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GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative."],"prefixIRI":"CL:0000557","xref":"ZFA:0009251","label":["granulocyte monocyte progenitor cell"],"subClassOf":["http://purl.obolibrary.org/obo/CL_1001610","http://purl.obolibrary.org/obo/CL_0002032","http://purl.obolibrary.org/obo/CL_0001012","http://purl.obolibrary.org/obo/CL_0000763"],"parents":[{"id":"http://purl.obolibrary.org/obo/CL_1001610","prefLabel":"bone marrow hematopoietic cell","definition":["Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes."],"synonym":["bone marrow poietic cells","bone marrow hematopoietic cells"],"prefixIRI":"CL:1001610","xref":"CALOHA:TS-2109","label":["bone marrow hematopoietic cell"],"subClassOf":["http://purl.obolibrary.org/obo/CL_0002092","http://purl.obolibrary.org/obo/CL_0000988"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/CL_1001610","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610","ontology":"https://data.bioontology.org/ontologies/CL","children":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610/children","parents":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610/parents","descendants":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610/descendants","ancestors":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610/ancestors","instances":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610/instances","tree":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610/tree","notes":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610/notes","mappings":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610/mappings","ui":"http://bioportal.bioontology.org/ontologies/CL?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_1001610","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}},{"id":"http://purl.obolibrary.org/obo/CL_0002032","definition":["A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.","This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060)."],"prefixIRI":"CL:0002032","prefLabel":"hematopoietic oligopotent progenitor cell","label":["hematopoietic oligopotent progenitor 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(DC_CL:1110000)(PMID:19243617)."],"subClassOf":["http://purl.obolibrary.org/obo/CL_0001060","http://purl.obolibrary.org/obo/CL_0011026"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/CL_0001012","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012","ontology":"https://data.bioontology.org/ontologies/CL","children":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012/children","parents":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012/parents","descendants":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012/descendants","ancestors":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012/ancestors","instances":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012/instances","tree":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012/tree","notes":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012/notes","mappings":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012/mappings","ui":"http://bioportal.bioontology.org/ontologies/CL?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0001012","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}},{"id":"http://purl.obolibrary.org/obo/CL_0000763","definition":["A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage."],"prefixIRI":"CL:0000763","xref":"CALOHA:TS-0647","prefLabel":"myeloid cell","label":["myeloid 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monocyte progenitor cell"],"https://data.bioontology.org/metadata/prefixIRI":["CL:0000557"],"http://www.geneontology.org/formats/oboInOwl#hasExactSynonym":["colony forming unit granulocyte macrophage","granulocyte-macrophage progenitor","granulocyte/monocyte progenitor","granulocyte/monocyte precursor"],"http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym":["CFU-GM","GMP"],"http://www.w3.org/2000/01/rdf-schema#seeAlso":["https://cellxgene.cziscience.com/cellguide/CL_0000557"],"http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym":["CFU-C , Colony forming unit in culture"],"http://www.geneontology.org/formats/oboInOwl#inSubset":["http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas","http://purl.obolibrary.org/obo/cl#human_subset","http://purl.obolibrary.org/obo/cl#mouse_subset","http://purl.obolibrary.org/obo/cl#cellxgene_subset"],"http://purl.obolibrary.org/obo/RO_0002215":["http://purl.obolibrary.org/obo/GO_0030851","http://purl.obolibrary.org/obo/GO_0030225"],"http://www.w3.org/2000/01/rdf-schema#label":["granulocyte monocyte progenitor cell"],"http://purl.obolibrary.org/obo/IAO_0000115":["A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1."],"http://purl.obolibrary.org/obo/BFO_0000051":["http://purl.obolibrary.org/obo/PR_000001944","http://purl.obolibrary.org/obo/PR_000005307"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/CL_1001610","http://purl.obolibrary.org/obo/CL_0002032","http://purl.obolibrary.org/obo/CL_0001012","http://purl.obolibrary.org/obo/CL_0000763"],"http://purl.org/dc/terms/description":["Granulocyte monocyte progenitor cells (GMP cells), originating from hematopoietic stem cells in the bone marrow, are a critical intermediate in myeloid cell development. Positioned at a key differentiation juncture, these cells exhibit bidirectional potential, giving rise to both granulocyte and monocyte lineages.\nTheir primary role is to generate mature granulocytes and monocytes, essential components of the body's innate immunity and inflammatory responses. Granulocytes, such as neutrophils, eosinophils, and basophils, contribute to the first line of defense against infections by migrating to the infection site and phagocytosing pathogens. Monocytes can differentiate into macrophages or dendritic cells, playing diverse roles in immune responses.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)"],"http://www.w3.org/2000/01/rdf-schema#comment":["Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative."],"http://purl.obolibrary.org/obo/RO_0002104":["http://purl.obolibrary.org/obo/PR_000001865"],"http://www.geneontology.org/formats/oboInOwl#hasDbXref":["ZFA:0009251"]},"@id":"http://purl.obolibrary.org/obo/CL_0000557","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557","ontology":"https://data.bioontology.org/ontologies/CL","children":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557/children","parents":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557/parents","descendants":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557/descendants","ancestors":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557/ancestors","instances":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557/instances","tree":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557/tree","notes":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557/notes","mappings":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557/mappings","ui":"http://bioportal.bioontology.org/ontologies/CL?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCL_0000557","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}