{"id":"http://purl.obolibrary.org/obo/dinto_DB00047","prefLabel":"insulin glargine","prefixIRI":"obo2:dinto_DB00047","label":["insulin glargine"],"subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"],"parents":[{"id":"http://purl.obolibrary.org/obo/dinto_000055","prefLabel":"pharmacological entity","prefixIRI":"obo2:dinto_000055","label":["pharmacological entity"],"definition":["This class imports chemical entities from the ChEBI ontology that have a relationship 'has role' with the class 'drug' in this ontology and other chemical entities included in the pharmacological database DrugBank (but not in ChEBI).\nTherefore all subclasses of the class 'pharmacological entity' share they capacity to produce some pharmacological activity within a biological system."],"subClassOf":["http://purl.obolibrary.org/obo/CHEBI_24431"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/dinto_000055","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"synonym":[],"definition":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://purl.obolibrary.org/obo#DBSynonym":["insulin glargine (rdna origin)"],"http://purl.obolibrary.org/obo#ATCCode":["A10AE04"],"https://data.bioontology.org/metadata/def/prefLabel":["insulin glargine"],"http://purl.obolibrary.org#Definition":["Insulin glargine is produced by recombinant DNA technology using a non-pathogenic laboratory strain of Escherichia coli (K12) as the production organism. It is an analogue of human insulin made by replacing the asparagine residue at position A21 of the A-chain with glycine and adding two arginines to the C-terminus (positions B31 and 32) of the B-chain. The resulting protein is soluble at pH 4 and forms microprecipitates at physiological pH 7.4. Small amounts of insulin glargine are slowly released from microprecipitates giving the drug a long duration of action (up to 24 hours) and no pronounced peak concentration."],"http://purl.obolibrary.org/obo/dinto_000159":["http://purl.obolibrary.org/obo/OAE_0000879","http://purl.obolibrary.org/obo/OAE_0001373","http://purl.obolibrary.org/obo/OAE_0000557","http://purl.obolibrary.org/obo/OAE_0000377","http://purl.obolibrary.org/obo/OAE_0000376","http://purl.obolibrary.org/obo/OAE_0000567","http://purl.obolibrary.org/obo/OAE_0000373","http://purl.obolibrary.org/obo/OAE_0000418","http://purl.obolibrary.org/obo/OAE_0000319","http://purl.obolibrary.org/obo/OAE_0000403","http://purl.obolibrary.org/obo/OAE_0000770","http://purl.obolibrary.org/obo/OAE_0000632","http://purl.obolibrary.org/obo/OAE_0000551","http://purl.obolibrary.org/obo/OAE_0000498","http://purl.obolibrary.org/obo/OAE_0001057","http://purl.obolibrary.org/obo/OAE_0001515","http://purl.obolibrary.org/obo/OAE_0000584","http://purl.obolibrary.org/obo/OAE_0000414","http://purl.obolibrary.org/obo/OAE_0000789","http://purl.obolibrary.org/obo/OAE_0000343","http://purl.obolibrary.org/obo/OAE_0000022","http://purl.obolibrary.org/obo/OAE_0000385","http://purl.obolibrary.org/obo/OAE_0000491","http://purl.obolibrary.org/obo/OAE_0000362","http://purl.obolibrary.org/obo/OAE_0000374","http://purl.obolibrary.org/obo/OAE_0000462","http://purl.obolibrary.org/obo/OAE_0000358","http://purl.obolibrary.org/obo/OAE_0000350"],"http://purl.obolibrary.org/obo/dinto_000303":["http://purl.obolibrary.org/obo/dinto_0892"],"http://purl.obolibrary.org/obo/dinto_000406":["http://purl.obolibrary.org/obo/dinto_2651"],"http://purl.obolibrary.org/obo/dinto_000430":["http://purl.obolibrary.org/obo/dinto_0892","http://purl.obolibrary.org/obo/dinto_2264"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://purl.obolibrary.org/obo#AHFScode":["68:20.08"],"http://purl.obolibrary.org/obo#xref":["Drugs Product Database (DPD):2245689","Drugs.com:http://www.drugs.com/cdi/insulin-glargine-cartridge-systems.html","Wikipedia:http://en.wikipedia.org/wiki/Insulin_glargine","National Drug Code Directory:0088-2220-60","RxList:http://www.rxlist.com/cgi/generic2/lantus.htm","PharmGKB:PA449992"],"http://purl.obolibrary.org/obo#CASRN":["160337-95-1"],"https://data.bioontology.org/metadata/prefixIRI":["obo2:dinto_DB00047"],"http://purl.obolibrary.org/obo/dinto_000499":["http://purl.obolibrary.org/obo/CHEBI_8214","http://purl.obolibrary.org/obo/CHEBI_3437","http://purl.obolibrary.org/obo/CHEBI_8499","http://purl.obolibrary.org/obo/CHEBI_4856","http://purl.obolibrary.org/obo/CHEBI_63622","http://purl.obolibrary.org/obo/CHEBI_3127","http://purl.obolibrary.org/obo/dinto_DB00373","http://purl.obolibrary.org/obo/CHEBI_238698","http://purl.obolibrary.org/obo/CHEBI_3441","http://purl.obolibrary.org/obo/CHEBI_2904","http://purl.obolibrary.org/obo/dinto_DB01359","http://purl.obolibrary.org/obo/CHEBI_6904","http://purl.obolibrary.org/obo/dinto_DB00052","http://purl.obolibrary.org/obo/CHEBI_2379","http://purl.obolibrary.org/obo/CHEBI_3082","http://purl.obolibrary.org/obo/dinto_DB01580","http://purl.obolibrary.org/obo/CHEBI_7444","http://purl.obolibrary.org/obo/CHEBI_6343","http://purl.obolibrary.org/obo/CHEBI_258351"],"http://www.w3.org/2000/01/rdf-schema#label":["insulin glargine"],"http://purl.obolibrary.org/obo#DBBrand":["lantus","lantus optiset","lantus solostar"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"]},"@id":"http://purl.obolibrary.org/obo/dinto_DB00047","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00047","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007fbd5ffec6e8 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-0083660248b7/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}