{"id":"http://purl.obolibrary.org/obo/dinto_DB00648","prefLabel":"mitotane","synonym":["1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene","C14H10Cl4"],"prefixIRI":"obo2:dinto_DB00648","label":["mitotane"],"subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"],"parents":[{"id":"http://purl.obolibrary.org/obo/dinto_000055","prefLabel":"pharmacological entity","prefixIRI":"obo2:dinto_000055","label":["pharmacological entity"],"definition":["This class imports chemical entities from the ChEBI ontology that have a relationship 'has role' with the class 'drug' in this ontology and other chemical entities included in the pharmacological database DrugBank (but not in ChEBI).\nTherefore all subclasses of the class 'pharmacological entity' share they capacity to produce some pharmacological activity within a biological system."],"subClassOf":["http://purl.obolibrary.org/obo/CHEBI_24431"],"prefLabelXl":[],"altLabelXl":[],"hiddenLabelXl":[],"synonym":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"@id":"http://purl.obolibrary.org/obo/dinto_000055","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_000055","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}],"definition":[],"obsolete":false,"notation":null,"semanticType":[],"cui":[],"xref":null,"inScheme":[],"created":null,"modified":null,"memberOf":[],"altLabelXl":[],"hiddenLabelXl":[],"prefLabelXl":[],"isInActiveScheme":[null],"isInActiveCollection":[],"properties":{"http://purl.obolibrary.org/obo#ATCCode":["L01XX23"],"https://data.bioontology.org/metadata/def/prefLabel":["mitotane"],"http://purl.obolibrary.org#Definition":["A derivative of the insecticide  dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. [PubChem]"],"http://purl.obolibrary.org/obo/dinto_000159":["http://purl.obolibrary.org/obo/OAE_0000388","http://purl.obolibrary.org/obo/OAE_0000391","http://purl.obolibrary.org/obo/OAE_0001509","http://purl.obolibrary.org/obo/OAE_0000021","http://purl.obolibrary.org/obo/OAE_0000600","http://purl.obolibrary.org/obo/OAE_0000403","http://purl.obolibrary.org/obo/OAE_0000601","http://purl.obolibrary.org/obo/OAE_0000642","http://purl.obolibrary.org/obo/OAE_0000551","http://purl.obolibrary.org/obo/OAE_0000460","http://purl.obolibrary.org/obo/OAE_0000396","http://purl.obolibrary.org/obo/OAE_0000362"],"http://purl.obolibrary.org/obo/dinto_000303":["http://purl.obolibrary.org/obo/dinto_2667"],"http://purl.obolibrary.org/obo/dinto_000406":["http://purl.obolibrary.org/obo/dinto_2667"],"http://www.w3.org/1999/02/22-rdf-syntax-ns#type":["http://www.w3.org/2002/07/owl#Class"],"http://purl.obolibrary.org/obo#InChIKey":["InChIKey=JWBOIMRXGHLCPP-UHFFFAOYSA-N"],"http://purl.obolibrary.org/obo#AHFScode":["10:00.00"],"http://purl.obolibrary.org/obo#Synonym":["1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene","C14H10Cl4"],"http://purl.obolibrary.org/obo#xref":["PubChem Substance:46508319","National Drug Code Directory:0015-3080-60","ChemSpider:4066","Drugs.com:http://www.drugs.com/cdi/mitotane.html","Wikipedia:http://en.wikipedia.org/wiki/Mitotane","Drugs Product Database (DPD):463221","RxList:http://www.rxlist.com/cgi/generic2/mitotane.htm","PubChem