology
XCO:0000725
cyclodextrin (CD)-clathrated hesperetin
XCO:0000725
Hesperetin is the aglycone of hesperidin - clathration by CD enhances hesperetin solubility.
PMID:19966469
A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
slaulede
2020-06-23T14:57:51Z
CHEBI:28775
MESH:D006569
PMID:19966469
Hesperetin 7-O-Rutinoside
Hesperidin 2S
experimental_condition_ontology
XCO:0000726
hesperidin
XCO:0000726
A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
CHEBI:28775
Surgical removal of part or all of the spleen, the highly vascular lymphoid organ which serves to store blood, disintegrate old blood cells, filter foreign substances from the blood, and produce lymphocytes.
slaulede
2020-06-25T12:48:31Z
spleen removal
experimental_condition_ontology
XCO:0000727
splenectomy
XCO:0000727
Surgical removal of part or all of the spleen, the highly vascular lymphoid organ which serves to store blood, disintegrate old blood cells, filter foreign substances from the blood, and produce lymphocytes.
American_Heritage:The_American_Heritage_Medical_Dictionary_2007
Dorland:Dorlands_Illustrated_Medical_Dictionary--31st_Ed
Surgical removal of a portion of the spleen, resulting in reduction but not elimination of the physiological functions of the spleen.
slaulede
2020-06-25T12:58:14Z
PS
experimental_condition_ontology
XCO:0000728
partial splenectomy
XCO:0000728
Surgical removal of a portion of the spleen, resulting in reduction but not elimination of the physiological functions of the spleen.
Gale:Gale_Encyclopedia_of_Medicine
Enrasentan is an orally active mixed endothelin A/B receptor antagonist with a 100-fold greater affinity for the endothelin A receptor.
slaulede
2020-07-27T15:38:14Z
(1S,2R,3S)-3-(2-(2-HYDROXYETHOXY)-4-METHOXYPHENYL)-1-(3,4-(METHYLENEDIOXY)PHENYL)-5-PROPOXY-2-INDANCARBOXYLIC ACID
SB-217242
experimental_condition_ontology
XCO:0000729
enrasentan
XCO:0000729
Enrasentan is an orally active mixed endothelin A/B receptor antagonist with a 100-fold greater affinity for the endothelin A receptor.
https://drugs.ncats.io/drug/QG16H8A6ZH
Any condition in which the main influencing factor is an agent that blocks one or more endothelin receptors.
slaulede
2020-07-27T15:48:37Z
CHEBI:51451
endothelin receptor blocker
experimental_condition_ontology
XCO:0000730
endothelin receptor antagonist
XCO:0000730
Any condition in which the main influencing factor is an agent that blocks one or more endothelin receptors.
XCO:0000536
A regimen of solid food in which the amount of enrasentan consumed is controlled.
slaulede
2020-07-27T16:09:03Z
RGD:36174026
controlled SB-217242 content diet
experimental_condition_ontology
XCO:0000731
controlled enrasentan content diet
XCO:0000731
A regimen of solid food in which the amount of enrasentan consumed is controlled.
RGD:36174026
A condition in which the main influencing factor is CC531, a rat colonic adenocarcinoma cell line used to study metastasis.
slaulede
2020-08-18T16:56:25Z
PMID:8225852
RRID:CVCL_0206
CC-531
experimental_condition_ontology
XCO:0000732
CC531 cells
XCO:0000732
A benzophenanthridine alkaloid derived from Sanguinaria canadensis and poppy Fumaria species, shown to exhibit anti-microbial, anti-tumoral, and anti-inflammatory activities.
slaulede
2020-09-04T16:56:22Z
CHEBI:17183
MESH:C005705
13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridinium
pseudochelerythrine
experimental_condition_ontology
XCO:0000733
sanguinarine
XCO:0000733
A benzophenanthridine alkaloid derived from Sanguinaria canadensis and poppy Fumaria species, shown to exhibit anti-microbial, anti-tumoral, and anti-inflammatory activities.
CHEBI:17183
PMID:21849887
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/sanguinarine
A potent chemokine-like receptor 1 (CMKLR1) agonist that corresponds to C-terminal of full length human Chemerin (RARRES2), amino acids 149 - 157. Activates Gi/o signaling pathways in vitro; inhibits cAMP production and promotes phospholipase C production, Ca2+ mobilization, and smooth muscle contraction.
slaulede
2020-09-04T17:26:44Z
PMID:29906243
(149)YFPGQFAFS(157)
YFPGQFAFS
experimental_condition_ontology
XCO:0000734
chemerin-9
XCO:0000734
A potent chemokine-like receptor 1 (CMKLR1) agonist that corresponds to C-terminal of full length human Chemerin (RARRES2), amino acids 149 - 157. Activates Gi/o signaling pathways in vitro; inhibits cAMP production and promotes phospholipase C production, Ca2+ mobilization, and smooth muscle contraction.
PMID:29906243
RGD:1320450
https://www.rndsystems.com/products/chemerin-9-human_7116
A tetracyclic diterpenoid which is a mitotic inhibitor used in cancer chemotherapy.
slaulede
2020-09-08T14:14:00Z
CHEBI:45863
MESH:D017239
Taxol
experimental_condition_ontology
XCO:0000735
paclitaxel
XCO:0000735
A tetracyclic diterpenoid which is a mitotic inhibitor used in cancer chemotherapy.
CHEBI:45863
An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that can cause a localized infection of mucous membranes or skin (diphtheria), myocarditis, polyneuritis, and other systemic toxic effects.
slaulede
2020-09-08T17:35:42Z
DOID:11405
MESH:D004165
DT
experimental_condition_ontology
XCO:0000736
diphtheria toxin
XCO:0000736
An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that can cause a localized infection of mucous membranes or skin (diphtheria), myocarditis, polyneuritis, and other systemic toxic effects.
DOID:11405
MESH:D004165
A component of bacterial cells, an endotoxin can be a part of the outer membrane of gram-negative bacteria (lipopolysacharride) or a part or the "spore" of gram-positive bacteria (delta endotoxin).
slaulede
2020-09-14T17:54:49Z
experimental_condition_ontology
XCO:0000737
endotoxin
XCO:0000737
A component of bacterial cells, an endotoxin can be a part of the outer membrane of gram-negative bacteria (lipopolysacharride) or a part or the "spore" of gram-positive bacteria (delta endotoxin).
PMID:11468393
https://www.horseshoecrab.org/med/endotoxin.html
This most common type of endotoxin is found in the outer membrane of gram-negative bacteria. Lipopolysaccharide consists of the lipid A portion containing fatty acids and disaccharide phosphates, core polysaccharides, and the O-antigen (repetitive glycan polymer).
slaulede
2020-09-14T18:06:38Z
endotoxin
LPS
experimental_condition_ontology
XCO:0000738
lipopolysaccharide
XCO:0000738
This most common type of endotoxin is found in the outer membrane of gram-negative bacteria. Lipopolysaccharide consists of the lipid A portion containing fatty acids and disaccharide phosphates, core polysaccharides, and the O-antigen (repetitive glycan polymer).
PMID:8119492
https://www.horseshoecrab.org/med/endotoxin.html
This is any condition in which the main influencing factor is housing in trios, a sutuation where subjects are housed in groups of three during a specified time period(s).
slaulede
2020-09-15T14:52:57Z
experimental_condition_ontology
XCO:0000739
housing in trios
XCO:0000739
This is any condition in which the main influencing factor is housing in trios, a sutuation where subjects are housed in groups of three during a specified time period(s).
PMID:16197708
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is housing with pathogen-infected subject(s), a situation in which at least one subject in the housing had a pathogenic infection during the time period leading up to the specified housing period.
slaulede
2020-09-15T15:27:06Z
experimental_condition_ontology
XCO:0000740
housing with pathogen-infected subject
XCO:0000740
This is any condition in which the main influencing factor is housing with pathogen-infected subject(s), a situation in which at least one subject in the housing had a pathogenic infection during the time period leading up to the specified housing period.
PMID:16197708
https://www.merriam-webster.com/
A condition in which subjects are maintained in housing groups in which at least one subject had a bacterial pathogenic infection during the time period leading up to the specified housing period.
slaulede
2020-09-15T15:31:42Z
experimental_condition_ontology
XCO:0000741
housing with bacterial pathogen-infected subject
XCO:0000741
A condition in which subjects are maintained in housing groups in which at least one subject had a bacterial pathogenic infection during the time period leading up to the specified housing period.
PMID:16197708
https://www.merriam-webster.com/
A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus infection during the time period leading up to the specified housing period. Haemophilus is a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic.
slaulede
2020-09-15T15:38:24Z
experimental_condition_ontology
XCO:0000742
housing with Haemophilus-infected subject
XCO:0000742
A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus infection during the time period leading up to the specified housing period. Haemophilus is a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic.
PMID:16197708
https://www.merriam-webster.com/
A condition in which the primary influencing factor is a species of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic.
slaulede
2020-09-15T15:47:23Z
experimental_condition_ontology
XCO:0000743
Haemophilus
XCO:0000743
A condition in which the primary influencing factor is a species of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic.
PMID:16197708
https://en.wikipedia.org/wiki/Haemophilus
https://www.merriam-webster.com/
A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus H21 infection during the time period leading up to the specified housing period. Haemophilus H21 is a strain of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic.
slaulede
2020-09-15T16:42:53Z
experimental_condition_ontology
XCO:0000744
housing with Haemophilus H21-infected subject
XCO:0000744
A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus H21 infection during the time period leading up to the specified housing period. Haemophilus H21 is a strain of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic.
PMID:16197708
https://www.merriam-webster.com/
A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus H35 infection during the time period leading up to the specified housing period. Haemophilus H35 is a strain of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic.
slaulede
2020-09-15T16:46:22Z
experimental_condition_ontology
XCO:0000745
housing with Haemophilus H35-infected subject
XCO:0000745
A condition in which subjects are maintained in housing groups in which at least one subject had a Haemophilus H35 infection during the time period leading up to the specified housing period. Haemophilus H35 is a strain of Haemophilus, a genus of Gram-negative, coccobacilli bacteria, some of which are pathogenic.
PMID:16197708
https://www.merriam-webster.com/
A condition in which subjects are maintained in housing groups in which at least one subject had a Pasteurella pneumotropica infection during the time period leading up to the specified housing period. Pasteurella pneumotropica is a strain of Pasteurella, a genus Gram-negative, coccobacilli bacteria, some of which are pathogenic.
slaulede
2020-09-15T17:00:42Z
experimental_condition_ontology
XCO:0000746
housing with Pasteurella pneumotropica-infected subject
XCO:0000746
A condition in which subjects are maintained in housing groups in which at least one subject had a Pasteurella pneumotropica infection during the time period leading up to the specified housing period. Pasteurella pneumotropica is a strain of Pasteurella, a genus Gram-negative, coccobacilli bacteria, some of which are pathogenic.
PMID:16197708
https://www.uptodate.com/contents/pasteurella-infections
A condition in which subjects are maintained in housing groups in which at least one subject had a Pasteurellaceae infection during the time period leading up to the specified housing period. Pasteurellaceae is a large family of Gram-negative bacteria including the genera Pasteurella and Haemophilus, some of which are pathogenic.
slaulede
2020-09-15T17:15:32Z
experimental_condition_ontology
XCO:0000747
housing with Pasteurellaceae-infected subject
XCO:0000747
A condition in which subjects are maintained in housing groups in which at least one subject had a Pasteurellaceae infection during the time period leading up to the specified housing period. Pasteurellaceae is a large family of Gram-negative bacteria including the genera Pasteurella and Haemophilus, some of which are pathogenic.
PMID:16197708
https://en.wikipedia.org/wiki/Pasteurellaceae
Any condition in which the main influencing factor is a substance which decreases or interferes with the activity of a protease, any of numerous enzymes that hydrolyze proteins.
slaulede
2020-09-22T15:03:07Z
proteinase inhibitor
experimental_condition_ontology
peptidase inhibitor
XCO:0000748
protease inhibitor
XCO:0000748
Any condition in which the main influencing factor is a substance which decreases or interferes with the activity of a protease, any of numerous enzymes that hydrolyze proteins.
ISBN-13:978-0877798071
ISBN-13:978-1416062578
Any condition in which the main influencing factor is phosphoramidon, a potent inhibitor of thermolysin and other metallo-endopeptidases, isolated from the cultures of Streptomyces tanashiensis.
slaulede
2020-09-22T15:31:08Z
CHEBI:45353
MESH:C008890
experimental_condition_ontology
XCO:0000749
phosphoramidon
XCO:0000749
Any condition in which the main influencing factor is phosphoramidon, a potent inhibitor of thermolysin and other metallo-endopeptidases, isolated from the cultures of Streptomyces tanashiensis.
CHEBI:45353
https://www.sigmaaldrich.com/catalog/product/sigma/r7385?lang=en®ion=US
This is any condition in which the main influencing factor is diclofenac, a monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position. It is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
slaulede
2020-09-25T10:32:53Z
CHEBI:47381
CID:3033
MESH:D004008
PMID:32119089
Diclofenac acid
Voltaren
experimental_condition_ontology
XCO:0000750
diclofenac
XCO:0000750
This is any condition in which the main influencing factor is diclofenac, a monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position. It is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
CHEBI:47381
MESH:D004008
A surgical manipulation causing blockage of one of the common carotid arteries, or of a branch (internal or external) of the common carotid arteries.
slaulede
2020-09-25T13:30:19Z
PMID:29486300
UCAO
experimental_condition_ontology
XCO:0000751
unilateral carotid artery occlusion
XCO:0000751
A surgical manipulation causing blockage of one of the common carotid arteries, or of a branch (internal or external) of the common carotid arteries.
ISBN-13:978-0323049375
PMID:29486300
A surgical manipulation causing blockage of the right common carotid artery, or a branch (internal or external) of the right common carotid artery.
slaulede
2020-09-25T13:54:07Z
experimental_condition_ontology
XCO:0000752
right carotid artery occlusion
XCO:0000752
A surgical manipulation causing blockage of the right common carotid artery, or a branch (internal or external) of the right common carotid artery.
ISBN-13:978-0323049375
PMID:29486300
A surgical manipulation causing blockage of the left common carotid artery, or a branch (internal or external) of the left common carotid artery.
slaulede
2020-09-25T14:00:57Z
experimental_condition_ontology
XCO:0000753
left carotid artery occlusion
XCO:0000753
A surgical manipulation causing blockage of the left common carotid artery, or a branch (internal or external) of the left common carotid artery.
ISBN-13:978-0323049375
PMID:31482584
A surgical manipulation causing blockage of both of the common carotid arteries, or left and right branches (internal or external) of the common carotid arteries.
slaulede
2020-09-25T14:09:32Z
BCCAo
bilateral common carotid artery occlusion
experimental_condition_ontology
XCO:0000754
bilateral carotid artery occlusion
XCO:0000754
A surgical manipulation causing blockage of both of the common carotid arteries, or left and right branches (internal or external) of the common carotid arteries.
ISBN-13:978-0323049375
PMID:32937001
Any condition in which the main influencing factor is dimethyl sulfoxide, a 2-carbon sulfoxide and highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
slaulede
2020-09-25T14:25:59Z
CHEBI:28262
MESH:D004121
DMSO
experimental_condition_ontology
XCO:0000755
dimethyl sulfoxide
XCO:0000755
Any condition in which the main influencing factor is dimethyl sulfoxide, a 2-carbon sulfoxide and highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
CHEBI:28262
MESH:D004121
This is any condition in which the main influencing factor is Kolliphor HS 15, a non-ionic surfactant and emulsifier that is a potential therapeutic agent because of its effectiveness for reversing multidrug resistance in vitro and its low toxicity in vivo.
slaulede
2020-09-25T14:43:25Z
CHEBI:9194
Macrogol (15)-hydroxystearate
Polyethylene glycol (15)-hydroxystearate
Polyoxyethylated 12-hydroxystearic acid
Solutol
Solutol HS 15
experimental_condition_ontology
XCO:0000756
Kolliphor HS 15
XCO:0000756
This is any condition in which the main influencing factor is Kolliphor HS 15, a non-ionic surfactant and emulsifier that is a potential therapeutic agent because of its effectiveness for reversing multidrug resistance in vitro and its low toxicity in vivo.
PMID:1988130
https://www.sigmaaldrich.com/catalog/papers/1988130
A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapor and/or at other interfaces.
slaulede
2020-09-25T15:01:23Z
experimental_condition_ontology
XCO:0000757
surfactant
XCO:0000757
A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapor and/or at other interfaces.
CHEBI:35195
https://www.merriam-webster.com/dictionary/surfactant
Condition in which the main influencing factor is retinoic acid, a retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified). Retinoic acid is derived from retinol (vitamin A) and plays important roles in cell growth, differentiation, and organogenesis.
slaulede
2020-10-05T16:57:15Z
CHEBI:26536
PMID:22439772
experimental_condition_ontology
XCO:0000758
retinoic acid
XCO:0000758
Condition in which the main influencing factor is retinoic acid, a retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified). Retinoic acid is derived from retinol (vitamin A) and plays important roles in cell growth, differentiation, and organogenesis.
CHEBI:26536
PMID:22439772
A condition in which the major influencing factor is a soluble Schistosoma mansoni protein expressed by the schistosomulum and target of cytotoxic IgE antibodies.
slaulede
2020-10-13T18:01:28Z
experimental_condition_ontology
XCO:0000760
26 kDa Schistosoma mansoni antigen
XCO:0000760
A condition in which the major influencing factor is a soluble Schistosoma mansoni protein expressed by the schistosomulum and target of cytotoxic IgE antibodies.
PMID:1719096
PMID:6698106
Any condition in which the main influencing factor is a biologic (product of, or component of, a living organism) or probiotic introduced externally or internally to a subject to effect a change in phenotype of the subject, usually in treatment of a medical condition. Probiotics are live microorganisms that are intended to have health benefits when consumed or applied to the body.
slaulede
2020-10-15T17:39:53Z
biological medical product
biopharmaceutical
experimental_condition_ontology
XCO:0000761
biologics and probiotics
XCO:0000761
Any condition in which the main influencing factor is a biologic (product of, or component of, a living organism) or probiotic introduced externally or internally to a subject to effect a change in phenotype of the subject, usually in treatment of a medical condition. Probiotics are live microorganisms that are intended to have health benefits when consumed or applied to the body.
https://www.fda.gov/about-fda/center-biologics-evaluation-and-research-cber/what-are-biologics-questions-and-answers
https://www.merriam-webster.com/
https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know
Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies.
slaulede
2020-10-15T17:53:02Z
PMID:1719096
PMID:2494262
experimental_condition_ontology
XCO:0000762
rat anti-Ab2 T cells
XCO:0000762
Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies.
PMID:1719096
PMID:2494262
Any condition in which the main influencing factor is an injection of T cells (T lymphocytes). T cells are integral to the functioning of the immune system and are at the core of adaptive immunity, the system that tailors the body's immune response to specific pathogens
slaulede
2020-10-15T18:06:48Z
experimental_condition_ontology
XCO:0000763
T cells
XCO:0000763
Any condition in which the main influencing factor is an injection of T cells (T lymphocytes). T cells are integral to the functioning of the immune system and are at the core of adaptive immunity, the system that tailors the body's immune response to specific pathogens
CL:0000084
https://www.medicinenet.com/script/main/art.asp?articlekey=11300
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies.
slaulede
2020-10-16T15:00:38Z
PMID:1719096
PMID:2494262
experimental_condition_ontology
XCO:0000764
rat anti-Ab2 T cell line
XCO:0000764
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies.
PMID:1719096
PMID:2494262
https://www.merriam-webster.com/
Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni .
slaulede
2020-10-16T16:53:18Z
experimental_condition_ontology
XCO:0000765
rat anti-26 kDa T cells
XCO:0000765
Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni .
PMID:1719096
https://www.merriam-webster.com/
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni.
slaulede
2020-10-16T16:59:07Z
experimental_condition_ontology
XCO:0000766
rat anti-26 kDa T cell line
XCO:0000766
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni.
PMID:1719096
https://www.merriam-webster.com/
A condition in which the main influencing factor is Schistosoma mansoni, a trematode parasite that lives in certain types of freshwater snails. The infectious form of the parasite, known as cercariae, emerge from the snail into the water. Humans can become infected when skin comes in contact with contaminated freshwater.
slaulede
2020-10-16T17:29:53Z
experimental_condition_ontology
XCO:0000767
Schistosoma mansoni
XCO:0000767
A condition in which the main influencing factor is Schistosoma mansoni, a trematode parasite that lives in certain types of freshwater snails. The infectious form of the parasite, known as cercariae, emerge from the snail into the water. Humans can become infected when skin comes in contact with contaminated freshwater.
PMID:1719096
https://www.cdc.gov/parasites/schistosomiasis/index.html
A condition in which the main influencing factor is the infective cercariae (larvae) of the trematode parasite Schistosoma mansoni.
slaulede
2020-10-16T17:50:16Z
experimental_condition_ontology
XCO:0000768
Schistosoma mansoni cercariae
XCO:0000768
A condition in which the main influencing factor is the infective cercariae (larvae) of the trematode parasite Schistosoma mansoni.
PMID:1719096
https://www.britannica.com/science/cercaria
Blood serum that contains antibodies against an infective agent (such as a bacteria or virus) or toxic substance (such as snake venom) and may be used to prevent or treat infection or poisoning.
slaulede
2020-10-19T13:58:56Z
experimental_condition_ontology
XCO:0000769
antiserum
XCO:0000769
Blood serum that contains antibodies against an infective agent (such as a bacteria or virus) or toxic substance (such as snake venom) and may be used to prevent or treat infection or poisoning.
https://www.biologyonline.com/dictionary/antiserum
https://www.merriam-webster.com/
Any condition in which the main influencing factor is serum prepared from rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies.
slaulede
2020-10-19T14:05:35Z
PMID:1719096
experimental_condition_ontology
XCO:0000770
rat anti-Ab2 antiserum
XCO:0000770
Any condition in which the main influencing factor is serum prepared from rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against anti-26 kDa (antigen secreted from schistosomula of Schistosoma mansoni) IgE antibodies.
PMID:1719096
https://www.merriam-webster.com/
Any condition in which the main influencing factor is serum prepared from rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni.
slaulede
2020-10-19T14:09:02Z
PMID:1719096
experimental_condition_ontology
XCO:0000771
rat anti-26 kDa antiserum
XCO:0000771
Any condition in which the main influencing factor is serum prepared from rats immunized with the 26 kDa antigen secreted from schistosomula of Schistosoma mansoni.
PMID:1719096
https://www.merriam-webster.com/
A solid diet in which the amount of cocoa butter is maintained at a specified level. Cocoa butter is a pale vegetable fat with a low melting point obtained from cacao beans.
slaulede
2020-10-19T15:39:19Z
experimental_condition_ontology
XCO:0000772
controlled cocoa butter content diet
XCO:0000772
A solid diet in which the amount of cocoa butter is maintained at a specified level. Cocoa butter is a pale vegetable fat with a low melting point obtained from cacao beans.
https://www.healthline.com/health/beauty-skin-care/cocoa-butter-benefits
https://www.merriam-webster.com/
A solid diet in which the amount of soybean oil is maintained at a specified level. Soybean oil is a pale yellow drying or semidrying oil that is obtained from soybeans and is used chiefly as a food, in paints, varnishes, linoleum, printing ink, and soap, and as a source of phospholipids, fatty acids, and sterols.
slaulede
2020-10-19T17:46:26Z
experimental_condition_ontology
XCO:0000773
controlled soybean oil content diet
XCO:0000773
A solid diet in which the amount of soybean oil is maintained at a specified level. Soybean oil is a pale yellow drying or semidrying oil that is obtained from soybeans and is used chiefly as a food, in paints, varnishes, linoleum, printing ink, and soap, and as a source of phospholipids, fatty acids, and sterols.
https://www.merriam-webster.com/
https://www.webmd.com/vitamins/ai/ingredientmono-196/soybean-oil
Any condition in which the main influencing factor is any of numerous unctuous combustible substances that are liquid or can be liquefied easily on warming, are soluble in ether but not in water, and leave a greasy stain on paper or cloth.
slaulede
2020-10-19T18:03:59Z
experimental_condition_ontology
XCO:0000774
oil
XCO:0000774
Any condition in which the main influencing factor is any of numerous unctuous combustible substances that are liquid or can be liquefied easily on warming, are soluble in ether but not in water, and leave a greasy stain on paper or cloth.
ISBN:978-1-4684-6878-6
https://www.britannica.com/science/oil-chemical-compound
https://www.merriam-webster.com/
Any condition in which the main influencing factor is soybean oil. Soybean oil is a pale yellow drying or semidrying oil that is obtained from soybeans and is used chiefly as a food, in paints, varnishes, linoleum, printing ink, and soap, and as a source of phospholipids, fatty acids, and sterols.
slaulede
2020-10-19T18:21:13Z
experimental_condition_ontology
XCO:0000775
soybean oil
XCO:0000775
Any condition in which the main influencing factor is soybean oil. Soybean oil is a pale yellow drying or semidrying oil that is obtained from soybeans and is used chiefly as a food, in paints, varnishes, linoleum, printing ink, and soap, and as a source of phospholipids, fatty acids, and sterols.
https://www.merriam-webster.com/
https://www.webmd.com/vitamins/ai/ingredientmono-196/soybean-oil
This is any condition in which the main influencing factor is an aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax.
slaulede
2020-10-19T18:27:54Z
CHEBI:35366
experimental_condition_ontology
XCO:0000776
fatty acid
XCO:0000776
This is any condition in which the main influencing factor is an aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax.
CHEBI:35366
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is alpha-lipoic acid, a heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
slaulede
2020-10-19T18:33:37Z
CHEBI:16494
MESH:D008063
PMID:30208622
α-lipoic acid
LA
Thioctic Acid
alpha-lipoic acid
experimental_condition_ontology
XCO:0000777
lipoic acid
XCO:0000777
This is any condition in which the main influencing factor is alpha-lipoic acid, a heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
CHEBI:16494
MESH:D008063
A condition in which the main influencing factor is spiroplatin, a metal drug and analog of the second generation for cisplatin, developed for the treatment of cancer. Spiroplatin induces DNA cross-linking, thereby inhibiting DNA replication and the synthesis of RNA and protein. Initial clinical trials of spiroplatin showed that it could cause less nausea and vomiting than cisplatin, but development was discontinued due to weak anti-tumor effects and toxicity at high dosages.
slaulede
2020-10-20T14:53:27Z
MESH:C040757
NSC-311056
TNO-6
aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum (II)
experimental_condition_ontology
XCO:0000778
spiroplatin
XCO:0000778
A condition in which the main influencing factor is spiroplatin, a metal drug and analog of the second generation for cisplatin, developed for the treatment of cancer. Spiroplatin induces DNA cross-linking, thereby inhibiting DNA replication and the synthesis of RNA and protein. Initial clinical trials of spiroplatin showed that it could cause less nausea and vomiting than cisplatin, but development was discontinued due to weak anti-tumor effects and toxicity at high dosages.
MESH:C040757
https://drugs.ncats.io/drug/H2V318W7LE
A condition in which the main influencing factor is rat IgM-secreting immunocytoma cells. The transplantable tumor cells are used in various studies including antibody secretion studies and antitumoral drug studies.
slaulede
2020-10-22T13:12:29Z
PMID:6683993
rat IgM lymphoplasmacytic lymphoma cells
experimental_condition_ontology
XCO:0000779
rat IgM immunocytoma cells
XCO:0000779
A condition in which the main influencing factor is rat IgM-secreting immunocytoma cells. The transplantable tumor cells are used in various studies including antibody secretion studies and antitumoral drug studies.
DOID:0050747
PMID:6683993
An experimental condition in which the main influencing factor is liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances.
slaulede
2020-10-27T16:40:20Z
PMID:6744286
experimental_condition_ontology
XCO:0000780
liposomes
XCO:0000780
An experimental condition in which the main influencing factor is liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances.
https://www.merriam-webster.com/
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposome
An experimental condition in which the main influencing factor is positively charged liposomes, artificial positively charged vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances.
slaulede
2020-10-27T16:48:40Z
PMID:6744286
lip+
experimental_condition_ontology
XCO:0000781
positively charged liposomes
XCO:0000781
An experimental condition in which the main influencing factor is positively charged liposomes, artificial positively charged vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances.
PMID:6744286
https://www.merriam-webster.com/
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposome
An experimental condition in which the main influencing factor is negatively charged liposomes, artificial negatively charged vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances.
slaulede
2020-10-27T16:52:12Z
PMID:6744286
lip-
experimental_condition_ontology
XCO:0000782
negatively charged liposomes
XCO:0000782
An experimental condition in which the main influencing factor is negatively charged liposomes, artificial negatively charged vesicles composed of one or more concentric phospholipid bilayers and used to deliver biologically relevant substances.
PMID:6744286
https://www.merriam-webster.com/
https:www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposome
This is any condition in which the main influencing factor is a cytokine, a small secreted protein that has a specific effect on the interactions and communications between cells. Cytokine is a general name for other signaling molecules, including lymphokines, monokines, and chemokines.
slaulede
2020-10-30T13:38:35Z
chemokine
lymphokine
monokine
experimental_condition_ontology
XCO:0000783
cytokine
XCO:0000783
This is any condition in which the main influencing factor is a cytokine, a small secreted protein that has a specific effect on the interactions and communications between cells. Cytokine is a general name for other signaling molecules, including lymphokines, monokines, and chemokines.
ISBN-13:978-1608316922
PMID:17426506
This is any condition in which the main influencing factor is interleukin-2, a cytokine made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system.
slaulede
2020-10-30T13:52:50Z
MESH:D007376
IL-2
IL2
interleukin 2
experimental_condition_ontology
XCO:0000784
interleukin-2
XCO:0000784
This is any condition in which the main influencing factor is interleukin-2, a cytokine made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system.
ISBN-13:978-1608316922
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/interleukin-2
A condition in which the main influencing factor is a rat cell line derived from a colonic adenocarcinoma induced by 1,2- dimethylhydrazine in BDIX rats.
slaulede
2020-10-30T14:41:50Z
PMID:6358055
PMID:9833767
experimental_condition_ontology
XCO:0000785
PROb cells
XCO:0000785
A condition in which the main influencing factor is a rat cell line derived from a colonic adenocarcinoma induced by 1,2- dimethylhydrazine in BDIX rats.
PMID:6358055
PMID:9833767
A rat cell line (PROb 5-FU-resistant subline) derived from colonic adenocarcinoma PROb cells. The R1 cell line was established from PROb cells by in vivo and in vitro adaptation to 5-fluorouracil (5-FU), an anticancer drug.
slaulede
2020-10-30T14:51:26Z
PMID:9399677
PMID:9833767
experimental_condition_ontology
XCO:0000786
PRObR1 cells
XCO:0000786
A rat cell line (PROb 5-FU-resistant subline) derived from colonic adenocarcinoma PROb cells. The R1 cell line was established from PROb cells by in vivo and in vitro adaptation to 5-fluorouracil (5-FU), an anticancer drug.
PMID:9399677
PMID:9833767
Any condition in which the main influencing factor is sodium butyrate, an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid (a short-chain fatty acid) by a sodium ion.
slaulede
2020-10-30T14:59:55Z
CHEBI:64103
MESH:D002087
sodium butanoate
experimental_condition_ontology
XCO:0000787
sodium butyrate
XCO:0000787
Any condition in which the main influencing factor is sodium butyrate, an organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid (a short-chain fatty acid) by a sodium ion.
CHEBI:64103
MESH:D002087
A condition in which the main influencing factor is a rat rhabdomyosarcoma cell line used to study metastasis.
slaulede
2020-11-12T16:13:47Z
PMID:18028954
experimental_condition_ontology
XCO:0000788
S4MH cells
XCO:0000788
A condition in which the main influencing factor is a rat rhabdomyosarcoma cell line used to study metastasis.
ISBN-13:978-0781733908
PMID:18028954
This is any condition in which the main influencing factor is methylcellulose, a methylester of cellulose used as an emulsifying and suspending agent in cosmetics, pharmaceuticals and the chemical industry. It is used therapeutically as a bulk laxative.
slaulede
2020-11-16T14:59:35Z
Citrucel
MC
methyl cellulose
experimental_condition_ontology
XCO:0000789
methylcellulose
XCO:0000789
This is any condition in which the main influencing factor is methylcellulose, a methylester of cellulose used as an emulsifying and suspending agent in cosmetics, pharmaceuticals and the chemical industry. It is used therapeutically as a bulk laxative.
CHEBI:53448
MESH:D008747
A drink made up of water and a specified amount of sodium chloride dissolved in a sufficient quantity of water.
slaulede
2020-11-19T14:53:13Z
controlled NaCl content drinking water
experimental_condition_ontology
XCO:0000790
controlled sodium chloride content drinking water
XCO:0000790
A drink made up of water and a specified amount of sodium chloride dissolved in a sufficient quantity of water.
https://www.merriam-webster.com/
A condition defined by a mostly uniform set of parameters accepted as normal or average and used by general consent as a basis of comparison.
slaulede
2020-11-30T14:00:43Z
experimental_condition_ontology
XCO:0000791
standard condition
true
XCO:0000791
A condition defined by a mostly uniform set of parameters accepted as normal or average and used by general consent as a basis of comparison.
https://www.dictionary.com
https://www.merriam-webster.com/
A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
slaulede
2020-11-30T18:03:20Z
CHEBI:42223
MESH:D004642
PMID:31983185
experimental_condition_ontology
XCO:0000792
emodin
XCO:0000792
A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
CHEBI:42223
This is an in-silico screening analog of emodin (XCO:0000792).
slaulede
2020-11-30T18:19:37Z
PMID:31983185
BTB 14431
experimental_condition_ontology
XCO:0000793
BTB14431
XCO:0000793
This is an in-silico screening analog of emodin (XCO:0000792).
PMID:31983185
A condition in which the lin-28 homolog B gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
slaulede
2020-12-01T17:05:51Z
PMID:27384999
adenoviral transfer of the Lin28B gene
gene transfer of the Lin28B gene using an adenovirus vector
transfer of recombinant adenovirus containing the Lin28B gene
experimental_condition_ontology
Ad/Lin28B
XCO:0000794
gene transfer of the lin-28 homolog B gene using an adenovirus vector
XCO:0000794
A condition in which the lin-28 homolog B gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
ISBN-13:978-0781733908
PMID:24279313
A regimen of solid food in which the amount of sodium chloride consumed is controlled.
slaulede
2020-12-18T17:49:31Z
controlled NaCl content diet
experimental_condition_ontology
XCO:0000795
controlled sodium chloride content diet
XCO:0000795
A regimen of solid food in which the amount of sodium chloride consumed is controlled.
https://www.merriam-webster.com/
A prostaglandin endoperoxide analogue (11,9 epoxymethano-prostaglandin H2) that is a selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2) (TP) receptor. It is a stable thromboxane A2 mimetic and a vasoconstrictor.
slaulede
2021-01-04T16:46:45Z
CAS:56985-40-1
PMID:22508433
9,11-Dideoxy-9α,11α-methanoepoxyprostaglandin F 2α
U 46619
experimental_condition_ontology
XCO:0000796
U46619
XCO:0000796
A prostaglandin endoperoxide analogue (11,9 epoxymethano-prostaglandin H2) that is a selective agonist of prostaglandin H2 (PGH2)/thromboxane A2 (TxA2) (TP) receptor. It is a stable thromboxane A2 mimetic and a vasoconstrictor.
http://www.apexbt.com
https://www.sigmaaldrich.com
A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It is a cell-permeable, reversible inhibitor of Rho-associated protein kinase (ROCK) enzyme.
slaulede
2021-01-04T16:52:50Z
CAS:146986-50-7
MESH:C108830
PMID:22508433
ROCK Inhibitor
Rho-associated protein kinase Inhibitor
Y 27632
Y27632
experimental_condition_ontology
XCO:0000797
Y-27632
XCO:0000797
A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It is a cell-permeable, reversible inhibitor of Rho-associated protein kinase (ROCK) enzyme.
CHEBI:75393
https://www.sigmaaldrich.com
Generated from the gene PNOC, which produces a preproprotein, which in subsequently processed to form multiple protein products. Nociceptin a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity.
slaulede
2021-02-08T16:43:57Z
PMID:17875345
NOP
OFQ
orphanin FQ
experimental_condition_ontology
XCO:0000798
nociceptin
XCO:0000798
Generated from the gene PNOC, which produces a preproprotein, which in subsequently processed to form multiple protein products. Nociceptin a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity.
https://www.ncbi.nlm.nih.gov/gene/5368
This is any condition in which the main influencing factor is ether, a mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums.
slaulede
2021-02-08T16:54:25Z
CHEBI:25698he
CID:3283
D004986
(C2H5)2O
C4H10O
CH3CH2OCH2CH3
Diethyl ether
Ethyl ether
experimental_condition_ontology
XCO:0000799
ether
XCO:0000799
This is any condition in which the main influencing factor is ether, a mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums.
MESH:D004986
https://www.merriam-webster.com/
Any condition in which the main influencing factor is a particle with a size between 1 and 100 nanometers composed of iron oxide (Fe3O4). It contains both Fe2+ and Fe3+ ions and is sometimes formulated as FeO ∙ Fe2O3. It exhibits permanent magnetism and is ferrimagnetic.
slaulede
2021-02-09T12:06:12Z
PMID:22661893
Fe3O4 nanoparticles
Iron(II,III)oxide nanoparticles
MNPs
magnetic nanoparticles
experimental_condition_ontology
XCO:0000800
iron oxide nanoparticles
XCO:0000800
Any condition in which the main influencing factor is a particle with a size between 1 and 100 nanometers composed of iron oxide (Fe3O4). It contains both Fe2+ and Fe3+ ions and is sometimes formulated as FeO ∙ Fe2O3. It exhibits permanent magnetism and is ferrimagnetic.
https://en.wikipedia.org/wiki/Iron(II,III)_oxide
https://pubchem.ncbi.nlm.nih.gov/compound/Iron_II_III_oxide
A regimen of solid food in which the amount of gliadin consumed is controlled. Gliadins are a group of proteins called alpha, beta, gamma and omega according to their relative electrophoretic mobility in gels. They are the major component of wheat gluten and made up of single-chain polypeptides with an average molecular weight of 25–100 kDa linked by intramolecular disulfide bonds.
slaulede
2021-02-09T12:53:16Z
PMID:19327106
experimental_condition_ontology
XCO:0000801
controlled gliadin content diet
XCO:0000801
A regimen of solid food in which the amount of gliadin consumed is controlled. Gliadins are a group of proteins called alpha, beta, gamma and omega according to their relative electrophoretic mobility in gels. They are the major component of wheat gluten and made up of single-chain polypeptides with an average molecular weight of 25–100 kDa linked by intramolecular disulfide bonds.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gliadin
It is a tertiary carboxamide and cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.
slaulede
2021-02-09T15:22:33Z
CAS:942206-85-1
PMID:29875065
pubchem.compound:23630211
C28H32Cl2N4O6S2
experimental_condition_ontology
XCO:0000802
GSK1016790A
XCO:0000802
It is a tertiary carboxamide and cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.
CHEBI:140524
Subthreshold therapy is photocoagulation that does not produce clinical or histologic evidence of retinal damage. Therapeutic benefit is thought to be derived by inducing thermal stress on RPE cells. The goal of the subthreshold therapy is to maintain the temperature rise below the threshold of irreversible thermal damage. The main types are micropulse, selective retinal therapy (SRT), and continuous wave laser with EndPoint Management (algorithm/protocol).
slaulede
2021-02-11T13:52:41Z
PMID:31402999
experimental_condition_ontology
XCO:0000803
subthreshold laser therapy
XCO:0000803
Subthreshold therapy is photocoagulation that does not produce clinical or histologic evidence of retinal damage. Therapeutic benefit is thought to be derived by inducing thermal stress on RPE cells. The goal of the subthreshold therapy is to maintain the temperature rise below the threshold of irreversible thermal damage. The main types are micropulse, selective retinal therapy (SRT), and continuous wave laser with EndPoint Management (algorithm/protocol).
PMID:27841848
https://eyewiki.aao.org/Sub-threshold_Laser#:~:text=Selective%20Retinal%20Therapy%20%28SRT%29%20Selective%20Retinal%20Therapy%20is,using%20laser%20pulse%20durations%20of%20microseconds%20or%20nanoseconds.
Any biomedical use of lasers for purposes designed to improve the state of the subject. Light from a laser is tuned to specific wavelengths and is a beam of coherent electromagnetic radiation usually in the ultraviolet, visible, or infrared regions of the spectrum.
slaulede
2021-02-11T14:10:41Z
MESH:D053685
PMID:31402999
experimental_condition_ontology
XCO:0000804
laser therapy
XCO:0000804
Any biomedical use of lasers for purposes designed to improve the state of the subject. Light from a laser is tuned to specific wavelengths and is a beam of coherent electromagnetic radiation usually in the ultraviolet, visible, or infrared regions of the spectrum.
https://www.healthline.com/health/laser-therapy
https://www.merriam-webster.com/
Nondamaging retinal laser therapy (NRT) is a retinal treatment with a lack of tissue damage. Lack of tissue damage allows high-density treatment patterns to increase therapeutic response and periodic retreatments for chronic macular diseases. It is similar to SRT (selective RPE therapy), but using lower energy to avoid killing retinal pigmented epithelial cells.
slaulede
2021-02-11T15:38:45Z
PMID:31402999
NRT
experimental_condition_ontology
XCO:0000805
nondamaging retinal laser therapy
XCO:0000805
Nondamaging retinal laser therapy (NRT) is a retinal treatment with a lack of tissue damage. Lack of tissue damage allows high-density treatment patterns to increase therapeutic response and periodic retreatments for chronic macular diseases. It is similar to SRT (selective RPE therapy), but using lower energy to avoid killing retinal pigmented epithelial cells.
PMID:27159441
Selective retinal therapy (SRT) is a subthreshold laser therapy used to treat retinal disorders while preventing severe damage to the retina. In SRT RPE (retinal pigment epithelium) cells are selectively damaged without affecting the photoreceptors or choroid by using laser pulse durations of microseconds or nanoseconds
slaulede
2021-02-11T17:14:59Z
PMID:31402999
SRT
selective RPE therapy
experimental_condition_ontology
XCO:0000806
selective retinal therapy
XCO:0000806
Selective retinal therapy (SRT) is a subthreshold laser therapy used to treat retinal disorders while preventing severe damage to the retina. In SRT RPE (retinal pigment epithelium) cells are selectively damaged without affecting the photoreceptors or choroid by using laser pulse durations of microseconds or nanoseconds
PMID:27841848
https://eyewiki.aao.org/Sub-threshold_Laser#:~:text=Selective%20Retinal%20Therapy%20%28SRT%29%20Selective%20Retinal%20Therapy%20is,using%20laser%20pulse%20durations%20of%20microseconds%20or%20nanoseconds.
A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. It is is a major herbal antioxidant and anti-inflammatory agent
slaulede
2021-02-16T16:28:33Z
CHEBI:67263
PMID:22212488
Sabiwhite
tetrahydrodiferuloylmethane
experimental_condition_ontology
XCO:0000807
tetrahydrocurcumin
XCO:0000807
A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. It is is a major herbal antioxidant and anti-inflammatory agent
CHEBI:67263
PMID:22212488
Any condition in which the main influencing factor is DL-α-aminoadipate. This excitatory amino acid analogue is an intermediate in the principal biosynthetic pathway of lysine. It is a also an inhibitor of glutamine synthetase.
slaulede
2021-02-16T17:08:36Z
CHEBI:37024
MESH:D015074
PMID:28615682
AAA
DL-α-AAA
dl-αAA
experimental_condition_ontology
XCO:0000808
DL-α-aminoadipate
XCO:0000808
Any condition in which the main influencing factor is DL-α-aminoadipate. This excitatory amino acid analogue is an intermediate in the principal biosynthetic pathway of lysine. It is a also an inhibitor of glutamine synthetase.
