{"id":"http://purl.obolibrary.org/obo/GO_0007186","prefLabel":"G protein-coupled receptor signaling pathway","synonym":["GPCR signalling pathway","G protein coupled receptor protein signalling pathway","G-protein-coupled receptor protein signalling pathway","G-protein coupled receptor protein signal transduction","G protein coupled receptor protein signaling pathway","GPCR signaling pathway","G-protein coupled receptor signalling pathway","G-protein coupled receptor protein signaling pathway","dimeric G-protein coupled receptor signalling pathway","G-protein coupled receptor signaling pathway via GPCR dimer","dimeric G-protein coupled receptor signaling pathway"],"definition":["The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane."],"notation":"GO:0007186","xref":"Reactome:R-HSA-373076","label":["G protein-coupled receptor signaling pathway"],"subClassOf":["http://purl.obolibrary.org/obo/GO_0007165"],"parents":[{"id":"http://purl.obolibrary.org/obo/GO_0007165","prefLabel":"signal transduction","definition":["The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.","Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not."],"synonym":["signaling pathway","signalling pathway","signalling cascade","signaling cascade"],"notation":"GO:0007165","xref":"Wikipedia:Signal_transduction","label":["signal transduction"],"subClassOf":["http://purl.obolibrary.org/obo/GO_0050794","http://purl.obolibrary.org/obo/GO_0009987"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"obsolete":false,"prefixIRI":null,"semanticType":[],"cui":[],"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/GO_0007165","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165","ontology":"https://data.bioontology.org/ontologies/CL","children":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165/children","parents":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165/parents","descendants":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165/descendants","ancestors":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165/ancestors","instances":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165/instances","tree":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165/tree","notes":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165/notes","mappings":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165/mappings","ui":"http://bioportal.bioontology.org/ontologies/CL?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007165","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"obsolete":false,"prefixIRI":null,"semanticType":[],"cui":[],"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"https://data.bioontology.org/metadata/def/prefLabel":["G protein-coupled receptor signaling pathway"],"http://www.geneontology.org/formats/oboInOwl#hasExactSynonym":["GPCR signalling pathway","G protein coupled receptor protein signalling pathway","G-protein-coupled receptor protein signalling pathway","G-protein coupled receptor protein signal transduction","G protein coupled receptor protein signaling pathway","GPCR signaling pathway","G-protein coupled receptor signalling pathway","G-protein coupled receptor protein signaling pathway"],"http://www.geneontology.org/formats/oboInOwl#inSubset":["http://purl.obolibrary.org/obo/go#goslim_drosophila"],"http://www.w3.org/2000/01/rdf-schema#label":["G protein-coupled receptor signaling pathway"],"http://purl.obolibrary.org/obo/IAO_0000115":["The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane."],"http://www.geneontology.org/formats/oboInOwl#hasOBONamespace":["biological_process"],"http://purl.obolibrary.org/obo/RO_0002224":["http://purl.obolibrary.org/obo/GO_0004930"],"http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym":["dimeric G-protein coupled receptor signalling pathway","G-protein coupled receptor signaling pathway via GPCR dimer","dimeric G-protein coupled receptor signaling pathway"],"http://www.w3.org/2004/02/skos/core#notation":["GO:0007186"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/GO_0007165"],"http://www.geneontology.org/formats/oboInOwl#hasDbXref":["Reactome:R-HSA-373076","Reactome:R-HSA-388396"],"http://www.geneontology.org/formats/oboInOwl#id":["GO:0007186"]},"@id":"http://purl.obolibrary.org/obo/GO_0007186","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186","ontology":"https://data.bioontology.org/ontologies/CL","children":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186/children","parents":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186/parents","descendants":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186/descendants","ancestors":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186/ancestors","instances":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186/instances","tree":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186/tree","notes":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186/notes","mappings":"https://data.bioontology.org/ontologies/CL/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186/mappings","ui":"http://bioportal.bioontology.org/ontologies/CL?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FGO_0007186","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}