Compound:4211","PharmGKB:PA164746157"],"http://purl.obolibrary.org/obo#CASRN":["53-19-0"],"https://data.bioontology.org/metadata/prefixIRI":["obo2:dinto_DB00648"],"http://purl.obolibrary.org/obo/dinto_000408":["http://purl.obolibrary.org/obo/dinto_2146","http://purl.obolibrary.org/obo/dinto_3535","http://purl.obolibrary.org/obo/dinto_2163"],"http://purl.obolibrary.org/obo#SMILES":["ClC(Cl)C(C1=CC=C(Cl)C=C1)C1=CC=CC=C1Cl"],"http://purl.obolibrary.org/obo/dinto_000499":["http://purl.obolibrary.org/obo/CHEBI_53766","http://purl.obolibrary.org/obo/CHEBI_133809","http://purl.obolibrary.org/obo/CHEBI_9241","http://purl.obolibrary.org/obo/CHEBI_10033","http://purl.obolibrary.org/obo/CHEBI_4513"],"http://www.w3.org/2000/01/rdf-schema#label":["mitotane"],"http://purl.obolibrary.org/obo#InChI":["InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H"],"http://purl.obolibrary.org/obo#DBBrand":["mitotanum [inn-latin]","chlodithan","lysodren","chlodithane","mitotan","chloditan","khlodithan"],"http://www.w3.org/2000/01/rdf-schema#subClassOf":["http://purl.obolibrary.org/obo/dinto_000055"]},"@id":"http://purl.obolibrary.org/obo/dinto_DB00648","@type":"http://www.w3.org/2002/07/owl#Class","links":{"self":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648","ontology":"https://data.bioontology.org/ontologies/DINTO","children":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648/children","parents":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648/parents","descendants":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648/descendants","ancestors":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648/ancestors","instances":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648/instances","tree":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648/tree","notes":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648/notes","mappings":"https://data.bioontology.org/ontologies/DINTO/classes/http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648/mappings","ui":"http://bioportal.bioontology.org/ontologies/DINTO?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2Fdinto_DB00648","@context":{"self":"http://www.w3.org/2002/07/owl#Class","ontology":"http://data.bioontology.org/metadata/Ontology","children":"http://www.w3.org/2002/07/owl#Class","parents":"http://www.w3.org/2002/07/owl#Class","descendants":"http://www.w3.org/2002/07/owl#Class","ancestors":"http://www.w3.org/2002/07/owl#Class","instances":"http://data.bioontology.org/metadata/Instance","tree":"http://www.w3.org/2002/07/owl#Class","notes":"http://data.bioontology.org/metadata/Note","mappings":"http://data.bioontology.org/metadata/Mapping","ui":"http://www.w3.org/2002/07/owl#Class"}},"@context":{"@vocab":"http://data.bioontology.org/metadata/","label":"http://www.w3.org/2000/01/rdf-schema#label","prefLabel":"http://www.w3.org/2004/02/skos/core#prefLabel","prefLabelXl":"http://www.w3.org/2008/05/skos-xl#prefLabel","altLabelXl":"http://www.w3.org/2008/05/skos-xl#altLabel","hiddenLabelXl":"http://www.w3.org/2008/05/skos-xl#hiddenLabel","synonym":"http://www.w3.org/2004/02/skos/core#altLabel","definition":"http://www.w3.org/2004/02/skos/core#definition","obsolete":"http://www.w3.org/2002/07/owl#deprecated","notation":"http://www.w3.org/2004/02/skos/core#notation","prefixIRI":"http://data.bioontology.org/metadata/prefixIRI","parents":"http://www.w3.org/2000/01/rdf-schema##<Proc:0x00007fbd5ffec6e8 /opt/ontoportal/ontologies_api/shared/bundle/ruby/3.2.0/bundler/gems/ontologies_linked_data-0083660248b7/lib/ontologies_linked_data/models/class.rb:67 (lambda)>","subClassOf":"http://www.w3.org/2000/01/rdf-schema#subClassOf","semanticType":"http://bioportal.bioontology.org/ontologies/umls/hasSTY","cui":"http://bioportal.bioontology.org/ontologies/umls/cui","xref":"http://www.geneontology.org/formats/oboInOwl#hasDbXref","inScheme":"http://www.w3.org/2004/02/skos/core#inScheme","created":"http://purl.org/dc/terms/created","modified":"http://purl.org/dc/terms/modified","@language":[]}}