MESH:D015074
This is any condition in which the main influencing factor is 2-methyl-6-(phenylethynyl)pyridine, a methylpyridine that consists of 2-methylpyridine bearing an additional phenylethynyl group at position 6. It is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. It functions as an excitatory amino acid antagonist and an anxiolytic agent.
slaulede
2021-02-16T17:41:28Z
PMID:28615682
2-methyl-6-(phenylethynyl)pyridine
MPEP
experimental_condition_ontology
XCO:0000809
2-methyl-6-(phenylethynyl)pyridine
XCO:0000809
This is any condition in which the main influencing factor is 2-methyl-6-(phenylethynyl)pyridine, a methylpyridine that consists of 2-methylpyridine bearing an additional phenylethynyl group at position 6. It is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. It functions as an excitatory amino acid antagonist and an anxiolytic agent.
CHEBI:64159
MESH:C121465
Any condition in which the main influencing factor is 2-Chloro-5-hydroxyphenylglycine, a metabotropic glutamate receptor 5 agonist.
slaulede
2021-02-16T18:30:58Z
MESH:C107349
PMID:28615682
(R,S)-2-chloro- 5-hydroxyphenylglycine
CHPG
experimental_condition_ontology
XCO:0000810
2-Chloro-5-hydroxyphenylglycine
XCO:0000810
Any condition in which the main influencing factor is 2-Chloro-5-hydroxyphenylglycine, a metabotropic glutamate receptor 5 agonist.
PMID:28615682
This is any condition in which the main influencing factor is A23187, an ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes.
slaulede
2021-02-22T13:09:46Z
CHEBI:3305
MESH:D000001
PMID:22508433
A-23187
calcimycin
experimental_condition_ontology
XCO:0000811
A23187
XCO:0000811
This is any condition in which the main influencing factor is A23187, an ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes.
MESH:D000001
This is any condition in which the main influencing factor is controlled hemorrhage, the drawing of blood (by venipuncture or artery puncture) for transfusion, apheresis, diagnostic testing, or experimental procedures.
slaulede
2021-02-23T15:25:59Z
PMID:17998886
phlebotomy
experimental_condition_ontology
XCO:0000812
controlled hemorrhage
XCO:0000812
This is any condition in which the main influencing factor is controlled hemorrhage, the drawing of blood (by venipuncture or artery puncture) for transfusion, apheresis, diagnostic testing, or experimental procedures.
ISBN-13:978-0702033896
https://www.merriam-webster.com/
Total body irradiation (TBI) is a form of radiotherapy (typically X-rays or gamma rays) used primarily as part of the preparative regimen for hematopoietic stem cell (or bone marrow) transplantation.
slaulede
2021-03-02T14:21:45Z
ISBN-13:978-0323240987
PMID:30575429
TBI
experimental_condition_ontology
XCO:0000813
total body irradiation
XCO:0000813
Total body irradiation (TBI) is a form of radiotherapy (typically X-rays or gamma rays) used primarily as part of the preparative regimen for hematopoietic stem cell (or bone marrow) transplantation.
https://en.wikipedia.org/wiki/Total_body_irradiation
https://www.merriam-webster.com/
Partial body irradiation (PBI) is a form of radiotherapy used to target certain organs or to study the effects of sublethal doses of radiation.
slaulede
2021-03-02T14:31:47Z
PMID:22929471
PMID:27147332
PBI
experimental_condition_ontology
XCO:0000814
partial body irradiation
XCO:0000814
Partial body irradiation (PBI) is a form of radiotherapy used to target certain organs or to study the effects of sublethal doses of radiation.
PMID:22929471
PMID:27147332
This is a condition/model system that features partial body irradiation (PBI) delivering a high dose of radiation to most of the body, and a small fraction of that dose to one leg of the subject. It allows the study of multi-organ radiation injury while sparing the bone marrow from a lethal dose.
slaulede
2021-03-02T15:00:18Z
PMID:27682899
PMID:30575429
leg-out PBI
experimental_condition_ontology
XCO:0000815
leg-out partial body irradiation
XCO:0000815
This is a condition/model system that features partial body irradiation (PBI) delivering a high dose of radiation to most of the body, and a small fraction of that dose to one leg of the subject. It allows the study of multi-organ radiation injury while sparing the bone marrow from a lethal dose.
PMID:27682899
PMID:30575429
Partial-body irradiation with 5% bone marrow sparing (tibiae, ankles, feet) is used to define acute radiation-induced GI-ARS, H-ARS, and acute kidney injury (AKI) as well as the delayed effects of acute radiation exposure (DEARE) characterized by prolonged GI, lung, and heart injury and chronic kidney injury (CKI). This condition/model system allows analysis of concomitant multi-organ sequelae.
slaulede
2021-03-02T15:35:19Z
PMID:22929471
PMID:30575429
PBI/BM5
experimental_condition_ontology
XCO:0000816
partial-body irradiation with 5% bone marrow sparing
XCO:0000816
Partial-body irradiation with 5% bone marrow sparing (tibiae, ankles, feet) is used to define acute radiation-induced GI-ARS, H-ARS, and acute kidney injury (AKI) as well as the delayed effects of acute radiation exposure (DEARE) characterized by prolonged GI, lung, and heart injury and chronic kidney injury (CKI). This condition/model system allows analysis of concomitant multi-organ sequelae.
PMID:22929471
PMID:30575429
Whole thorax lung irradiation is a type of partial body irradiation used to target the lungs. In experimental animals it is used to study the lung morbidities caused by radiation exposure.
slaulede
2021-03-02T15:55:53Z
PMID:30575429
PMID:33009295
WTLI
experimental_condition_ontology
XCO:0000817
whole thorax lung irradiation
XCO:0000817
Whole thorax lung irradiation is a type of partial body irradiation used to target the lungs. In experimental animals it is used to study the lung morbidities caused by radiation exposure.
PMID:30575429
A condition in which gene transfer has been performed using a plasmid as the carrier of the genetic material. A plasmid is a small, circular, double-stranded DNA molecule that is distinct from a cell's chromosomal DNA. Plasmids naturally exist in bacterial cells, and they also occur in some eukaryotes. Plasmids that are used experimentally as molecular tools are called vectors.
slaulede
2021-03-04T18:11:03Z
PMID:21993171
plasmid gene transfer
experimental_condition_ontology
XCO:0000818
gene transfer using plasmid vector
XCO:0000818
A condition in which gene transfer has been performed using a plasmid as the carrier of the genetic material. A plasmid is a small, circular, double-stranded DNA molecule that is distinct from a cell's chromosomal DNA. Plasmids naturally exist in bacterial cells, and they also occur in some eukaryotes. Plasmids that are used experimentally as molecular tools are called vectors.
https://www.merriam-webster.com/
https://www.nature.com/scitable/definition/plasmid-plasmids-28/
A condition in which gene transfer has been performed using the plasmid pVAX2 as the carrier of the genetic material. The pVAX2 plasmid is based on the pVAX1 plasmid, which was designed for use in the development of DNA vaccines.
slaulede
2021-03-04T18:29:17Z
PMID:19440225
experimental_condition_ontology
XCO:0000819
gene transfer using plasmid vector pVAX2
XCO:0000819
A condition in which gene transfer has been performed using the plasmid pVAX2 as the carrier of the genetic material. The pVAX2 plasmid is based on the pVAX1 plasmid, which was designed for use in the development of DNA vaccines.
PMID:19440225
https://www.thermofisher.com/order/catalog/product/V26020#/V26020
A control condition in which gene transfer has been performed using an empty plasmid pVAX2. The pVAX2 plasmid is based on the pVAX1 plasmid, which was designed for use in the development of DNA vaccines.
slaulede
2021-03-08T13:54:50Z
PMID:19440225
PMID:21993171
gene transfer using only the backbone of plasmid vector pVAX2
experimental_condition_ontology
XCO:0000820
gene transfer using empty plasmid vector pVAX2
XCO:0000820
A control condition in which gene transfer has been performed using an empty plasmid pVAX2. The pVAX2 plasmid is based on the pVAX1 plasmid, which was designed for use in the development of DNA vaccines.
PMID:21993171
https://www.thermofisher.com/order/catalog/product/V26020#/V26020
A condition in which the rat GDNF gene has been (transiently or stably) transferred into a cell or organism using the plasmid vector pVAX2 in order to induce synthesis of that gene's product in the recipient cell or organism.
slaulede
2021-03-08T14:07:05Z
PMID:19440225
PMID:21993171
experimental_condition_ontology
XCO:0000821
gene transfer of the rat GDNF gene using the plasmid vector pVAX2
XCO:0000821
A condition in which the rat GDNF gene has been (transiently or stably) transferred into a cell or organism using the plasmid vector pVAX2 in order to induce synthesis of that gene's product in the recipient cell or organism.
PMID:21993171
https://www.thermofisher.com/order/catalog/product/V26020#/V26020
JTE-607 is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3). JTE-607 reduces the production of proinflammatory cytokines in models of acute injury, septic shock and endotoxemia.
slaulede
2021-03-09T12:06:36Z
PMID:10493164
JTE 607
JTE 607 dihydrochloride
experimental_condition_ontology
XCO:0000822
JTE-607
XCO:0000822
JTE-607 is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3). JTE-607 reduces the production of proinflammatory cytokines in models of acute injury, septic shock and endotoxemia.
https://www.sigmaaldrich.com/catalog/product/sigma/sml2833?lang=en®ion=US
https://www.tocris.com/products/jte-607-dihydrochloride_5185?gclid=Cj0KCQiA1pyCBhCtARIsAHaY_5d7izfKf8E3Lgu7fCItYrJRNFR8iSoRV7HWnsqZOjNwTGeTa9Pcu-4aAthgEALw_wcB
Any condition in which the main influencing factor is peanut oil, a colorless to yellow fatty nondrying oil that is obtained from peanuts and is used chiefly as a salad oil, in margarine, in soap, and as a vehicle in pharmaceutical preparations and cosmetics.
slaulede
2021-03-25T15:05:12Z
PMID:24388923
arachis oil
groundnut oil
experimental_condition_ontology
XCO:0000823
peanut oil
XCO:0000823
Any condition in which the main influencing factor is peanut oil, a colorless to yellow fatty nondrying oil that is obtained from peanuts and is used chiefly as a salad oil, in margarine, in soap, and as a vehicle in pharmaceutical preparations and cosmetics.
https://www.merriam-webster.com
Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is one of the most complex bacterial toxins known, composed of six subunits with an A protomer responsible for biologic activities and a B pentamer directing binding and entry of the A subunit into the cytoplasm.
slaulede
2021-04-01T16:00:00Z
PMID:1702803
B. pertussis toxin
Bordetella pertussis toxin
PT
experimental_condition_ontology
XCO:0000824
pertussis toxin
XCO:0000824
Pertussis toxin (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. PT is one of the most complex bacterial toxins known, composed of six subunits with an A protomer responsible for biologic activities and a B pentamer directing binding and entry of the A subunit into the cytoplasm.
https://en.wikipedia.org/wiki/Pertussis_toxin
https://www.sciencedirect.com/topics/medicine-and-dentistry/pertussis-toxin
An experimental condition in which the main influencing factor is cyclophosphamide (CP), an antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma.
slaulede
2021-04-01T16:35:28Z
CHEBI:4027
MESH:D003520
CP
cytophosphane
experimental_condition_ontology
XCO:0000825
cyclophosphamide
XCO:0000825
An experimental condition in which the main influencing factor is cyclophosphamide (CP), an antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma.
MESH:D003520
https://en.wikipedia.org/wiki/Cyclophosphamide
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with human myelin basic protein.
slaulede
2021-04-01T17:07:53Z
PMID:1702803
rat anti-Hu-BP T cell line
experimental_condition_ontology
XCO:0000826
rat anti-Hu-MBP T cell line
XCO:0000826
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with human myelin basic protein.
PMID:1702803
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with synthetic human myelin basic protein peptide 102-129.
slaulede
2021-04-01T17:27:28Z
PMID:1702803
experimental_condition_ontology
XCO:0000827
rat anti-Hu-S102-129 T cell line
XCO:0000827
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with synthetic human myelin basic protein peptide 102-129.
PMID:1702803
Any condition in which the main influencing factor is human myelin basic protein, a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon. Human myelin basic protein is purified from human tissue or extracted from cultured cells containing cloned copies of the human myelin basic protein gene.
slaulede
2021-04-01T17:46:52Z
PMID:1702803
Hu-BP
human MBP
experimental_condition_ontology
XCO:0000828
human myelin basic protein
XCO:0000828
Any condition in which the main influencing factor is human myelin basic protein, a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon. Human myelin basic protein is purified from human tissue or extracted from cultured cells containing cloned copies of the human myelin basic protein gene.
PMID:1702803
Corn oil is a refined fixed, that is, nonvolatile, oil obtained from from the germ of corn kernels. It has high polyunsaturated lipid content and is used as a delivery vehicle for lipophilic substances.
slaulede
2021-04-08T17:10:21Z
PMID:26514922
maize oil
experimental_condition_ontology
XCO:0000829
corn oil
XCO:0000829
Corn oil is a refined fixed, that is, nonvolatile, oil obtained from from the germ of corn kernels. It has high polyunsaturated lipid content and is used as a delivery vehicle for lipophilic substances.
ISBN-13:978-1608316922
https://www.merriam-webster.com
Any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF), a buffer solution prepared with a composition representative of cerebrospinal fluid. It is used experimentally for rat brain microdialysis experiments, the culture of hippocampal tissue slices, or irrigation treatment of brain trauma lesions to supply oxygen, maintain osmolarity, and to buffer pH at biological levels.
slaulede
2021-04-23T17:15:50Z
PMID:22356885
aCSF
cerebrospinal fluid simulation fluid
experimental_condition_ontology
XCO:0000830
artificial cerebrospinal fluid
XCO:0000830
Any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF), a buffer solution prepared with a composition representative of cerebrospinal fluid. It is used experimentally for rat brain microdialysis experiments, the culture of hippocampal tissue slices, or irrigation treatment of brain trauma lesions to supply oxygen, maintain osmolarity, and to buffer pH at biological levels.
https://biochemazone.com/product/artificial-cerebrospinal-solution-bz178/
https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid
Any condition in which the main influencing factor is a 2% solution (v/v) of dimethyl sulfoxide in artificial cerebrospinal fluid, a buffer solution prepared with a composition representative of cerebrospinal fluid. Dimethyl sulfoxide is a 2-carbon sulfoxide and highly polar organic liquid, that is used widely as a chemical solvent.
slaulede
2021-04-23T17:27:15Z
PMID:22356885
2% DMSO in aCSF
experimental_condition_ontology
XCO:0000831
2% dimethyl sulfoxide in artificial cerebrospinal fluid
XCO:0000831
Any condition in which the main influencing factor is a 2% solution (v/v) of dimethyl sulfoxide in artificial cerebrospinal fluid, a buffer solution prepared with a composition representative of cerebrospinal fluid. Dimethyl sulfoxide is a 2-carbon sulfoxide and highly polar organic liquid, that is used widely as a chemical solvent.
CHEBI:28262
MESH:D004121
https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid
Any process involving manual and instrumental techniques for incision of a lens in the eye of an organism to investigate and/or treat a pathological condition.
slaulede
2021-04-30T17:36:25Z
intentional incision of an ocular lens
experimental_condition_ontology
XCO:0000832
lensotomy
XCO:0000832
Any process involving manual and instrumental techniques for incision of a lens in the eye of an organism to investigate and/or treat a pathological condition.
PMID:16631043
https://en.wikipedia.org/wiki/List_of_surgical_procedures
Any condition in which the main influencing factor is lacidipine, a lipophilic dihydropyridine calcium channel blocker with a slow onset of action used to treat hypertension.
slaulede
2021-05-10T13:22:23Z
CHEBI:135737
MESH:C060285
PMID:10023637
Lacipil
Motens
experimental_condition_ontology
XCO:0000833
lacidipine
XCO:0000833
Any condition in which the main influencing factor is lacidipine, a lipophilic dihydropyridine calcium channel blocker with a slow onset of action used to treat hypertension.
https://go.drugbank.com/drugs/DB09236
https://www.sigmaaldrich.com/catalog/product/sigma/sml0946?lang=en®ion=US&utm_medium=cpc&utm_source=bing&utm_term=lacidipine&utm_campaign=Backlog%20Product-Focused%20Ads%20Phase%202%20(Bing%20ebizpfs)%20(new_c)&utm_content=sigma/sml0946
Any condition in which the main influencing factor is formaldehyde, an aldehyde resulting from the formal oxidation of methanol. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative.
slaulede
2021-05-17T14:00:31Z
CHEBI:16842
PMID:21184763
Methanal
Methylene oxide
Oxomethane
formalin
experimental_condition_ontology
XCO:0000834
formaldehyde
XCO:0000834
Any condition in which the main influencing factor is formaldehyde, an aldehyde resulting from the formal oxidation of methanol. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative.
CHEBI:16842
MESH:D005557
A condition in which the main influencing factor is a rat malignant glioma cell line.
slaulede
2021-05-18T13:29:46Z
CVCL_5712
PMID:23079672
BT4c
experimental_condition_ontology
XCO:0000835
BT4C cells
XCO:0000835
A condition in which the main influencing factor is a rat malignant glioma cell line.
PMID:23079672
https://web.expasy.org/cellosaurus/CVCL_5712
A condition in which the herpes simplex virus thymidine kinase (HSV-tk) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
slaulede
2021-05-18T13:40:36Z
PMID:23079672
gene transfer of the Herpes Simplex Virus type 1 thymidine kinase gene using an adenovirus vector
gene transfer of the herpes simplex virus thymidine kinase gene using an adenovirus vector
gene transfer using AdHSV-tk
experimental_condition_ontology
XCO:0000836
gene transfer of the HSV-tk gene using an adenovirus vector
XCO:0000836
A condition in which the herpes simplex virus thymidine kinase (HSV-tk) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
PMID:23079672
A condition in which the 15-Lipoxygenase-1 (15-LO-1) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
slaulede
2021-05-18T13:57:02Z
PMID:23079672
gene transfer of the 15-Lipoxygenase-1 gene using an adenovirus vector
gene transfer using Ad15-LO-1
experimental_condition_ontology
XCO:0000837
gene transfer of the 15-LO-1 gene using an adenovirus vector
XCO:0000837
A condition in which the 15-Lipoxygenase-1 (15-LO-1) gene has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
PMID:23079672
Any condition in which the main influencing factor is an agent that blocks the mineralocorticoid (primarily aldosterone) receptor (NR3C2), which regulates water and electrolyte metabolism.
slaulede
2021-05-21T11:58:21Z
PMID:32088716
MR antagonist
aldosterone receptor antagonist
experimental_condition_ontology
XCO:0000838
mineralocorticoid receptor antagonist
XCO:0000838
Any condition in which the main influencing factor is an agent that blocks the mineralocorticoid (primarily aldosterone) receptor (NR3C2), which regulates water and electrolyte metabolism.
https://en.wikipedia.org/wiki/Aldosterone
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mineralocorticoids
Any condition in which the main influencing factor is finerenone, a nonsteroidal mineralocorticoid receptor antagonist.
slaulede
2021-05-21T12:40:05Z
PMID:32088716
BAY 94-8862
DB16165
FIN
experimental_condition_ontology
XCO:0000839
finerenone
XCO:0000839
Any condition in which the main influencing factor is finerenone, a nonsteroidal mineralocorticoid receptor antagonist.
https://en.wikipedia.org/wiki/Finerenone
https://www.medchemexpress.com/finerenone.html
Any condition in which the main influencing factor is Eplerenone, a steroidal antimineralocorticoid of the spirolactone group and a selective aldosterone receptor antagonist (SARA).
slaulede
2021-05-21T12:50:59Z
PMID:32088716
DB00700
Inspra
epoxymexrenone
experimental_condition_ontology
XCO:0000840
Eplerenone
XCO:0000840
Any condition in which the main influencing factor is Eplerenone, a steroidal antimineralocorticoid of the spirolactone group and a selective aldosterone receptor antagonist (SARA).
https://en.wikipedia.org/wiki/Eplerenone
https://go.drugbank.com/drugs/DB00700
An experimental condition in which the main influencing factor is GSK-812, a potent neuroprotectant that can induce GDNF in normal and diseased retina, and antagonizes multiple receptors, including D2 and D3 receptors, and 5-HT2A, 2C, and 5-HT6 receptors..
slaulede
2021-06-04T12:00:41Z
PMID:28441076
1H-3-Benzazepine, 7-[[4-[(4-chlorophenyl)Methoxy]phenyl]sulfonyl]-2,3,4,5-tetrahydro-8-Methoxy-3-Methyl-
7-[4-[(4-chlorophenyl)methoxy]phenyl]sulfonyl-8-methoxy-3-methyl-1,2,4,5-tetrahydro-3-benzazepine
7-[[4-[(4-Chlorophenyl)methoxy]phenyl]sulfonyl]-2,3,4,5-tetrahydro-8-methoxy-3-methyl-1H-3-benzazepine
GSK812
experimental_condition_ontology
XCO:0000841
GSK-812
XCO:0000841
An experimental condition in which the main influencing factor is GSK-812, a potent neuroprotectant that can induce GDNF in normal and diseased retina, and antagonizes multiple receptors, including D2 and D3 receptors, and 5-HT2A, 2C, and 5-HT6 receptors..
PMID:28441076
http://www.probechem.com/products_GSK-812.aspx
Any condition in which the main influencing factor is a nicotinic antagonist, a type of anticholinergic drug that inhibits the action of acetylcholine (ACh) at nicotinic acetylcholine receptors.
slaulede
2021-06-10T10:31:44Z
CHEBI:48878
PMID:24400148
nicotinic acetylcholine receptor antagonist
nicotinic cholinergic antagonist
experimental_condition_ontology
XCO:0000842
nicotinic antagonist
XCO:0000842
Any condition in which the main influencing factor is a nicotinic antagonist, a type of anticholinergic drug that inhibits the action of acetylcholine (ACh) at nicotinic acetylcholine receptors.
CHEBI:48878
https://en.wikipedia.org/wiki/Nicotinic_antagonist
Any condition in which the main influencing factor is mecamylamine, a ganglionic blocking agent that inhibits transmission between preganglionic and postganglionic neurons in the autonomic nervous system.
slaulede
2021-06-10T11:03:37Z
PMID:24400148
C11H21N
Inversine
Vecamyl
experimental_condition_ontology
XCO:0000843
mecamylamine
XCO:0000843
Any condition in which the main influencing factor is mecamylamine, a ganglionic blocking agent that inhibits transmission between preganglionic and postganglionic neurons in the autonomic nervous system.
CHEBI:48878
MESH:D008464
https://en.wikipedia.org/wiki/Mecamylamine
This is any condition in which the main influencing factor is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups). Sodium phenobarbital is an acvtivator of the constitutive androstane receptor (CAR; Nr1i3).
slaulede
2021-06-24T15:00:49Z
PMID:29548889
C12H11N2NaO3
Luminal sodium
NaPB
Sodium phenobarbitone
phenobarbital sodium
phenobarbital sodium salt
experimental_condition_ontology
XCO:0000844
sodium phenobarbital
XCO:0000844
This is any condition in which the main influencing factor is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups). Sodium phenobarbital is an acvtivator of the constitutive androstane receptor (CAR; Nr1i3).
CHEBI:8070
PMID:29548889
Any condition in which the main influencing factor is pregnenolone 16alpha-carbonitrile, a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR; Nr1i2).
slaulede
2021-06-24T15:21:50Z
MESH:D011285
PMID:29548889
3beta-hydroxy-20-oxopregn-5-ene-16alpha-carbonitrile
C22H31NO2
PCN
experimental_condition_ontology
XCO:0000845
pregnenolone 16alpha-carbonitrile
XCO:0000845
Any condition in which the main influencing factor is pregnenolone 16alpha-carbonitrile, a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR; Nr1i2).
CHEBI:35591
PMID:5793358
Any condition in which the main influencing factor is a 28 amino acid polypeptide representing residues 102 to 129 in the human myelin basic protein molecule. Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon.
slaulede
2021-06-28T15:35:55Z
PMID:1702803
PSQGKGRGLSLSRFSWGAEGQRPGFGYG
experimental_condition_ontology
XCO:0000846
Hu-S102-129
XCO:0000846
Any condition in which the main influencing factor is a 28 amino acid polypeptide representing residues 102 to 129 in the human myelin basic protein molecule. Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon.
PMID:1702803
Any condition in which the main influencing factor is a 20 amino acid polypeptide representing residues 110 to 129 in the human myelin basic protein molecule. Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon.
slaulede
2021-06-28T15:42:51Z
PMID:1702803
LSLSRFSWGAEGQRPGFGYG
experimental_condition_ontology
XCO:0000847
Hu-S110-129
XCO:0000847
Any condition in which the main influencing factor is a 20 amino acid polypeptide representing residues 110 to 129 in the human myelin basic protein molecule. Myelin basic protein is a hydrophobic insulator that can be synthesized by the oligodendrocyte and/or Schwann cell as part of the myelin sheath which is wrapped around the axon.
PMID:1702803
An experimental condition in which the main influencing factor is negatively charged liposomes containing doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication.
slaulede
2021-06-28T17:06:42Z
PMID:6744286
lip- DXR
experimental_condition_ontology
XCO:0000848
negatively charged liposome-entrapped doxorubicin
XCO:0000848
An experimental condition in which the main influencing factor is negatively charged liposomes containing doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication.
PMID:6744286
An experimental condition in which the main influencing factor is positively charged liposomes containing doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication.
slaulede
2021-06-28T17:14:08Z
PMID:6744286
lip+ DXR
experimental_condition_ontology
XCO:0000849
positively charged liposome-entrapped doxorubicin
XCO:0000849
An experimental condition in which the main influencing factor is positively charged liposomes containing doxorubicin, a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius and used as a chemotherapy medication.
PMID:6744286
This is a condition in which the main influencing factor is a chemical, biologic, or organism that exerts some force or effect resulting in a favorable outcome or improvement in the symptoms of a disorder or disease.
slaulede
2021-06-28T18:20:14Z
PMID:29273085
medicinal agent
remedial agent
experimental_condition_ontology
Not4Curation
XCO:0000850
therapeutic agent
XCO:0000850
This is a condition in which the main influencing factor is a chemical, biologic, or organism that exerts some force or effect resulting in a favorable outcome or improvement in the symptoms of a disorder or disease.
ISBN-13:978-0683400076
https://www.merriam-webster.com/
This is a condition in which the main influencing factor is a stem cell, an unspecialized cell capable of perpetuating itself through cell division and having the potential to give rise to a variety of differentiated cells with specialized functions.
slaulede
2021-06-28T18:41:49Z
PMID:29273085
experimental_condition_ontology
Not4Curation
XCO:0000851
stem cells
XCO:0000851
This is a condition in which the main influencing factor is a stem cell, an unspecialized cell capable of perpetuating itself through cell division and having the potential to give rise to a variety of differentiated cells with specialized functions.
CL:0000034
https://en.wikipedia.org/wiki/Stem_cell
https://www.merriam-webster.com/
A condition in which the main influencing factor is human periodontal ligament-derived stem cells, which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal and other tissue type regeneration. The advantages of the use of dental stem cells include their easy isolation by noninvasive routine clinical procedures, their broad differentiation potential, minimal ethical concerns, and that they may enable autologous transplantation.
slaulede
2021-06-29T11:11:08Z
PMID:29273085
hPDLSCs
experimental_condition_ontology
XCO:0000852
human periodontal ligament-derived stem cells
XCO:0000852
A condition in which the main influencing factor is human periodontal ligament-derived stem cells, which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal and other tissue type regeneration. The advantages of the use of dental stem cells include their easy isolation by noninvasive routine clinical procedures, their broad differentiation potential, minimal ethical concerns, and that they may enable autologous transplantation.
PMID:25861283
PMID:29273085
Any condition in which the main influencing factor is serum prepared from rats bearing a subcutaneously injected B48-14 IgE-producing hybridoma. The serum is essentially antiserum containing B48-14 IgE, which are directed against a S. mansoni adult worm antigen.
slaulede
2021-06-29T17:41:28Z
PMID:3108390
experimental_condition_ontology
XCO:0000853
rat serum from subject bearing a B48-14 IgE-producing hybridoma
XCO:0000853
Any condition in which the main influencing factor is serum prepared from rats bearing a subcutaneously injected B48-14 IgE-producing hybridoma. The serum is essentially antiserum containing B48-14 IgE, which are directed against a S. mansoni adult worm antigen.
PMID:3108390
https://www.merriam-webster.com/
Any condition in which the main influencing factor is serum prepared from rats bearing subcutaneously injected IR983F myeloma cells. The serum is essentially control for antiserum from rats bearing IgE-producing hybridomas.
slaulede
2021-06-29T18:07:47Z
PMID:3108390
rat serum from subject bearing IR 983 F myeloma
experimental_condition_ontology
XCO:0000854
rat serum from subject bearing IR983F myeloma
XCO:0000854
Any condition in which the main influencing factor is serum prepared from rats bearing subcutaneously injected IR983F myeloma cells. The serum is essentially control for antiserum from rats bearing IgE-producing hybridomas.
PMID:3108390
https://www.merriam-webster.com/
Any condition in which the main influencing factor is serum prepared from rats bearing a subcutaneously injected non-specified IgE-producing hybridoma. The serum is essentially antiserum containing control IgE, which are directed against an unspecified antigen.
slaulede
2021-06-29T18:12:26Z
PMID:3108390
experimental_condition_ontology
XCO:0000855
rat serum from subject bearing a non-specified IgE-producing hybridoma
XCO:0000855
Any condition in which the main influencing factor is serum prepared from rats bearing a subcutaneously injected non-specified IgE-producing hybridoma. The serum is essentially antiserum containing control IgE, which are directed against an unspecified antigen.
PMID:3108390
https://www.merriam-webster.com/
A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups. It is produced by various plants and has anti-oxidant, anti-inflammatory, cardioprotective, anti-mutagenic, and anti-carcinogenic properties.
slaulede
2021-06-29T18:22:55Z
PMID:30621358
3,4',5-Stilbenetriol
3,4',5-Trihydroxystilbene
5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
RSV
SRT501
experimental_condition_ontology
XCO:0000856
resveratrol
XCO:0000856
A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups. It is produced by various plants and has anti-oxidant, anti-inflammatory, cardioprotective, anti-mutagenic, and anti-carcinogenic properties.
MESH:D000077185
Any condition in which the main influencing factor is vildagliptin, a pyrrolidine-carbonitrile derivative and potent inhibitor of dipeptidyl peptidase 4 (DPP-4) that is used in the treatment of type 2 diabetes mellitus.
slaulede
2021-07-02T13:08:02Z
PMID:23774700
VG
experimental_condition_ontology
XCO:0000857
vildagliptin
XCO:0000857
Any condition in which the main influencing factor is vildagliptin, a pyrrolidine-carbonitrile derivative and potent inhibitor of dipeptidyl peptidase 4 (DPP-4) that is used in the treatment of type 2 diabetes mellitus.
MESH:D000077597
PMID:23774700
Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against non-specific IgE antibodies.
slaulede
2021-07-02T17:20:09Z
PMID:1719096
PMID:2494262
experimental_condition_ontology
XCO:0000858
rat anti-control-Ab2 T cells
XCO:0000858
Any condition in which the main influencing factor is an injection of T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against non-specific IgE antibodies.
PMID:1719096
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against non-specific IgE antibodies.
slaulede
2021-07-02T17:23:47Z
PMID:1719096
PMID:2494262
experimental_condition_ontology
XCO:0000859
rat anti-control-Ab2 T cell line
XCO:0000859
Any condition in which the main influencing factor is an injection of cultured cells derived from T cells prepared from the lymph nodes of rats immunized with Ab2 antibodies. These Ab2 antibodies are antiidiotypic antibodies raised against non-specific IgE antibodies.
PMID:1719096
A condition in which the main influencing factor is a monoclonal antibody having specific amino acid sequences with the ability to adhere to and interact specifically with recombinant human vascular endothelial growth factor 165.
slaulede
2021-07-06T14:53:33Z
PMID:15702434
anti-recombinant human vascular endothelial growth factor 165 monoclonal antibody
experimental_condition_ontology
XCO:0000860
anti-rh-VEGF165 monoclonal antibody
XCO:0000860
A condition in which the main influencing factor is a monoclonal antibody having specific amino acid sequences with the ability to adhere to and interact specifically with recombinant human vascular endothelial growth factor 165.
PMID:11316858
https://www.merriam-webster.com/
A condition in which the main influencing factor is an isotype-matched (IgG) monoclonal antibody to provide a control for some target-specific monoclonal antibody.
slaulede
2021-07-06T15:18:46Z
PMID:15702434
isotype-matched control Ab
experimental_condition_ontology
XCO:0000861
control IgG monoclonal antibody
XCO:0000861
A condition in which the main influencing factor is an isotype-matched (IgG) monoclonal antibody to provide a control for some target-specific monoclonal antibody.
PMID:11316858
https://www.merriam-webster.com/
A condition in which the main influencing factor is bendroflumethiazide, a sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders.
slaulede
2021-07-06T17:28:01Z
PMID:18480177
Aprinox
BTZ
bendrofluazide
experimental_condition_ontology
XCO:0000862
bendroflumethiazide
XCO:0000862
A condition in which the main influencing factor is bendroflumethiazide, a sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders.
CHEBI:3013
MESH:D001539
This is any condition in which the main influencing factor is a drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
slaulede
2021-07-06T17:35:52Z
PMID:18480177
antihypertensive drug
experimental_condition_ontology
XCO:0000863
antihypertensive agent
XCO:0000863
This is any condition in which the main influencing factor is a drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
CHEBI:35674
ISBN-13:9780781733908
A condition involving surgical manipulation causing blockage of one or more branches of the hepatic portal vein, a vein that transports nutrients from the digestive tract to the liver.
slaulede
2021-07-08T13:48:54Z
PMID:32156510
HPV occlusion
liver portal vein occlusion
experimental_condition_ontology
hepatic portal vein ligation
XCO:0000864
hepatic portal vein occlusion
XCO:0000864
A condition involving surgical manipulation causing blockage of one or more branches of the hepatic portal vein, a vein that transports nutrients from the digestive tract to the liver.
ISBN-13:9780781733908
PMID:32156510
A condition in which the main influencing factor is an androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary.
slaulede
2021-07-09T13:35:10Z
PMID:9415976
DHEA
androstenolone
experimental_condition_ontology
XCO:0000865
dehydroepiandrosterone
XCO:0000865
A condition in which the main influencing factor is an androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary.
CHEBI:28689
MESH:D003687
Any process involving manual and instrumental techniques for incision of the internal anal sphincter muscle. The inner is controlled by the nervous system, while the external anal sphincter muscle is under voluntary control.
slaulede
2021-07-09T16:04:48Z
PMID:29391927
lateral internal sphincterotomy
sphincterotomy
experimental_condition_ontology
XCO:0000866
anal sphincter myotomy
XCO:0000866
Any process involving manual and instrumental techniques for incision of the internal anal sphincter muscle. The inner is controlled by the nervous system, while the external anal sphincter muscle is under voluntary control.
https://www.merriam-webster.com/medical/myotomy
https://www.verywellhealth.com/sphincterotomy-overview-4584862
A process in which manual and instrumental techniques are used to close a wound or surgical incision with sutures, staples, glue, or some other closure material.
slaulede
2021-07-09T16:46:51Z
PMID:29391927
incision closure
incision stapling
incision suturing
experimental_condition_ontology
XCO:0000867
incision repair
XCO:0000867
A process in which manual and instrumental techniques are used to close a wound or surgical incision with sutures, staples, glue, or some other closure material.
ISBN-13:9780781733908
https://www.merriam-webster.com/
A process in which manual and instrumental techniques are used to close a wound or surgical incision with sutures. Surgical sutures are specially made thread that comes in different sizes and different material.
slaulede
2021-07-09T17:22:07Z
PMID:29391927
incision suturing
experimental_condition_ontology
XCO:0000868
incision repair with conventional suture
XCO:0000868
A process in which manual and instrumental techniques are used to close a wound or surgical incision with sutures. Surgical sutures are specially made thread that comes in different sizes and different material.
ISBN-13:9780781733908
https://www.merriam-webster.com/
A process in which manual and instrumental techniques are used to close a wound or surgical incision with biosutures. Biosutures are surgical sutures upon which stem cells have been grown in vitro.
slaulede
2021-07-12T10:20:45Z
PMID:18690635
PMID:29391927
incision suturing with biosuture
experimental_condition_ontology
XCO:0000869
incision repair with biosuture
XCO:0000869
A process in which manual and instrumental techniques are used to close a wound or surgical incision with biosutures. Biosutures are surgical sutures upon which stem cells have been grown in vitro.
PMID:29391927
https://www.merriam-webster.com/
A condition in which the main influencing factor is a rat stem cell, isolated from subcutaneous fat tissue and cultured in vitro. A stem cell is an unspecialized cell capable of perpetuating itself through cell division and having the potential to give rise to a variety of differentiated cells with specialized functions.
slaulede
2021-07-12T12:42:34Z
adipose-derived stem cells
PMID:29391927
experimental_condition_ontology
XCO:0000870
rat adipose-derived stem cells
XCO:0000870
A condition in which the main influencing factor is a rat stem cell, isolated from subcutaneous fat tissue and cultured in vitro. A stem cell is an unspecialized cell capable of perpetuating itself through cell division and having the potential to give rise to a variety of differentiated cells with specialized functions.
PMID:29391927
https://www.merriam-webster.com/
A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. Following conversion to the active deoxynucleotide, It inhibits DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
slaulede
2021-07-16T15:49:31Z
PMID:10431686
5-FU
5-Fluoracil
5-fluoropyrimidine-2,4(1H,3H)-dione
fluorouracil
experimental_condition_ontology
XCO:0000871
5-fluorouracil
XCO:0000871
A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. Following conversion to the active deoxynucleotide, It inhibits DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
CHEBI:46345
MESH:D005472
This is any condition in which the main influencing factor is thymosin alpha-1, a member of a family of heat-stable, polypeptide hormones secreted by the thymus gland. Thymosins are immune response-modulating molecules.
slaulede
2021-07-16T16:55:07Z
PMID:10431686
thymalfasin
experimental_condition_ontology
PTMA
TMSA
prothymosin alpha
prothymosin, alpha
XCO:0000872
thymosin alpha-1
XCO:0000872
This is any condition in which the main influencing factor is thymosin alpha-1, a member of a family of heat-stable, polypeptide hormones secreted by the thymus gland. Thymosins are immune response-modulating molecules.
MESH:D013947
PMID:33362999
A condition in which the main influencing factor is the pulmonary metastatic subclone Sp-5 of a rat colonic carcinoma cell line (DHD/K12/TRb) used to study biochemical correlates of metastasis.
slaulede
2021-07-19T17:18:00Z
PMID:7818325
DHD K12/TRb - Sp-5 cells
DHD-K12 TRb - Sp-5 cells
DHD/K12 - Sp-5 cells
TRb - Sp-5 cells
experimental_condition_ontology
XCO:0000873
DHD/K12/TRb - Sp-5 cells
XCO:0000873
A condition in which the main influencing factor is the pulmonary metastatic subclone Sp-5 of a rat colonic carcinoma cell line (DHD/K12/TRb) used to study biochemical correlates of metastasis.
PMID:19850492
PMID:7818325
Any experimental condition in which the internal or external environment of one or both lungs is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body.
slaulede
2021-07-19T17:25:18Z
PMID:7818325
Not4Curation
controlled in situ pulmonary condition
experimental_condition_ontology
XCO:0000874
controlled in situ lung condition
XCO:0000874
Any experimental condition in which the internal or external environment of one or both lungs is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body.
ISBN-13:9780781733908
https://www.merriam-webster.com/
An experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle.
slaulede
2021-07-19T17:33:20Z
PMID:7818325
isolated single lung perfusion
experimental_condition_ontology
XCO:0000875
isolated lung perfusion
XCO:0000875
An experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle.
PMID:7818325
PMID:8347000
This is an antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
slaulede
2021-07-19T18:12:49Z
2'-deoxy-5-fluorouridine
5-FUdR
5-Fluorodeoxyuridine
5FDU
FUDR
PMID:7818325
deoxyfluorouridine
fluorodeoxyuridine
experimental_condition_ontology
XCO:0000876
floxuridine
XCO:0000876
This is an antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
CHEBI:60761
MESH:D005467
Any condition in which the main influencing factor is Hespan buffer, 6% hetastarch in buffered solution. A buffer is a homogeneous mixture of molecules, atoms and/or ions, one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed in a sufficient quantity of solvent.
slaulede
2021-07-19T18:38:39Z
PMID:7818325
HB
experimental_condition_ontology
XCO:0000877
Hespan buffer
XCO:0000877
Any condition in which the main influencing factor is Hespan buffer, 6% hetastarch in buffered solution. A buffer is a homogeneous mixture of molecules, atoms and/or ions, one or more of which have the capacity to cause the solution to resist change in pH upon addition of small amounts of acid or base, dispersed in a sufficient quantity of solvent.
PMID:10155362
https://www.fda.gov
Any condition in which the main influencing factor is Hespan buffer (6% hetastarch in buffered solution) injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
slaulede
2021-07-20T13:59:06Z
PMID:7818325
HB perfusate
experimental_condition_ontology
XCO:0000878
Hespan buffer perfusate
XCO:0000878
Any condition in which the main influencing factor is Hespan buffer (6% hetastarch in buffered solution) injected or pumped into, or poured through, an organ or tissue, usually via a blood vessel.
PMID:10155362
https://www.fda.gov
A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. It is an anti-inflammatory agent used topically in the treatment of various skin disorders.
slaulede
2021-07-20T14:16:29Z
PMID:27856527
Azmacort
Cinonide
Kenalog 40
Tricort-40
experimental_condition_ontology
XCO:0000879
triamcinolone acetonide
XCO:0000879
A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. It is an anti-inflammatory agent used topically in the treatment of various skin disorders.
CHEBI:71418
MESH:D014222
Any condition in which the main influencing factor is mifepristone, a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary Cushing Syndrome.
slaulede
2021-07-20T14:26:43Z
PMID:27856527
Mifegyne
Mifeprex
RU 38486
RU-486
RU38486
RU486
ZK98296
experimental_condition_ontology
XCO:0000880
mifepristone
XCO:0000880
Any condition in which the main influencing factor is mifepristone, a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary Cushing Syndrome.
MESH:D015735
This is 4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine readily crosses the blood-brain barrier, and has been used to measure total and regional cerebral blood flow in vivo.
slaulede
2021-07-29T17:59:13Z
PMID:29498562
pubchem.compound:101126542
4-Iodoantipyrene-N-methyl-14C
4-iodo-5-methyl-1-(114C)methyl-2-phenylpyrazol-3-one
C11H11IN2O
experimental_condition_ontology
XCO:0000881
4[N-methyl-14C] iodoantipyrine
XCO:0000881
This is 4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine readily crosses the blood-brain barrier, and has been used to measure total and regional cerebral blood flow in vivo.
https://www.perkinelmer.com/product/iodoantipyrine-4-n-methyl-14c-nec712050uc#
This procedure involves removal of about 80% of the stomach, leaving a tube-shaped stomach about the size and shape of a banana. The procedure is typically performed as a surgical intervention for weight control.
slaulede
2021-08-02T15:06:01Z
PMID:29168078
vertical sleeve gastrectomy
experimental_condition_ontology
XCO:0000882
sleeve gastrectomy
XCO:0000882
This procedure involves removal of about 80% of the stomach, leaving a tube-shaped stomach about the size and shape of a banana. The procedure is typically performed as a surgical intervention for weight control.
ISBN-13:9780781733908
https://www.mayoclinic.org/tests-procedures/sleeve-gastrectomy/about/pac-20385183
This is a substituted benzimidazole and proton pump inhibitor that is used in the treatment of gastroesophageal reflux and peptic ulcer.
slaulede
2021-08-02T15:19:16Z
PMID:29168078
5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
BY-1023
Protonix
SKF-96022
experimental_condition_ontology
XCO:0000883
pantoprazole
XCO:0000883
This is a substituted benzimidazole and proton pump inhibitor that is used in the treatment of gastroesophageal reflux and peptic ulcer.
