{"id":"http://purl.obolibrary.org/obo/CHEBI_4392","prefLabel":"demeclocycline","synonym":["DMCT","demeclocycline","demeclocyclinum","7-chloro-6-demethyltetracycline","[4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide","C21H21ClN2O8","demeclociclina","Demeclocycline","DMCTC","(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide","demethylchlortetracycline","6-demethyl-7-chlorotetracycline"],"prefixIRI":"obo2:CHEBI_4392","label":["demeclocycline"],"subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"],"parents":[{"id":"http://purl.obolibrary.org/obo/dinto_000055","prefLabel":"pharmacological entity","prefixIRI":"obo2:dinto_000055","label":["pharmacological entity"],"definition":["This class imports chemical entities from the ChEBI ontology that have a relationship 'has role' with the class 'drug' in this ontology and other chemical entities included in the pharmacological database DrugBank (but not in ChEBI).\nTherefore all subclasses of the class 'pharmacological entity' share they capacity to produce some pharmacological activity within a biological system."],"subClassOf":["http://purl.obolibrary.org/obo/CHEBI_24431"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/dinto_000055","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"definition":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://purl.obolibrary.org/obo#DBSynonym":["demethylchlortetracyclin","demeclocyclinum [inn-latin]","demethylchlortetracyclinum","7-chloro-6-demethyltetracycline","methylchlorotetracycline","demeclocycline [usan:ban]","dmct","demethylchlorotetracycline","demeclociclina [inn-spanish]","tri-demethylchlortetracycline","6-demethylchlorotetracycline","demethylchlortetracycline","6-demethyl-7-chlorotetracycline"],"http://purl.obolibrary.org/obo#ATCCode":["J01AA01","D06AA01"],"https://data.bioontology.org/metadata/def/prefLabel":["demeclocycline"],"http://purl.obolibrary.org#Definition":["Tetracycline which lacks the methyl substituent at position 7 and in which the hydrogen para- to the phenolic hydroxy group is substituted by chlorine. Like tetracycline, it is an antibiotic, but being excreted more slowly, effective blood levels are maintained for longer. It is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective."],"http://purl.obolibrary.org/obo#altId":["CHEBI:554084"],"http://purl.obolibrary.org/obo/dinto_000159":["http://purl.obolibrary.org/obo/OAE_0000388","http://purl.obolibrary.org/obo/OAE_0000449","http://purl.obolibrary.org/obo/OAE_0000597","http://purl.obolibrary.org/obo/OAE_0000377","http://purl.obolibrary.org/obo/OAE_0000376","http://purl.obolibrary.org/obo/OAE_0000195","http://purl.obolibrary.org/obo/OAE_0000210","http://purl.obolibrary.org/obo/OAE_0001448","http://purl.obolibrary.org/obo/OAE_0000600","http://purl.obolibrary.org/obo/OAE_0001365","http://purl.obolibrary.org/obo/OAE_0000920","http://purl.obolibrary.org/obo/OAE_0000403","http://purl.obolibrary.org/obo/OAE_0001026","http://purl.obolibrary.org/obo/OAE_0000601","http://purl.obolibrary.org/obo/OAE_0001101","http://purl.obolibrary.org/obo/OAE_0000086","http://purl.obolibrary.org/obo/OAE_0000645","http://purl.obolibrary.org/obo/OAE_0000584","http://purl.obolibrary.org/obo/OAE_0000341","http://purl.obolibrary.org/obo/OAE_0000607","http://purl.obolibrary.org/obo/OAE_0001145","http://purl.obolibrary.org/obo/OAE_0000866","http://purl.obolibrary.org/obo/OAE_0000917","http://purl.obolibrary.org/obo/OAE_0000294","http://purl.obolibrary.org/obo/OAE_0000487","http://purl.obolibrary.org/obo/OAE_0001217","http://purl.obolibrary.org/obo/OAE_0000396","http://purl.obolibrary.org/obo/OAE_0000362","http://purl.obolibrary.org/obo/OAE_0000501","http://purl.obolibrary.org/obo/OAE_0000211","http://purl.obolibrary.org/obo/OAE_0001364"],"http://purl.obolibrary.org/obo#DBSalt":["demeclocycline hydrochloride","demeclocycline hcl","demethylchlortetracycline