<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
12
</numberChangedClasses>
<numberNewClasses>
52
</numberNewClasses>
<numberDeletedClasses>
52
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/SequenceEnum</classIRI>
<classLabel>sequence_enum</classLabel>
<deletedAxiom>&apos;sequence_enum&apos; EquivalentTo &apos;AA&apos; or &apos;NA&apos;</deletedAxiom>
<newAxiom>&apos;sequence_enum&apos; EquivalentTo https://w3id.org/biolink/vocab/SequenceEnum#aa or https://w3id.org/biolink/vocab/SequenceEnum#na</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum</classIRI>
<classLabel>FDA_IDA_adverse_event_enum</classLabel>
<deletedAxiom>&apos;FDA_IDA_adverse_event_enum&apos; EquivalentTo &apos;Life-threatening adverse event&apos; or &apos;Serious adverse event&apos; or &apos;Suspected adverse reaction&apos; or &apos;Unexpected adverse event&apos;</deletedAxiom>
<newAxiom>&apos;FDA_IDA_adverse_event_enum&apos; EquivalentTo https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#life_threatening_adverse_event or https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#serious_adverse_event or https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#suspected_adverse_reaction or https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#unexpected_adverse_event</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/DrugAvailabilityEnum</classIRI>
<classLabel>drug_availability_enum</classLabel>
<deletedAxiom>&apos;drug_availability_enum&apos; EquivalentTo &apos;over the counter&apos; or &apos;prescription&apos;</deletedAxiom>
<newAxiom>&apos;drug_availability_enum&apos; EquivalentTo https://w3id.org/biolink/vocab/DrugAvailabilityEnum#over_the_counter or &apos;prescription&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum</classIRI>
<classLabel>FDA_approval_status_enum</classLabel>
<deletedAxiom>&apos;FDA_approval_status_enum&apos; EquivalentTo &apos;Discovery &amp; Development Phase&apos; or &apos;FDA Accelerated Approval&apos; or &apos;FDA Breakthrough Therapy&apos; or &apos;FDA Clinical Research Phase&apos; or &apos;FDA Clinical Research Phase 1&apos; or &apos;FDA Clinical Research Phase 2&apos; or &apos;FDA Clinical Research Phase 3&apos; or &apos;FDA Clinical Research Phase 4&apos; or &apos;FDA Fast Track&apos; or &apos;FDA Post-Market Safety Monitoring&apos; or &apos;FDA Priority Review&apos; or &apos;FDA Review Phase 4&apos; or &apos;Post-Approval Withdrawal&apos; or &apos;Preclinical Research Phase&apos; or &apos;Regular FDA Approval&apos;</deletedAxiom>
<newAxiom>&apos;FDA_approval_status_enum&apos; EquivalentTo https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#discovery_and_development_phase or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_accelerated_approval or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_breakthrough_therapy or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_1 or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_2 or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_3 or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_4 or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_fast_track or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_post_market_safety_review or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_priority_review or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_review_phase_4 or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#post_approval_withdrawal or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#preclinical_research_phase or https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#regular_fda_approval</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum</classIRI>
<classLabel>druggable_gene_category_enum</classLabel>
<deletedAxiom>&apos;druggable_gene_category_enum&apos; EquivalentTo &apos;Tbio&apos; or &apos;Tchem&apos; or &apos;Tclin&apos; or &apos;Tdark&apos;</deletedAxiom>
<newAxiom>&apos;druggable_gene_category_enum&apos; EquivalentTo https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tbio or https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tchem or https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tclin or https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tdark</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum</classIRI>
<classLabel>chemical_or_gene_or_gene_product_form_or_variant_enum</classLabel>
<deletedAxiom>&apos;chemical_or_gene_or_gene_product_form_or_variant_enum&apos; EquivalentTo &apos;SNP form&apos; or &apos;analog form&apos; or &apos;genetic variant form&apos; or &apos;mutant form&apos; or &apos;polymorphic form&apos;</deletedAxiom>
<newAxiom>&apos;chemical_or_gene_or_gene_product_form_or_variant_enum&apos; EquivalentTo https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#analog_form or https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form or https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#mutant_form or https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic_form or https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#snp_form</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum</classIRI>
