format-version: 1.2 date: 11:07:2012 16:25 saved-by: JSmith auto-generated-by: OBO-Edit 2.0 default-namespace: Experimental Conditions. ontology data-version: 1.9 [Term] id: XCO:0000000 name: experimental condition [Term] id: XCO:0000001 name: activity def: "The state of being involved in some action, either physical or mental." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000000 ! experimental condition [Term] id: XCO:0000002 name: resting def: "A state in which the organism is not exhibiting any physical exertion." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000059 ! physical activity [Term] id: XCO:0000003 name: resting on treadmill def: "A state in which the organism is on an non-operating exercise machine in which there is a endless belt that moves when operational so that the organism can walk or run in place." [Encarta:Encarta World English Dictionary] is_a: XCO:0000002 ! resting [Term] id: XCO:0000004 name: walking on treadmill def: "The action of ambulation on an exercise apparatus with an endless moving belt on which the organism can walk in place." [Encarta:Encarta World English Dictionary] is_a: XCO:0000007 ! walking [Term] id: XCO:0000005 name: running on treadmill def: "The act of rapidly moving the feet on an exercise apparatus with an endless belt that allows the user to perform the action of running in place." [Encarta:Encarta World English Dictionary] is_a: XCO:0000008 ! running [Term] id: XCO:0000006 name: swimming def: "The action of moving one's appendages to propel oneself through water." [Encarta:Encarta World English Dictionary] is_a: XCO:0000059 ! physical activity [Term] id: XCO:0000007 name: walking def: "The act of ambulation, moving oneself forward on legs or on an exercise apparatus." [Encarta:Encarta World English Dictionary] is_a: XCO:0000059 ! physical activity [Term] id: XCO:0000008 name: running def: "The action of rapid movement of feet that propels the organism forward or is done on an exercise machine so that the organism performs the activity in place." [Encarta:Encarta World English Dictionary] is_a: XCO:0000059 ! physical activity [Term] id: XCO:0000009 name: controlled atmosphere composition def: "An experimental condition in which the amount of one or more of the gases which make up the air surrounding an organism are controlled as part of the experiment on that organism." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed, MS:ms] is_a: XCO:0000000 ! experimental condition [Term] id: XCO:0000010 name: air oxygen content def: "A condition in which the oxygen level of the air surrounding an organism or breathed by the organism is controlled as part of the experiment." [MS:ms] relationship: OBO_REL:part_of XCO:0000009 ! controlled atmosphere composition [Term] id: XCO:0000011 name: air temperature def: "The degree of heat or cold of the air surrounding an organism." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000111 ! temperature exposure [Term] id: XCO:0000012 name: air carbon dioxide content def: "A condition in which the level of carbon dioxide in the air surrounding the organism or breathed by the organism is controlled as part of the experiment." [MS:ms] relationship: OBO_REL:part_of XCO:0000009 ! controlled atmosphere composition [Term] id: XCO:0000013 name: diet def: "The food and drink consumed by an organism day to day." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] synonym: "Diet" RELATED [NCI:C15222] is_a: XCO:0000000 ! experimental condition [Term] id: XCO:0000014 name: controlled content diet def: "A regimen of solid food in which the amount of one or more elements of the diet are controlled." [MS:ms] is_a: XCO:0000019 ! solid diet [Term] id: XCO:0000015 name: controlled calorie content diet def: "A regimen of solid food in which the number of calories consumed is controlled." [MS:ms] is_a: XCO:0000014 ! controlled content diet [Term] id: XCO:0000016 name: standard rat chow is_a: XCO:0000069 ! standard diet [Term] id: XCO:0000017 name: nephrectomy def: "Surgical removal of kidney." [MS:RGD] is_a: XCO:0000026 ! surgical removal created_by: mshimoyama creation_date: 2011-11-02T02:06:00Z [Term] id: XCO:0000018 name: bilateral nephrectomy def: "Surgical removal of both kidneys." [MS:RGD] is_a: XCO:0000017 ! nephrectomy created_by: mshimoyama creation_date: 2011-11-02T02:07:13Z [Term] id: XCO:0000019 name: solid diet def: "The solid food that is consumed by an organism." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000013 ! diet [Term] id: XCO:0000020 name: drink def: "A liquid consumed by an organism." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000013 ! diet [Term] id: XCO:0000021 name: water is_a: XCO:0000020 ! drink [Term] id: XCO:0000022 name: controlled sodium content diet def: "A regimen of solid food in which the amount of sodium consumed is controlled." [MS:ms] is_a: XCO:0000014 ! controlled content diet [Term] id: XCO:0000023 name: controlled ethanol content water def: "A drink made of water with a specified amount of ethanol added for consumption by an organism in an experiment." [RGD:MS] is_a: XCO:0000070 ! alcoholic drink is_a: XCO:0000163 ! controlled content water [Term] id: XCO:0000024 name: controlled iron content diet def: "A regimen of solid food in which the amount of iron consumed is controlled." [MS:ms] is_a: XCO:0000014 ! controlled content diet [Term] id: XCO:0000025 name: controlled fat content diet def: "A regimen of solid food in which the amount of fat consumed is controlled." [MS:ms] is_a: XCO:0000014 ! controlled content diet [Term] id: XCO:0000026 name: surgical removal def: "Removal of an organ or gland from the boy of an organism prior to an experiment being performed on the organism." [MS:ms] is_a: XCO:0000165 ! surgical manipulation [Term] id: XCO:0000027 name: surgical implantation is_a: XCO:0000165 ! surgical manipulation [Term] id: XCO:0000028 name: caffeinated drink def: "A drink containing caffeine, one of the methylxanthines soluble in water and alcohol and obtainable from coffee, tea, guarana and mate." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000020 ! drink [Term] id: XCO:0000029 name: controlled carbohydrate content diet def: "A regimen of solid food in which the amount of carbohydrates consumed is controlled." [MS:ms] is_a: XCO:0000014 ! controlled content diet [Term] id: XCO:0000030 name: controlled protein content diet def: "A regimen of solid food in which the amount of protein consumed is controlled." [MS:ms] is_a: XCO:0000014 ! controlled content diet [Term] id: XCO:0000031 name: controlled calcium content diet def: "A regimen of solid food in which the amount of calcium consumed is controlled." [MS:ms] is_a: XCO:0000014 ! controlled content diet [Term] id: XCO:0000032 name: controlled potassium content diet def: "A regimen of solid food in which the amount of potassium consumed is controlled." [MS:ms] is_a: XCO:0000014 ! controlled content diet [Term] id: XCO:0000033 name: housing condition is_a: XCO:0000000 ! experimental condition [Term] id: XCO:0000034 name: individual housing is_a: XCO:0000033 ! housing condition [Term] id: XCO:0000035 name: housing in pairs is_a: XCO:0000033 ! housing condition [Term] id: XCO:0000036 name: housing with socially dominant partner is_a: XCO:0000035 ! housing in pairs [Term] id: XCO:0000037 name: housing with socially subordinate partner is_a: XCO:0000035 ! housing in pairs [Term] id: XCO:0000038 name: radiation exposure is_a: XCO:0000000 ! experimental condition [Term] id: XCO:0000039 name: ionizing radiation exposure is_a: XCO:0000038 ! radiation exposure [Term] id: XCO:0000040 name: gamma ray exposure is_a: XCO:0000039 ! ionizing radiation exposure [Term] id: XCO:0000041 name: radon exposure is_a: XCO:0000039 ! ionizing radiation exposure [Term] id: XCO:0000042 name: ultraviolet ray exposure is_a: XCO:0000039 ! ionizing radiation exposure [Term] id: XCO:0000043 name: Xray exposure is_a: XCO:0000039 ! ionizing radiation exposure [Term] id: XCO:0000044 name: non-ionizing radiation exposure is_a: XCO:0000038 ! radiation exposure [Term] id: XCO:0000045 name: electromagnetic radiation exposure is_a: XCO:0000044 ! non-ionizing radiation exposure [Term] id: XCO:0000046 name: infrared radiation exposure is_a: XCO:0000044 ! non-ionizing radiation exposure [Term] id: XCO:0000047 name: sensory stimulus def: "An action or condition designed to cause the registration or perception of a stimulus and the voyage made by incoming nerve impulses from the sense organs to the nerve centers." [MedicineNet:www.medterms.com] is_a: XCO:0000000 ! experimental condition [Term] id: XCO:0000048 name: auditory stimulus def: "Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of hearing." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000047 ! sensory stimulus [Term] id: XCO:0000049 name: visual stimulus def: "Any action or condition designed to cause the registration or perception of a stimulus by the optical sense organs." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000047 ! sensory stimulus [Term] id: XCO:0000050 name: olfactory stimulus def: "Any action or condition designed to cause the registration or perception of a stimulus by organs or receptors involved in the sense of smell." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000047 ! sensory stimulus [Term] id: XCO:0000051 name: taste stimulus def: "Any action or condition designed to cause the registration or perception of a stimulus by the gustatory receptors in the tongue." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000047 ! sensory stimulus [Term] id: XCO:0000052 name: tactile stimulus def: "Any action or condition designed to cause the registration or perception of a stimulus by organs and receptors involved in the sense of touch." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000047 ! sensory stimulus [Term] id: XCO:0000053 name: heat exposure, targeted def: "An activity or condition involving a high temperature targeted to a particular part of an organism's body." [MS:ms] is_a: XCO:0000111 ! temperature exposure [Term] id: XCO:0000054 name: cold exposure, targeted def: "An activity or condition involving a low temperature targeted to a particular part of an organism's body." [MS:ms] is_a: XCO:0000111 ! temperature exposure [Term] id: XCO:0000055 name: electric shock exposure def: "Stimulation of nerves through application of an electric current." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000052 ! tactile stimulus [Term] id: XCO:0000056 name: naive control condition def: "A baseline condition in which none of the experimental manipulations are performed." [MS:ms] synonym: "standard condition" RELATED [] is_a: XCO:0000099 ! control condition [Term] id: XCO:0000057 name: rebreathed air def: "Breathing in again air which has been exhaled." [Merriam Webster:Merriam Webster Online Dictionary] relationship: OBO_REL:part_of XCO:0000009 ! controlled atmosphere composition created_by: mshimoyama creation_date: 2009-12-17T01:47:13Z [Term] id: XCO:0000058 name: room temperature def: "The temperature of the air surrounding an organism which is considered the most common level for the facility. For humans the temperature considered most comfortable for a room is between 18 and 27 degrees celsius." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000011 ! air temperature created_by: mshimoyama creation_date: 2009-12-17T01:49:34Z [Term] id: XCO:0000059 name: physical activity def: "Action in which a part of the body or whole body is involved in movement." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000001 ! activity created_by: mshimoyama creation_date: 2009-12-17T01:50:15Z [Term] id: XCO:0000060 name: mental activity def: "Being in a state of action within the mind often involving manipulation of words or numbers." [Dorland:Dorlands Illustrated Medical Dictionar 31st Ed] is_a: XCO:0000001 ! activity created_by: mshimoyama creation_date: 2009-12-17T01:50:54Z [Term] id: XCO:0000061 name: serial subtraction exercise def: "An activity in which a person starts with a number and deducts a specified number from that and then deducts the same number from the remainder of the first computation, without using a calculator or pencil and paper." [Encarta:Encarta World English Dictionary] is_a: XCO:0000060 ! mental activity created_by: mshimoyama creation_date: 2009-12-17T01:51:15Z [Term] id: XCO:0000062 name: cycling def: "The action of riding on a stationary or moving vehicle with wheels that is propelled by the movement of a person's legs." [MS:ms] is_a: XCO:0000059 ! physical activity created_by: mshimoyama creation_date: 2009-12-17T01:51:51Z [Term] id: XCO:0000063 name: cycling, stationary def: "The act of propelling the wheel or wheels of a fixed exercise machine through the action of one's legs." [MS:ms] is_a: XCO:0000062 ! cycling created_by: mshimoyama creation_date: 2009-12-17T01:52:04Z [Term] id: XCO:0000064 name: cycling, non-stationary def: "The action of propelling a two wheeled vehicle by the movement of a person's legs." [Encarta:Encarta World English Dicitonary] is_a: XCO:0000062 ! cycling created_by: mshimoyama creation_date: 2009-12-17T01:52:17Z [Term] id: XCO:0000065 name: hand dynamometer activity def: "The action of squeezing an apparatus that measures the muscular contraction of the hand, used as a condition of exertion in experiments measuring other physiological functions." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000059 ! physical activity created_by: mshimoyama creation_date: 2009-12-17T01:52:57Z [Term] id: XCO:0000066 name: body position change def: "Change in position or attitude of body as part of the experiment in which measurements are taken before, during and/or after the change." [Dorlands:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000081 ! body position created_by: mshimoyama creation_date: 2009-12-17T01:53:24Z [Term] id: XCO:0000067 name: body position change, seated to standing is_a: XCO:0000066 ! body position change created_by: mshimoyama creation_date: 2009-12-17T01:53:35Z [Term] id: XCO:0000068 name: body position change, supine to standing is_a: XCO:0000066 ! body position change created_by: mshimoyama creation_date: 2009-12-17T01:53:58Z [Term] id: XCO:0000069 name: standard diet is_a: XCO:0000019 ! solid diet created_by: mshimoyama creation_date: 2009-12-17T01:56:44Z [Term] id: XCO:0000070 name: alcoholic drink def: "A drink containing ethanol, a transparent, colorless, volatile,flammable liquid, which is formed by microbial fermentation of carbohydrates." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] synonym: "ethanol" RELATED [] is_a: XCO:0000020 ! drink created_by: mshimoyama creation_date: 2010-01-05T03:10:55Z [Term] id: XCO:0000071 name: beer def: "An alcoholic drink brewed by fermenting malt with sugar and yeast and flavored with hops." [Encarta:Encarta World English Dictionary] is_a: XCO:0000070 ! alcoholic drink created_by: mshimoyama creation_date: 2010-01-05T03:11:11Z [Term] id: XCO:0000072 name: wine def: "Alcoholic drink made by fermenting the juice of grapes." [Encarta:Encarta World English Dictionary] is_a: XCO:0000070 ! alcoholic drink created_by: mshimoyama creation_date: 2010-01-05T03:11:23Z [Term] id: XCO:0000073 name: liquor def: "Alcoholic beverage produced by distillation." [Encarta:Encarta World English Dictionary] is_a: XCO:0000070 ! alcoholic drink created_by: mshimoyama creation_date: 2010-01-05T03:11:33Z [Term] id: XCO:0000074 name: controlled caffeine content water def: "A drink made up of water and a specified amount of caffeine consumed by an organism as part of an experiment." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000028 ! caffeinated drink is_a: XCO:0000163 ! controlled content water created_by: mshimoyama creation_date: 2010-01-05T03:15:30Z [Term] id: XCO:0000075 name: tea is_a: XCO:0000028 ! caffeinated drink created_by: mshimoyama creation_date: 2010-01-05T03:15:42Z [Term] id: XCO:0000076 name: coffee def: "A drink made of the decoction or infusion of the dried, roasted sees of Coffea arabica or Coffea canephora." