{"id":"http://purl.obolibrary.org/obo/dinto_1979","prefLabel":"solute carrier family 22 member 2","synonym":["organic cation transporter 2","hoct2"],"prefixIRI":"obo2:dinto_1979","label":["solute carrier family 22 member 2"],"subClassOf":["http://purl.obolibrary.org/obo/dinto_000133"],"parents":[{"id":"http://purl.obolibrary.org/obo/dinto_000133","prefLabel":"transporter","prefixIRI":"obo2:dinto_000133","label":["transporter"],"subClassOf":["http://purl.obolibrary.org/obo/dinto_000129"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"definition":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/dinto_000133","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000133","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"definition":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"https://data.bioontology.org/metadata/def/prefLabel":["solute carrier family 22 member 2"],"http://purl.obolibrary.org#Definition":["Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://purl.obolibrary.org/obo/dinto_000427":["http://purl.obolibrary.org/obo/CHEBI_28487","http://purl.obolibrary.org/obo/CHEBI_28918","http://purl.obolibrary.org/obo/dinto_DB00122","http://purl.obolibrary.org/obo/dinto_DB08838","http://purl.obolibrary.org/obo/CHEBI_8356","http://purl.obolibrary.org/obo/CHEBI_51193","http://purl.obolibrary.org/obo/CHEBI_3699","http://purl.obolibrary.org/obo/CHEBI_28680","http://purl.obolibrary.org/obo/dinto_DB00570","http://purl.obolibrary.org/obo/CHEBI_18243","http://purl.obolibrary.org/obo/CHEBI_31941","http://purl.obolibrary.org/obo/CHEBI_63577","http://purl.obolibrary.org/obo/CHEBI_567361","http://purl.obolibrary.org/obo/CHEBI_6801","http://purl.obolibrary.org/obo/CHEBI_64312","http://purl.obolibrary.org/obo/dinto_DB00694","http://purl.obolibrary.org/obo/CHEBI_18357","http://purl.obolibrary.org/obo/CHEBI_27899","http://purl.obolibrary.org/obo/CHEBI_64323","http://purl.obolibrary.org/obo/CHEBI_8364"],"http://purl.obolibrary.org/obo/dinto_000405":["http://purl.obolibrary.org/obo/CHEBI_4975","http://purl.obolibrary.org/obo/CHEBI_28918","http://purl.obolibrary.org/obo/CHEBI_4636","http://purl.obolibrary.org/obo/dinto_DB00122","http://purl.obolibrary.org/obo/CHEBI_8499","http://purl.obolibrary.org/obo/CHEBI_47499","http://purl.obolibrary.org/obo/CHEBI_8711","http://purl.obolibrary.org/obo/CHEBI_51193","http://purl.obolibrary.org/obo/CHEBI_8064","http://purl.obolibrary.org/obo/CHEBI_3699","http://purl.obolibrary.org/obo/CHEBI_18723","http://purl.obolibrary.org/obo/CHEBI_15551","http://purl.obolibrary.org/obo/CHEBI_18243","http://purl.obolibrary.org/obo/dinto_DB02533","http://purl.obolibrary.org/obo/CHEBI_63598","http://purl.obolibrary.org/obo/dinto_DB00365","http://purl.obolibrary.org/obo/CHEBI_2618","http://purl.obolibrary.org/obo/CHEBI_6904","http://purl.obolibrary.org/obo/CHEBI_6801","http://purl.obolibrary.org/obo/dinto_DB00783","http://purl.obolibrary.org/obo/dinto_DB00925","http://purl.obolibrary.org/obo/dinto_DB00536","http://purl.obolibrary.org/obo/dinto_DB01580","http://purl.obolibrary.org/obo/CHEBI_28593","http://purl.obolibrary.org/obo/dinto_DB00345","http://purl.obolibrary.org/obo/dinto_DB00152","http://purl.obolibrary.org/obo/CHEBI_17026","http://purl.obolibrary.org/obo/CHEBI_27958","http://purl.obolibrary.org/obo/CHEBI_18357","http://purl.obolibrary.org/obo/dinto_DB00690","http://purl.obolibrary.org/obo/CHEBI_2639","http://purl.obolibrary.org/obo/CHEBI_27899","http://purl.obolibrary.org/obo/CHEBI_4657","http://purl.obolibrary.org/obo/CHEBI_15854","http://purl.obolibrary.org/obo/CHEBI_8426","http://purl.obolibrary.org/obo/CHEBI_8428","http://purl.obolibrary.org/obo/dinto_DB01114","http://purl.obolibrary.org/obo/CHEBI_8364","http://purl.obolibrary.org/obo/CHEBI_47781","http://purl.obolibrary.org/obo/CHEBI_45783"],"http://purl.obolibrary.org/obo#Synonym":["organic cation transporter 2","hoct2"],"http://purl.obolibrary.org/obo#OrganismClass":["human"],"http://purl.obolibrary.org/obo#xref":["UniProt ID:O15244","DrugBank:6144"],"http://purl.obolibrary.org/obo/IAO_0000119":["DrugBank Database"],"https://data.bioontology.org/metadata/prefixIRI":["obo2:dinto_1979"],"http://purl.obolibrary.org/obo/dinto_000408":["http://purl.obolibrary.org/obo/dinto_DB01160","http://purl.obolibrary.org/obo/CHEBI_10110","http://purl.obolibrary.org/obo/CHEBI_7907","http://purl.obolibrary.org/obo/dinto_DB08837","http://purl.obolibrary.org/obo/CHEBI_9774"],"http://www.w3.org/2000/01/rdf-schema#label":["solute carrier family 22 member 2"],"http://purl.obolibrary.org/obo#Gene":["slc22a2"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/dinto_000133"]},"@id":"http://purl.obolibrary.org/obo/dinto_1979","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_1979","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}