<classLabel>gene_or_gene_product_or_chemical_entity_aspect_enum</classLabel>
<deletedAxiom>&apos;gene_or_gene_product_or_chemical_entity_aspect_enum&apos; EquivalentTo &apos;ADP-ribosylation&apos; or &apos;N-linked glycosylation&apos; or &apos;O-linked glycosylation&apos; or &apos;abundance&apos; or &apos;acetylation&apos; or &apos;activity&apos; or &apos;activity or abundance&apos; or &apos;acylation&apos; or &apos;alkylation&apos; or &apos;amination&apos; or &apos;carbamoylation&apos; or &apos;carboxylation&apos; or &apos;cleavage&apos; or &apos;degradation&apos; or &apos;ethylation&apos; or &apos;expression&apos; or &apos;farnesylation&apos; or &apos;folding&apos; or &apos;geranoylation&apos; or &apos;glucuronidation&apos; or &apos;glutathionylation&apos; or &apos;glycation&apos; or &apos;glycosylation&apos; or &apos;hydrolysis&apos; or &apos;hydroxylation&apos; or &apos;lipidation&apos; or &apos;localization&apos; or &apos;metabolic processing&apos; or &apos;methylation&apos; or &apos;molecular modification&apos; or &apos;mutation rate&apos; or &apos;myristoylation&apos; or &apos;nitrosation&apos; or &apos;nucleotidylation&apos; or &apos;oxidation&apos; or &apos;palmitoylation&apos; or &apos;phosphorylation&apos; or &apos;prenylation&apos; or &apos;reduction&apos; or &apos;ribosylation&apos; or &apos;secretion&apos; or &apos;stability&apos; or &apos;sulfation&apos; or &apos;sumoylation&apos; or &apos;synthesis&apos; or &apos;transport&apos; or &apos;ubiquitination&apos; or &apos;uptake&apos;</deletedAxiom>
<newAxiom>&apos;gene_or_gene_product_or_chemical_entity_aspect_enum&apos; EquivalentTo &apos;ADP-ribosylation&apos; or &apos;abundance&apos; or &apos;acetylation&apos; or &apos;activity&apos; or https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance or &apos;acylation&apos; or &apos;alkylation&apos; or &apos;amination&apos; or &apos;carbamoylation&apos; or &apos;carboxylation&apos; or &apos;cleavage&apos; or &apos;degradation&apos; or &apos;ethylation&apos; or &apos;expression&apos; or &apos;farnesylation&apos; or &apos;folding&apos; or &apos;geranoylation&apos; or &apos;glucuronidation&apos; or &apos;glutathionylation&apos; or &apos;glycation&apos; or &apos;glycosylation&apos; or &apos;hydrolysis&apos; or &apos;hydroxylation&apos; or &apos;lipidation&apos; or &apos;localization&apos; or https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#metabolic_processing or &apos;methylation&apos; or https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification or https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#mutation_rate or &apos;myristoylation&apos; or https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#n_linked_glycosylation or &apos;nitrosation&apos; or &apos;nucleotidylation&apos; or https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#o_linked_glycosylation or &apos;oxidation&apos; or &apos;palmitoylation&apos; or &apos;phosphorylation&apos; or &apos;prenylation&apos; or &apos;reduction&apos; or &apos;ribosylation&apos; or &apos;secretion&apos; or &apos;stability&apos; or &apos;sulfation&apos; or &apos;sumoylation&apos; or &apos;synthesis&apos; or &apos;transport&apos; or &apos;ubiquitination&apos; or &apos;uptake&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum</classIRI>
<classLabel>causal_mechanism_qualifier_enum</classLabel>
<deletedAxiom>&apos;causal_mechanism_qualifier_enum&apos; EquivalentTo &apos;activation&apos; or &apos;agonism&apos; or &apos;antagonism&apos; or &apos;antibody inhibition&apos; or &apos;binding&apos; or &apos;inducer&apos; or &apos;inhibition&apos; or &apos;inverse agonism&apos; or &apos;molecular channel blockage&apos; or &apos;molecular channel opening&apos; or &apos;negative allosteric modulation&apos; or &apos;positive allosteric modulation&apos; or &apos;potentiation&apos; or &apos;releasing activity&apos; or &apos;signaling-mediated control&apos; or &apos;stabilization&apos; or &apos;stimulation&apos; or &apos;transcriptional regulation&apos;</deletedAxiom>
<newAxiom>&apos;causal_mechanism_qualifier_enum&apos; EquivalentTo &apos;activation&apos; or &apos;agonism&apos; or &apos;antagonism&apos; or https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_inhibition or &apos;binding&apos; or &apos;inducer&apos; or &apos;inhibition&apos; or https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse_agonism or https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_blockage or https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_opening or https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_allosteric_modulation or https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_allosteric_modulation or &apos;potentiation&apos; or https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#releasing_activity or https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling_mediated_control or &apos;stabilization&apos; or &apos;stimulation&apos; or https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional_regulation</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum</classIRI>
