{"id":"http://purl.obolibrary.org/obo/NCIT_C16889","prefLabel":"Oncogene N-RAS","definition":["Human Oncogene N-RAS is a mutated variant of NRAS Gene (RAS Family), which encodes p21 N-Ras Protein, a monomeric GTPase involved in transmembrane signal transduction that alternates between inactive GDP-bound and active GTP-bound forms. RAS is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS stabilizes MYC protein and enhances MYC accumulation by the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Implicated in a variety of human tumors, specific amino acid mutations activate c-RAS and transform cells. Oncogene NRAS disrupts normal cell function."],"prefixIRI":"NCIT:C16889","label":["Oncogene N-RAS"],"subClassOf":["http://purl.obolibrary.org/obo/NCIT_C17061"],"parents":[{"id":"http://purl.obolibrary.org/obo/NCIT_C17061","prefLabel":"RAS Family Oncogene","definition":["A family of oncogenes that are highly homologous with the retrovirus-associated DNA sequences (ras) originally isolated from Harvey and Kirsten murine sarcoma viruses. Mutated or overexpressed forms of the human ras genes are associated with constitutive ras GTPase activity, increased cellular proliferation, and cell transformation."],"prefixIRI":"NCIT:C17061","label":["RAS Family Oncogene"],"subClassOf":["http://purl.obolibrary.org/obo/NCIT_C18340"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/NCIT_C17061","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061","ontology":"https://data.bioontology.org/ontologies/BERO","children":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061/children","parents":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061/parents","descendants":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061/descendants","ancestors":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061/ancestors","instances":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061/instances","tree":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061/tree","notes":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061/notes","mappings":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061/mappings","ui":"http://bioportal.bioontology.org/ontologies/BERO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C17061","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[],"isInActiveCollection":[],"properties":{"http://purl.obolibrary.org/obo/NCIT_NHC0":["C16889"],"https://data.bioontology.org/metadata/def/prefLabel":["Oncogene N-RAS"],"https://data.bioontology.org/metadata/prefixIRI":["NCIT:C16889"],"http://purl.obolibrary.org/obo/NCIT_P100":["164790"],"http://www.geneontology.org/formats/oboInOwl#inSubset":["http://purl.obolibrary.org/obo/NCIT_C116977","http://purl.obolibrary.org/obo/NCIT_C142800","http://purl.obolibrary.org/obo/NCIT_C142799"],"http://purl.obolibrary.org/obo/NCIT_P107":["Oncogene N-RAS"],"http://purl.obolibrary.org/obo/NCIT_P108":["Oncogene N-RAS"],"http://www.w3.org/2000/01/rdf-schema#label":["Oncogene N-RAS"],"http://purl.obolibrary.org/obo/IAO_0000115":["Human Oncogene N-RAS is a mutated variant of NRAS Gene (RAS Family), which encodes p21 N-Ras Protein, a monomeric GTPase involved in transmembrane signal transduction that alternates between inactive GDP-bound and active GTP-bound forms. RAS is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS stabilizes MYC protein and enhances MYC accumulation by the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Implicated in a variety of human tumors, specific amino acid mutations activate c-RAS and transform cells. Oncogene NRAS disrupts normal cell function."],"http://purl.obolibrary.org/obo/NCIT_P322":["CTRP"],"http://purl.obolibrary.org/obo/NCIT_P366":["Oncogene_N-RAS"],"http://purl.obolibrary.org/obo/NCIT_P102":["X02751"],"http://purl.obolibrary.org/obo/NCIT_A13":["http://purl.obolibrary.org/obo/NCIT_C25786"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/NCIT_C17061"],"http://purl.obolibrary.org/obo/NCIT_P106":["Gene or Genome"],"http://purl.obolibrary.org/obo/NCIT_P207":["C0027260"]},"@id":"http://purl.obolibrary.org/obo/NCIT_C16889","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889","ontology":"https://data.bioontology.org/ontologies/BERO","children":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889/children","parents":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889/parents","descendants":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889/descendants","ancestors":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889/ancestors","instances":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889/instances","tree":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889/tree","notes":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889/notes","mappings":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889/mappings","ui":"http://bioportal.bioontology.org/ontologies/BERO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C16889","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}