CHEBI:7915
MESH:D000077402
Any condition in which the main influencing factor is trypan blue, an azo dye used as a vital stain to selectively colour dead tissues or cells blue.
slaulede
2021-08-02T16:18:02Z
PMID:3347907
tetrasodium 3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonate)
experimental_condition_ontology
XCO:0000884
trypan blue
XCO:0000884
Any condition in which the main influencing factor is trypan blue, an azo dye used as a vital stain to selectively colour dead tissues or cells blue.
https://en.wikipedia.org/wiki/Trypan_blue
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/trypan-blue
A condition in which the main influencing factor is substance that is toxic to the pancreatic insulin-producing beta cells of the islets of Langerhans in rodents and other animals and can therefore be used for modeling diabetes mellitus through destruction of the beta cells.
slaulede
2021-08-09T17:47:11Z
PMID:12401717
experimental_condition_ontology
XCO:0000885
diabetes-inducing chemical
XCO:0000885
A condition in which the main influencing factor is substance that is toxic to the pancreatic insulin-producing beta cells of the islets of Langerhans in rodents and other animals and can therefore be used for modeling diabetes mellitus through destruction of the beta cells.
CHEBI:9288
ISBN-13:9780781733908
A condition in which the main influencing factor is substance that causes seizures in experimental animals, initiated by the injection of a drug.
slaulede
2021-08-09T18:13:25Z
PMID:31039378
seizure-inducing chemical
experimental_condition_ontology
XCO:0000886
epilepsy-inducing chemical
XCO:0000886
A condition in which the main influencing factor is substance that causes seizures in experimental animals, initiated by the injection of a drug.
DOID:9007090
PMID:31039378
This a pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive gamma-aminobutyric acid antagonist. Pentetrazol has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
slaulede
2021-08-10T12:49:31Z
CHEBI:34910
PMID:31039378
1,5-pentamethylenetetrazole
PTZ
pentamethylenetetrazole
pentylenetetrazole
experimental_condition_ontology
XCO:0000887
pentetrazol
XCO:0000887
This a pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive gamma-aminobutyric acid antagonist. Pentetrazol has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
MESH:D010433
Pilocarpine is a miotic alkaloid obtained from jaborandi that is used chiefly in the form of its hydrochloride or nitrate especially in the treatment of glaucoma. It is a cholinergic (muscarinic) agonist and used to cause seizures in animal models of epilepsy.
slaulede
2021-08-10T13:18:44Z
CHEBI:39462
PMID:31039378
experimental_condition_ontology
XCO:0000888
pilocarpine
XCO:0000888
Pilocarpine is a miotic alkaloid obtained from jaborandi that is used chiefly in the form of its hydrochloride or nitrate especially in the treatment of glaucoma. It is a cholinergic (muscarinic) agonist and used to cause seizures in animal models of epilepsy.
MESH:D010862
https://medlineplus.gov/druginfo/meds/a608039.html
https://www.merriam-webster.com/
Ionomycin is a very long-chain fatty acid that is a calcium ionophore produced by Streptomyces conglobatus. It is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.
slaulede
2021-08-10T13:36:53Z
CHEBI:63954
MESH:D015759
PMID:32300198
C41H72O9
experimental_condition_ontology
XCO:0000889
ionomycin
XCO:0000889
Ionomycin is a very long-chain fatty acid that is a calcium ionophore produced by Streptomyces conglobatus. It is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.
CHEBI:63954
MESH:D015759
A compound that facilitates transmission of an ion across a lipid barrier (as in a cell membrane) by combining with the ion or by increasing the permeability of the barrier to it.
slaulede
2021-08-10T13:40:47Z
PMID:32300198
ion carrier
experimental_condition_ontology
XCO:0000890
ionophore
XCO:0000890
A compound that facilitates transmission of an ion across a lipid barrier (as in a cell membrane) by combining with the ion or by increasing the permeability of the barrier to it.
CHEBI:24869
https://www.merriam-webster.com/
Phorbol 13-acetate 12-myristate is a phorbol ester found in croton oil with very effective tumor promoting activity. It is a protein kinase C agonist and stimulates the synthesis of both DNA and RNA.
slaulede
2021-08-10T13:54:49Z
CHEBI:37537
12-O-Tetradecanoyl Phorbol 13-Acetate
PMA
TPA
phorbol myristate acetate
tetradecanoylphorbol acetate
experimental_condition_ontology
XCO:0000891
phorbol 13-acetate 12-myristate
XCO:0000891
Phorbol 13-acetate 12-myristate is a phorbol ester found in croton oil with very effective tumor promoting activity. It is a protein kinase C agonist and stimulates the synthesis of both DNA and RNA.
MESH:D013755
Tumor promoters are substances that enhance tumorigenicity when administered after a carcinogen. In general, tumor promoters do not possess tumorigenic activity themselves.
slaulede
2021-08-10T15:45:15Z
PMID:32300198
experimental_condition_ontology
XCO:0000892
tumor promoter
XCO:0000892
Tumor promoters are substances that enhance tumorigenicity when administered after a carcinogen. In general, tumor promoters do not possess tumorigenic activity themselves.
PMID:10417370
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/tumor-promotion
A drink made up of water and a specified amount of ramipril in which the amount of ramipril consumed is maintained at a specified level.
slaulede
2021-08-26T11:53:55Z
CHEBI:8774
PMID:20864942
controlled Altace content drinking water
experimental_condition_ontology
XCO:0000893
controlled ramipril content drinking water
XCO:0000893
A drink made up of water and a specified amount of ramipril in which the amount of ramipril consumed is maintained at a specified level.
PMID:20864942
https://www.merriam-webster.com/
A regimen of solid food in which the amount of hesperidin, a disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage, is controlled.
slaulede
2021-08-27T15:37:24Z
CHEBI:28775
MESH:D006569
PMID:19966469
controlled Hesperetin 7-O-Rutinoside content diet
controlled Hesperidin 2S content diet
experimental_condition_ontology
XCO:0000894
controlled hesperidin content diet
XCO:0000894
A regimen of solid food in which the amount of hesperidin, a disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage, is controlled.
CHEBI:28775
A regimen of solid food in which the amount of cyclodextrin (CD)-clathrated hesperetin is controlled. CD-clathrated hesperetin is the aglycone of hesperidin. Clathration by CD enhances hesperetin solubility.
slaulede
2021-08-27T15:46:09Z
CHEBI:28230
MESH:C013015
PMID:19966469
experimental_condition_ontology
XCO:0000895
controlled cyclodextrin (CD)-clathrated hesperetin content diet
XCO:0000895
A regimen of solid food in which the amount of cyclodextrin (CD)-clathrated hesperetin is controlled. CD-clathrated hesperetin is the aglycone of hesperidin. Clathration by CD enhances hesperetin solubility.
PMID:19966469
A regimen of solid food in which the amount of hesperetin is controlled. Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside Hesperidin, is the predominant flavonoid in lemons and oranges.
slaulede
2021-08-27T15:51:49Z
CHEBI:28230
MESH:C013015
experimental_condition_ontology
XCO:0000896
controlled hesperetin content diet
XCO:0000896
A regimen of solid food in which the amount of hesperetin is controlled. Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside Hesperidin, is the predominant flavonoid in lemons and oranges.
drugbank:DB01094
This is an alkylamide found in some peppers that acts as an agonist at TRPV1 cation channels.
slaulede
2021-09-16T12:42:30Z
CHEBI:3374
PMID:27335281
(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
8-Methyl-N-Vanillyl-6-Nonenamide
Axsain
Capsaicine
experimental_condition_ontology
XCO:0000897
capsaicin
XCO:0000897
This is an alkylamide found in some peppers that acts as an agonist at TRPV1 cation channels.
MESH:D002211
This a pyrimidine N-oxide that is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure.
slaulede
2021-09-16T13:23:00Z
PMID:27335281
2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide
Rogaine
U 10858
experimental_condition_ontology
XCO:0000898
minoxidil
XCO:0000898
This a pyrimidine N-oxide that is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure.
CHEBI:6942
MESH:D008914
This is a thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
slaulede
2021-10-07T13:42:44Z
CHEBI:5778
PMID:3611778
Dichlothiazide
Dihydrochlorothiazide
experimental_condition_ontology
XCO:0000899
hydrochlorothiazide
XCO:0000899
This is a thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
MESH:D006852
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of hydrochlorothiazide in which the amount of hydrochlorothiazide consumed is maintained at a specified level.
slaulede
2021-10-07T14:29:25Z
CHEBI:5778
PMID:3611778
controlled Microzide content drinking water
controlled dichlothiazide content drinking water
controlled dihydrochlorothiazide content drinking water
experimental_condition_ontology
XCO:0000900
controlled hydrochlorothiazide content drinking water
XCO:0000900
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of hydrochlorothiazide in which the amount of hydrochlorothiazide consumed is maintained at a specified level.
https://www.merriam-webster.com/
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of delapril in which the amount of delapril consumed is maintained at a specified level.
slaulede
2021-10-07T15:05:11Z
CHEBI:135735
PMID:8505110
experimental_condition_ontology
XCO:0000901
controlled delapril content drinking water
XCO:0000901
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of delapril in which the amount of delapril consumed is maintained at a specified level.
https://www.merriam-webster.com/
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of candesartan in which the amount of candesartan consumed is maintained at a specified level.
slaulede
2021-10-07T15:17:01Z
CHEBI:3348
MESH:C081643
PMID:8505110
experimental_condition_ontology
XCO:0000902
controlled candesartan content drinking water
XCO:0000902
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of candesartan in which the amount of candesartan consumed is maintained at a specified level.
https://www.merriam-webster.com/
Technetium (99mTc) mebrofenin is a diagnostic radiopharmaceutical used for imaging of the liver and the gallbladder.
slaulede
2021-10-07T18:18:21Z
CHEBI:135608
PMID:30208622
99mTc-N-(3-bromo-2,4,6-trimethylphenylcarbamoilmethyl 1-iminodiacetic acid
Choletec
Technetium mebrofenin
experimental_condition_ontology
XCO:0000903
99mTc-mebrofenin
XCO:0000903
Technetium (99mTc) mebrofenin is a diagnostic radiopharmaceutical used for imaging of the liver and the gallbladder.
https://en.wikipedia.org/wiki/Technetium_(99mTc)_mebrofenin
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of resveratrol in which the amount of resveratrol consumed is maintained at a specified level.
slaulede
2021-10-08T18:16:04Z
MESH:D000077185
controlled 3,4',5-Stilbenetriol content drinking water
controlled RSV content drinking water
controlled SRT501 content drinking water
experimental_condition_ontology
XCO:0000904
controlled resveratrol content drinking water
XCO:0000904
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of resveratrol in which the amount of resveratrol consumed is maintained at a specified level.
PMID:30621358
https://www.merriam-webster.com/
Any condition in which the main influencing factor is castor oil, a mixture of triglycerides obtained by pressing the seeds of the castor oil plant, Ricinus communis It is used as a cathartic and as a plasticizer.
slaulede
2021-10-12T18:50:59Z
PMID:10023637
Ricinus communis oil
Ricinus oil
oil of Palma Christi
tangantangan oil
experimental_condition_ontology
XCO:0000905
castor oil
XCO:0000905
Any condition in which the main influencing factor is castor oil, a mixture of triglycerides obtained by pressing the seeds of the castor oil plant, Ricinus communis It is used as a cathartic and as a plasticizer.
CHEBI:140618
MESH:D002368
Any condition in which the main influencing factor is ovalbumin, the main protein found in egg white. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor.
slaulede
2021-10-14T16:18:19Z
https://en.wikipedia.org/wiki/Ovalbumin
OVA
experimental_condition_ontology
XCO:0000906
ovalbumin
XCO:0000906
Any condition in which the main influencing factor is ovalbumin, the main protein found in egg white. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor.
ISBN-13:9780781733908
https://en.wikipedia.org/wiki/Ovalbumin
Any condition in which the main influencing factor is liraglutide, a lipopeptide that is an analogue of human GLP-1 and an agonist of the GLP-1 receptor. Liraglutide is used as a hypoglycemic agent and supplemental therapy in the treatment of diabetes mellitus.
slaulede
2021-10-15T10:42:36Z
PMID:29976929
NN-2211
Saxenda
Victoza
experimental_condition_ontology
XCO:0000907
liraglutide
XCO:0000907
Any condition in which the main influencing factor is liraglutide, a lipopeptide that is an analogue of human GLP-1 and an agonist of the GLP-1 receptor. Liraglutide is used as a hypoglycemic agent and supplemental therapy in the treatment of diabetes mellitus.
CHEBI:71193
MESH:D000069450
A condition in which the main influencing factor is a metal sulfate composed of potassium, aluminium and sulfate ions in the ratio 1:1:2.
slaulede
2021-10-21T15:54:45Z
CHEBI:26218
MESH:C041524
AlK(SO4)2
alum
aluminium potassium sulfate
aluminum sulfate
potassium alum
experimental_condition_ontology
XCO:0000908
potassium aluminium sulfate
XCO:0000908
A condition in which the main influencing factor is a metal sulfate composed of potassium, aluminium and sulfate ions in the ratio 1:1:2.
CHEBI:86463
A condition in which the main influencing factor is any alkali metal salt having potassium(1+) as the cation.
slaulede
2021-10-21T16:00:13Z
CHEBI:26218
Kaliumsalz
potassium salts
experimental_condition_ontology
XCO:0000909
potassium salt
XCO:0000909
A condition in which the main influencing factor is any alkali metal salt having potassium(1+) as the cation.
CHEBI:26218
A regimen of solid food in which the amount of dehydroepiandrosterone consumed is controlled.
slaulede
2021-10-25T15:20:22Z
CHEBI:28689
MESH:D003687
PMID:9415976
controlled DHEA content diet
controlled androstenolone content diet
experimental_condition_ontology
XCO:0000910
controlled dehydroepiandrosterone content diet
XCO:0000910
A regimen of solid food in which the amount of dehydroepiandrosterone consumed is controlled.
PMID:9415976
This is any condition in which the main influencing factor is sodium bicarbonate, a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
slaulede
2021-10-25T17:24:20Z
PMID:29168078
baking soda
bicarbonate of soda
sodium hydrogen carbonate
sodium hydrogencarbonate
experimental_condition_ontology
XCO:0000911
sodium bicarbonate
XCO:0000911
This is any condition in which the main influencing factor is sodium bicarbonate, a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
MESH:D017693
Condition in which the environmental level and/or time of exposure to red light (wavelength range of 630–740 nm) is controlled.
slaulede
2021-10-26T18:33:13Z
PMID:28341233
experimental_condition_ontology
XCO:0000912
controlled exposure to red light
XCO:0000912
Condition in which the environmental level and/or time of exposure to red light (wavelength range of 630–740 nm) is controlled.
https://en.wikipedia.org/wiki/Red
Any condition in which the main influencing factor is ethosuximide, a dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. Ethosuximide is an antiepileptic used in the treatment of absence seizures and potentially myoclonic seizures, but is ineffective against tonic-clonic seizures.
slaulede
2021-10-29T11:04:35Z
MESH:D005013
PMID:30408474
3-ethyl-3-methylpyrrolidine-2,5-dione
Zarontin
experimental_condition_ontology
XCO:0000913
ethosuximide
XCO:0000913
Any condition in which the main influencing factor is ethosuximide, a dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. Ethosuximide is an antiepileptic used in the treatment of absence seizures and potentially myoclonic seizures, but is ineffective against tonic-clonic seizures.
CHEBI:4887
A dietary regimen in which access to food is unlimited and consists of energy-dense, highly palatable food. The diet is technically undefined as to ratio of components, but recapitulates the orosensory properties (such as smell and texture) and palatability of foodstuffs that promote overconsumption (voluntary hyperphagia). It has been proven to not only increase body weight and induce obesity, but to also cause metabolic syndrome, severe diabetic symptoms, liver inflammation, and other metabolic dysregulations.
slaulede
2021-10-29T14:53:10Z
Western diet
junk food diet
supermarket diet
experimental_condition_ontology
XCO:0000914
cafeteria diet
XCO:0000914
A dietary regimen in which access to food is unlimited and consists of energy-dense, highly palatable food. The diet is technically undefined as to ratio of components, but recapitulates the orosensory properties (such as smell and texture) and palatability of foodstuffs that promote overconsumption (voluntary hyperphagia). It has been proven to not only increase body weight and induce obesity, but to also cause metabolic syndrome, severe diabetic symptoms, liver inflammation, and other metabolic dysregulations.
PMID:33309818
Any condition in which the main influencing factor is a drink made up of water and a specified amount of ethanol, serving as a control condition for some chemical delivered in ethanol and drinking water.
slaulede
2021-11-01T12:46:32Z
PMID30621358
experimental_condition_ontology
XCO:0000915
controlled ethanol content drinking water used as vehicle
XCO:0000915
Any condition in which the main influencing factor is a drink made up of water and a specified amount of ethanol, serving as a control condition for some chemical delivered in ethanol and drinking water.
https://www.merriam-webster.com/
This is a regimen of semisolid food in which the amount of solid elements and water in the diet are controlled. The diet resembles jelly in consistency and is about 62.5% H2O, 37.5% synthetic food (Ziegler Bros., formula 53140000),0.3% NaCl, and 0.3% agar wt/wt.
slaulede
2021-11-30T17:49:55Z
gel diet
experimental_condition_ontology
gel-agar diet
semisolid diet
XCO:0000916
gelled diet
XCO:0000916
This is a regimen of semisolid food in which the amount of solid elements and water in the diet are controlled. The diet resembles jelly in consistency and is about 62.5% H2O, 37.5% synthetic food (Ziegler Bros., formula 53140000),0.3% NaCl, and 0.3% agar wt/wt.
PMID:12684228
The clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O), purified by successive evaporation and condensation. It is experimentally provided for hydration or as a vehicle control for some dissolved substance.
slaulede
2021-11-30T18:14:19Z
PMID:12684228
distilled H2O
experimental_condition_ontology
clarified water
purified water
XCO:0000917
distilled water
XCO:0000917
The clear, colorless, odorless, tasteless liquid each molecule of which contains one atom of oxygen and two atoms of hydrogen (H2O), purified by successive evaporation and condensation. It is experimentally provided for hydration or as a vehicle control for some dissolved substance.
ISBN-13:9780781733908
https://www.merriam-webster.com/
This is any condition in which the major influencing factor is atmospheric air in its natural state. The composition of ambient air varies depending on the elevation above sea level, but is typically 78% nitrogen and 21% oxygen.
slaulede
2021-12-07T15:31:29Z
atmospheric air
room air
experimental_condition_ontology
XCO:0000918
ambient air
XCO:0000918
This is any condition in which the major influencing factor is atmospheric air in its natural state. The composition of ambient air varies depending on the elevation above sea level, but is typically 78% nitrogen and 21% oxygen.
https://www.thermofisher.com
A nitrosamine that has methyl and 3-carboxypropyl substituents. It is a tobacco-derived nitrosamino acid that is a known animal and potential human carcinogen. It induces bladder transitional cell carcinomas in rats and has recently been identified as a contaminant in certain blood pressure medications.
slaulede
2022-02-03T13:23:56Z
PMID:32123074
pubchem.compound:13643
4-[methyl(nitroso)amino]butanoic acid
N-nitrosomethylaminobutyric acid
N-nitrosomethylbenzylamine
NMBA
experimental_condition_ontology
XCO:0000919
N-nitroso-N-methyl-4-aminobutyric acid
XCO:0000919
A nitrosamine that has methyl and 3-carboxypropyl substituents. It is a tobacco-derived nitrosamino acid that is a known animal and potential human carcinogen. It induces bladder transitional cell carcinomas in rats and has recently been identified as a contaminant in certain blood pressure medications.
CHEBI:176579
A regimen of solid food in which the amount of an inorganic element or compound containing a metal, nonmetal, radical, or phosphate that is needed for proper body function and maintenance of health, is controlled.
slaulede
2022-02-03T13:41:46Z
PMID:32123074
experimental_condition_ontology
XCO:0000920
controlled mineral content diet
XCO:0000920
A regimen of solid food in which the amount of an inorganic element or compound containing a metal, nonmetal, radical, or phosphate that is needed for proper body function and maintenance of health, is controlled.
ISBN-13:9780781733908
https://www.merriam-webster.com
A regimen of solid food in which the amount of zinc is controlled.
slaulede
2022-02-03T13:49:41Z
controlled Zn content diet
experimental_condition_ontology
XCO:0000921
controlled zinc content diet
XCO:0000921
A regimen of solid food in which the amount of zinc is controlled.
ISBN-13:9780781733908
https://www.merriam-webster.com
An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has been used to produce pulmonary arterial hypertension in animal models.
slaulede
2022-02-03T14:10:08Z
PMID:24113457
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
SU
SU 5416
SU5416
experimental_condition_ontology
XCO:0000922
semaxanib
XCO:0000922
An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has been used to produce pulmonary arterial hypertension in animal models.
CHEBI:91083
This is an experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery with Hespan buffer, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle.
slaulede
2022-02-08T16:35:19Z
PMID:7818325
isolated lung perfusion with HB
experimental_condition_ontology
XCO:0000923
isolated lung perfusion with Hespan buffer
XCO:0000923
This is an experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery with Hespan buffer, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle.
PMID:10155362
PMID:7818325
This is an experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery with a solution containing floxuridine, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle.
slaulede
2022-02-08T16:41:10Z
PMID:7818325
isolated lung perfusion with FUDR
experimental_condition_ontology
XCO:0000924
isolated lung perfusion with floxuridine
XCO:0000924
This is an experimental condition consisting of right or left thoracotomy with cannulation of pulmonary artery and vein, perfusion via artery with a solution containing floxuridine, and collection of effluent from pulmonary vein to prevent systemic circulation of treatment or vehicle.
ISBN-13:9780781733908
PMID:7818325
Bumetanide is a member of the class of benzoic acids, and a diuretic used for treatment of edema associated with congestive heart failure, hepatic and renal disease.
slaulede
2022-03-01T17:38:17Z
MESH:D002034
PMID:30385718
3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic aci
Bumex
Burinex
experimental_condition_ontology
XCO:0000925
bumetanide
XCO:0000925
Bumetanide is a member of the class of benzoic acids, and a diuretic used for treatment of edema associated with congestive heart failure, hepatic and renal disease.
CHEBI:3213
This is any condition in which the main influencing factor is a polyether compound, composed of repeating ethyleneoxy units, and derived from petroleum. Polyethylene glycol has many applications, including medical uses like in the composition of some laxatives.
slaulede
2022-03-07T11:51:41Z
PMID:32084371
PEG
PEO
POE
poly(ethylene oxide)
poly(oxyethylene)
polyethylene oxide
polyoxyethylene
experimental_condition_ontology
XCO:0000926
polyethylene glycol
XCO:0000926
This is any condition in which the main influencing factor is a polyether compound, composed of repeating ethyleneoxy units, and derived from petroleum. Polyethylene glycol has many applications, including medical uses like in the composition of some laxatives.
CHEBI:46793
https://en.wikipedia.org/wiki/Polyethylene_glycol
A hydroxyether compound containing more than one ether group.
slaulede
2022-03-07T11:58:38Z
PMID:32084371
experimental_condition_ontology
XCO:0000927
hydroxypolyether
XCO:0000927
A hydroxyether compound containing more than one ether group.
CHEBI:46789
This is a colonoscopy prep composed of 5.9% Macrogol 3350 (polyethylene glycol) and electrolytes.
slaulede
2022-03-07T12:43:59Z
Macrogol 3350
experimental_condition_ontology
XCO:0000928
ColonLYTELY
XCO:0000928
This is a colonoscopy prep composed of 5.9% Macrogol 3350 (polyethylene glycol) and electrolytes.
https://www.colonprep.com.au
Thia is a drink made up of water and a specified amount of ColonLYTELY (5.9% Macrogol 3350 solution) in which the amount of ColonLYTELY consumed is maintained at a specified level.
slaulede
2022-03-07T12:52:46Z
controlled Macrogol 3350 content drinking water
experimental_condition_ontology
XCO:0000929
controlled ColonLYTELY content drinking water
XCO:0000929
Thia is a drink made up of water and a specified amount of ColonLYTELY (5.9% Macrogol 3350 solution) in which the amount of ColonLYTELY consumed is maintained at a specified level.
PMID:32084371
https://www.colonprep.com.au
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidneys. It is followed by painting of the renal blood vessels with a solution of 10% phenol.
slaulede
2022-04-26T15:38:47Z
PMID:15894899
RDN
denervation of kidneys
surgical denervation of kidneys
experimental_condition_ontology
XCO:0000930
renal denervation
XCO:0000930
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidneys. It is followed by painting of the renal blood vessels with a solution of 10% phenol.
ISBN-13:978-0781733908
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is surgical narrowing of the lumen of the celiac artery and superior mesenteric artery.
slaulede
2022-04-26T16:02:24Z
PMID:15894899
experimental_condition_ontology
XCO:0000931
celiac artery and superior mesenteric artery constriction
XCO:0000931
This is any condition in which the main influencing factor is surgical narrowing of the lumen of the celiac artery and superior mesenteric artery.
ISBN-13:978-0781733908
https://www.merriam-webster.com/
This is a family of cyclic nonapeptide hormones found in most mammals. Synthesized in the hypothalamus and stored in the post-pituitary, vasopressins play a key role in homeostasis, particularly in regulating the body's water content. Vasopressin acts as a vasoconstrictor to increase blood pressure, blood volume, and water reabsorption by the renal collecting ducts.
slaulede
2022-04-26T16:45:16Z
ADH
AVP
antidiuretic hormone
experimental_condition_ontology
XCO:0000932
vasopressin
XCO:0000932
This is a family of cyclic nonapeptide hormones found in most mammals. Synthesized in the hypothalamus and stored in the post-pituitary, vasopressins play a key role in homeostasis, particularly in regulating the body's water content. Vasopressin acts as a vasoconstrictor to increase blood pressure, blood volume, and water reabsorption by the renal collecting ducts.
CHEBI:9937
MESH:D014667
This molecule is the predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.
slaulede
2022-04-26T16:50:12Z
Arg8-vasopressin
arg-vasopressin
arginine vasopressin
experimental_condition_ontology
XCO:0000933
argipressin
XCO:0000933
This molecule is the predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.
CHEBI:34543
MESH:D001127
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and both kidneys. It is followed by painting of the renal blood vessels with a solution of 10% phenol.
slaulede
2022-04-28T16:36:07Z
PMID:15894899
denervation of both kidneys
experimental_condition_ontology
XCO:0000934
bilateral renal denervation
XCO:0000934
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and both kidneys. It is followed by painting of the renal blood vessels with a solution of 10% phenol.
ISBN-13:978-0781733908
https://www.merriam-webster.com/
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and only one kidney, left or right. It is followed by painting of the renal blood vessels with a solution of 10% phenol.
slaulede
2022-04-28T16:39:29Z
PMID:15894899
denervation of a single kidney
experimental_condition_ontology
XCO:0000935
unilateral renal denervation
XCO:0000935
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and only one kidney, left or right. It is followed by painting of the renal blood vessels with a solution of 10% phenol.
ISBN-13:978-0781733908
https://www.merriam-webster.com/
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidney on the left side of the body. It is followed by painting of the left side renal blood vessels with a solution of 10% phenol.
slaulede
2022-04-28T16:47:06Z
PMID:15894899
left side renal denervation
experimental_condition_ontology
XCO:0000936
left kidney denervation
XCO:0000936
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidney on the left side of the body. It is followed by painting of the left side renal blood vessels with a solution of 10% phenol.
ISBN-13:978-0781733908
https://www.merriam-webster.com/
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidney on the right side of the body. It is followed by painting of the right side renal blood vessels with a solution of 10% phenol.
slaulede
2022-04-28T16:51:47Z
PMID:15894899
right side renal denervation
experimental_condition_ontology
XCO:0000937
right kidney denervation
XCO:0000937
This is the resection or complete surgical removal of the nerves that convey impulses between the central nervous system and the kidney on the right side of the body. It is followed by painting of the right side renal blood vessels with a solution of 10% phenol.
ISBN-13:978-0781733908
https://www.merriam-webster.com/
This is a serum albumin protein derived from cow blood. It is used as an enzyme-stabilizing agent, a blocking reagent, etc. for laboratory experiments.
slaulede
2022-04-28T17:42:46Z
PMID:15894899
BSA
Fraction V
https://en.wikipedia.org/wiki/Bovine_serum_albumin
experimental_condition_ontology
XCO:0000938
bovine serum albumin
XCO:0000938
This is a serum albumin protein derived from cow blood. It is used as an enzyme-stabilizing agent, a blocking reagent, etc. for laboratory experiments.
ISBN-13:978-0781733908
https://en.wikipedia.org/wiki/Bovine_serum_albumin
This is a hypoglycemic drug which enhances glucose-stimulated insulin secretion.
slaulede
2022-05-02T16:49:07Z
4-(4-Methylcyclohexyl)-4-oxobutanoic acid
4-(4beta-Methylcyclohexane-1-yl)-4-oxobutanoic acid
Cyclohexanebutanoic acid, 4-methyl-gamma-oxo-, trans-
trans - 4 - (4 - methylcyclohexyl) - 4 - oxobutyric acid
experimental_condition_ontology
XCO:0000939
JTT-608
XCO:0000939
This is a hypoglycemic drug which enhances glucose-stimulated insulin secretion.
PMID:10323602
This is an experimental condition in which the internal or external environment of a pancreas, the combined endocrine/exocrine gland situated transversely behind the stomach, between the spleen and the duodenum, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body.
slaulede
2022-05-05T16:23:16Z
PMID:10323602
experimental_condition_ontology
XCO:0000940
controlled ex vivo pancreas condition
XCO:0000940
This is an experimental condition in which the internal or external environment of a pancreas, the combined endocrine/exocrine gland situated transversely behind the stomach, between the spleen and the duodenum, is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body.
ISBN-13:978-0781733908
https://www.merriam-webster.com/
This is an experimental condition consisting of perfusion of the isolated pancreas with some physiological buffer (consisting of controlled solute composition and specific flow rate) in through the celiac artery and out through a portal vein.
slaulede
2022-05-05T16:44:35Z
PMID:10323602
PMID:1097860
experimental_condition_ontology
XCO:0000941
controlled ex vivo pancreas perfusion
XCO:0000941
This is an experimental condition consisting of perfusion of the isolated pancreas with some physiological buffer (consisting of controlled solute composition and specific flow rate) in through the celiac artery and out through a portal vein.
ISBN-13:978-0781733908
https://www.merriam-webster.com/
A solid diet in which the amount of saxagliptin, an oral antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor class, is maintained at a specified level.
slaulede
2022-05-27T17:31:25Z
CHEBI:71272
MESH:C502994
controlled 3-hydroxyadamantylglycine-4,5-methanoprolinenitrile hydrate content diet
controlled Onglyza content diet
experimental_condition_ontology
XCO:0000942
controlled saxagliptin content diet
XCO:0000942
A solid diet in which the amount of saxagliptin, an oral antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor class, is maintained at a specified level.
https://en.wikipedia.org/wiki/Saxagliptin
https://www.merriam-webster.com/
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of glucosamine in which the amount of glucosamine consumed is maintained at a specified level.
slaulede
2022-06-03T16:16:44Z
CHEBI:5417
PMID:22446865
controlled 2-amino-2-deoxyglucose content drinking water
experimental_condition_ontology
XCO:0000943
controlled glucosamine content drinking water
XCO:0000943
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of glucosamine in which the amount of glucosamine consumed is maintained at a specified level.
https://www.merriam-webster.com/
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of alendronate in which the amount of alendronate consumed is maintained at a specified level.
slaulede
2022-06-03T16:38:25Z
PMID:22446865
controlled Fosamax content drinking water
controlled sodium alendronate content drinking water
experimental_condition_ontology
controlled alendronic acid content drinking water
XCO:0000944
controlled alendronate content drinking water
XCO:0000944
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of alendronate in which the amount of alendronate consumed is maintained at a specified level.
http://en.wikipedia.org/wiki/Alendronic_acid
https://www.merriam-webster.com/
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of taxifolin in which the amount of taxifolin consumed is maintained at a specified level.
slaulede
2022-06-03T16:45:16Z
CHEBI:38747
PMID:22446865
controlled DHQ content drinking water
controlled catechin hydrate content drinking water
controlled dihydroquercetin content drinking water
experimental_condition_ontology
XCO:0000945
controlled taxifolin content drinking water
XCO:0000945
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of taxifolin in which the amount of taxifolin consumed is maintained at a specified level.
https://en.wikipedia.org/wiki/Taxifolin
https://www.merriam-webster.com/
This is a member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and originally designed as a potential therapy for excitotoxicity, epilepsy or neuropathic pain.
slaulede
2022-06-09T14:54:14Z
PMID:32507787
pubchem.compound:6435801
(2R4-[(2E)-3-phosphonoprop-2-en-1-yl]piperazine-2-carboxylic acid
CPPene
D-Cpp-ene
SDZ EAA 494
experimental_condition_ontology
XCO:0000946
midafotel
XCO:0000946
This is a member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and originally designed as a potential therapy for excitotoxicity, epilepsy or neuropathic pain.
CHEBI:180900
https://en.wikipedia.org/wiki/Midafotel
This is a condition in which the main influencing factor is a drug or agent that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
slaulede
2022-06-09T15:08:40Z
PMID:32507787
N-methyl-D-aspartate receptor antagonist
NMDAR antagonist
experimental_condition_ontology
XCO:0000947
NMDA receptor antagonist
XCO:0000947
This is a condition in which the main influencing factor is a drug or agent that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
CHEBI:60643
This is a condition in which the main influencing factor is a member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor.
slaulede
2022-06-09T15:23:24Z
MESH:C109643
PMID:32507787
4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
experimental_condition_ontology
XCO:0000948
Ro 25-6981
XCO:0000948
This is any condition in which the main influencing factor is PPDA, a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (NR2C/NR2D) containing receptors.
slaulede
2022-06-09T15:28:58Z
CAS:684283-16-7
PMID:32507787
(2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid
Cis-PPDA
cis-piperidine dicarboxylic acid
experimental_condition_ontology
XCO:0000949
PPDA
XCO:0000949
This is any condition in which the main influencing factor is PPDA, a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (NR2C/NR2D) containing receptors.
CHEBI:189866
This is any condition in which the main influencing factor is a drug or agent used to prevent seizures or reduce their severity. Anticonvulsants suppress the excessive rapid firing of neurons during seizures and prevent the spread of the seizure within the brain.
slaulede
2022-06-09T15:44:11Z
MESH:D000927
PMID:32507787
antiepileptic
antiepileptic drug
antiseizure drug
experimental_condition_ontology
XCO:0000950
anticonvulsant
XCO:0000950
This is any condition in which the main influencing factor is a drug or agent used to prevent seizures or reduce their severity. Anticonvulsants suppress the excessive rapid firing of neurons during seizures and prevent the spread of the seizure within the brain.
CHEBI:35623
https://en.wikipedia.org/wiki/Anticonvulsant
This is a condition in which the main influencing factor is an AMPA and KA receptor antagonist and a neuroprotectant for cerebral ischemia.
slaulede
2022-06-09T15:57:30Z
CAS:118876-58-7
CHEBI:31073
6-nitro-7-sulfamoylbenzo(f)quinoxaline-2,3-dione
NBQX
experimental_condition_ontology
XCO:0000951
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
XCO:0000951
This is a condition in which the main influencing factor is an AMPA and KA receptor antagonist and a neuroprotectant for cerebral ischemia.
MESH:C062865
PMID:32507787
This is a condition in which the main influencing factor is a drink made up of water and a specified amount of perindopril consumed by an organism as part of an experiment. Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, a potent, competitive inhibitor of ACE.
slaulede
2022-06-10T15:10:29Z
CHEBI:8024
MESH:D020913
PMID:12376396
controlled Aceon content drinking water
controlled Coversum content drinking water
controlled Coversyl content drinking water
experimental_condition_ontology
XCO:0000952
controlled perindopril content drinking water
XCO:0000952
This is a condition in which the main influencing factor is a drink made up of water and a specified amount of perindopril consumed by an organism as part of an experiment. Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, a potent, competitive inhibitor of ACE.
https://www.drugbank.ca/drugs/DB00790
https://www.merriam-webster.com/
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of reserpine consumed by an organism as part of an experiment. Reserpine is an indole alkaloid which irreversibly blocks the vesicular monoamine transporters (VMATs), SLC18A1 and SLC18A2, and has been used as both an antihypertensive drug and an antipsychotic drug.
slaulede
2022-06-10T16:51:15Z
CHEBI:28487
PMID:21107278
controlled Serpasil content drinking water
experimental_condition_ontology
XCO:0000953
controlled reserpine content drinking water
XCO:0000953
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of reserpine consumed by an organism as part of an experiment. Reserpine is an indole alkaloid which irreversibly blocks the vesicular monoamine transporters (VMATs), SLC18A1 and SLC18A2, and has been used as both an antihypertensive drug and an antipsychotic drug.
https://en.wikipedia.org/wiki/Reserpine
https://www.drugbank.ca/drugs/DB00206
This is a condition in which the main influencing factor is an aqueous mix of glucosamine and alendronic acid (the acid form of alendronate), two chemicals used to promote bone health.
slaulede
2022-06-16T17:17:55Z
CHEBI:50647
CHEBI:5417
GA
glucosamine alendronate
experimental_condition_ontology
XCO:0000954
glucosamine - alendronate
XCO:0000954
This is a condition in which the main influencing factor is an aqueous mix of glucosamine and alendronic acid (the acid form of alendronate), two chemicals used to promote bone health.
PMID:22446865
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of glucosamine - alendronate in which the amount of glucosamine - alendronate consumed is maintained at a specified level.
slaulede
2022-06-16T17:23:21Z
CHEBI:50647
CHEBI:5417
controlled GA content drinking water
controlled glucosamine alendronate content drinking water
experimental_condition_ontology
XCO:0000955
controlled glucosamine - alendronate content drinking water
XCO:0000955
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of glucosamine - alendronate in which the amount of glucosamine - alendronate consumed is maintained at a specified level.
PMID:22446865
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.14 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid.
slaulede
2022-06-30T16:30:19Z
PMID:15458950
aCSF with 0.14 M Na+
aCSF with 0.14 M sodium
artificial cerebrospinal fluid with 0.14 M Na+
experimental_condition_ontology
XCO:0000956
artificial cerebrospinal fluid with 0.14 M sodium
XCO:0000956
This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.14 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid.
PMID:15458950
https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid
This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.15 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid.
slaulede
2022-06-30T17:02:45Z
PMID:15458950
aCSF with 0.15 M Na+
aCSF with 0.15 M sodium
artificial cerebrospinal fluid with 0.15 M Na+
experimental_condition_ontology
XCO:0000957
artificial cerebrospinal fluid with 0.15 M sodium
XCO:0000957
This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.15 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid.
PMID:15458950
https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid
This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.16 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid.
slaulede
2022-06-30T17:07:23Z
PMID:15458950
aCSF with 0.16 M Na+
aCSF with 0.16 M sodium
artificial cerebrospinal fluid with 0.16 M Na+
experimental_condition_ontology
XCO:0000958
artificial cerebrospinal fluid with 0.16 M sodium
XCO:0000958
This is any condition in which the main influencing factor is artificial cerebrospinal fluid (aCSF) with a concentration of 0.16 M sodium ions. Artificial cerebrospinal fluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinal fluid.
PMID:15458950
https://en.wikipedia.org/wiki/Artificial_cerebrospinal_fluid
This is any condition in which the main influencing factor is a dichlorobenzene derivative that is a cell-permeable α2-adrenoceptor agonist used as an antihypertensive agent.
slaulede
2022-07-11T17:40:30Z
PMID:15458950
2,6-Dichlorobenzylideneaminoguanidine
Guanabenz
experimental_condition_ontology
XCO:0000959
Guanabenz
XCO:0000959
This is any condition in which the main influencing factor is a dichlorobenzene derivative that is a cell-permeable α2-adrenoceptor agonist used as an antihypertensive agent.
CHEBI:5553
MESH:D006143
This is a condition in which the level of carbon dioxide (10%), oxygen (20%), and nitrogen (70%) in the air surrounding the organism or breathed by the organism is controlled as part of the experiment.
slaulede
2022-07-18T18:12:29Z
PMID:21421817
experimental_condition_ontology
XCO:0000960
10% CO2, 20% O2, 70% N2
XCO:0000960
This is a condition in which the level of carbon dioxide (10%), oxygen (20%), and nitrogen (70%) in the air surrounding the organism or breathed by the organism is controlled as part of the experiment.
PMID:21421817
https://www.merriam-webster.com/
This is an experimental condition in which the internal or external environment of a heart is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body.
slaulede
2022-10-10T11:29:50Z
controlled isolated heart condition
experimental_condition_ontology
XCO:0000961
controlled ex vivo heart condition
XCO:0000961
This is an experimental condition in which the internal or external environment of a heart is experimentally manipulated or regulated, for example through perfusion, increased or decreased blood flow, etc. after removal from the body.
ISBN-13:978-0781733908
https://www.merriam-webster.com
This is an experimental condition consisting of perfusion (retrograde or forward) of the isolated heart with some physiological buffer (consisting of controlled solute composition and specific flow rate) through the aorta. In retrograde perfusion the backwards pressure causes the aortic valve to shut, forcing the solution into the coronary vessels, which normally supply the heart tissue with blood.
slaulede
2022-10-10T12:35:44Z
Langendorff heart perfusion
biventricular working heart perfusion
working (ejecting) heart perfusion
experimental_condition_ontology
XCO:0000962
controlled ex vivo heart perfusion
XCO:0000962
This is an experimental condition consisting of perfusion (retrograde or forward) of the isolated heart with some physiological buffer (consisting of controlled solute composition and specific flow rate) through the aorta. In retrograde perfusion the backwards pressure causes the aortic valve to shut, forcing the solution into the coronary vessels, which normally supply the heart tissue with blood.
https://www.harvardapparatus.com/physiology/isolated-organ-perfusion-studies/isolated-heart-perfusion-systems.html
https://www.merriam-webster.com
This is a drink made up of acidified water (pH 2.4-2.8) and a specified amount of the basic amino acid commonly known as L-NAME and used as a non-selective inhibitor of nitric oxide synthase, consumed by an organism as part of an experiment.
slaulede
2022-10-18T11:24:31Z
controlled L-NAME content in acidified drinking water
experimental_condition_ontology
XCO:0000963
controlled NG-nitroarginine methyl ester content in acidified drinking water
XCO:0000963
This is a drink made up of acidified water (pH 2.4-2.8) and a specified amount of the basic amino acid commonly known as L-NAME and used as a non-selective inhibitor of nitric oxide synthase, consumed by an organism as part of an experiment.
ISBN-13:978-0781733908
MESH:D019331
This is is perfluorinated octanoic acid, a fluoroalkanoic acid.
slaulede
2023-02-14T11:34:01Z
MESH:C023036
pentadecafluorooctanoic acid
experimental_condition_ontology
XCO:0000964
perfluorooctanoic acid
XCO:0000964
This is is perfluorinated octanoic acid, a fluoroalkanoic acid.
CHEBI:35549
This is any experimental condition in which cells derived from a multicellular organism are cultured and experimentally manipulated or regulated, for example through drug treatment or nutrient availability, in an artificial environment outside the living body.
slaulede
2023-02-14T12:04:36Z
controlled petri dish condition
controlled test tube condition
experimental_condition_ontology
XCO:0000965
controlled in vitro cell condition
XCO:0000965
This is any experimental condition in which cells derived from a multicellular organism are cultured and experimentally manipulated or regulated, for example through drug treatment or nutrient availability, in an artificial environment outside the living body.
ISBN-13:978-0781733908
https://www.merriam-webster.com
This is any experimental condition in which cultured cells are grown in a defined medium without added animal serum.
slaulede
2023-02-14T12:17:04Z
condition of growth medium without serum
serum starvation
experimental_condition_ontology
XCO:0000966
controlled serum-free condition
XCO:0000966
This is any experimental condition in which cultured cells are grown in a defined medium without added animal serum.
