{"id":"http://purl.obolibrary.org/obo/NCIT_C99761","prefLabel":"Antiangiogenic Drug Combination TL-118","definition":["A proprietary, oral suspension containing a combination of agents comprised of a nonsteroidal anti-inflammatory agent, an alkylating agent, a histamine H2 antagonist and a sulfonamide with potential anti-angiogenic and antineoplastic activities. Antiangiogenic drug combination TL-118 is administrated as a specific dosing regimen and may result in a synergistic effect and reduce angiogenesis and inhibit tumor cell proliferation."],"prefixIRI":"NCIT:C99761","label":["Antiangiogenic Drug Combination TL-118"],"subClassOf":["http://purl.obolibrary.org/obo/NCIT_C1742"],"parents":[{"id":"http://purl.obolibrary.org/obo/NCIT_C1742","prefLabel":"Angiogenesis Inhibitor","definition":["An agent or endogenous substance that inhibits the formation of capillaries from existing blood vessels. In cancer therapy, angiogenesis inhibitors preferentially target the new blood vessels that tumors require for oxygen and nutrition, thereby inhibiting the growth and spread of these tumors."],"prefixIRI":"NCIT:C1742","label":["Angiogenesis Inhibitor"],"subClassOf":["http://purl.obolibrary.org/obo/NCIT_C274"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/NCIT_C1742","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742","ontology":"https://data.bioontology.org/ontologies/BERO","children":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742/children","parents":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742/parents","descendants":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742/descendants","ancestors":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742/ancestors","instances":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742/instances","tree":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742/tree","notes":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742/notes","mappings":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742/mappings","ui":"http://bioportal.bioontology.org/ontologies/BERO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C1742","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://purl.obolibrary.org/obo/NCIT_P330":["723650"],"http://purl.obolibrary.org/obo/NCIT_NHC0":["C99761"],"https://data.bioontology.org/metadata/def/prefLabel":["Antiangiogenic Drug Combination TL-118"],"https://data.bioontology.org/metadata/prefixIRI":["NCIT:C99761"],"http://www.geneontology.org/formats/oboInOwl#inSubset":["http://purl.obolibrary.org/obo/NCIT_C177537","http://purl.obolibrary.org/obo/NCIT_C128784","http://purl.obolibrary.org/obo/NCIT_C157711","http://purl.obolibrary.org/obo/NCIT_C157712"],"http://purl.obolibrary.org/obo/NCIT_P108":["Antiangiogenic Drug Combination TL-118"],"http://www.w3.org/2000/01/rdf-schema#label":["Antiangiogenic Drug Combination TL-118"],"http://purl.obolibrary.org/obo/IAO_0000115":["A proprietary, oral suspension containing a combination of agents comprised of a nonsteroidal anti-inflammatory agent, an alkylating agent, a histamine H2 antagonist and a sulfonamide with potential anti-angiogenic and antineoplastic activities. Antiangiogenic drug combination TL-118 is administrated as a specific dosing regimen and may result in a synergistic effect and reduce angiogenesis and inhibit tumor cell proliferation."],"http://purl.obolibrary.org/obo/NCIT_P375":["Antiangiogenic Drug Combination TL-118"],"http://purl.obolibrary.org/obo/NCIT_P399":["723650"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://purl.obolibrary.org/obo/NCIT_A32":["http://purl.obolibrary.org/obo/NCIT_C1909"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/NCIT_C1742"],"http://purl.obolibrary.org/obo/NCIT_P329":["723650"],"http://purl.obolibrary.org/obo/NCIT_P106":["Pharmacologic Substance"],"http://purl.obolibrary.org/obo/NCIT_P207":["C3274907"]},"@id":"http://purl.obolibrary.org/obo/NCIT_C99761","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761","ontology":"https://data.bioontology.org/ontologies/BERO","children":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761/children","parents":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761/parents","descendants":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761/descendants","ancestors":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761/ancestors","instances":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761/instances","tree":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761/tree","notes":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761/notes","mappings":"https://data.bioontology.org/ontologies/BERO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761/mappings","ui":"http://bioportal.bioontology.org/ontologies/BERO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FNCIT_C99761","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}