0 81 0 http://purl.obolibrary.org/obo/OBI_0001148 gene knock out 'gene knock out' SubClassOf 'genetic transformation' http://purl.obolibrary.org/obo/OBI_1000024 cell pellet 'cell pellet' SubClassOf 'processed material' http://purl.obolibrary.org/obo/DIDEO_00000123 probe subtrate role 'probe subtrate role' SubClassOf http://purl.obolibrary.org/obo/BFO_0000023 http://purl.obolibrary.org/obo/CHEBI_35217 alkaline earth coordination entity 'alkaline earth coordination entity' SubClassOf 'main-group coordination entity' http://purl.obolibrary.org/obo/CHEBI_34480 7-ethoxyresorufin '7-ethoxyresorufin' SubClassOf 'phenoxazine' http://purl.obolibrary.org/obo/OBI_0001152 transfection 'transfection' SubClassOf 'genetic transformation' http://purl.obolibrary.org/obo/OBI_0302886 centrifugation 'centrifugation' SubClassOf 'material component separation' http://purl.obolibrary.org/obo/MOP_0001364 demethylation 'demethylation' SubClassOf http://purl.obolibrary.org/obo/BFO_0000015 http://purl.obolibrary.org/obo/OBI_0000192 microtiter plate 'microtiter plate' SubClassOf 'container' http://purl.obolibrary.org/obo/CHEBI_51234 magnesium halide 'magnesium halide' SubClassOf 'magnesium coordination entity' http://purl.obolibrary.org/obo/CLO_0002421 CHO cell 'CHO cell' SubClassOf 'cell line cell' http://purl.obolibrary.org/obo/CHEBI_6931 Midazolam 'Midazolam' SubClassOf 'organic heterocyclic compound' http://purl.obolibrary.org/obo/DIDEO_00000162 human liver S9 fraction 'human liver S9 fraction' SubClassOf 'processed material' http://purl.obolibrary.org/obo/DIDEO_00000163 individual human intestinal microsomal fraction 'individual human intestinal microsomal fraction' SubClassOf 'processed material' http://purl.obolibrary.org/obo/DIDEO_00000164 pooled human liver microsomal fraction 'pooled human liver microsomal fraction' SubClassOf 'processed material' http://purl.obolibrary.org/obo/DIDEO_00000165 individual human liver microsomal fraction 'individual human liver microsomal fraction' SubClassOf 'processed material' http://purl.obolibrary.org/obo/DIDEO_00000160 human liver cytosolic fraction 'human liver cytosolic fraction' SubClassOf 'processed material' http://purl.obolibrary.org/obo/DIDEO_00000161 human intestine cytosolic fraction 'human intestine cytosolic fraction' SubClassOf 'processed material' http://purl.obolibrary.org/obo/DIDEO_00000166 pooled human intestinal microsomal fraction 'pooled human intestinal microsomal fraction' SubClassOf 'processed material' http://purl.obolibrary.org/obo/DIDEO_00000167 human intestine S9 fraction 'human intestine S9 fraction' SubClassOf 'processed material' http://purl.obolibrary.org/obo/DIDEO_00000168 baculovirus-insect recombinant protein production host cell 'baculovirus-insect recombinant protein production host cell' SubClassOf 'cultured cell' http://purl.obolibrary.org/obo/DIDEO_00000169 E. coli recombinant protein production host cell 'E. coli recombinant protein production host cell' EquivalentTo 'cultured cell' and 'Escherichia coli' and (http://purl.obolibrary.org/obo/RO_0000087 some 'recombinant protein production host role') 'E. coli recombinant protein production host cell' SubClassOf 'cultured cell' http://purl.obolibrary.org/obo/CHEBI_25970 phenoxazine 'phenoxazine' SubClassOf 'organic heterotricyclic compound' http://purl.obolibrary.org/obo/DIDEO_00000173 nifedipine dehydrogenation 'nifedipine dehydrogenation' SubClassOf 'dehydrogenation' http://purl.obolibrary.org/obo/DIDEO_00000174 bufuralol 1'-hydroxylation 'bufuralol 1'-hydroxylation' SubClassOf 'hydroxylation' http://purl.obolibrary.org/obo/DIDEO_00000175 omeprazole 5-hydroxylation 'omeprazole 5-hydroxylation' EquivalentTo 'hydroxylation' and ('has input' some 'omeprazole') and ('has output' some '5'-hydroxyomeprazole') 