ISBN-13:978-0781733908
https://www.merriam-webster.com
This is is a type of weight-loss surgery that involves creating a small pouch from the stomach and connecting the newly created pouch directly to the small intestine. After gastric bypass, swallowed food will go into this small pouch of stomach and then directly into the small intestine, thereby bypassing most of the stomach and the first section of the small intestine.
slaulede
2023-02-27T18:10:08Z
Roux-en-Y gastric bypass
Roux-en-Y gastric bypass surgery
gastric bypass surgery
experimental_condition_ontology
XCO:0000967
gastric bypass
XCO:0000967
This is is a type of weight-loss surgery that involves creating a small pouch from the stomach and connecting the newly created pouch directly to the small intestine. After gastric bypass, swallowed food will go into this small pouch of stomach and then directly into the small intestine, thereby bypassing most of the stomach and the first section of the small intestine.
https://www.mayoclinic.org/tests-procedures/gastric-bypass-surgery/about/pac-20385189
https://www.merriam-webster.com
This is a condition induced by an experimental surgical procedure involving fluid percussion, cortical impact, or weight drop/impact acceleration to produce controlled injury to the surface of the brain.
slaulede
2023-02-27T18:45:54Z
experimental TBI
experimental_condition_ontology
XCO:0000968
experimental traumatic brain injury
XCO:0000968
This is a condition induced by an experimental surgical procedure involving fluid percussion, cortical impact, or weight drop/impact acceleration to produce controlled injury to the surface of the brain.
PMID:21876530
This is an experimental injury condition produced by a pendulum-and-piston-based device applying a brief fluid pressure pulse onto the intact dura after performing a craniectomy on the head of the subject.
slaulede
2023-03-02T13:40:02Z
LFPI
lateral fluid-percussion injury
parasagittal fluid percussion injury
experimental_condition_ontology
XCO:0000969
lateral fluid percussion injury
XCO:0000969
This is an experimental injury condition produced by a pendulum-and-piston-based device applying a brief fluid pressure pulse onto the intact dura after performing a craniectomy on the head of the subject.
PMID:19022291
PMID:21876530
This is any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of a protein kinase inhibitor. A protein kinase is an enzyme that regulates the biological activity of proteins by phosphorylation of specific amino acids with ATP as the source of phosphate, thereby inducing a conformational change from an inactive to an active form of the protein.
slaulede
2023-03-02T14:39:02Z
experimental_condition_ontology
XCO:0000970
protein kinase inhibitor
XCO:0000970
This is any condition in which the main influencing factor is a chemical which decreases or interferes with the activity of a protein kinase inhibitor. A protein kinase is an enzyme that regulates the biological activity of proteins by phosphorylation of specific amino acids with ATP as the source of phosphate, thereby inducing a conformational change from an inactive to an active form of the protein.
https://en.wikipedia.org/wiki/Protein_kinase
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/protein-kinases
This is any condition in which the main influencing factor is the chemical SB525334, which decreases or interferes with the activity of the serine/threonine protein kinase Alk5 (activin receptor-like kinase-5).
slaulede
2023-03-02T14:58:14Z
6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
SB 525334
TGF- beta RI Kinase Inhibitor VIII
experimental_condition_ontology
XCO:0000971
SB525334
XCO:0000971
This is any condition in which the main influencing factor is the chemical SB525334, which decreases or interferes with the activity of the serine/threonine protein kinase Alk5 (activin receptor-like kinase-5).
RGD:733386
This is any condition in which the main influencing factor is the chemical nintedanib, a member of the class of oxindoles that is a multi-kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis and cancer.
slaulede
2023-03-02T15:05:33Z
MESH:C530716
(Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Intedanib
Ofev
Vargatef
methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
experimental_condition_ontology
XCO:0000972
nintedanib
XCO:0000972
This is any condition in which the main influencing factor is the chemical nintedanib, a member of the class of oxindoles that is a multi-kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis and cancer.
CHEBI:85164
This is any condition in which the main influencing factor is the chemical sorafenib, a member of the class of phenylureas that are multi-kinase inhibitors and anti-neoplastic agents.
slaulede
2023-03-02T15:15:18Z
4-(4-(3-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)-N-METHYLPICOLINAMIDE
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
BAY 43-9006
Nexavar
experimental_condition_ontology
XCO:0000973
sorafenib
XCO:0000973
This is any condition in which the main influencing factor is the chemical sorafenib, a member of the class of phenylureas that are multi-kinase inhibitors and anti-neoplastic agents.
CHEBI:50924
This is a condition in which the main influencing factor is a surgical procedure causing blockage of the bile duct, which leads to acute obstructive jaundice and eventually to liver fibrosis.
slaulede
2023-03-02T15:29:13Z
CBDL
common bile duct ligation
experimental_condition_ontology
XCO:0000974
bile duct ligation
XCO:0000974
This is a condition in which the main influencing factor is a surgical procedure causing blockage of the bile duct, which leads to acute obstructive jaundice and eventually to liver fibrosis.
https://www.sciencedirect.com/topics/medicine-and-dentistry/bile-duct-ligation
This chlorocarbon is methane in which all the hydrogens have been replaced by chloro groups. It is a solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds.
slaulede
2023-03-06T12:33:48Z
CHEBI:27385
MESH:D002251
CCl4
tetrachloromethane
experimental_condition_ontology
XCO:0000975
carbon tetrachloride
XCO:0000975
This chlorocarbon is methane in which all the hydrogens have been replaced by chloro groups. It is a solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds.
CHEBI:27385
MESH:D002251
This is a chloroethene that is ethene substituted by chlorides at positions 1, 1 and 2. It is a highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent.
slaulede
2023-03-06T13:54:06Z
1,1,2-trichloroethene
trichloroethene
experimental_condition_ontology
XCO:0000976
trichlorethylene
XCO:0000976
This is a chloroethene that is ethene substituted by chlorides at positions 1, 1 and 2. It is a highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent.
CHEBI:16602
MESH:D014241
This is any experimental condition in which cells derived from a multicellular organism are cultured in medium enriched in amino acids, glucose, and other unique ingredients and supplemented with dexamethasone, penicillin/streptomycin, ITS+, GlutaMAX and HEPES; Gibco #CM4000. William's E Medium was originally developed by Williams and Gunn as reduced serum-supplemented medium for long-term cell cultures of adult rat liver epithelial cells.
slaulede
2023-03-06T14:19:01Z
PMID:31501904
supplemented WilliamÂ’s E Medium
experimental_condition_ontology
XCO:0000977
supplemented Williams' E Medium
XCO:0000977
This is any experimental condition in which cells derived from a multicellular organism are cultured in medium enriched in amino acids, glucose, and other unique ingredients and supplemented with dexamethasone, penicillin/streptomycin, ITS+, GlutaMAX and HEPES; Gibco #CM4000. William's E Medium was originally developed by Williams and Gunn as reduced serum-supplemented medium for long-term cell cultures of adult rat liver epithelial cells.
PMID:31501904
https://www.thermofisher.com/order/catalog/product/12551032
This is any condition in which the main influencing factor is an acetylated form of L-carnitine. It is naturally produced by the human body, and it is available as a dietary supplement. Acetyl-L-carnitine is broken down in the blood by plasma esterases to carnitine which is used by the body to transport fatty acids into the mitochondria for breakdown.
slaulede
2023-03-09T13:05:38Z
CHEBI:57589
MESH:D000108
ALC
ALCAR
L-ACETYLCARNITINE
L-acetyl-carnitine
LAC
O-Acetyl-L-carnitine
acetylcarnitine
experimental_condition_ontology
XCO:0000978
acetyl-L-carnitine
XCO:0000978
This is any condition in which the main influencing factor is an acetylated form of L-carnitine. It is naturally produced by the human body, and it is available as a dietary supplement. Acetyl-L-carnitine is broken down in the blood by plasma esterases to carnitine which is used by the body to transport fatty acids into the mitochondria for breakdown.
https://en.wikipedia.org/wiki/Acetylcarnitine
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of acetyl-L-carnitine in which the amount of acetyl-L-carnitine consumed is maintained at a specified level.
slaulede
2023-03-09T13:19:08Z
CHEBI:57589
MESH:D000108
controlled ALC content drinking water
controlled ALCAR content drinking water
controlled L-ACETYLCARNITINE L-ACETYLCARNITINE content drinking water
controlled L-acetyl-carnitine content drinking water
controlled LAC content drinking water
controlled O-Acetyl-L-carnitine content drinking water
controlled acetylcarnitine content drinking water
experimental_condition_ontology
XCO:0000979
controlled acetyl-L-carnitine content drinking water
XCO:0000979
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of acetyl-L-carnitine in which the amount of acetyl-L-carnitine consumed is maintained at a specified level.
ISBN-13:978-0781733908
https://www.merriam-webster.com
This is an experimental regimen of gelled food in which the amount of solid elements, water, and some other component(s) in the diet are controlled.
slaulede
2023-03-09T13:43:10Z
controlled content gel diet
experimental_condition_ontology
controlled content gel-agar diet
controlled content semisolid diet
XCO:0000980
controlled content gelled diet
XCO:0000980
This is an experimental regimen of gelled food in which the amount of solid elements, water, and some other component(s) in the diet are controlled.
PMID:12684228
https://www.merriam-webster.com
This is an experimental regimen of gelled food in which the amount of solid elements, water, and lithium chloride in the diet are controlled.
slaulede
2023-03-09T13:47:41Z
controlled LiCl content gelled diet
experimental_condition_ontology
XCO:0000981
controlled lithium chloride content gelled diet
XCO:0000981
This is an experimental regimen of gelled food in which the amount of solid elements, water, and lithium chloride in the diet are controlled.
PMID:12684228
PMID:31146973
This is a condition in which gene transfer has been performed using a lentivirus as the carrier of the genetic material. Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in humans and other mammalian species. Lentiviruses are distributed worldwide, and are known to be hosted in apes, cows, goats, horses, cats, and sheep as well as several other mammals.
slaulede
2023-03-13T13:28:54Z
lentiviral gene transfer
lentivirus transfer
experimental_condition_ontology
XCO:0000982
gene transfer using lentivirus vector
XCO:0000982
This is a condition in which gene transfer has been performed using a lentivirus as the carrier of the genetic material. Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in humans and other mammalian species. Lentiviruses are distributed worldwide, and are known to be hosted in apes, cows, goats, horses, cats, and sheep as well as several other mammals.
ISBN-13:978-0781733908
https://en.wikipedia.org/wiki/Lentivirus
This is a condition in which the enhanced green fluorescent protein (EGFP) gene has been (transiently or stably) transferred into a cell or organism using an lentivirus carrier in order to induce synthesis of EGFP in the recipient cell or organism.
slaulede
2023-03-13T13:41:04Z
gene transduction of the enhanced green fluorescent protein gene using a lentivirus vector
gene transfer of the eGFP gene using a lentivirus vector
gene transfer of the enhanced green fluorescent protein gene using a lentivirus vector
lentiviral transfer of the EGFP gene
transduction of recombinant lentivirus containing the EGFP gene
transfer of recombinant lentivirus containing the EGFP gene
experimental_condition_ontology
XCO:0000983
gene transfer of the EGFP gene using a lentivirus vector
XCO:0000983
This is a condition in which the enhanced green fluorescent protein (EGFP) gene has been (transiently or stably) transferred into a cell or organism using an lentivirus carrier in order to induce synthesis of EGFP in the recipient cell or organism.
PMID:28241067
https://www.merriam-webster.com
This is a condition in which the rat wild type cyclin Y gene (Ccny) has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of rat cyclin Y in the recipient cell or organism.
slaulede
2023-03-13T14:07:11Z
lentiviral transfer of the rat wild type Ccny gene
transfer of recombinant lentivirus containing the rat wild type Ccny gene
experimental_condition_ontology
XCO:0000984
gene transfer of the rat wild type Ccny gene using a lentivirus vector
XCO:0000984
This is a condition in which the rat wild type cyclin Y gene (Ccny) has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of rat cyclin Y in the recipient cell or organism.
PMID:26220330
This is a condition in which the rat wild type cyclin Y gene short hairpin RNA (Ccny-shRNA) has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to reduce synthesis of rat wild type cyclin Y in the recipient cell or organism.
slaulede
2023-03-13T14:27:37Z
lentiviral transfer of the rat wild type Ccny-specific shRNA
transduction of recombinant lentivirus containing the rat wild type-specific shRNA
transfer of recombinant lentivirus containing the rat wild type-specific shRNA
experimental_condition_ontology
XCO:0000985
transfer of rat wild type Ccny-specific shRNA using a lentivirus vector
XCO:0000985
This is a condition in which the rat wild type cyclin Y gene short hairpin RNA (Ccny-shRNA) has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to reduce synthesis of rat wild type cyclin Y in the recipient cell or organism.
PMID:28241067
https://www.merriam-webster.com
This is a condition in which the rat wild type cyclin Y gene short hairpin RNA (Ccny-shRNA) and enhanced green fluorescent protein (EGFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to reduce synthesis of rat wild type cyclin Y while inducing EGFP synthesis in the recipient cell or organism.
slaulede
2023-03-13T14:36:52Z
lentiviral transfer of the rat wild type Ccny-specific shRNA and the EGFP gene
transduction of recombinant lentivirus containing the rat wild type-specific shRNA and the EGFP gene
transfer of recombinant lentivirus containing the rat wild type-specific shRNA and the EGFP gene
experimental_condition_ontology
XCO:0000986
transfer of the rat wild type Ccny-specific shRNA and EGFP gene using a lentivirus vector
XCO:0000986
This is a condition in which the rat wild type cyclin Y gene short hairpin RNA (Ccny-shRNA) and enhanced green fluorescent protein (EGFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to reduce synthesis of rat wild type cyclin Y while inducing EGFP synthesis in the recipient cell or organism.
PMID:28241067
https://www.merriam-webster.com
This is a condition in which the rat wild type cyclin Y gene (Ccny-WT) and enhanced green fluorescent protein (EGFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of both rat wild type cyclin Y and EGFP in the recipient cell or organism.
slaulede
2023-03-13T14:42:14Z
lentiviral transfer of the rat wild type Ccny gene and the EGFP gene
transduction of recombinant lentivirus containing the rat wild type Ccny gene and the EGFP gene
transfer of recombinant lentivirus containing the rat wild type Ccny gene and the EGFP gene
experimental_condition_ontology
XCO:0000987
gene transfer of the rat wild type Ccny gene and EGFP gene using a lentivirus vector
XCO:0000987
This is a condition in which the rat wild type cyclin Y gene (Ccny-WT) and enhanced green fluorescent protein (EGFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of both rat wild type cyclin Y and EGFP in the recipient cell or organism.
PMID:28241067
https://www.merriam-webster.com
This is any experimental condition in which the main influencing factor is Dulbecco's Modified Eagle's Medium. Typically, cells derived from a multicellular organism are cultured in this synthetic medium originally formulated by Dulbecco and Freeman and based on Eagle's Minimal Essential Medium.
slaulede
2023-03-14T11:55:08Z
DMEM
DMEM, low glucose, pyruvate
experimental_condition_ontology
XCO:0000988
Dulbecco's Modified Eagle's Medium
XCO:0000988
This is any experimental condition in which the main influencing factor is Dulbecco's Modified Eagle's Medium. Typically, cells derived from a multicellular organism are cultured in this synthetic medium originally formulated by Dulbecco and Freeman and based on Eagle's Minimal Essential Medium.
https://en.wikipedia.org/wiki/Eagle%27s_minimal_essential_medium
https://www.thermofisher.com/us/en/home/technical-resources/media-formulation.48.html
This is any experimental condition in which the main influencing factor is fetal bovine serum. Fetal bovine serum is the most widely used serum-supplement for the in vitro cell culture of eukaryotic cells. Fetal bovine serum is derived from the blood drawn from a bovine fetus via a closed system of collection at a slaughterhouse.
slaulede
2023-03-14T12:20:39Z
FBS
fetal calf serum
experimental_condition_ontology
XCO:0000989
fetal bovine serum
XCO:0000989
This is any experimental condition in which the main influencing factor is fetal bovine serum. Fetal bovine serum is the most widely used serum-supplement for the in vitro cell culture of eukaryotic cells. Fetal bovine serum is derived from the blood drawn from a bovine fetus via a closed system of collection at a slaughterhouse.
PMID:13598821
https://en.wikipedia.org/wiki/Fetal_bovine_serum
This is any experimental condition in which the main influencing factor is Neurobasal medium, a culture medium formulated to meet the special requirements of neuronal cells. This medium allows for the long-term maintenance of normal phenotype and growth of neuronal cells, and the maintenance of pure populations of neuronal cells without the need of an astrocyte feeder layer.
slaulede
2023-03-14T12:39:34Z
PMID:26640375
experimental_condition_ontology
XCO:0000990
Neurobasal medium
XCO:0000990
This is any experimental condition in which the main influencing factor is Neurobasal medium, a culture medium formulated to meet the special requirements of neuronal cells. This medium allows for the long-term maintenance of normal phenotype and growth of neuronal cells, and the maintenance of pure populations of neuronal cells without the need of an astrocyte feeder layer.
https://www.thermofisher.com/us/en/home/technical-resources/media-formulation.251.html
This is any experimental condition in which the main influencing factor is GlutaMAX-I, a dipeptide (L-alanyl-L-glutamine) substitute for L-glutamine that can be used as a direct substitute for L-Glutamine at equimolar concentrations in mammalian and stem cell culture with minimal or no adaptation. L-alanyl-L-glutamine eliminates problems associated with the spontaneous breakdown of L-glutamine during incubation, is highly soluble in aqueous solution, and is heat stable.
slaulede
2023-03-14T14:17:15Z
PMID:26640375
L-alanyl-L-glutamine
experimental_condition_ontology
XCO:0000991
GlutaMAX-I
XCO:0000991
This is any experimental condition in which the main influencing factor is GlutaMAX-I, a dipeptide (L-alanyl-L-glutamine) substitute for L-glutamine that can be used as a direct substitute for L-Glutamine at equimolar concentrations in mammalian and stem cell culture with minimal or no adaptation. L-alanyl-L-glutamine eliminates problems associated with the spontaneous breakdown of L-glutamine during incubation, is highly soluble in aqueous solution, and is heat stable.
https://www.fishersci.com
This is any experimental condition in which the main influencing factor is B-27, an optimized serum-free supplement used to support the low- or high-density growth and short- or long-term viability of embryonic, post-natal, and adult hippocampal and other CNS neurons. It is meant to supplement a basal medium such as Neurobasal medium.
slaulede
2023-03-14T14:27:51Z
PMID:26640375
experimental_condition_ontology
XCO:0000992
B-27
XCO:0000992
This is any experimental condition in which the main influencing factor is B-27, an optimized serum-free supplement used to support the low- or high-density growth and short- or long-term viability of embryonic, post-natal, and adult hippocampal and other CNS neurons. It is meant to supplement a basal medium such as Neurobasal medium.
https://www.thermofisher.com/order/catalog/product/17504044
This is any experimental condition in which the main influencing factor is a controlled level of moisture in the air provided to an organism, ex vivo tissue, or cultured cells.
slaulede
2023-03-14T14:39:30Z
PMID:26640375
air H2O content
controlled H2O content air
controlled water content air
experimental_condition_ontology
XCO:0000993
controlled humidity
XCO:0000993
This is any experimental condition in which the main influencing factor is a controlled level of moisture in the air provided to an organism, ex vivo tissue, or cultured cells.
https://www.merriam-webster.com
This is any experimental condition in which the main influencing factor is StemPro NSC SFM, a serum-free culture medium formulated to meet the special requirements of neuronal stem cells. This medium supports expansion of both adherent and spheroid cultures, and differentiation capability into astrocytes, oligodendrocytes and neurons.
slaulede
2023-03-14T14:52:39Z
PMID:2664037
neuralstem cell serum free medium
experimental_condition_ontology
XCO:0000994
StemPro NSC SFM
XCO:0000994
This is any experimental condition in which the main influencing factor is StemPro NSC SFM, a serum-free culture medium formulated to meet the special requirements of neuronal stem cells. This medium supports expansion of both adherent and spheroid cultures, and differentiation capability into astrocytes, oligodendrocytes and neurons.
https://www.thermofisher.com/order/catalog/product/A1050901
This is any experimental condition in which the main influencing factor is a dimeric isoform of platelet-derived growth factor (PDGF-AA). All PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. PDGF appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.
slaulede
2023-03-14T15:14:58Z
PMID:26640375
platelet-derived growth factor-AA
platelet-derived growth factor-AA isoform
platelet-derived growth factor-alpha/alpha isoform
experimental_condition_ontology
XCO:0000995
PDGF-AA
XCO:0000995
This is any experimental condition in which the main influencing factor is a dimeric isoform of platelet-derived growth factor (PDGF-AA). All PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. PDGF appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.
https://www.thermofisher.com/antibody/product/Human-PDGF-AA-Animal-Free-Recombinant-Protein/AF-100-13A-1MG
This is any condition in which the main influencing factor is CHAER1 (cardiac hypertrophy associated epigenetic regulator 1) siRNA transfected by Lipofectamine. CHAER1 is an ncRNA involved in epigenetic regulation of gene expression. Lipofectamine is a proprietary formulation for transfecting small RNAs into cultured eukaryotic cells.
slaulede
2023-03-23T13:58:48Z
PMID:27618650
transfection of CHAER1 short interfering RNA using Lipofectamine reagent
transfection of CHAER1 siRNA using Lipofectamine reagent
transfection of CHAER1 silencing RNA using Lipofectamine reagent
transfection of CHAER1 small interfering RNA using Lipofectamine reagent
experimental_condition_ontology
XCO:0000996
transfer of CHAER1 siRNA using Lipofectamine reagent
XCO:0000996
This is any condition in which the main influencing factor is CHAER1 (cardiac hypertrophy associated epigenetic regulator 1) siRNA transfected by Lipofectamine. CHAER1 is an ncRNA involved in epigenetic regulation of gene expression. Lipofectamine is a proprietary formulation for transfecting small RNAs into cultured eukaryotic cells.
https://en.wikipedia.org/wiki/Small_interfering_RNA
https://www.thermofisher.com/us/en/home/life-science/cell-culture/transfection/transfection-reagents/lipofectamine-rnaimax-reagent.html
This is any condition in which the main influencing factor is negative control siRNA delivered with Lipofectamine. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences. Lipofectamine is a proprietary formulation for transfecting small RNAs into cultured eukaryotic cells.
slaulede
2023-03-23T14:11:37Z
PMID:27618650
transfection of negative control short interfering RNA using Lipofectamine reagent
transfection of negative control siRNA using Lipofectamine reagent
transfection of negative control silencing RNA using Lipofectamine reagent
transfection of negative control small interfering RNA using Lipofectamine reagent
experimental_condition_ontology
XCO:0000997
transfer of negative control siRNA using Lipofectamine reagent
XCO:0000997
This is any condition in which the main influencing factor is negative control siRNA delivered with Lipofectamine. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences. Lipofectamine is a proprietary formulation for transfecting small RNAs into cultured eukaryotic cells.
https://en.wikipedia.org/wiki/Small_interfering_RNA
https://www.thermofisher.com/us/en/home/life-science/cell-culture/transfection/transfection-reagents/lipofectamine-rnaimax-reagent.html
This is any condition in which the main influencing factor is control of the process of breathing, whether by the control of the volume of air breathed or by control of the contents of the breathed air. This may be for the treatment of disease or for the experimental study of physiology or pathology.
slaulede
2023-03-23T14:43:17Z
experimental_condition_ontology
XCO:0000998
controlled breathing condition
XCO:0000998
This is any condition in which the main influencing factor is control of the process of breathing, whether by the control of the volume of air breathed or by control of the contents of the breathed air. This may be for the treatment of disease or for the experimental study of physiology or pathology.
https://www.merriam-webster.com
This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator. The controlled parameters may be volume, pressure, and/or air component content.
slaulede
2023-03-23T14:49:38Z
controlled mechanical ventilation
experimental_condition_ontology
XCO:0000999
mechanical ventilation
XCO:0000999
This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator. The controlled parameters may be volume, pressure, and/or air component content.
ISBN-13:978-0781733908
https://my.clevelandclinic.org/health/treatments/15368-mechanical-ventilation
This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator with assist/control (A/C), meaning the breathing rate is set and the tidal volume or pressure is set. When the subject triggers a breath, a full set tidal volume (or pressure) breath is delivered. When the vent delivers a subject-triggered breath, the next breath is timed in relation to this.
slaulede
2023-03-23T15:26:05Z
A/C
assist/control
volume controlled ventilation
volume-controlled ventilation with constant tidal volumes
experimental_condition_ontology
XCO:0001000
mechanical ventilation with assist/control
XCO:0001000
This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator with assist/control (A/C), meaning the breathing rate is set and the tidal volume or pressure is set. When the subject triggers a breath, a full set tidal volume (or pressure) breath is delivered. When the vent delivers a subject-triggered breath, the next breath is timed in relation to this.
ISBN-13:978-0781733908
https://ventbasics.com/modes/modes-overview/
This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator with synchronized intermittent mandatory ventilation, meaning the breathing rate is set and the tidal volume is set with pressure support. The subject receives a set minimum number of breaths (the set rate) and any additional breaths are determined by the subject.
slaulede
2023-03-23T15:36:28Z
SIMV
experimental_condition_ontology
XCO:0001001
synchronized intermittent mandatory ventilation
XCO:0001001
This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator with synchronized intermittent mandatory ventilation, meaning the breathing rate is set and the tidal volume is set with pressure support. The subject receives a set minimum number of breaths (the set rate) and any additional breaths are determined by the subject.
ISBN-13:978-0781733908
https://ventbasics.com/modes/modes-overview/
This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator using variable tidal volume, or variable pressure support, and/or variable respiratory rate.
slaulede
2023-03-23T17:26:15Z
mechanical ventilation with variable tidal volume
experimental_condition_ontology
XCO:0001002
variable ventilation
XCO:0001002
This is any condition in which the main influencing factor is control of the process of breathing by a mechanical ventilator using variable tidal volume, or variable pressure support, and/or variable respiratory rate.
ISBN-13:978-0781733908
PMID:26979175
This is any condition in which the main influencing factor is a magnetic field, a vector field in the neighborhood of a magnet, electric current, or changing electric field in which magnetic forces are observable.
slaulede
2023-03-24T14:19:32Z
PMID:24407149
experimental_condition_ontology
XCO:0001003
magnetic field
XCO:0001003
This is any condition in which the main influencing factor is a magnetic field, a vector field in the neighborhood of a magnet, electric current, or changing electric field in which magnetic forces are observable.
https://byjus.com/physics/
https://www.merriam-webster.com
This is any condition in which the main influencing factor is a uniform magnetic field. A uniform magnetic field may be generated by an apparatus such as a Halbach cylinder. A Halbach cylinder is a magnetized cylinder composed of ferromagnetic material which can produce a uniform magnetic field across a plate of cultured cells which is surrounded by the cylinder.
slaulede
2023-03-24T14:51:33Z
PMID:24407149
experimental_condition_ontology
XCO:0001004
uniform magnetic field
XCO:0001004
This is any condition in which the main influencing factor is a uniform magnetic field. A uniform magnetic field may be generated by an apparatus such as a Halbach cylinder. A Halbach cylinder is a magnetized cylinder composed of ferromagnetic material which can produce a uniform magnetic field across a plate of cultured cells which is surrounded by the cylinder.
https://en.wikipedia.org/wiki/Halbach_array
https://en.wikipedia.org/wiki/Magnetism
This is any condition in which the main influencing factor is PIWIL1 (piwi-like RNA-mediated gene silencing 1) siRNA. The PIWIL1 protein may play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The pSUPER plasmid was designed for eukaryotic expression/RNAi.
slaulede
2023-03-28T17:14:00Z
PIWIL1 siRNA transfection
PMID:26104391
transfection of PIWIL1 siRNA using pSUPER plasmid
experimental_condition_ontology
XCO:0001005
transfer of PIWIL1 siRNA using pSUPER plasmid
XCO:0001005
This is any condition in which the main influencing factor is PIWIL1 (piwi-like RNA-mediated gene silencing 1) siRNA. The PIWIL1 protein may play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The pSUPER plasmid was designed for eukaryotic expression/RNAi.
PMID:26104391
https://www.addgene.org
This is any condition in which the main influencing factor is negative control siRNA delivered with a pSUPER plasmid. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental siRNA used.
slaulede
2023-03-28T17:21:28Z
negative control siRNA transfection
scrambled siRNA transfection
transfection of negative control siRNA using pSUPER plasmid
experimental_condition_ontology
XCO:0001006
transfer of negative control siRNA using pSUPER plasmid
XCO:0001006
This is any condition in which the main influencing factor is negative control siRNA delivered with a pSUPER plasmid. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental siRNA used.
PMID:26104391
https://www.addgene.org
This is any condition in which the main influencing factor is negative control shRNA delivered with a lentivirus vector. Negative control shRNA is an shRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental shRNA used.
slaulede
2023-03-31T11:00:04Z
transduction of negative control shRNA using a lentivirus
transduction of negative control shRNA using a lentivirus vector
transfer of negative control shRNA using a lentivirus
experimental_condition_ontology
XCO:0001007
transfer of negative control shRNA using a lentiviral vector
XCO:0001007
This is any condition in which the main influencing factor is negative control shRNA delivered with a lentivirus vector. Negative control shRNA is an shRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental shRNA used.
PMID:31606248
https://www.origene.com/products/cdna-clones/lentiviral-particles/control-particles
This is any condition in which the main influencing factor is Pum2 (pumilio RNA-binding family member 2) shRNA. Pum2 is a protein that exhibits lncRNA binding, miRNA binding, and mRNA 3'-UTR binding. Pum2 is involved in negative regulation of gene expression and regulation of intracellular mRNA localization.
slaulede
2023-03-31T11:37:24Z
transduction of Pum2 shRNA using a lentivirus
transduction of Pum2 shRNA using a lentivirus vector
transfer of Pum2 shRNA using a lentivirus
experimental_condition_ontology
XCO:0001008
transfer of Pum2 shRNA using a lentiviral vector
XCO:0001008
This is any condition in which the main influencing factor is Pum2 (pumilio RNA-binding family member 2) shRNA. Pum2 is a protein that exhibits lncRNA binding, miRNA binding, and mRNA 3'-UTR binding. Pum2 is involved in negative regulation of gene expression and regulation of intracellular mRNA localization.
PMID:31606248
https://blog.addgene.org
This is any experimental condition in which the main influencing factor is M199 medium, which is useful across a wide range of species and applications but is particularly suitable for the culturing of non-transformed cells. M199 medium ingredients may include EarleÂ’s salts and a bicarbonate/carbonic acid buffering system for the maintenance of pH in a CO2 incubator or HankÂ’s salts with salt solutions designed for atmospheric equilibrium.
slaulede
2023-04-06T12:56:12Z
PMID:31283468
M199
M199 media
M199 medium
Medium 199
experimental_condition_ontology
XCO:0001009
Media 199
XCO:0001009
This is any experimental condition in which the main influencing factor is M199 medium, which is useful across a wide range of species and applications but is particularly suitable for the culturing of non-transformed cells. M199 medium ingredients may include EarleÂ’s salts and a bicarbonate/carbonic acid buffering system for the maintenance of pH in a CO2 incubator or HankÂ’s salts with salt solutions designed for atmospheric equilibrium.
https://www.thermofisher.com
This is any experimental condition in which the main influencing factor is glutamine, an alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4. Glutamine is used as a supplement in cell culture media.
slaulede
2023-04-06T13:12:19Z
CHEBI:28300
L-glutamine
experimental_condition_ontology
XCO:0001010
glutamine
XCO:0001010
This is any experimental condition in which the main influencing factor is glutamine, an alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4. Glutamine is used as a supplement in cell culture media.
CHEBI:28300
https://www.merriam-webster.com
This is any experimental condition in which the main influencing factor is a mixture of penicillin G and streptomycin (penicillin-streptomycin) that is widely used in mammalian cell culture media to prevent bacterial contamination. The solution contains 5,000 units of penicillin G (sodium salt) which acts as the active base, and 5,000 micrograms of streptomycin (sulfate) (base per milliliter), formulated in 0.85% saline.
slaulede
2023-04-06T13:28:20Z
PMID:31283468
Pen-Strep
experimental_condition_ontology
XCO:0001011
penicillin-streptomycin
XCO:0001011
This is any experimental condition in which the main influencing factor is a mixture of penicillin G and streptomycin (penicillin-streptomycin) that is widely used in mammalian cell culture media to prevent bacterial contamination. The solution contains 5,000 units of penicillin G (sodium salt) which acts as the active base, and 5,000 micrograms of streptomycin (sulfate) (base per milliliter), formulated in 0.85% saline.
https://en.wikipedia.org/wiki/Pen-Strep
This is a condition in which the rat Rbpms (RNA binding protein, mRNA processing factor) gene has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of Rbpms in the recipient cell or organism.
slaulede
2023-04-06T14:09:22Z
gene transfer of rat Rbpms using a lentiviral vector
gene transfer of rat Rbpms using a lentivirus vector
transduction of rat Rbpms using a lentiviral vector
transduction of rat Rbpms using a lentivirus vector
experimental_condition_ontology
XCO:0001012
gene transfer of the rat Rbpms gene using a lentivirus vector
XCO:0001012
This is a condition in which the rat Rbpms (RNA binding protein, mRNA processing factor) gene has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of Rbpms in the recipient cell or organism.
PMID:31283468
https://www.merriam-webster.com
This is any condition in which the main influencing factor is rat RBPMS (RNA binding protein, mRNA processing factor)-specific siRNA. This siRNA has been transferred into a cell or organism using a lentivirus carrier in order to block synthesis of RBPMS in the recipient cell or organism.
slaulede
2023-04-06T14:34:10Z
PMID:31283468
transduction of RBPMS siRNA using a lentivirus vector
experimental_condition_ontology
XCO:0001013
transfer of rat RBPMS siRNA using a lentivirus vector
XCO:0001013
This is any condition in which the main influencing factor is rat RBPMS (RNA binding protein, mRNA processing factor)-specific siRNA. This siRNA has been transferred into a cell or organism using a lentivirus carrier in order to block synthesis of RBPMS in the recipient cell or organism.
PMID:31283468
https://en.wikipedia.org/wiki/Small_interfering_RNA
This is any condition in which the main influencing factor is negative control siRNA delivered with a lentivirus vector. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental siRNA used.
slaulede
2023-04-06T14:42:17Z
transduction of negative control siRNA using a lentivirus
transduction of negative control siRNA using a lentivirus vector
transfer of negative control siRNA using a lentivirus
experimental_condition_ontology
XCO:0001014
transfer of negative control siRNA using a lentiviral vector
XCO:0001014
This is any condition in which the main influencing factor is negative control siRNA delivered with a lentivirus vector. Negative control siRNA is an siRNA with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental siRNA used.
PMID:31283468
https://www.origene.com/products/cdna-clones/lentiviral-particles/control-particles
This is any condition in which the main influencing factor is creating a volumetric muscle loss (VML) of 20% or more of the total amount of mass in the targeted muscle through surgical removal (myectomy).
slaulede
2023-04-06T16:01:25Z
PMID:29531830
experimental_condition_ontology
XCO:0001015
myectomy
XCO:0001015
This is any condition in which the main influencing factor is creating a volumetric muscle loss (VML) of 20% or more of the total amount of mass in the targeted muscle through surgical removal (myectomy).
PMID:34146835
https://study.com/
This is any condition in which the main influencing factor is implantation of a minced muscle graft. It is a surgical procedure intended to induce healing of a skeletal muscle injured by volumetric muscle loss.
slaulede
2023-04-06T16:32:30Z
PMID:29531830
MMG
autologous minced muscle graft
experimental_condition_ontology
XCO:0001016
minced muscle graft
XCO:0001016
This is any condition in which the main influencing factor is implantation of a minced muscle graft. It is a surgical procedure intended to induce healing of a skeletal muscle injured by volumetric muscle loss.
PMID:29531830
This is a bitter crystalline alkaloid C17H21NO4 obtained from coca leaves that is used especially in the form of its hydrochloride medically as a topical anesthetic and illicitly for its euphoric effects and that may result in a compulsive psychological need.
slaulede
2023-04-27T12:51:11Z
CHEBI:27958
MESH:D003042
(1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate
experimental_condition_ontology
XCO:0001017
cocaine
XCO:0001017
This is a bitter crystalline alkaloid C17H21NO4 obtained from coca leaves that is used especially in the form of its hydrochloride medically as a topical anesthetic and illicitly for its euphoric effects and that may result in a compulsive psychological need.
https://www.merriam-webster.com
This is an organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group.
slaulede
2023-04-27T13:02:47Z
MESH:C070417
WIN 55,212
[(3R)-5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl](1-naphthyl)methanone
experimental_condition_ontology
XCO:0001018
WIN 55,212-2
XCO:0001018
This is an organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group.
CHEBI:73295
This is any condition in which the main influencing factor is olanzapine, a benzodiazepine derivative that binds SEROTONIN RECEPTORS; MUSCARINIC RECEPTORS; HISTAMINE H1 RECEPTORS; ADRENERGIC ALPHA-1 RECEPTORS; and DOPAMINE RECEPTORS. It is an antipsychotic agent used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER; and MAJOR DEPRESSIVE DISORDER; it may also reduce nausea and vomiting in patients undergoing chemotherapy.
slaulede
2023-05-02T13:01:59Z
CHEBI:7735
MESH:D000077152
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
experimental_condition_ontology
XCO:0001019
olanzapine
XCO:0001019
This is any condition in which the main influencing factor is olanzapine, a benzodiazepine derivative that binds SEROTONIN RECEPTORS; MUSCARINIC RECEPTORS; HISTAMINE H1 RECEPTORS; ADRENERGIC ALPHA-1 RECEPTORS; and DOPAMINE RECEPTORS. It is an antipsychotic agent used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER; and MAJOR DEPRESSIVE DISORDER; it may also reduce nausea and vomiting in patients undergoing chemotherapy.
MESH:D000077152
This is any condition in which the main influencing factor is docosahexaenoic acid, a C22 polyunsaturated fatty acid containing six double bonds.
slaulede
2023-05-02T13:31:17Z
CHEBI:36005
DHA
cervonic acid
experimental_condition_ontology
XCO:0001020
docosahexaenoic acid
XCO:0001020
This is any condition in which the main influencing factor is docosahexaenoic acid, a C22 polyunsaturated fatty acid containing six double bonds.
CHEBI:36005
This is any condition in which the main influencing factor is a solid diet in which the amount of docosahexaenoic acid, a C22 polyunsaturated fatty acid containing six double bonds, is maintained at a specified level.
slaulede
2023-05-02T13:37:56Z
CHEBI:36005
PMID:27322469
controlled DHA content diet
experimental_condition_ontology
XCO:0001021
controlled docosahexaenoic acid content diet
XCO:0001021
This is any condition in which the main influencing factor is a solid diet in which the amount of docosahexaenoic acid, a C22 polyunsaturated fatty acid containing six double bonds, is maintained at a specified level.
CHEBI:36005
This is any condition in which the main influencing factor is flaxseed oil, an edible oil in demand as a dietary supplement, as a source of α-Linolenic acid, an omega-3 fatty acid.
slaulede
2023-05-02T13:50:29Z
flax oil
linseed oil
experimental_condition_ontology
XCO:0001022
flaxseed oil
XCO:0001022
This is any condition in which the main influencing factor is flaxseed oil, an edible oil in demand as a dietary supplement, as a source of α-Linolenic acid, an omega-3 fatty acid.
https://en.wikipedia.org/wiki/Linseed_oil
This is any condition in which the main influencing factor is a solid diet in which the amount of flaxseed oil, an edible oil rich in α-Linolenic acid (an omega-3 fatty acid), is maintained at a specified level.
slaulede
2023-05-02T13:57:19Z
PMID:27322469
controlled flaxs oil content diet
controlled linseed oil content diet
experimental_condition_ontology
XCO:0001023
controlled flaxseed oil content diet
XCO:0001023
This is any condition in which the main influencing factor is a solid diet in which the amount of flaxseed oil, an edible oil rich in α-Linolenic acid (an omega-3 fatty acid), is maintained at a specified level.
https://en.wikipedia.org/wiki/Linseed_oil
This is any condition in which the main influencing factor is BNTA, a small molecule with ECM modulatory and anti-inflammatory properties that is a potential therapeutic agent for osteoarthritis.
slaulede
2023-05-09T14:19:20Z
CID:2819453
N-(2-bromo-4-(phenylsulfonyl)thiophen-3-yl)-2-chlorobenzamide
N-[2-bromo-4-(phenylsulfonyl)-3-thienyl]-2-chlorobenzamide
N-[4-(benzenesulfonyl)-2-bromothiophen-3-yl]-2-chlorobenzamide
experimental_condition_ontology
XCO:0001024
BNTA
XCO:0001024
This is any condition in which the main influencing factor is BNTA, a small molecule with ECM modulatory and anti-inflammatory properties that is a potential therapeutic agent for osteoarthritis.
PMID:31015473
This is any condition in which the main influencing factor is UNC0638, a histone methyltransferase Inhibitor that is a trial drug for cancer.
slaulede
2023-05-09T15:04:55Z
PMID:26551542
2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine
DNA MTase Inhibitor III
DNA Methyltransferase Inhibitor III
EHMT1/GLP Inhibitor II
EHMT2/G9a Inhibitor IV
HMTase Inhibitor IV
experimental_condition_ontology
XCO:0001025
UNC0638
XCO:0001025
This is any condition in which the main influencing factor is UNC0638, a histone methyltransferase Inhibitor that is a trial drug for cancer.
https://www.sigmaaldrich.com/US/en/product/mm/382192
This is any condition in which the main influencing factor is the tight ligation of one or more segmental spinal nerves at a point before the spinal nerve joins a common nerve (most commonly: ligation of L5 and/or L6 nerves which, with L4, make up the sciatic nerve in rats). This is a model of chronic neuropathic pain.
slaulede
2023-05-09T16:38:20Z
SNL
experimental_condition_ontology
Chung model
SNL model
XCO:0001026
spinal nerve ligation
XCO:0001026
This is any condition in which the main influencing factor is the tight ligation of one or more segmental spinal nerves at a point before the spinal nerve joins a common nerve (most commonly: ligation of L5 and/or L6 nerves which, with L4, make up the sciatic nerve in rats). This is a model of chronic neuropathic pain.
PMID:1333581
https://link.springer.com/referenceworkentry/10.1007/978-3-540-29805-2_2683
This is a condition in which the Rpl10a (ribosomal protein L10A) gene has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of Rpl10a in the recipient cell or organism.
slaulede
2023-05-11T15:08:39Z
gene transfer of Rpl10a using a lentivirus vector
transduction of Rpl10a using a lentiviral vector
transduction of ribosomal protein L10A using a lentiviral vector
transduction of ribosomal protein L10A using a lentivirus vector
experimental_condition_ontology
XCO:0001027
gene transfer of the Rpl10a gene using a lentivirus vector
XCO:0001027
This is a condition in which the Rpl10a (ribosomal protein L10A) gene has been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of Rpl10a in the recipient cell or organism.
PMID:31825308
https://www.merriam-webster.com
This is a condition in which the enhanced yellow fluorescent protein (EYFP) gene has been (transiently or stably) transferred into a cell or organism using an lentivirus carrier in order to induce synthesis of EYFP in the recipient cell or organism.
slaulede
2023-05-11T15:33:38Z
gene transduction of the enhanced yellow fluorescent protein gene using a lentivirus vector
gene transfer of the EYFP gene using a lentivirus vector
lentiviral transfer of the EYFP gene
transduction of recombinant lentivirus containing the EYFP gene
transfer of recombinant lentivirus containing the EYFP gene
experimental_condition_ontology
XCO:0001028
gene transfer of the EYFP gene using a lentivirus vector
XCO:0001028
This is a condition in which the enhanced yellow fluorescent protein (EYFP) gene has been (transiently or stably) transferred into a cell or organism using an lentivirus carrier in order to induce synthesis of EYFP in the recipient cell or organism.
