<?xml version="1.0"?>
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7
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2
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0
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<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000056</classIRI>
<classLabel>evidence information from clinical study</classLabel>
<deletedAxiom>&apos;evidence information from clinical study&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;drug product&apos;)))</deletedAxiom>
<newAxiom>&apos;evidence information from clinical study&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical entity&apos; or &apos;drug product&apos;))))</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000074</classIRI>
<classLabel>evidence information from randomized drug-drug interaction clinical trial</classLabel>
<deletedAxiom>&apos;evidence information from randomized drug-drug interaction clinical trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some &apos;group randomization&apos;) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;)))))</deletedAxiom>
<newAxiom>&apos;evidence information from randomized drug-drug interaction clinical trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some &apos;group randomization&apos;) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
((&apos;chemical entity&apos; or &apos;drug product&apos;) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
((&apos;chemical entity&apos; or &apos;drug product&apos;) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;)))))</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000075</classIRI>
<classLabel>evidence information from pharmacokinetic trial</classLabel>
<deletedAxiom>&apos;evidence information from pharmacokinetic trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some &apos;pharmacokinetic process&apos;) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;drug product&apos;)))</deletedAxiom>
<newAxiom>&apos;evidence information from pharmacokinetic trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some &apos;pharmacokinetic process&apos;) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical entity&apos; or &apos;drug product&apos;))))</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000076</classIRI>
<classLabel>evidence information from genotyped pharmacokinetic trial</classLabel>
<deletedAxiom>&apos;evidence information from genotyped pharmacokinetic trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some &apos;pharmacokinetic process&apos;) and (&apos;has part&apos; some &apos;genotyping&apos;) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;drug product&apos;)))</deletedAxiom>
<newAxiom>&apos;evidence information from genotyped pharmacokinetic trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some &apos;pharmacokinetic process&apos;) and (&apos;has part&apos; some &apos;genotyping&apos;) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical entity&apos; or &apos;drug product&apos;))))</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000071</classIRI>
<classLabel>evidence information from drug-drug interaction clinical trial</classLabel>
<deletedAxiom>&apos;evidence information from drug-drug interaction clinical trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;)))))</deletedAxiom>
<newAxiom>&apos;evidence information from drug-drug interaction clinical trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
((&apos;chemical entity&apos; or &apos;drug product&apos;) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
((&apos;chemical entity&apos; or &apos;drug product&apos;) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;)))))</newAxiom>
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<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000072</classIRI>
<classLabel>evidence information from non-randomized drug-drug interaction clinical trial</classLabel>
<deletedAxiom>&apos;evidence information from non-randomized drug-drug interaction clinical trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (not (&apos;has part&apos; some &apos;group randomization&apos;)) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;)))))</deletedAxiom>
<newAxiom>&apos;evidence information from non-randomized drug-drug interaction clinical trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (not (&apos;has part&apos; value &apos;group randomization&apos;)) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
((&apos;chemical entity&apos; or &apos;drug product&apos;) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
((&apos;chemical entity&apos; or &apos;drug product&apos;) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;)))))</newAxiom>
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<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000073</classIRI>
<classLabel>evidence information from parallel groups drug-drug interaction clinical trial&apos;</classLabel>
<deletedAxiom>&apos;evidence information from parallel groups drug-drug interaction clinical trial&apos;&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (not (&apos;has part&apos; some &apos;group randomization&apos;)) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some 
(&apos;clinical study design&apos; and (&apos;has part&apos; some &apos;parallel group design&apos;)))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;)))))</deletedAxiom>
<newAxiom>&apos;evidence information from parallel groups drug-drug interaction clinical trial&apos;&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (not (&apos;has part&apos; some &apos;group randomization&apos;)) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some 
(&apos;clinical study design&apos; and (&apos;has part&apos; some &apos;parallel group design&apos;)))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
((&apos;chemical entity&apos; or &apos;drug product&apos;) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
((&apos;chemical entity&apos; or &apos;drug product&apos;) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;)))))</newAxiom>
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<classLabel>evidence information from CYP450 human microsome drug metabolism inhibition experiment</classLabel>
<newAxiom>'evidence information from CYP450 human microsome drug metabolism inhibition experiment' EquivalentTo 'evidence information content entity' and (http://purl.obolibrary.org/obo/IAO_0000136 some 
('assay' and ('has part' some 
('negative regulation of biological process' and ('has participant' some 'cytochrome P450'))) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some 'in vitro design')) and (http://purl.obolibrary.org/obo/OBI_0000293 some 'tissue specimen') and (http://purl.obolibrary.org/obo/OBI_0000293 some 
('chemical substance' and ('part of' some 
('metabolite' or 'drug product')) and ('participates in' some 'metabolic process')))))</newAxiom>
<newAxiom>'evidence information from CYP450 human microsome drug metabolism inhibition experiment' SubClassOf 'evidence information content entity'</newAxiom>
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<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000080</classIRI>
<classLabel>evidence information from CYP450 recombinant drug metabolism inhibition experiment</classLabel>
<newAxiom>'evidence information from CYP450 recombinant drug metabolism inhibition experiment' EquivalentTo 'evidence information content entity' and (http://purl.obolibrary.org/obo/IAO_0000136 some 
('assay' and ('has part' some 
('negative regulation of biological process' and ('has participant' some 'cytochrome P450'))) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some 'in vitro design')) and (http://purl.obolibrary.org/obo/OBI_0000293 some 'cell line') and (http://purl.obolibrary.org/obo/OBI_0000293 some 
('chemical substance' and ('part of' some 
('metabolite' or 'drug product')) and ('participates in' some 'metabolic process')))))</newAxiom>
<newAxiom>'evidence information from CYP450 recombinant drug metabolism inhibition experiment' SubClassOf 'evidence information content entity'</newAxiom>
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