{"id":"urn:agi-pathway:uuid-6cdb8148-853d-413b-877c-6977a21b5735","prefLabel":"Hematopoietic Cell Lineage: B-cell (mouse)","obsolete":false,"definition":[],"synonym":["PathwayType: signaling","Source: Biomarkers","CellType: B-cell","Organ_System: lymphatic system","Notes: Headnote: Hematopoietic stem cells (HSCs) are progenitor cells that differentiate into all other blood cell types via the process of hematopoiesis.    Signaling description: Classically, HSCs are thought to differentiate into two distinct leneages, i.e. lymphoid and myelo-erythroid cells. Hematopoetic lineage cell can be identified by the expression of specific cell surface lineage markers. In mice common lymphoid progenitor cells are the earliest lymphoid progenitor cells, and give rise to T-lineage cells, B-lineage cells, natural killer (NK) cells.     Highlighted proteins: Proteins with decreased expression or activity are highlighted in blue. Proteins with increased expression or activity are highlighted in red.","Pathway_Author: A. Nesterova ORCID:0000-0002-9448-8101","Organ_System: hematological system","Tissue: bone marrow","Description: Hematopoietic stem cells (HSCs) are progenitor cells which differentiate to all blood cell types in hematopoiesis.","NodeType: Pathway","CellType: stem cell","Link: https://mammal-profservices.pathwaystudio.com/app/sd?urn=urn:agi-pathway:uuid-6cdb8148-853d-413b-877c-6977a21b5735"],"isInActiveScheme":[null],"isInActiveCollection":[],"parents":[{"id":"urn:agi-folder:cell_lineage","prefLabel":"Cell lineage","obsolete":false,"definition":[],"synonym":["NodeType: Folder"],"inScheme":[],"cui":[],"semanticType":[],"created":null,"modified":null,"notation":"cell:lineage","label":["Cell lineage"],"prefixIRI":null,"subClassOf":["urn:agi-folder:pathways"],"xref":"PS:NodeType","altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"@id":"urn:agi-folder:cell_lineage","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Acell_lineage","ontology":"https://data.bioontology.org/ontologies/BPT","children":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Acell_lineage/children","parents":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Acell_lineage/parents","descendants":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Acell_lineage/descendants","ancestors":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Acell_lineage/ancestors","instances":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Acell_lineage/instances","tree":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Acell_lineage/tree","notes":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Acell_lineage/notes","mappings":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Acell_lineage/mappings","ui":"http://bioportal.bioontology.org/ontologies/BPT?p=classes&conceptid=urn%3Aagi-folder%3Acell_lineage","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":"en"}},{"id":"urn:agi-folder:hematological_system","prefLabel":"Hematological system","obsolete":false,"definition":[],"synonym":["NodeType: Folder"],"inScheme":[],"cui":[],"semanticType":[],"created":null,"modified":null,"notation":"hematological:system","label":["Hematological system"],"prefixIRI":null,"subClassOf":["urn:agi-folder:organ_systems"],"xref":"PS:NodeType","altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"@id":"urn:agi-folder:hematological_system","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ahematological_system","ontology":"https://data.bioontology.org/ontologies/BPT","children":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ahematological_system/children","parents":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ahematological_system/parents","descendants":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ahematological_system/descendants","ancestors":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ahematological_system/ancestors","instances":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ahematological_system/instances","tree":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ahematological_system/tree","notes":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ahematological_system/notes","mappings":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ahematological_system/mappings","ui":"http://bioportal.bioontology.org/ontologies/BPT?p=classes&conceptid=urn%3Aagi-folder%3Ahematological_system","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":"en"}},{"id":"urn:agi-folder:h","prefLabel":"H","obsolete":false,"definition":[],"synonym":["NodeType: Folder"],"inScheme":[],"cui":[],"semanticType":[],"created":null,"modified":null,"notation":"h","label":["H"],"prefixIRI":null,"subClassOf":["urn:agi-folder:all_pathways_and_groups"],"xref":"PS:NodeType","altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"@id":"urn:agi-folder:h","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ah","ontology":"https://data.bioontology.org/ontologies/BPT","children":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ah/children","parents":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ah/parents","descendants":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ah/descendants","ancestors":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ah/ancestors","instances":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ah/instances","tree":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ah/tree","notes":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ah/notes","mappings":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Ah/mappings","ui":"http://bioportal.bioontology.org/ontologies/BPT?p=classes&conceptid=urn%3Aagi-folder%3Ah","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":"en"}},{"id":"urn:agi-folder:lymphatic_system","prefLabel":"Lymphatic