PMID:31825308
https://www.merriam-webster.com
This is a condition in which the Rpl10a (ribosomal protein L10A) gene and enhanced yellow fluorescent protein (EYFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of both rat wild type cyclin Y and EGFP in the recipient cell or organism.
slaulede
2023-05-11T15:56:41Z
lentiviral transfer of the Rpl10a gene and the EYFP gene
transduction of recombinant lentivirus containing the Rpl10a gene and the EYFP gene
transfer of recombinant lentivirus containing the Rpl10a gene and the EYFP gene
experimental_condition_ontology
XCO:0001029
gene transfer of the Rpl10a gene and EYFP gene using a lentivirus vector
XCO:0001029
This is a condition in which the Rpl10a (ribosomal protein L10A) gene and enhanced yellow fluorescent protein (EYFP) gene have been (transiently or stably) transferred into a cell or organism using a lentivirus carrier in order to induce synthesis of both rat wild type cyclin Y and EGFP in the recipient cell or organism.
PMID:31825308
https://www.merriam-webster.com
This is any condition in which the main influencing factor is acupuncture, a technique in which practitioners insert fine needles into the skin to treat health problems. The needles may be manipulated manually or stimulated with small electrical currents (electroacupuncture). Acupuncture has been in use in some form for at least 2,500 years.
slaulede
2023-05-12T14:51:55Z
MESH:D015670
acupotomy
acupuncture treatment
pharmacoacupuncture therapy
pharmacoacupuncture treatment
experimental_condition_ontology
XCO:0001030
acupuncture
XCO:0001030
This is any condition in which the main influencing factor is acupuncture, a technique in which practitioners insert fine needles into the skin to treat health problems. The needles may be manipulated manually or stimulated with small electrical currents (electroacupuncture). Acupuncture has been in use in some form for at least 2,500 years.
https://www.nccih.nih.gov/health/acupuncture-what-you-need-to-know
This is any condition in which the main influencing factor is electroacupuncture, a form of acupuncture where a small electric current is passed between pairs of acupuncture needles. According to some acupuncturists, this practice augments the use of regular acupuncture, can restore health and well-being, and is particularly good for treating pain.
slaulede
2023-05-12T14:58:31Z
MESH:D015671
PMID:24722278
electro-acupuncture
experimental_condition_ontology
XCO:0001031
electroacupuncture
XCO:0001031
This is any condition in which the main influencing factor is electroacupuncture, a form of acupuncture where a small electric current is passed between pairs of acupuncture needles. According to some acupuncturists, this practice augments the use of regular acupuncture, can restore health and well-being, and is particularly good for treating pain.
https://en.wikipedia.org/wiki/Electroacupuncture
This is any condition in which the main influencing factor is neural progenitor cells, which are isolated from embryonic or fetal CNS tissue and can be expanded in culture for prolonged periods using genetic or epigenetic approaches. Expanded cells have the capacity to differentiate into neurons, oligodendrocytes, or astrocytes.
slaulede
2023-05-18T14:23:53Z
hNPCs
experimental_condition_ontology
XCO:0001032
human neural progenitor cells
XCO:0001032
This is any condition in which the main influencing factor is neural progenitor cells, which are isolated from embryonic or fetal CNS tissue and can be expanded in culture for prolonged periods using genetic or epigenetic approaches. Expanded cells have the capacity to differentiate into neurons, oligodendrocytes, or astrocytes.
PMID:18341406
This is any condition in which the main influencing factor is a balanced salt solution-based medium for the delivery of a suspension of cells.
slaulede
2023-05-18T14:35:36Z
BSS cell carrying medium
experimental_condition_ontology
XCO:0001033
balanced salt solution cell carrying medium
XCO:0001033
This is any condition in which the main influencing factor is a balanced salt solution-based medium for the delivery of a suspension of cells.
PMID:27217715
This is any condition in which the main influencing factor is hawk tea extract (HTE), a potential cholesterol-lowering agent and antioxidant. Hawk tea is a medicinal herbal and caffeine-free drink popular in China.
slaulede
2023-05-19T13:15:55Z
HTE
Litsea coreana Levl. var. lanuginose extract
Litsea coreana extract
experimental_condition_ontology
XCO:0001034
hawk tea extract
XCO:0001034
This is any condition in which the main influencing factor is hawk tea extract (HTE), a potential cholesterol-lowering agent and antioxidant. Hawk tea is a medicinal herbal and caffeine-free drink popular in China.
PMID:31098406
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of hawk tea extract consumed by an organism as part of an experiment. Hawk tea extract is a potential cholesterol-lowering agent and antioxidant. Hawk tea is a traditional herbal and caffeine-free drink popular in China.
slaulede
2023-05-19T13:25:24Z
PMID:23618259
controlled Litsea coreana extract content drinking water
controlled hawk tea extract content drinking water
experimental_condition_ontology
XCO:0001035
controlled HTE content drinking water
XCO:0001035
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of hawk tea extract consumed by an organism as part of an experiment. Hawk tea extract is a potential cholesterol-lowering agent and antioxidant. Hawk tea is a traditional herbal and caffeine-free drink popular in China.
PMID:31098406
This is any condition in which the major influencing factor is the peptide (TESPFKNTEISFKLGQEFEETTADNR) representing residues 53 to 78 of peripheral myelin protein 2, a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins.
slaulede
2023-05-19T13:48:55Z
Pmp2 peptide 53-78
TESPFKNTEISFKLGQEFEETTADNR
experimental_condition_ontology
XCO:0001036
peripheral myelin protein 2 peptide 53-78
XCO:0001036
This is any condition in which the major influencing factor is the peptide (TESPFKNTEISFKLGQEFEETTADNR) representing residues 53 to 78 of peripheral myelin protein 2, a fatty acid and cholesterol binding protein which together with myelin basic protein constitutes a major fraction of the peripheral nervous system myelin proteins.
PMID:31344254
This is any condition in which the main influencing factor is Mycobacterium tuberculosis H37Ra (a high G+C gram-positive bacteria) introduced externally or internally, alive or dead, to a subject to effect a change in phenotype of the subject
slaulede
2023-05-19T14:35:05Z
PMID:31344254
UniProt:419947
MYCTA
Mycobacterium tuberculosis ATCC 25177
Mycobacterium tuberculosis strain H37Ra
experimental_condition_ontology
XCO:0001037
Mycobacterium tuberculosis H37Ra
XCO:0001037
This is any condition in which the main influencing factor is Mycobacterium tuberculosis H37Ra (a high G+C gram-positive bacteria) introduced externally or internally, alive or dead, to a subject to effect a change in phenotype of the subject
NCBI:txid419947
This is any condition in which the main influencing factor is PBS-filled liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and containing phosphate buffered saline.
slaulede
2023-05-19T16:16:35Z
PBS containing liposomes
PBS-liposomes
phosphate buffered saline-filled liposomes
experimental_condition_ontology
XCO:0001038
PBS-filled liposomes
XCO:0001038
This is any condition in which the main influencing factor is PBS-filled liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and containing phosphate buffered saline.
PMID:30485549
This is any condition in which the main influencing factor is clodronate-filled liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and containing clodronate.
slaulede
2023-05-19T16:23:46Z
http://clodronateliposomes.com/
clodronate containing liposomes
clodronate liposomes
experimental_condition_ontology
XCO:0001039
Clodronate-filled liposomes
XCO:0001039
This is any condition in which the main influencing factor is clodronate-filled liposomes, artificial vesicles composed of one or more concentric phospholipid bilayers and containing clodronate.
PMID:30485549
This is any condition in which the main influencing factor is (R)-lipoic acid, the (R)-enantiomer of lipoic acid. Lipoic acid is a vitamin-like, C8 thia fatty acid with anti-oxidant properties.
slaulede
2023-05-23T16:56:01Z
MESH:D008063
PMID:24104204
R-α-lipoic acid
experimental_condition_ontology
XCO:0001040
(R)-lipoic acid
XCO:0001040
This is any condition in which the main influencing factor is (R)-lipoic acid, the (R)-enantiomer of lipoic acid. Lipoic acid is a vitamin-like, C8 thia fatty acid with anti-oxidant properties.
CHEBI:30314
This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy and delivery of a controlled contusion of the spinal cord by a mechanical apparatus.
slaulede
2023-05-26T10:20:43Z
spinal cord injury
PMID:15629760
PMID:28106101
experimental_condition_ontology
XCO:0001041
experimental spinal cord contusion
XCO:0001041
This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy and delivery of a controlled contusion of the spinal cord by a mechanical apparatus.
PMID:15629760
This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy of the ninth thoracic vertebra and delivery of a controlled contusion of the spinal cord by a mechanical apparatus.
slaulede
2023-05-26T10:31:57Z
spinal cord injury at the ninth thoracic vertebra
spinal cord injury at T9
spinal cord contusion at T9
experimental_condition_ontology
XCO:0001042
T9 spinal cord contusion
XCO:0001042
This is any condition in which the main influencing factor is an experimental surgical procedure involving laminectomy of the ninth thoracic vertebra and delivery of a controlled contusion of the spinal cord by a mechanical apparatus.
PMID:15629760
This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) of one or more vertebrae. This procedure can serve as sham condition for a spinal cord contusion study.
slaulede
2023-05-26T10:55:47Z
PMID:15629760
dorsal laminectomy
surgical removal of vertebral lamina
experimental_condition_ontology
XCO:0001043
laminectomy
XCO:0001043
This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) of one or more vertebrae. This procedure can serve as sham condition for a spinal cord contusion study.
PMID:15629760
https://www.mayoclinic.org/tests-procedures/laminectomy/about/pac-20394533
This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) of the ninth thoracic vertebra.
slaulede
2023-05-26T11:29:44Z
PMID:15629760
surgical removal of the lamina of the ninth thoracic vertebra
experimental_condition_ontology
XCO:0001044
T9 laminectomy
XCO:0001044
This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) of the ninth thoracic vertebra.
PMID:15629760
https://www.mayoclinic.org/tests-procedures/laminectomy/about/pac-20394533
This is any condition in which the main influencing factor is Walker 256, a rat mammary gland carcinoma cell line.
slaulede
2023-05-26T12:12:33Z
Cellosaurus:CVCL_3537
PMID:32209134
LLC-WRC 256 cells
W256 cells
experimental_condition_ontology
XCO:0001045
Walker 256 cells
XCO:0001045
This is any condition in which the main influencing factor is Walker 256, a rat mammary gland carcinoma cell line.
https://www.atcc.org/products/ccl-38
https://www.merriam-webster.com
This is any condition in which the main influencing factor is a Dnmt3a gapmer (Dnmt3a-targeting antisense oligonucleotide). Gapmers are mRNA-targeting, short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence.
slaulede
2023-06-01T15:19:05Z
PMID:30354815
DNA methyltransferase 3 alpha GapmeR
DNA methyltransferase 3 alpha gapmer antisense oligonucleotide
Dnmt3a GapmeR
experimental_condition_ontology
XCO:0001046
Dnmt3a gapmer antisense oligonucleotide
XCO:0001046
This is any condition in which the main influencing factor is a Dnmt3a gapmer (Dnmt3a-targeting antisense oligonucleotide). Gapmers are mRNA-targeting, short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence.
https://en.wikipedia.org/wiki/Gapmer
This is any condition in which the main influencing factor is a Tet3 gapmer (Tet3-targeting antisense oligonucleotide). Gapmers are mRNA-targeting, short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence.
slaulede
2023-06-01T15:28:16Z
PMID:30354815
Tet3 GapmeR
tet methylcytosine dioxygenase 3 GapmeR
tet methylcytosine dioxygenase 3 gapmer antisense oligonucleotide
experimental_condition_ontology
XCO:0001047
Tet3 gapmer antisense oligonucleotide
XCO:0001047
This is any condition in which the main influencing factor is a Tet3 gapmer (Tet3-targeting antisense oligonucleotide). Gapmers are mRNA-targeting, short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence.
https://en.wikipedia.org/wiki/Gapmer
This is any condition in which the main influencing factor is a negative control gapmer. A negative control gapmer is a gapmer with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental gapmer used.
slaulede
2023-06-01T15:36:36Z
PMID:30354815
SCR GapmeR
control GapmeR
scrambled GapmeR
scrambled GapmeR antisense oligonucleotide
experimental_condition_ontology
XCO:0001048
scrambled gapmer antisense oligonucleotide
XCO:0001048
This is any condition in which the main influencing factor is a negative control gapmer. A negative control gapmer is a gapmer with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental gapmer used.
PMID:30354815
https://en.wikipedia.org/wiki/Gapmer
This is any condition in which the main influencing factor is nicotine, a highly toxic alkaloid. Nicotine is a racemate composed of equimolar amounts of (R)- and (S)-nicotine. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission.
slaulede
2023-06-01T17:01:56Z
PMID:23874651
(R,S)-nicotine
(RS)-nicotine
rac-3-(1-methylpyrrolidin-2-yl)pyridine
experimental_condition_ontology
XCO:0001049
nicotine
XCO:0001049
This is any condition in which the main influencing factor is nicotine, a highly toxic alkaloid. Nicotine is a racemate composed of equimolar amounts of (R)- and (S)-nicotine. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission.
CHEBI:18723
MESH:D009538
This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) from both the eighth and the ninth thoracic vertebrae.
slaulede
2023-06-02T14:15:42Z
PMID:26546062
surgical removal of the lamina of the eighth and ninth thoracic vertebrae
experimental_condition_ontology
XCO:0001050
T8/T9 laminectomy
XCO:0001050
This is any condition in which the main influencing factor is surgical removal of the lamina (dorsal part of vertebra) from both the eighth and the ninth thoracic vertebrae.
PMID:26546062
https://www.mayoclinic.org/tests-procedures/laminectomy/about/pac-20394533
This is any condition in which the main influencing factor is a solid diet in which the amount of soy protein isolate, usually containing 85%–90% protein (dry basis), is maintained at a specified level. Soy protein isolates (SPI) are prepared by separating the fibers and insoluble carbohydrates from soy protein concentrate.
slaulede
2023-06-06T15:19:14Z
controlled SPI content diet
experimental_condition_ontology
XCO:0001051
controlled soy protein isolate content diet
XCO:0001051
This is any condition in which the main influencing factor is a solid diet in which the amount of soy protein isolate, usually containing 85%–90% protein (dry basis), is maintained at a specified level. Soy protein isolates (SPI) are prepared by separating the fibers and insoluble carbohydrates from soy protein concentrate.
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/soy-protein-isolate
This is any condition in which the main influencing factor is a 2'-deoxyribonucleoside that has formula C8H12N4O4. 5-aza-2′-deoxycytidine is a chemotherapeutic pyrimidine nucleoside analogue that integrates into cellular DNA and inhibits the action of DNA methyltransferases.
slaulede
2023-06-19T13:59:50Z
PMID:37288607
2'-Deoxy-5-azacytidine
4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
5-AzaD
5AzadC
Dacogen
decitabine
experimental_condition_ontology
XCO:0001052
5-aza-2′-deoxycytidine
XCO:0001052
This is any condition in which the main influencing factor is a 2'-deoxyribonucleoside that has formula C8H12N4O4. 5-aza-2′-deoxycytidine is a chemotherapeutic pyrimidine nucleoside analogue that integrates into cellular DNA and inhibits the action of DNA methyltransferases.
CID:451668
https://go.drugbank.com/drugs/DB01262
This is any condition in which the main influencing factor is closure of a wound, body parts, or anatomical orifices by the use of sutures, staples, or surgical adhesive/sealant.
slaulede
2023-06-20T15:13:05Z
GSE72787
surgical gluing
surgical stapling
surgical suturing
experimental_condition_ontology
XCO:0001053
surgical closure
XCO:0001053
This is any condition in which the main influencing factor is closure of a wound, body parts, or anatomical orifices by the use of sutures, staples, or surgical adhesive/sealant.
https://www.merriam-webster.com
https://www.sciencedirect.com/topics/medicine-and-dentistry/surgical-glue
This is any condition in which the main influencing factor is Qingda granule, derived from Qingxuan Jiangya Decoction (QXJYD), which has been in usage for a long time as a traditional Chinese medicine formula.
slaulede
2023-06-20T16:42:57Z
GSE144548
QDG
Qingda granules
experimental_condition_ontology
XCO:0001054
Qingda granule
XCO:0001054
This is any condition in which the main influencing factor is Qingda granule, derived from Qingxuan Jiangya Decoction (QXJYD), which has been in usage for a long time as a traditional Chinese medicine formula.
PMID:32199989
This is any condition in which the main influencing factor is luteolin, a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. Luteolin is a common flavonoid abundantly present in several plant products, including broccoli, pepper, thyme, and celery.
slaulede
2023-06-22T14:33:16Z
CHEBI:15864
MESH:D047311
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
3',4',5,7-Tetrahydroxyflavone
experimental_condition_ontology
XCO:0001055
luteolin
XCO:0001055
This is any condition in which the main influencing factor is luteolin, a tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers. Luteolin is a common flavonoid abundantly present in several plant products, including broccoli, pepper, thyme, and celery.
CHEBI:15864
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/luteolin
This is any condition in which the main influencing factor is methylglyoxal, a 2-oxo aldehyde derived from propanal. Methylglyoxal is an organic compound used often as a reagent in organic synthesis, as a flavoring agent, in tanning and as an experimental antidepressant. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
slaulede
2023-06-22T14:51:02Z
GSE119482
2-Oxopropanal
MGO
pyruvaldehyde
experimental_condition_ontology
XCO:0001056
methylglyoxal
XCO:0001056
This is any condition in which the main influencing factor is methylglyoxal, a 2-oxo aldehyde derived from propanal. Methylglyoxal is an organic compound used often as a reagent in organic synthesis, as a flavoring agent, in tanning and as an experimental antidepressant. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
CHEBI:17158
MESH:D011765
This is any condition in which the main influencing factor is corticosterone, a 21-carbon adrenocortical steroid hormone that has modest but significant activities as both a mineralocorticoid and a glucocorticoid.
slaulede
2023-06-23T14:29:08Z
CHEBI:16827
11beta,21-dihydroxypregn-4-ene-3,20-dione
experimental_condition_ontology
XCO:0001057
corticosterone
XCO:0001057
This is any condition in which the main influencing factor is corticosterone, a 21-carbon adrenocortical steroid hormone that has modest but significant activities as both a mineralocorticoid and a glucocorticoid.
ISBN:978-1455756438
MESH:D003345
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of corticosterone in which the amount of corticosterone consumed is maintained at a specified level.
slaulede
2023-06-23T14:40:29Z
CHEBI:16827
experimental_condition_ontology
XCO:0001058
controlled corticosterone content drinking water
XCO:0001058
This is an experimental condition in which the main influencing factor is a drink made up of water and a specified amount of corticosterone in which the amount of corticosterone consumed is maintained at a specified level.
MESH:D003345
https://www.merriam-webster.com
This is an experimental condition in which the main influencing factor is a drink made up of saline (0.9% sodium chloride solution) and a specified amount of one or more solutes.
slaulede
2023-06-23T14:54:26Z
PMID:30364965
controlled content 0.9% sodium chloride drink
controlled content drinking saline
controlled content normal saline drink
experimental_condition_ontology
XCO:0001059
controlled content saline drink
XCO:0001059
This is an experimental condition in which the main influencing factor is a drink made up of saline (0.9% sodium chloride solution) and a specified amount of one or more solutes.
ISBN:978-1455756438
https://www.merriam-webster.com
This is an experimental condition in which the main influencing factor is a drink made up of normal saline (0.9% sodium chloride) and a specified amount of corticosterone in which the amount of corticosterone consumed is maintained at a specified level.
slaulede
2023-06-23T15:03:59Z
PMID:30364965
controlled corticosterone content 0.9% sodium chloride drink
controlled corticosterone content normal saline drink
experimental_condition_ontology
XCO:0001060
controlled corticosterone content saline drink
XCO:0001060
This is an experimental condition in which the main influencing factor is a drink made up of normal saline (0.9% sodium chloride) and a specified amount of corticosterone in which the amount of corticosterone consumed is maintained at a specified level.
ISBN:978-1455756438
https://www.merriam-webster.com
This is any condition in which the main influencing factor is an oligosaccharide, a compound in which a small number of monosaccharide units (2-10) are joined by alpha- or beta-glycosidic linkages.
slaulede
2023-06-23T15:27:30Z
CHEBI:50699
MESH:D009844
oligosaccharides
experimental_condition_ontology
XCO:0001061
oligosaccharide
XCO:0001061
This is any condition in which the main influencing factor is an oligosaccharide, a compound in which a small number of monosaccharide units (2-10) are joined by alpha- or beta-glycosidic linkages.
ISBN:978-1455756438
MESH:D009844
This is any condition in which the main influencing factor is 2-hydroxypropyl-β-cyclodextrin, a hydroxypropyl-substituted heptasaccharide made up of a ring of seven glucose subunits joined by α-1,4 glycosidic bonds.
slaulede
2023-06-23T15:43:12Z
CHEBI:495055
MESH:C031215
2 Hydroxylpropyl beta cyclodextrin
2-Hydroxylpropyl-beta-cyclodextrin
HPβCD
HP-beta-CD
experimental_condition_ontology
XCO:0001062
2-hydroxypropyl-β-cyclodextrin
XCO:0001062
This is any condition in which the main influencing factor is 2-hydroxypropyl-β-cyclodextrin, a hydroxypropyl-substituted heptasaccharide made up of a ring of seven glucose subunits joined by α-1,4 glycosidic bonds.
https://en.wikipedia.org/wiki/Cyclodextrin
This is any condition in which the main influencing factor is the surgical excision of the pineal body, a midline, cone-like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures.
slaulede
2023-06-26T17:12:25Z
experimental_condition_ontology
XCO:0001063
pinealectomy
XCO:0001063
This is any condition in which the main influencing factor is the surgical excision of the pineal body, a midline, cone-like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures.
UBERON:0001905
https://www.merriam-webster.com
This is any condition in which the main influencing factor is a 5/6 nephrectomy, which is an experimental procedure performed to produce an animal model of chronic kidney disease in rodents. Typically, the right kidney is removed and the poles of the left kidney are removed to produce a total renal system which is 1/6 of original capacity.
slaulede
2023-06-26T18:07:22Z
PMID:28760335
5/6 Nx
5/6 nephrectomy
five-sixths partial nephrectomy
subtotal 5/6 nephrectomy
subtotal nephrectomy
experimental_condition_ontology
XCO:0001064
5/6 nephrectomy
XCO:0001064
This is any condition in which the main influencing factor is a 5/6 nephrectomy, which is an experimental procedure performed to produce an animal model of chronic kidney disease in rodents. Typically, the right kidney is removed and the poles of the left kidney are removed to produce a total renal system which is 1/6 of original capacity.
ISBN:978-1455756438
PMID:32001792
This is any condition in which the main influencing factor is a control locked nucleic acid (LNA)–modified oligonucleotide with a non-specific scrambled sequence. A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA), and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon. LNAs provide structural stability and nuclease resistance to the oligonucleotide.
slaulede
2023-06-27T13:16:05Z
PMID:28760335
scrambled control BNA oligonucleotide
scrambled control LNA oligonucleotide
scrambled control locked nucleic acid oligonucleotide
experimental_condition_ontology
XCO:0001065
scrambled control LNA-modified oligonucleotide
XCO:0001065
This is any condition in which the main influencing factor is a control locked nucleic acid (LNA)–modified oligonucleotide with a non-specific scrambled sequence. A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA), and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon. LNAs provide structural stability and nuclease resistance to the oligonucleotide.
https://en.wikipedia.org/wiki/Locked_nucleic_acid
https://www.idtdna.com/pages/technology/custom-dna-rna/locked-nucleic-acids
This is any condition in which the main influencing factor is a control locked nucleic acid (LNA)–modified oligonucleotide with an anti–rat miR-21-5p sequence. A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA), and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon. LNAs provide structural stability and nuclease resistance to the oligonucleotide.
slaulede
2023-06-27T14:04:55Z
PMID:28760335
BNA-modified anti–rno-miR-21-5p oligonucleotide
LNA-modified anti-microRNA-21-5p oligonucleotide
experimental_condition_ontology
XCO:0001066
LNA-modified anti–rno-miR-21-5p oligonucleotide
XCO:0001066
This is any condition in which the main influencing factor is a control locked nucleic acid (LNA)–modified oligonucleotide with an anti–rat miR-21-5p sequence. A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA), and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon. LNAs provide structural stability and nuclease resistance to the oligonucleotide.
https://en.wikipedia.org/wiki/Locked_nucleic_acid
https://www.idtdna.com/pages/technology/custom-dna-rna/locked-nucleic-acids
This is any condition in which the main influencing factor is nitroglycerin, a volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. It is also sometimes used for tocolysis.
slaulede
2023-07-06T16:25:28Z
CHEBI:28787
1,2,3-trinitrooxypropane
experimental_condition_ontology
XCO:0001067
nitroglycerin
XCO:0001067
This is any condition in which the main influencing factor is nitroglycerin, a volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. It is also sometimes used for tocolysis.
MESH:D005996
This is any condition in which the main influencing factor is sleep, the natural, easily reversible periodic state of many living things that is marked by the absence of wakefulness and by the loss of consciousness of one's surroundings, is accompanied by a typical body posture (such as lying down with the eyes closed), the occurrence of dreaming, and changes in brain activity and physiological functioning.
slaulede
2023-07-17T17:37:42Z
napping
slumber
snoozing
experimental_condition_ontology
XCO:0001068
sleep
XCO:0001068
This is any condition in which the main influencing factor is sleep, the natural, easily reversible periodic state of many living things that is marked by the absence of wakefulness and by the loss of consciousness of one's surroundings, is accompanied by a typical body posture (such as lying down with the eyes closed), the occurrence of dreaming, and changes in brain activity and physiological functioning.
https://www.merriam-webster.com
This is any condition in which the main influencing factor is sleep restriction, a state caused by inadequate quantity or quality of sleep, including voluntary or involuntary sleeplessness and circadian rhythm sleep. Sleep restriction may be caused by stress, school or job requirements, poor sleeping habits, or an experimentally arranged situation.
slaulede
2023-07-17T17:58:29Z
PMID:32040351
sleep deprivation
experimental_condition_ontology
insomnia
XCO:0001069
sleep restriction
XCO:0001069
This is any condition in which the main influencing factor is sleep restriction, a state caused by inadequate quantity or quality of sleep, including voluntary or involuntary sleeplessness and circadian rhythm sleep. Sleep restriction may be caused by stress, school or job requirements, poor sleeping habits, or an experimentally arranged situation.
https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/sleep-deprivation
This is any condition in which the main influencing factor is papain, a cysteine protease present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis). In addition to experimental uses in biology research, it has wide ranging commercial applications in the leather, cosmetic, textiles, detergents, food and pharmaceutical industries.
slaulede
2023-07-18T14:25:07Z
EC:3.4.22.2
MESH:D010206
papaya proteinase 1
experimental_condition_ontology
XCO:0001070
papain
XCO:0001070
This is any condition in which the main influencing factor is papain, a cysteine protease present in papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis). In addition to experimental uses in biology research, it has wide ranging commercial applications in the leather, cosmetic, textiles, detergents, food and pharmaceutical industries.
https://en.wikipedia.org/wiki/Papain
This is any condition in which the main influencing factor is L-cysteine, an optically active form of cysteine having the L-configuration at the alpha-carbon. It is a thiol-containing non-essential amino acid that is oxidized to form cystine.
slaulede
2023-07-18T16:58:46Z
PMID:31950348
half-cystine
experimental_condition_ontology
XCO:0001071
L-cysteine
XCO:0001071
This is any condition in which the main influencing factor is L-cysteine, an optically active form of cysteine having the L-configuration at the alpha-carbon. It is a thiol-containing non-essential amino acid that is oxidized to form cystine.
CHEBI:17561
MESH:D003545
This is any condition in which the main influencing factor is the soluble transforming growth factor-beta receptor 2 gene (sTGFβR2) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
slaulede
2023-07-20T14:03:21Z
gene transfer of the sTGFβR2 gene using an adenoviral vector
gene transfer of the soluble transforming growth factor-beta receptor 2 gene using a adenoviral vector
transduction of sTGFβR2 using an adenoviral vector
transduction of sTGFβR2 using an adenovirus vector
experimental_condition_ontology
XCO:0001072
gene transfer of the sTGFβR2 gene using an adenovirus vector
XCO:0001072
This is any condition in which the main influencing factor is the soluble transforming growth factor-beta receptor 2 gene (sTGFβR2) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
PMID:31950348
This is any condition in which the main influencing factor is the klotho gene (KL) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
slaulede
2023-07-20T14:15:01Z
gene transfer of the KL gene using an adenoviral vector
gene transfer of the alpha klotho gene using a adenoviral vector
gene transfer of the klotho gene using a adenoviral vector
transduction of KL using an adenoviral vector
transduction of KL using an adenovirus vector
experimental_condition_ontology
XCO:0001073
gene transfer of the KL gene using an adenovirus vector
XCO:0001073
This is any condition in which the main influencing factor is the klotho gene (KL) which has been (transiently or stably) transferred into a cell or organism using an adenovirus carrier in order to induce synthesis of that gene's product in the recipient cell or organism.
PMID:31950348
This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of one or both ureters. Ureters are the muscular ducts that propel urine from the kidneys to the urinary bladder.
slaulede
2023-08-01T13:28:25Z
experimental_condition_ontology
UO
ureteral obstruction
XCO:0001074
ureter ligation
XCO:0001074
This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of one or both ureters. Ureters are the muscular ducts that propel urine from the kidneys to the urinary bladder.
ISBN:978-1455756438
UBERON:0000056
This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of one ureter. Unilateral ureter ligation is used in experimental animals to create a model of unilateral ureteral obstruction and renal fibrosis.
slaulede
2023-08-01T14:00:10Z
experimental_condition_ontology
UUO
unilateral ureteral obstruction
XCO:0001075
unilateral ureter ligation
XCO:0001075
This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of one ureter. Unilateral ureter ligation is used in experimental animals to create a model of unilateral ureteral obstruction and renal fibrosis.
ISBN:978-1455756438
PMID:28912732
This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of both ureters. Bilateral ureter ligation (BUL) is used in experimental animals to create a model of renal failure.
slaulede
2023-08-01T14:15:15Z
BUL
experimental_condition_ontology
BUO
bilateral ureteral obstruction
XCO:0001076
bilateral ureter ligation
XCO:0001076
This is a condition in which the main influencing factor is an experimental surgical procedure causing blockage of both ureters. Bilateral ureter ligation (BUL) is used in experimental animals to create a model of renal failure.
ISBN:978-1455756438
PMID:20797570
This is any condition in which the main influencing factor is bisphenol F, an organic compound with the chemical formula (HOC6H4)2CH2. It is structurally related to bisphenol A (BPA), a popular precursor for forming plastics, as both belong to the category of molecules known as bisphenols, which feature two phenol groups connected via a linking group.
slaulede
2023-08-08T16:49:17Z
CHEBI:34575
MESH:C008745
4,4′-Dihydroxydiphenylmethane
4,4′-Methylenediphenol
4,4'-bisphenol F
4-(4-hydroxybenzyl)phenol
BPF
experimental_condition_ontology
XCO:0001077
bisphenol F
XCO:0001077
This is any condition in which the main influencing factor is bisphenol F, an organic compound with the chemical formula (HOC6H4)2CH2. It is structurally related to bisphenol A (BPA), a popular precursor for forming plastics, as both belong to the category of molecules known as bisphenols, which feature two phenol groups connected via a linking group.
https://en.wikipedia.org/wiki/Bisphenol_F
This is any condition in which the main influencing factor is bisphenol F in a drink made up of water and a specified amount of bisphenol F consumed by an organism as part of an experiment. Bisphenol F is an organic compound with the chemical formula (HOC6H4)2CH2.
slaulede
2023-08-08T17:13:41Z
CHEBI:34575
MESH:C008745
controlled 4,4′-Dihydroxydiphenylmethane content drinking water
controlled 4,4′-Methylenediphenol content drinking water
controlled BPF content drinking water
experimental_condition_ontology
XCO:0001078
controlled bisphenol F content drinking water
XCO:0001078
This is any condition in which the main influencing factor is bisphenol F in a drink made up of water and a specified amount of bisphenol F consumed by an organism as part of an experiment. Bisphenol F is an organic compound with the chemical formula (HOC6H4)2CH2.
https://en.wikipedia.org/wiki/Bisphenol_F
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is adenine, the parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6. Adenine is one of the five constituent bases of nucleic acids.The shape of adenine is complementary to either thymine in DNA or uracil in RNA.
slaulede
2023-09-14T15:58:46Z
MESH:D000225
1H-Purin-6-amine
6-Aminopurine
9H-purin-6-amine
experimental_condition_ontology
XCO:0001079
adenine
XCO:0001079
This is any condition in which the main influencing factor is adenine, the parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6. Adenine is one of the five constituent bases of nucleic acids.The shape of adenine is complementary to either thymine in DNA or uracil in RNA.
CHEBI:16708
https://en.wikipedia.org/wiki/Adenine
This is any condition in which the main influencing factor is monoiodoacetate, a haloacetate(1-) resulting from the deprotonation of the carboxy group of iadoacetic acid.
slaulede
2023-10-02T13:55:23Z
MIA
iodoacetate
experimental_condition_ontology
XCO:0001080
monoiodoacetate
XCO:0001080
This is any condition in which the main influencing factor is monoiodoacetate, a haloacetate(1-) resulting from the deprotonation of the carboxy group of iadoacetic acid.
CHEBI:23123
This is any condition in which the main influencing factor is SBFI-103, a selective FABP5 inhibitor. It is an experimental drug for treatment of cancer and osteoarthritis.
slaulede
2023-10-02T14:40:38Z
CAS:2132990-98-6
9-Fluorenylmethyl a-3-hydroxycarbonyl-2,4-di(2-methoxylphenyl)-cyclobutane-1-carboxylate
FABP5-IN-1
SB-FI-103
alpha-SBFI-103
experimental_condition_ontology
XCO:0001081
SBFI-103
XCO:0001081
This is any condition in which the main influencing factor is SBFI-103, a selective FABP5 inhibitor. It is an experimental drug for treatment of cancer and osteoarthritis.
PMID:35650684
https://synapse.patsnap.com/drug/8addafe1559d4e20a32638b36f0515ec
This is any condition in which the major influencing factor is the fibrillar collagen which comprises the main component of cartilage and is also found in the vitreous humor of the eye. Collagens are a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility.
slaulede
2023-10-03T13:13:21Z
Bos taurus type II collagen
cattle type II collagen
experimental_condition_ontology
XCO:0001082
bovine type II collagen
XCO:0001082
This is any condition in which the major influencing factor is the fibrillar collagen which comprises the main component of cartilage and is also found in the vitreous humor of the eye. Collagens are a family of extracellular, closely related proteins occurring as a major component of connective tissue, giving it strength and flexibility.
ISBN:978-1455756438
http://en.wikipedia.org/wiki/Collagen
This is any condition in which the main influencing factor is imperatorin, a member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
slaulede
2023-10-03T13:24:53Z
CAS:482-44-0
MESH:C031534
PMID:32392637
9-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
IMP
experimental_condition_ontology
XCO:0001083
imperatorin
XCO:0001083
This is any condition in which the main influencing factor is imperatorin, a member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
CHEBI:5885
This is any condition in which the main influencing factor is beta-Sitosterol, one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. It is a white, waxy powder with a characteristic odor, and is one of the components of the food additive E499.
slaulede
2023-10-03T14:44:34Z
CAS:83-46-5
PMID:32392637
beta-sitosterol
experimental_condition_ontology
XCO:0001084
beta-Sitosterol
XCO:0001084
This is any condition in which the main influencing factor is beta-Sitosterol, one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. It is a white, waxy powder with a characteristic odor, and is one of the components of the food additive E499.
https://en.wikipedia.org/wiki/Beta-Sitosterol
This is a condition induced by an experimental surgical procedure involving disruption of CSF circulation in the spinal cord. This artificial compression is intended to mimic the human disease canalicular syringomyelia.
slaulederkind
2023-10-27T17:01:49Z
experimental extradural spinal cord compression
experimental_condition_ontology
XCO:0001085
experimental epidural spinal cord compression
XCO:0001085
This is a condition induced by an experimental surgical procedure involving disruption of CSF circulation in the spinal cord. This artificial compression is intended to mimic the human disease canalicular syringomyelia.
PMID:37275526
This is any condition in which the main influencing factor is TRV023, an angiotensin analogue which is a beta-arrestin selective signaling AGTR1 agonist. It is a biased ligand because it does not affect G-protein signaling by AGTR1.
slaulederkind
2023-10-31T13:11:19Z
Sar-Arg-Val-Tyr-Lys-His-Pro-Ala-OH
TRV
experimental_condition_ontology
XCO:0001086
TRV023
XCO:0001086
This is any condition in which the main influencing factor is TRV023, an angiotensin analogue which is a beta-arrestin selective signaling AGTR1 agonist. It is a biased ligand because it does not affect G-protein signaling by AGTR1.
PMID:32259102
PMID:34201646
This is any condition in which the main influencing factor is limited bedding and nesting, a housing condition designed to create a model of early life adversity. The minimum bedding/nesting may be as little as a paper towel in a plain, unadorned cage.
slaulederkind
2023-10-31T13:46:58Z
LBN
limited bedding and nesting model
limited bedding/nesting model
experimental_condition_ontology
XCO:0001087
limited bedding and nesting
XCO:0001087
This is any condition in which the main influencing factor is limited bedding and nesting, a housing condition designed to create a model of early life adversity. The minimum bedding/nesting may be as little as a paper towel in a plain, unadorned cage.
PMID:35102257
This is any condition in which the main influencing factor is cefuroxime, a broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. Cefuroxime has been proposed for treatment of infections of gram-negative organisms, gram-positive organisms, gonorrhea, and haemophilus.
slaulederkind
2023-11-02T12:28:19Z
3-[(carbamoyloxy)methyl]-7beta-[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetamido]-3,4-didehydrocepham-4-carboxylic acid
CHEBI:3515
CID:5479529
experimental_condition_ontology
XCO:0001088
cefuroxime
XCO:0001088
This is any condition in which the main influencing factor is cefuroxime, a broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. Cefuroxime has been proposed for treatment of infections of gram-negative organisms, gram-positive organisms, gonorrhea, and haemophilus.
MESH:D002444
This is any condition in which the main influencing factor is a hirudin, a single-chain polypeptide of about 65 amino acids (7 kDa) found in leech saliva, that has a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Hirudins, both natural and synthetic, are inhibitors of thrombin.
slaulederkind
2023-11-02T13:01:47Z
hirudins
MESH:C074619
MESH:C083544
PMID:34621173
experimental_condition_ontology
XCO:0001089
hirudin
XCO:0001089
This is any condition in which the main influencing factor is a hirudin, a single-chain polypeptide of about 65 amino acids (7 kDa) found in leech saliva, that has a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Hirudins, both natural and synthetic, are inhibitors of thrombin.
MESH:D006629
This is any condition in which the main influencing factor is an anticoagulant, a substance that hinders the clotting of blood.
slaulederkind
2023-11-02T13:12:35Z
CHEBI:50249
MESH:D000925
PMID:34621173
experimental_condition_ontology
XCO:0001090
anticoagulant
XCO:0001090
This is any condition in which the main influencing factor is an anticoagulant, a substance that hinders the clotting of blood.
ISBN:978-1455756438
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is experimental spinal cord injury, a penetrating or non-penetrating injury to the spinal cord resulting from experimentally controlled trauma.
slaulederkind
2023-11-02T13:45:26Z
DOID:9000039
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE149657
experimental_condition_ontology
XCO:0001091
experimental spinal cord injury
XCO:0001091
This is any condition in which the main influencing factor is experimental spinal cord injury, a penetrating or non-penetrating injury to the spinal cord resulting from experimentally controlled trauma.
MESH:D013119
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is an experimentally controlled sciatic nerve crush, which is used as a model of sciatic neuropathy, Wallerian degeneration, and axonal regeneration.
slaulederkind
2023-11-02T13:57:14Z
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE149657
experimental_condition_ontology
XCO:0001092
sciatic nerve crush
XCO:0001092
This is any condition in which the main influencing factor is an experimentally controlled sciatic nerve crush, which is used as a model of sciatic neuropathy, Wallerian degeneration, and axonal regeneration.
PMID:35768768
This is any condition in which the main influencing factor is epigallocatechin-3-gallate, a gallate ester which is an antimutagen found in tea (Camellia sinensis) with the highest concentration in green tea.
slaulederkind
2023-11-03T14:46:21Z
CHEBI:4806
(-)-epigallocatechin 3-gallate
EGCG
epigallocatechin gallate
experimental_condition_ontology
XCO:0001093
epigallocatechin-3-gallate
XCO:0001093
This is any condition in which the main influencing factor is epigallocatechin-3-gallate, a gallate ester which is an antimutagen found in tea (Camellia sinensis) with the highest concentration in green tea.
MESH:C045651
This is any condition in which the main influencing factor is CFT-1, a green tea variety called Camellia sinensis (L.) O. Kuntze cv. CFT‐1, which is rich in EGCG (antimutagen epigallocatechin-3-gallate).
slaulederkind
2023-11-03T15:30:13Z
CFT‐1 green tea infusion
CFT-1
Camellia sinensis (L.) O. Kuntze cv. CFT‐1
Camellia sinensis CV.CFT‐1 tea
EGCG‐rich tea
experimental_condition_ontology
XCO:0001094
CFT‐1 tea infusion
XCO:0001094
This is any condition in which the main influencing factor is CFT-1, a green tea variety called Camellia sinensis (L.) O. Kuntze cv. CFT‐1, which is rich in EGCG (antimutagen epigallocatechin-3-gallate).
PMID:31428352
https://en.wikipedia.org/wiki/Camellia_sinensis
This is any condition in which the main influencing factor is FYT, a common green tea variety called Camellia sinensis (L.) O. Kuntze cv. Fuyun6.
slaulederkind
2023-11-03T15:57:46Z
Camellia sinensis (L.) O. Kuntze cv. FYT
Camellia sinensis (L.) O. Kuntze cv. Fuyun6
Camellia sinensis CV.FYT tea
FYT
FYT green tea infusion
Fuyun6 green tea
experimental_condition_ontology
XCO:0001095
FYT tea infusion
XCO:0001095
This is any condition in which the main influencing factor is FYT, a common green tea variety called Camellia sinensis (L.) O. Kuntze cv. Fuyun6.
PMID:31428352
https://en.wikipedia.org/wiki/Camellia_sinensis
This is any condition in which the main influencing factor is sodium taurocholate, the sodium salt of taurocholic acid. Sodium taurocholate is the chief ingredient of the bile of carnivorous animals. It is used experimentally to induce severe acute pancreatitis in laboratory animals.
slaulederkind
2023-11-06T16:23:56Z
CAS:145-42-6
CID:23666345
Taurocholate sodium salt
sodium 2-[(3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonate
experimental_condition_ontology
XCO:0001096
sodium taurocholate
XCO:0001096
This is any condition in which the main influencing factor is sodium taurocholate, the sodium salt of taurocholic acid. Sodium taurocholate is the chief ingredient of the bile of carnivorous animals. It is used experimentally to induce severe acute pancreatitis in laboratory animals.
