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(&apos;assay&apos; and (&apos;has part&apos; some 
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(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical substance&apos; and ((&apos;part of&apos; some &apos;drug product&apos;) or (http://purl.obolibrary.org/obo/RO_0000053 some &apos;metabolite&apos;)) and (&apos;participates in&apos; some 
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(&apos;specimen collection process&apos; and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;Homo sapiens&apos;)))))))</newAxiom>
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<newAxiom>&apos;evidence information from CYP450 recombinant drug metabolism inhibition experiment&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;cell line&apos;) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
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(&apos;assay&apos; and ((&apos;has part&apos; some 
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(&apos;cell line&apos; or &apos;tissue specimen&apos;)))))</deletedAxiom>
<newAxiom>&apos;evidence information from CYP450 drug metabolism identification experiment&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
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<newAxiom>&apos;evidence information from CYP450 recombinant drug metabolism identification experiment&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;cell line&apos;) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
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(&apos;assay&apos; and (&apos;has part&apos; some 
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<newAxiom>&apos;evidence information from CYP450 recombinant drug metabolism identification experiment using chemical inhibitors&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
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<newAxiom>&apos;evidence information from CYP450 human microsome drug metabolism identification experiment&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
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(&apos;chemical substance&apos; and ((&apos;part of&apos; some &apos;drug product&apos;) or (http://purl.obolibrary.org/obo/RO_0000053 some &apos;metabolite&apos;)) and (&apos;participates in&apos; some 
(&apos;metabolic process&apos; and (&apos;has participant&apos; some &apos;cytochrome P450&apos;))))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;tissue specimen&apos; and (&apos;is_specified_output_of&apos; some 
(&apos;specimen collection process&apos; and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;Homo sapiens&apos;)))))))</newAxiom>
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<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000068</classIRI>
<classLabel>evidence information from CYP450 human microsome drug metabolism identification experiment using chemical inhibitors</classLabel>
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(&apos;assay&apos; and (&apos;has part&apos; some 
(&apos;metabolic process&apos; and (&apos;has participant&apos; some &apos;cytochrome P450&apos;))) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical substance&apos; and (not (&apos;immunoglobulin complex, circulating&apos;)) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;inhibitor&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical substance&apos; and (&apos;part of&apos; some 
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(&apos;tissue specimen&apos; and (&apos;is_specified_output_of&apos; some 
(&apos;specimen collection process&apos; and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;Homo sapiens&apos;)))))))</deletedAxiom>
<newAxiom>&apos;evidence information from CYP450 human microsome drug metabolism identification experiment using chemical inhibitors&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical substance&apos; and ((&apos;part of&apos; some &apos;drug product&apos;) or (http://purl.obolibrary.org/obo/RO_0000053 some &apos;metabolite&apos;)) and (&apos;participates in&apos; some 
(&apos;metabolic process&apos; and (&apos;has participant&apos; some &apos;cytochrome P450&apos;))))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical substance&apos; and (not (&apos;immunoglobulin complex, circulating&apos;)) and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;inhibitor&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;tissue specimen&apos; and (&apos;is_specified_output_of&apos; some 
(&apos;specimen collection process&apos; and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;Homo sapiens&apos;)))))))</newAxiom>
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<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000069</classIRI>
<classLabel>evidence information from CYP450 human microsome drug metabolism identification experiment using antibody inhibitors</classLabel>
<deletedAxiom>&apos;evidence information from CYP450 human microsome drug metabolism identification experiment using antibody inhibitors&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some 
(&apos;metabolic process&apos; and (&apos;has participant&apos; some &apos;cytochrome P450&apos;))) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical substance&apos; and (&apos;part of&apos; some 
(&apos;metabolite&apos; or &apos;drug product&apos;)) and (&apos;participates in&apos; some &apos;metabolic process&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;immunoglobulin complex, circulating&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;inhibitor&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;tissue specimen&apos; and (&apos;is_specified_output_of&apos; some 
(&apos;specimen collection process&apos; and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;Homo sapiens&apos;)))))))</deletedAxiom>
<newAxiom>&apos;evidence information from CYP450 human microsome drug metabolism identification experiment using antibody inhibitors&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical substance&apos; and ((&apos;part of&apos; some &apos;drug product&apos;) or (http://purl.obolibrary.org/obo/RO_0000053 some &apos;metabolite&apos;)) and (&apos;participates in&apos; some 