<classLabel>gene_or_gene_product_or_chemical_part_qualifier_enum</classLabel>
<deletedAxiom>&apos;gene_or_gene_product_or_chemical_part_qualifier_enum&apos; EquivalentTo &apos;3&apos; UTR&apos; or &apos;5&apos; UTR&apos; or &apos;enhancer&apos; or &apos;exon&apos; or &apos;intron&apos; or &apos;polyA tail&apos; or &apos;promoter&apos;</deletedAxiom>
<newAxiom>&apos;gene_or_gene_product_or_chemical_part_qualifier_enum&apos; EquivalentTo https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#3_prime_utr or https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#5_prime_utr or &apos;enhancer&apos; or &apos;exon&apos; or &apos;intron&apos; or https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#polya_tail or &apos;promoter&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalAffectsGeneAssociation</classIRI>
<classLabel>chemical affects gene association</classLabel>
<deletedAxiom>&apos;chemical affects gene association&apos; SubClassOf &apos;object aspect qualifier&apos; max 1 &apos;gene_or_gene_product_or_chemical_entity_aspect_enum&apos;</deletedAxiom>
<deletedAxiom>&apos;chemical affects gene association&apos; SubClassOf &apos;subject aspect qualifier&apos; max 1 &apos;gene_or_gene_product_or_chemical_entity_aspect_enum&apos;</deletedAxiom>
<newAxiom>&apos;chemical affects gene association&apos; SubClassOf &apos;subject aspect qualifier&apos; max 1 &apos;gene_or_gene_product_or_chemical_part_qualifier_enum&apos;</newAxiom>
<newAxiom>&apos;chemical affects gene association&apos; SubClassOf &apos;object aspect qualifier&apos; max 1 &apos;gene_or_gene_product_or_chemical_part_qualifier_enum&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/LogicalInterpretationEnum</classIRI>
<classLabel>logical_interpretation_enum</classLabel>
<deletedAxiom>&apos;logical_interpretation_enum&apos; EquivalentTo &apos;AllSome&apos; or &apos;SomeSome&apos; or &apos;InverseAllSome&apos;</deletedAxiom>
<newAxiom>&apos;logical_interpretation_enum&apos; EquivalentTo &apos;AllSome&apos; or &apos;SomeSome&apos; or https://w3id.org/biolink/vocab/LogicalInterpretationEnum#inverse_all_some</newAxiom>
</changedClass>
<changedClass>
<classIRI>https://w3id.org/biolink/vocab/DrugDeliveryEnum</classIRI>
<classLabel>drug_delivery_enum</classLabel>
<deletedAxiom>&apos;drug_delivery_enum&apos; EquivalentTo &apos;absorbtion through the skin&apos; or &apos;inhalation&apos; or &apos;intravenous injection&apos; or &apos;oral&apos;</deletedAxiom>
<newAxiom>&apos;drug_delivery_enum&apos; EquivalentTo https://w3id.org/biolink/vocab/DrugDeliveryEnum#absorbtion_through_the_skin or &apos;inhalation&apos; or https://w3id.org/biolink/vocab/DrugDeliveryEnum#intravenous_injection or &apos;oral&apos;</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#unexpected_adverse_event</classIRI>
<classLabel>unexpected_adverse_event</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative_allosteric_modulation</classIRI>
<classLabel>negative_allosteric_modulation</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive_allosteric_modulation</classIRI>
<classLabel>positive_allosteric_modulation</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#life_threatening_adverse_event</classIRI>
<classLabel>life_threatening_adverse_event</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#post_approval_withdrawal</classIRI>
<classLabel>post_approval_withdrawal</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity_or_abundance</classIRI>
<classLabel>activity_or_abundance</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase</classIRI>
<classLabel>fda_clinical_research_phase</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse_agonism</classIRI>
<classLabel>inverse_agonism</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#analog_form</classIRI>
<classLabel>analog_form</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_fast_track</classIRI>
<classLabel>fda_fast_track</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/DrugDeliveryEnum#intravenous_injection</classIRI>
<classLabel>intravenous_injection</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling_mediated_control</classIRI>
<classLabel>signaling_mediated_control</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#regular_fda_approval</classIRI>
<classLabel>regular_fda_approval</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_accelerated_approval</classIRI>
<classLabel>fda_accelerated_approval</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#o_linked_glycosylation</classIRI>
<classLabel>o_linked_glycosylation</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#mutation_rate</classIRI>
<classLabel>mutation_rate</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/SequenceEnum#aa</classIRI>
<classLabel>aa</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/LogicalInterpretationEnum#inverse_all_some</classIRI>
<classLabel>inverse_all_some</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_3</classIRI>
<classLabel>fda_clinical_research_phase_3</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_4</classIRI>
<classLabel>fda_clinical_research_phase_4</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#polya_tail</classIRI>