MESH:D013656
PMID:35496266
This is any condition in which the main influencing factor is JZL184, an irreversible inhibitor of monoacylglycerol lipase (MAGL), the primary enzyme responsible for degrading the endocannabinoid 2-arachidonoylglycerol (2-AG).
slaulederkind
2023-11-06T16:56:32Z
CAS:1101854-58-3
CID:25021165
PMID:35496266
4-Nitrophenyl 4-[di(2H-1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate
experimental_condition_ontology
XCO:0001097
JZL184
XCO:0001097
This is any condition in which the main influencing factor is JZL184, an irreversible inhibitor of monoacylglycerol lipase (MAGL), the primary enzyme responsible for degrading the endocannabinoid 2-arachidonoylglycerol (2-AG).
https://en.wikipedia.org/wiki/JZL184
This is any condition in which the main influencing factor is crystalline silica. Silica is synonymous with silicon dioxide (SiO2) and commonly found in nature as sand. Silica exists mainly as crystalline silica (mostly in the form of quartz).
slaulederkind
2023-11-09T10:09:39Z
CHEBI:30563
CHEBI:46727
MESH:D011791
MESH:D012822
respirable crystalline silica
experimental_condition_ontology
XCO:0001098
crystalline silica
XCO:0001098
This is any condition in which the main influencing factor is crystalline silica. Silica is synonymous with silicon dioxide (SiO2) and commonly found in nature as sand. Silica exists mainly as crystalline silica (mostly in the form of quartz).
https://safesilica.eu/crystalline-silica-the-science/
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is respirable crystalline silica, which is breathable silica dust. The level of crystalline silica in the air surrounding an organism or breathed by an organism is determined by environmental conditions, work conditions, or controlled as part of an experiment.
slaulederkind
2023-11-09T10:36:46Z
CHEBI:30563
CHEBI:46727
MESH:D011791
MESH:D012822
respirable crystalline silica content
experimental_condition_ontology
XCO:0001099
air crystalline silica content
XCO:0001099
This is any condition in which the main influencing factor is respirable crystalline silica, which is breathable silica dust. The level of crystalline silica in the air surrounding an organism or breathed by an organism is determined by environmental conditions, work conditions, or controlled as part of an experiment.
https://leadlab.com/what-is-crystalline-silica-testing/
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is the use of manual or mechanical, non-surgical means to aid a patient or experimental animal in performing some biological activity for the purpose of examination, collection of samples, drug administration, therapy, or experimental manipulation. This may or may not require the use of tools or devices.
slaulederkind
2023-11-09T13:03:47Z
PMID:35627209
experimental_condition_ontology
XCO:0001100
physical manipulation
XCO:0001100
This is any condition in which the main influencing factor is the use of manual or mechanical, non-surgical means to aid a patient or experimental animal in performing some biological activity for the purpose of examination, collection of samples, drug administration, therapy, or experimental manipulation. This may or may not require the use of tools or devices.
https://anti-doping.government.bg/en/m2-khimicheski-i-fizicheski-manipulatsii_p58.html
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is urinary catheterization, the insertion of a tune through the urethra into the bladder to allow urine to drain from the bladder for collection or to allow injection of some substance.
slaulederkind
2023-11-09T13:23:26Z
urethra catheterization
urethral catheterization
Foley catheter
Robinson catheter
experimental_condition_ontology
XCO:0001101
urinary catheterization
XCO:0001101
This is any condition in which the main influencing factor is urinary catheterization, the insertion of a tune through the urethra into the bladder to allow urine to drain from the bladder for collection or to allow injection of some substance.
ISBN-13:978-1455756438
https://en.wikipedia.org/wiki/Urinary_catheterization
This is any condition in which the main influencing factor is serotonin hydrochloride, the hydrochloride form of a primary amino compound (serotonin) that is the 5-hydroxy derivative of tryptamine.
slaulederkind
2023-11-09T14:26:08Z
CHEBI:181195
3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride
5-HT hydrochloride
5-Hydroxytryptamine hydrochloride
Serotonin HCl
experimental_condition_ontology
XCO:0001102
serotonin hydrochloride
XCO:0001102
This is any condition in which the main influencing factor is serotonin hydrochloride, the hydrochloride form of a primary amino compound (serotonin) that is the 5-hydroxy derivative of tryptamine.
CHEBI:28790
This is any condition in which the main influencing factor is 17beta-estradiol 3-benzoate, the C17β benzoate ester of estradiol.
slaulederkind
2023-11-09T14:47:50Z
CHEBI:77006
β-estradiol 3-benzoate
(17beta)-17-hydroxyestra-1(10),2,4-trien-3-yl benzoate
estradiol 3-benzoate
estradiol benzoate
experimental_condition_ontology
XCO:0001103
17beta-estradiol 3-benzoate
XCO:0001103
This is any condition in which the main influencing factor is 17beta-estradiol 3-benzoate, the C17β benzoate ester of estradiol.
CID:222757
This is any condition in which the main influencing factor is Q808, an experimental phthalazine tetrazole derivative being tested for effectiveness as an anti-inflammatory, anticonvulsant, and analgesic drug.
slaulederkind
2023-11-10T15:07:40Z
PMID:35831127
6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine
QUAN0808
experimental_condition_ontology
XCO:0001104
QUAN-0808
XCO:0001104
This is any condition in which the main influencing factor is Q808, an experimental phthalazine tetrazole derivative being tested for effectiveness as an anti-inflammatory, anticonvulsant, and analgesic drug.
ISBN-13:978-1455756438
PMID:23238472
This is any condition in which the main influencing factor is a controlled in situ ophthalmic condition, an experimental or medical condition in which the internal or external environment of the eye(s) is altered.
slaulederkind
2023-11-10T15:50:43Z
controlled in situ eye condition
experimental_condition_ontology
XCO:0001105
controlled in situ ophthalmic condition
XCO:0001105
This is any condition in which the main influencing factor is a controlled in situ ophthalmic condition, an experimental or medical condition in which the internal or external environment of the eye(s) is altered.
ISBN-13:978-1455756438
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is retinal reperfusion, the flow of blood to the retina being restored after a period of blood vessel occlusion occurring experimentally.
slaulederkind
2023-11-10T15:57:47Z
DOID:9001725
retina ischemia-reperfusion
retina ischemia/reperfusion
retinal ischemia-reperfusion
retinal reperfusion
experimental_condition_ontology
XCO:0001106
retinal reperfusion
XCO:0001106
This is any condition in which the main influencing factor is retinal reperfusion, the flow of blood to the retina being restored after a period of blood vessel occlusion occurring experimentally.
ISBN-13:978-1455756438
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is a polymer, any of a class of natural or synthetic substances composed of very large molecules, called macromolecules, which are multiples of simpler chemical units called monomers.
slaulederkind
2023-11-13T12:40:55Z
PMID:36693849
experimental_condition_ontology
XCO:0001107
polymer
XCO:0001107
This is any condition in which the main influencing factor is a polymer, any of a class of natural or synthetic substances composed of very large molecules, called macromolecules, which are multiples of simpler chemical units called monomers.
https://www.britannica.com/science/polymer
This is any condition in which the main influencing factor is alginate, a naturally occurring anionic polymer typically obtained from brown seaweed. It is used as a wound dressing to keep the wound area moist.
slaulederkind
2023-11-13T12:50:44Z
PMID:36693849
experimental_condition_ontology
XCO:0001108
alginate
XCO:0001108
This is any condition in which the main influencing factor is alginate, a naturally occurring anionic polymer typically obtained from brown seaweed. It is used as a wound dressing to keep the wound area moist.
PMID:22125349
This is any condition in which the main influencing factor is a glycosaminoglycan, any polysaccharide composed of repeating disaccharide units and containing a substantial proportion of amino monosaccharide residues. Glycosaminoglycans are constituents of mucoproteins, glycoproteins, and blood-group substances.
slaulederkind
2023-11-13T13:21:20Z
PMID:36693849
GAG
mucopolysaccharide
s-GAG
snail glycosaminoglycan
experimental_condition_ontology
XCO:0001109
glycosaminoglycan
XCO:0001109
This is any condition in which the main influencing factor is a glycosaminoglycan, any polysaccharide composed of repeating disaccharide units and containing a substantial proportion of amino monosaccharide residues. Glycosaminoglycans are constituents of mucoproteins, glycoproteins, and blood-group substances.
CHEBI:18085
https://www.merriam-webster.com/
https://www.ncbi.nlm.nih.gov/books/NBK544295/
This is any condition in which the main influencing factor is dried snail-mucus gel (SMG), a natural substance derived from mucus harvested from snails (Achatina fulica or Helix lucorum). The chemical composition of SMG includes a high percentage of heparin-like glycosaminoglycan.
slaulederkind
2023-11-13T14:10:33Z
PMID:36693849
dried SMG
dried snail-mucus gel
dried snail-mucus glue
experimental_condition_ontology
XCO:0001110
d-SMG
XCO:0001110
This is any condition in which the main influencing factor is dried snail-mucus gel (SMG), a natural substance derived from mucus harvested from snails (Achatina fulica or Helix lucorum). The chemical composition of SMG includes a high percentage of heparin-like glycosaminoglycan.
PMID:36693849
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is mercury dichloride, a mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, its use has markedly declined as less toxic alternatives have been developed.
slaulederkind
2023-11-14T09:45:49Z
MESH:D008627
PMID:32599119
HgCl2
Mercuric chloride
mercury(2+) chloride
experimental_condition_ontology
XCO:0001111
mercury dichloride
XCO:0001111
This is any condition in which the main influencing factor is mercury dichloride, a mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, its use has markedly declined as less toxic alternatives have been developed.
CHEBI:31823
This is any condition in which the main influencing factor is a nephrotoxic substance that causes injury to the kidney or damages its function.
slaulederkind
2023-11-14T13:26:51Z
CHEBI:50909
PMID:32599119
kidney toxicity-inducing chemical
nephrotoxic agent
nephrotoxicity-inducing chemical
renal toxicity-inducing chemical
experimental_condition_ontology
XCO:0001112
nephrotoxicant
XCO:0001112
This is any condition in which the main influencing factor is a nephrotoxic substance that causes injury to the kidney or damages its function.
ISBN-13:978-1455756438
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is folic acid, an N-acyl-amino acid that is a form of the water-soluble vitamin B9.
slaulederkind
2023-11-14T14:00:24Z
MESH:D005492
PMID:33375730
folicin
pteroylglutamic acid
vitamin B9
experimental_condition_ontology
folate
XCO:0001113
folic acid
XCO:0001113
This is any condition in which the main influencing factor is folic acid, an N-acyl-amino acid that is a form of the water-soluble vitamin B9.
CHEBI:27470
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is a controlled folic acid content diet, a solid diet in which the amount of folic acid is maintained at a specified level. Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9.
slaulederkind
2023-11-14T14:18:28Z
MESH:D005492
PMID:33375730
controlled pteroylglutamic acid content diet
controlled folicin content diet
controlled vitamin B9 content diet
experimental_condition_ontology
XCO:0001114
controlled folic acid content diet
XCO:0001114
This is any condition in which the main influencing factor is a controlled folic acid content diet, a solid diet in which the amount of folic acid is maintained at a specified level. Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9.
CHEBI:27470
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is (6S)-5-methyltetrahydrofolic acid, the primary biologically active form of folate (vitamin B9).
slaulederkind
2023-11-14T16:20:34Z
CHEBI:136009
CID:135398561
PMID:33375730
(6S)-5-MTHF
Levomefolic acid
N-[4-({[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
experimental_condition_ontology
XCO:0001115
(6S)-5-methyltetrahydrofolic acid
XCO:0001115
This is any condition in which the main influencing factor is (6S)-5-methyltetrahydrofolic acid, the primary biologically active form of folate (vitamin B9).
CHEBI:136009
https://en.wikipedia.org/wiki/Levomefolic_acid
This is any condition in which the main influencing factor is a controlled (6S)-5-methyltetrahydrofolic acid content diet, a solid diet in which the amount of (6S)-5-methyltetrahydrofolic acid is maintained at a specified level. (6S)-5-methyltetrahydrofolic acid is the primary biologically active form of folate (vitamin B9).
slaulederkind
2023-11-14T16:35:06Z
CHEBI:136009
PMID:33375730
controlled (6S)-5-MTHF content diet
controlled 5-MTHF content diet
experimental_condition_ontology
XCO:0001116
controlled (6S)-5-methyltetrahydrofolic acid content diet
XCO:0001116
This is any condition in which the main influencing factor is a controlled (6S)-5-methyltetrahydrofolic acid content diet, a solid diet in which the amount of (6S)-5-methyltetrahydrofolic acid is maintained at a specified level. (6S)-5-methyltetrahydrofolic acid is the primary biologically active form of folate (vitamin B9).
PMID:_35999905
https://en.wikipedia.org/wiki/Levomefolic_acid
This is any condition in which the main influencing factor is pefloxacin, a substituted quinolone that is an antibacterial agent and inhibitor of DNA biosynthesis.
slaulederkind
2023-11-14T17:41:45Z
MESH:D015366
1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
pefloxacinium
experimental_condition_ontology
XCO:0001117
pefloxacin
XCO:0001117
This is any condition in which the main influencing factor is pefloxacin, a substituted quinolone that is an antibacterial agent and inhibitor of DNA biosynthesis.
CHEBI:50199
This is any condition in which the main influencing factor is the use of a prosthetic device to generate a unilateral anterior crossbite in laboratory animals. A unilateral anterior crossbite is a specific type of dental malocclusion that creates temporomandibular joint osteoarthritis via biomechanical stress in the experimental subject or patient.
slaulederkind
2023-11-16T12:12:51Z
PMID:37919852
experimental UAC
experimental_condition_ontology
XCO:0001118
experimental unilateral anterior crossbite
XCO:0001118
This is any condition in which the main influencing factor is the use of a prosthetic device to generate a unilateral anterior crossbite in laboratory animals. A unilateral anterior crossbite is a specific type of dental malocclusion that creates temporomandibular joint osteoarthritis via biomechanical stress in the experimental subject or patient.
ISBN-13:978-1455756438
PMID:26746151
This is any condition in which the main influencing factor is deionized water, a form of purified water that is filtered through one or two tanks of ion-exchange resin which replaces cations with hydrogen (H+) ions and anions with hydroxyl (OH-) ions, leaving a mineral-free water.
slaulederkind
2023-11-16T13:38:37Z
pure water
PMID:32745584
deionized H2O
experimental_condition_ontology
XCO:0001119
deionized water
XCO:0001119
This is any condition in which the main influencing factor is deionized water, a form of purified water that is filtered through one or two tanks of ion-exchange resin which replaces cations with hydrogen (H+) ions and anions with hydroxyl (OH-) ions, leaving a mineral-free water.
https://www.merriam-webster.com/
https://www.waterdropfilter.com/blogs/water
This is any condition in which the main influencing factor is almorexant, an experimental drug developed to combat insomnia. Almorexant is a competitive, dual OX1 and OX2 receptor antagonist and selectively inhibits the functional consequences of OX1 and OX2 receptor activation, such as intracellular Ca2+ mobilization.
slaulederkind
2023-11-16T14:00:56Z
PMID:32066707
(2R)-2-[(1S)-6,7-dimethoxy-1-[2-[4-(triluoromethyl)phenyl]ethyl]-3,4-dihydro-1H-isoquinolin-2-yl]-N-methyl-2-phenylacetamide
ACT-078573
experimental_condition_ontology
XCO:0001120
almorexant
XCO:0001120
This is any condition in which the main influencing factor is almorexant, an experimental drug developed to combat insomnia. Almorexant is a competitive, dual OX1 and OX2 receptor antagonist and selectively inhibits the functional consequences of OX1 and OX2 receptor activation, such as intracellular Ca2+ mobilization.
https://en.wikipedia.org/wiki/Almorexant
This is any condition in which the main influencing factor is polyethylene glycol 400, a polymer composed of repeating ethyleneoxy units with an average molecular weight of 400. PEG 400 is a clear, colorless, liquid with low toxicity, affording wide use in a variety of pharmaceutical formulations.
slaulederkind
2023-11-16T14:17:21Z
CHEBI:46793
polyethylene glycol 400
experimental_condition_ontology
XCO:0001121
PEG 400
XCO:0001121
This is any condition in which the main influencing factor is polyethylene glycol 400, a polymer composed of repeating ethyleneoxy units with an average molecular weight of 400. PEG 400 is a clear, colorless, liquid with low toxicity, affording wide use in a variety of pharmaceutical formulations.
CHEBI:46793
https://en.wikipedia.org/wiki/PEG_400
This is any condition in which the main influencing factor is an anti-anxiety agent, a medication or other intervention that reduces anxiety. Anxiolytic medications are used for the treatment of anxiety disorders and their related psychological and physical symptoms.
slaulederkind
2023-11-17T10:05:28Z
D014151
PMID:37966567
anti-anxiety drug
antipanic agent
anxiolytic
anxiolytic medication
experimental_condition_ontology
XCO:0001122
anti-anxiety agent
XCO:0001122
This is any condition in which the main influencing factor is an anti-anxiety agent, a medication or other intervention that reduces anxiety. Anxiolytic medications are used for the treatment of anxiety disorders and their related psychological and physical symptoms.
https://en.wikipedia.org/wiki/Anxiolytic
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is alpidem, a drug formerly used to treat anxiety disorders but its medical use was discontinued due to liver toxicity.
slaulederkind
2023-11-17T10:28:29Z
CHEBI:135649
MESH:C052036
PMID:32119089
experimental_condition_ontology
XCO:0001123
alpidem
XCO:0001123
This is any condition in which the main influencing factor is alpidem, a drug formerly used to treat anxiety disorders but its medical use was discontinued due to liver toxicity.
https://en.wikipedia.org/wiki/Alpidem
This is any condition in which the main influencing factor is amiodarone, an antianginal and class III antiarrhythmic drug that increases the duration of ventricular and atrial muscle action by inhibiting potassium channels and voltage-gated sodium channels. Following the channel inhibition is a resulting decrease in heart rate and in vascular resistance.
slaulederkind
2023-11-17T11:29:29Z
CHEBI:2663
PMID:32119089
(2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone
Amiodarona
Amiodaronum
Cordarone
experimental_condition_ontology
XCO:0001124
amiodarone
XCO:0001124
This is any condition in which the main influencing factor is amiodarone, an antianginal and class III antiarrhythmic drug that increases the duration of ventricular and atrial muscle action by inhibiting potassium channels and voltage-gated sodium channels. Following the channel inhibition is a resulting decrease in heart rate and in vascular resistance.
MESH:D000638
This is any condition in which the main influencing factor is amoxicillin, a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. Amoxicillin is a broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
slaulederkind
2023-11-17T12:03:49Z
PMID:32119089
amox
amoxycillin
experimental_condition_ontology
XCO:0001125
amoxicillin
XCO:0001125
This is any condition in which the main influencing factor is amoxicillin, a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. Amoxicillin is a broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
CHEBI:2676
MESH:D000658
This is any condition in which the main influencing factor is curcumin , a beta-diketone that is obtained from tumeric, the powdered root of Curcuma longa. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
slaulederkind
2023-11-17T14:16:02Z
PMID:37916359
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Diferuloylmethane
experimental_condition_ontology
XCO:0001126
curcumin
XCO:0001126
This is any condition in which the main influencing factor is curcumin , a beta-diketone that is obtained from tumeric, the powdered root of Curcuma longa. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
CHEBI:3962
MESH:D003474
This is any condition in which the main influencing factor is BHD (Buyang Huanwu Decoction), a multi-herbal composition (classic traditional chinese medicine formula) commonly prescribed in the treatment of cerebrovascular diseases.
slaulederkind
2023-11-17T14:41:23Z
BHD
BHF
Boyang Hwano Decoction
Bu Yang Huan WU Tang
Buyang Huanwu Formula
Buyang Huanwu Tang
experimental_condition_ontology
XCO:0001127
Buyang Huanwu decoction
XCO:0001127
This is any condition in which the main influencing factor is BHD (Buyang Huanwu Decoction), a multi-herbal composition (classic traditional chinese medicine formula) commonly prescribed in the treatment of cerebrovascular diseases.
PMID:32171896
This is any condition in which the main influencing factor is a polysaccharide derivative, a carbohydrate derivative that is any derivative of a polysaccharide (a biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically). Various molecules can be covalently attached to the hydroxyl groups of polysaccharides and thus form polysaccaride derivatives.
slaulederkind
2023-11-17T18:00:43Z
PMID:32119089
polycarbohydrate derivative
experimental_condition_ontology
XCO:0001128
polysaccharide derivative
XCO:0001128
This is any condition in which the main influencing factor is a polysaccharide derivative, a carbohydrate derivative that is any derivative of a polysaccharide (a biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically). Various molecules can be covalently attached to the hydroxyl groups of polysaccharides and thus form polysaccaride derivatives.
CHEBI:65212
https://en.wikipedia.org/wiki/Polysaccharide#Derivatives
This is any condition in which the main influencing factor is carboxymethylcellulose, a polysaccharide derivative that is cellulose in which carboxymethyl groups are bound to some of the hydroxyl groups of the glucopyranose monomers.
slaulederkind
2023-11-17T18:06:34Z
PMID:32119089
CMC
carboxymethyl cellulose
cellulose gum
experimental_condition_ontology
XCO:0001129
carboxymethylcellulose
XCO:0001129
This is any condition in which the main influencing factor is carboxymethylcellulose, a polysaccharide derivative that is cellulose in which carboxymethyl groups are bound to some of the hydroxyl groups of the glucopyranose monomers.
CHEBI:85146
https://en.wikipedia.org/wiki/Carboxymethyl_cellulose
This is any condition in which the main influencing factor is amprenavir, a protease inhibitor designed to treat HIV infections. Amprenavir has been replaced by fosamprenavir, a prodrug of amprenavir.
slaulederkind
2023-11-20T18:47:45Z
CHEBI:40050
MESH:C095108
[(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
experimental_condition_ontology
XCO:0001130
amprenavir
XCO:0001130
This is any condition in which the main influencing factor is amprenavir, a protease inhibitor designed to treat HIV infections. Amprenavir has been replaced by fosamprenavir, a prodrug of amprenavir.
https://en.wikipedia.org/wiki/Amprenavir
This is any condition in which the main influencing factor is azithromycin, a semi-synthetic, broad-spectrum, macrolide antibiotic structurally related to erythromycin. It has been used in the treatment of various types of bacterial infections.
slaulederkind
2023-11-21T10:56:37Z
CHEBI:2955
PMID:32119089
9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin
Azasite
Zithromax
experimental_condition_ontology
XCO:0001131
azithromycin
XCO:0001131
This is any condition in which the main influencing factor is azithromycin, a semi-synthetic, broad-spectrum, macrolide antibiotic structurally related to erythromycin. It has been used in the treatment of various types of bacterial infections.
MESH:D017963
https://en.wikipedia.org/wiki/Azithromycin
This is any condition in which the main influencing factor is sesame oil, an edible vegetable oil derived from sesame seeds. Sesame oil can be used as a solvent for an injected drug or an intravenous drip.
slaulederkind
2023-11-21T14:26:20Z
PMID:32119089
sesame seed oil
experimental_condition_ontology
XCO:0001132
sesame oil
XCO:0001132
This is any condition in which the main influencing factor is sesame oil, an edible vegetable oil derived from sesame seeds. Sesame oil can be used as a solvent for an injected drug or an intravenous drip.
https://en.wikipedia.org/wiki/Sesame_oil
This is any condition in which the main influencing factor is bardoxolone, a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis.
slaulederkind
2023-11-21T14:43:36Z
CHEBI:177450
CID:400010
PMID:32119089
(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid
CDDO
RTA 401
RTA-401
experimental_condition_ontology
XCO:0001133
bardoxolone
XCO:0001133
This is any condition in which the main influencing factor is bardoxolone, a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis.
NCI:C48382
This is any condition in which the main influencing factor is caffeine, a methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation.
slaulederkind
2023-11-27T18:04:45Z
CHEBI:27732
MESH:D002110
experimental_condition_ontology
XCO:0001134
caffeine
XCO:0001134
This is any condition in which the main influencing factor is caffeine, a methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation.
MESH:D002110
This is any condition in which the main influencing factor is carbamazepine, a dibenzazepine that acts as a sodium channel blocker. Carbamazepine is used as an anticonvulsant and it may also be used in the management of bipolar disorder and neuropathic pain.
slaulederkind
2023-11-30T14:31:38Z
CHEBI:3387
CID:2554
5H-dibenzo[b,f]azepine-5-carboxamide
CBZ
Tegretol
experimental_condition_ontology
XCO:0001135
carbamazepine
XCO:0001135
This is any condition in which the main influencing factor is carbamazepine, a dibenzazepine that acts as a sodium channel blocker. Carbamazepine is used as an anticonvulsant and it may also be used in the management of bipolar disorder and neuropathic pain.
MESH:D002220
https://en.wikipedia.org/wiki/Carbamazepine
This is any condition in which the main influencing factor is propylene glycol, a synthetic small organic alcohol that is hydrophylic. Propylene glycol has various laboratory, pharmaceutical, and industrial uses.
slaulederkind
2023-11-30T14:55:03Z
1,2-dihydroxypropane
1,2-propanediol
MESH:D019946
methyl glycol
trimethyl glycol
experimental_condition_ontology
XCO:0001136
propylene glycol
XCO:0001136
This is any condition in which the main influencing factor is propylene glycol, a synthetic small organic alcohol that is hydrophylic. Propylene glycol has various laboratory, pharmaceutical, and industrial uses.
CID:1030
https://en.wikipedia.org/wiki/Propylene_glycol
This is any condition in which the main influencing factor is carisoprodol, a carbamate ester which is a centrally acting skeletal muscle relaxant whose mechanism of action may be related to its sedative actions. Carisoprodol is used for the relief of discomfort associated with acute, painful musculoskeletal conditions.
slaulederkind
2023-11-30T15:30:53Z
CHEBI:3419
2-[(carbamoyloxy)methyl]-2-methylpentyl propan-2-ylcarbamate
Carisoprodate
Isomeprobamate
experimental_condition_ontology
XCO:0001137
carisoprodol
XCO:0001137
This is any condition in which the main influencing factor is carisoprodol, a carbamate ester which is a centrally acting skeletal muscle relaxant whose mechanism of action may be related to its sedative actions. Carisoprodol is used for the relief of discomfort associated with acute, painful musculoskeletal conditions.
MESH:D002328
https://www.ncbi.nlm.nih.gov/books/NBK553077
This is any condition in which the main influencing factor is cefprozil, a semisynthetic, second-generation cephalosporin. Cefprozil is used to treat bronchitis as well as ear, skin and other bacterial infections.
slaulederkind
2023-11-30T15:49:04Z
Cefzil
experimental_condition_ontology
XCO:0001138
cefprozil
XCO:0001138
This is any condition in which the main influencing factor is cefprozil, a semisynthetic, second-generation cephalosporin. Cefprozil is used to treat bronchitis as well as ear, skin and other bacterial infections.
CHEBI:3506
CID:5281006
This is any condition in which the main influencing factor is chloramphenicol, a topical,broad-spectrum antibiotic first isolated from cultures of Streptomyces venequelae but now produced synthetically. Chloramphenicol act s by interfering with bacterial protein synthesis
slaulederkind
2023-12-01T08:16:50Z
CHEBI:17698
CID:5959
2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
experimental_condition_ontology
XCO:0001139
chloramphenicol
XCO:0001139
This is any condition in which the main influencing factor is chloramphenicol, a topical,broad-spectrum antibiotic first isolated from cultures of Streptomyces venequelae but now produced synthetically. Chloramphenicol act s by interfering with bacterial protein synthesis
MESH:D002701
This is any condition in which the main influencing factor is chlormezanone, an anxiolytic drug, a muscle relaxant and an antipsychotic agent whose clinical use was discontinued because of rare but serious cutaneous reactions.
slaulederkind
2023-12-01T08:45:42Z
CID:2717
Chlormethazanone
Chlormethazone
Clormetazanone
experimental_condition_ontology
XCO:0001140
chlormezanone
XCO:0001140
This is any condition in which the main influencing factor is chlormezanone, an anxiolytic drug, a muscle relaxant and an antipsychotic agent whose clinical use was discontinued because of rare but serious cutaneous reactions.
CHEBI:3619
This is any condition in which the main influencing factor is a negative control oligonucleotide. A negative control oligonucleotide is an oligonucleotide with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental oligonucleotide used.
slaulederkind
2023-12-01T09:58:36Z
scrambled control RNA oligomer
scrambled control RNA oligonucleotide
experimental_condition_ontology
XCO:0001141
scrambled control oligonucleotide
XCO:0001141
This is any condition in which the main influencing factor is a negative control oligonucleotide. A negative control oligonucleotide is an oligonucleotide with no significant sequence similarity to eukaryotic gene sequences and may be a scrambled version of the experimental oligonucleotide used.
https://en.wikipedia.org/wiki/Oligonucleotide
https://www.oligotherapeutics.org/april-2019-paper-of-the-month/
This is any condition in which the main influencing factor is a MIR143 mimic transferred into an organism or cell culture. MIR143 mimic is a chemically modified double-stranded RNA molecule designed to mimic endogenous MIR143 function. MIR143 is associated with cardiovascular and other diseases.
slaulederkind
2023-12-01T09:58:47Z
transfection of MIR-143 mimic
transfection of MIR143 mimic
transfer of MIR-143 mimic
transfer of miR143 mimic
experimental_condition_ontology
XCO:0001142
transfer of MIR143 mimic
XCO:0001142
This is any condition in which the main influencing factor is a MIR143 mimic transferred into an organism or cell culture. MIR143 mimic is a chemically modified double-stranded RNA molecule designed to mimic endogenous MIR143 function. MIR143 is associated with cardiovascular and other diseases.
RGD:1346221
https://www.thermofisher.com/us/en/home/life-science/epigenetics-noncoding-rna-research/mirna-analysis/mirna-mimics-inhibitors.html
This is any condition in which the main influencing factor is Limosilactobacillus reuteri (a lactic acid bacterium). L. reuteri is a probiotic bacterium found in a variety of natural environments, including the gastrointestinal tract of humans and other animals.
slaulederkind
2023-12-01T11:19:30Z
PMID:37422471
L. reuteri
Lactobacillus fermentum biotype II
Lactobacillus reuteri
experimental_condition_ontology
XCO:0001143
Limosilactobacillus reuteri
XCO:0001143
This is any condition in which the main influencing factor is Limosilactobacillus reuteri (a lactic acid bacterium). L. reuteri is a probiotic bacterium found in a variety of natural environments, including the gastrointestinal tract of humans and other animals.
PMID:35336098
https://en.wikipedia.org/wiki/Limosilactobacillus_reuteri
Thhis is any condition in which the main influencing factor is chlorpropamide, an N-sulfonylurea that is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
slaulederkind
2023-12-04T11:26:47Z
PMID:32119089
CID:2727
Chloropropamide
experimental_condition_ontology
XCO:0001144
chlorpropamide
XCO:0001144
Thhis is any condition in which the main influencing factor is chlorpropamide, an N-sulfonylurea that is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
CHEBI:3650
MESH:D002747
This is any condition in which the main influencing factor is cimetidine, an H2-receptor antagonist that inhibits gastric acid secretion, as well as pepsin and gastrin output.
slaulederkind
2023-12-04T11:54:03Z
CHEBI:3699
CID:2756
PMID:32119089
2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
Tagamet
experimental_condition_ontology
XCO:0001145
cimetidine
XCO:0001145
This is any condition in which the main influencing factor is cimetidine, an H2-receptor antagonist that inhibits gastric acid secretion, as well as pepsin and gastrin output.
MESH:D002927
This is any condition in which the main influencing factor is clarithromycin, a synthetic macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. Clarithromycin is derived from erythromycin and is a protein synthesis inhibitor in bacteria.
slaulederkind
2023-12-04T13:52:47Z
CID:84029
Clarithromycine
Clathromycin
experimental_condition_ontology
XCO:0001146
clarithromycin
XCO:0001146
This is any condition in which the main influencing factor is clarithromycin, a synthetic macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. Clarithromycin is derived from erythromycin and is a protein synthesis inhibitor in bacteria.
CHEBI:3732
MESH:D017291
This is any condition whose main influencing factor is clofibrate, a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.
slaulederkind
2023-12-04T14:05:02Z
CHEBI:3750
CID:2796
PMID:32119089
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
ethyl clofibrate
experimental_condition_ontology
XCO:0001147
clofibrate
XCO:0001147
This is any condition whose main influencing factor is clofibrate, a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.
MESH:D002994
This is any condition whose main influencing factor is clopidogrel, a ticlopidine analog and platelet P2Y12 receptor antagonist that inhibits adenosine diphosphate-mediated platelet aggregation. It is used to prevent thromboembolism in patients with arterial occlusive diseases.
slaulederkind
2023-12-04T14:19:35Z
CHEBI:37941
PMID:32119089
Plavix
methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
experimental_condition_ontology
XCO:0001148
clopidogrel
XCO:0001148
This is any condition whose main influencing factor is clopidogrel, a ticlopidine analog and platelet P2Y12 receptor antagonist that inhibits adenosine diphosphate-mediated platelet aggregation. It is used to prevent thromboembolism in patients with arterial occlusive diseases.
MESH:D000077144
This is any condition whose main influencing factor is clozapine, a tricylic dibenzodiazepinethat binds several types of central nervous system receptors. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor.
slaulederkind
2023-12-04T14:30:46Z
CHEBI:3766
PMID:32119089
8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
experimental_condition_ontology
XCO:0001149
clozapine
XCO:0001149
This is any condition whose main influencing factor is clozapine, a tricylic dibenzodiazepinethat binds several types of central nervous system receptors. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor.
MESH:D003024
This is any condition whose main influencing factor is compound Z, a pterin phosphate that is an oxidation product of cPMP (fosdenopterin). It is functionally related to a neopterin. Compound Z is a pharmacologically inactive product of fosdenopterin metabolism.
slaulederkind
2023-12-04T14:51:06Z
CHEBI:60211
PMID:32119089
2-amino-6-{[(4S,5R)-2,5-dihydroxy-2-oxido-1,3,2-dioxaphosphinan-4-yl]carbonyl}pteridin-4(3H)-one
experimental_condition_ontology
XCO:0001150
compound Z
XCO:0001150
This is any condition whose main influencing factor is compound Z, a pterin phosphate that is an oxidation product of cPMP (fosdenopterin). It is functionally related to a neopterin. Compound Z is a pharmacologically inactive product of fosdenopterin metabolism.
CID:135889290
This is any condition whose main influencing factor is Augmentin, a fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate. Augmentin is a broad-spectrum antibiotic.
slaulederkind
2023-12-04T15:22:17Z
CID:23665637
MESH:D019980
PMID:32119089
Amoxicillin clavulanate potassium
Amoxicillin-Clavulanic Acid
Amoxycillin-Clavulanic Acid
Clavamox
co-amoxiclav
experimental_condition_ontology
XCO:0001151
Augmentin
XCO:0001151
This is any condition whose main influencing factor is Augmentin, a fixed-ratio combination of amoxicillin trihydrate and potassium clavulanate. Augmentin is a broad-spectrum antibiotic.
MESH:D019980
This is any condition whose main influencing factor is diltiazem, a benzothiazepine derivative that is a calcium-channel blocker and vasodilator. Diltiazem is used in the hydrochloride form in the management of angina pectoris and hypertension.
slaulederkind
2023-12-04T15:40:48Z
CID:39186
MESH:D004110
PMID:32119089
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
experimental_condition_ontology
XCO:0001152
diltiazem
XCO:0001152
This is any condition whose main influencing factor is diltiazem, a benzothiazepine derivative that is a calcium-channel blocker and vasodilator. Diltiazem is used in the hydrochloride form in the management of angina pectoris and hypertension.
CHEBI:101278
This is any condition whose main influencing factor is diphenhydramine, an histamine H1 antagonist used for for hypersensitivity reactions, for pruritus, as a hypnotic, and as an ingredient in common cold preparations.
slaulederkind
2023-12-04T15:53:25Z
CHEBI:4636
CID:3100
PMID:32119089
2-(diphenylmethoxy)-N,N-dimethylethanamine
Benedryl
experimental_condition_ontology
XCO:0001153
diphenhydramine
XCO:0001153
This is any condition whose main influencing factor is diphenhydramine, an histamine H1 antagonist used for for hypersensitivity reactions, for pruritus, as a hypnotic, and as an ingredient in common cold preparations.
MESH:D004155
This is any condition whose main influencing factor is dipyridamole, a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole is an inhibitor of platelet aggregation and a vasodilator agent.
slaulederkind
2023-12-05T12:10:08Z
CID:3108
PMID:32119089
2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine
experimental_condition_ontology
XCO:0001154
dipyridamole
XCO:0001154
This is any condition whose main influencing factor is dipyridamole, a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole is an inhibitor of platelet aggregation and a vasodilator agent.
CHEBI:4653
MESH:D004176
This is any condition whose main influencing factor is disopyramide, a sodium channel blocker and class I anti-arrhythmic agent with a depressant action on the heart similar to that of guanidine. Disopyramide also possesses some anticholinergic and local anesthetic properties.
slaulederkind
2023-12-05T13:44:50Z
CHEBI:4657
CID:3114
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
experimental_condition_ontology
XCO:0001155
disopyramide
XCO:0001155
This is any condition whose main influencing factor is disopyramide, a sodium channel blocker and class I anti-arrhythmic agent with a depressant action on the heart similar to that of guanidine. Disopyramide also possesses some anticholinergic and local anesthetic properties.
MESH:D004206
https://en.wikipedia.org/wiki/Disopyramide
This is any condition whose main influencing factor is erythromycin, any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (Streptomyces erythraeus). Erythromycin inhibits protein synthesis by binding to 50S ribosomal subunits, thus interfering with translocation of amino acids during translation and assembly of proteins
slaulederkind
2023-12-05T13:56:45Z
CID:12560
PMID:32119089
experimental_condition_ontology
XCO:0001156
erythromycin
XCO:0001156
This is any condition whose main influencing factor is erythromycin, any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (Streptomyces erythraeus). Erythromycin inhibits protein synthesis by binding to 50S ribosomal subunits, thus interfering with translocation of amino acids during translation and assembly of proteins
CHEBI:48923
MESH:D004917
This is any condition in which the main influencing factor is esomeprazole, an inhibitor of gastric acid secretion used for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome.
slaulederkind
2023-12-05T14:18:05Z
CID:9568614
MESH:D064098
experimental_condition_ontology
XCO:0001157
esomeprazole
XCO:0001157
This is any condition in which the main influencing factor is esomeprazole, an inhibitor of gastric acid secretion used for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome.
CHEBI:50275
This is any condition whose main influencing factor is ethambutol, an ethylenediamine derivative that is an antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria.
slaulederkind
2023-12-05T14:29:06Z
CID:14052
MESH:D004977
PMID:32119089
(2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol
experimental_condition_ontology
XCO:0001158
ethambutol
XCO:0001158
This is any condition whose main influencing factor is ethambutol, an ethylenediamine derivative that is an antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria.
CHEBI:4877
This is any condition whose main influencing factor is felbamate, a PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA receptors. Felbamate is used as an anticonvulsant, primarily for the treatment of seizures in severe refractory epilepsy.
slaulederkind
2023-12-07T11:57:35Z
CHEBI:4995
PMID:32119089
2-phenylpropane-1,3-diyl dicarbamate
experimental_condition_ontology
XCO:0001159
felbamate
XCO:0001159
This is any condition whose main influencing factor is felbamate, a PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA receptors. Felbamate is used as an anticonvulsant, primarily for the treatment of seizures in severe refractory epilepsy.
MESH:D000078328
This is any condition in which the main influencing factor is flucloxacillin, a penicillin anti-bacterial drug used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone
slaulederkind
2023-12-07T13:24:24Z
CHEBI:5098
CID:21319
6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido]-2,2-dimethylpenam-3alpha-carboxylic acid
Floxacillin
experimental_condition_ontology
XCO:0001160
flucloxacillin
XCO:0001160
This is any condition in which the main influencing factor is flucloxacillin, a penicillin anti-bacterial drug used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone
MESH:D005436
https://en.wikipedia.org/wiki/Flucloxacillin
This is any condition whose main influencing factor is fluoxetine, the first highly specific serotonin reuptake inhibitor (SSRI). It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
slaulederkind
2023-12-07T13:36:29Z
CID:3386
Methyl({3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl})amine
N-Methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine
rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
experimental_condition_ontology
XCO:0001161
fluoxetine
XCO:0001161
This is any condition whose main influencing factor is fluoxetine, the first highly specific serotonin reuptake inhibitor (SSRI). It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
MESH:D005473
This is any condition in which the main influencing factor is flutamide ,a monocarboxylic acid amide which has a role as an androgen receptor antagonist and an antineoplastic agent.
slaulederkind
2023-12-07T13:51:59Z
CHEBI:5132
MESH:D005485
2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
4'-Nitro-3'-trifluoromethylisobutyranilide
NFBA
niftolid
experimental_condition_ontology
XCO:0001162
flutamide
XCO:0001162
This is any condition in which the main influencing factor is flutamide ,a monocarboxylic acid amide which has a role as an androgen receptor antagonist and an antineoplastic agent.
CID:3397
This is any condition whose main influencing factor is hydroxyzine, a histamine H1 receptor antagonist that is an anxiolytic drug, a dermatologic drug, an antipruritic drug and an anticoronaviral agent.
slaulederkind
2023-12-07T14:15:00Z
CHEBI:5818
PMID:32119089
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol
experimental_condition_ontology
XCO:0001163
hydroxyzine
XCO:0001163
This is any condition whose main influencing factor is hydroxyzine, a histamine H1 receptor antagonist that is an anxiolytic drug, a dermatologic drug, an antipruritic drug and an anticoronaviral agent.
CID:3658
MESH:D006919
This is any condition whose main influencing factor is labetalol, a salicylamide derivative that is a non-cardioselective blocker of beta-adrenergic receptors and alpha-1 adrenergic receptors used to treat high blood pressure.
slaulederkind
2023-12-07T15:57:48Z
CID:3869
PMID:32119089
2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide
3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol
kabetalol
experimental_condition_ontology
XCO:0001164
labetalol
XCO:0001164
This is any condition whose main influencing factor is labetalol, a salicylamide derivative that is a non-cardioselective blocker of beta-adrenergic receptors and alpha-1 adrenergic receptors used to treat high blood pressure.
CHEBI:6343
MESH:D007741
This is any condition whose main influencing factor is lapatinib, a quinazoline derivative that inhibits epidermal growth factor receptor (Egfr) and erb-b2 receptor tyrosine kinase 2 (Erbb2/Her2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress Erbb2/Her2.
slaulederkind
2023-12-07T19:22:36Z
CHEBI:49603
CID:208908
N-[3-chloro-4-(3-fluorobenzyloxy)phenyl]-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
lapatinib ditosylate
experimental_condition_ontology
XCO:0001165
lapatinib
XCO:0001165
This is any condition whose main influencing factor is lapatinib, a quinazoline derivative that inhibits epidermal growth factor receptor (Egfr) and erb-b2 receptor tyrosine kinase 2 (Erbb2/Her2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress Erbb2/Her2.
MESH:D000077341
This is any condition in which the main influencing factor is hydroxypropyl methylcellulose, a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
slaulederkind
2023-12-07T19:37:18Z
CHEBI:30618
(hydroxypropyl)methyl cellulose
HPMC
hydroxypropyl methyl cellulose
hypromellose
experimental_condition_ontology
XCO:0001166
hydroxypropyl methylcellulose
XCO:0001166
This is any condition in which the main influencing factor is hydroxypropyl methylcellulose, a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
https://en.wikipedia.org/wiki/Hypromellose
This is any condition in which the main influencing factor is any poly(ethylene glycol) derivative composed of PEG-ylated sorbitan [2-(1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol] normally containing a total of 20 oxyethylene groups, with one or more of the terminal hydroxy groups esterified with a fatty acyl group. They are used as emulsifiers and dispersing agents in some pharmaceuticals products and as defoamers and emulsifiers in some foods.
slaulederkind
2023-12-07T19:52:38Z
polysorbates
tweens
experimental_condition_ontology
XCO:0001167
polysorbate
XCO:0001167
This is any condition in which the main influencing factor is any poly(ethylene glycol) derivative composed of PEG-ylated sorbitan [2-(1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol] normally containing a total of 20 oxyethylene groups, with one or more of the terminal hydroxy groups esterified with a fatty acyl group. They are used as emulsifiers and dispersing agents in some pharmaceuticals products and as defoamers and emulsifiers in some foods.
CHEBI:53422
This is any condition in which the main influencing factor is polysorbate 80, a polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group. Polysorbate 80 is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
slaulederkind
2023-12-07T20:01:09Z
Kolliphor PS 80
PS 80
Tween 80
polyoxyethylene (80) sorbitan monooleate
experimental_condition_ontology
XCO:0001168
polysorbate 80
XCO:0001168
This is any condition in which the main influencing factor is polysorbate 80, a polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group. Polysorbate 80 is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
CHEBI:53426
https://en.wikipedia.org/wiki/Polysorbate_80
This is any condition in which the vehicle is made up of deionized water and a specified amount of ethanol, serving as a solvent for some specified chemical.
slaulederkind
2023-12-07T22:13:55Z
ethanol in deionized water used as vehicle
experimental_condition_ontology
XCO:0001169
controlled ethanol content deionized water used as vehicle
XCO:0001169
This is any condition in which the vehicle is made up of deionized water and a specified amount of ethanol, serving as a solvent for some specified chemical.
https://www.merriam-webster.com/
This is any condition whose main influencing factor is levofloxacin, a fluoroquinolone antibiotic with activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin is an inhibitor of bacterial topoisomerase IV and DNA gyrase.
slaulederkind
2023-12-08T14:26:27Z
CHEBI:63598
MESH:D064704
(3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
experimental_condition_ontology
XCO:0001170
levofloxacin
true
XCO:0001170
This is any condition whose main influencing factor is levofloxacin, a fluoroquinolone antibiotic with activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin and remains stereochemically stable following administration (i.e. it does not invert to the inactive isomer). Levofloxacin is an inhibitor of bacterial topoisomerase IV and DNA gyrase.