(&apos;metabolic process&apos; and (&apos;has participant&apos; some &apos;cytochrome P450&apos;))))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;immunoglobulin complex, circulating&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;inhibitor&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;tissue specimen&apos; and (&apos;is_specified_output_of&apos; some 
(&apos;specimen collection process&apos; and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;Homo sapiens&apos;)))))))</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000075</classIRI>
<classLabel>evidence information from pharmacokinetic trial</classLabel>
<deletedAxiom>&apos;evidence information from pharmacokinetic trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some &apos;pharmacokinetic process&apos;) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical entity&apos; or &apos;drug product&apos;))))</deletedAxiom>
<newAxiom>&apos;evidence information from pharmacokinetic trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;organism&apos; and (&apos;participates in&apos; some &apos;pharmacokinetic process&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical entity&apos; or &apos;drug product&apos;))))</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000076</classIRI>
<classLabel>evidence information from genotyped pharmacokinetic trial</classLabel>
<deletedAxiom>&apos;evidence information from genotyped pharmacokinetic trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some &apos;pharmacokinetic process&apos;) and (&apos;has part&apos; some &apos;genotyping&apos;) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical entity&apos; or &apos;drug product&apos;))))</deletedAxiom>
<newAxiom>&apos;evidence information from genotyped pharmacokinetic trial&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;clinical study design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;organism&apos; and (&apos;participates in&apos; some &apos;pharmacokinetic process&apos;) and (&apos;participates in&apos; some &apos;genotyping&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical entity&apos; or &apos;drug product&apos;))))</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000070</classIRI>
<classLabel>evidence information from CYP450 metabolic enzyme inhibition experiment</classLabel>
<deletedAxiom>&apos;evidence information from CYP450 metabolic enzyme inhibition experiment&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (&apos;has part&apos; some 
(&apos;negative regulation of biological process&apos; and (&apos;has participant&apos; some &apos;cytochrome P450&apos;))) and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical substance&apos; and (&apos;part of&apos; some 
(&apos;metabolite&apos; or &apos;drug product&apos;)) and (&apos;participates in&apos; some &apos;metabolic process&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;cell line&apos; or &apos;tissue specimen&apos;))))</deletedAxiom>
<newAxiom>&apos;evidence information from CYP450 metabolic enzyme inhibition experiment&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
(&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;in vitro design&apos;)) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;chemical substance&apos; and ((&apos;part of&apos; some &apos;drug product&apos;) or (http://purl.obolibrary.org/obo/RO_0000053 some &apos;metabolite&apos;)) and (&apos;participates in&apos; some 
(http://purl.obolibrary.org/obo/GO_0009892 and (&apos;has participant&apos; some &apos;cytochrome P450&apos;))))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;cell line&apos; or &apos;tissue specimen&apos;))))</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000078</classIRI>
<classLabel>evidence information from observational pharmacokinetic study</classLabel>
<deletedAxiom>&apos;evidence information from observational pharmacokinetic study&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
((&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;observation design&apos;))) and (&apos;has part&apos; some &apos;pharmacokinetic process&apos;) and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;drug product&apos;)))</deletedAxiom>
<newAxiom>&apos;evidence information from observational pharmacokinetic study&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
((&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;observation design&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some &apos;drug product&apos;) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;organism&apos; and (&apos;participates in&apos; some &apos;pharmacokinetic process&apos;)))))</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/DIDEO_00000079</classIRI>
<classLabel>evidence information from observational drug-drug interaction study</classLabel>
<deletedAxiom>&apos;evidence information from observational drug-drug interaction study&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
((&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;observation design&apos;))) and (&apos;has part&apos; some &apos;pharmacokinetic process&apos;) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;)))))</deletedAxiom>
<newAxiom>&apos;evidence information from observational drug-drug interaction study&apos; EquivalentTo &apos;evidence information content entity&apos; and (http://purl.obolibrary.org/obo/IAO_0000136 some 
((&apos;assay&apos; and (http://purl.obolibrary.org/obo/BFO_0000055 some (http://purl.obolibrary.org/obo/RO_0000059 some &apos;observation design&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;object drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;drug product&apos; and (http://purl.obolibrary.org/obo/RO_0000053 some &apos;precipitant drug role&apos;))) and (http://purl.obolibrary.org/obo/OBI_0000293 some 
(&apos;organism&apos; and (&apos;participates in&apos; some &apos;pharmacokinetic process&apos;)))))</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009892</classIRI>
<classLabel>negative regulation of metabolic process</classLabel>
<newAxiom>'negative regulation of metabolic process' EquivalentTo 'biological regulation' and ('negatively regulates' some 'metabolic process')</newAxiom>
<newAxiom>'negative regulation of metabolic process' SubClassOf 'biological regulation'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>