<classLabel>polya_tail</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_1</classIRI>
<classLabel>fda_clinical_research_phase_1</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_clinical_research_phase_2</classIRI>
<classLabel>fda_clinical_research_phase_2</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#serious_adverse_event</classIRI>
<classLabel>serious_adverse_event</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#discovery_and_development_phase</classIRI>
<classLabel>discovery_and_development_phase</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#snp_form</classIRI>
<classLabel>snp_form</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#releasing_activity</classIRI>
<classLabel>releasing_activity</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic_form</classIRI>
<classLabel>polymorphic_form</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tchem</classIRI>
<classLabel>tchem</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/DrugDeliveryEnum#absorbtion_through_the_skin</classIRI>
<classLabel>absorbtion_through_the_skin</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tdark</classIRI>
<classLabel>tdark</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tbio</classIRI>
<classLabel>tbio</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#3_prime_utr</classIRI>
<classLabel>3_prime_utr</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#tclin</classIRI>
<classLabel>tclin</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_priority_review</classIRI>
<classLabel>fda_priority_review</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic_variant_form</classIRI>
<classLabel>genetic_variant_form</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_breakthrough_therapy</classIRI>
<classLabel>fda_breakthrough_therapy</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_post_market_safety_review</classIRI>
<classLabel>fda_post_market_safety_review</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_blockage</classIRI>
<classLabel>molecular_channel_blockage</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#n_linked_glycosylation</classIRI>
<classLabel>n_linked_glycosylation</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular_channel_opening</classIRI>
<classLabel>molecular_channel_opening</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#fda_review_phase_4</classIRI>
<classLabel>fda_review_phase_4</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/SequenceEnum#na</classIRI>
<classLabel>na</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody_inhibition</classIRI>
<classLabel>antibody_inhibition</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#5_prime_utr</classIRI>
<classLabel>5_prime_utr</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular_modification</classIRI>
<classLabel>molecular_modification</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#mutant_form</classIRI>
<classLabel>mutant_form</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#preclinical_research_phase</classIRI>
<classLabel>preclinical_research_phase</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#metabolic_processing</classIRI>
<classLabel>metabolic_processing</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#suspected_adverse_reaction</classIRI>
<classLabel>suspected_adverse_reaction</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional_regulation</classIRI>
<classLabel>transcriptional_regulation</classLabel>
</newClass>
<newClass>
<classIRI>https://w3id.org/biolink/vocab/DrugAvailabilityEnum#over_the_counter</classIRI>
<classLabel>over_the_counter</classLabel>
</newClass>
</newClasses>
<deletedClasses>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#mutation+rate</classIRI>
<classLabel>mutation rate</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#inverse+agonism</classIRI>
<classLabel>inverse agonism</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Accelerated+Approval</classIRI>
<classLabel>FDA Accelerated Approval</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Breakthrough+Therapy</classIRI>
<classLabel>FDA Breakthrough Therapy</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#5'+UTR</classIRI>
<classLabel>5' UTR</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#releasing+activity</classIRI>
<classLabel>releasing activity</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Clinical+Research+Phase+4</classIRI>
<classLabel>FDA Clinical Research Phase 4</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Clinical+Research+Phase+3</classIRI>
<classLabel>FDA Clinical Research Phase 3</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Clinical+Research+Phase+2</classIRI>
<classLabel>FDA Clinical Research Phase 2</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Clinical+Research+Phase+1</classIRI>
<classLabel>FDA Clinical Research Phase 1</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#activity+or+abundance</classIRI>
<classLabel>activity or abundance</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Post-Market+Safety+Monitoring</classIRI>