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000028 ! caffeinated drink created_by: mshimoyama creation_date: 2010-01-05T03:15:55Z [Term] id: XCO:0000077 name: tobacco use def: "The use of any product made for human consumption from Nicotiana tabacum." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000013 ! diet created_by: mshimoyama creation_date: 2010-01-05T03:17:37Z [Term] id: XCO:0000078 name: cigar smoking def: "The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigar, a rolled cylinder of tobacco wrapped in tobacco leaves." [MEDDICT:medical-dictionary.thefreedictionary.com] synonym: "Cigar Smoking NCI Thesaurus" RELATED [NCI:C19702] is_a: XCO:0000077 ! tobacco use created_by: mshimoyama creation_date: 2010-01-05T03:17:52Z [Term] id: XCO:0000079 name: cigarette smoking def: "The action of smoking, inhalation of the gases and hydrocarbon vapors generated by burning a cigarette, a small roll of finely cut tobacco enclosed in a wrapper of thin paper." [MEDDICT:medical-dictionary.thefreedictionary.com] synonym: "Cigarette Smoking_NCI Thesaurus" RELATED [NCI:C18270] is_a: XCO:0000077 ! tobacco use created_by: mshimoyama creation_date: 2010-01-05T03:18:03Z [Term] id: XCO:0000080 name: tobacco chewing def: "Mastication of a form of the prepared leaves of Nicotiana tabacum that is chewed." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000077 ! tobacco use created_by: mshimoyama creation_date: 2010-01-05T03:18:13Z [Term] id: XCO:0000081 name: body position def: "The attitude or posture of the body." [Dorland:Dorlands Illustrated Medical Dicationary 31st Ed] synonym: "posture" RELATED [] is_a: XCO:0000000 ! experimental condition created_by: mshimoyama creation_date: 2010-03-04T09:05:26Z [Term] id: XCO:0000082 name: sitting position def: "A position of rest in which the weight is largely supported by the buttocks, usually with the body vertical." [Encarta:Encarta World English Dicationary] synonym: "seated" RELATED [] is_a: XCO:0000081 ! body position created_by: mshimoyama creation_date: 2010-03-04T09:06:36Z [Term] id: XCO:0000083 name: standing position def: "A position in which an organism is upright balanced on two legs for bipedal organisms or four legs for quadrapedal organisms.." [MS:ms] is_a: XCO:0000081 ! body position created_by: mshimoyama creation_date: 2010-03-04T09:06:49Z [Term] id: XCO:0000084 name: supine position def: "A position in which the organism is lying face up." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000081 ! body position created_by: mshimoyama creation_date: 2010-03-04T09:07:12Z [Term] id: XCO:0000085 name: stationary bicycle dynamometer is_a: XCO:0000063 ! cycling, stationary created_by: mshimoyama creation_date: 2010-03-04T01:56:42Z [Term] id: XCO:0000086 name: exercise training program def: "A fixed series of exercises or body movements repeated at intervals over a specified period of time as part of a program to improve strength, aerobic capacity or other elements of fitness." [MS:ms] is_a: XCO:0000059 ! physical activity created_by: mshimoyama creation_date: 2010-03-04T02:09:06Z [Term] id: XCO:0000087 name: specific pathogen-free conditions is_a: XCO:0000000 ! experimental condition created_by: mshimoyama creation_date: 2010-06-29T03:35:43Z [Term] id: XCO:0000088 name: chemical def: "A substance composed of chemical elements or obtained by chemical processes." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000000 ! experimental condition created_by: mshimoyama creation_date: 2010-11-01T01:00:51Z [Term] id: XCO:0000089 name: neoplasm inducing agent is_a: XCO:0000088 ! chemical created_by: mshimoyama creation_date: 2010-11-01T01:01:08Z [Term] id: XCO:0000090 name: 7,12-dimethyltetraphene (DMBA) def: "A tetraphene having methyl substituents at eht 7- and 12- positions. It is a potent carcinogen and is present in tobacco smoke." [CHEBI:] synonym: "CHEBI:254496" RELATED [CHEBI:CHEBI\:254496] synonym: "D015127" RELATED [] synonym: "DMBA" RELATED [] is_a: XCO:0000093 ! polycyclic arene created_by: mshimoyama creation_date: 2010-11-01T01:01:46Z [Term] id: XCO:0000091 name: steroid is_a: XCO:0000088 ! chemical is_a: XCO:0000089 ! neoplasm inducing agent created_by: mshimoyama creation_date: 2010-11-01T01:03:53Z [Term] id: XCO:0000092 name: 17 beta-estradiol synonym: "CHEBI:16469" RELATED [] synonym: "CO47085" RELATED [] synonym: "E2" RELATED [] is_a: XCO:0000091 ! steroid created_by: mshimoyama creation_date: 2010-11-01T01:04:03Z [Term] id: XCO:0000093 name: polycyclic arene def: "A polycyclic aromatic hydrocarbon." [wikipedia:en.wikipedia.org] synonym: "polycyclic arene" RELATED [Chebi:CHEBI\:33848] is_a: XCO:0000088 ! chemical is_a: XCO:0000089 ! neoplasm inducing agent created_by: mshimoyama creation_date: 2010-11-01T01:07:01Z [Term] id: XCO:0000094 name: ovariectomy def: "The removal of one or both ovaries, the female gonads, from an organism." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] synonym: "oophorectomy" RELATED [] is_a: XCO:0000026 ! surgical removal created_by: mshimoyama creation_date: 2010-11-02T01:28:36Z [Term] id: XCO:0000095 name: bilateral ovariectomy def: "Surgical removal of both ovaries." [MS:RGD] is_a: XCO:0000094 ! ovariectomy created_by: mshimoyama creation_date: 2010-11-02T01:29:19Z [Term] id: XCO:0000096 name: unilateral ovariectomy def: "Surgical removal of a single ovary." [MS:RGD] is_a: XCO:0000094 ! ovariectomy created_by: mshimoyama creation_date: 2010-11-02T01:29:34Z [Term] id: XCO:0000097 name: right ovariectomy def: "Surgical removal of the right ovary." [MS:RGD] is_a: XCO:0000096 ! unilateral ovariectomy created_by: mshimoyama creation_date: 2010-11-02T01:29:48Z [Term] id: XCO:0000098 name: left ovariectomy def: "Surgical removal of the left ovary." [MS:RGD] is_a: XCO:0000096 ! unilateral ovariectomy created_by: mshimoyama creation_date: 2010-11-02T01:30:01Z [Term] id: XCO:0000099 name: control condition def: "A baseline condition in which the experimental observations or measurements may be evaluated." [Dorland:Dorlands Illustrated Medical Dictioanary 31st Ed] is_a: XCO:0000000 ! experimental condition created_by: mshimoyama creation_date: 2010-11-02T02:06:02Z [Term] id: XCO:0000100 name: sham surgical control condition def: "A surgical treatment or procedure that is performed as a control and that is similar to but omits a key therapeutic element of the treatment or procedure under investigation." [Merriam Webster:Merriam webster Online Dictionary] is_a: XCO:0000099 ! control condition created_by: mshimoyama creation_date: 2010-11-02T02:06:46Z [Term] id: XCO:0000101 name: vehicle control condition def: "A treatment or procedure used as a control in which a saline or other solution is injected in the same manner as the experimental solution minus the key element of the experimental solution." [MS:ms] is_a: XCO:0000099 ! control condition created_by: mshimoyama creation_date: 2010-11-02T02:07:02Z [Term] id: XCO:0000102 name: fasting def: "Abstaining from the consumption of food, often for a specified period of time." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000000 ! experimental condition created_by: mshimoyama creation_date: 2010-11-08T09:37:31Z [Term] id: XCO:0000103 name: glucose solution is_a: XCO:0000000 ! experimental condition created_by: mshimoyama creation_date: 2010-11-08T09:40:03Z [Term] id: XCO:0000104 name: glucose solution, 2.8M is_a: XCO:0000103 ! glucose solution created_by: mshimoyama creation_date: 2010-11-08T09:40:19Z [Term] id: XCO:0000105 name: pancreatectomy def: "Surgical removal of part or all of the pancreas, the gland situated transversely behind the stomach, between the spleen and the duodenum." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000026 ! surgical removal created_by: mshimoyama creation_date: 2010-11-10T02:19:58Z [Term] id: XCO:0000106 name: anesthetic def: "Drug or agent used to reduce or eliminate pain or sensation." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000088 ! chemical created_by: mshimoyama creation_date: 2011-01-21T09:44:08Z [Term] id: XCO:0000107 name: pentobarbital def: "Short to intermediate acting barbiturate used as a sedative and hypnotic." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000106 ! anesthetic created_by: mshimoyama creation_date: 2011-01-21T09:45:03Z [Term] id: XCO:0000108 name: pentobarbital, sodium def: "Sodium salt of pentobarbital, a short to intermediate acting barbiturate used as a sedative and hypnotic." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000107 ! pentobarbital created_by: mshimoyama creation_date: 2011-01-21T09:46:40Z [Term] id: XCO:0000109 name: isoflurane def: "Potent inhalational anesthetic." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000106 ! anesthetic created_by: mshimoyama creation_date: 2011-01-21T09:48:47Z [Term] id: XCO:0000110 name: prone position def: "A position in which the organism is lying face down." [Dorland:Dorlands Illustrated Medical Dictionary 31st Ed] is_a: XCO:0000081 ! body position created_by: mshimoyama creation_date: 2011-02-07T01:44:52Z [Term] id: XCO:0000111 name: temperature exposure is_a: XCO:0000000 ! experimental condition created_by: mshimoyama creation_date: 2011-02-08T02:22:15Z [Term] id: XCO:0000112 name: unilateral nephrectomy def: "Surgical removal of a single kidney." [MS:RGD] is_a: XCO:0000017 ! nephrectomy created_by: mshimoyama creation_date: 2011-11-02T02:08:41Z [Term] id: XCO:0000113 name: right nephrectomy def: "Surgical removal of the right kidney." [MS:RGD] is_a: XCO:0000112 ! unilateral nephrectomy created_by: mshimoyama creation_date: 2011-11-02T02:11:31Z [Term] id: XCO:0000114 name: left nephrectomy def: "Surgical removal of the left kidney." [MS:RGD] is_a: XCO:0000112 ! unilateral nephrectomy created_by: mshimoyama creation_date: 2011-11-02T02:12:44Z [Term] id: XCO:0000115 name: perfusate is_a: XCO:0000000 ! experimental condition created_by: mshimoyama creation_date: 2012-01-09T01:29:00Z [Term] id: XCO:0000116 name: Kreb's solution perfusate is_a: XCO:0000115 ! perfusate created_by: mshimoyama creation_date: 2012-01-09T01:29:11Z [Term] id: XCO:0000117 name: saline solution perfusate is_a: XCO:0000115 ! perfusate created_by: mshimoyama creation_date: 2012-01-09T01:29:28Z [Term] id: XCO:0000118 name: perfusate suspended is_a: XCO:0000115 ! perfusate created_by: mshimoyama creation_date: 2012-01-09T01:29:47Z [Term] id: XCO:0000119 name: amino acid def: "Any naturally occurring or synthetic organic compound containing an amino group, a carboxylic acid group and a side chain. An amino acid may be administered as a