{"id":"http://purl.obolibrary.org/obo/CHEBI_6438","prefLabel":"levobunolol","synonym":["levobunololum","5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2H)-one","C17H25NO3","5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalen-1-one","Levobunolol","(S)-5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone"],"prefixIRI":"obo2:CHEBI_6438","label":["levobunolol"],"subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"],"parents":[{"id":"http://purl.obolibrary.org/obo/dinto_000055","prefLabel":"pharmacological entity","prefixIRI":"obo2:dinto_000055","label":["pharmacological entity"],"definition":["This class imports chemical entities from the ChEBI ontology that have a relationship 'has role' with the class 'drug' in this ontology and other chemical entities included in the pharmacological database DrugBank (but not in ChEBI).\nTherefore all subclasses of the class 'pharmacological entity' share they capacity to produce some pharmacological activity within a biological system."],"subClassOf":["http://purl.obolibrary.org/obo/CHEBI_24431"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/dinto_000055","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"definition":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://purl.obolibrary.org/obo#DBSynonym":["levobunolol hcl","levobunololum [inn-latin]"],"http://purl.obolibrary.org/obo#ATCCode":["S01ED03"],"https://data.bioontology.org/metadata/def/prefLabel":["levobunolol"],"http://purl.obolibrary.org#Definition":["A cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma."],"http://purl.obolibrary.org/obo/dinto_000159":["http://purl.obolibrary.org/obo/OAE_0000388","http://purl.obolibrary.org/obo/OAE_0000377","http://purl.obolibrary.org/obo/OAE_0000218","http://purl.obolibrary.org/obo/OAE_0000376","http://purl.obolibrary.org/obo/OAE_0000335","http://purl.obolibrary.org/obo/OAE_0000198","http://purl.obolibrary.org/obo/OAE_0000406","http://purl.obolibrary.org/obo/OAE_0000921","http://purl.obolibrary.org/obo/OAE_0000415","http://purl.obolibrary.org/obo/OAE_0000373","http://purl.obolibrary.org/obo/OAE_0000660","http://purl.obolibrary.org/obo/OAE_0001370","http://purl.obolibrary.org/obo/OAE_0000382","http://purl.obolibrary.org/obo/OAE_0000600","http://purl.obolibrary.org/obo/OAE_0000310","http://purl.obolibrary.org/obo/OAE_0000770","http://purl.obolibrary.org/obo/OAE_0001357","http://purl.obolibrary.org/obo/OAE_0000551","http://purl.obolibrary.org/obo/OAE_0000802","http://purl.obolibrary.org/obo/OAE_0001057","http://purl.obolibrary.org/obo/OAE_0000400","http://purl.obolibrary.org/obo/OAE_0000584","http://purl.obolibrary.org/obo/OAE_0000542","http://purl.obolibrary.org/obo/OAE_0000780","http://purl.obolibrary.org/obo/OAE_0000405","http://purl.obolibrary.org/obo/OAE_0000779","http://purl.obolibrary.org/obo/OAE_0000362","http://purl.obolibrary.org/obo/OAE_0000374","http://purl.obolibrary.org/obo/OAE_0000534"],"http://purl.obolibrary.org/obo/dinto_000303":["http://purl.obolibrary.org/obo/dinto_2907","http://purl.obolibrary.org/obo/dinto_3504"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://purl.obolibrary.org/obo/dinto_000154":["http://purl.obolibrary.org/obo/CHEBI_39456","http://purl.obolibrary.org/obo/CHEBI_35530"],"http://purl.obolibrary.org/obo#InChIKey":["InChIKey=IXHBTMCLRNMKHZ-LBPRGKRZSA-N"],"http://purl.obolibrary.org/obo/dinto_000429":["http://purl.obolibrary.org/obo/dinto_2907","http://purl.obolibrary.org/obo/dinto_3504"],"http://purl.obolibrary.org/obo#AHFScode":["52:92.00"],"http://purl.obolibrary.org/obo#Synonym":["levobunololum","5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2H)-one","C17H25NO3","5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalen-1-one","Levobunolol","(S)-5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone"],"http://purl.obolibrary.org/obo#xref":["Wikipedia:http://en.wikipedia.org/wiki/Levobunolol","Drugs.com:http://www.drugs.com/cdi/levobunolol-drops.html","CiteXplore:3067745","CiteXplore:19626454","KEGG COMPOUND:C07914","Drugs Product Database (DPD):2241575","Wikipedia:Levobunolol","CASRN:47141-42-4","Patent:WO2011140194","CiteXplore:2881799","CiteXplore:23390358","Patent:US2011275617","CiteXplore:3019819","National Drug Code Directory:0023-4526-10","Beilstein:6484587","DrugBank:DB01210","CiteXplore:21368570","CiteXplore:3050679","KEGG DRUG:D08115","Patent:WO2008002929","CiteXplore:3513594","CiteXplore:3058836","Reaxys:6484587","PubChem Compound:39468","CiteXplore:3062528","PubChem Substance:46507518","CiteXplore:20960417","ChemSpider:36089","PharmGKB:PA164747027","ChEBI:6438","ChEMBL:775188","RxList:http://www.rxlist.com/cgi/generic/levobunolol.htm","CiteXplore:3912600","Patent:US2011263638","CiteXplore:3881032","CiteXplore:2873545","HMDB:HMDB15341"],"http://purl.obolibrary.org/obo#CASRN":["47141-42-4"],"https://data.bioontology.org/metadata/prefixIRI":["obo2:CHEBI_6438"],"http://purl.obolibrary.org/obo#SMILES":["CC(C)(C)NC[C@H](O)COC1=CC=CC2=C1CCCC2=O","CC(C)(C)NC[C@H](O)COc1cccc2C(=O)CCCc12"],"http://purl.obolibrary.org/obo/dinto_000499":["http://purl.obolibrary.org/obo/CHEBI_50861"],"http://www.w3.org/2000/01/rdf-schema#label":["levobunolol"],"http://purl.obolibrary.org/obo#DBname":["levobunolol"],"http://purl.obolibrary.org/obo#InChI":["InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1"],"http://purl.obolibrary.org/obo#DBBrand":["akbeta","betagan"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"]},"@id":"http://purl.obolibrary.org/obo/CHEBI_6438","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FCHEBI_6438","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007fbd5ffec6e8 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-0083660248b7/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}