CID:149096
This is any condition whose main influencing factor is levofloxacin, a fluoroquinolone antibiotic that is active against both gram-negative and gram-positive bacteria. Levofloxacin is an inhibitor of both bacterial topoisomerase IV and DNA gyrase.
slaulederkind
2023-12-08T15:45:16Z
XCO:0001170
CHEBI:63598
MESH:D064704
(3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
levofloxacin
experimental_condition_ontology
XCO:0001171
levofloxacin
XCO:0001171
This is any condition whose main influencing factor is levofloxacin, a fluoroquinolone antibiotic that is active against both gram-negative and gram-positive bacteria. Levofloxacin is an inhibitor of both bacterial topoisomerase IV and DNA gyrase.
CHEBI:63598
CID:149096
This is any condition in which the main influencing factor is lopinavir, an HIV protease inhibitor used in a fixed-dose combination with ritonavir. Lopinavir is also a cytochrome P-450 inhibitor.
slaulederkind
2023-12-08T16:01:36Z
CHEBI:31781
CID:92727
(2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
LPV
experimental_condition_ontology
XCO:0001172
lopinavir
XCO:0001172
This is any condition in which the main influencing factor is lopinavir, an HIV protease inhibitor used in a fixed-dose combination with ritonavir. Lopinavir is also a cytochrome P-450 inhibitor.
MESH:D061466
This is any condition in which the main influencing factor is loracarbef, a carbacephem antibiotic used to treat a wide range of infections caused by both gram-positive and gram-negative bacteria.
slaulederkind
2023-12-08T16:13:54Z
CHEBI:47544
7beta-[(2R)-2-amino-2-phenylacetyl]nitrilo-3-chloro-3,4-didehydrocepham-4-carboxylic acid
loracarbef anhydrous
experimental_condition_ontology
XCO:0001173
loracarbef
XCO:0001173
This is any condition in which the main influencing factor is loracarbef, a carbacephem antibiotic used to treat a wide range of infections caused by both gram-positive and gram-negative bacteria.
CID:5284585
This is any condition whose main influencing factor is lumiracoxib, a highly selective cyclooxygenase 2 inhibitor used for the treatment of osteoarthritis until it was withdrawn from use due to concerns of hepatotoxicity.
slaulederkind
2023-12-08T16:29:47Z
CID:151166
MESH:C473384
PMID:32119089
LUR
lumiracoxibum
{2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
experimental_condition_ontology
XCO:0001174
lumiracoxib
XCO:0001174
This is any condition whose main influencing factor is lumiracoxib, a highly selective cyclooxygenase 2 inhibitor used for the treatment of osteoarthritis until it was withdrawn from use due to concerns of hepatotoxicity.
CHEBI:73044
This is any condition in which the main influencing factor is acetone, a methyl ketone that consists of propane bearing an oxo group at C2. Acetone is used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis. Acetone is used to make drugs and other chemicals.
slaulederkind
2023-12-08T19:35:08Z
MESH:D000096
2-propanal
2-propanone
beta-ketopropane
dimethyl ketone
propan-2-one
experimental_condition_ontology
XCO:0001175
acetone
XCO:0001175
This is any condition in which the main influencing factor is acetone, a methyl ketone that consists of propane bearing an oxo group at C2. Acetone is used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis. Acetone is used to make drugs and other chemicals.
CHEBI:15347
CID:180
This is any condition whose main influencing factor is LY2886721, an inhibitor of protease beta-secretase 1 (BACE1), which is a key protease controlling the formation of amyloid β (a peptide hypothesized to play a significant role in the pathogenesis of Alzheimer's disease).
slaulederkind
2023-12-09T10:23:21Z
CID:49837968
PMID:32119089
LY-2886721
N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide
experimental_condition_ontology
XCO:0001176
LY2886721
XCO:0001176
This is any condition whose main influencing factor is LY2886721, an inhibitor of protease beta-secretase 1 (BACE1), which is a key protease controlling the formation of amyloid β (a peptide hypothesized to play a significant role in the pathogenesis of Alzheimer's disease).
PMID:25609634
This is any condition in which the main influencing factor is megestrol, a 3-oxo Delta(4)-steroid that is a progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. Megestrol has also been used in the palliative treatment of breast cancer and as an appetite enhancer in cachectic subjects.
slaulederkind
2023-12-09T10:34:00Z
CID:19090
PMID:32119089
17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
6-Methyl-17-hydroxypregna-4,6-diene-3,20-dione
Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
experimental_condition_ontology
XCO:0001177
megestrol
XCO:0001177
This is any condition in which the main influencing factor is megestrol, a 3-oxo Delta(4)-steroid that is a progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. Megestrol has also been used in the palliative treatment of breast cancer and as an appetite enhancer in cachectic subjects.
CHEBI:6722
MESH:D008535
This is any condition in which the main influencing factor is methimazole, a thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin through inhibition of the peroxidase enzyme.
slaulederkind
2023-12-09T11:24:32Z
CHEBI:50673
CID:1349907
1-Methyl-2-mercaptoimidazole
1-Methylimidazole-2-thiol
2-Mercapto-1-methylimidazole
experimental_condition_ontology
XCO:0001178
methimazole
XCO:0001178
This is any condition in which the main influencing factor is methimazole, a thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin through inhibition of the peroxidase enzyme.
MESH:D008713
This is any condition in which the main influencing factor is iopromide, an organoiodine compound and a dicarboxylic acid diamide used as an x-ray contrast agent for angiography. Iopromide is also a nephrotoxic agent.
slaulederkind
2023-12-11T15:49:02Z
CHEBI:63578
MESH:C038192
N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylisophthalamide
iopromid
experimental_condition_ontology
XCO:0001179
iopromide
XCO:0001179
This is any condition in which the main influencing factor is iopromide, an organoiodine compound and a dicarboxylic acid diamide used as an x-ray contrast agent for angiography. Iopromide is also a nephrotoxic agent.
CID:3736
This is any condition in which the major influencing factor is OC43p, a synthetic peptide whose sequence (VSKIVHFFKTFTTSTALAFA) is derived from the Human coronavirus OC43 gene ORF1ab/ORF1ab polyprotein. This sequence is homologous to the myelin basic protein pronociceptive peptide MBP84-104 from human/rat.
slaulederkind
2023-12-11T16:45:35Z
OC43:653-673
VSKIVHFFKTFTTSTALAFA
human coronavirus OC43‐encoded polypeptide
experimental_condition_ontology
MHV p65-like protein
ORF1a polyprotein
ORF1ab polyprotein
polyprotein pp1a
polyprotein pp1ab
XCO:0001180
OC43p
XCO:0001180
This is any condition in which the major influencing factor is OC43p, a synthetic peptide whose sequence (VSKIVHFFKTFTTSTALAFA) is derived from the Human coronavirus OC43 gene ORF1ab/ORF1ab polyprotein. This sequence is homologous to the myelin basic protein pronociceptive peptide MBP84-104 from human/rat.
PMID:35466531
This is any condition in which the major influencing factor is OC43p-SCR, a synthetic peptide whose sequence (VFIAHSVKFTKSFTLATTFA) is a scrambled version of OC43p, a peptide derived from the Human coronavirus OC43 gene ORF1ab/ORF1ab polyprotein. This OC43p‐SCR sequence is used as an experimental control for OC43p.
slaulederkind
2023-12-11T17:22:19Z
OC43p‐SCR1
VFIAHSVKFTKSFTLATTFA
experimental_condition_ontology
XCO:0001181
OC43p‐SCR
XCO:0001181
This is any condition in which the major influencing factor is OC43p-SCR, a synthetic peptide whose sequence (VFIAHSVKFTKSFTLATTFA) is a scrambled version of OC43p, a peptide derived from the Human coronavirus OC43 gene ORF1ab/ORF1ab polyprotein. This OC43p‐SCR sequence is used as an experimental control for OC43p.
PMID:35466531
This is any condition in which the main influencing factor is methyldopa, a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa is in the alpha-2 adrenergic receptor agonist family of medications. It works by stimulating the brain to decrease the activity of the sympathetic nervous system.
slaulederkind
2023-12-12T13:26:35Z
MESH:D008750
α-methyldopa
alpha medopa
alpha-methyl-L-dopa
alphamethyldopa
experimental_condition_ontology
XCO:0001182
methyldopa
XCO:0001182
This is any condition in which the main influencing factor is methyldopa, a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa is in the alpha-2 adrenergic receptor agonist family of medications. It works by stimulating the brain to decrease the activity of the sympathetic nervous system.
CID:38853
https://en.wikipedia.org/wiki/Methyldopa
This is any condition in which the main influencing factor is metiamide, a histamine H2 receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate compound in the development of the successful anti-ulcer drug cimetidine.
slaulederkind
2023-12-12T13:48:07Z
CHEBI:6896
CID:1548992
PMID:32119089
1-Methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)thiourea
N-Methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)thiourea
methiamide
experimental_condition_ontology
XCO:0001183
metiamide
XCO:0001183
This is any condition in which the main influencing factor is metiamide, a histamine H2 receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate compound in the development of the successful anti-ulcer drug cimetidine.
https://en.wikipedia.org/wiki/Metiamide
This is any condition in which the main influencing factor is mibefradil, a benzimidazoyl-substituted tetralin that selectively binds and inhibits T-type calcium channels. Mibefradil is a vasodilator and antihypertensive agent.
slaulederkind
2023-12-12T14:02:56Z
CHEBI:6920
CID:60663
Acetic acid, methoxy-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, (1S-cis)-
[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyacetate
experimental_condition_ontology
XCO:0001184
mibefradil
XCO:0001184
This is any condition in which the main influencing factor is mibefradil, a benzimidazoyl-substituted tetralin that selectively binds and inhibits T-type calcium channels. Mibefradil is a vasodilator and antihypertensive agent.
MESH:D020748
This is any condition in which the main influencing factor is MK-0773, an experimental drug that was under development for the treatment of sarcopenia. MK-0773 is a 4-azasteroid and agonist of the androgen receptor (SARM, selective androgen receptor modulator).
slaulederkind
2023-12-12T14:42:14Z
CID:11950726
PMID:32119089
(1S,3aS,3bS,5aR,9aS,9bS,11aS)-8-fluoro-N-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide
PF-05314882
experimental_condition_ontology
XCO:0001185
MK-0773
XCO:0001185
This is any condition in which the main influencing factor is MK-0773, an experimental drug that was under development for the treatment of sarcopenia. MK-0773 is a 4-azasteroid and agonist of the androgen receptor (SARM, selective androgen receptor modulator).
https://en.wikipedia.org/wiki/MK-0773
This is any condition in which the main influencing factor is MK-03207, a highly potent calcitonin gene-related peptide (CGRP) receptor antagonist designed to be an antimigraine therapeutic.
slaulederkind
2023-12-12T14:57:03Z
CID:25019940
2-((8R)-8-(3,5-Difluorophenyl)-10-oxo-6,9-diazaspiro(4.5)dec-9-yl)-N-((2R)-2'-oxo-1,1',2',3-tetrahydrospiro(indene-2,3'-pyrrolo(2,3-b)pyridin)-5-yl)acetamide
MK3207
experimental_condition_ontology
XCO:0001186
MK-3207
XCO:0001186
This is any condition in which the main influencing factor is MK-03207, a highly potent calcitonin gene-related peptide (CGRP) receptor antagonist designed to be an antimigraine therapeutic.
PMID:24900170
This is any condition in which the main influencing factor is ampicillin, a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.
slaulederkind
2023-12-14T12:00:21Z
CHEBI:28971
MESH:D000667
6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
aminobenzylpenicillin
experimental_condition_ontology
XCO:0001187
ampicillin
XCO:0001187
This is any condition in which the main influencing factor is ampicillin, a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.
CID:6249
This is any condition in which the main influencing factor is neomycin sulfate, the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin is a protein synthesis inhibitor and bacteriacidal agent.
slaulederkind
2023-12-14T13:05:10Z
CHEBI:31635
PMID:32119089
SID:483925982
experimental_condition_ontology
XCO:0001188
neomycin sulfate
XCO:0001188
This is any condition in which the main influencing factor is neomycin sulfate, the sulfate salt form of neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin is a protein synthesis inhibitor and bacteriacidal agent.
https://pubchem.ncbi.nlm.nih.gov/#query=neomycin%20sulfate
This is any condition in which the main influencing factor is metronidazole, a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. Metronidazole is frequently used to treat gastrointestinal infections and parasitic infections such as trichomoniasis, giardiasis, and amebiasis. The antiparasitic of properties of metronidazole set it apart from many other antibacterial drugs, allowing it to treat a wider variety of infections.
slaulederkind
2023-12-14T13:22:30Z
CHEBI:6909
MESH:D008795
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol
experimental_condition_ontology
XCO:0001189
metronidazole
XCO:0001189
This is any condition in which the main influencing factor is metronidazole, a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. Metronidazole is frequently used to treat gastrointestinal infections and parasitic infections such as trichomoniasis, giardiasis, and amebiasis. The antiparasitic of properties of metronidazole set it apart from many other antibacterial drugs, allowing it to treat a wider variety of infections.
CID:4173
This is any condition in which the main influencing factor is amphotericin B, macrolide antifungal and antiprotozoal antibiotic produced by Streptomyces nodosus.
slaulederkind
2023-12-14T13:36:38Z
CHEBI:2682
(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
amphotericin
experimental_condition_ontology
XCO:0001190
amphotericin B
XCO:0001190
This is any condition in which the main influencing factor is amphotericin B, macrolide antifungal and antiprotozoal antibiotic produced by Streptomyces nodosus.
CID:5280965
MESH:D000666
This is any condition in which the main influencing factor is nabumetone, a prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid. Nabumetone is a methyl ketone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with osteoarthritis and rheumatoid arthritis.
slaulederkind
2023-12-15T11:08:39Z
CID:4409
PMID:32119089
4-(6-Methoxy-2-naphthyl)-2-butanone
4-(6-methoxynaphthalen-2-yl)butan-2-one
Relafen
experimental_condition_ontology
XCO:0001191
nabumetone
XCO:0001191
This is any condition in which the main influencing factor is nabumetone, a prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid. Nabumetone is a methyl ketone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with osteoarthritis and rheumatoid arthritis.
CHEBI:7443
MESH:D000077430
This is any condition in which the main influencing factor is nadolol, a non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used to treat vascular headaches.
slaulederkind
2023-12-15T11:34:46Z
CHEBI:7444
rac-(2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol
experimental_condition_ontology
XCO:0001192
nadolol
XCO:0001192
This is any condition in which the main influencing factor is nadolol, a non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used to treat vascular headaches.
CID:39147
MESH:D009248
This is any condition in which the main influencing factor is naproxen, a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness. Naproxen inhibits both the COX-1 and COX-2 enzymes.
slaulederkind
2023-12-15T11:49:04Z
CID:156391
MESH:D009288
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid
experimental_condition_ontology
XCO:0001193
naproxen
XCO:0001193
This is any condition in which the main influencing factor is naproxen, a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness. Naproxen inhibits both the COX-1 and COX-2 enzymes.
CHEBI:7476
This is any condition in which the main influencing factor is NB-360, a dual BACE1/BACE2 (beta-secretase 1/beta-secretase 2) inhibitor that stops the progression of amyloid-β (Aβ) deposition and reduces neuroinflammation.
slaulederkind
2023-12-15T15:38:28Z
CAS:1262857-73-7
CID:66665322
PMID:32119089
experimental_condition_ontology
NB-360 HCl
XCO:0001194
NB-360
XCO:0001194
This is any condition in which the main influencing factor is NB-360, a dual BACE1/BACE2 (beta-secretase 1/beta-secretase 2) inhibitor that stops the progression of amyloid-β (Aβ) deposition and reduces neuroinflammation.
https://www.medchemexpress.com/nb-360.html
This is any condition in which the main influencing factor is nefazodone, an aromatic ether with multiple roles, including that of an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic.
slaulederkind
2023-12-28T13:14:53Z
CHEBI:7494
MESH:C051752
2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
experimental_condition_ontology
XCO:0001195
nefazodone
XCO:0001195
This is any condition in which the main influencing factor is nefazodone, an aromatic ether with multiple roles, including that of an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic.
CID:4449
This is any condition in which the main influencing factor is an ether, any of a class of compounds that contain an ether group, an oxygen atom connected to two alkyl or aryl groups. They have the general formula R−O−R′, where R and R′ represent the alkyl or aryl groups.
slaulederkind
2023-12-28T13:36:58Z
CHEBI:25698
MESH:D004987
experimental_condition_ontology
XCO:0001196
ethers
XCO:0001196
This is any condition in which the main influencing factor is an ether, any of a class of compounds that contain an ether group, an oxygen atom connected to two alkyl or aryl groups. They have the general formula R−O−R′, where R and R′ represent the alkyl or aryl groups.
https://en.wikipedia.org/wiki/Ether
This is any condition in which the main influencing factor is nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infections and acquired immunodeficiency syndrome (AIDS).
slaulederkind
2023-12-28T13:52:45Z
CHEBI:63613
11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one
experimental_condition_ontology
XCO:0001197
nevirapine
XCO:0001197
This is any condition in which the main influencing factor is nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infections and acquired immunodeficiency syndrome (AIDS).
CID:4463
MESH:D019829
This is any condition in which the main influencing factor is nitrofurantoin, a urinary anti-bacterial agent effective against most gram-positive and gram-negative organisms. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.
slaulederkind
2023-12-28T14:15:53Z
CHEBI:71415
1-{[(5-nitro-2-furyl)methylene]amino}imidazolidine-2,4-dione
experimental_condition_ontology
XCO:0001198
nitrofurantoin
XCO:0001198
This is any condition in which the main influencing factor is nitrofurantoin, a urinary anti-bacterial agent effective against most gram-positive and gram-negative organisms. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein.
CID:6604200
MESH:D009582
This is any condition in which the main influencing factor is oxandrolone, a synthetic, anabolic steroid hormone analog of testosterone.
slaulederkind
2023-12-29T11:30:06Z
CHEBI:7820
MESH:D010074
17beta-hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one
DODECAHYDRO-3-HYDROXY-6-(HYDROXY-METHYL)-3,3A,6-TRIMETH YL-1H-BENZ
experimental_condition_ontology
XCO:0001199
oxandrolone
XCO:0001199
This is any condition in which the main influencing factor is oxandrolone, a synthetic, anabolic steroid hormone analog of testosterone.
CID:5878
This is any condition in which the main influencing factor is panadiplon (U-78875), an anxiolytic drug with a novel chemical structure. Panadiplon has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and relatively little sedative or amnestic effect, and so is classified as a nonbenzodiazepine anxiolytic.
slaulederkind
2023-12-29T12:44:41Z
CAS:124423-84-3
CID:3033821
U-78875
experimental_condition_ontology
XCO:0001200
panadiplon
XCO:0001200
This is any condition in which the main influencing factor is panadiplon (U-78875), an anxiolytic drug with a novel chemical structure. Panadiplon has a similar pharmacological profile to the benzodiazepine family of drugs, but with mainly anxiolytic properties and relatively little sedative or amnestic effect, and so is classified as a nonbenzodiazepine anxiolytic.
https://en.wikipedia.org/wiki/Panadiplon
This is any condition in which the main influencing factor is paroxetine, a serotonin uptake inhibitor that is effective in the treatment of depression and anxiety.
slaulederkind
2023-12-29T13:24:50Z
CID:43815
MESH:D017374
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, (3S,4R)-
experimental_condition_ontology
XCO:0001201
paroxetine
XCO:0001201
This is any condition in which the main influencing factor is paroxetine, a serotonin uptake inhibitor that is effective in the treatment of depression and anxiety.
CHEBI:7936
This is any condition in which the main influencing factor is a penicillin, one of a group of β-lactam antibiotics originally obtained from Penicillium molds. Penicillins are widely used for different bacterial infections, though many types of bacteria have developed resistance following extensive use.
slaulederkind
2023-12-29T13:38:29Z
CHEBI:17334
D010406
PMID:32119089
P
PCN
PEN
penicillins
penicillin G
penicillin V
experimental_condition_ontology
XCO:0001202
penicillin
XCO:0001202
This is any condition in which the main influencing factor is a penicillin, one of a group of β-lactam antibiotics originally obtained from Penicillium molds. Penicillins are widely used for different bacterial infections, though many types of bacteria have developed resistance following extensive use.
https://en.wikipedia.org/wiki/Penicillin
This is any condition in which the main influencing factor is phenobarbital, a barbiturate that acts as a nonselective central nervous system depressant. Phenobarbital potentiates GABA action on GABA-A receptors, modulates chloride currents through receptor channels, and inhibits glutamate induced depolarizations.
slaulederkind
2023-12-29T17:24:51Z
CID:4763
MESH:D010634
Luminal
phenobarb
phenobarbitone
experimental_condition_ontology
XCO:0001203
phenobarbital
XCO:0001203
This is any condition in which the main influencing factor is phenobarbital, a barbiturate that acts as a nonselective central nervous system depressant. Phenobarbital potentiates GABA action on GABA-A receptors, modulates chloride currents through receptor channels, and inhibits glutamate induced depolarizations.
MESH:D010634
This is any condition in which the main influencing factor is pentoxifylline, a synthetic dimethylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. Pentoxifylline has both anti-oxidant and anti-inflammatory properties.
slaulederkind
2024-01-02T14:30:47Z
CHEBI:7986
PMID:32119089
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
PTX
experimental_condition_ontology
XCO:0001204
pentoxifylline
XCO:0001204
This is any condition in which the main influencing factor is pentoxifylline, a synthetic dimethylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. Pentoxifylline has both anti-oxidant and anti-inflammatory properties.
CID:4740
MESH:D010431
This is any condition in which the main influencing factor is perhexiline maleate, a coronary vasodilator used as a prophylactic antianginal agent. Perhexiline inhibits mitochondrial carnitine palmitoyltransferase-1 and -2.
slaulederkind
2024-01-02T14:59:49Z
CID:5284439
PMID:32119089
2-(2,2-dicyclohexylethyl)piperidine
Piperidine, 2-(2,2-dicyclohexylethyl)-
perhexiline
experimental_condition_ontology
XCO:0001205
perhexiline maleate
XCO:0001205
This is any condition in which the main influencing factor is perhexiline maleate, a coronary vasodilator used as a prophylactic antianginal agent. Perhexiline inhibits mitochondrial carnitine palmitoyltransferase-1 and -2.
MESH:D010480
PMID:37110858
This is any condition in which the main influencing factor is probenecid, the prototypical uricosuric agent, a drug that promotes the excretion of uric acid. Probenecid inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Because probenecid reduces the renal tubular excretion of other drugs, it has been used as an adjunct to antibacterial therapy.
slaulederkind
2024-01-02T15:14:50Z
CHEBI:8426
CID:4911
4-(Dipropylsulfamoyl)benzoic acid
p-(Dipropylsulfamoyl)benzoic acid
probenecid acid
experimental_condition_ontology
XCO:0001206
probenecid
XCO:0001206
This is any condition in which the main influencing factor is probenecid, the prototypical uricosuric agent, a drug that promotes the excretion of uric acid. Probenecid inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Because probenecid reduces the renal tubular excretion of other drugs, it has been used as an adjunct to antibacterial therapy.
MESH:D011339
https://www.sciencedirect.com/topics/neuroscience/uricosuric
This is any condition in which the main influencing factor is propranolol, a widely used non-cardioselective beta-adrenergic antagonist. Propranolol functions as an anxiolytic drug, an anti-arrhythmia drug, a vasodilator agent, and an antihypertensive agent.
slaulederkind
2024-01-02T16:01:49Z
CHEBI:8499
PMID:32119089
1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-
3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol
beta-Propranolol
experimental_condition_ontology
XCO:0001207
propranolol
XCO:0001207
This is any condition in which the main influencing factor is propranolol, a widely used non-cardioselective beta-adrenergic antagonist. Propranolol functions as an anxiolytic drug, an anti-arrhythmia drug, a vasodilator agent, and an antihypertensive agent.
CID:4946
MESH:D011433
This is any condition in which the main influencing factor is MWNT-7, a multi‐walled carbon nanotube, which is a molecule consisting of three or more concentric graphene cylinders. Fibers of MWNT-7 range in size from 5.11 μm to 84.7 nm.
slaulederkind
2024-01-04T12:18:08Z
MWCNT-7
Mitsui-7
NT50a
XNRI-7
experimental_condition_ontology
XCO:0001208
MWNT-7
XCO:0001208
This is any condition in which the main influencing factor is MWNT-7, a multi‐walled carbon nanotube, which is a molecule consisting of three or more concentric graphene cylinders. Fibers of MWNT-7 range in size from 5.11 μm to 84.7 nm.
CHEBI:50596
PMID:37513116
This is any condition in which the main influencing factor is lixisenatide, a 44 amino acid polypeptide and glucagon-like peptide 1 receptor agonist used as an adjunct to diet and exercise for the treatment of adults with type II diabetes.
slaulederkind
2024-01-04T13:20:30Z
CID:90472060
PMID:37423944
H-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK-NH2
experimental_condition_ontology
XCO:0001209
lixisenatide
XCO:0001209
This is any condition in which the main influencing factor is lixisenatide, a 44 amino acid polypeptide and glucagon-like peptide 1 receptor agonist used as an adjunct to diet and exercise for the treatment of adults with type II diabetes.
CHEBI:85662
https://en.wikipedia.org/wiki/Lixisenatide
This is any condition in which the main influencing factor is neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is a minor component and a degradation product of B and C. Neomycin is a protein synthesis inhibitor and bacteriacidal agent, primarily effective against gram-negative bacteria.
slaulederkind
2024-01-05T11:08:45Z
CHEBI:7507
MESH:D009355
PMID:33790226
experimental_condition_ontology
XCO:0001210
neomycin
XCO:0001210
This is any condition in which the main influencing factor is neomycin, a broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is a minor component and a degradation product of B and C. Neomycin is a protein synthesis inhibitor and bacteriacidal agent, primarily effective against gram-negative bacteria.
https://pubchem.ncbi.nlm.nih.gov/#query=neomycin
https://www.ncbi.nlm.nih.gov/books/NBK560603
This is any condition in which the main influencing factor is Parabacteroides distasonis, an anaerobic, gram-negative bacillus of the CFB group of bacteria. P. distasonis is an aerotolerant anaerobe found in the gastrointestinal tract of numerous species.
slaulederkind
2024-01-05T12:24:25Z
MESH:C000641579
Bacteroides distasonis
experimental_condition_ontology
XCO:0001211
Parabacteroides distasonis
XCO:0001211
This is any condition in which the main influencing factor is Parabacteroides distasonis, an anaerobic, gram-negative bacillus of the CFB group of bacteria. P. distasonis is an aerotolerant anaerobe found in the gastrointestinal tract of numerous species.
NCBI:txid823
PMID:33790226
This is any condition in which the main influencing factor is bacteria, any of a domain of chiefly round, spiral, or rod-shaped single-celled prokaryotic microorganisms that are represented in most ecological niches on earth.
slaulederkind
2024-01-05T13:06:43Z
NCBI:txid2
experimental_condition_ontology
XCO:0001212
bacteria
XCO:0001212
This is any condition in which the main influencing factor is bacteria, any of a domain of chiefly round, spiral, or rod-shaped single-celled prokaryotic microorganisms that are represented in most ecological niches on earth.
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is Parabacteroides johnsonii, an anaerobic, gram-negative bacillus of the CFB group of bacteria. P. johnsonii is an anaerobe isolated from human fecal matter.
slaulederkind
2024-01-05T14:08:16Z
NCBI:txid387661
PMID:33790226
M-165T
Parabacteroides johnsonii M-165
experimental_condition_ontology
XCO:0001213
Parabacteroides johnsonii
XCO:0001213
This is any condition in which the main influencing factor is Parabacteroides johnsonii, an anaerobic, gram-negative bacillus of the CFB group of bacteria. P. johnsonii is an anaerobe isolated from human fecal matter.
PMID:17267966
https://en.wikipedia.org/wiki/Parabacteroides_johnsonii
This is any condition in which the main influencing factor is reverse osmosis-filtered water, purified water that has sediment and chlorine removed from it with a prefilter before solutes are removed by a semipermeable membrane. Reverse osmosis-filtered water also passes through a postfilter after the semi-permeable membrane.
slaulederkind
2024-01-05T14:27:10Z
PMID:33790226
RO-filtered H2O
RO-filtered water
experimental_condition_ontology
XCO:0001214
reverse osmosis-filtered water
XCO:0001214
This is any condition in which the main influencing factor is reverse osmosis-filtered water, purified water that has sediment and chlorine removed from it with a prefilter before solutes are removed by a semipermeable membrane. Reverse osmosis-filtered water also passes through a postfilter after the semi-permeable membrane.
https://www.freshwatersystems.com/blogs/blog/what-is-reverse-osmosis#1
This is any condition in which the main influencing factor is a drink made up of reverse osmosis-filtered water and a specified amount of fructose consumed by an organism as part of an experiment. Fructose is one of three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion.
slaulederkind
2024-01-05T16:06:22Z
PMID:33790226
controlled fructose content RO-filtered drinking water
experimental_condition_ontology
XCO:0001215
controlled fructose content reverse osmosis-filtered drinking water
XCO:0001215
This is any condition in which the main influencing factor is a drink made up of reverse osmosis-filtered water and a specified amount of fructose consumed by an organism as part of an experiment. Fructose is one of three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion.
https://www.freshwatersystems.com/blogs/blog/what-is-reverse-osmosis#1
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of glucose consumed by a subject. Glucose is a monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues. Glucose is one of the three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion
slaulederkind
2024-01-05T16:23:57Z
PMID:33790226
controlled dextrose content drinking water
experimental_condition_ontology
XCO:0001216
controlled glucose content drinking water
XCO:0001216
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of glucose consumed by a subject. Glucose is a monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues. Glucose is one of the three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is a drink made up of reverse osmosis-filtered water and a specified amount of glucose consumed by an organism as part of an experiment. Glucose is one of three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion.
slaulederkind
2024-01-05T16:40:50Z
PMID:33790226
controlled dextrose content reverse osmosis-filtered drinking water
controlled glucose content RO-filtered drinking water
experimental_condition_ontology
XCO:0001217
controlled glucose content reverse osmosis-filtered drinking water
XCO:0001217
This is any condition in which the main influencing factor is a drink made up of reverse osmosis-filtered water and a specified amount of glucose consumed by an organism as part of an experiment. Glucose is one of three dietary monosaccharides, along with fructose and galactose, that are absorbed directly into the bloodstream during digestion.
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of ampicillin, a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.
slaulederkind
2024-01-05T16:56:23Z
CHEBI:28971
MESH:D000667
controlled aminobenzylpenicillin content drinking water
experimental_condition_ontology
XCO:0001218
controlled ampicillin content drinking water
XCO:0001218
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of ampicillin, a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.
CID:6249
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is a medium-chain triglyceride-containing ketogenic diet (MCTKD), a solid diet with a specific ratio of fat weight to carbohydrate plus protein weight. MCTKDs with different ketogenic ratios are designated by KR values. Medium chain triglycerides are absorbed and transported more efficiently than other types of fat in the diet and yield more ketones produced in the liver per unit of dietary energy.
slaulederkind
2024-01-08T14:26:56Z
KD
ketogenic diet
MCT-KD
MCTKD
experimental_condition_ontology
XCO:0001219
medium-chain triglyceride-containing ketogenic diet
XCO:0001219
This is any condition in which the main influencing factor is a medium-chain triglyceride-containing ketogenic diet (MCTKD), a solid diet with a specific ratio of fat weight to carbohydrate plus protein weight. MCTKDs with different ketogenic ratios are designated by KR values. Medium chain triglycerides are absorbed and transported more efficiently than other types of fat in the diet and yield more ketones produced in the liver per unit of dietary energy.
PMID:36386439
This is any condition in which the main influencing factor is a medium-chain triglyceride-containing ketogenic diet (MCTKD), KR 2.0, a solid diet with a specific ratio of fat weight to carbohydrate plus protein weight of approximately 2.0. A diet with a higher KR ratio delivers more fat than a diet with a lower KR.
slaulederkind
2024-01-08T14:47:02Z
MCT-KD, KR 2.0
MCTKD, KR 2.0
medium-chain triglyceride-containing ketogenic diet, ketogenic ratio 2.0
experimental_condition_ontology
XCO:0001220
medium-chain triglyceride-containing ketogenic diet, KR 2.0
XCO:0001220
This is any condition in which the main influencing factor is a medium-chain triglyceride-containing ketogenic diet (MCTKD), KR 2.0, a solid diet with a specific ratio of fat weight to carbohydrate plus protein weight of approximately 2.0. A diet with a higher KR ratio delivers more fat than a diet with a lower KR.
PMID:36386439
This is any condition in which the main influencing factor is a medium-chain triglyceride-containing ketogenic diet (MCTKD), KR 1.4, a solid diet with a specific ratio of fat weight to carbohydrate plus protein weight of approximately 1.4. A diet with a higher KR ratio delivers more fat than a diet with a lower KR.
slaulederkind
2024-01-08T14:54:32Z
MCT-KD, KR 1.4
MCTKD, KR 1.4
medium-chain triglyceride-containing ketogenic diet, ketogenic ratio 1.4
experimental_condition_ontology
XCO:0001221
medium-chain triglyceride-containing ketogenic diet, KR 1.4
XCO:0001221
This is any condition in which the main influencing factor is a medium-chain triglyceride-containing ketogenic diet (MCTKD), KR 1.4, a solid diet with a specific ratio of fat weight to carbohydrate plus protein weight of approximately 1.4. A diet with a higher KR ratio delivers more fat than a diet with a lower KR.
PMID:36386439
This is any condition in which the main influencing factor is ritonavir, a CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS. Ritonavir is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Ritonavir is also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir for treatment of chronic hepatitis C virus genotype 1 infection and cirrhosis of the liver.
slaulederkind
2024-01-08T15:19:08Z
CID:392622
MESH:D019438
N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
experimental_condition_ontology
XCO:0001222
ritonavir
XCO:0001222
This is any condition in which the main influencing factor is ritonavir, a CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS. Ritonavir is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Ritonavir is also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir for treatment of chronic hepatitis C virus genotype 1 infection and cirrhosis of the liver.
CHEBI:45409
This is any condition in which the main influencing factor is sitaxentan, a drug designed for the treatment of pulmonary arterial hypertension (PAH). The use of sitaxentan was discontinued because of the side effect of hepatotoxicity.
slaulederkind
2024-01-08T15:28:14Z
CHEBI:135736
experimental_condition_ontology
XCO:0001223
sitaxentan
XCO:0001223
This is any condition in which the main influencing factor is sitaxentan, a drug designed for the treatment of pulmonary arterial hypertension (PAH). The use of sitaxentan was discontinued because of the side effect of hepatotoxicity.
CID:216235
This is any condition in which the main influencing factor is sudoxicam, a benzothiazine derivative and non-steroidal anti-inflammatory drug. Sudoxicam also has anti-edema and antipyretic activity.
slaulederkind
2024-01-09T14:26:00Z
CID:54682951
MESH:C100301
experimental_condition_ontology
XCO:0001224
sudoxicam
XCO:0001224
This is any condition in which the main influencing factor is sudoxicam, a benzothiazine derivative and non-steroidal anti-inflammatory drug. Sudoxicam also has anti-edema and antipyretic activity.
https://www.medchemexpress.com/sudoxicam.html
https://www.scbt.com/p/sudoxicam-34042-85-8
This is any condition in which the main influencing factor is sumatriptan, a serotonin agonist that acts selectively at 5HT1 receptors. It i s used for the acute treatment of migraine with or without aura in adults.
slaulederkind
2024-01-09T14:36:52Z
MESH:D018170
1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide
Imitrex
experimental_condition_ontology
XCO:0001225
sumatriptan
XCO:0001225
This is any condition in which the main influencing factor is sumatriptan, a serotonin agonist that acts selectively at 5HT1 receptors. It i s used for the acute treatment of migraine with or without aura in adults.
CHEBI:10650
CID:5358
This is any condition in which the main influencing factor is tacrine, a centerally active cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine is also a histamine N-methyltransferase inhibitor.
slaulederkind
2024-01-09T14:46:59Z
CHEBI:45980
CID:1935
experimental_condition_ontology
XCO:0001226
tacrine
XCO:0001226
This is any condition in which the main influencing factor is tacrine, a centerally active cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine is also a histamine N-methyltransferase inhibitor.
MESH:D013619
This is any condition in which the main influencing factor is teriparatide, a recombinant human parathyroid hormone analogue that is used to treat osteoporosis in women or men with a high risk for bone fracture. Teriparatide is made up of the first amino(N)-terminal 34 amino acids of human PTH (parathyroid hormone) and is an osteoanabolic agent.
slaulederkind
2024-01-09T15:24:19Z
CHEBI:135983
GSE121109
PTH (1-34)
TPTD
human PTH (1-34)
experimental_condition_ontology
XCO:0001227
teriparatide
XCO:0001227
This is any condition in which the main influencing factor is teriparatide, a recombinant human parathyroid hormone analogue that is used to treat osteoporosis in women or men with a high risk for bone fracture. Teriparatide is made up of the first amino(N)-terminal 34 amino acids of human PTH (parathyroid hormone) and is an osteoanabolic agent.
SID:483927060
This is any condition in which the main influencing factor is electrical muscle stimulation (EMS), a transcutaneous method of stimulating skeletal muscle. EMS is designed to facilitate passive activation of a large number of motor units and induce synchronous recruitment of muscle fibers, with the aim of strengthening or maintaining muscle mass.
slaulederkind
2024-01-11T14:53:45Z
PMID:30933441
EMS
experimental_condition_ontology
XCO:0001228
electrical muscle stimulation
XCO:0001228
This is any condition in which the main influencing factor is electrical muscle stimulation (EMS), a transcutaneous method of stimulating skeletal muscle. EMS is designed to facilitate passive activation of a large number of motor units and induce synchronous recruitment of muscle fibers, with the aim of strengthening or maintaining muscle mass.
PMID:36705372
This is any condition in which the main influencing factor is Baihu-Guizhi decoction, an anti-arthritic drug of traditional Chinese medicine (TCM). Baihu-Guizhi decoction (BHGZD) is extensively used for the treatment of rheumatoid arthritis (RA).
slaulederkind
2024-01-11T15:21:04Z
PMID:35799788
PMID:36195951
BHGZD
experimental_condition_ontology
XCO:0001229
Baihu-Guizhi decoction
XCO:0001229
This is any condition in which the main influencing factor is Baihu-Guizhi decoction, an anti-arthritic drug of traditional Chinese medicine (TCM). Baihu-Guizhi decoction (BHGZD) is extensively used for the treatment of rheumatoid arthritis (RA).
PMID:34675809
This is any condition in which the main influencing factor is Imwitor 742, a blend of mono-, di- and triglycerides, mainly of caprylic and capric acid. Imwitor 742 acts as a solubilizer for poorly soluble drugs in oral administration forms (i.e. capsules), as a penetration enhancer in topical drug forms, and as a co-emulsifier in emulsions.
slaulederkind
2024-01-11T16:07:16Z
PMID:32119089
Glycerol Monocaprylocaprate, type I
Glyceryl Mono- and Dicaprylocaprate
experimental_condition_ontology
XCO:0001230
Imwitor 742
XCO:0001230
This is any condition in which the main influencing factor is Imwitor 742, a blend of mono-, di- and triglycerides, mainly of caprylic and capric acid. Imwitor 742 acts as a solubilizer for poorly soluble drugs in oral administration forms (i.e. capsules), as a penetration enhancer in topical drug forms, and as a co-emulsifier in emulsions.
https://marcordev.com/wp-content/uploads/2020/07/IMWITOR_742_TDSH-1.pdf
This is any condition in which the main influencing factor is a solvent, a liquid that can dissolve other substances (solutes) without any change in their chemical composition.
slaulederkind
2024-01-11T16:13:49Z
MESH:D012997
solvents
experimental_condition_ontology
XCO:0001231
solvent
XCO:0001231
This is any condition in which the main influencing factor is a solvent, a liquid that can dissolve other substances (solutes) without any change in their chemical composition.
CHEBI:46787
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is an emulsifier, a surface-active agent (such as a soap) promoting the formation and stabilization of an emulsion (a fine dispersion of minute droplets of one liquid in another in which it is not soluble).
slaulederkind
2024-01-11T16:29:53Z
CHEBI:63046
PMID:32119089
experimental_condition_ontology
XCO:0001232
emulsifier
XCO:0001232
This is any condition in which the main influencing factor is an emulsifier, a surface-active agent (such as a soap) promoting the formation and stabilization of an emulsion (a fine dispersion of minute droplets of one liquid in another in which it is not soluble).
https://languages.oup.com/google-dictionary-en/
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is telcagepant, a calcitonin gene-related peptide (CGRP) receptor antagonist which was an investigational drug for the acute treatment and prevention of migraine. Development of telcagepant was discontinued due to hepatic side effects.
slaulederkind
2024-01-12T11:09:21Z
CID:11319053
MK-0974
MK0974
N-[(3R,6S)-6-(2,3-Difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-azepin-3-yl]-4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxamide
experimental_condition_ontology
XCO:0001233
telcagepant
XCO:0001233
This is any condition in which the main influencing factor is telcagepant, a calcitonin gene-related peptide (CGRP) receptor antagonist which was an investigational drug for the acute treatment and prevention of migraine. Development of telcagepant was discontinued due to hepatic side effects.
https://en.wikipedia.org/wiki/Telcagepant
This is any condition in which the main influencing factor is telithromycin, a semi-synthetic erythromycin derivative which belongs to a new chemical class of antibiotics called ketolides. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis.
slaulederkind
2024-01-12T11:21:08Z
CHEBI:29688
MESH:C106791
Ketek
experimental_condition_ontology
XCO:0001234
telithromycin
XCO:0001234
This is any condition in which the main influencing factor is telithromycin, a semi-synthetic erythromycin derivative which belongs to a new chemical class of antibiotics called ketolides. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis.
CID:3002190
This is any condition in which the main influencing factor is tetracycline, a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. Tetracycline is both an antibacterial and antiprotozoal drug.
slaulederkind
2024-01-12T12:11:59Z
CHEBI:27902
MESH:D013752
(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
experimental_condition_ontology
XCO:0001235
tetracycline
XCO:0001235
This is any condition in which the main influencing factor is tetracycline, a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. Tetracycline is both an antibacterial and antiprotozoal drug.
CID:54675776
This is any condition whose main influencing factor is Morinda officinalis polysaccharide, a crude polysaccharide extract from the root of Morinda officinalis, a plant used in traditional Chinese medicine.
slaulederkind
2024-01-12T13:30:17Z
PMID:34466146
M. officinalis polysaccharide
MOP
Morinda officinalis polysaccharides
MOP-100
MOP-60
experimental_condition_ontology
XCO:0001236
Morinda officinalis polysaccharide
XCO:0001236
This is any condition whose main influencing factor is Morinda officinalis polysaccharide, a crude polysaccharide extract from the root of Morinda officinalis, a plant used in traditional Chinese medicine.
PMID:31465803
This is any condition whose main influencing factor is an experimental varicocele generated by partial ligation of the left renal vein. A varicocele is an abnormal dilation of the pampiniform plexus (veins) of the spermatic cord..
slaulederkind
2024-01-12T13:50:18Z
PMID:28138407
experimental_condition_ontology
XCO:0001237
experimental varicocele
XCO:0001237
This is any condition whose main influencing factor is an experimental varicocele generated by partial ligation of the left renal vein. A varicocele is an abnormal dilation of the pampiniform plexus (veins) of the spermatic cord..
