{"id":"http://purl.obolibrary.org/obo/CHEBI_18332","prefLabel":"L-thyroxine","synonym":["C15H11I4NO4","3,5,3',5'-tetraiodo-L-thyronine","4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine","L-T4","3,5,3',5'-TETRAIODO-L-THYRONINE","3,3',5,5'-tetraiodo-L-thyronine","(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid","L-Thyroxine","levothyroxine","Levothyroxin","T4","O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine","L-thyroxine"],"prefixIRI":"obo2:CHEBI_18332","label":["L-thyroxine"],"subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"],"parents":[{"id":"http://purl.obolibrary.org/obo/dinto_000055","prefLabel":"pharmacological entity","prefixIRI":"obo2:dinto_000055","label":["pharmacological entity"],"definition":["This class imports chemical entities from the ChEBI ontology that have a relationship 'has role' with the class 'drug' in this ontology and other chemical entities included in the pharmacological database DrugBank (but not in ChEBI).\nTherefore all subclasses of the class 'pharmacological entity' share they capacity to produce some pharmacological activity within a biological system."],"subClassOf":["http://purl.obolibrary.org/obo/CHEBI_24431"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/dinto_000055","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"definition":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://purl.obolibrary.org/obo#DBSynonym":["thx","laevothyroxinum","thyroxine iodine","(-)-thyroxine","levothyroxine sodium","levothyroxin","t4 levothyroxine","o-(4-hydroxy-3,5-diidophenyl)-3,5-diiodo-l-tyrosine","l-thryoxin","tetraiodothyronine","l-thyroxine","3,3',5,5'-tetraiodo-l-thyronine","levo-t"],"http://purl.obolibrary.org/obo#ATCCode":["H03AA01"],"https://data.bioontology.org/metadata/def/prefLabel":["L-thyroxine"],"http://purl.obolibrary.org#Definition":["The L-enantiomer of thyroxine."],"http://purl.obolibrary.org/obo#altId":["CHEBI:45848","CHEBI:13177","CHEBI:7663","CHEBI:21406"],"http://purl.obolibrary.org/obo/dinto_000303":["http://purl.obolibrary.org/obo/dinto_3533","http://purl.obolibrary.org/obo/dinto_1129"],"http://purl.obolibrary.org/obo/dinto_000406":["http://purl.obolibrary.org/obo/dinto_1440"],"http://purl.obolibrary.org/obo/dinto_000430":["http://purl.obolibrary.org/obo/dinto_3533","http://purl.obolibrary.org/obo/dinto_1129"],"http://purl.obolibrary.org/obo/dinto_000404":["http://purl.obolibrary.org/obo/dinto_2915","http://purl.obolibrary.org/obo/dinto_1221"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://purl.obolibrary.org/obo/dinto_000154":["http://purl.obolibrary.org/obo/CHEBI_60311","http://purl.obolibrary.org/obo/CHEBI_50671"],"http://purl.obolibrary.org/obo#InChIKey":["InChIKey=XUIIKFGFIJCVMT-LBPRGKRZSA-N"],"http://purl.obolibrary.org/obo/dinto_000423":["http://purl.obolibrary.org/obo/dinto_0901"],"http://purl.obolibrary.org/obo#AHFScode":["68:36.04"],"http://purl.obolibrary.org/obo#Synonym":["C15H11I4NO4","3,5,3',5'-tetraiodo-L-thyronine","4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine","L-T4","3,5,3',5'-TETRAIODO-L-THYRONINE","3,3',5,5'-tetraiodo-L-thyronine","(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid","L-Thyroxine","levothyroxine","Levothyroxin","T4","O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine","L-thyroxine"],"http://purl.obolibrary.org/obo#xref":["Drugs.com:http://www.drugs.com/levothyroxine.html","DrugBank:DB00451","PDBeChem:T44","Wikipedia:http://en.wikipedia.org/wiki/Levothyroxine","PubChem Compound:5819","PubChem Substance:46507672","RxList:http://www.rxlist.com/cgi/generic/levothy.htm","Beilstein:7002831","KEGG COMPOUND:C01829","CiteXplore:15206581","ChemSpider:5614","CASRN:51-48-9","ChEMBL:569690","Drugs Product Database (DPD):2245948","Wikipedia:Levothyroxine","National Drug Code Directory:0781-5180-01","Guide To Pharmacology:2635","PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/syn1421.shtml","IUPHAR:2635","ChEBI:18332","Beilstein:2228515","PharmGKB:PA450221"],"http://purl.obolibrary.org/obo#CASRN":["51-48-9"],"https://data.bioontology.org/metadata/prefixIRI":["obo2:CHEBI_18332"],"http://purl.obolibrary.org/obo/dinto_000426":["http://purl.obolibrary.org/obo/dinto_1822"],"http://purl.obolibrary.org/obo/dinto_000408":["http://purl.obolibrary.org/obo/dinto_1573","http://purl.obolibrary.org/obo/dinto_1805","http://purl.obolibrary.org/obo/dinto_2129","http://purl.obolibrary.org/obo/dinto_2019","http://purl.obolibrary.org/obo/dinto_1815","http://purl.obolibrary.org/obo/dinto_1824","http://purl.obolibrary.org/obo/dinto_1987","http://purl.obolibrary.org/obo/dinto_0505","http://purl.obolibrary.org/obo/dinto_0217"],"http://purl.obolibrary.org/obo#SMILES":["N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O","N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O"],"http://purl.obolibrary.org/obo/dinto_000499":["http://purl.obolibrary.org/obo/CHEBI_4551","http://purl.obolibrary.org/obo/dinto_DB00893","http://purl.obolibrary.org/obo/CHEBI_53766","http://purl.obolibrary.org/obo/CHEBI_8772","http://purl.obolibrary.org/obo/dinto_DB00258","http://purl.obolibrary.org/obo/CHEBI_133809","http://purl.obolibrary.org/obo/dinto_DB00364","http://purl.obolibrary.org/obo/CHEBI_10033","http://purl.obolibrary.org/obo/dinto_DB01164","http://purl.obolibrary.org/obo/CHEBI_4513","http://purl.obolibrary.org/obo/dinto_DB01373","http://purl.obolibrary.org/obo/CHEBI_59602","http://purl.obolibrary.org/obo/dinto_DB01592","http://purl.obolibrary.org/obo/dinto_DB01432"],"http://www.w3.org/2000/01/rdf-schema#label":["L-thyroxine"],"http://purl.obolibrary.org/obo#DBname":["levothyroxine"],"http://purl.obolibrary.org/obo#InChI":["InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1"],"http://purl.obolibrary.org/obo#DBBrand":["levolet","thyratabs","thyroxin","thyroxinal","synthroid","levothyrox","thyroxevan","letter","synthroid sodium","thyreoideum","levothroid","unithroid","oroxine","novothyrox","thyro-tabs","eltroxin","levoxyl","laevoxin","levaxin","euthyrox","thyrax"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"]},"@id":"http://purl.obolibrary.org/obo/CHEBI_18332","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_18332","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007fbd5ffec6e8 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-0083660248b7/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}