{"id":"http://purl.obolibrary.org/obo/dinto_DB00072","prefLabel":"trastuzumab","prefixIRI":"obo2:dinto_DB00072","label":["trastuzumab"],"subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"],"parents":[{"id":"http://purl.obolibrary.org/obo/dinto_000055","prefLabel":"pharmacological entity","prefixIRI":"obo2:dinto_000055","label":["pharmacological entity"],"definition":["This class imports chemical entities from the ChEBI ontology that have a relationship 'has role' with the class 'drug' in this ontology and other chemical entities included in the pharmacological database DrugBank (but not in ChEBI).\nTherefore all subclasses of the class 'pharmacological entity' share they capacity to produce some pharmacological activity within a biological system."],"subClassOf":["http://purl.obolibrary.org/obo/CHEBI_24431"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/dinto_000055","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"synonym":[],"definition":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://purl.obolibrary.org/obo#DBSynonym":["ig gamma-1 chain c region","anti her2"],"http://purl.obolibrary.org/obo#ATCCode":["L01XC03"],"https://data.bioontology.org/metadata/def/prefLabel":["trastuzumab"],"http://purl.obolibrary.org#Definition":["A recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein. Produced in CHO cell culture.*"],"http://purl.obolibrary.org/obo/dinto_000303":["http://purl.obolibrary.org/obo/dinto_0259"],"http://purl.obolibrary.org/obo/dinto_000404":["http://purl.obolibrary.org/obo/dinto_3102"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://purl.obolibrary.org/obo#xref":["GenBank:J00228","RxList:http://www.rxlist.com/cgi/generic/trastuz.htm","National Drug Code Directory:50242-134-68","Drugs Product Database (DPD):2240692","PharmGKB:PA451743","Wikipedia:http://en.wikipedia.org/wiki/Trastuzumab","UniProtKB:P01857","Drugs.com:http://www.drugs.com/cdi/trastuzumab.html"],"http://purl.obolibrary.org/obo#CASRN":["180288-69-1"],"https://data.bioontology.org/metadata/prefixIRI":["obo2:dinto_DB00072"],"http://purl.obolibrary.org/obo/dinto_000408":["http://purl.obolibrary.org/obo/dinto_3109","http://purl.obolibrary.org/obo/dinto_3105","http://purl.obolibrary.org/obo/dinto_3106","http://purl.obolibrary.org/obo/dinto_3107","http://purl.obolibrary.org/obo/dinto_3078","http://purl.obolibrary.org/obo/dinto_3084","http://purl.obolibrary.org/obo/dinto_2792","http://purl.obolibrary.org/obo/dinto_3112","http://purl.obolibrary.org/obo/dinto_3111","http://purl.obolibrary.org/obo/dinto_0259","http://purl.obolibrary.org/obo/dinto_3709","http://purl.obolibrary.org/obo/dinto_3461","http://purl.obolibrary.org/obo/dinto_3466"],"http://purl.obolibrary.org/obo/dinto_000499":["http://purl.obolibrary.org/obo/dinto_DB00276","http://purl.obolibrary.org/obo/CHEBI_31348","http://purl.obolibrary.org/obo/CHEBI_5864","http://purl.obolibrary.org/obo/CHEBI_41879","http://purl.obolibrary.org/obo/CHEBI_71417","http://purl.obolibrary.org/obo/CHEBI_2948","http://purl.obolibrary.org/obo/dinto_DB00385","http://purl.obolibrary.org/obo/CHEBI_45863","http://purl.obolibrary.org/obo/CHEBI_49668","http://purl.obolibrary.org/obo/dinto_DB00541","http://purl.obolibrary.org/obo/CHEBI_4672","http://purl.obolibrary.org/obo/CHEBI_28901","http://purl.obolibrary.org/obo/CHEBI_4305","http://purl.obolibrary.org/obo/dinto_DB00108","http://purl.obolibrary.org/obo/dinto_DB00552","http://purl.obolibrary.org/obo/CHEBI_44185","http://purl.obolibrary.org/obo/dinto_DB00928","http://purl.obolibrary.org/obo/CHEBI_681569","http://purl.obolibrary.org/obo/CHEBI_4027","http://purl.obolibrary.org/obo/dinto_DB00970","http://purl.obolibrary.org/obo/dinto_DB00005","http://purl.obolibrary.org/obo/CHEBI_4911","http://purl.obolibrary.org/obo/dinto_DB01206","http://purl.obolibrary.org/obo/dinto_DB