ISBN-13:978-1455756438
PMID:34466146
This is any condition in which the main influencing factor is ticlopidine, an inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation.
slaulederkind
2024-01-12T18:37:58Z
CHEBI:9588
MESH:D013988
5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
experimental_condition_ontology
XCO:0001238
ticlopidine
XCO:0001238
This is any condition in which the main influencing factor is ticlopidine, an inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation.
CID:5472
This is any condition in which the main influencing factor is gefitinib, an EGFR (epidermal growth factor receptor) tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer.
slaulederkind
2024-01-15T13:18:12Z
CID:123631
MESH:D000077156
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
ZD1839
experimental_condition_ontology
XCO:0001239
gefitinib
XCO:0001239
This is any condition in which the main influencing factor is gefitinib, an EGFR (epidermal growth factor receptor) tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer.
CHEBI:49668
This is any condition in which the main influencing factor is afatinib, an inhibitor of epidermal growth factor receptor (EGFR, ERBB2, ERBB3, ERBB4) tyrosine kinases used for the treatment of metastatic non-small cell lung cancer.
slaulederkind
2024-01-15T13:43:35Z
CHEBI:61390
CID:10184653
(2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
experimental_condition_ontology
XCO:0001240
afatinib
XCO:0001240
This is any condition in which the main influencing factor is afatinib, an inhibitor of epidermal growth factor receptor (EGFR, ERBB2, ERBB3, ERBB4) tyrosine kinases used for the treatment of metastatic non-small cell lung cancer.
MESH:D000077716
This is any condition in which the main influencing factor is tienilic acid, a loop diuretic with uricosuric action. Tienilic acid was marketed for the treatment of hypertension until being withdrawn in 1982 because of reports of hepatotoxicity.
slaulederkind
2024-01-15T15:48:27Z
CHEBI:9590
MESH:D013989
[2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid
ticrynafen
experimental_condition_ontology
XCO:0001241
tienilic acid
XCO:0001241
This is any condition in which the main influencing factor is tienilic acid, a loop diuretic with uricosuric action. Tienilic acid was marketed for the treatment of hypertension until being withdrawn in 1982 because of reports of hepatotoxicity.
CID:38409
This is any condition in which the main influencing factor is tolcapone, a catechol O-methyltransferase (COMT) inhibitor used in the treatment of Parkinson disease.
slaulederkind
2024-01-15T16:12:42Z
CHEBI:63630
CID:4659569
(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
experimental_condition_ontology
XCO:0001242
tolcapone
XCO:0001242
This is any condition in which the main influencing factor is tolcapone, a catechol O-methyltransferase (COMT) inhibitor used in the treatment of Parkinson disease.
MESH:D000077867
This is any condition in which the major influencing factor is wind, the movement of air of any velocity, especially an experimentally controlled velocity. The air may be ambient or otherwise controlled.
slaulederkind
2024-01-16T13:30:43Z
PMID:35799788
experimental_condition_ontology
XCO:0001243
wind
XCO:0001243
This is any condition in which the major influencing factor is wind, the movement of air of any velocity, especially an experimentally controlled velocity. The air may be ambient or otherwise controlled.
https://www.merriam-webster.com/
This is any condition in which the major influencing factor is the ambient environment, an encompassing atmosphere which includes temperature, light, sound, and air content as parameters.
slaulederkind
2024-01-16T13:50:10Z
atmosphere
experimental_condition_ontology
XCO:0001244
ambient environment
XCO:0001244
This is any condition in which the major influencing factor is the ambient environment, an encompassing atmosphere which includes temperature, light, sound, and air content as parameters.
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is an antiemetic, a drug used to prevent nausea or vomiting. An antiemetic may affect the medullary control centers (the vomiting center and the chemoreceptive trigger zone) or peripheral receptors.
slaulederkind
2024-01-16T14:27:16Z
D000932
https://www.merriam-webster.com/dictionary/antiemetic
experimental_condition_ontology
XCO:0001245
antiemetic
XCO:0001245
This is any condition in which the main influencing factor is an antiemetic, a drug used to prevent nausea or vomiting. An antiemetic may affect the medullary control centers (the vomiting center and the chemoreceptive trigger zone) or peripheral receptors.
CHEBI:50919
This is any condition in which the main influencing factor is trimethobenzamide, a drug used to prevent nausea and vomiting in humans.
slaulederkind
2024-01-16T14:35:01Z
CID:5577
MESH:C100146
N-{4-[2-(dimethylamino)ethoxy]benzyl}-3,4,5-trimethoxybenzamide
experimental_condition_ontology
XCO:0001246
trimethobenzamide
XCO:0001246
This is any condition in which the main influencing factor is trimethobenzamide, a drug used to prevent nausea and vomiting in humans.
CHEBI:27796
This is any condition in which the main influencing factor is sterile water, which is high quality water used for medical irrigation, injection, or inhalation and has been prepared to eliminate microbial contamination. Sterile water may be used as a pharmaceutical solvent.
slaulederkind
2024-01-16T14:59:01Z
sterile H2O
experimental_condition_ontology
XCO:0001247
sterile water
XCO:0001247
This is any condition in which the main influencing factor is sterile water, which is high quality water used for medical irrigation, injection, or inhalation and has been prepared to eliminate microbial contamination. Sterile water may be used as a pharmaceutical solvent.
https://www.merriam-webster.com/
https://www.rxlist.com/sterile-water-drug.htm
This is any condition in which the main influencing factor is poloxamers, nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The length of the copolymer chains can be varied to alter the properties of the whole molecule.
slaulederkind
2024-01-16T15:27:53Z
MESH:D020442
PMID:32119089
Kolliphors
Pluronics
Synperonics
experimental_condition_ontology
XCO:0001248
poloxamers
XCO:0001248
This is any condition in which the main influencing factor is poloxamers, nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The length of the copolymer chains can be varied to alter the properties of the whole molecule.
https://en.wikipedia.org/wiki/Poloxamer
This is any condition in which the main influencing factor is Poloxamer 407 (P407), a nonionic triblock copolymer with a polyoxypropylene molecular mass of 4000 g/mol and a 70% polyoxyethylene content. P407 is used as an emulsifying agent and solubilizing agent in cosmetic and personal products.
slaulederkind
2024-01-16T16:33:41Z
P407
experimental_condition_ontology
XCO:0001249
Poloxamer 407
XCO:0001249
This is any condition in which the main influencing factor is Poloxamer 407 (P407), a nonionic triblock copolymer with a polyoxypropylene molecular mass of 4000 g/mol and a 70% polyoxyethylene content. P407 is used as an emulsifying agent and solubilizing agent in cosmetic and personal products.
CID:24751
https://en.wikipedia.org/wiki/Poloxamer
This is any condition in which the main influencing factor is Poria cocos, a fungus used extensively as a medicinal mushroom in traditional Chinese medicine.
slaulederkind
2024-01-18T13:48:59Z
China root
Macrohyporia cocos
Macrohyporia extensa
PC
Wolfiporia cocos
Wolfiporia extensa
fu ling
hoelen
matsuhodo
poria
tuckahoe
experimental_condition_ontology
XCO:0001250
Poria cocos
XCO:0001250
This is any condition in which the main influencing factor is Poria cocos, a fungus used extensively as a medicinal mushroom in traditional Chinese medicine.
https://en.wikipedia.org/wiki/Wolfiporia_extensa
This is any condition in which the main influencing factor is Alismatis rhizoma, the rhizomes of A. orientale (Alisma orientale, a flowering plant species found in Asia) which have been used as a traditional Chinese medicine and as a kampo Japanese medicine. Terpenoids have been identified as characteristic constituents of Alisma orientale.
slaulederkind
2024-01-18T14:09:22Z
CHEBI:26873
PMID:27080939
AR
Alisma orientale (Sam.) Juzep rhizomes
Asian water plantain
experimental_condition_ontology
XCO:0001251
Alismatis rhizoma
XCO:0001251
This is any condition in which the main influencing factor is Alismatis rhizoma, the rhizomes of A. orientale (Alisma orientale, a flowering plant species found in Asia) which have been used as a traditional Chinese medicine and as a kampo Japanese medicine. Terpenoids have been identified as characteristic constituents of Alisma orientale.
https://en.wikipedia.org/wiki/Alisma_orientale
This is any condition in which the main influencing factor is PC-AR, an extract derived from a 60%-40% mix (by weight) of Poria cocos and Alismatis rhizoma.
slaulederkind
2024-01-18T15:11:22Z
Poria cocos-Alismatis rhizoma
aqueous extract of Poria cocos-Alismatis rhizoma
experimental_condition_ontology
XCO:0001252
PC-AR
XCO:0001252
This is any condition in which the main influencing factor is PC-AR, an extract derived from a 60%-40% mix (by weight) of Poria cocos and Alismatis rhizoma.
PMID:37840052
This is any condition in which the main influencing factor is Huatan Jiangzhuo decoction, a combination of six traditional Chinese medicines that is used for lipid metabolism-related disorders.
slaulederkind
2024-01-18T15:29:08Z
PMID:33936248
HJD
HTJZD
experimental_condition_ontology
XCO:0001253
Huatan Jiangzhuo decoction
XCO:0001253
This is any condition in which the main influencing factor is Huatan Jiangzhuo decoction, a combination of six traditional Chinese medicines that is used for lipid metabolism-related disorders.
PMID:33641781
This is any condition in which the main influencing factor is troglitazone, a hypoglycemic agent that was taken off the market due to hepatotoxicity issues. Troglitazone is also an antioxidant, a vasodilator agent, an anticonvulsant, an anticoagulant, an antineoplastic agent, and a long-chain-fatty-acid--CoA ligase inhibitor.
slaulederkind
2024-01-19T10:41:51Z
CHEBI:9753
MESH:D000077288
PMID:32119089
5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
experimental_condition_ontology
XCO:0001254
troglitazone
XCO:0001254
This is any condition in which the main influencing factor is indomethacin, a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate acute pain and relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis) or gout. Indomethacin also inhibits the motility of polymorphonuclear leukocytes.
slaulederkind
2024-01-19T10:58:34Z
CHEBI:49662
CID:3715
[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
indometacin
experimental_condition_ontology
XCO:0001255
indomethacin
XCO:0001255
This is any condition in which the main influencing factor is indomethacin, a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate acute pain and relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis) or gout. Indomethacin also inhibits the motility of polymorphonuclear leukocytes.
MESH:D007213
https://www.mayoclinic.org/drugs-supplements/indomethacin-oral-route/description/drg-20069700
This is any condition in which the main influencing factor is total parenteral nutrition (TPN), a method of feeding that bypasses the gastrointestinal tract by using an intravenous route. Total parenteral nutrition exists when no significant nutrition is obtained by other routes.
slaulederkind
2024-01-19T11:31:20Z
PMID:32644462
TNA
TPN
total nutrient admixture
CVN
central venous nutrition
peripheral parenteral nutrition
experimental_condition_ontology
XCO:0001256
total parenteral nutrition
XCO:0001256
This is any condition in which the main influencing factor is total parenteral nutrition (TPN), a method of feeding that bypasses the gastrointestinal tract by using an intravenous route. Total parenteral nutrition exists when no significant nutrition is obtained by other routes.
https://en.wikipedia.org/wiki/Parenteral_nutrition
https://medlineplus.gov/ency/patientinstructions/000177.htm
This is any condition in which the main influencing factor is trovafloxacin, a broad spectrum antibiotic more effective against Gram-positive bacteria than Gram-negative bacteria. Trovafloxacin exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA by blocking the activity of DNA gyrase and topoisomerase IV.
slaulederkind
2024-01-19T13:03:35Z
CHEBI:9763
MESH:C080163
7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
TVFX
experimental_condition_ontology
XCO:0001257
trovafloxacin
XCO:0001257
This is any condition in which the main influencing factor is trovafloxacin, a broad spectrum antibiotic more effective against Gram-positive bacteria than Gram-negative bacteria. Trovafloxacin exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA by blocking the activity of DNA gyrase and topoisomerase IV.
CID:62959
This is any condition in which the main influencing factor is valproate, a branched-chain saturated fatty acid anion that is the conjugate base of valproic acid. Valproic acid is used in the treatment of epilepsy and bipolar disorder.
slaulederkind
2024-01-22T09:34:42Z
CHEBI:60654
2-propylpentanoate
VPA
experimental_condition_ontology
XCO:0001258
valproate
XCO:0001258
This is any condition in which the main influencing factor is valproate, a branched-chain saturated fatty acid anion that is the conjugate base of valproic acid. Valproic acid is used in the treatment of epilepsy and bipolar disorder.
CID:3549980
This is any condition in which the main influencing factor is valsartan, a monocarboxylic acid amide and angiotensin II type 1 receptor blocker that is used to treat hypertension. Valsartan is also used in the management of heart failure and type 2 diabetes-associated nephropathy.
slaulederkind
2024-01-22T09:54:58Z
CHEBI:9927
N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-L-valine
experimental_condition_ontology
XCO:0001259
valsartan
XCO:0001259
This is any condition in which the main influencing factor is valsartan, a monocarboxylic acid amide and angiotensin II type 1 receptor blocker that is used to treat hypertension. Valsartan is also used in the management of heart failure and type 2 diabetes-associated nephropathy.
CID:60846
MESH:D000068756
This is any condition in which the main influencing factor is pH-adjusted sterile water, an acidity- or alkalinity-adjusted sterile water that is equilibrated to a specific pH.
slaulederkind
2024-01-22T11:22:07Z
sterile H2O, pH-adjusted
experimental_condition_ontology
XCO:0001260
sterile water, pH-adjusted
XCO:0001260
This is any condition in which the main influencing factor is pH-adjusted sterile water, an acidity- or alkalinity-adjusted sterile water that is equilibrated to a specific pH.
https://www.merriam-webster.com
https://www.rxlist.com/sterile-water-drug.htm
This is any condition in which the main influencing factor is Ma Xing Shi Gan decoction, an anti-inflammatory and antiviral drug of traditional Chinese medicine (TCM). Ma Xing Shi Gan decoction has shown some effectiveness in the treatment of COVID-19 infection.
slaulederkind
2024-01-22T13:02:45Z
PMID:32360484
MXSG
MXSG Decoction
Maxing Shigan Decoction
Maxingshigan Decoction
experimental_condition_ontology
XCO:0001261
Ma Xing Shi Gan decoction
XCO:0001261
This is any condition in which the main influencing factor is Ma Xing Shi Gan decoction, an anti-inflammatory and antiviral drug of traditional Chinese medicine (TCM). Ma Xing Shi Gan decoction has shown some effectiveness in the treatment of COVID-19 infection.
PMID:33324213
This is any condition in which the main influencing factor is ximelagatran, which is an anticoagulant, a serine protease inhibitor and a prodrug for melagatran.
slaulederkind
2024-01-23T11:32:13Z
CHEBI:65172
MESH:C426686
ethyl N-{(1R)-1-cyclohexyl-2-[(2S)-2-{[4-(N'-hydroxycarbamimidoyl)benzyl]carbamoyl}azetidin-1-yl]-2-oxoethyl}glycinate
experimental_condition_ontology
XCO:0001262
ximelagatran
XCO:0001262
This is any condition in which the main influencing factor is ximelagatran, which is an anticoagulant, a serine protease inhibitor and a prodrug for melagatran.
CID:9574101
This is any condition in which the main influencing factor is zafirlukast, a leukotriene receptor antagonist (LTRA) and cytochrome P450 2C9 (CYP2C9) inhibitor.
slaulederkind
2024-01-23T13:19:13Z
CHEBI:10100
MESH:C062735
cyclopentyl 3-[2-methoxy-4-(2-methylphenylsulfonylcarbamoyl)benzyl]-1-methyl-1H-indol-5-ylcarbamate
experimental_condition_ontology
XCO:0001263
zafirlukast
XCO:0001263
This is any condition in which the main influencing factor is zafirlukast, a leukotriene receptor antagonist (LTRA) and cytochrome P450 2C9 (CYP2C9) inhibitor.
CID:5717
This is any condition in which the main influencing factor is phloretin, an antineoplastic agent and natural dihydrochalcone found in many fruits.
slaulederkind
2024-01-23T13:32:00Z
CHEBI:17276
MESH:D010693
PMID:36793870
3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
PHL
experimental_condition_ontology
XCO:0001264
phloretin
XCO:0001264
This is any condition in which the main influencing factor is phloretin, an antineoplastic agent and natural dihydrochalcone found in many fruits.
CID:4788
This is any condition in which the main influencing factor is stress, which is a physical, chemical, or emotional factor that causes bodily or mental tension and may be a factor in disease causation.
slaulederkind
2024-01-23T14:18:33Z
pressure
strain
tension
experimental_condition_ontology
XCO:0001265
stress
XCO:0001265
This is any condition in which the main influencing factor is stress, which is a physical, chemical, or emotional factor that causes bodily or mental tension and may be a factor in disease causation.
https://www.merriam-webster.com
This is any condition in which the main influencing factor is cage tilt, a procedure designed to cause mild stress in laboratory animals. Typically, the cage is tilted at 30 - 45 degrees for a few hours at a time to overnight.
slaulederkind
2024-01-23T14:47:18Z
PMID:34568850
cage tilt stress
experimental_condition_ontology
XCO:0001266
cage tilt
XCO:0001266
This is any condition in which the main influencing factor is cage tilt, a procedure designed to cause mild stress in laboratory animals. Typically, the cage is tilted at 30 - 45 degrees for a few hours at a time to overnight.
PMID:26650668
https://www.merriam-webster.com
This is any condition in which the main influencing factor is a reversed light/dark cycle, a light/dark cycle that is opposite of the normal day/night conditions the subject or patient experiences.
slaulederkind
2024-01-23T15:27:16Z
PMID:36793870
reverse day/night lighting
reversed day/night lighting
reversed light/dark cycle
continuous lighting
partially reversed day/night lighting
experimental_condition_ontology
XCO:0001267
reversed light/dark cycle
XCO:0001267
This is any condition in which the main influencing factor is a reversed light/dark cycle, a light/dark cycle that is opposite of the normal day/night conditions the subject or patient experiences.
https://www.merriam-webster.com
This is any condition in which the main influencing factor is a tail clip procedure, a procedure done in the process of collecting blood from a laboratory animal. The subject is usually lightly restrained by the handler or by a mechancal device, while a few millimeters is cut off the end of the tail.
slaulederkind
2024-01-23T16:02:29Z
PMID:36793870
tail snip
tail-clip
experimental_condition_ontology
XCO:0001268
tail clip
XCO:0001268
This is any condition in which the main influencing factor is a tail clip procedure, a procedure done in the process of collecting blood from a laboratory animal. The subject is usually lightly restrained by the handler or by a mechancal device, while a few millimeters is cut off the end of the tail.
PMID:18459706
This is any condition in which the main influencing factor is forced swimming, a situation in which the subject (typically a laboratory rodent) inside a water-filled cylinder must swim to survive.
slaulederkind
2024-01-23T16:19:18Z
PMID:26650668
PMID:36793870
FST
Porsolt forced swimming test
behavioural despair test
forced swim test
forced swimming test
experimental_condition_ontology
XCO:0001269
forced swimming
XCO:0001269
This is any condition in which the main influencing factor is forced swimming, a situation in which the subject (typically a laboratory rodent) inside a water-filled cylinder must swim to survive.
https://www.merriam-webster.com
This is any condition in which the main influencing factor is forced swimming in cold water, a situation in which the subject (typically a laboratory rodent), inside a water-filled cylinder, must swim to survive.
slaulederkind
2024-01-23T16:31:48Z
cold water FST
forced cold water swim
forced cold water swim test
forced cold water swimming test
experimental_condition_ontology
XCO:0001270
forced cold water swimming
XCO:0001270
This is any condition in which the main influencing factor is forced swimming in cold water, a situation in which the subject (typically a laboratory rodent), inside a water-filled cylinder, must swim to survive.
PMID:36793870
https://en.wikipedia.org/wiki/Behavioural_despair_test
This is any condition in which the main influencing factor is zimelidine, an SRI (serotonin uptake inhibitor) antidepressant whose use was discontinued because of the risk of Guillain-Barre syndrome as a side effect.
slaulederkind
2024-01-25T09:24:24Z
CAS:56775-88-3
CHEBI:135357
MESH:D015031
2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, (Z)-
experimental_condition_ontology
XCO:0001271
zimelidine
XCO:0001271
This is any condition in which the main influencing factor is zimelidine, an SRI (serotonin uptake inhibitor) antidepressant whose use was discontinued because of the risk of Guillain-Barre syndrome as a side effect.
CID:5365247
This is any condition in which the main influencing factor is zolpidem, an imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of insomnia.
slaulederkind
2024-01-25T09:47:44Z
CHEBI:10125
CID:5732
N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
experimental_condition_ontology
XCO:0001272
zolpidem
XCO:0001272
This is any condition in which the main influencing factor is zolpidem, an imidazopyridine derivative and short-acting GABA-A receptor agonist that is used for the treatment of insomnia.
MESH:D000077334
This is any condition in which the main influencing factor is a high-protein/ammoniagenic diet, which is a standard diet supplemented with additional amino acids including leucine (~13% of amino acids), valine (~11% of amino acids), and the absence of isoleucine.
slaulederkind
2024-01-25T12:58:34Z
experimental_condition_ontology
XCO:0001273
high-protein/ammoniagenic diet
XCO:0001273
This is any condition in which the main influencing factor is a high-protein/ammoniagenic diet, which is a standard diet supplemented with additional amino acids including leucine (~13% of amino acids), valine (~11% of amino acids), and the absence of isoleucine.
PMID:10459831
PMID:36539425
This is any condition in which the main influencing factor is telmisartan, a biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist used in the management of hypertension.
slaulederkind
2024-01-25T13:22:29Z
CHEBI:9434
CID:65999
4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
experimental_condition_ontology
XCO:0001274
telmisartan
XCO:0001274
This is any condition in which the main influencing factor is telmisartan, a biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist used in the management of hypertension.
MESH:D000077333
This is any condition in which the main influencing factor is unpredictable chronic mild stress, an experimental model of depression that involves exposing laboratory animals (usually mice or rats) at unpredictable times over several weeks to a series of minor-intensity stressors. This process results in the development of a number of behavioral alterations in a large majority of animals, including anhedonia (loss of pleasure) and apathy.
slaulederkind
2024-01-29T12:15:10Z
CMS
CUMS
UCMS
chronic unpredictable mild stress
chronic unpredictable stress
experimental_condition_ontology
XCO:0001275
unpredictable chronic mild stress
XCO:0001275
This is any condition in which the main influencing factor is unpredictable chronic mild stress, an experimental model of depression that involves exposing laboratory animals (usually mice or rats) at unpredictable times over several weeks to a series of minor-intensity stressors. This process results in the development of a number of behavioral alterations in a large majority of animals, including anhedonia (loss of pleasure) and apathy.
PMID:34406704
PMID:7202217
This is any condition in which the main influencing factor is bromobenzene, the simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. Bromobenzene is used as a solvent, particularly for large-scale crystallizations, and for the introduction of phenyl groups in organic synthesis.
slaulederkind
2024-01-30T12:12:23Z
CID:7961
MESH:C032036
Benzene, bromo
Monobromobenzene
PhBr
Phenyl bromide
experimental_condition_ontology
XCO:0001276
bromobenzene
XCO:0001276
This is any condition in which the main influencing factor is bromobenzene, the simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. Bromobenzene is used as a solvent, particularly for large-scale crystallizations, and for the introduction of phenyl groups in organic synthesis.
CHEBI:3179
This is any condition in which the main influencing factor is nicotinamide, a pyridine derivative that is a component of the coenzyme NAD, a form of vitamin B3, an antioxidant, a histone deacetylase inhibitor, and an anti-inflammatory agent.
slaulederkind
2024-01-30T12:34:51Z
vitamin B3
CHEBI:17154
MESH:D009536
3-pyridinecarboxamide
NAM
niacinamide
experimental_condition_ontology
XCO:0001277
nicotinamide
XCO:0001277
This is any condition in which the main influencing factor is nicotinamide, a pyridine derivative that is a component of the coenzyme NAD, a form of vitamin B3, an antioxidant, a histone deacetylase inhibitor, and an anti-inflammatory agent.
CID:936
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of nicotinamide, in which the amount of nicotinamide consumed is maintained at a specified level.
slaulederkind
2024-01-30T12:51:51Z
CHEBI:17154
CID:936
MESH:D009536
controlled NAM content drinking water
controlled niacinamide content drinking water
experimental_condition_ontology
XCO:0001278
controlled nicotinamide content drinking water
XCO:0001278
This is any condition in which the main influencing factor is a drink made up of water and a specified amount of nicotinamide, in which the amount of nicotinamide consumed is maintained at a specified level.
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is partial bladder outlet obstruction, an experimental constriction of the neck of the urinary bladder to restrict urine flow and model changes that occur in clinical bladder outlet obstruction (BOO). Partial bladder outlet obstruction may be achieved surgically by passing a catheter through the urethra into the bladder, suturing around the neck of the bladder, and removing the catheter.
slaulederkind
2024-02-01T10:29:45Z
GSE167430
https://my.clevelandclinic.org/health/diseases/15181-bladder-outlet-obstruction
pBOO
experimental_condition_ontology
XCO:0001279
partial bladder outlet obstruction
XCO:0001279
This is any condition in which the main influencing factor is partial bladder outlet obstruction, an experimental constriction of the neck of the urinary bladder to restrict urine flow and model changes that occur in clinical bladder outlet obstruction (BOO). Partial bladder outlet obstruction may be achieved surgically by passing a catheter through the urethra into the bladder, suturing around the neck of the bladder, and removing the catheter.
PMID:20590549
This is any condition in which the main influencing factor is the open field task, which is designed to measure the movement and other behavior exhibited by a subject responding to an experimentally defined, open space. The open field test is used to assess activity and behavior in laboratory animals, usually rodents.
slaulederkind
2024-02-05T12:42:37Z
PMID:25742564
PMID:36793870
open field maze
open field test
experimental_condition_ontology
XCO:0001280
open field task
XCO:0001280
This is any condition in which the main influencing factor is the open field task, which is designed to measure the movement and other behavior exhibited by a subject responding to an experimentally defined, open space. The open field test is used to assess activity and behavior in laboratory animals, usually rodents.
https://en.wikipedia.org/wiki/Open_field_(animal_test)
https://med.stanford.edu/sbfnl/services/bm/sm/openfield.html
This is any condition in which the main influencing factor is sodium octanoate, an organic sodium salt comprising equal numbers of sodium and octanoate ions.
slaulederkind
2024-02-05T16:24:49Z
CID:23664772
PMID:34939931
octanoic acid, sodium salt
sodium caprylate
sodium n-octanoate
experimental_condition_ontology
XCO:0001281
sodium octanoate
XCO:0001281
This is any condition in which the main influencing factor is sodium octanoate, an organic sodium salt comprising equal numbers of sodium and octanoate ions.
CHEBI:132100
This is any condition in which the main influencing factor is sodium carboxymethylcellulose, a cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. Sodium carboxymethylcellulose is a commonly used form of carboxymethylcellulose.
slaulederkind
2024-02-06T11:57:19Z
CHEBI:85146
CID:6328154
CMC-Na
carboxymethylcellulose sodium
carboxymethylcellulose sodium salt
carmellose sodium
experimental_condition_ontology
XCO:0001282
sodium carboxymethylcellulose
XCO:0001282
This is any condition in which the main influencing factor is sodium carboxymethylcellulose, a cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. Sodium carboxymethylcellulose is a commonly used form of carboxymethylcellulose.
MESH:D002266
https://en.wikipedia.org/wiki/Carboxymethyl_cellulose#References
This is any condition in which the main influencing factor is grouped housing, a living situation involving four or more individual subjects housed in the same structure.
slaulederkind
2024-02-08T16:10:11Z
group housing
experimental_condition_ontology
XCO:0001283
grouped housing
XCO:0001283
This is any condition in which the main influencing factor is grouped housing, a living situation involving four or more individual subjects housed in the same structure.
PMID:15033287
PMID:37044360
This is any condition in which the main influencing factor is a soiled cage, a housing condition designed to create stress in subjects living in such housing. The soiled cage is typically a cage in which excess water has been introduced to the bedding (for example: 200 ml water in 100 g of sawdust bedding).
slaulederkind
2024-02-08T16:47:00Z
wet cage
experimental_condition_ontology
XCO:0001284
soiled cage
XCO:0001284
This is any condition in which the main influencing factor is a soiled cage, a housing condition designed to create stress in subjects living in such housing. The soiled cage is typically a cage in which excess water has been introduced to the bedding (for example: 200 ml water in 100 g of sawdust bedding).
PMID:15033287
PMID:36793870
This is any condition in which the main influencing factor is oxaliplatin, an organoplatinum complex that is a commonly used as a chemothrepeutic drug for treatment of metastatic colorectal cancer.
slaulederkind
2024-02-16T15:16:38Z
GSE160543
(SP-4-2)[(1R,2R)-cyclohexane-1,2-diamine-kappa(2)N,N'][ethanedioato(2-)-kappa(2)O(1),O(2)]platinum
experimental_condition_ontology
XCO:0001285
oxaliplatin
XCO:0001285
This is any condition in which the main influencing factor is oxaliplatin, an organoplatinum complex that is a commonly used as a chemothrepeutic drug for treatment of metastatic colorectal cancer.
XCO:0000088
This is any condition in which the main influencing factor is a Von Frey monofilament stimulus, usually encountered in a Von Frey assay, which is used to evaluate mechanical allodynia in laboratory rodents. The von Frey test, which may be manual or electronic, uses von Frey monofilaments (hair or fibers), which are small pieces of nylon rod, approximately 50 mm in length, and of varying diameters, to test a rodent's sensitivity to punctate mechanical pressure on the plantar surface of a rear paw. Von Frey filaments are able to deliver force in the range of 0.08 to 2940 mN.
slaulederkind
2024-02-19T15:10:13Z
PMID:34808752
von Frey assay condition
experimental_condition_ontology
XCO:0001286
von Frey monofilament stimulus
XCO:0001286
This is any condition in which the main influencing factor is a Von Frey monofilament stimulus, usually encountered in a Von Frey assay, which is used to evaluate mechanical allodynia in laboratory rodents. The von Frey test, which may be manual or electronic, uses von Frey monofilaments (hair or fibers), which are small pieces of nylon rod, approximately 50 mm in length, and of varying diameters, to test a rodent's sensitivity to punctate mechanical pressure on the plantar surface of a rear paw. Von Frey filaments are able to deliver force in the range of 0.08 to 2940 mN.
PMID:28932184
https://en.wikipedia.org/wiki/Nociception_assay
This is any condition in which the main influencing factor is a hot plate stimulus, usually encountered by laboratory rodents in thermal hyperalgesia testing. The hot plate test is a useful screening tool for interventions of analgesia and involves placing the subject on its feet on a temperature-regulatable hot plate inside a cylindrical chamber.
slaulederkind
2024-02-19T15:33:23Z
PMID:34808752
experimental_condition_ontology
XCO:0001287
hot plate stimulus
XCO:0001287
This is any condition in which the main influencing factor is a hot plate stimulus, usually encountered by laboratory rodents in thermal hyperalgesia testing. The hot plate test is a useful screening tool for interventions of analgesia and involves placing the subject on its feet on a temperature-regulatable hot plate inside a cylindrical chamber.
https://en.wikipedia.org/wiki/Hot_plate_test
https://maze.conductscience.com/portfolio/hot-plate/
This is any condition in which the main influencing factor is an acetone drop stimulus, usually encountered in a test used to measure cold allodynia behavior in the experimental subject, typically a rodent. The test involves applying a small drop (50 - 100 ul) of acetone to the mid-plantar area of the hind paw and recording the resulting behavior for one minute. The skin temperature of the subject drops ~3 - 5 degrees during the test.
slaulederkind
2024-02-22T13:16:18Z
PMID:34808752
experimental_condition_ontology
XCO:0001288
acetone drop stimulus
XCO:0001288
This is any condition in which the main influencing factor is an acetone drop stimulus, usually encountered in a test used to measure cold allodynia behavior in the experimental subject, typically a rodent. The test involves applying a small drop (50 - 100 ul) of acetone to the mid-plantar area of the hind paw and recording the resulting behavior for one minute. The skin temperature of the subject drops ~3 - 5 degrees during the test.
PMID:30228362
This is any condition in which the main influencing factor is tenotomy, any process involving transcutaneous or surgical techniques for incision of a tendon to investigate and/or treat a pathological condition. Tenotomy may involve needle puncture, incision, or complete transection of a tendon.
slaulederkind
2024-02-22T14:12:59Z
PMID:35897746
open tenotomy
experimental_condition_ontology
XCO:0001289
tenotomy
XCO:0001289
This is any condition in which the main influencing factor is tenotomy, any process involving transcutaneous or surgical techniques for incision of a tendon to investigate and/or treat a pathological condition. Tenotomy may involve needle puncture, incision, or complete transection of a tendon.
https://my.clevelandclinic.org/health/treatments/24123-tenotomy
This is any condition in which the main influencing factor is Achilles tendon transection, a process involving a surgical technique for complete transection of the calcaneal and plantaris tendon to investigate tendon healing in an experimental animal model.
slaulederkind
2024-02-22T14:31:22Z
Achille's tenotomy
open Achilles tenotomy
experimental_condition_ontology
XCO:0001290
Achilles tendon transection
XCO:0001290
This is any condition in which the main influencing factor is Achilles tendon transection, a process involving a surgical technique for complete transection of the calcaneal and plantaris tendon to investigate tendon healing in an experimental animal model.
PMID:35897746
https://en.wikipedia.org/wiki/Achilles_tendon
This is any condition in which the main influencing factor is particulate matter (particle pollution), a mixture of inhalable, solid particles and liquid droplets found in the air. The size of particulate matter ranges from visible to microscopic.
slaulederkind
2024-02-23T11:04:16Z
PMID:35897746
PM
particle pollution
experimental_condition_ontology
XCO:0001291
particulate matter
XCO:0001291
This is any condition in which the main influencing factor is particulate matter (particle pollution), a mixture of inhalable, solid particles and liquid droplets found in the air. The size of particulate matter ranges from visible to microscopic.
https://www.epa.gov/pm-pollution/particulate-matter-pm-basics#PM
This is any condition in which the main influencing factor is PM2.5, which is particulate matter consisting of fine inhalable particles, with diameters that are generally 2.5 micrometers and smaller.
slaulederkind
2024-02-23T11:11:58Z
PMID:35897746
experimental_condition_ontology
XCO:0001292
PM2.5
XCO:0001292
This is any condition in which the main influencing factor is PM2.5, which is particulate matter consisting of fine inhalable particles, with diameters that are generally 2.5 micrometers and smaller.
slaulederkind
2024-02-23T11:17:32Z
PMID:35897746
2.5 um particulate matter
experimental_condition_ontology
XCO:0001293
PM2.5
XCO:0001293
This is any condition in which the main influencing factor is PM2.5, which is particulate matter consisting of fine inhalable particles, with diameters that are generally 2.5 micrometers and smaller.
https://www.epa.gov/pm-pollution/particulate-matter-pm-basics#PM
This is any condition in which the main influencing factor is PM10, which is particulate matter consisting of inhalable particles, with diameters that are generally 10 micrometers and smaller.
slaulederkind
2024-02-23T11:22:35Z
PMID:35897746
10 um particulate matter
experimental_condition_ontology
XCO:0001294
PM10
XCO:0001294
This is any condition in which the main influencing factor is PM10, which is particulate matter consisting of inhalable particles, with diameters that are generally 10 micrometers and smaller.
https://www.epa.gov/pm-pollution/particulate-matter-pm-basics#PM
This is any condition in which the main influencing factor is gingerol, a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1. Gingerol is a constituent of fresh ginger and other plants. Gingerol may have antifungal and antineoplastic properties.
slaulederkind
2024-02-23T13:21:55Z
CID:442793
MESH:C007845
PMID:35897746
(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
(6)-Gingerol
6-Gingerol
experimental_condition_ontology
XCO:0001295
gingerol
XCO:0001295
This is any condition in which the main influencing factor is gingerol, a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1. Gingerol is a constituent of fresh ginger and other plants. Gingerol may have antifungal and antineoplastic properties.
CHEBI:10136
https://en.wikipedia.org/wiki/File:Gingerol_cytotoxic_activity.jpg
This is any condition in which the main influencing factor is blood transfusion, an intravenous transfer of blood or blood components from one subject to another or from one subject back to the same subject (after treatment or storage of blood/blood product).
slaulederkind
2024-02-23T13:48:00Z
PMID:35897746
transfusion
autologous blood transfusion
homologous blood transfusion
experimental_condition_ontology
XCO:0001296
blood transfusion
XCO:0001296
This is any condition in which the main influencing factor is blood transfusion, an intravenous transfer of blood or blood components from one subject to another or from one subject back to the same subject (after treatment or storage of blood/blood product).
https://en.wikipedia.org/wiki/Blood_transfusion
https://www.merriam-webster.com
This is any condition in which the main influencing factor is autologous blood transfusion, the intravenous reinfusion of blood or blood components to the same individual from whom they were taken.
slaulederkind
2024-02-23T13:55:44Z
PMID:35897746
experimental_condition_ontology
XCO:0001297
autologous blood transfusion
XCO:0001297
This is any condition in which the main influencing factor is autologous blood transfusion, the intravenous reinfusion of blood or blood components to the same individual from whom they were taken.
PMID:8400524
https://www.merriam-webster.com
This is any condition in which the main influencing factor is bleomycin, a complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. Bleomycin inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
slaulederkind
2024-02-23T14:57:46Z
PMID:33881353
bleomycin a2
experimental_condition_ontology
XCO:0001298
bleomycin
XCO:0001298
This is any condition in which the main influencing factor is bleomycin, a complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. Bleomycin inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
CID:5360373
This is any condition in which the main influencing factor is a middle cerebral artery (MCA) occlusion sham procedure, which follows the same surgical process as an MCA occlusion without blocking the middle cerebral artery.
slaulederkind
2024-02-26T14:15:53Z
PMID:2643202
PMID:33935709
MCA occlusion sham procedure
MCA occlusion sham surgery
middle cerebral artery occlusion sham surgery
experimental_condition_ontology
XCO:0001299
middle cerebral artery occlusion sham procedure
XCO:0001299
This is any condition in which the main influencing factor is a middle cerebral artery (MCA) occlusion sham procedure, which follows the same surgical process as an MCA occlusion without blocking the middle cerebral artery.
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is cerebral reperfusion, any situation in which the flow of blood to the cerebral hemispheres is restored after a period of blood vessel occlusion occurring experimentally.
slaulederkind
2024-02-27T14:36:39Z
PMID:33935709
cerebral ischemia-reperfusion
cerebral ischemia/reperfusion
cerebrum ischemia-reperfusion
cerebrum ischemia/reperfusion
cerebrum reperfusion
experimental_condition_ontology
XCO:0001300
cerebral reperfusion
XCO:0001300
This is any condition in which the main influencing factor is cerebral reperfusion, any situation in which the flow of blood to the cerebral hemispheres is restored after a period of blood vessel occlusion occurring experimentally.
ISBN-13:978-1455756438
https://www.merriam-webster.com/
This is any condition in which the main influencing factor is AEGE extract, an herbal mixture extracted from the dried roots and rhizomes or stems of Acanthopanax senticosus Harms (ASH; Eleutherococcus senticosus; Siberian Ginseng) and Gastrodia elata Blume (Tianma; GE).
slaulederkind
2024-02-27T15:16:18Z
AEGE
ASE and GEB
experimental_condition_ontology
XCO:0001301
AEGE extract
XCO:0001301
This is any condition in which the main influencing factor is AEGE extract, an herbal mixture extracted from the dried roots and rhizomes or stems of Acanthopanax senticosus Harms (ASH; Eleutherococcus senticosus; Siberian Ginseng) and Gastrodia elata Blume (Tianma; GE).
PMID:33935709
This is any condition in which the main influencing factor is dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor used for managing diabetes mellitus type 2.
slaulederkind
2024-03-01T10:57:39Z
CHEBI:85078
MESH:C529054
PMID:37383701
(1S)-1,5-anhydro-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol
DAPA
experimental_condition_ontology
XCO:0001302
dapagliflozin
XCO:0001302
This is any condition in which the main influencing factor is dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor used for managing diabetes mellitus type 2.
CID:9887712
This is any condition in which the main influencing factor is sinomenine, a unique plant alkaloid that releases histamine in association with degranulation of tissue mast cells in mammalian tissues. Sinomenine has been used in herbal medicine for the treatment of rheumatism and arthritis. Sinomenine also has anti-angiogenic, anti-inflammatory, and anti-apoptotic effects.
slaulederkind
2024-03-01T11:26:11Z
CHEBI:9163
MESH:C009271
PMID:61710
cocculine
cucoline
cuculine
experimental_condition_ontology
XCO:0001303
sinomenine
XCO:0001303
This is any condition in which the main influencing factor is sinomenine, a unique plant alkaloid that releases histamine in association with degranulation of tissue mast cells in mammalian tissues. Sinomenine has been used in herbal medicine for the treatment of rheumatism and arthritis. Sinomenine also has anti-angiogenic, anti-inflammatory, and anti-apoptotic effects.
CID:5459308
This is any condition in which the main influencing factor is Danlu tongdu, a Chinese patent medicine made up of five traditional Chinese drugs, including Salviae miltiorrhizae, Astragali radix, Eucommiae cortex, Corydalis rhizoma and Cervi cornus colla. Danlu tongdu is used in treatment of lumbar spinal stenosis and lumbosacral disc herniations, but has some adverse side-effects on liver.
slaulederkind
2024-03-04T17:50:54Z
DLTD
experimental_condition_ontology
XCO:0001304
Danlu tongdu
XCO:0001304
This is any condition in which the main influencing factor is Danlu tongdu, a Chinese patent medicine made up of five traditional Chinese drugs, including Salviae miltiorrhizae, Astragali radix, Eucommiae cortex, Corydalis rhizoma and Cervi cornus colla. Danlu tongdu is used in treatment of lumbar spinal stenosis and lumbosacral disc herniations, but has some adverse side-effects on liver.
PMID:36408216
This is any condition in which the main influencing factor is pulmonary artery occlusion, a clinical or experimental surgical procedure which restricts the amount of blood flow to the lung via the pulmonary artery.
slaulederkind
2024-03-05T13:47:25Z
PMID:36631871
PAB
pulmonary artery banding
pulmonary artery ligation
experimental_condition_ontology
XCO:0001305
pulmonary artery occlusion
XCO:0001305
This is any condition in which the main influencing factor is pulmonary artery occlusion, a clinical or experimental surgical procedure which restricts the amount of blood flow to the lung via the pulmonary artery.
PMID:32809673
This is a condition induced by an mechanical procedure involving controlled trauma to skeletal muscle. The controlled muscle trauma may be to model contusion, strain, or laceration.
slaulederkind
2024-03-08T14:04:49Z
experimental mechanical muscle injury
experimental muscle contusion
experimental muscle laceration
experimental muscle strain
experimental_condition_ontology
XCO:0001306
experimental traumatic muscle injury
XCO:0001306
This is a condition induced by an mechanical procedure involving controlled trauma to skeletal muscle. The controlled muscle trauma may be to model contusion, strain, or laceration.
PMID:23328717
PMID:24011855
This is a condition induced by an mechanical procedure involving controlled trauma to skeletal muscle, such as the vastus medialis (part of the quadriceps muscle). Controlled muscle contusion has been used to model myofascial pain syndrome and other skeletal muscle injuries.
slaulederkind
2024-03-08T14:37:50Z
experimental muscle bruise
experimental_condition_ontology
XCO:0001307
experimental muscle contusion
XCO:0001307
This is a condition induced by an mechanical procedure involving controlled trauma to skeletal muscle, such as the vastus medialis (part of the quadriceps muscle). Controlled muscle contusion has been used to model myofascial pain syndrome and other skeletal muscle injuries.
PMID:23328717
PMID:24011855
4.159
JSmith
2014-03-07T11:34:22Z
RO:0002211
experimental_condition_ontology
has_component
has_component
has_component
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experimental_condition_ontology
1.2
jrsmith