'omeprazole 5-hydroxylation' SubClassOf 'hydroxylation' http://purl.obolibrary.org/obo/DIDEO_00000176 bupropion hydroxylation 'bupropion hydroxylation' SubClassOf 'hydroxylation' http://purl.obolibrary.org/obo/DIDEO_00000170 percent inhibition 'percent inhibition' SubClassOf http://purl.obolibrary.org/obo/IAO_0000109 http://purl.obolibrary.org/obo/DIDEO_00000171 midazolam 1'-hydroxylation 'midazolam 1'-hydroxylation' SubClassOf 'hydroxylation' http://purl.obolibrary.org/obo/DIDEO_00000172 7-ethoxyresorufin O-deethylation '7-ethoxyresorufin O-deethylation' EquivalentTo 'deethylation' and ('has input' some '7-ethoxyresorufin') and ('has output' some 'resorufin') '7-ethoxyresorufin O-deethylation' SubClassOf 'deethylation' http://purl.obolibrary.org/obo/OBI_0000029 centrifuge pellet role 'centrifuge pellet role' SubClassOf http://purl.obolibrary.org/obo/BFO_0000023 http://purl.obolibrary.org/obo/DIDEO_00000177 paclitaxel 6-alpha hydroxylation 'paclitaxel 6-alpha hydroxylation' SubClassOf 'hydroxylation' http://purl.obolibrary.org/obo/DIDEO_00000178 phenacetin O-deethylation 'phenacetin O-deethylation' SubClassOf 'deethylation' http://purl.obolibrary.org/obo/DIDEO_00000179 coumarin 7-hydroxylation 'coumarin 7-hydroxylation' SubClassOf 'hydroxylation' http://purl.obolibrary.org/obo/APOLLO_SV_00000032 count 'count' SubClassOf http://purl.obolibrary.org/obo/IAO_0000109 http://purl.obolibrary.org/obo/CHEBI_33240 coordination entity 'coordination entity' SubClassOf 'heteroatomic molecular entity' http://purl.obolibrary.org/obo/CHEBI_16474 NADPH 'NADPH' SubClassOf 'heteroarene' http://purl.obolibrary.org/obo/CHEBI_17200 UDP-alpha-D-glucuronic acid 'UDP-alpha-D-glucuronic acid' SubClassOf 'heteroarene' http://purl.obolibrary.org/obo/MOP_0001385 deethylation 'deethylation' SubClassOf http://purl.obolibrary.org/obo/BFO_0000015 http://purl.obolibrary.org/obo/OBI_0000034 supernatant role 'supernatant role' SubClassOf http://purl.obolibrary.org/obo/BFO_0000023 http://purl.obolibrary.org/obo/CHEBI_16908 NADH 'NADH' SubClassOf 'NAD' http://purl.obolibrary.org/obo/CHEBI_7772 omeprazole 'omeprazole' SubClassOf 'racemate' http://purl.obolibrary.org/obo/OBI_0600043 genetic transformation 'genetic transformation' SubClassOf 'material processing' http://purl.obolibrary.org/obo/OBI_0000968 device 'device' SubClassOf 'processed material' http://purl.obolibrary.org/obo/OBI_0000967 container 'container' SubClassOf 'device' http://purl.obolibrary.org/obo/ERO_0000630 nucleic acid reagent 'nucleic acid reagent' SubClassOf http://purl.obolibrary.org/obo/BFO_0000040 http://purl.obolibrary.org/obo/OBI_0000571 manufacturer role 'manufacturer role' SubClassOf http://purl.obolibrary.org/obo/BFO_0000023 http://purl.obolibrary.org/obo/CHEBI_17980 3'-phospho-5'-adenylyl sulfate '3'-phospho-5'-adenylyl sulfate' SubClassOf 'ester' http://purl.obolibrary.org/obo/OBI_0600014 material component separation 'material component separation' SubClassOf 'material processing' http://purl.obolibrary.org/obo/CHEBI_13389 NAD 'NAD' SubClassOf 'heteroarene' http://purl.obolibrary.org/obo/CHEBI_6636 magnesium dichloride 'magnesium dichloride' SubClassOf 'magnesium halide' http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation 'hydroxylation' SubClassOf http://purl.obolibrary.org/obo/BFO_0000015 http://purl.obolibrary.org/obo/DIDEO_00000184 number of doses in a day 'number of doses in a day' SubClassOf 'count' http://purl.obolibrary.org/obo/DIDEO_00000185 Hep G2 cell 'Hep G2 cell' SubClassOf 'cell line cell' http://purl.obolibrary.org/obo/DIDEO_00000186 CHO transfected cell 'CHO transfected cell' EquivalentTo 'CHO cell' and ('is_specified_output_of' some 'transfection') 'CHO transfected cell' SubClassOf 'CHO cell' http://purl.obolibrary.org/obo/DIDEO_00000187 Hep