nutritional supplement or as a drug." [Website:Wikipedia] is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-02-16T12:55:34Z [Term] id: XCO:0000120 name: inhibitor def: "A substance or compound which interferes with a chemical reaction or a molecular or physiological process or activity." [RGD:JRS] is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-02-16T01:09:21Z [Term] id: XCO:0000121 name: NG-Nitroarginine Methyl Ester def: "A basic amino acid, commonly known as L-NAME, used as a non-selective inhibitor of nitric oxide synthase." [MeSH:D019331] synonym: "CHEMBL7890 " RELATED [] synonym: "L-NAME" EXACT [] synonym: "MeSH:D019331" RELATED [] synonym: "PubChem_compound:39836" RELATED [] is_a: XCO:0000119 ! amino acid is_a: XCO:0000120 ! inhibitor created_by: JSmith creation_date: 2012-02-16T01:15:20Z [Term] id: XCO:0000122 name: diuretic def: "A chemical which tends to increase the excretion of urine." [Dictionary:Dorlands_medical_dictionary] is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-02-16T01:51:41Z [Term] id: XCO:0000123 name: sulfonamide def: "A compound containing a sulfonamide functional group. A sulfonamide functional group contains sulfonyl connected to an amine group and has the general structure R-S(=O)2-NH2. Sulfonamide also refers to several classes of drugs which include antimicrobial \"sulfa drugs\", anticonvulsants and the sulfonylureas and thiazide diuretics." [Website:Wikipedia] synonym: "CHEBI:35358" RELATED [] xref: CHEBI:35358 is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-02-16T01:52:39Z [Term] id: XCO:0000124 name: furosemide def: "A diuretic drug which inhibits Nkcc2, one of the Na-K symporters and reduces the reabsorption of sodium chloride. Furosemide is used experimentally for sodium depletion." [Website:Wikipedia] synonym: "Frusemide" RELATED [] synonym: "Lasix" RELATED [] synonym: "PubChem_compound:3440" RELATED [] xref: CHEBI:47426 is_a: XCO:0000122 ! diuretic is_a: XCO:0000123 ! sulfonamide created_by: JSmith creation_date: 2012-02-16T01:53:25Z [Term] id: XCO:0000125 name: hormone def: "A chemical substance produced by an organ, cells of an organ or scattered cells, having a specific regulatory affect on the activity of an organ or tissue." [Dictionary:Dorlands_medical_dictionary] is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-02-16T02:54:55Z [Term] id: XCO:0000126 name: angiotensin def: "A peptide hormone which increases blood pressure by causing blood vessel constriction. Part of the renin-angiotensin system." [Dictionary:Dorlands_medical_dictionary] is_a: XCO:0000125 ! hormone is_a: XCO:0000141 ! vasoconstrictor created_by: JSmith creation_date: 2012-02-16T03:00:38Z [Term] id: XCO:0000127 name: norepinephrine def: "A catecholamine neurotransmitter and stress hormone with multiple physiological roles including affects on heart rate, blood pressure and vascular tone." [Dictionary:Dorlands_medical_dictionary] is_a: XCO:0000125 ! hormone is_a: XCO:0000141 ! vasoconstrictor created_by: JSmith creation_date: 2012-02-16T03:01:05Z [Term] id: XCO:0000128 name: drink with chemical additive is_obsolete: true created_by: JSmith creation_date: 2012-02-16T03:23:23Z [Term] id: XCO:0000129 name: water with NG-Nitroarginine Methyl Ester def: "Drinking water with a specified concentration of NG-Nitroarginine Methyl Ester (L-NAME) added to it. L-NAME is used as a non-selective inhibitor of nitric oxide synthase." [PGA:Renal_protocol] synonym: "water with L-NAME" EXACT [] is_obsolete: true created_by: JSmith creation_date: 2012-02-16T03:23:57Z [Term] id: XCO:0000130 name: ketamine synonym: "PubChem_Compound CID:3821" EXACT [] xref: CHEBI:6121 is_a: XCO:0000106 ! anesthetic created_by: JSmith creation_date: 2012-03-15T07:33:06Z [Term] id: XCO:0000131 name: xylazine synonym: "PubChem_Compound CID:5707" RELATED [] xref: CHEBI:165540 xref: CHEMBL:297362 is_a: XCO:0000106 ! anesthetic created_by: JSmith creation_date: 2012-03-15T07:34:39Z [Term] id: XCO:0000132 name: acepromazine synonym: "PubChem_Compound CID:6077" RELATED [] xref: CHEBI:44932 is_a: XCO:0000106 ! anesthetic created_by: JSmith creation_date: 2012-03-15T07:39:01Z [Term] id: XCO:0000133 name: antigen def: "a chemical compound to which the body can mount a localized or systemic immune reaction, e.g. a T cell or B cell response" [JRS:] is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-03-15T07:42:13Z [Term] id: XCO:0000134 name: methacholine xref: CHEBI:6804 is_a: XCO:0000133 ! antigen is_a: XCO:0000135 ! receptor agonist created_by: JSmith creation_date: 2012-03-15T07:45:00Z [Term] id: XCO:0000135 name: receptor agonist is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-03-15T07:46:38Z [Term] id: XCO:0000136 name: enzyme substrate is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-03-15T07:48:19Z [Term] id: XCO:0000137 name: FAPGG synonym: "3-(2-FurylAcryloyl)-L-PHE-GLY-GLY" EXACT [] synonym: "FurylAcrylolPhenylalanylGlycylGlycine" EXACT [] synonym: "PubChem Compound: CID 6438387" RELATED [] xref: CAS:64566-61-6 is_a: XCO:0000136 ! enzyme substrate created_by: JSmith creation_date: 2012-03-15T07:48:41Z [Term] id: XCO:0000138 name: methylene blue synonym: "PubChem Compound: CID 6099" RELATED [] xref: CHEBI:6872 is_a: XCO:0000120 ! inhibitor is_a: XCO:0000136 ! enzyme substrate created_by: JSmith creation_date: 