system","obsolete":false,"definition":[],"synonym":["NodeType: Folder"],"inScheme":[],"cui":[],"semanticType":[],"created":null,"modified":null,"notation":"lymphatic:system","label":["Lymphatic system"],"prefixIRI":null,"subClassOf":["urn:agi-folder:organ_systems"],"xref":"PS:NodeType","altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"@id":"urn:agi-folder:lymphatic_system","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Alymphatic_system","ontology":"https://data.bioontology.org/ontologies/BPT","children":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Alymphatic_system/children","parents":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Alymphatic_system/parents","descendants":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Alymphatic_system/descendants","ancestors":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Alymphatic_system/ancestors","instances":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Alymphatic_system/instances","tree":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Alymphatic_system/tree","notes":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Alymphatic_system/notes","mappings":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-folder%3Alymphatic_system/mappings","ui":"http://bioportal.bioontology.org/ontologies/BPT?p=classes&conceptid=urn%3Aagi-folder%3Alymphatic_system","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":"en"}}],"inScheme":[],"memberOf":[],"cui":[],"semanticType":[],"created":null,"modified":null,"notation":"uuid-6cdb8148-853d-413b-877c-6977a21b5735","label":["Hematopoietic Cell Lineage: B-cell (mouse)"],"prefixIRI":null,"subClassOf":["urn:agi-folder:cell_lineage","urn:agi-folder:hematological_system","urn:agi-folder:h","urn:agi-folder:lymphatic_system"],"xref":"PS:PathwayType","altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"properties":{"http://www.geneontology.org/formats/oboInOwl#hasDbXref":["PS:PathwayType","PS:Description","PS:Tissue","PS:Pathway_Author","PS:Link","PS:CellType","PS:Organ_System","PS:NodeType","PS:Notes","PS:Source"],"http://www.w3.org/2004/02/skos/core#notation":["uuid-6cdb8148-853d-413b-877c-6977a21b5735"],"http://www.geneontology.org/formats/oboInOwl#id":["urn:agi-pathway:uuid-6cdb8148-853d-413b-877c-6977a21b5735"],"http://www.w3.org/2000/01/rdf-schema#label":["Hematopoietic Cell Lineage: B-cell (mouse)"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["urn:agi-folder:cell_lineage","urn:agi-folder:hematological_system","urn:agi-folder:h","urn:agi-folder:lymphatic_system"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"https://data.bioontology.org/metadata/def/prefLabel":["Hematopoietic Cell Lineage: B-cell (mouse)"],"http://www.geneontology.org/formats/oboInOwl#hasExactSynonym":["PathwayType: signaling","Source: Biomarkers","CellType: B-cell","Organ_System: lymphatic system","Notes: Headnote: Hematopoietic stem cells (HSCs) are progenitor cells that differentiate into all other blood cell types via the process of hematopoiesis.    Signaling description: Classically, HSCs are thought to differentiate into two distinct leneages, i.e. lymphoid and myelo-erythroid cells. Hematopoetic lineage cell can be identified by the expression of specific cell surface lineage markers. In mice common lymphoid progenitor cells are the earliest lymphoid progenitor cells, and give rise to T-lineage cells, B-lineage cells, natural killer (NK) cells.     Highlighted proteins: Proteins with decreased expression or activity are highlighted in blue. Proteins with increased expression or activity are highlighted in red.","Pathway_Author: A. Nesterova ORCID:0000-0002-9448-8101","Organ_System: hematological system","Tissue: bone marrow","Description: Hematopoietic stem cells (HSCs) are progenitor cells which differentiate to all blood cell types in hematopoiesis.","NodeType: Pathway","CellType: stem cell","Link: https://mammal-profservices.pathwaystudio.com/app/sd?urn=urn:agi-pathway:uuid-6cdb8148-853d-413b-877c-6977a21b5735"],"https://data.bioontology.org/metadata/treeView":["urn:agi-folder:cell_lineage","urn:agi-folder:hematological_system","urn:agi-folder:h","urn:agi-folder:lymphatic_system"]},"@id":"urn:agi-pathway:uuid-6cdb8148-853d-413b-877c-6977a21b5735","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735","ontology":"https://data.bioontology.org/ontologies/BPT","children":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735/children","parents":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735/parents","descendants":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735/descendants","ancestors":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735/ancestors","instances":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735/instances","tree":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735/tree","notes":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735/notes","mappings":"https://data.bioontology.org/ontologies/BPT/classes/urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735/mappings","ui":"http://bioportal.bioontology.org/ontologies/BPT?p=classes&conceptid=urn%3Aagi-pathway%3Auuid-6cdb8148-853d-413b-877c-6977a21b5735","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema#parents","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":"en"}}