G2 transfected cell 'Hep G2 transfected cell' SubClassOf 'Hep G2 cell' 'Hep G2 transfected cell' EquivalentTo 'Hep G2 cell' and ('is_specified_output_of' some 'transfection') http://purl.obolibrary.org/obo/DIDEO_00000180 testosterone 6-beta-hydroxylation 'testosterone 6-beta-hydroxylation' SubClassOf 'hydroxylation' http://purl.obolibrary.org/obo/DIDEO_00000181 dextromethorphan O-demethylation 'dextromethorphan O-demethylation' SubClassOf 'demethylation' http://purl.obolibrary.org/obo/DIDEO_00000182 diclofenac 4'-hydroxylation 'diclofenac 4'-hydroxylation' SubClassOf 'hydroxylation' http://purl.obolibrary.org/obo/DIDEO_00000183 recombinant protein production host role 'recombinant protein production host role' SubClassOf 'target of material addition role' http://purl.obolibrary.org/obo/NCBITaxon_562 Escherichia coli 'Escherichia coli' SubClassOf 'organism' http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity 'heteroatomic molecular entity' SubClassOf 'polyatomic entity' http://purl.obolibrary.org/obo/DIDEO_00000188 siRNA knockout Caco-2 cell 'siRNA knockout Caco-2 cell' SubClassOf 'Caco-2 cell' 'siRNA knockout Caco-2 cell' EquivalentTo 'Caco-2 cell' and ('is_specified_output_of' some ('gene knock out' and (http://purl.obolibrary.org/obo/OBI_0000293 some 'siRNA oligonucleotide'))) http://purl.obolibrary.org/obo/DIDEO_00000189 293 transfected cell '293 transfected cell' SubClassOf '293-derived cell' '293 transfected cell' EquivalentTo '293-derived cell' and ('is_specified_output_of' some 'transfection') http://purl.obolibrary.org/obo/CLO_0037237 293-derived cell '293-derived cell' SubClassOf 'cell line cell' http://purl.obolibrary.org/obo/CHEBI_63840 5'-hydroxyomeprazole '5'-hydroxyomeprazole' SubClassOf 'benzimidazoles' http://purl.obolibrary.org/obo/DIDEO_00000190 number of liver donors 'number of liver donors' SubClassOf 'count' http://purl.obolibrary.org/obo/MOP_0000590 dehydrogenation 'dehydrogenation' SubClassOf http://purl.obolibrary.org/obo/BFO_0000015 http://purl.obolibrary.org/obo/OBI_0000094 material processing 'material processing' SubClassOf http://purl.obolibrary.org/obo/OBI_0000011 http://purl.obolibrary.org/obo/OBI_0001180 half maximal effective concentration (EC50) 'half maximal effective concentration (EC50)' SubClassOf http://purl.obolibrary.org/obo/IAO_0000032 http://purl.obolibrary.org/obo/CHEBI_16856 glutathione 'glutathione' SubClassOf 'organooxygen compound' http://purl.obolibrary.org/obo/OBI_0001191 half maximal inhibitory concentration (IC50) 'half maximal inhibitory concentration (IC50)' SubClassOf http://purl.obolibrary.org/obo/IAO_0000032 http://purl.obolibrary.org/obo/CHEBI_51602 resorufin 'resorufin' SubClassOf 'phenoxazine' http://purl.obolibrary.org/obo/CHEBI_22715 benzimidazoles 'benzimidazoles' SubClassOf 'organic heterobicyclic compound' http://purl.obolibrary.org/obo/CHEBI_36562 main-group coordination entity 'main-group coordination entity' SubClassOf 'coordination entity' http://purl.obolibrary.org/obo/OBI_0000444 target of material addition role 'target of material addition role' SubClassOf http://purl.obolibrary.org/obo/BFO_0000023 http://purl.obolibrary.org/obo/CHEBI_33976 magnesium coordination entity 'magnesium coordination entity' SubClassOf 'alkaline earth coordination entity' http://purl.obolibrary.org/obo/ERO_0001205 RNA oligonucleotide 'RNA oligonucleotide' SubClassOf 'RNA reagent' http://purl.obolibrary.org/obo/ERO_0001206 RNA interference oligonucleotide 'RNA interference oligonucleotide' SubClassOf 'RNA oligonucleotide' http://purl.obolibrary.org/obo/ERO_0001209 siRNA oligonucleotide 'siRNA oligonucleotide' SubClassOf 'RNA interference oligonucleotide' http://purl.obolibrary.org/obo/ERO_0001202 RNA reagent 'RNA reagent' SubClassOf 'nucleic acid reagent'