2012-03-15T07:51:22Z [Term] id: XCO:0000139 name: vasoactive chemical def: "a chemical which can work on the blood vessels and/or cardiovascular system of an organism" [JRS:] is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-03-15T07:53:30Z [Term] id: XCO:0000140 name: vasodilator def: "a chemical which functions to dilate or increase the interior diameter of blood vessels" [JRS:] is_a: XCO:0000139 ! vasoactive chemical created_by: JSmith creation_date: 2012-03-15T07:55:13Z [Term] id: XCO:0000141 name: vasoconstrictor def: "a chemical which acts to constrict or reduce the interior diameter of blood vessels" [JRS:] is_a: XCO:0000139 ! vasoactive chemical created_by: JSmith creation_date: 2012-03-15T07:56:15Z [Term] id: XCO:0000142 name: sodium nitroprusside synonym: "disodium pentacyanonitrosylferrate(2-) dehydrate" EXACT [] synonym: "PubChem_Compound CID:11953891" RELATED [] synonym: "PubChem_Compound CID:11963579" RELATED [] synonym: "sodium nitroferricyanide" EXACT [] xref: CHEBI:29321 is_a: XCO:0000140 ! vasodilator created_by: JSmith creation_date: 2012-03-15T07:58:24Z [Term] id: XCO:0000143 name: acetylcholine synonym: "PubChem_Compound CID:187" RELATED [] xref: CHEBI:15355 is_a: XCO:0000140 ! vasodilator is_a: XCO:0000144 ! neurotransmitter created_by: JSmith creation_date: 2012-03-15T08:00:34Z [Term] id: XCO:0000144 name: neurotransmitter is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-03-15T08:01:41Z [Term] id: XCO:0000145 name: phenylephrine synonym: "PubChem_Compound CID:6041" RELATED [] xref: CHEBI:8093 is_a: XCO:0000135 ! receptor agonist is_a: XCO:0000141 ! vasoconstrictor created_by: JSmith creation_date: 2012-03-15T08:02:39Z [Term] id: XCO:0000146 name: controlled oxygen content Kreb's solution perfusate def: "Kreb's solution perfusate through which oxygen or a high oxygen content gas mixture has been bubbled to increase the oxygen content of the perfusate" [PGA:cardiac_protocol] is_a: XCO:0000116 ! Kreb's solution perfusate created_by: JSmith creation_date: 2012-03-21T02:07:15Z [Term] id: XCO:0000147 name: physiological salt solution perfusate synonym: "PSS" EXACT [] is_a: XCO:0000117 ! saline solution perfusate created_by: JSmith creation_date: 2012-03-21T02:18:12Z [Term] id: XCO:0000148 name: controlled oxygen content physiological salt solution perfusate synonym: "oxygenated PSS" EXACT [] is_a: XCO:0000147 ! physiological salt solution perfusate created_by: JSmith creation_date: 2012-03-21T02:19:03Z [Term] id: XCO:0000149 name: ion/salt is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-03-23T07:25:49Z [Term] id: XCO:0000150 name: potassium salt def: "exposure to a salt of potassium, for example in a solution or as a supplement. Note: not used for potassium salt in animal feed. For that application XCO:0000032, \"controlled potassium content diet\" is used." [JRS:] is_a: XCO:0000149 ! ion/salt created_by: JSmith creation_date: 2012-03-23T07:31:29Z [Term] id: XCO:0000151 name: chemical time series is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-03-23T08:10:45Z [Term] id: XCO:0000152 name: drug dose time series def: "the condition of exposing an organism, organ or tissue to a series of increasing doses of a drug or other chemical from which a single measurement value is obtained" [JRS:] is_a: XCO:0000151 ! chemical time series created_by: JSmith creation_date: 2012-03-23T08:11:18Z [Term] id: XCO:0000153 name: sample resting period synonym: "sample room temperature incubation" RELATED [] is_a: XCO:0000000 ! experimental condition created_by: JSmith creation_date: 2012-03-26T10:46:30Z [Term] id: XCO:0000154 name: ion/salt solution is_a: XCO:0000149 ! ion/salt created_by: JSmith creation_date: 2012-03-26T04:34:54Z [Term] id: XCO:0000155 name: sodium chloride solution synonym: "saline solution" RELATED [] is_a: XCO:0000154 ! ion/salt solution created_by: JSmith creation_date: 2012-03-26T04:36:15Z [Term] id: XCO:0000156 name: 0.9% sodium chloride solution synonym: "0.9% Sodium Chloride Injection" RELATED [] is_a: XCO:0000155 ! sodium chloride solution created_by: JSmith creation_date: 2012-03-26T04:56:10Z [Term] id: XCO:0000157 name: physical restraint def: "the use of manual or mechanical means to limit some or all of an animal's normal movement for the purpose of examination, collection of samples, drug administration, therapy, or experimental manipulation" [NIH:Guide for the Care and Use of Laboratory Animals\, 8th Ed.] is_a: XCO:0000059 ! physical activity created_by: JSmith creation_date: 2012-06-07T12:30:41Z [Term] id: XCO:0000158 name: physical restraint in mechanical restrainer def: "the use of mechanical means to limit some or all of an animal's normal movements" [NIH:Guide for the Care and Use of Laboratory Animals\, 8th Ed.] is_a: XCO:0000157 ! physical restraint created_by: JSmith creation_date: 2012-06-07T12:42:46Z [Term] id: XCO:0000159 name: physical restraint in tube type rodent restrainer def: "the use of a tube type rodent restrainer to limit some or all of an animal's normal movements" [NIH:Guide for the Care and Use of Laboratory Animals\, 8th Ed.] is_a: XCO:0000158 ! physical restraint in mechanical restrainer created_by: JSmith creation_date: 2012-06-07T12:43:33Z [Term] id: XCO:0000160 name: receptor antagonist def: "A substance that binds to a receptor without eliciting a biological