<classLabel>FDA Post-Market Safety Monitoring</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#metabolic+processing</classIRI>
<classLabel>metabolic processing</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#Life-threatening+adverse+event</classIRI>
<classLabel>Life-threatening adverse event</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#molecular+modification</classIRI>
<classLabel>molecular modification</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#signaling-mediated+control</classIRI>
<classLabel>signaling-mediated control</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#antibody+inhibition</classIRI>
<classLabel>antibody inhibition</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/DrugAvailabilityEnum#over+the+counter</classIRI>
<classLabel>over the counter</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Fast+Track</classIRI>
<classLabel>FDA Fast Track</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#analog+form</classIRI>
<classLabel>analog form</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#N-linked+glycosylation</classIRI>
<classLabel>N-linked glycosylation</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Priority+Review</classIRI>
<classLabel>FDA Priority Review</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#3'+UTR</classIRI>
<classLabel>3' UTR</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/SequenceEnum#AA</classIRI>
<classLabel>AA</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#positive+allosteric+modulation</classIRI>
<classLabel>positive allosteric modulation</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#SNP+form</classIRI>
<classLabel>SNP form</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#Tbio</classIRI>
<classLabel>Tbio</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#negative+allosteric+modulation</classIRI>
<classLabel>negative allosteric modulation</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#genetic+variant+form</classIRI>
<classLabel>genetic variant form</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#mutant+form</classIRI>
<classLabel>mutant form</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#Serious+adverse+event</classIRI>
<classLabel>Serious adverse event</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/DrugDeliveryEnum#absorbtion+through+the+skin</classIRI>
<classLabel>absorbtion through the skin</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#transcriptional+regulation</classIRI>
<classLabel>transcriptional regulation</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Clinical+Research+Phase</classIRI>
<classLabel>FDA Clinical Research Phase</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular+channel+opening</classIRI>
<classLabel>molecular channel opening</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#Unexpected+adverse+event</classIRI>
<classLabel>Unexpected adverse event</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#Tclin</classIRI>
<classLabel>Tclin</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#Post-Approval+Withdrawal</classIRI>
<classLabel>Post-Approval Withdrawal</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalEntityAspectEnum#O-linked+glycosylation</classIRI>
<classLabel>O-linked glycosylation</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#Preclinical+Research+Phase</classIRI>
<classLabel>Preclinical Research Phase</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/CausalMechanismQualifierEnum#molecular+channel+blockage</classIRI>
<classLabel>molecular channel blockage</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/ChemicalOrGeneOrGeneProductFormOrVariantEnum#polymorphic+form</classIRI>
<classLabel>polymorphic form</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#Regular+FDA+Approval</classIRI>
<classLabel>Regular FDA Approval</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#FDA+Review+Phase+4</classIRI>
<classLabel>FDA Review Phase 4</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#Tdark</classIRI>
<classLabel>Tdark</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/GeneOrGeneProductOrChemicalPartQualifierEnum#polyA+tail</classIRI>
<classLabel>polyA tail</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/DruggableGeneCategoryEnum#Tchem</classIRI>
<classLabel>Tchem</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/DrugDeliveryEnum#intravenous+injection</classIRI>
<classLabel>intravenous injection</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/SequenceEnum#NA</classIRI>
<classLabel>NA</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/LogicalInterpretationEnum#InverseAllSome</classIRI>
<classLabel>InverseAllSome</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAApprovalStatusEnum#Discovery+&+Development+Phase</classIRI>
<classLabel>Discovery & Development Phase</classLabel>
</deletedClass>
<deletedClass>
<classIRI>https://w3id.org/biolink/vocab/FDAIDAAdverseEventEnum#Suspected+adverse+reaction</classIRI>
<classLabel>Suspected adverse reaction</classLabel>
</deletedClass>
</deletedClasses>
</diffReport>