8 21 30 https://w3id.org/biolink/vocab/PredicateQualifierEnum predicate_qualifier_enum 'predicate_qualifier_enum' EquivalentTo 'hypothesized' or 'possibly' or 'predicted' or 'supported by clinical evidence' or 'supported by real-world evidence' or 'validated' https://w3id.org/biolink/vocab/VariableStateQualifierEnum variable_state_qualifier_enum 'variable_state_qualifier_enum' EquivalentTo 'present' https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum molecular_control_mechanism_qualifier_enum 'molecular_control_mechanism_qualifier_enum' EquivalentTo 'agonism' or 'antagonism' or 'antibody inhibitor' or 'binding' or 'inactivation' or 'inhibition' or 'inverse agonism' or 'molecular channel blockage' or 'molecular channel opening' or 'negative allosteric modulation' or 'neutralization' or 'positive allosteric modulation' or 'potentiation' https://w3id.org/biolink/vocab/RelativeTimingQualifierEnum relative_timing_qualifier_enum 'relative_timing_qualifier_enum' EquivalentTo 'future' https://w3id.org/biolink/vocab/DirectionQualifierEnum direction_qualifier_enum 'direction_qualifier_enum' EquivalentTo 'decreases' or 'downregulate' or 'increases' or 'upregulate' 'direction_qualifier_enum' EquivalentTo https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreased or https://w3id.org/biolink/vocab/DirectionQualifierEnum#downregulated or https://w3id.org/biolink/vocab/DirectionQualifierEnum#increased or https://w3id.org/biolink/vocab/DirectionQualifierEnum#upregulated https://w3id.org/biolink/vocab/NamedThingAssociatedWithLikelihoodOfNamedThingAssociation named thing associated with likelihood of named thing association 'named thing associated with likelihood of named thing association' SubClassOf https://w3id.org/biolink/vocab/subject_location_qualifier max 1 'ontology class' 'named thing associated with likelihood of named thing association' SubClassOf https://w3id.org/biolink/vocab/subject_variable_state_qualifier max 1 'variable_state_qualifier_enum' 'named thing associated with likelihood of named thing association' SubClassOf https://w3id.org/biolink/vocab/object_variable_state_qualifier max 1 'variable_state_qualifier_enum' 'named thing associated with likelihood of named thing association' SubClassOf https://w3id.org/biolink/vocab/object_location_qualifier max 1 'ontology class' 'named thing associated with likelihood of named thing association' SubClassOf https://w3id.org/biolink/vocab/subject_context_qualifier max 1 'ontology class' 'named thing associated with likelihood of named thing association' SubClassOf https://w3id.org/biolink/vocab/object_context_qualifier max 1 'ontology class' https://w3id.org/biolink/vocab/ChemicalGeneInteractionAssociation chemical gene interaction association 'chemical gene interaction association' SubClassOf https://w3id.org/biolink/vocab/interaction_mechanism_qualifier max 1 'molecular_control_mechanism_qualifier_enum' 'chemical gene interaction association' SubClassOf 'chemical to entity association mixin' https://w3id.org/biolink/vocab/ChemicalAffectsGeneAssociation chemical affects gene association 'chemical affects gene association' SubClassOf https://w3id.org/biolink/vocab/effect_mechanism_qualifier max 1 'molecular_control_mechanism_qualifier_enum' 'chemical affects gene association' SubClassOf https://w3id.org/biolink/vocab/causal_mechanism_qualifier max 1 https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse+agonism inverse agonism https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#activation activation https://w3id.org/biolink/vocab/AnatomicalContextQualifierEnum anatomical_context_qualifier_enum 'anatomical_context_qualifier_enum' EquivalentTo https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling-mediated+control signaling-mediated control https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody+inhibition antibody inhibition https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive+allosteric+modulation positive allosteric modulation https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#binding binding https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative+allosteric+modulation negative allosteric modulation https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreased decreased https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional+regulation transcriptional regulation https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular+channel+opening molecular channel opening https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#agonism agonism https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antagonism antagonism https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#potentiation potentiation https://w3id.org/biolink/vocab/DirectionQualifierEnum#upregulated upregulated https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inhibition inhibition https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular+channel+blockage molecular channel blockage https://w3id.org/biolink/vocab/DirectionQualifierEnum#downregulated downregulated https://w3id.org/biolink/vocab/DirectionQualifierEnum#increased increased https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum causal_mechanism_qualifier_enum 'causal_mechanism_qualifier_enum' EquivalentTo 'activation' or 'agonism' or 'antagonism' or 'antibody inhibition' or 'binding' or 'inducer' or 'inhibition' or 'inverse agonism' or 'molecular channel blockage' or 'molecular channel opening' or 'negative allosteric modulation' or 'positive allosteric modulation' or 'potentiation' or 'signaling-mediated control' or 'transcriptional regulation' https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inducer inducer https://w3id.org/biolink/vocab/PredicateQualifierEnum predicate_qualifier_enum 'predicate_qualifier_enum' EquivalentTo 'hypothesized' or 'possibly' or 'predicted' or 'supported by clinical evidence' or 'supported by real-world evidence' or 'validated' https://w3id.org/biolink/vocab/PredicateQualifierEnum#hypothesized hypothesized https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#potentiation potentiation https://w3id.org/biolink/vocab/PredicateQualifierEnum#supported+by+real-world+evidence supported by real-world evidence https://w3id.org/biolink/vocab/DirectionQualifierEnum#upregulate upregulate https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#positive+allosteric+modulation positive allosteric modulation https://w3id.org/biolink/vocab/VariableStateQualifierEnum variable_state_qualifier_enum 'variable_state_qualifier_enum' EquivalentTo 'present' https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum molecular_control_mechanism_qualifier_enum 'molecular_control_mechanism_qualifier_enum' EquivalentTo 'agonism' or 'antagonism' or 'antibody inhibitor' or 'binding' or 'inactivation' or 'inhibition' or 'inverse agonism' or 'molecular channel blockage' or 'molecular channel opening' or 'negative allosteric modulation' or 'neutralization' or 'positive allosteric modulation' or 'potentiation' https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#inhibition inhibition https://w3id.org/biolink/vocab/ChemicalSubstance chemical substance https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#antagonism antagonism https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#agonism agonism https://w3id.org/biolink/vocab/VariableStateQualifierEnum#present present https://w3id.org/biolink/vocab/PredicateQualifierEnum#validated validated https://w3id.org/biolink/vocab/RelativeTimingQualifierEnum relative_timing_qualifier_enum 'relative_timing_qualifier_enum' EquivalentTo 'future' https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#inactivation inactivation https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#antibody+inhibitor antibody inhibitor https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#molecular+channel+blockage molecular channel blockage https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#binding binding https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#negative+allosteric+modulation negative allosteric modulation https://w3id.org/biolink/vocab/DirectionQualifierEnum#decreases decreases https://w3id.org/biolink/vocab/PredicateQualifierEnum#supported+by+clinical+evidence supported by clinical evidence https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#neutralization neutralization https://w3id.org/biolink/vocab/DirectionQualifierEnum#increases increases https://w3id.org/biolink/vocab/PredicateQualifierEnum#possibly possibly https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#molecular+channel+opening molecular channel opening https://w3id.org/biolink/vocab/MolecularControlMechanismQualifierEnum#inverse+agonism inverse agonism https://w3id.org/biolink/vocab/PredicateQualifierEnum#predicted predicted https://w3id.org/biolink/vocab/DirectionQualifierEnum#downregulate downregulate https://w3id.org/biolink/vocab/RelativeTimingQualifierEnum#future future