response, blocking binding of substances that could elicit such responses." [Dorland:Dorland's Illustrated Medical Dictionary\, 31st Ed] is_a: XCO:0000120 ! inhibitor created_by: JSmith creation_date: 2012-07-03T03:15:44Z [Term] id: XCO:0000161 name: losartan def: "Angiotensin receptor antagonist and vasodilator which consists of a biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position. Losartan also has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position." [CHEBI:6541] xref: CHEBI:6541 is_a: XCO:0000140 ! vasodilator is_a: XCO:0000160 ! receptor antagonist created_by: JSmith creation_date: 2012-07-09T10:53:01Z [Term] id: XCO:0000162 name: pentolinium def: "Nicotinic acetylcholine receptor antagonist, ganglionic blocking agent and vasodilator which consists of a dication whose structure comprises a pentane backbone linking two 1-methylpyrrolidinium groups." [CHEBI:347401] xref: CHEBI:347401 xref: CHEBI:55326 is_a: XCO:0000140 ! vasodilator is_a: XCO:0000160 ! receptor antagonist created_by: JSmith creation_date: 2012-07-09T10:58:54Z [Term] id: XCO:0000163 name: controlled content water def: "Drinking water in which the amount of one or more solutes are controlled." [RGD:JRS] is_a: XCO:0000021 ! water created_by: JSmith creation_date: 2012-07-09T11:14:14Z [Term] id: XCO:0000164 name: controlled sodium content water def: "Drinking water to which a controlled amount of sodium has been added." [RGD:JRS] is_a: XCO:0000163 ! controlled content water created_by: JSmith creation_date: 2012-07-09T11:19:29Z [Term] id: XCO:0000165 name: surgical manipulation def: "Any process involving manual and instrumental techniques for incision or excision of a part of an organism to investigate and/or treat a pathological condition." [Wikipedia:http\://en.wikipedia.org/wiki/Surgery] is_a: XCO:0000000 ! experimental condition created_by: JSmith creation_date: 2012-07-11T01:38:55Z [Term] id: XCO:0000166 name: controlled in situ organ condition def: "Any experimental condition in which the internal or external environment of an organ is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body." [RGD:JRS, RGD:MRD] is_a: XCO:0000000 ! experimental condition created_by: JSmith creation_date: 2012-07-11T02:55:03Z [Term] id: XCO:0000167 name: controlled in situ kidney condition def: "Any experimental condition in which the internal or external environment of one or both kidneys is experimentally manipulated, for example through perfusion, increased or decreased blood flow, etc. without removal from the body." [RGD:JRS] is_a: XCO:0000166 ! controlled in situ organ condition created_by: JSmith creation_date: 2012-07-11T03:01:51Z [Term] id: XCO:0000168 name: controlled in situ renal perfusion pressure def: "Condition in which the perfusion pressure in the renal arteries/veins is experimentally regulated, for example by perfusion or regulated blood flow, without removal from the body." [RGD:JRS] is_a: XCO:0000167 ! controlled in situ kidney condition created_by: JSmith creation_date: 2012-07-11T03:07:44Z [Term] id: XCO:0000169 name: labeled chemical def: "Any chemical to which a tracer has been added such as the addition of a fluorescent tag or inclusion of a radioactive element during synthesis." [RGD:JRS] is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-07-11T03:39:04Z [Term] id: XCO:0000170 name: fluorescently labeled chemical def: "Chemical to which a fluorescent tag has been added as a tracer." [RGD:JRS] is_a: XCO:0000169 ! labeled chemical created_by: JSmith creation_date: 2012-07-11T03:51:55Z [Term] id: XCO:0000171 name: radioactively labeled chemical def: "Chemical into which a radioactive element has been incorporated as a tracer." [RGD:JRS] is_a: XCO:0000169 ! labeled chemical created_by: JSmith creation_date: 2012-07-11T03:53:33Z [Term] id: XCO:0000172 name: carbohydrate def: "Any of a group of organic compounds that includes sugars, starches, celluloses, and gums and serves as a major energy source in the diet of animals." [Dictionary:The American Heritage Medical Dictionary] xref: CHEBI:16646 is_a: XCO:0000088 ! chemical created_by: JSmith creation_date: 2012-07-11T04:09:48Z [Term] id: XCO:0000173 name: polysaccharide def: "A macromolecule consisting of large numbers of monosaccharide residues linked glycosidically." [CHEBI:18154 ] xref: CHEBI:18154 is_a: XCO:0000172 ! carbohydrate created_by: JSmith creation_date: 2012-07-11T04:13:15Z [Term] id: XCO:0000174 name: inulin def: "A fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration." [Mosby:Mosby's Medical Dictionary\, 8th Ed] xref: CHEBI:15443 is_a: XCO:0000173 ! polysaccharide created_by: JSmith creation_date: 2012-07-11T04:15:22Z [Term] id: XCO:0000175 name: tritiated inulin def: "Inulin, a fructose-based starch derived from rhizomes of plants from the Compositae family and used as a diagnostic aid in tests of kidney function, specifically glomerular filtration, into which the mass 3 radioactive isotope of hydrogen has been incorporated as a tracer." [Dictionary:Saunders Comprehensive Veterinary Dictionary\, 3rd Ed, Mosby:Mosby's Medical Dictionary\, 8th Ed] synonym: "3H-inulin" EXACT [] is_a: XCO:0000171 ! radioactively labeled chemical is_a: XCO:0000174 ! inulin created_by: JSmith creation_date: 2012-07-11T04:18:17Z [Typedef] id: OBO_REL:part_of name: part_of is_transitive: true