hydrochloride"],"http://purl.obolibrary.org/obo/dinto_000303":["http://purl.obolibrary.org/obo/dinto_2852","http://purl.obolibrary.org/obo/dinto_0908"],"http://purl.obolibrary.org/obo/dinto_000404":["http://purl.obolibrary.org/obo/dinto_2852","http://purl.obolibrary.org/obo/dinto_0908"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://purl.obolibrary.org/obo/dinto_000154":["http://purl.obolibrary.org/obo/CHEBI_36047"],"http://purl.obolibrary.org/obo#InChIKey":["InChIKey=FMTDIUIBLCQGJB-SEYHBJAFSA-N"],"http://purl.obolibrary.org/obo#AHFScode":["08:12.24"],"http://purl.obolibrary.org/obo#Synonym":["DMCT","demeclocycline","demeclocyclinum","7-chloro-6-demethyltetracycline","[4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide","C21H21ClN2O8","demeclociclina","Demeclocycline","DMCTC","(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide","demethylchlortetracycline","6-demethyl-7-chlorotetracycline"],"http://purl.obolibrary.org/obo#xref":["Wikipedia:Demeclocycline","CASRN:127-33-3","DrugBank:DB00618","Patent:US2878289","Wikipedia:http://en.wikipedia.org/wiki/Demeclocycline","Patent:FR1344645","ChEBI:4392","RxList:http://www.rxlist.com/cgi/generic3/demeclocycline.htm","Drugs.com:http://www.drugs.com/cdi/demeclocycline.html","KEGG DRUG:D03680","Patent:US3019172","Patent:US3154476","National Drug Code Directory:61748-115-01","Beilstein:2230579","Patent:US3012946","PharmGKB:PA164745513","Patent:US3050446","Drugs Product Database (DPD):2169924"],"http://purl.obolibrary.org/obo#CASRN":["127-33-3"],"https://data.bioontology.org/metadata/prefixIRI":["obo2:CHEBI_4392"],"http://purl.obolibrary.org/obo#SMILES":["[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)C1=C([C@H]2O)C(Cl)=CC=C1O","[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c1c(O)ccc(Cl)c1[C@H]2O"],"http://purl.obolibrary.org/obo/dinto_000499":["http://purl.obolibrary.org/obo/CHEBI_7809","http://purl.obolibrary.org/obo/CHEBI_5098","http://purl.obolibrary.org/obo/dinto_DB01604","http://purl.obolibrary.org/obo/dinto_DB00417","http://purl.obolibrary.org/obo/CHEBI_5683","http://purl.obolibrary.org/obo/CHEBI_2956","http://purl.obolibrary.org/obo/CHEBI_50859","http://purl.obolibrary.org/obo/CHEBI_4913","http://purl.obolibrary.org/obo/CHEBI_18208","http://purl.obolibrary.org/obo/dinto_DB00893","http://purl.obolibrary.org/obo/CHEBI_3393","http://purl.obolibrary.org/obo/CHEBI_161680","http://purl.obolibrary.org/obo/CHEBI_53766","http://purl.obolibrary.org/obo/dinto_DB00258","http://purl.obolibrary.org/obo/dinto_DB01370","http://purl.obolibrary.org/obo/CHEBI_50173","http://purl.obolibrary.org/obo/CHEBI_133809","http://purl.obolibrary.org/obo/CHEBI_28971","http://purl.obolibrary.org/obo/CHEBI_31794","http://purl.obolibrary.org/obo/dinto_DB01574","http://purl.obolibrary.org/obo/CHEBI_48947","http://purl.obolibrary.org/obo/dinto_DB01357","http://purl.obolibrary.org/obo/CHEBI_59594","http://purl.obolibrary.org/obo/dinto_DB01593","http://purl.obolibrary.org/obo/CHEBI_15367","http://purl.obolibrary.org/obo/CHEBI_6919","http://purl.obolibrary.org/obo/CHEBI_6827","http://purl.obolibrary.org/obo/dinto_DB01378","http://purl.obolibrary.org/obo/CHEBI_10033","http://purl.obolibrary.org/obo/CHEBI_9587","http://purl.obolibrary.org/obo/CHEBI_49566","http://purl.obolibrary.org/obo/dinto_DB01606","http://purl.obolibrary.org/obo/dinto_DB01164","http://purl.obolibrary.org/obo/CHEBI_7447","http://purl.obolibrary.org/obo/CHEBI_31444","http://purl.obolibrary.org/obo/dinto_DB00977","http://purl.obolibrary.org/obo/CHEBI_4513","http://purl.obolibrary.org/obo/CHEBI_4511","http://purl.obolibrary.org/obo/CHEBI_6067","http://purl.obolibrary.org/obo/dinto_DB01373","http://purl.obolibrary.org/obo/dinto_DB01028","http://purl.obolibrary.org/obo/dinto_DB01592","http://purl.obolibrary.org/obo/CHEBI_8232","http://purl.obolibrary.org/obo/CHEBI_2968","http://purl.obolibrary.org/obo/CHEBI_51210","http://purl.obolibrary.org/obo/CHEBI_2676"],"http://www.w3.org/2000/01/rdf-schema#label":["demeclocycline"],"http://purl.obolibrary.org/obo#DBname":["demeclocycline"],"http://purl.obolibrary.org/obo#InChI":["InChI=1S/C21H21ClN2O8/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31)/t6-,7-,14-,15-,21-/m0/s1"],"http://purl.obolibrary.org/obo#DBBrand":["diuciclin","mexocine","demeclor","elkamicina","bioterciclin","clortetrin","novotriclina","sumaclina","ledermycin","perciclina","deganol","declomycin","demetraclin"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"]},"@id":"http://purl.obolibrary.org/obo/CHEBI_4392","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_4392","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007fbd5ffec6e8 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-0083660248b7/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}