{"id":"http://purl.obolibrary.org/obo/NCIT_C29474","prefLabel":"Transferrin Receptor-Targeted Liposomal p53 cDNA","definition":["A cationic liposomal, tumor-targeting p53 (TP53) gene delivery system with potential anti-tumor activity. Transferrin receptor-targeted liposomal p53 cDNA contains plasmid DNA encoding the tumor suppressor protein p53 packaged in membrane-like liposome capsules that are complexed with anti-transferrin receptor single-chain antibody (TfRscFv). Upon systemic administration, the anti-TfRscFv selectively binds to tumor cells expressing transferrin receptors. The p53 plasmid is delivered into the nucleus and as a result, p53 protein is produced in tumor cells that have altered p53 function. This results in the restoration of normal cell growth control mechanisms as well as normal response mechanisms to DNA damage."],"prefixIRI":"NCIT:C29474","label":["Transferrin Receptor-Targeted Liposomal p53 cDNA"],"subClassOf":["http://purl.obolibrary.org/obo/NCIT_C61199","http://purl.obolibrary.org/obo/NCIT_C1962","http://purl.obolibrary.org/obo/NCIT_C129821"],"parents":[{"id":"http://purl.obolibrary.org/obo/NCIT_C61199","prefLabel":"Gene Transfer or Gene Delivery Agent","definition":["Genetic engineered recombinant products, including viral or non-viral based system that can be used to transfer genetic materials of interest into cells for either research or clinical purpose."],"prefixIRI":"NCIT:C61199","label":["Gene Transfer or Gene Delivery Agent"],"subClassOf":["http://purl.obolibrary.org/obo/NCIT_C307"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/NCIT_C61199","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199","ontology":"https://data.bioontology.org/ontologies/BERO","children":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199/children","parents":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199/parents","descendants":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199/descendants","ancestors":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199/ancestors","instances":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199/instances","tree":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199/tree","notes":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199/notes","mappings":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199/mappings","ui":"http://bioportal.bioontology.org/ontologies/BERO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C61199","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}},{"id":"http://purl.obolibrary.org/obo/NCIT_C1962","prefLabel":"Gene Therapy Agent","definition":["DNA constructs or co-administered agents used in gene therapy. Gene therapy constructs are used in delivery of genetic material into cells in order to permanently correct an inherited disease or an acquired disease such as cancer."],"prefixIRI":"NCIT:C1962","label":["Gene Therapy Agent"],"subClassOf":["http://purl.obolibrary.org/obo/NCIT_C307"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/NCIT_C1962","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962","ontology":"https://data.bioontology.org/ontologies/BERO","children":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962/children","parents":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962/parents","descendants":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962/descendants","ancestors":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962/ancestors","instances":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962/instances","tree":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962/tree","notes":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962/notes","mappings":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962/mappings","ui":"http://bioportal.bioontology.org/ontologies/BERO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1962","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}},{"id":"http://purl.obolibrary.org/obo/NCIT_C129821","prefLabel":"Antineoplastic Biological Agent","definition":["Any agent that has a biological nature, such as agents containing living organisms, derived from living organisms, or comprised of ex vivo synthesized analogs of substances derived from living organisms, and that exerts antineoplastic activity."],"prefixIRI":"NCIT:C129821","label":["Antineoplastic Biological Agent"],"subClassOf":["http://purl.obolibrary.org/obo/NCIT_C274","http://purl.obolibrary.org/obo/NCIT_C307"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/NCIT_C129821","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821","ontology":"https://data.bioontology.org/ontologies/BERO","children":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821/children","parents":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821/parents","descendants":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821/descendants","ancestors":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821/ancestors","instances":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821/instances","tree":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821/tree","notes":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821/notes","mappings":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821/mappings","ui":"http://bioportal.bioontology.org/ontologies/BERO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C129821","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[],"isInActiveCollection":[],"properties":{"http://purl.obolibrary.org/obo/NCIT_P208":["CL319865"],"http://purl.obolibrary.org/obo/NCIT_P330":["551892"],"http://purl.obolibrary.org/obo/NCIT_NHC0":["C29474"],"https://data.bioontology.org/metadata/def/prefLabel":["Transferrin Receptor-Targeted Liposomal p53 cDNA"],"https://data.bioontology.org/metadata/prefixIRI":["NCIT:C29474"],"http://www.geneontology.org/formats/oboInOwl#inSubset":["http://purl.obolibrary.org/obo/NCIT_C177537","http://purl.obolibrary.org/obo/NCIT_C176424","http://purl.obolibrary.org/obo/NCIT_C128784","http://purl.obolibrary.org/obo/NCIT_C157711","http://purl.obolibrary.org/obo/NCIT_C157712"],"http://purl.obolibrary.org/obo/NCIT_P108":["Transferrin Receptor-Targeted Liposomal p53 cDNA"],"http://www.w3.org/2000/01/rdf-schema#label":["Transferrin Receptor-Targeted Liposomal p53 cDNA"],"http://purl.obolibrary.org/obo/IAO_0000115":["A cationic liposomal, tumor-targeting p53 (TP53) gene delivery system with potential anti-tumor activity. Transferrin receptor-targeted liposomal p53 cDNA contains plasmid DNA encoding the tumor suppressor protein p53 packaged in membrane-like liposome capsules that are complexed with anti-transferrin receptor single-chain antibody (TfRscFv). Upon systemic administration, the anti-TfRscFv selectively binds to tumor cells expressing transferrin receptors. The p53 plasmid is delivered into the nucleus and as a result, p53 protein is produced in tumor cells that have altered p53 function. This results in the restoration of normal cell growth control mechanisms as well as normal response mechanisms to DNA damage."],"http://purl.obolibrary.org/obo/NCIT_P375":["Transferrin Receptor-Targeted Liposomal p53 cDNA"],"http://purl.obolibrary.org/obo/NCIT_P175":["709399"],"http://purl.obolibrary.org/obo/NCIT_P399":["551892"],"http://purl.obolibrary.org/obo/NCIT_P366":["Synerlip_p53"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://purl.obolibrary.org/obo/NCIT_A32":["http://purl.obolibrary.org/obo/NCIT_C1909"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/NCIT_C61199","http://purl.obolibrary.org/obo/NCIT_C1962","http://purl.obolibrary.org/obo/NCIT_C129821"],"http://purl.obolibrary.org/obo/NCIT_P329":["551892"],"http://purl.obolibrary.org/obo/NCIT_P106":["Pharmacologic Substance"]},"@id":"http://purl.obolibrary.org/obo/NCIT_C29474","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474","ontology":"https://data.bioontology.org/ontologies/BERO","children":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474/children","parents":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474/parents","descendants":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474/descendants","ancestors":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474/ancestors","instances":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474/instances","tree":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474/tree","notes":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474/notes","mappings":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474/mappings","ui":"http://bioportal.bioontology.org/ontologies/BERO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C29474","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007f5978e25580 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-867ff0f5194c/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}