00997","http://purl.obolibrary.org/obo/dinto_DB00054","http://purl.obolibrary.org/obo/CHEBI_4031","http://purl.obolibrary.org/obo/CHEBI_63612","http://purl.obolibrary.org/obo/CHEBI_61049","http://purl.obolibrary.org/obo/dinto_DB01380","http://purl.obolibrary.org/obo/dinto_DB00291","http://purl.obolibrary.org/obo/CHEBI_9513","http://purl.obolibrary.org/obo/CHEBI_3077","http://purl.obolibrary.org/obo/dinto_DB06287","http://purl.obolibrary.org/obo/CHEBI_63632","http://purl.obolibrary.org/obo/dinto_DB00081","http://purl.obolibrary.org/obo/CHEBI_8382","http://purl.obolibrary.org/obo/CHEBI_44423","http://purl.obolibrary.org/obo/CHEBI_17650","http://purl.obolibrary.org/obo/CHEBI_28680","http://purl.obolibrary.org/obo/dinto_DB01285","http://purl.obolibrary.org/obo/dinto_DB00570","http://purl.obolibrary.org/obo/CHEBI_31941","http://purl.obolibrary.org/obo/dinto_DB04572","http://purl.obolibrary.org/obo/CHEBI_63599","http://purl.obolibrary.org/obo/dinto_DB00290","http://purl.obolibrary.org/obo/CHEBI_9288","http://purl.obolibrary.org/obo/CHEBI_8764","http://purl.obolibrary.org/obo/dinto_DB01177","http://purl.obolibrary.org/obo/CHEBI_15367","http://purl.obolibrary.org/obo/dinto_DB00078","http://purl.obolibrary.org/obo/CHEBI_567361","http://purl.obolibrary.org/obo/CHEBI_75988","http://purl.obolibrary.org/obo/CHEBI_52172","http://purl.obolibrary.org/obo/dinto_DB00095","http://purl.obolibrary.org/obo/CHEBI_60761","http://purl.obolibrary.org/obo/dinto_DB00888","http://purl.obolibrary.org/obo/CHEBI_175901","http://purl.obolibrary.org/obo/dinto_DB00065","http://purl.obolibrary.org/obo/CHEBI_3423","http://purl.obolibrary.org/obo/dinto_DB00051","http://purl.obolibrary.org/obo/dinto_DB00004","http://purl.obolibrary.org/obo/CHEBI_50885","http://purl.obolibrary.org/obo/dinto_DB06372","http://purl.obolibrary.org/obo/CHEBI_480999","http://purl.obolibrary.org/obo/CHEBI_50924","http://purl.obolibrary.org/obo/CHEBI_6888","http://purl.obolibrary.org/obo/CHEBI_50729","http://purl.obolibrary.org/obo/dinto_DB00111","http://purl.obolibrary.org/obo/CHEBI_63791","http://purl.obolibrary.org/obo/dinto_DB00073","http://purl.obolibrary.org/obo/dinto_DB00026","http://purl.obolibrary.org/obo/CHEBI_47898","http://purl.obolibrary.org/obo/CHEBI_72564","http://purl.obolibrary.org/obo/CHEBI_9168","http://purl.obolibrary.org/obo/dinto_DB00023","http://purl.obolibrary.org/obo/dinto_DB00762","http://purl.obolibrary.org/obo/dinto_DB00488","http://purl.obolibrary.org/obo/dinto_DB00694","http://purl.obolibrary.org/obo/dinto_DB01281","http://purl.obolibrary.org/obo/CHEBI_50667","http://purl.obolibrary.org/obo/CHEBI_4868","http://purl.obolibrary.org/obo/CHEBI_8378","http://purl.obolibrary.org/obo/CHEBI_27899","http://purl.obolibrary.org/obo/dinto_DB00059","http://purl.obolibrary.org/obo/CHEBI_28876","http://purl.obolibrary.org/obo/dinto_DB00305","http://purl.obolibrary.org/obo/CHEBI_71418","http://purl.obolibrary.org/obo/CHEBI_114785","http://purl.obolibrary.org/obo/CHEBI_9555","http://purl.obolibrary.org/obo/CHEBI_46345","http://purl.obolibrary.org/obo/CHEBI_31355","http://purl.obolibrary.org/obo/dinto_DB00075","http://purl.obolibrary.org/obo/dinto_DB00074","http://purl.obolibrary.org/obo/CHEBI_38940","http://purl.obolibrary.org/obo/CHEBI_45783","http://purl.obolibrary.org/obo/CHEBI_168396","http://purl.obolibrary.org/obo/dinto_DB00087"],"http://www.w3.org/2000/01/rdf-schema#label":["trastuzumab"],"http://purl.obolibrary.org/obo#DBBrand":["herceptin"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"]},"@id":"http://purl.obolibrary.org/obo/dinto_DB00072","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00072","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007f453dc33af0 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-0083660248b7/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}